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Gene Dmel\Prp19

General Information
Symbol	Dmel\Prp19	Species	D. melanogaster
Name	Prp19	Annotation symbol	CG5519
Feature type	protein_coding_gene	FlyBase ID	FBgn0261119
Gene Model Status	Current	Stock availability	7 publicly available
Also Known As	l(2)07838, Gbp
Genomic Location
Chromosome (arm)	2R	Recombination map
Cytogenetic map	55D1-55C9	Sequence location	2R:14,334,866..14,338,546 [-]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents Beta	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene Prp19 is referred to in FlyBase by the symbol Dmel\Prp19 (CG5519, FBgn0261119). It is a protein_coding_gene from Drosophila melanogaster. An electronic pipeline based on InterPro domains suggests that it has the molecular function: ubiquitin-protein ligase activity. Based on sequence similarity, it is predicted to be involved in the biological process: mRNA splicing, via spliceosome. 5 alleles are reported. The phenotype of these alleles is annotated with: crystal cell. It has one annotated transcript and one annotated polypeptide. Protein features are: G-protein beta WD-40 repeat; Pre-mRNA-splicing factor 19; Quinonprotein alcohol dehydrogenase-like-superfamily; U box domain; WD40 repeat; WD40 repeat, conserved site; WD40-repeat-containing domain; WD40/YVTN repeat-like-containing domain; Zinc finger, RING/FYVE/PHD-type. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of very high expression to a trough of moderate expression. Peak expression observed within 00-12 hour embryonic stages. Summary of FlyAtlas Anatomical Expression Data: Nearly all larval and adult tissues/organs expressed at moderate levels. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, larval/adult central nervous system, adult crop, adult midgut, larval/adult hindgut, larval/adult Malpighian tubules, larval/adult fat body, larval/adult salivary gland, larval trachea, adult female reproductive system, adult male accessory gland, larval/adult carcass. Comments on Affy2 ProbeSet: ProbeSet 1622980_at completely aligns to an exonic region of the only FlyBase-annotated transcript isoform of Prp19. Gene sequence location is 2R:14334866..14338546.
User Contributed Data
	Beta version, feedback welcome
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 55D1-55C9   Left limit from in situ hybridisation (FBrf0067338) Right limit from in situ hybridisation (FBrf0067338); Limits computationally determined from genome sequence between P{lacW}l(2)08770k04808 and P{EP}EP437
Experimentally Determined Cytological Location
Cytogenetic map Notes References 55D1-55D2   (determined by in situ hybridisation)   (Spradling et al., 1999) 55D1-55D2     (BDGP Project Members, 1994-1999)
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\Prp19 for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
	Gene model reviewed during 5.50
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) Prp19-RA FBtr0086723  NM_079059   1757   505
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein Prp19-PA   FBpp0085902   55.2   505   6.90     NP_523783   AAF57684
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • WD40/YVTN repeat-like-containing domain (IPR015943) WD40-repeat-containing domain (IPR017986) WD40 repeat (IPR001680) U box domain (IPR003613) Pre-mRNA-splicing factor 19 (IPR013915) WD40 repeat, conserved site (IPR019775) G-protein beta WD-40 repeat (IPR020472) Zinc finger, RING/FYVE/PHD-type (IPR013083) Quinonprotein alcohol dehydrogenase-like superfamily (IPR011047)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA202633   AA390771   AA439603   AA440148   AA440989   AA567408   AA802594   AA817202   AA942369   AA948853   AA952090   AA978777   AE013599 AAF57684   AF160906 AAD46846   AI456366   AI515523   AI515614   AI519784   AI533275   BF493325   BF497285   BG635373   BG639225   BG639619   BI162073   BI162074   BI164390   BI166094   BI236105   BI240605   BI372402   BI373278   BI375944   BI486178   BI486393   BI486601   BI563547   BI575279   BI580655   BI624611   BI634661   BI634662   BI634682   BQ103660   BX061935   CO271021   CO300615   CO330607   EC090369   EC213770   EC217293   EC218888   EC231461   EC234658   EL883021   ES695591   ES695594   ES696405   ES696410   ES696422   ES696941   EV597182   EV599003   G00454   U23804 AAA65061
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL	Q7KLW9 Q24055
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Polypeptide Expression
Additional Descriptive Data
Marker for
Subcellular Localization (GO Cellular Component)
CV term Evidence References
catalytic step 2 spliceosome inferred from direct assay (Herold et al., 2009) microtubule associated complex inferred from direct assay (Hughes et al., 2008) precatalytic spliceosome inferred from direct assay (Herold et al., 2009)
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools
Reference	See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes.
FlyAtlas Anatomy Microarray
FlyAtlas Anatomical Expression Data (FlyAtlas-RNA.adult) (FlyAtlas-RNA.larva)    Styles Linear Logarithmic Heatmap Back-to-back    Scales gene max expression Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Nearly all larval and adult tissues/organs expressed at moderate levels. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, larval/adult central nervous system, adult crop, adult midgut, larval/adult hindgut, larval/adult Malpighian tubules, larval/adult fat body, larval/adult salivary gland, larval trachea, adult female reproductive system, adult male accessory gland, larval/adult carcass. