FlyBase Gene Report: Dmel\Prp19

General Information

Symbol

Dmel\Prp19

Species

D. melanogaster

Name

Pre-RNA processing factor 19

Annotation Symbol

CG5519

Feature Type

protein_coding_gene

FlyBase ID

FBgn0261119

Gene Model Status

Current

Stock Availability

6 publicly available

Gene Summary

Pre-RNA processing factor 19 (Prp19) encodes a protein involved in chromatin organization and alternative mRNA splicing regulation. [Date last reviewed: 2019-07-11] (FlyBase Gene Snapshot)

All Summaries

Gene Snapshot
Alliance
Auto summary
Gene Group
Interactive Fly

Also Known As

l(2)07838, Gbp

Key Links

Genomic Location

Cytogenetic map

55D1-55C9

Sequence location

2R:18,447,361..18,451,041 [-]

Recombination map

2-85

RefSeq locus

NT_033778 REGION:18447361..18451041

Sequence

Get Decorated FASTA

Genomic Maps

JBrowse GBrowse

Help me choose

Other Genome Views

The following external sites may use different assemblies or annotations than FlyBase.

Function

GO Summary Ribbons

Gene Ontology (GO) Annotations (13 terms)

Molecular Function (2 terms)

Terms Based on Experimental Evidence (0 terms)

Terms Based on Predictions or Assertions (2 terms)

CV Term

Evidence

References

enables ubiquitin protein ligase activity

inferred from electronic annotation with InterPro:IPR038959

(assigned by InterPro )

(FlyBase Curators et al., 2004-)

enables ubiquitin-protein transferase activity

inferred from biological aspect of ancestor with PANTHER:PTN000356711

(assigned by GO_Central )

(Gaudet et al., 2011)

inferred from sequence or structural similarity with HGNC:17896

(FlyBase Curators, 2008--)

Biological Process (6 terms)

Terms Based on Experimental Evidence (2 terms)

CV Term

Evidence

References

involved_in chromatin organization

inferred from mutant phenotype

(Klusza et al., 2013)

involved_in regulation of alternative mRNA splicing, via spliceosome

inferred from mutant phenotype

(Ashton-Beaucage et al., 2014)

Terms Based on Predictions or Assertions (4 terms)

CV Term

Evidence

References

involved_in DNA repair

inferred from electronic annotation with InterPro:IPR038959

(assigned by InterPro )

(FlyBase Curators et al., 2004-)

involved_in generation of catalytic spliceosome for first transesterification step

inferred from biological aspect of ancestor with PANTHER:PTN000356711

(assigned by GO_Central )

(Gaudet et al., 2011)

involved_in mRNA splicing, via spliceosome

inferred by curator from GO:0071011,GO:0071013

(Herold et al., 2009)

traceable author statement

(Milchanowski et al., 2004)

involved_in protein ubiquitination

inferred from sequence or structural similarity with HGNC:17896

(FlyBase Curators, 2008--)

Cellular Component (5 terms)

Terms Based on Experimental Evidence (2 terms)

CV Term

Evidence

References

part_of catalytic step 2 spliceosome

inferred from high throughput direct assay

(Herold et al., 2009)

part_of precatalytic spliceosome

inferred from high throughput direct assay

(Herold et al., 2009)

Terms Based on Predictions or Assertions (4 terms)

CV Term

Evidence

References

part_of catalytic step 2 spliceosome

inferred from biological aspect of ancestor with PANTHER:PTN000356711

(assigned by GO_Central )

(Gaudet et al., 2011)

part_of Prp19 complex

inferred from sequence or structural similarity with HGNC:17896

(FlyBase Curators, 2008--)

inferred from biological aspect of ancestor with PANTHER:PTN000356711

(assigned by GO_Central )

(Gaudet et al., 2011)

part_of spliceosomal complex

traceable author statement

(Milchanowski et al., 2004)

part_of U2-type catalytic step 1 spliceosome

inferred from biological aspect of ancestor with PANTHER:PTN000356711

(assigned by GO_Central )

(Gaudet et al., 2011)

Gene Group (FlyBase)

U-BOX UBIQUITIN LIGASES

SPLICEOSOME COMPLEX B

SPLICEOSOME COMPLEX C

SPLICEOSOME COMPLEX P

Protein Family (UniProt)

Protein Signatures (InterPro)

