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Gene Dmel\Prp19

General Information
Symbol	Dmel\Prp19	Species	D. melanogaster
Name	Prp19	Annotation symbol	CG5519
Feature type	protein_coding_gene	FlyBase ID	FBgn0261119
Gene Model Status	Current	Stock availability	7 publicly available
Also Known As	l(2)07838
Genomic Location
Chromosome (arm)	2R	Recombination map
Cytogenetic map	55D1-55C9	Sequence location	2R:14,334,860..14,338,545 [-]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents modENCODE GBrowse	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene Prp19 is referred to in FlyBase by the symbol Dmel\Prp19 (CG5519, FBgn0261119). It is a protein_coding_gene from Drosophila melanogaster. An electronic pipeline based on InterPro domains suggests that it has the molecular function: ubiquitin-protein ligase activity. Based on sequence similarity, it is predicted to be involved in the biological process: nuclear mRNA splicing, via spliceosome. 5 alleles are reported. The phenotype of these alleles is annotated with: crystal cell. It has one annotated transcript and one annotated polypeptide. Protein features are: G-protein beta WD-40 repeat; Pre-mRNA-splicing factor 19; Quinonprotein alcohol dehydrogenase-like; U box domain; WD40 repeat; WD40 repeat 2; WD40 repeat, conserved site; WD40 repeat, subgroup; WD40 repeat-like-containing domain; WD40-repeat-containing domain; WD40/YVTN repeat-like-containing domain; Zinc finger, RING/FYVE/PHD-type. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of very high expression to a trough of moderate expression. Peak expression observed within 00-12 hour embryonic stages. Summary of FlyAtlas Anatomical Expression Data: Nearly all larval and adult tissues/organs expressed at moderate levels. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, larval/adult central nervous system, adult crop, adult midgut, larval/adult hindgut, larval/adult Malpighian tubules, larval/adult fat body, larval/adult salivary gland, larval trachea, adult female reproductive system, adult male accessory gland, larval/adult carcass. Comments on Affy2 ProbeSet: ProbeSet 1622980_at completely aligns to an exonic region of the only FlyBase-annotated transcript isoform of Prp19. Gene sequence location is 2R:14334860..14338545.
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2011_10
FB2012_01	Sequence features HFA07434 BKN21386
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 55D1-55C9   Left limit from in situ hybridisation (FBrf0067338) Right limit from in situ hybridisation (FBrf0067338); Limits computationally determined from genome sequence between P{lacW}l(2)08770k04808 and P{EP}EP437
Experimentally Determined Cytological Location
Cytogenetic map Notes References 55D1-55D2   (determined by in situ hybridisation)   (Spradling et al., 1999) 55D1-55D2     (BDGP Project Members, 1994-1999)
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\Prp19 for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) Prp19-RA FBtr0086723  NM_079059   1762   505
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein Prp19-PA   FBpp0085902   55.2   505   6.90     NP_523783   AAF57684
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • WD40/YVTN repeat-like-containing domain (IPR015943) WD40-repeat-containing domain (IPR017986) WD40 repeat (IPR001680) U box domain (IPR003613) WD40 repeat-like-containing domain (IPR011046) Pre-mRNA-splicing factor 19 (IPR013915) WD40 repeat, subgroup (IPR019781) WD40 repeat 2 (IPR019782) WD40 repeat, conserved site (IPR019775) G-protein beta WD-40 repeat (IPR020472) Quinonprotein alcohol dehydrogenase-like (IPR011047) Zinc finger, RING/FYVE/PHD-type (IPR013083)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA202633   AA390771   AA439603   AA440148   AA440989   AA567408   AA802594   AA817202   AA942369   AA948853   AA952090   AA978777   AE013599 AAF57684   AF160906 AAD46846   AI456366   AI515523   AI515614   AI519784   AI533275   BF493325   BF497285   BG635373   BG639225   BG639619   BI162073   BI162074   BI164390   BI166094   BI236105   BI240605   BI372402   BI373278   BI375944   BI486178   BI486393   BI486601   BI563547   BI575279   BI580655   BI624611   BI634661   BI634662   BI634682   BQ103660   BX061935   CO271021   CO300615   CO330607   EC090369   EC213770   EC217293   EC218888   EC231461   EC234658   EL883021   ES695591   ES695594   ES696405   ES696410   ES696422   ES696941   EV597182   EV599003   G00454   U23804 AAA65061
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL	Q24055 Q7KLW9
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
