DHR39, ftz-F1β, fs(2)04443, fs(2)neo8, NR5B1
Annotated transcripts do not represent all supported alternative splices within 5' UTR.
Low-frequency RNA-Seq exon junction(s) not annotated.
Gene model reviewed during 5.45
808, 701 (aa)
Monomer; forms a complex with ftz.
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Hr39 using the Feature Mapper tool.
Hr39 expression was studied in staged third instar larvae and prepupae collected at two hour intervals. Transcripts can first be detected in early third instar larvae and continue to be present at low levels until 106-108hr. After that, they accumulate to high levels, peaking in early prepupae. Hr39 transcripts drop in abundance in mid prepupae, rise again in 10hr prepupae, and continue to be present through the beginning of pupal development. In staged prepupal salivary glands, Hr39 transcripts are abundant at 0hr, decline in 2hr glands, and then are reintroduced, peaking 6-8hr after puparium formation. Hr39 transcripts are rapidly induced by ecdysone.
5kb Hr39 transcripts are present at all developmental stages. In embryos, transcripts are most abundant at 6-9 hr. Hr39 transcripts are detected in the stomodeum of stage 13 embryos. In stage 16 embryos, transcripts are most prominent in the central nervous system and in the brain lobes.
Hr39 3.5kb transcripts are most abundant in 0-3 hour embryos and are probably maternally inherited.
5.1kb Hr39 transcripts are not present in early embryos but are detected at all other stages of development. An elevated transcript level is observed during puparium formation. Transcripts are uniformly distributed in early embryos. At later stages, high levels of expression are observed in the ventral cord, brain, and hindgut.
GBrowse - Visual display of RNA-Seq signalsView Dmel\Hr39 in GBrowse 2
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
Source for merge of: Hr39 fs(2)neo8 fs(2)04443
Hr39 is involved in αbgr; axon guidance and fasciculation but is necessarily downregulated in γ axons for pruning to occur.
Temporal profile of gene expression is not altered in Eip74EF mutant background.
ftz-f1 and Hr39 bind as monomers to oligonucleotides corresponding to the ftz-f1 recognition element (F1RE) located within the zebra element of ftz promoter. Antagonism between the two receptors contributes to the net F1RE-dependent transcription of a reporter gene in cotransfection assays. Results suggest common target genes may be coregulated at the transcriptional level by a mechanism of competition between ftz-f1 and Hr39 monomers for binding to a common element.
Hr39 cloned by screening an expression library with oligonucleotide probe corresponding to the positive element of the Adh adult enhancer: DNA sequence analysis showed Hr39 belongs to the steroid hormone receptor superfamily. Whereas ftz-f1, which binds to the same sequence, acts as an activator of distal Adh transcription, Hr39 acts to repress distal Adh transcription.