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (>999.999) Linear, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    466.925 Larval Midgut    88.7 Larval Hindgut    156.2 Larval Malpighian Tubules    151.3 Larval Fat Body    117.5 Larval Salivary Gland    299.1 Larval Trachea    211.85 Larval Carcass    180.75 Adult Head    119.7 Adult Eye    87.9 Adult Brain    164.7 Adult Thoracic-Abdominal Ganglion    151 Adult Crop    149 Adult Midgut    144.5 Adult Hindgut    127.8 Adult Malpighian Tubules    131.5 Adult Fat Body    102.8 Adult Salivary Gland    147 Adult Heart    82.875 Adult VirginFemale Spermatheca    154.2 Adult InseminatedFemale Spermatheca    177.9 Adult Ovary    452.2 Adult Testis    46.7 Adult Male Accessory Gland    241.5 Adult Carcass    106.5 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    466.925 Larval Midgut    88.7 Larval Hindgut    156.2 Larval Malpighian Tubules    151.3 Larval Fat Body    117.5 Larval Salivary Gland    299.1 Larval Trachea    211.85 Larval Carcass    180.75 Adult Head    119.7 Adult Eye    87.9 Adult Brain    164.7 Adult Thoracic-Abdominal Ganglion    151 Adult Crop    149 Adult Midgut    144.5 Adult Hindgut    127.8 Adult Malpighian Tubules    131.5 Adult Fat Body    102.8 Adult Salivary Gland    147 Adult Heart    82.875 Adult VirginFemale Spermatheca    154.2 Adult InseminatedFemale Spermatheca    177.9 Adult Ovary    452.2 Adult Testis    46.7 Adult Male Accessory Gland    241.5 Adult Carcass    106.5 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    466.925 Larval Midgut    88.7 Larval Hindgut    156.2 Larval Malpighian Tubules    151.3 Larval Fat Body    117.5 Larval Salivary Gland    299.1 Larval Trachea    211.85 Larval Carcass    180.75 Adult Head    119.7 Adult Eye    87.9 Adult Brain    164.7 Adult Thoracic-Abdominal Ganglion    151 Adult Crop    149 Adult Midgut    144.5 Adult Hindgut    127.8 Adult Malpighian Tubules    131.5 Adult Fat Body    102.8 Adult Salivary Gland    147 Adult Heart    82.875 Adult VirginFemale Spermatheca    154.2 Adult InseminatedFemale Spermatheca    177.9 Adult Ovary    452.2 Adult Testis    46.7 Adult Male Accessory Gland    241.5 Adult Carcass    106.5 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    466.925 Larval Midgut    88.7 Larval Hindgut    156.2 Larval Malpighian Tubules    151.3 Larval Fat Body    117.5 Larval Salivary Gland    299.1 Larval Trachea    211.85 Larval Carcass    180.75 Adult Head    119.7 Adult Eye    87.9 Adult Brain    164.7 Adult Thoracic-Abdominal Ganglion    151 Adult Crop    149 Adult Midgut    144.5 Adult Hindgut    127.8 Adult Malpighian Tubules    131.5 Adult Fat Body    102.8 Adult Salivary Gland    147 Adult Heart    82.875 Adult VirginFemale Spermatheca    154.2 Adult InseminatedFemale Spermatheca    177.9 Adult Ovary    452.2 Adult Testis    46.7 Adult Male Accessory Gland    241.5 Adult Carcass    106.5 Expression Level Scale  Very high  log, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    466.925 Larval Midgut    88.7 Larval Hindgut    156.2 Larval Malpighian Tubules    151.3 Larval Fat Body    117.5 Larval Salivary Gland    299.1 Larval Trachea    211.85 Larval Carcass    180.75 Adult Head    119.7 Adult Eye    87.9 Adult Brain    164.7 Adult Thoracic-Abdominal Ganglion    151 Adult Crop    149 Adult Midgut    144.5 Adult Hindgut    127.8 Adult Malpighian Tubules    131.5 Adult Fat Body    102.8 Adult Salivary Gland    147 Adult Heart    82.875 Adult VirginFemale Spermatheca    154.2 Adult InseminatedFemale Spermatheca    177.9 Adult Ovary    452.2 Adult Testis    46.7 Adult Male Accessory Gland    241.5 Adult Carcass    106.5 Expression Level Scale  None   Low   Moderate   High  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    466.925 Larval Midgut    88.7 Larval Hindgut    156.2 Larval Malpighian Tubules    151.3 Larval Fat Body    117.5 Larval Salivary Gland    299.1 Larval Trachea    211.85 Larval Carcass    180.75 Adult Head    119.7 Adult Eye    87.9 Adult Brain    164.7 Adult Thoracic-Abdominal Ganglion    151 Adult Crop    149 Adult Midgut    144.5 Adult Hindgut    127.8 Adult Malpighian Tubules    131.5 Adult Fat Body    102.8 Adult Salivary Gland    147 Adult Heart    82.875 Adult VirginFemale Spermatheca    154.2 Adult InseminatedFemale Spermatheca    177.9 Adult Ovary    452.2 Adult Testis    46.7 Adult Male Accessory Gland    241.5 Adult Carcass    106.5 Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    466.925 Larval Midgut    88.7 Larval Hindgut    156.2 Larval Malpighian Tubules    151.3 Larval Fat Body    117.5 Larval Salivary Gland    299.1 Larval Trachea    211.85 Larval Carcass    180.75 Adult Head    119.7 Adult Eye    87.9 Adult Brain    164.7 Adult Thoracic-Abdominal Ganglion    151 Adult Crop    149 Adult Midgut    144.5 Adult Hindgut    127.8 Adult Malpighian Tubules    131.5 Adult Fat Body    102.8 Adult Salivary Gland    147 Adult Heart    82.875 Adult VirginFemale Spermatheca    154.2 Adult InseminatedFemale Spermatheca    177.9 Adult Ovary    452.2 Adult Testis    46.7 Adult Male Accessory Gland    241.5 Adult Carcass    106.5 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    466.925 Larval Midgut    88.7 Larval Hindgut    156.2 Larval Malpighian Tubules    151.3 Larval Fat Body    117.5 Larval Salivary Gland    299.1 Larval Trachea    211.85 Larval Carcass    180.75 Adult Head    119.7 Adult Eye    87.9 Adult Brain    164.7 Adult Thoracic-Abdominal Ganglion    151 Adult Crop    149 Adult Midgut    144.5 Adult Hindgut    127.8 Adult Malpighian Tubules    131.5 Adult Fat Body    102.8 Adult Salivary Gland    147 Adult Heart    82.875 Adult VirginFemale Spermatheca    154.2 Adult InseminatedFemale Spermatheca    177.9 Adult Ovary    452.2 Adult Testis    46.7 Adult Male Accessory Gland    241.5 Adult Carcass    106.5 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    119.7   NA  Eye    87.9   NA  Brain    164.7   466.925  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    151   NA  Crop    149   88.7  Midgut    144.5   156.2  Hindgut    127.8   151.3  Malpighian Tubules    131.5   117.5  Fat Body    102.8   299.1  Salivary Gland    147   NA  Heart    82.875   211.85  Trachea    NA   NA  VirginFemale Spermatheca    154.2   NA  InseminatedFemale Spermatheca    177.9   NA  Ovary    452.2   NA  Testis    46.7   NA  Male Accessory Gland    241.5   180.75  Carcass    106.5 FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
modENCODE Anatomy RNA-Seq