Polypeptide Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
High-Throughput Expression Data
or
See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes. modENCODE Temporal Expression Data for FBgn0261119    Styles Linear Logarithmic Heatmap    Scales max expr for FBgn0261119 Very low expression bin max Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of very high expression to a trough of moderate expression. Peak expression observed within 00-12 hour embryonic stages. [download data (TSV)] Guide to modENCODE expression level colors   No expression (0 - 0)   Extremely low expression (1 - 10)   Very low expression (11 - 100)   Low expression (101 - 400)   Moderate expression (401 - 1400)   Moderately high expression (1401 - 4000)   High expression (4001 - 10000)   Very high expression (10001 - 100000)   Extremely high expression (100001 - 2000000) Linear, scaled to maximum FBgn0261119 expression level Developmental Stage   Expression Level embryo 00-02hr    8525 embryo 02-04hr    13008 embryo 04-06hr    10948 embryo 06-08hr    10015 embryo 08-10hr    7603 embryo 10-12hr    5754 embryo 12-14hr    4171 embryo 14-16hr    4853 embryo 16-18hr    3037 embryo 18-20hr    1761 embryo 20-22hr    2861 embryo 22-24hr    2536 larva L1    3204 larva L2    2541 larva L3 12hr old    1851 larva L3 puffstage 1-2    1644 larva L3 puffstage 3-6    2182 larva L3 puffstage 7-9    2285 white prepupae new    2278 white prepupae 12hr    2435 white prepupae 24hr    2651 pupae 2d postWPP    1636 pupae 3d postWPP    770 pupae 4d postWPP    895 adult male 01day    780 adult male 05day    983 adult male 30day    1081 adult female 01day    3159 adult female 05day    4320 adult female 30day    4455 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (8525) embryo 02-04hr  (13008) embryo 04-06hr  (10948) embryo 06-08hr  (10015) embryo 08-10hr  (7603) embryo 10-12hr  (5754) embryo 12-14hr  (4171) embryo 14-16hr  (4853) embryo 16-18hr  (3037) embryo 18-20hr  (1761) embryo 20-22hr  (2861) embryo 22-24hr  (2536) larva L1  (3204) larva L2  (2541) larva L3 12hr old  (1851) larva L3 puffstage 1-2  (1644) larva L3 puffstage 3-6  (2182) larva L3 puffstage 7-9  (2285) white prepupae new  (2278) white prepupae 12hr  (2435) white prepupae 24hr  (2651) pupae 2d postWPP  (1636) pupae 3d postWPP  (770) pupae 4d postWPP  (895) adult male 01day  (780) adult male 05day  (983) adult male 30day  (1081) adult female 01day  (3159) adult female 05day  (4320) adult female 30day  (4455) Expression Level Scale  None   Extremely low   Very low   Low  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (8525) embryo 02-04hr  (13008) embryo 04-06hr  (10948) embryo 06-08hr  (10015) embryo 08-10hr  (7603) embryo 10-12hr  (5754) embryo 12-14hr  (4171) embryo 14-16hr  (4853) embryo 16-18hr  (3037) embryo 18-20hr  (1761) embryo 20-22hr  (2861) embryo 22-24hr  (2536) larva L1  (3204) larva L2  (2541) larva L3 12hr old  (1851) larva L3 puffstage 1-2  (1644) larva L3 puffstage 3-6  (2182) larva L3 puffstage 7-9  (2285) white prepupae new  (2278) white prepupae 12hr  (2435) white prepupae 24hr  (2651) pupae 2d postWPP  (1636) pupae 3d postWPP    770 pupae 4d postWPP    895 adult male 01day    780 adult male 05day    983 adult male 30day    1081 adult female 01day  (3159) adult female 05day  (4320) adult female 30day  (4455) Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    8525 embryo 02-04hr  (13008) embryo 04-06hr  (10948) embryo 06-08hr  10015 embryo 08-10hr    7603 embryo 10-12hr    5754 embryo 12-14hr    4171 embryo 14-16hr    4853 embryo 16-18hr    3037 embryo 18-20hr    1761 embryo 20-22hr    2861 embryo 22-24hr    2536 larva L1    3204 larva L2    2541 larva L3 12hr old    1851 larva L3 puffstage 1-2    1644 larva L3 puffstage 3-6    2182 larva L3 puffstage 7-9    2285 white prepupae new    2278 white prepupae 12hr    2435 white prepupae 24hr    2651 pupae 2d postWPP    1636 pupae 3d postWPP    770 pupae 4d postWPP    895 adult male 01day    780 adult male 05day    983 adult male 30day    1081 adult female 01day    3159 adult female 05day    4320 adult female 30day    4455 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    8525 embryo 02-04hr    13008 embryo 04-06hr    10948 embryo 06-08hr    10015 embryo 08-10hr    7603 embryo 10-12hr    5754 embryo 12-14hr    4171 embryo 14-16hr    4853 embryo 16-18hr    3037 embryo 18-20hr    1761 embryo 20-22hr    2861 embryo 22-24hr    2536 larva L1    3204 larva L2    2541 larva L3 12hr old    1851 larva L3 puffstage 1-2    1644 larva L3 puffstage 3-6    2182 larva L3 puffstage 7-9    2285 white prepupae new    2278 white prepupae 