Summaries

Gene Snapshot

Pre-RNA processing factor 19 (Prp19) encodes a protein involved in chromatin organization and alternative mRNA splicing regulation. [Date last reviewed: 2019-07-11]

Gene Group (FlyBase)

U-BOX UBIQUITIN LIGASES -: E3 (ubiquitin) ligases interact with both ubiquitin-E2 (ubiquitin-conjugating) enzymes and the target protein, transferring the ubiquitin from the E2 to the substrate. U-box ubiquitin ligases (UULs) possess a domain structurally related the RING finger domain found in many E3s, but lacks Zn²⁺-co-ordinating residues. Some UULs have been found to possess E4 activity, co-ordinating with E1, E2 and E3 enzymes to transfer polyubiquitin to target proteins. (Adapted from PMID:20979629 and PMID:16250894).
SPLICEOSOME COMPLEX B -: Nuclear pre-mRNA splicing is catalyzed by the spliceosome which assembles in a step-wise manner. After the assembly of complex A on pre-mRNA, the U4-U6 and U5 snRNPs are recruited as a preassembled tri-snRNP to form complex B. U5 snRNP binds exons at the 5' site. (Adapted from PMID:24452469 and PMID:23118483).
SPLICEOSOME COMPLEX C -: Nuclear pre-mRNA splicing is catalyzed by the spliceosome which assembles in a step-wise manner. Complex B undergoes a number of structural rearrangements and U4 and U1 snRNPs dissociate to generate complex C, the catalytic spliceosome. (Adapted from PMID:24452469 and PMID:23118483).
SPLICEOSOME COMPLEX P -: Nuclear pre-mRNA splicing is catalyzed by the spliceosome which assembles in a step-wise manner. Complex P, the post-spliceosomal complex, is formed after the catalytic removal of the intron by complex C. Complex P contains the lariat intron and spliced exons. (Adapted from PMID:24452469 and PMID:23118483).

Gene Model and Products

Number of Transcripts

Number of Unique Polypeptides

Please see the JBrowse view of Dmel\Prp19 for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)

Isoform displayed:

Pfam protein domains

InterPro name

classification

start

end

Protein Domains (via SMART)

Isoform displayed:

SMART protein domains

InterPro name

classification

start

end

Comments on Gene Model

Gene model reviewed during 5.50

Sequence Ontology: Class of Gene

gene

nuclear_gene

protein_coding_gene

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Assoc. CDS (aa)

Prp19-RA

FBtr0086723

NM_079059

1757

505

Additional Transcript Data and Comments

Reported size (kB)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kDa)

Length (aa)

Theoretical pI

RefSeq ID

GenBank

Prp19-PA

FBpp0085902

55.2

505

6.90

NP_523783

AAF57684

Polypeptides with Identical Sequences

There is only one protein coding transcript and one polypeptide associated with this gene

Additional Polypeptide Data and Comments

Reported size (kDa)

Comments

External Data

Crossreferences

InterPro - A database of protein families, domains and functional sites

Linkouts

Sequences Consistent with the Gene Model

Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Prp19 using the Feature Mapper tool.

External Data

Crossreferences

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

Prp19_1

Linkouts

Expression Data

Expression Summary Ribbons

Colored tiles in ribbon indicate that expression data has been curated by FlyBase for that anatomical location. Colorless tiles indicate that there is no curated data for that location.

For complete stage-specific expression data, view the modENCODE Development RNA-Seq section under High-Throughput Expression below.

Transcript Expression

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Polypeptide Expression

mass spectroscopy

Stage

Tissue/Position (including subcellular localization)

Reference

adult stage

adult head

• membrane

(Aradska et al., 2015)

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Evidence

References

part_of catalytic step 2 spliceosome

inferred from high throughput direct assay

(Herold et al., 2009)

part_of precatalytic spliceosome

inferred from high throughput direct assay

(Herold et al., 2009)

Expression Deduced from Reporters

High-Throughput Expression Data

Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\Prp19 in GBrowse 2

RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region

View exonic expression by developmental stage for Dmel\Prp19

View exonic expression by tissue for Dmel\Prp19

Bulk Downloads

RNA-Seq RPKM values for all genes

Reference

See Gelbart and Emmert, 2013 for analysis details and data files for all genes.