modENCODE Tissue Expression Data (modENCODE_mRNA-Seq_tissues)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    45 central nervous system, larvae L3    60 central nervous system, pupae P8    17 head, virgin 1-day female    10 head, virgin 4-day female    11 head, virgin 20-day female    12 head, mated 1-day female    8 head, mated 4-day female    8 head, mated 20-day female    10 head, mated 1-day male    10 head, mated 4-day male    11 head, mated 20-day male    13 salivary gland, larvae L3 wandering    2 salivary gland, white prepupae    4 digestive system, larvae L3 wandering    15 digestive system, 1-day adult    9 digestive system, 4-day adult    12 digestive system, 20-day adult    14 fat body, larvae L3 wandering    6 fat body, white prepupae    10 fat body, pupae P8    25 carcass, larvae L3 wandering    30 carcass, 1-day adult    7 carcass, 4-day adult    11 carcass, 20-day adult    13 ovary, virgin 4-day female    57 ovary, mated 4-day female    49 testis, mated 4-day male    6 accessory gland, mated 4-day male    10 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  Linear, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering  (45) central nervous system, larvae L3  (60) central nervous system, pupae P8    17 head, virgin 1-day female    10 head, virgin 4-day female    11 head, virgin 20-day female    12 head, mated 1-day female    8 head, mated 4-day female    8 head, mated 20-day female    10 head, mated 1-day male    10 head, mated 4-day male    11 head, mated 20-day male    13 salivary gland, larvae L3 wandering    2 salivary gland, white prepupae    4 digestive system, larvae L3 wandering    15 digestive system, 1-day adult    9 digestive system, 4-day adult    12 digestive system, 20-day adult    14 fat body, larvae L3 wandering    6 fat body, white prepupae    10 fat body, pupae P8    25 carcass, larvae L3 wandering  (30) carcass, 1-day adult    7 carcass, 4-day adult    11 carcass, 20-day adult    13 ovary, virgin 4-day female  (57) ovary, mated 4-day female  (49) testis, mated 4-day male    6 accessory gland, mated 4-day male    10 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    45 central nervous system, larvae L3    60 central nervous system, pupae P8    17 head, virgin 1-day female    10 head, virgin 4-day female    11 head, virgin 20-day female    12 head, mated 1-day female    8 head, mated 4-day female    8 head, mated 20-day female    10 head, mated 1-day male    10 head, mated 4-day male    11 head, mated 20-day male    13 salivary gland, larvae L3 wandering    2 salivary gland, white prepupae    4 digestive system, larvae L3 wandering    15 digestive system, 1-day adult    9 digestive system, 4-day adult    12 digestive system, 20-day adult    14 fat body, larvae L3 wandering    6 fat body, white prepupae    10 fat body, pupae P8    25 carcass, larvae L3 wandering    30 carcass, 1-day adult    7 carcass, 4-day adult    11 carcass, 20-day adult    13 ovary, virgin 4-day female    57 ovary, mated 4-day female    49 testis, mated 4-day male    6 accessory gland, mated 4-day male    10 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    45 central nervous system, larvae L3    60 central nervous system, pupae P8    17 head, virgin 1-day female    10 head, virgin 4-day female    11 head, virgin 20-day female    12 head, mated 1-day female    8 head, mated 4-day female    8 head, mated 20-day female    10 head, mated 1-day male    10 head, mated 4-day male    11 head, mated 20-day male    13 salivary gland, larvae L3 wandering    2 salivary gland, white prepupae    4 digestive system, larvae L3 wandering    15 digestive system, 1-day adult    9 digestive system, 4-day adult    12 digestive system, 20-day adult    14 fat body, larvae L3 wandering    6 fat body, white prepupae    10 fat body, pupae P8    25 carcass, larvae L3 wandering    30 carcass, 1-day adult    7 carcass, 4-day adult    11 carcass, 20-day adult    13 ovary, virgin 4-day female    57 ovary, mated 4-day female    49 testis, mated 4-day male    6 accessory gland, mated 4-day male    10 Expression Level Scale  Extremely high  log, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    45 central nervous system, larvae L3    60 central nervous system, pupae P8    17 head, virgin 1-day female    10 head, virgin 4-day female    11 head, virgin 20-day female    12 head, mated 1-day female    8 head, mated 4-day female    8 head, mated 20-day female    10 head, mated 1-day male    10 head, mated 4-day male    11 head, mated 20-day male    13 salivary gland, larvae L3 wandering    2 salivary gland, white prepupae    4 digestive system, larvae L3 wandering    15 digestive system, 1-day adult    9 digestive system, 4-day adult    12 digestive system, 20-day adult    14 fat body, larvae L3 wandering    6 fat body, white prepupae    10 fat body, pupae P8    25 carcass, larvae L3 wandering    30 carcass, 1-day adult    7 carcass, 4-day adult    11 carcass, 20-day adult    13 ovary, virgin 4-day female    57 ovary, mated 4-day female    49 testis, mated 4-day male    6 accessory gland, mated 4-day male    10 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  log, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering  (45) central nervous system, larvae L3  (60) central nervous system, pupae P8    17 head, virgin 1-day female    10 head, virgin 4-day female    11 head, virgin 20-day female    12 head, mated 1-day female    8 head, mated 4-day female    8 head, mated 20-day female    10 head, mated 1-day male    10 head, mated 4-day male    11 head, mated 20-day male    13 salivary gland, larvae L3 wandering    2 salivary gland, white prepupae    4 digestive system, larvae L3 wandering    15 digestive system, 1-day adult    9 digestive system, 4-day adult    12 digestive system, 20-day adult    14 fat body, larvae L3 wandering    6 fat body, white prepupae    10 fat body, pupae P8    25 carcass, larvae L3 wandering  30 carcass, 1-day adult    7 carcass, 4-day adult    11 carcass, 20-day adult    13 ovary, virgin 4-day female  (57) ovary, mated 4-day female  (49) testis, mated 4-day male    6 accessory gland, mated 4-day male    10 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    45 central nervous system, larvae L3    60 central nervous system, pupae P8    17 head, virgin 1-day female    10 head, virgin 4-day female    11 head, virgin 20-day female    12 head, mated 1-day female    8 head, mated 4-day female    8 head, mated 20-day female    10 head, mated 1-day male    10 head, mated 4-day male    11 head, mated 20-day male    13 salivary gland, larvae L3 wandering    2 salivary gland, white prepupae    4 digestive system, larvae L3 wandering    15 digestive system, 1-day adult    9 digestive system, 4-day adult    12 digestive system, 20-day adult    14 fat body, larvae L3 wandering    6 fat body, white prepupae    10 fat body, pupae P8    25 carcass, larvae L3 wandering    30 carcass, 1-day adult    7 carcass, 4-day adult    11 carcass, 20-day adult    13 ovary, virgin 4-day female    57 ovary, mated 4-day female    49 testis, mated 4-day male    6 accessory gland, mated 4-day male    10 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    45 central nervous system, larvae L3    60 central nervous system, pupae P8    17 head, virgin 1-day female    10 head, virgin 4-day female    11 head, virgin 20-day female    12 head, mated 1-day female    8 head, mated 4-day female    8 head, mated 20-day female    10 head, mated 