12hr    2435 white prepupae 24hr    2651 pupae 2d postWPP    1636 pupae 3d postWPP    770 pupae 4d postWPP    895 adult male 01day    780 adult male 05day    983 adult male 30day    1081 adult female 01day    3159 adult female 05day    4320 adult female 30day    4455 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  log, scaled to maximum FBgn0261119 expression level Developmental Stage   Expression Level embryo 00-02hr    8525 embryo 02-04hr    13008 embryo 04-06hr    10948 embryo 06-08hr    10015 embryo 08-10hr    7603 embryo 10-12hr    5754 embryo 12-14hr    4171 embryo 14-16hr    4853 embryo 16-18hr    3037 embryo 18-20hr    1761 embryo 20-22hr    2861 embryo 22-24hr    2536 larva L1    3204 larva L2    2541 larva L3 12hr old    1851 larva L3 puffstage 1-2    1644 larva L3 puffstage 3-6    2182 larva L3 puffstage 7-9    2285 white prepupae new    2278 white prepupae 12hr    2435 white prepupae 24hr    2651 pupae 2d postWPP    1636 pupae 3d postWPP    770 pupae 4d postWPP    895 adult male 01day    780 adult male 05day    983 adult male 30day    1081 adult female 01day    3159 adult female 05day    4320 adult female 30day    4455 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (8525) embryo 02-04hr  (13008) embryo 04-06hr  (10948) embryo 06-08hr  (10015) embryo 08-10hr  (7603) embryo 10-12hr  (5754) embryo 12-14hr  (4171) embryo 14-16hr  (4853) embryo 16-18hr  (3037) embryo 18-20hr  (1761) embryo 20-22hr  (2861) embryo 22-24hr  (2536) larva L1  (3204) larva L2  (2541) larva L3 12hr old  (1851) larva L3 puffstage 1-2  (1644) larva L3 puffstage 3-6  (2182) larva L3 puffstage 7-9  (2285) white prepupae new  (2278) white prepupae 12hr  (2435) white prepupae 24hr  (2651) pupae 2d postWPP  (1636) pupae 3d postWPP  (770) pupae 4d postWPP  (895) adult male 01day  (780) adult male 05day  (983) adult male 30day  (1081) adult female 01day  (3159) adult female 05day  (4320) adult female 30day  (4455) Expression Level Scale  None   Extremely low   Very low   Low  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (8525) embryo 02-04hr  (13008) embryo 04-06hr  (10948) embryo 06-08hr  (10015) embryo 08-10hr  (7603) embryo 10-12hr  (5754) embryo 12-14hr  (4171) embryo 14-16hr  (4853) embryo 16-18hr  (3037) embryo 18-20hr  1761 embryo 20-22hr  (2861) embryo 22-24hr  (2536) larva L1  (3204) larva L2  (2541) larva L3 12hr old  1851 larva L3 puffstage 1-2  1644 larva L3 puffstage 3-6  2182 larva L3 puffstage 7-9  2285 white prepupae new  2278 white prepupae 12hr  2435 white prepupae 24hr  (2651) pupae 2d postWPP  1636 pupae 3d postWPP    770 pupae 4d postWPP    895 adult male 01day    780 adult male 05day    983 adult male 30day    1081 adult female 01day  (3159) adult female 05day  (4320) adult female 30day  (4455) Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    8525 embryo 02-04hr  13008 embryo 04-06hr  10948 embryo 06-08hr  10015 embryo 08-10hr    7603 embryo 10-12hr    5754 embryo 12-14hr    4171 embryo 14-16hr    4853 embryo 16-18hr    3037 embryo 18-20hr    1761 embryo 20-22hr    2861 embryo 22-24hr    2536 larva L1    3204 larva L2    2541 larva L3 12hr old    1851 larva L3 puffstage 1-2    1644 larva L3 puffstage 3-6    2182 larva L3 puffstage 7-9    2285 white prepupae new    2278 white prepupae 12hr    2435 white prepupae 24hr    2651 pupae 2d postWPP    1636 pupae 3d postWPP    770 pupae 4d postWPP    895 adult male 01day    780 adult male 05day    983 adult male 30day    1081 adult female 01day    3159 adult female 05day    4320 adult female 30day    4455 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    8525 embryo 02-04hr    13008 embryo 04-06hr    10948 embryo 06-08hr    10015 embryo 08-10hr    7603 embryo 10-12hr    5754 embryo 12-14hr    4171 embryo 14-16hr    4853 embryo 16-18hr    3037 embryo 18-20hr    1761 embryo 20-22hr    2861 embryo 22-24hr    2536 larva L1    3204 larva L2    2541 larva L3 12hr old    1851 larva L3 puffstage 1-2    1644 larva L3 puffstage 3-6    2182 larva L3 puffstage 7-9    2285 white prepupae new    2278 white prepupae 12hr    2435 white prepupae 24hr    2651 pupae 2d postWPP    1636 pupae 3d postWPP    770 pupae 4d postWPP    895 adult male 01day    780 adult male 05day    983 adult male 30day    1081 adult female 01day    3159 adult female 05day    4320 adult female 30day    4455 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     FlyAtlas Anatomical Expression Data for FBgn0261119    Styles Linear Logarithmic Heatmap Back-to-back    Scales max expr for FBgn0261119 Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Nearly all larval and adult tissues/organs expressed at moderate levels. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, larval/adult central nervous system, adult crop, adult midgut, larval/adult hindgut, larval/adult Malpighian tubules, larval/adult fat body, larval/adult salivary gland, larval trachea, adult female reproductive system, adult male accessory gland, larval/adult carcass. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (1000 - 25000) Linear, scaled to maximum FBgn0261119 expression level Tissue   Expression Level Larval Central Nervous System    466.925 Larval Midgut    88.7 Larval Hindgut    156.2 Larval Malpighian Tubules    151.3 Larval Fat Body    117.5 Larval Salivary Gland    299.1 Larval Trachea    211.85 Larval Carcass    180.75 Adult Head    119.7 Adult Eye    87.9 Adult Brain    164.7 Adult Thoracic-Abdominal Ganglion    151 Adult Crop    149 Adult Midgut    144.5 Adult Hindgut    127.8 Adult Malpighian Tubules    131.5 Adult Fat Body    102.8 Adult Salivary Gland    147 Adult Heart    82.875 Adult VirginFemale Spermatheca    154.2 Adult InseminatedFemale Spermatheca    177.9 Adult Ovary    452.2 Adult Testis    46.7 Adult Male Accessory Gland    241.5 Adult Carcass    106.5 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    466.925 Larval Midgut    88.7 Larval Hindgut    156.2 Larval Malpighian Tubules    151.3 Larval Fat Body    117.5 Larval Salivary Gland    299.1 Larval Trachea    211.85 Larval Carcass    180.75 Adult Head    119.7 Adult Eye    87.9 Adult Brain    164.7 Adult Thoracic-Abdominal Ganglion    151 Adult Crop    149 Adult Midgut    144.5 Adult Hindgut    127.8 Adult Malpighian Tubules    131.5 Adult Fat Body    102.8 Adult Salivary Gland    147 Adult Heart    82.875 Adult VirginFemale Spermatheca    154.2 Adult InseminatedFemale Spermatheca    177.9 Adult Ovary    452.2 Adult Testis    46.7 Adult Male Accessory Gland    241.5 Adult Carcass    106.5 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    466.925 Larval Midgut    88.7 Larval Hindgut    156.2 Larval Malpighian Tubules    151.3 Larval Fat Body    117.5 Larval Salivary Gland    299.1 Larval Trachea    211.85 Larval Carcass    180.75 Adult Head    119.7 Adult Eye    87.9 Adult Brain    164.7 Adult Thoracic-Abdominal Ganglion    151 Adult Crop    149 Adult Midgut    144.5 Adult Hindgut    127.8 Adult Malpighian Tubules    131.5 Adult Fat Body    102.8 Adult Salivary Gland    147 Adult Heart    82.875 Adult VirginFemale Spermatheca    154.2 Adult InseminatedFemale Spermatheca    177.9 Adult Ovary    452.2 Adult Testis    46.7 Adult Male Accessory Gland    241.5 Adult Carcass    106.5 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    466.925 Larval Midgut    88.7 Larval Hindgut    156.2 Larval Malpighian Tubules    151.3 Larval Fat Body    117.5 Larval Salivary Gland    299.1 Larval Trachea    211.85 Larval Carcass    180.75 Adult Head    119.7 Adult Eye    87.9 Adult Brain    164.7 Adult Thoracic-Abdominal Ganglion    151 Adult Crop    149 Adult Midgut    144.5 Adult Hindgut    127.8 Adult Malpighian Tubules    131.5 Adult Fat Body    102.8 Adult Salivary Gland    147 Adult Heart    82.875 Adult VirginFemale Spermatheca    154.2 Adult InseminatedFemale Spermatheca    177.9 Adult Ovary    452.2 Adult Testis    46.7 Adult Male Accessory Gland    241.5 Adult Carcass    106.5 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to maximum FBgn0261119 expression level Tissue   Expression Level Larval Central Nervous System    466.925 Larval Midgut    88.7 Larval Hindgut    156.2 Larval Malpighian Tubules    151.3 Larval Fat Body    117.5 Larval Salivary Gland    299.1 Larval Trachea    211.85 Larval Carcass    180.75 Adult Head    119.7 Adult Eye    87.9 Adult Brain    164.7 Adult Thoracic-Abdominal Ganglion    151 Adult Crop    149 Adult Midgut    144.5 Adult Hindgut    127.8 Adult Malpighian Tubules    131.5 Adult Fat Body    102.8 Adult Salivary Gland    147 Adult Heart    82.875 Adult VirginFemale Spermatheca    154.2 Adult InseminatedFemale Spermatheca    177.9 Adult Ovary    452.2 Adult Testis    46.7 Adult Male Accessory Gland    241.5 Adult Carcass    106.5 Expression Level Scale  None   Low   Moderate   High  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    466.925 Larval Midgut    88.7 Larval Hindgut    156.2 Larval Malpighian Tubules    151.3 Larval Fat Body    117.5 Larval Salivary Gland    299.1 Larval Trachea    211.85 Larval Carcass    180.75 Adult Head    119.7 Adult Eye    87.9 Adult Brain    164.7 Adult Thoracic-Abdominal Ganglion    151 Adult Crop    149 Adult Midgut    144.5 Adult Hindgut    127.8 Adult