Developmental Proteome: Life Cycle

Developmental Proteome: Embryogenesis

External Data and Images

Linkouts

FLIGHT - Cell culture data for RNAi and other high-throughput technologies

FBgn0261119

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG5519

Flygut - An atlas of the Drosophila adult midgut

FBgn0261119

Images

FlyBase Wiki

Image Based Resources

Alleles, Insertions, Transgenic Constructs, and Aberrations

Classical and Insertion Alleles ( 8 )

For All Classical and Insertion Alleles Show

Other relevant insertions

Transgenic Constructs ( 6 )

For All Alleles Carried on Transgenic Constructs Show

Transgenic constructs containing/affecting coding region of Prp19

Transgenic constructs containing regulatory region of Prp19

Aberrations (Deficiencies and Duplications) ( 4 )

Inferred from experimentation ( 4 )

Gene disrupted in

Df(2R)PC4

(Spradling et al., 1999, BDGP Project Members, 1994-1999)

Df(2R)PC29

(Spradling et al., 1999, BDGP Project Members, 1994-1999)

Df(2R)RM2-1

(Spradling et al., 1999, BDGP Project Members, 1994-1999)

Gene not disrupted in

Df(2R)P34

(Spradling et al., 1999, BDGP Project Members, 1994-1999)

Inferred from location ( 0 )

Phenotypes

For more details about a specific phenotype click on the relevant allele symbol.

Lethality

Allele

lethal, with Scer\GAL4^nub-AC-62

Prp19^HMS00652

lethal, with Scer\GAL4^pnr-MD237

Prp19^GD11681

lethal | female limited, with Scer\GAL4^dome-PG14

Prp19^HMS00652

lethal | pupal stage, with Scer\GAL4^pnr-MD237

Prp19^GD11681

viable, with Scer\GAL4^tin.CΔ4

Prp19^GD11681

Sterility

Allele

female sterile, with Scer\GAL4^VP16.otu

Prp19^HMS00652

Other Phenotypes

Allele

abnormal pain response | adult stage, with Dcr-2^UAS.cDa, Scer\GAL4^elav.PLu

Prp19^GD11681

abnormal size | third instar larval stage, with Scer\GAL4^Cg.PA

Prp19^HMS00652

long lived | female | RU486 conditional, with Scer\GAL4^da.Switch.PT

Prp19^UAS.cGa

long lived | female | RU486 conditional, with Scer\GAL4^{αTub84B.Switch.PK}

Prp19^UAS.cGa

Phenotype manifest in

Allele

chromatin, with Scer\GAL4^{VP16.mat.αTub67C}

Prp19^HMS00652

embryonic/larval fat body | third instar larval stage, with Scer\GAL4^Cg.PA

Prp19^HMS00652

mitochondrion | third instar larval stage, with Scer\GAL4^Cg.PA

Prp19^HMS00652

nucleolus, with Scer\GAL4^{VP16.mat.αTub67C}

Prp19^HMS00652

nurse cell, with Scer\GAL4^{VP16.mat.αTub67C}

Prp19^HMS00652

Orthologs

Downloads

Download All DIOPT Orthologs

Download All OrthoDB Orthologs

Human Orthologs (via DIOPT v8.0)

Homo sapiens (Human) (1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Hsap\PRPF19

15 of 15

Yes

Model Organism Orthologs (via DIOPT v8.0)

Mus musculus (laboratory mouse) (1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Mmus\Prpf19

14 of 15

Yes

Rattus norvegicus (Norway rat) (1)

Rnor\Prpf19

13 of 13

Yes

Xenopus tropicalis (Western clawed frog) (1)

Xtro\prpf19

13 of 12

Yes

Danio rerio (Zebrafish) (1)

Drer\prpf19

14 of 15

Yes

Caenorhabditis elegans (Nematode, roundworm) (1)

Cele\prp-19

13 of 15

Yes

Arabidopsis thaliana (thale-cress) (2)

Atha\MAC3A

9 of 9

Yes

Atha\MAC3B

9 of 9

Yes

Saccharomyces cerevisiae (Brewer's yeast) (1)

Scer\PRP19

8 of 15

Yes

Schizosaccharomyces pombe (Fission yeast) (1)

Spom\prp19

10 of 12

Yes

Ortholog(s) in Drosophila Species (via OrthoDB v9.1) ( EOG091906I1 )