1-day male    10 head, mated 4-day male    11 head, mated 20-day male    13 salivary gland, larvae L3 wandering    2 salivary gland, white prepupae    4 digestive system, larvae L3 wandering    15 digestive system, 1-day adult    9 digestive system, 4-day adult    12 digestive system, 20-day adult    14 fat body, larvae L3 wandering    6 fat body, white prepupae    10 fat body, pupae P8    25 carcass, larvae L3 wandering    30 carcass, 1-day adult    7 carcass, 4-day adult    11 carcass, 20-day adult    13 ovary, virgin 4-day female    57 ovary, mated 4-day female    49 testis, mated 4-day male    6 accessory gland, mated 4-day male    10 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Tissue   Expression Level imaginal disc, larvae L3 wandering     central nervous system, larvae L3     central nervous system, pupae P8     head, virgin 1-day female     head, virgin 4-day female     head, virgin 20-day female     head, mated 1-day female     head, mated 4-day female     head, mated 20-day female     head, mated 1-day male     head, mated 4-day male     head, mated 20-day male     salivary gland, larvae L3 wandering     salivary gland, white prepupae     digestive system, larvae L3 wandering     digestive system, 1-day adult     digestive system, 4-day adult     digestive system, 20-day adult     fat body, larvae L3 wandering     fat body, white prepupae     fat body, pupae P8     carcass, larvae L3 wandering     carcass, 1-day adult     carcass, 4-day adult     carcass, 20-day adult     ovary, virgin 4-day female     ovary, mated 4-day female     testis, mated 4-day male     accessory gland, mated 4-day male
modENCODE Development RNA-Seq
modENCODE Temporal Expression Data (modENCODE_mRNA-Seq_U)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of very high expression to a trough of moderate expression. Peak expression observed within 00-12 hour embryonic stages. [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    112 embryo 02-04hr    171 embryo 04-06hr    144 embryo 06-08hr    132 embryo 08-10hr    100 embryo 10-12hr    76 embryo 12-14hr    55 embryo 14-16hr    64 embryo 16-18hr    40 embryo 18-20hr    23 embryo 20-22hr    38 embryo 22-24hr    33 larva L1    42 larva L2    33 larva L3 12hr old    24 larva L3 puffstage 1-2    22 larva L3 puffstage 3-6    29 larva L3 puffstage 7-9    30 white prepupae new    30 white prepupae 12hr    32 white prepupae 24hr    35 pupae 2d postWPP    22 pupae 3d postWPP    10 pupae 4d postWPP    12 adult male 01day    10 adult male 05day    13 adult male 30day    14 adult female 01day    42 adult female 05day    57 adult female 30day    59 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (112) embryo 02-04hr  (171) embryo 04-06hr  (144) embryo 06-08hr  (132) embryo 08-10hr  (100) embryo 10-12hr  (76) embryo 12-14hr  (55) embryo 14-16hr  (64) embryo 16-18hr  (40) embryo 18-20hr    23 embryo 20-22hr  (38) embryo 22-24hr  (33) larva L1  (42) larva L2  (33) larva L3 12hr old    24 larva L3 puffstage 1-2    22 larva L3 puffstage 3-6  (29) larva L3 puffstage 7-9  (30) white prepupae new  (30) white prepupae 12hr  (32) white prepupae 24hr  (35) pupae 2d postWPP    22 pupae 3d postWPP    10 pupae 4d postWPP    12 adult male 01day    10 adult male 05day    13 adult male 30day    14 adult female 01day  (42) adult female 05day  (57) adult female 30day  (59) Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr  (112) embryo 02-04hr  (171) embryo 04-06hr  (144) embryo 06-08hr  (132) embryo 08-10hr    100 embryo 10-12hr    76 embryo 12-14hr    55 embryo 14-16hr    64 embryo 16-18hr    40 embryo 18-20hr    23 embryo 20-22hr    38 embryo 22-24hr    33 larva L1    42 larva L2    33 larva L3 12hr old    24 larva L3 puffstage 1-2    22 larva L3 puffstage 3-6    29 larva L3 puffstage 7-9    30 white prepupae new    30 white prepupae 12hr    32 white prepupae 24hr    35 pupae 2d postWPP    22 pupae 3d postWPP    10 pupae 4d postWPP    12 adult male 01day    10 adult male 05day    13 adult male 30day    14 adult female 01day    42 adult female 05day    57 adult female 30day    59 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    112 embryo 02-04hr    171 embryo 04-06hr    144 embryo 06-08hr    132 embryo 08-10hr    100 embryo 10-12hr    76 embryo 12-14hr    55 embryo 14-16hr    64 embryo 16-18hr    40 embryo 18-20hr    23 embryo 20-22hr    38 embryo 22-24hr    33 larva L1    42 larva L2    33 larva L3 12hr old    24 larva L3 puffstage 1-2    22 larva L3 puffstage 3-6    29 larva L3 puffstage 7-9    30 white prepupae new    30 white prepupae 12hr    32 white prepupae 24hr    35 pupae 2d postWPP    22 pupae 3d postWPP    10 pupae 4d postWPP    12 adult male 01day    10 adult male 05day    13 adult male 30day    14 adult female 01day    42 adult female 05day    57 adult female 30day    59 Expression Level Scale  Extremely high  log, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    112 embryo 02-04hr    171 embryo 04-06hr    144 embryo 06-08hr    132 embryo 08-10hr    100 embryo 10-12hr    76 embryo 12-14hr    55 embryo 14-16hr    64 embryo 16-18hr    40 embryo 18-20hr    23 embryo 20-22hr    38 embryo 22-24hr    33 larva L1    42 larva L2    33 larva L3 12hr old    24 larva L3 puffstage 1-2    22 larva L3 puffstage 3-6    29 larva L3 puffstage 7-9    30 white prepupae new    30 white prepupae 12hr    32 white prepupae 24hr    35 pupae 2d postWPP    22 pupae 3d postWPP    10 pupae 4d postWPP    12 adult male 01day    10 adult male 05day    13 adult male 30day    14 adult female 01day    42 adult female 05day    57 adult female 30day    59 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (112) embryo 02-04hr  (171) embryo 04-06hr  (144) embryo 06-08hr  (132) embryo 08-10hr  (100) embryo 10-12hr  (76) embryo 12-14hr  (55) embryo 14-16hr  (64) embryo 16-18hr  (40) embryo 18-20hr    23 embryo 20-22hr  (38) embryo 22-24hr  (33) larva L1  (42) larva L2  (33) larva L3 12hr old    24 larva L3 puffstage 1-2    22 larva L3 puffstage 3-6  29 larva L3 puffstage 7-9  30 white prepupae new  30 white prepupae 12hr  32 white prepupae 24hr  (35) pupae 2d postWPP    22 pupae 3d postWPP    10 pupae 4d postWPP    12 adult male 01day    10 adult male 05day    13 adult male 30day    14 adult female 01day  (42) adult female 05day  (57) adult female 30day  (59) Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr  112 embryo 02-04hr  (171) embryo 04-06hr  (144) embryo 06-08hr  132 embryo 08-10hr    100 embryo 10-12hr    76 embryo 12-14hr    55 embryo 14-16hr    64 embryo 16-18hr    