Malpighian Tubules    131.5 Adult Fat Body    102.8 Adult Salivary Gland    147 Adult Heart    82.875 Adult VirginFemale Spermatheca    154.2 Adult InseminatedFemale Spermatheca    177.9 Adult Ovary    452.2 Adult Testis    46.7 Adult Male Accessory Gland    241.5 Adult Carcass    106.5 Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    466.925 Larval Midgut    88.7 Larval Hindgut    156.2 Larval Malpighian Tubules    151.3 Larval Fat Body    117.5 Larval Salivary Gland    299.1 Larval Trachea    211.85 Larval Carcass    180.75 Adult Head    119.7 Adult Eye    87.9 Adult Brain    164.7 Adult Thoracic-Abdominal Ganglion    151 Adult Crop    149 Adult Midgut    144.5 Adult Hindgut    127.8 Adult Malpighian Tubules    131.5 Adult Fat Body    102.8 Adult Salivary Gland    147 Adult Heart    82.875 Adult VirginFemale Spermatheca    154.2 Adult InseminatedFemale Spermatheca    177.9 Adult Ovary    452.2 Adult Testis    46.7 Adult Male Accessory Gland    241.5 Adult Carcass    106.5 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    466.925 Larval Midgut    88.7 Larval Hindgut    156.2 Larval Malpighian Tubules    151.3 Larval Fat Body    117.5 Larval Salivary Gland    299.1 Larval Trachea    211.85 Larval Carcass    180.75 Adult Head    119.7 Adult Eye    87.9 Adult Brain    164.7 Adult Thoracic-Abdominal Ganglion    151 Adult Crop    149 Adult Midgut    144.5 Adult Hindgut    127.8 Adult Malpighian Tubules    131.5 Adult Fat Body    102.8 Adult Salivary Gland    147 Adult Heart    82.875 Adult VirginFemale Spermatheca    154.2 Adult InseminatedFemale Spermatheca    177.9 Adult Ovary    452.2 Adult Testis    46.7 Adult Male Accessory Gland    241.5 Adult Carcass    106.5 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    119.7   NA  Eye    87.9   NA  Brain    164.7   466.925  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    151   NA  Crop    149   88.7  Midgut    144.5   156.2  Hindgut    127.8   151.3  Malpighian Tubules    131.5   117.5  Fat Body    102.8   299.1  Salivary Gland    147   NA  Heart    82.875   211.85  Trachea    NA   NA  VirginFemale Spermatheca    154.2   NA  InseminatedFemale Spermatheca    177.9   NA  Ovary    452.2   NA  Testis    46.7   NA  Male Accessory Gland    241.5   180.75  Carcass    106.5 modENCODE Temporal Expression Data (Graveley et al., 2011) FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
Expression Clusters
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0261119
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele lethal, with Scer\GAL4pnr-MD237 Prp19GD11681 lethal | pupal stage, with Scer\GAL4pnr-MD237 Prp19GD11681 lethal | recessive Prp1907838 Phenotype manifest in Allele crystal cell Prp1907838
Classical Alleles ( 2 )
For All Classical Alleles Show
Allele of Prp19 Class Mutagen Stocks Known lesion Prp1907838 P-element activity 1 -- Prp19G3080 P-element activity 1 --
Alleles Carried on Transgenic Constructs ( 3 )
For All Alleles Carried on Transgenic Constructs Show
Allele of Prp19 Class Mutagen Stocks Known lesion Prp19GD11681 in vitro construct - RNAi in vitro construct - regulatory fusion 3 Yes Prp19HMS00652 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes Prp19KK101335 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes
Aneuploid Aberrations
Disrupted in	Df(2R)PC4 (Spradling et al., 1999, BDGP Project Members, 1994-1999) Df(2R)PC29 (Spradling et al., 1999, BDGP Project Members, 1994-1999) Df(2R)RM2-1 (Spradling et al., 1999, BDGP Project Members, 1994-1999)
Not disrupted in	Df(2R)P34 (Spradling et al., 1999, BDGP Project Members, 1994-1999)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{KK101335} NA P{TRiP.HMS00652} NA
Insertions
	Type of insertions Name Expression data insertion of enhancer trap P{PZ}Prp1907838 No insertion of mobile activating element P{EP}Prp19G3080 NA
Gene Ontology: Function, Process & Cellular Component ( 8 unique terms )
Terms Based on Experimental Evidence ( 3 terms )
Molecular Function ( 0 terms)
Biological Process ( 0 terms)
Cellular Component
CV term Evidence References
catalytic step 2 spliceosome inferred from direct assay (Herold et al., 2009) microtubule associated complex inferred from direct assay (Hughes et al., 2008) precatalytic spliceosome inferred from direct assay (Herold et al., 2009)
Terms Based on Predictions or Assertions ( 5 terms )
Molecular Function
CV term Evidence References
ubiquitin-protein ligase activity inferred from electronic annotation with InterPro:IPR003613 (FlyBase Curators et al., 2004-)
Biological Process
CV term Evidence References