Organism

Common Name

Gene

AAA Syntenic Ortholog

Multiple Dmel Genes in this Orthologous Group

Drosophila suzukii

Spotted wing Drosophila

Drosophila simulans

Drosophila sechellia

Drosophila erecta

Drosophila yakuba

Drosophila ananassae

Drosophila pseudoobscura pseudoobscura

Dpse\GA18945

Drosophila persimilis

Dper\GL16701

Drosophila willistoni

Dwil\GK23226

Drosophila virilis

Dvir\GJ22447

Drosophila mojavensis

Dmoj\GI19385

Drosophila grimshawi

Dgri\GH22157

Orthologs in non-Drosophila Dipterans (via OrthoDB v9.1) ( EOG091503E3 )

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Musca domestica

House fly

Mdoa\17005226

Glossina morsitans

Tsetse fly

Gmor\GMOY007119

Lucilia cuprina

Australian sheep blowfly

Lcup\FF38_09684

Mayetiola destructor

Hessian fly

Mdes\Mdes005412

Aedes aegypti

Yellow fever mosquito

Aaeg\AAEL015199

Aedes aegypti

Yellow fever mosquito

Aaeg\AAEL011535

Anopheles darlingi

American malaria mosquito

Adar\ADAC008770

Anopheles gambiae

Malaria mosquito

Agam\AGAP007217

Culex quinquefasciatus

Southern house mosquito

Cqui\CPIJ011261

Orthologs in non-Dipteran Insects (via OrthoDB v9.1) ( EOG090W04BN )

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Bombyx mori

Silkmoth

Bmor\BGIBMGA002837

Danaus plexippus

Monarch butterfly

Dple\DPOGS205952-PA

Heliconius melpomene

Postman butterfly

Hmel\HMEL006451

Apis florea

Little honeybee

Aflo\4567603684

Apis mellifera

Western honey bee

Amel\Prp19

Bombus impatiens

Common eastern bumble bee

Bimp\BIMP13942

Bombus terrestris

Buff-tailed bumblebee

Bter\15215330

Linepithema humile

Argentine ant

Lhum\LH16226

Megachile rotundata

Alfalfa leafcutting bee

Mrot\MROTU:000bd3

Nasonia vitripennis

Parasitic wasp

Nvit\Nasvi2EG032522

Nasonia vitripennis

Parasitic wasp

Nvit\Nasvi2EG006971

Dendroctonus ponderosae

Mountain pine beetle

Dpod\YQE_08537

Tribolium castaneum

Red flour beetle

Tcas\TC034425

Pediculus humanus

Human body louse

Phum\PHUM000240

Rhodnius prolixus

Kissing bug

Rpro\RPRC003922

Cimex lectularius

Bed bug

Clec\CLEC001819

Acyrthosiphon pisum

Pea aphid

Apim\ACYPI005525

Zootermopsis nevadensis

Nevada dampwood termite

Znev\Znev_03354

Orthologs in non-Insect Arthropods (via OrthoDB v9.1) ( EOG090X0489 )

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Strigamia maritima

European centipede

Smar\SMAR002869

Stegodyphus mimosarum

African social velvet spider

Smim\KFM80283.1

Tetranychus urticae

Two-spotted spider mite

Turt\tetur04g02280

Daphnia pulex

Water flea

Dpux\DAPPUDRAFT_303758

Orthologs in non-Arthropod Metazoa (via OrthoDB v9.1) ( EOG091G05AH )

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Strongylocentrotus purpuratus

Purple sea urchin

Spur\Sp-Prp19

Strongylocentrotus purpuratus

Purple sea urchin

Spur\Sp-Unk_4

Ciona intestinalis

Vase tunicate

Cint\ENSCING00000016625

Gallus gallus

Domestic chicken

Ggal\ENSGALG00000013919

Paralogs

Downloads

Download All DIOPT Paralogs

Paralogs (via DIOPT v8.0)

Drosophila melanogaster (Fruit fly) (2)

Gene Symbol

Score

Source

Alignment

1 of 10

1 of 10

Human Disease Associations

FlyBase Human Disease Model Reports

Disease Model Summary Ribbon

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Allele

Disease

Evidence

References

Potential Models Based on Orthology ( 0 )

Human Ortholog

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Allele

Disease

Interaction

References

Disease Associations of Human Orthologs (via DIOPT v8.0 and OMIM)

Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.