40 embryo 18-20hr    23 embryo 20-22hr    38 embryo 22-24hr    33 larva L1    42 larva L2    33 larva L3 12hr old    24 larva L3 puffstage 1-2    22 larva L3 puffstage 3-6    29 larva L3 puffstage 7-9    30 white prepupae new    30 white prepupae 12hr    32 white prepupae 24hr    35 pupae 2d postWPP    22 pupae 3d postWPP    10 pupae 4d postWPP    12 adult male 01day    10 adult male 05day    13 adult male 30day    14 adult female 01day    42 adult female 05day    57 adult female 30day    59 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    112 embryo 02-04hr    171 embryo 04-06hr    144 embryo 06-08hr    132 embryo 08-10hr    100 embryo 10-12hr    76 embryo 12-14hr    55 embryo 14-16hr    64 embryo 16-18hr    40 embryo 18-20hr    23 embryo 20-22hr    38 embryo 22-24hr    33 larva L1    42 larva L2    33 larva L3 12hr old    24 larva L3 puffstage 1-2    22 larva L3 puffstage 3-6    29 larva L3 puffstage 7-9    30 white prepupae new    30 white prepupae 12hr    32 white prepupae 24hr    35 pupae 2d postWPP    22 pupae 3d postWPP    10 pupae 4d postWPP    12 adult male 01day    10 adult male 05day    13 adult male 30day    14 adult female 01day    42 adult female 05day    57 adult female 30day    59 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     modENCODE Temporal Expression Data (Graveley et al., 2011)
modENCODE Cell Lines RNA-Seq
modENCODE Cell Line Expression Data (modENCODE_mRNA-Seq_cell.A) (modENCODE_mRNA-Seq_cell.B)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    95 Schneider line 2 Sg4    53 embryonic 1182-4H    62 embryonic GM2    33 embryonic Kc167    29 embryonic S1    52 embryonic S3    55 leg disc CME L1    52 wing disc CME-W2    44 wing disc ML-DmD8    52 wing disc ML-DmD9    39 wing disc ML-DmD16-c3    47 wing disc ML-DmD21    54 wing disc ML-DmD32    28 haltere disc ML-DmD17-c3    76 eye-antennal disc ML-DmD11    56 antennal disc ML-DmD20-c5    59 mixed discs ML-DmD4-c1    51 CNS ML-DmBG1-c1    62 CNS ML-DmBG2-c2    47 tumorous blood cells mbn2    25 ovary fGS/OSS    44 ovary OSC    41 ovary OSS    20 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+  (95) Schneider line 2 Sg4  (53) embryonic 1182-4H  (62) embryonic GM2  (33) embryonic Kc167  (29) embryonic S1  (52) embryonic S3  (55) leg disc CME L1  (52) wing disc CME-W2  (44) wing disc ML-DmD8  (52) wing disc ML-DmD9  (39) wing disc ML-DmD16-c3  (47) wing disc ML-DmD21  (54) wing disc ML-DmD32  (28) haltere disc ML-DmD17-c3  (76) eye-antennal disc ML-DmD11  (56) antennal disc ML-DmD20-c5  (59) mixed discs ML-DmD4-c1  (51) CNS ML-DmBG1-c1  (62) CNS ML-DmBG2-c2  (47) tumorous blood cells mbn2    25 ovary fGS/OSS  (44) ovary OSC  (41) ovary OSS    20 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    95 Schneider line 2 Sg4    53 embryonic 1182-4H    62 embryonic GM2    33 embryonic Kc167    29 embryonic S1    52 embryonic S3    55 leg disc CME L1    52 wing disc CME-W2    44 wing disc ML-DmD8    52 wing disc ML-DmD9    39 wing disc ML-DmD16-c3    47 wing disc ML-DmD21    54 wing disc ML-DmD32    28 haltere disc ML-DmD17-c3    76 eye-antennal disc ML-DmD11    56 antennal disc ML-DmD20-c5    59 mixed discs ML-DmD4-c1    51 CNS ML-DmBG1-c1    62 CNS ML-DmBG2-c2    47 tumorous blood cells mbn2    25 ovary fGS/OSS    44 ovary OSC    41 ovary OSS    20 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    95 Schneider line 2 Sg4    53 embryonic 1182-4H    62 embryonic GM2    33 embryonic Kc167    29 embryonic S1    52 embryonic S3    55 leg disc CME L1    52 wing disc CME-W2    44 wing disc ML-DmD8    52 wing disc ML-DmD9    39 wing disc ML-DmD16-c3    47 wing disc ML-DmD21    54 wing disc ML-DmD32    28 haltere disc ML-DmD17-c3    76 eye-antennal disc ML-DmD11    56 antennal disc ML-DmD20-c5    59 mixed discs ML-DmD4-c1    51 CNS ML-DmBG1-c1    62 CNS ML-DmBG2-c2    47 tumorous blood cells mbn2    25 ovary fGS/OSS    44 ovary OSC    41 ovary OSS    20 Expression Level Scale  Extremely high  log, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    95 Schneider line 2 Sg4    53 embryonic 1182-4H    62 embryonic GM2    33 embryonic Kc167    29 embryonic S1    52 embryonic S3    55 leg disc CME L1    52 wing disc CME-W2    44 wing disc ML-DmD8    52 wing disc ML-DmD9    39 wing disc ML-DmD16-c3    47 wing disc ML-DmD21    54 wing disc ML-DmD32    28 haltere disc ML-DmD17-c3    76 eye-antennal disc ML-DmD11    56 antennal disc ML-DmD20-c5    59 mixed discs ML-DmD4-c1    51 CNS ML-DmBG1-c1    62 CNS ML-DmBG2-c2    47 tumorous blood cells mbn2    25 ovary fGS/OSS    44 ovary OSC    41 ovary OSS    20 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+  (95) Schneider line 2 Sg4  (53) embryonic 1182-4H  (62) embryonic GM2  (33) embryonic Kc167  29 embryonic S1  (52) embryonic S3  (55) leg disc CME L1  (52) wing disc CME-W2  (44) wing disc ML-DmD8  (52) wing disc ML-DmD9  (39) wing disc ML-DmD16-c3  (47) wing disc ML-DmD21  (54) wing disc ML-DmD32  28 haltere disc ML-DmD17-c3  (76) eye-antennal disc ML-DmD11  (56) antennal disc ML-DmD20-c5  (59) mixed discs ML-DmD4-c1  (51) CNS ML-DmBG1-c1  (62) CNS ML-DmBG2-c2  (47) tumorous blood cells mbn2    25 ovary fGS/OSS  (44) ovary OSC  (41) ovary OSS    20 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    95 Schneider line 2 Sg4    53 embryonic 1182-4H    62 embryonic GM2    33 embryonic Kc167    29 embryonic S1    52 embryonic S3    55 leg disc CME L1    52 wing disc CME-W2    44 wing disc ML-DmD8    52 wing disc ML-DmD9    39 wing disc ML-DmD16-c3    47 wing disc ML-DmD21    54 wing disc ML-DmD32    28 haltere disc ML-DmD17-c3    76 eye-antennal disc ML-DmD11    56 antennal disc ML-DmD20-c5    59 mixed discs ML-DmD4-c1    51 CNS ML-DmBG1-c1    62 CNS ML-DmBG2-c2    47 tumorous blood cells mbn2    25 ovary fGS/OSS    44 ovary OSC    41 ovary OSS    20 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    95 Schneider line 2 Sg4    53 embryonic 1182-4H    62 embryonic GM2    33 embryonic Kc167    29 embryonic S1    52 embryonic S3    55 leg disc CME L1    52 wing disc CME-W2    44 wing disc ML-DmD8    52 wing disc ML-DmD9    39 wing disc ML-DmD16-c3    47 wing disc ML-DmD21    54 wing disc ML-DmD32    28 haltere disc ML-DmD17-c3    76 eye-antennal disc ML-DmD11    56 antennal disc ML-DmD20-c5    59 mixed discs ML-DmD4-c1    51 CNS ML-DmBG1-c1    62 CNS ML-DmBG2-c2    47 tumorous blood cells mbn2    25 ovary fGS/OSS    44 ovary OSC    41 ovary OSS    20 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Cell Line   Expression Level Schneider line 2 S2R+     Schneider line 2 Sg4     embryonic 1182-4H     embryonic GM2     embryonic Kc167     embryonic S1     embryonic S3     leg disc CME L1     wing disc CME-W2     wing disc ML-DmD8     wing disc ML-DmD9     wing disc ML-DmD16-c3     wing disc ML-DmD21     wing disc ML-DmD32     haltere disc ML-DmD17-c3     eye-antennal disc ML-DmD11     antennal disc ML-DmD20-c5     mixed discs ML-DmD4-c1     CNS ML-DmBG1-c1     CNS ML-DmBG2-c2     tumorous blood cells mbn2     ovary fGS/OSS     ovary OSC     ovary OSS