nuclear mRNA splicing, via spliceosome inferred by curator from GO:0071011|GO:0071013 (Herold et al., 2009) inferred from sequence or structural similarity (Spradling et al., 1999) traceable author statement (Milchanowski et al., 2004) protein ubiquitination inferred from electronic annotation with InterPro:IPR003613 (FlyBase Curators et al., 2004-)
Cellular Component
CV term Evidence References
spliceosomal complex inferred from sequence or structural similarity (Spradling et al., 1999) traceable author statement (Milchanowski et al., 2004) ubiquitin ligase complex inferred from electronic annotation with InterPro:IPR003613 (FlyBase Curators et al., 2004-)
Sequence Ontology: Class of Gene
	gene   nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Protein-protein
Interacting group Assay References
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions Prp19 allele Gene References
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 62799 DroID - A comprehensive database of gene and protein interactions. • FBgn0261119 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 37123
Orthologs
Genome-wide drosophilid orthologs	Dana\GF12947 Dere\GG20970 Dgri\GH22157 Dmoj\GI19385 Dper\GL16701 Dpse\GA18945 Dsec\GM19905 Dsim\GD25391 Dvir\GJ22447 Dwil\GK23226 Dyak\GE13910
Curated drosophilid orthologs	Dpse\GA18945
Linkouts	InParanoid A subset of ortholog calls from InParanoid. • AAEL011535-PA Aedes aegypti (mosquito) AAEL015199-PA Aedes aegypti (mosquito) AGAP007217-PA Anopheles gambiae (mosquito) XP_392284.2 Apis mellifera (honey bee) XP_001947999.1 Acyrthosiphon pisum (pea aphid) At2g33340.1 Arabidopsis thaliana (wall cress) 88622 Batrachochytrium dendrobatidis (chytrid fungus) 121774 Branchiostoma floridae (lancelet) XP_001894946.1 Brugia malayi (roundworm nematode) BGIBMGA002837-PA Bombyx mori (silk worm) ENSBTAP00000019100 Bos taurus (bovine) CAL0004852 Candida albicans (a form of yeast) CN27939 Caenorhabditis brenneri (small nematode) CBP11780 Caenorhabditis briggsae (nematode) CE38104 Caenorhabditis elegans (worm) ENSCAFP00000024195 Canis familiaris (dog) CAGL0D02772g Candida glabrata (haploid yeast) Chro.60560 Cryptosporidium hominis (obligate parasite) ENSCINP00000013139 Ciona intestinalis (sea squirt) JA14316 Caenorhabditis japonica (nematode) cn03492 Cryptococcus neoformans (yeast-like fungus) cgd6_4850 Cryptosporidium parvum (protozoan parasite) CPIJ011261 Culex pipens (mosquito) ENSCPOP00000020974 Cavia porcellus (guinea pig) 186412 Chlamidomonas reinhardtii (green alga) RP11742 Caenorhabditis remanei (nematode) ENSCSAVP00000003406 Ciona savignyi (sedentary tunicate) 184443 Capitella spl (polychaete worm) DDB0233121 Dictyostelium discoideum (amoeba) DEHA2F03058g Debaryomyces Hansenii (yeast) 303758 Daphnia pulex (daphnia) ENSDARP00000097371 Danio rerio (zebra fish) ENSECAP00000005876 Equus caballus (horse) ENSGACP00000023748 Gymnopilus aculeatus (mushroom) 186274 Hypsipyla robusta (cedar shoot borer) ENSP00000227524 Homo sapiens (human) 103711 Lottia gigantea (owl limpet) LmjF27.2480 Leishmania major (virus) 34443 Monocosta brevicollis (choanoflagellate) ENSMODP00000033460 Monodelphis domestica (gray opossum) ENSMMUP00000019079 Macaca mulatta (rhesus monkey) ENSMUSP00000025642 Mus musculus (house mouse) 199033 Nematostella vectensis (starlet anemone) XP_001599397.1 Nasonia vitripennis (wasp) ENSOANP00000015372 Ornithorynchus anatinus (platypus) ENSORLP00000005873 Oryzias latipes (japanese killifish) LOC_Os10g32880.1 Oryza sativa (asian rice) 10174 Ostreococcus tauri (green alga) PFC0365w Plasmodium falciparum (protozoal parasite) PHUM003755-PA Pediculus humanus (human body louse) PP21954 Pristionchus pacificus (nematode) 183278 Physcomitrella patens (moss) ENSPPYP00000003692 Pongo pygmaeus (orangutan) 72129 Phytophthora ramorum (sudden oak death pathogen) 108852 Phytophthora sojae (root rot pathogen) 820827 Populus trichocarpa (black cottonwood) ENSPTRP00000006406 Pan troglodytes (chimpanzee) PVX_119545 Plasmodium vivax (protozoal parasite) ENSRNOP00000028373 Rattus norvegicus (norway rat) 4869341 Sorghum bicolor (sorghum) Smp_167150 Schistosoma mansoni (trematode parasite) SPAC29A4.08c Schizosaccharomyces pombe (fission yeast) XP_787949.2 Strongylocentrotus purpuratus (purple sea urchin) 64168 Trichoplax adhaerens (metazoa) TA03395 Theileria annulata (apicomplexan parasite) XP_970005.1 Tribolium castaneum (red flour beetle) Tc00.1047053507801.60 Trypanosoma cruzi (parasitic trypanosome) Tc00.1047053509103.10 Trypanosoma cruzi (parasitic trypanosome) ENSTNIP00000017232 Tetraodon nigroviridis (green spotted pufferfish) TP03_0215 Theileria parva (parasitic protozoan) 25866 Thalassiosira pseudonana (marine diatom) ENSTRUP00000021300 Takifugu rubripes (pufferfish Takifugu) 3829.m01318 Tetrahymena thermophila (ciliate protozoa) ENSXETP00000026115 Xenopus tropicalis (frog) OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • PB12550 NV19039 LH16226 FBgn0231553 FBgn0225188 FBgn0209558 FBgn0196688 FBgn0174791 JGI_V11_303758 FBgn0078944 FBgn0154305 FBgn0142123 FBgn0129618 FBgn0113154 FBgn0089981 CPIJ011261 BGIBMGA002837 ACYPI005525 GB11480 AGAP007217 AAEL015199 AAEL011535 PHUM000240 GLEAN_12659
