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Gene Dmel\Fhos

General Information
Symbol	Dmel\Fhos	Species	D. melanogaster
Name		Annotation symbol	CG42610
Feature type	protein_coding_gene	FlyBase ID	FBgn0261259
Gene Model Status	Current	Stock availability	24 publicly available
Also Known As	CG32030, CG5797, CG5775
Genomic Location
Chromosome (arm)	3L	Recombination map
Cytogenetic map	66D12-66D15	Sequence location	3L:8,747,243..8,791,819 [+]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents modENCODE GBrowse	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	This gene is referred to in FlyBase by the symbol Dmel\Fhos (CG42610, FBgn0261259). It is a protein_coding_gene from Drosophila melanogaster. Based on sequence similarity, it is predicted to have molecular function: actin binding. An electronic pipeline based on InterPro domains suggests that it is involved in the biological process: actin cytoskeleton organization. 29 alleles are reported. No phenotypic data is available. It has 8 annotated transcripts and 8 annotated polypeptides. Protein features are: Actin-binding FH2; Actin-binding FH2/DRF autoregulatory; Armadillo-type fold; Diaphanous autoregulatory; GTPase-binding/formin homology 3. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of low expression. Peak expression observed within 12-18 embryonic stages, during late pupal stages, in stages of adults of both sexes. Summary of FlyAtlas Anatomical Expression Data: Two or more Affy2 ProbeSets identify exons of this gene. This is a summary of the tissue expression peaks exhibited in at least one of these ProbeSets. Expression at high levels in the following post-embryonic organs or tissues: adult carcass. Expression at moderate levels in the following post-embryonic organs or tissues: adult eye, adult crop, adult midgut, larval/adult hindgut, larval Malpighian tubules, larval/adult salivary gland, adult male accessory gland, larval carcass. Gene sequence location is 3L:8747243..8791819.
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
Update Feed	Click the icon below to subscribe to this FlyBase record and receive updates automatically through your feed reader.
FB2011_10	References Bellen, 2011.10.10, MISet953.xml Alleles Fhos[MI01421] Insertions Mi{MIC}Fhos[MI01421]
FB2012_01	Sequence features BKN31333 BKN28388 HFA10546 HFA08943 HFA10545 HFA10547
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 66D12-66D15   Limits computationally determined from genome sequence between P{PZ}SrpRβrK561&P{lacW}l(3)j5B6j5B6 and P{PZ}l(3)0162901629&P{PZ}mRpL1210534; Limits computationally determined from genome sequence between P{PZ}l(3)0162901629&P{PZ}mRpL1210534 and P{EP}Hsp26EP3336&P{EP}Hsp26EP3315
Experimentally Determined Cytological Location
Cytogenetic map Notes References 66D-66E     (Erkner, 1999.12.20)
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\Fhos for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
	Gene merge based on EST/cDNA
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) Fhos-RA FBtr0302085  NM_168293   5025   1393 Fhos-RB FBtr0302086  NM_168294   4345   1294 Fhos-RC FBtr0302087  NM_001169916   8393   2511 Fhos-RD FBtr0302583  NM_001202143   5620   1509 Fhos-RE FBtr0302584  NM_001202142   5157   1387 Fhos-RF FBtr0306630     4836   1205 Fhos-RG FBtr0306631     4302   1152 Fhos-RH FBtr0306632     6029   1744
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein Fhos-PA   FBpp0291295   155.9   1393   7.39     NP_729410   AAF50365 Fhos-PB   FBpp0291296   144.5   1294   6.90     NP_729411   AAF50366 Fhos-PC   FBpp0291297   277.4   2511   8.04     NP_001163387   ACZ94658 Fhos-PD   FBpp0291739   169.6   1509   8.63     NP_001189072   ADV37509 Fhos-PE   FBpp0291740   155.1   1387   7.62     NP_001189071   ADV37508 Fhos-PF   FBpp0297585   135.0   1205   8.32       Fhos-PG   FBpp0297586   129.7   1152   7.20       Fhos-PH   FBpp0297587   196.0   1744   5.86