Homo sapiens (Human)

Gene name

Score

OMIM

OMIM Phenotype

DO term

Complementation?

Transgene?

PRPF19; pre-mRNA processing factor 19

15 of 15

608330

Functional Complementation Data

Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.

Interactions

Summary of Physical Interactions

esyN Network Diagram

Interactions Browser

View in Interactions Browser

Please see the Physical Interaction reports below for full details

protein-protein

Physical Interaction

Assay

References

Prp19 - BCAS2

anti tag coimmunoprecipitation, peptide massfingerprinting

(Guilgur et al., 2014)

Prp19 - Bx42

anti tag coimmunoprecipitation, peptide massfingerprinting

(Guilgur et al., 2014)

Prp19 - CG31368

anti tag coimmunoprecipitation, peptide massfingerprinting, western blot

(Rathore et al., 2020, Guilgur et al., 2014)

Prp19 - CG9667

anti tag coimmunoprecipitation, peptide massfingerprinting, anti bait coimmunoprecipitation, western blot

(Guilgur et al., 2014)

Prp19 - Cdc5

anti bait coimmunoprecipitation, western blot, anti tag coimmunoprecipitation, peptide massfingerprinting

(Guilgur et al., 2014)

Prp19 - Myc

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

Prp19 - Pi3K21B

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

Prp19 - RasGAP1

anti tag coimmunoprecipitation, peptide massfingerprinting

(Friedman et al., 2011)

Prp19 - S6kII

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

Prp19 - Tango4

anti tag coimmunoprecipitation, peptide massfingerprinting

(Guilgur et al., 2014)

Prp19 - Tsc1

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

Prp19 - U2af50

anti bait coimmunoprecipitation, western blot

(Minocha et al., 2018)

Prp19 - cyp33

anti tag coimmunoprecipitation, peptide massfingerprinting

(Guilgur et al., 2014)

Prp19 - fand

anti tag coimmunoprecipitation, peptide massfingerprinting, anti bait coimmunoprecipitation, western blot

(Minocha et al., 2018, Guilgur et al., 2014)

Prp19 - foxo

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

Prp19 - ft

anti tag coimmunoprecipitation, peptide massfingerprinting

(Kwon et al., 2013)

Prp19 - gig

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

Prp19 - rictor

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

Prp19 - sima

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

Summary of Genetic Interactions

esyN Network Diagram

esyN Network Key:

Suppression

Enhancement

View in Interactions Browser

Please look at the allele data for full details of the genetic interactions

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

cnk

enhanceable

Prp19

(Baril et al., 2014)

Ras85D

suppressible

Prp19

(Ashton-Beaucage et al., 2014)

enhanceable

Prp19

(Ashton-Beaucage et al., 2014)

External Data

Linkouts

BioGRID - A database of protein and genetic interactions.

62799

DroID - A comprehensive database of gene and protein interactions.

FBgn0261119

InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.

37123

MIST (protein-protein) - An integrated Molecular Interaction Database

Prp19

Pathways

Signaling Pathways (FlyBase)

Metabolic Pathways

External Data

Linkouts

KEGG Pathways - Wiring diagrams of molecular interactions, reactions and relations.

Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.

Genomic Location and Detailed Mapping Data

Chromosome (arm)

Recombination map

2-85

Cytogenetic map

55D1-55C9

Sequence location

2R:18,447,361..18,451,041 [-]

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

55D1-55C9

Left limit from in situ hybridisation (FBrf0067338) Right limit from in situ hybridisation (FBrf0067338); Limits computationally determined from genome sequence between P{lacW}l(2)08770^k04808 and P{EP}EP437

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

55D1-55D2

(determined by in situ hybridisation)

(Spradling et al., 1999)

55D1-55D2

(BDGP Project Members, 1994-1999)

Experimentally Determined Recombination Data

Location

2-85

(FlyBase, 2016)

2-89.9

(Comeron et al., 2012)

Left of (cM)

Right of (cM)

Notes

Stocks and Reagents

Stocks (6)

Bloomington

28455

y¹ w^*; P{EP}Prp19^G3080

32865

y¹ sc^* v¹ sev²¹; P{TRiP.HMS00652}attP2

79322

y¹ w^*; TI{CRIMIC.TG4.2}Prp19^{CR00856-TG4.2} CG30120^{CR00856-TG4.2-X} Lamtor2^{CR00856-TG4.2-X}/SM6a