Stocks & Reagents
Stocks Listed in FlyBase ( 7 )
Bloomington	28455 y1 w*; P{EP}Prp19G3080 12346 P{PZ}Prp1907838 cn1/CyO; ry506 32865 y1 sc* v1; P{TRiP.HMS00652}attP2
VDRC	v108575 P{KK101335}VIE-260B v22146 w1118; P{GD11681}v22146 v22147 w1118; P{GD11681}v22147 v41438 w1118; P{GD11681}v41438
Genomic Clones ( 1 )
	BACR48A20 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 52 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	LD02793
Other clones
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	AT01653 AT11427 AT31940 GM05881 HL01142 LD08810 LD14214 LD14747 LD15707 LD22378 LD26529 LD27519 LD29139 LD32933 LD36344 LD39558 LD47510 RE04056 RE06121 RE32108 RE37484 RE59354 RE60535 RE63852 RE69566 RE69819 RE70051 RE74872 RH30537 RH34196 RH38862 RH38863 RH38886 RH64203 SD03490 SD05035
Other clones	57583 104095 193000 CK01.6D.C12 CK01.82B.E4 CK01.110D.D5 Dmel_neb_015907_0880_1018 Dmel_neb_016025_0939_3382 EK101615 EK178813 EK295711 IP12719 LD47390 RE01492 UUGC1070
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0261119 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 37123
Antibody Information
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of
Source for database merge of	Source for merge of: Gbp BcDNA:LD02793 (FlyBase, 1996-) Source for merge of: Prp19 CG5519 (Spradling et al., 1999)
Additional comments	There is no evidence that CG5519 encodes a GTP binding protein. FBrf0122136 seems to have mis-identified it as a G-protein, based only on the fact that it has WD40 repeats. For these reasons, the FlyBase symbol/name for this gene has reverted from 'Gbp/GTP-binding-protein' to CG5519. (Peifer, 2009.3.17) Source for merge of Gbp BcDNA:LD02793 was sequence comparison (date:000202). (FlyBase, 1996-) Identified only as a PCR sequence; identity to other GTP binding protein encoding genes unknown. (Winge, 1995.3.30)
Other Comments
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_079059 RefSeq (Proteins) • NP_523783 DDBJ / EMBL / GenBank • AA202633 AA390771 AAA65061 AAD46846 AAF57684 AF160906 G00454 U23804 Entrez Gene - A searchable database of RefSeq genes. • 37123 UniProtKB/TrEMBL • Q7KLW9 Q24055
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • WD40/YVTN repeat-like-containing domain (IPR015943) WD40-repeat-containing domain (IPR017986) WD40 repeat (IPR001680) U box domain (IPR003613) WD40 repeat-like-containing domain (IPR011046) Pre-mRNA-splicing factor 19 (IPR013915) WD40 repeat, subgroup (IPR019781) WD40 repeat 2 (IPR019782) WD40 repeat, conserved site (IPR019775) G-protein beta WD-40 repeat (IPR020472) Quinonprotein alcohol dehydrogenase-like (IPR011047) Zinc finger, RING/FYVE/PHD-type (IPR013083)
Linkouts
	BioGRID - A database of protein and genetic interactions • 62799 DroID - A comprehensive database of gene and protein interactions. • FBgn0261119 DRSC - Results from RNAi screens. • FBgn0261119 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0261119 FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0261119 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 37123 InParanoid A subset of ortholog calls from InParanoid. • AAEL011535-PA Aedes aegypti (mosquito) AAEL015199-PA Aedes aegypti (mosquito) AGAP007217-PA Anopheles gambiae (mosquito) XP_392284.2 Apis mellifera (honey bee) XP_001947999.1 Acyrthosiphon pisum (pea aphid) At2g33340.1 Arabidopsis thaliana (wall cress) 88622 Batrachochytrium dendrobatidis (chytrid fungus) 121774 Branchiostoma floridae (lancelet) XP_001894946.1 Brugia malayi (roundworm nematode) BGIBMGA002837-PA Bombyx mori (silk worm) ENSBTAP00000019100 Bos taurus (bovine) CAL0004852 Candida albicans (a form of yeast) CN27939 Caenorhabditis brenneri (small nematode) CBP11780 Caenorhabditis briggsae (nematode) CE38104 Caenorhabditis elegans (worm) ENSCAFP00000024195 Canis familiaris (dog) CAGL0D02772g Candida glabrata (haploid yeast) Chro.60560 Cryptosporidium hominis (obligate parasite) ENSCINP00000013139 Ciona intestinalis (sea squirt) JA14316 Caenorhabditis japonica (nematode) cn03492 Cryptococcus neoformans (yeast-like