modENCODE Treatments RNA-Seq
modENCODE Treatment Expression Data (modENCODE_mRNA-Seq_treatments)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    17 cold shock, 4-day adult    13 heat shock, 4-day adult    27 Cadmium 50 mM 6 hrs, larvae L3    20 Cadmium 50 mM 12 hrs, larvae L3    23 Cadmium 50 mM 48 hrs, 4-day adult    23 Cadmium 100 mM 48 hrs, 4-day adult    39 Copper 0.5 mM 12 hrs, larvae L3    13 Copper 15 mM 48 hrs, 4-day adult    44 Zinc 5 mM 12 hrs, larvae L3    9 Zinc 4.5 mM 48 hrs, 4-day adult    13 Ethanol 2.5% 3 hrs, larvae L3    47 Ethanol 5% 3 hrs, larvae L3    13 Ethanol 10% 3 hrs, larvae L3    17 Caffeine 1.5 mg/ml 4 hrs, larvae L3    11 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    37 Caffeine 25 mg/ml 48 hrs, 4-day adult    13 Paraquat 5 mM 48 hrs, 4-day adult    31 Paraquat 10 mM 48 hrs, 4-day adult    29 Rotenone 2 μg 12 hrs, larvae L3    20 Rotenone 8 μg 12 hrs, larvae L3    22 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  Linear, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult    17 cold shock, 4-day adult    13 heat shock, 4-day adult  (27) Cadmium 50 mM 6 hrs, larvae L3    20 Cadmium 50 mM 12 hrs, larvae L3    23 Cadmium 50 mM 48 hrs, 4-day adult    23 Cadmium 100 mM 48 hrs, 4-day adult  (39) Copper 0.5 mM 12 hrs, larvae L3    13 Copper 15 mM 48 hrs, 4-day adult  (44) Zinc 5 mM 12 hrs, larvae L3    9 Zinc 4.5 mM 48 hrs, 4-day adult    13 Ethanol 2.5% 3 hrs, larvae L3  (47) Ethanol 5% 3 hrs, larvae L3    13 Ethanol 10% 3 hrs, larvae L3    17 Caffeine 1.5 mg/ml 4 hrs, larvae L3    11 Caffeine 2.5 mg/ml 48 hrs, 4-day adult  (37) Caffeine 25 mg/ml 48 hrs, 4-day adult    13 Paraquat 5 mM 48 hrs, 4-day adult  (31) Paraquat 10 mM 48 hrs, 4-day adult  (29) Rotenone 2 μg 12 hrs, larvae L3    20 Rotenone 8 μg 12 hrs, larvae L3    22 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    17 cold shock, 4-day adult    13 heat shock, 4-day adult    27 Cadmium 50 mM 6 hrs, larvae L3    20 Cadmium 50 mM 12 hrs, larvae L3    23 Cadmium 50 mM 48 hrs, 4-day adult    23 Cadmium 100 mM 48 hrs, 4-day adult    39 Copper 0.5 mM 12 hrs, larvae L3    13 Copper 15 mM 48 hrs, 4-day adult    44 Zinc 5 mM 12 hrs, larvae L3    9 Zinc 4.5 mM 48 hrs, 4-day adult    13 Ethanol 2.5% 3 hrs, larvae L3    47 Ethanol 5% 3 hrs, larvae L3    13 Ethanol 10% 3 hrs, larvae L3    17 Caffeine 1.5 mg/ml 4 hrs, larvae L3    11 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    37 Caffeine 25 mg/ml 48 hrs, 4-day adult    13 Paraquat 5 mM 48 hrs, 4-day adult    31 Paraquat 10 mM 48 hrs, 4-day adult    29 Rotenone 2 μg 12 hrs, larvae L3    20 Rotenone 8 μg 12 hrs, larvae L3    22 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    17 cold shock, 4-day adult    13 heat shock, 4-day adult    27 Cadmium 50 mM 6 hrs, larvae L3    20 Cadmium 50 mM 12 hrs, larvae L3    23 Cadmium 50 mM 48 hrs, 4-day adult    23 Cadmium 100 mM 48 hrs, 4-day adult    39 Copper 0.5 mM 12 hrs, larvae L3    13 Copper 15 mM 48 hrs, 4-day adult    44 Zinc 5 mM 12 hrs, larvae L3    9 Zinc 4.5 mM 48 hrs, 4-day adult    13 Ethanol 2.5% 3 hrs, larvae L3    47 Ethanol 5% 3 hrs, larvae L3    13 Ethanol 10% 3 hrs, larvae L3    17 Caffeine 1.5 mg/ml 4 hrs, larvae L3    11 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    37 Caffeine 25 mg/ml 48 hrs, 4-day adult    13 Paraquat 5 mM 48 hrs, 4-day adult    31 Paraquat 10 mM 48 hrs, 4-day adult    29 Rotenone 2 μg 12 hrs, larvae L3    20 Rotenone 8 μg 12 hrs, larvae L3    22 Expression Level Scale  Extremely high  log, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    17 cold shock, 4-day adult    13 heat shock, 4-day adult    27 Cadmium 50 mM 6 hrs, larvae L3    20 Cadmium 50 mM 12 hrs, larvae L3    23 Cadmium 50 mM 48 hrs, 4-day adult    23 Cadmium 100 mM 48 hrs, 4-day adult    39 Copper 0.5 mM 12 hrs, larvae L3    13 Copper 15 mM 48 hrs, 4-day adult    44 Zinc 5 mM 12 hrs, larvae L3    9 Zinc 4.5 mM 48 hrs, 4-day adult    13 Ethanol 2.5% 3 hrs, larvae L3    47 Ethanol 5% 3 hrs, larvae L3    13 Ethanol 10% 3 hrs, larvae L3    17 Caffeine 1.5 mg/ml 4 hrs, larvae L3    11 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    37 Caffeine 25 mg/ml 48 hrs, 4-day adult    13 Paraquat 5 mM 48 hrs, 4-day adult    31 Paraquat 10 mM 48 hrs, 4-day adult    29 Rotenone 2 μg 12 hrs, larvae L3    20 Rotenone 8 μg 12 hrs, larvae L3    22 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  log, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult    17 cold shock, 4-day adult    13 heat shock, 4-day adult  27 Cadmium 50 mM 6 hrs, larvae L3    20 Cadmium 50 mM 12 hrs, larvae L3    23 Cadmium 50 mM 48 hrs, 4-day adult    23 Cadmium 100 mM 48 hrs, 4-day adult  (39) Copper 0.5 mM 12 hrs, larvae L3    13 Copper 15 mM 48 hrs, 4-day adult  (44) Zinc 5 mM 12 hrs, larvae L3    9 Zinc 4.5 mM 48 hrs, 4-day adult    13 Ethanol 2.5% 3 hrs, larvae L3  (47) Ethanol 5% 3 hrs, larvae L3    13 Ethanol 10% 3 hrs, larvae L3    17 Caffeine 1.5 mg/ml 4 hrs, larvae L3    11 Caffeine 2.5 mg/ml 48 hrs, 4-day adult  (37) Caffeine 25 mg/ml 48 hrs, 4-day adult    13 Paraquat 5 mM 48 hrs, 4-day adult  31 Paraquat 10 mM 48 hrs, 4-day adult  29 Rotenone 2 μg 12 hrs, larvae L3    20 Rotenone 8 μg 12 hrs, larvae L3    22 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    17 cold shock, 4-day adult    13 heat shock, 4-day adult    27 Cadmium 50 mM 6 hrs, larvae L3    20 Cadmium 50 mM 12 hrs, larvae L3    23 Cadmium 50 mM 48 hrs, 4-day adult    23 Cadmium 100 mM 48 hrs, 4-day adult    39 Copper 0.5 mM 12 hrs, larvae L3    13 Copper 15 mM 48 hrs, 4-day adult    44 Zinc 5 mM 12 hrs, larvae L3    9 Zinc 4.5 mM 48 hrs, 4-day adult    13 Ethanol 2.5% 3 hrs, larvae L3    47 Ethanol 5% 3 hrs, larvae L3    13 Ethanol 10% 3 hrs, larvae L3    17 Caffeine 1.5 mg/ml 4 hrs, larvae L3    11 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    37 Caffeine 25 mg/ml 48 hrs, 4-day adult    13 Paraquat 5 mM 48 hrs, 4-day adult    31 Paraquat 10 mM 48 hrs, 4-day adult    29 Rotenone 2 μg 12 hrs, larvae