VDRC

v108575

P{KK101335}VIE-260B

v41438

w¹¹¹⁸; P{GD11681}v41438

v318845

PBac{fTRG01327.sfGFP-TVPTBF}VK00033

Genomic Clones (14)

Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

cDNA Clones (52)

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequenced

BDGP DGC clones

LD02793

Other clones

Drosophila Genomics Resource Center cDNA clones

For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

FBgn0261119

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

Other clones

RNAi and Array Information

Linkouts

DRSC - Results frm RNAi screens

FBgn0261119

GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents

37123

Antibody Information

Laboratory Generated Antibodies

polyclonal

(Minocha et al., 2018, Guilgur et al., 2014)

Commercially Available Antibodies

Other Information

Relationship to Other Genes

Source for database identify of

Source for database merge of

Source for merge of: Prp19 CG5519

(Spradling et al., 1999)

Source for merge of: Gbp BcDNA:LD02793

(FlyBase, 1996-)

Additional comments

There is no evidence that CG5519 encodes a GTP binding protein. FBrf0122136 seems to have mis-identified it as a G-protein, based only on the fact that it has WD40 repeats. For these reasons, the FlyBase symbol/name for this gene has reverted from 'Gbp/GTP-binding-protein' to CG5519.

(Peifer, 2009.3.17)

Source for merge of Gbp BcDNA:LD02793 was sequence comparison ( date:000202 ).

(FlyBase, 1996-)

Identified only as a PCR sequence; identity to other GTP binding protein encoding genes unknown.

(Winge, 1995.3.30)

Other Comments

Origin and Etymology

Discoverer

Etymology

Identification

External Crossreferences and Linkouts ( 46 )

Sequence Crossreferences

NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.

37123

GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.

GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.

RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.

UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information

Other crossreferences

Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones

FBgn0261119

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

Prp19_1

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG5519

Flygut - An atlas of the Drosophila adult midgut

FBgn0261119

FlyMine - An integrated database for Drosophila genomics

FBgn0261119

GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents

37123

iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)

TC034425

InterPro - A database of protein families, domains and functional sites

KEGG Genes - Molecular building blocks of life in the genomic space.

Dmel_CG5519

modMine - A data warehouse for the modENCODE project

FBgn0261119

SignaLink - A signaling pathway resource with multi-layered regulatory networks.

Q24055

Linkouts

BioGRID - A database of protein and genetic interactions.

62799

DroID - A comprehensive database of gene and protein interactions.

FBgn0261119

DRSC - Results frm RNAi screens

FBgn0261119

FLIGHT - Cell culture data for RNAi and other high-throughput technologies

FBgn0261119

InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.

37123

KEGG Pathways - Wiring diagrams of molecular interactions, reactions and relations.

MIST (protein-protein) - An integrated Molecular Interaction Database

Prp19

Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.

Synonyms and Secondary IDs (13)

Reported As

Symbol Synonym

BcDNA:LD02793

CG5519

(Kolkhof et al., 2017, Hosono et al., 2015, Rosa-Ferreira et al., 2015, Guilgur et al., 2014, O'Keefe et al., 2011, Ying et al., 2011, Ni et al., 2010.12.1, Herold et al., 2009, Keleman et al., 2009.8.5, Andersen and Tapon, 2008, Haussmann et al., 2008, Hughes et al., 2008)

EC2-11

(Baril et al., 2014)

GPB

(Winge, 1995.3.30)

Gbp

(Herold et al., 2009, Fisher et al., 2008)

PRP19

(Marin, 2010)

dPrp19

(Garschall et al., 2017)

l(2)07838

(Beaton, 2000.1.31, Meister and Braun, 1995.10, BDGP Project Members, 1994-1999)

prp19

(Andersen and Tapon, 2008)

Name Synonyms

GTP-binding regulatory protein beta chain

(Winge, 1995.3.30)

NM 079059.2

(Marin, 2010)

Pre-RNA processing factor 19

Prp19

Secondary FlyBase IDs

FBgn0010644
FBgn0013969
FBgn0027900

Datasets (0)

Study focus (0)

Experimental Role

Project

Project Type

Title

References (78)

The following external sites may use different assemblies or annotations than FlyBase.

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