fungus) cgd6_4850 Cryptosporidium parvum (protozoan parasite) CPIJ011261 Culex pipens (mosquito) ENSCPOP00000020974 Cavia porcellus (guinea pig) 186412 Chlamidomonas reinhardtii (green alga) RP11742 Caenorhabditis remanei (nematode) ENSCSAVP00000003406 Ciona savignyi (sedentary tunicate) 184443 Capitella spl (polychaete worm) DDB0233121 Dictyostelium discoideum (amoeba) DEHA2F03058g Debaryomyces Hansenii (yeast) 303758 Daphnia pulex (daphnia) ENSDARP00000097371 Danio rerio (zebra fish) ENSECAP00000005876 Equus caballus (horse) ENSGACP00000023748 Gymnopilus aculeatus (mushroom) 186274 Hypsipyla robusta (cedar shoot borer) ENSP00000227524 Homo sapiens (human) 103711 Lottia gigantea (owl limpet) LmjF27.2480 Leishmania major (virus) 34443 Monocosta brevicollis (choanoflagellate) ENSMODP00000033460 Monodelphis domestica (gray opossum) ENSMMUP00000019079 Macaca mulatta (rhesus monkey) ENSMUSP00000025642 Mus musculus (house mouse) 199033 Nematostella vectensis (starlet anemone) XP_001599397.1 Nasonia vitripennis (wasp) ENSOANP00000015372 Ornithorynchus anatinus (platypus) ENSORLP00000005873 Oryzias latipes (japanese killifish) LOC_Os10g32880.1 Oryza sativa (asian rice) 10174 Ostreococcus tauri (green alga) PFC0365w Plasmodium falciparum (protozoal parasite) PHUM003755-PA Pediculus humanus (human body louse) PP21954 Pristionchus pacificus (nematode) 183278 Physcomitrella patens (moss) ENSPPYP00000003692 Pongo pygmaeus (orangutan) 72129 Phytophthora ramorum (sudden oak death pathogen) 108852 Phytophthora sojae (root rot pathogen) 820827 Populus trichocarpa (black cottonwood) ENSPTRP00000006406 Pan troglodytes (chimpanzee) PVX_119545 Plasmodium vivax (protozoal parasite) ENSRNOP00000028373 Rattus norvegicus (norway rat) 4869341 Sorghum bicolor (sorghum) Smp_167150 Schistosoma mansoni (trematode parasite) SPAC29A4.08c Schizosaccharomyces pombe (fission yeast) XP_787949.2 Strongylocentrotus purpuratus (purple sea urchin) 64168 Trichoplax adhaerens (metazoa) TA03395 Theileria annulata (apicomplexan parasite) XP_970005.1 Tribolium castaneum (red flour beetle) Tc00.1047053507801.60 Trypanosoma cruzi (parasitic trypanosome) Tc00.1047053509103.10 Trypanosoma cruzi (parasitic trypanosome) ENSTNIP00000017232 Tetraodon nigroviridis (green spotted pufferfish) TP03_0215 Theileria parva (parasitic protozoan) 25866 Thalassiosira pseudonana (marine diatom) ENSTRUP00000021300 Takifugu rubripes (pufferfish Takifugu) 3829.m01318 Tetrahymena thermophila (ciliate protozoa) ENSXETP00000026115 Xenopus tropicalis (frog) InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 37123 modMine - Data generated by the modENCODE project. • FBgn0261119 OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • PB12550 NV19039 LH16226 FBgn0231553 FBgn0225188 FBgn0209558 FBgn0196688 FBgn0174791 JGI_V11_303758 FBgn0078944 FBgn0154305 FBgn0142123 FBgn0129618 FBgn0113154 FBgn0089981 CPIJ011261 BGIBMGA002837 ACYPI005525 GB11480 AGAP007217 AAEL015199 AAEL011535 PHUM000240 GLEAN_12659
Synonyms & Secondary IDs ( 8 )
Reported As
Symbol Synonym	BcDNA:LD02793   CG5519 (O'Keefe et al., 2011, Andersen and Tapon, 2008, Keleman et al., 2009.8.5, Herold et al., 2009, Hughes et al., 2008, Haussmann et al., 2008, Ni et al., 2010.12.1) Gbp (Herold et al., 2009) GPB (Winge, 1995.3.30) l(2)07838 (Beaton, 2000.1.31, Meister and Braun, 1995.10, BDGP Project Members, 1994-1999, ) Prp19 (O'Keefe et al., 2011, Avet-Rochex et al., 2010) prp19 (Andersen and Tapon, 2008)
Name Synonym	GTP-binding regulatory protein beta chain (Winge, 1995.3.30) Prp19
Secondary FlyBase IDs
	FBgn0010644 FBgn0013969 FBgn0027900
References ( 27 )
Generate a list of	All references relating to this gene ( 27 )
List References by type	Research paper  ( 9 ) Supplementary material  ( 2 ) Personal communication to FlyBase  ( 8 ) FlyBase analysis  ( 3 ) Computer file  ( 2 ) DNA/RNA sequence record  ( 1 ) Curated genome annotation  ( 1 ) Automatic genome annotation  ( 1 )
Recent research papers ( 3 )
	O'Keefe et al., 2011, Hum. Mol. Genet. 20(3): 497--509 Drosophila orthologue of WWOX, the chromosomal fragile site FRA16D tumour suppressor gene, functions in aerobic metabolism and regulates reactive oxygen species. [FBrf0212691] Avet-Rochex et al., 2010, BMC Dev. Biol. 10: 65 An in vivo RNA interference screen identifies gene networks controlling Drosophila melanogaster blood cell homeostasis. [FBrf0211137] Blanco et al., 2010, BMC Dev. Biol. 10: 94 Gene expression following induction of regeneration in Drosophila wing imaginal discs. Expression profile of regenerating wing discs. [FBrf0211812] Show all research papers ...