L3    20 Rotenone 8 μg 12 hrs, larvae L3    22 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    17 cold shock, 4-day adult    13 heat shock, 4-day adult    27 Cadmium 50 mM 6 hrs, larvae L3    20 Cadmium 50 mM 12 hrs, larvae L3    23 Cadmium 50 mM 48 hrs, 4-day adult    23 Cadmium 100 mM 48 hrs, 4-day adult    39 Copper 0.5 mM 12 hrs, larvae L3    13 Copper 15 mM 48 hrs, 4-day adult    44 Zinc 5 mM 12 hrs, larvae L3    9 Zinc 4.5 mM 48 hrs, 4-day adult    13 Ethanol 2.5% 3 hrs, larvae L3    47 Ethanol 5% 3 hrs, larvae L3    13 Ethanol 10% 3 hrs, larvae L3    17 Caffeine 1.5 mg/ml 4 hrs, larvae L3    11 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    37 Caffeine 25 mg/ml 48 hrs, 4-day adult    13 Paraquat 5 mM 48 hrs, 4-day adult    31 Paraquat 10 mM 48 hrs, 4-day adult    29 Rotenone 2 μg 12 hrs, larvae L3    20 Rotenone 8 μg 12 hrs, larvae L3    22 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Treatment   Expression Level extended cold, 4-day adult     cold shock, 4-day adult     heat shock, 4-day adult     Cadmium 50 mM 6 hrs, larvae L3     Cadmium 50 mM 12 hrs, larvae L3     Cadmium 50 mM 48 hrs, 4-day adult     Cadmium 100 mM 48 hrs, 4-day adult     Copper 0.5 mM 12 hrs, larvae L3     Copper 15 mM 48 hrs, 4-day adult     Zinc 5 mM 12 hrs, larvae L3     Zinc 4.5 mM 48 hrs, 4-day adult     Ethanol 2.5% 3 hrs, larvae L3     Ethanol 5% 3 hrs, larvae L3     Ethanol 10% 3 hrs, larvae L3     Caffeine 1.5 mg/ml 4 hrs, larvae L3     Caffeine 2.5 mg/ml 48 hrs, 4-day adult     Caffeine 25 mg/ml 48 hrs, 4-day adult     Paraquat 5 mM 48 hrs, 4-day adult     Paraquat 10 mM 48 hrs, 4-day adult     Rotenone 2 μg 12 hrs, larvae L3     Rotenone 8 μg 12 hrs, larvae L3
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (Graveley et al., 2011) mE1_20_mRNA_expression_cluster_03
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0261119
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele lethal, with Scer\GAL4pnr-MD237 Prp19GD11681 lethal | pupal stage, with Scer\GAL4pnr-MD237 Prp19GD11681 lethal | recessive Prp1907838 Phenotype manifest in Allele crystal cell Prp1907838
Classical Alleles ( 2 )
For All Classical Alleles Show
Allele of Prp19 Class Mutagen Stocks Known lesion Prp1907838 P-element activity 1 -- Prp19G3080 P-element activity 1 --
Alleles Carried on Transgenic Constructs ( 3 )
For All Alleles Carried on Transgenic Constructs Show
Allele of Prp19 Class Mutagen Stocks Known lesion Prp19GD11681 in vitro construct - RNAi in vitro construct - regulatory fusion 3 Yes Prp19HMS00652 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes Prp19KK101335 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes
Aneuploid Aberrations
Disrupted in	Df(2R)PC4 (Spradling et al., 1999, BDGP Project Members, 1994-1999) Df(2R)PC29 (Spradling et al., 1999, BDGP Project Members, 1994-1999) Df(2R)RM2-1 (Spradling et al., 1999, BDGP Project Members, 1994-1999)
Not disrupted in	Df(2R)P34 (Spradling et al., 1999, BDGP Project Members, 1994-1999)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{KK101335} NA P{TRiP.HMS00652} NA
Insertions
	Type of insertions Name Expression data insertion of enhancer trap P{PZ}Prp1907838 No insertion of mobile activating element P{EP}Prp19G3080 NA
Gene Ontology: Function, Process & Cellular Component ( 8 unique terms )
Terms Based on Experimental Evidence ( 3 terms )
Molecular Function ( 0 terms)
Biological Process ( 0 terms)
Cellular Component
CV term Evidence References
catalytic step 2 spliceosome inferred from direct assay (Herold et al., 2009) microtubule associated complex inferred from direct assay (Hughes et al., 2008) precatalytic spliceosome inferred from direct assay (Herold et al., 2009)
Terms Based on Predictions or Assertions ( 5 terms )
Molecular Function
CV term Evidence References
ubiquitin-protein ligase activity inferred from electronic annotation with InterPro:IPR003613 (FlyBase Curators et al., 2004-)
Biological Process
CV term Evidence References
mRNA splicing, via spliceosome inferred by curator from GO:0071011|GO:0071013 (Herold et al., 2009) inferred from sequence or structural similarity (Spradling et al., 1999) traceable author statement (Milchanowski et al., 2004) protein ubiquitination inferred from electronic annotation with InterPro:IPR003613 (FlyBase Curators et al., 2004-)
Cellular Component
CV term Evidence References
spliceosomal complex inferred from sequence or structural similarity (Spradling et al., 1999) traceable author statement (Milchanowski et al., 2004) ubiquitin ligase complex inferred from electronic annotation with InterPro:IPR003613 (FlyBase Curators et al., 2004-)
Sequence Ontology: Class of Gene
	gene   nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions Prp19 allele Gene References
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 62799 DroID - A comprehensive database of gene and protein interactions. • FBgn0261119 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 37123 SignaLink - A protein-protein and protein-miRNA interaction database with multi-layered structure and multiple confidence scores. • Q24055
Orthologs
OrthoDB Orthologs (40) - based on analysis using Dmel annotation version 5.41
OrthoDB Ortholog Groups
	OrthoDB orthology group searches (Waterhouse et al., 2011, Nucleic Acids Res. 39(Database issue): D283--D288) Drosophila inclusive ortholog search EOG64QTKM Dipteran inclusive ortholog search EOG69PB6S Insect inclusive ortholog search EOG6K997J Arthropod inclusive ortholog search EOG6DBRVZ Metazoa inclusive ortholog search EOG6QVR5J
Orthologs in Drosophila Species (EOG64QTKM)
Organism Common Name Gene AAA Syntenic Ortholog Multiple Dmel Genes in this Orthologous Group Drosophila melanogaster fruit fly  Dmel\Prp19     Drosophila simulans   Dsim\GD25391 Y   Drosophila sechellia   Dsec\GM19905 Y   Drosophila erecta   Dere\GG20970 Y   Drosophila yakuba   Dyak\GE13910 Y   Drosophila ananassae   Dana\GF12947 Y   Drosophila pseudoobscura pseudoobscura   Dpse\GA18945 Y   Drosophila persimilis   Dper\GL16701 Y   Drosophila willistoni   Dwil\GK23226 Y   Drosophila virilis   Dvir\GJ22447 Y   Drosophila mojavensis   Dmoj\GI19385 Y   Drosophila grimshawi   Dgri\GH22157 Y
Orthologs in non-Drosophila Dipterans (EOG69PB6S)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Aedes aegypti Yellow fever mosquito  Aaeg\AAEL015199   Aedes aegypti Yellow fever mosquito  Aaeg\AAEL011535   Anopheles gambiae Malaria mosquito  Agam\AGAP007217   Culex quinquefasciatus Southern house mosquito  Cqui\CPIJ011261
Orthologs in non-Dipteran Insects (EOG6K997J)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Apis mellifera Western honey bee  Amel\Prp19   Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG032522   Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG006971   Acromyrmex echinatior Panamanian leafcutter ant  Aech\AECH14705   Atta cephalotes Leafcutter ant  Acep\ACEP24108   Camponotus floridanus Florida carpenter ant  Cflo\CFLO17433   Harpegnathos saltator Jerdons jumping ant  Hsal\HSAL20224   Linepithema humile Argentine ant  Lhum\LH16226   Pogonomyrmex barbatus Red harvester ant  Pbar\PB12550   Solenopsis invicta Red fire ant  Sinv\SINV12103   Acyrthosiphon pisum Pea aphid  Apim\ACYPI005525   Bombyx mori Silkmoth  Bmor\BGIBMGA002837   Pediculus humanus Human body louse  Phum\PHUM000240   Tribolium castaneum Red flour beetle  Tcas\TC012659
Orthologs in non-Insect Arthropods (EOG6DBRVZ)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Daphnia pulex Water flea  Dpux\JGI_V11_303758
Orthologs in non-Arthropod Metazoa (EOG6QVR5J)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Caenorhabditis elegans Nematode  Cele\T10F2.4   Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_003744gn   Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_003743gn   Danio rerio Zebrafish  Drer\prp19   Xenopus tropicalis Western clawed frog  Xtro\prpf19   Gallus gallus Domestic chicken  Ggal\ENSGALG00000013919   Mus musculus House mouse  Mmus\Prpf19   Rattus norvegicus Norway rat  Rnor\ENSRNOG00000020897   Homo sapiens Human  Hsap\PRPF19
Human Orthologs (1)
Gene OMIM HGNC Hsap\PRPF19
AAA Orthologs (11) based on analysis using Dmel annotation version 4.3
Organism Gene Drosophila simulans Dsim\GD25391 Drosophila sechellia Dsec\GM19905 Drosophila erecta Dere\GG20970 Drosophila yakuba Dyak\GE13910 Drosophila ananassae Dana\GF12947 Drosophila pseudoobscura pseudoobscura Dpse\GA18945 Drosophila persimilis Dper\GL16701 Drosophila willistoni Dwil\GK23226 Drosophila virilis Dvir\GJ22447 Drosophila mojavensis Dmoj\GI19385 Drosophila grimshawi Dgri\GH22157
Stocks & Reagents
Stocks Listed in FlyBase ( 7 )
Bloomington	28455 y1 w*; P{EP}Prp19G3080 12346 P{PZ}Prp1907838 cn1/CyO; ry506 32865 y1 sc* v1; P{TRiP.HMS00652}attP2
VDRC	v108575 P{KK101335}VIE-260B v22146 w1118; P{GD11681}v22146 v22147 w1118; P{GD11681}v22147 v41438 w1118; P{GD11681}v41438
Genomic Clones ( 1 )
	BACR48A20 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 52 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	LD02793
Other clones
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	AT01653 AT11427 AT31940 GM05881 HL01142 LD08810 LD14214 LD14747 LD15707 LD22378 LD26529 LD27519 LD29139 LD32933 LD36344 LD39558 LD47510 RE04056 RE06121 RE32108 RE37484 RE59354 RE60535 RE63852 RE69566 RE69819 RE70051 RE74872 RH30537 RH34196 RH38862 RH38863 RH38886 RH64203 SD03490 SD05035
Other clones	57583 104095 193000 CK01.6D.C12 CK01.82B.E4 CK01.110D.D5 Dmel_neb_015907_0880_1018 Dmel_neb_016025_0939_3382 EK101615 EK178813 EK295711 IP12719 LD47390 RE01492 UUGC1070
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0261119 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 37123
Antibody Information
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of
Source for database merge of	Source for merge of: Gbp BcDNA:LD02793 (FlyBase, 1996-) Source for merge of: Prp19 CG5519 (Spradling et al., 1999)
Additional comments	There is no evidence that CG5519 encodes a GTP binding protein. FBrf0122136 seems to have mis-identified it as a G-protein, based only on the fact that it has WD40 repeats. For these reasons, the FlyBase symbol/name for this gene has reverted from 'Gbp/GTP-binding-protein' to CG5519. (Peifer, 2009.3.17) Source for merge of Gbp BcDNA:LD02793 was sequence comparison (date:000202). (FlyBase, 1996-) Identified only as a PCR sequence; identity to other GTP binding protein encoding genes unknown. (Winge, 1995.3.30)
Other Comments
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_079059 RefSeq (Proteins) • NP_523783 DDBJ / EMBL / GenBank • AA202633 AA390771 AAA65061 AAD46846 AAF57684 AF160906 G00454 U23804 Entrez Gene - A searchable database of RefSeq genes. • 37123 UniProtKB/TrEMBL • Q7KLW9 Q24055
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • WD40/YVTN repeat-like-containing domain (IPR015943) WD40-repeat-containing domain (IPR017986) WD40 repeat (IPR001680) U box domain (IPR003613) Pre-mRNA-splicing factor 19 (IPR013915) WD40 repeat, conserved site (IPR019775) G-protein beta WD-40 repeat (IPR020472) Zinc finger, RING/FYVE/PHD-type (IPR013083) Quinonprotein alcohol dehydrogenase-like superfamily (IPR011047)
Linkouts
	BioGRID - A database of protein and genetic interactions • 62799 DroID - A comprehensive database of gene and protein interactions. • FBgn0261119 DRSC - Results from RNAi screens. • FBgn0261119 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0261119 FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0261119 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 37123 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 37123 modMine - Data generated by the modENCODE project. • FBgn0261119 SignaLink - A protein-protein and protein-miRNA interaction database with multi-layered structure and multiple confidence scores. • Q24055
Synonyms & Secondary IDs ( 8 )
Reported As
Symbol Synonym	BcDNA:LD02793   CG5519 (O'Keefe et al., 2011, Andersen and Tapon, 2008, Keleman et al., 2009.8.5, Herold et al., 2009, Hughes et al., 2008, Haussmann et al., 2008, Ni et al., 2010.12.1) Gbp (Herold et al., 2009, Fisher et al., 2008) GPB (Winge, 1995.3.30) l(2)07838 (Beaton, 2000.1.31, Meister and Braun, 1995.10, BDGP Project Members, 1994-1999, ) Prp19 (O'Keefe et al., 2011, Avet-Rochex et al., 2010) prp19 (Andersen and Tapon, 2008)
Name Synonym	GTP-binding regulatory protein beta chain (Winge, 1995.3.30) Prp19
Secondary FlyBase IDs
	FBgn0010644 FBgn0013969 FBgn0027900
References ( 29 )
Generate a list of	All references relating to this gene ( 29 )
List References by type	Research paper  ( 10 ) Supplementary material  ( 3 ) Personal communication to FlyBase  ( 10 ) FlyBase analysis  ( 3 ) DNA/RNA sequence record  ( 1 ) Curated genome annotation  ( 2 )
Recent research papers ( 1 )
	O'Keefe et al., 2011, Hum. Mol. Genet. 20(3): 497--509 Drosophila orthologue of WWOX, the chromosomal fragile site FRA16D tumour suppressor gene, functions in aerobic metabolism and regulates reactive oxygen species. [FBrf0212691] Show all research papers ...