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Actin-binding FH2/DRF autoregulatory (IPR003104) GTPase-binding/formin homology 3 (IPR014768) Actin-binding FH2 (IPR015425) Diaphanous autoregulatory (IPR014767) Armadillo-type fold (IPR016024)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA540550   AA817618   AA820261   AA941176   AA951744   AE014296 AAF50365   AE014296 AAF50366   AE014296 ACZ94658   AE014296 ADV37508   AE014296 ADV37509   AF217845 AAF34753   AI296059   AI455372   AI455425   AI542550   AW944574   AY075386 AAL68224   AY084212 AAL89950   BI239689   BI240405   BI484783   BI485066   BI639576   BT030139   BT050456   BT100020   CL526154   CO186358   CO186586   CO196355   CO265020   CO268646   CO269995   CO270070   CO270858   CO279563   CO280908   CO281571   CO284656   CO287443   CO289276   CO290095   CO291813   CO293795   CO298141   CO305112   CO307204   CO308588   CO308628   CO309735   CO326690   CO328756   CO332661   CO341858   CO342489   CO345238   CZ474646   CZ477086   CZ477087   CZ477773   CZ477774   CZ477891   CZ478335   CZ479551   CZ479552   CZ479570   CZ483146   CZ483559   CZ483560   CZ484350   CZ484351   CZ484455   CZ484456   CZ485363   CZ485364   CZ485603   CZ488903   CZ488904   CZ489685   CZ489686   EC059708   EC066093   EC071728   EC077709   EC086044   EC210788   EC221539   EC230744   EC239780   EC244520   EC247871   EC250638   EC251469   EC252315   EC253567   EL880420   EL886023   EL886024   EL886131   EL886132   EL886241   EL886242   ES696055   GH944479   GH944663   GH960121   GH980063   GH980258   GH981252
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL	Q8SY43 Q8T4F5 Q9VSQ0 Q9VSQ1 Q9NHX5 E1JI78
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
Polypeptide Expression
mass spectroscopy Stage Tissue/Position (including subcellular localization) Reference day 5 of adulthood & male -- day 7 of adulthood & male   spermatozoon   (Wasbrough et al., 2010) day 7 of adulthood -- day 49 of adulthood   adult heart   (Cammarato et al., 2011)
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
High-Throughput Expression Data
or
See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes. modENCODE Temporal Expression Data for FBgn0261259    Styles Linear Logarithmic Heatmap    Scales max expr for FBgn0261259 Very low expression bin max Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of low expression. Peak expression observed within 12-18 embryonic stages, during late pupal stages, in stages of adults of both sexes. [download data (TSV)] Guide to modENCODE expression level colors   No expression (0 - 0)   Extremely low expression (1 - 10)   Very low expression (11 - 100)   Low expression (101 - 400)   Moderate expression (401 - 1400)   Moderately high expression (1401 - 4000)   High expression (4001 - 10000)   Very high expression (10001 - 100000)   Extremely high expression (100001 - 2000000) Linear, scaled to maximum FBgn0261259 expression level Developmental Stage   Expression Level embryo 00-02hr    841 embryo 02-04hr    622 embryo 04-06hr    197 embryo 06-08hr    270 embryo 08-10hr    521 embryo 10-12hr    540 embryo 12-14hr    885 embryo 14-16hr    1611 embryo 16-18hr    2484 embryo 18-20hr    1324 embryo 20-22hr    758 embryo 22-24hr    665 larva L1    288 larva L2    423 larva L3 12hr old    525 larva L3 puffstage 1-2    524 larva L3 puffstage 3-6    814 larva L3 puffstage 7-9    1087 white prepupae new    1238 white prepupae 12hr    583 white prepupae 24hr    695 pupae 2d postWPP    1511 pupae 3d postWPP    3260 pupae 4d postWPP    1365 adult male 01day    3051 adult male 05day    2160 adult male 30day    1048 adult female 01day    1741 adult female 05day    902 adult female 30day    679 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  Linear, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (841) embryo 02-04hr  (622) embryo 04-06hr  (197) embryo 06-08hr  (270) embryo 08-10hr  (521) embryo 10-12hr  (540) embryo 12-14hr  (885) embryo 14-16hr  (1611) embryo 16-18hr  (2484) embryo 18-20hr  (1324) embryo 20-22hr  (758) embryo 22-24hr  (665) larva L1  (288) larva L2  (423) larva L3 12hr old  (525) larva L3 puffstage 1-2  (524) larva L3 puffstage 3-6  (814) larva L3 puffstage 7-9  (1087) white prepupae new  (1238) white prepupae 12hr  (583) white prepupae 24hr  (695) pupae 2d postWPP  (1511) pupae 3d postWPP  (3260) pupae 4d postWPP  (1365) adult male 01day  (3051) adult male 05day  (2160) adult male 30day  (1048) adult female 01day  (1741) adult female 05day  (902) adult female 30day  (679) Expression Level Scale  None   Extremely low   Very low   Low  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    841 embryo 02-04hr    622 embryo 04-06hr    197 embryo 06-08hr    270 embryo 08-10hr    521 embryo 10-12hr    540 embryo 12-14hr    885 embryo 14-16hr  (1611) embryo 16-18hr  (2484) embryo 18-20hr    1324 embryo 20-22hr    758 embryo 22-24hr    665 larva L1    288 larva L2    423 larva L3 12hr old    525 larva L3 puffstage 1-2    524 larva L3 puffstage 3-6    814 larva L3 puffstage 7-9    1087 white prepupae new    1238 white prepupae 12hr    583 white prepupae 24hr    695 pupae 2d postWPP  (1511) pupae 3d postWPP  (3260) pupae 4d postWPP    1365 adult male 01day  (3051) adult male 05day  (2160) adult male 30day    1048 adult female 01day  (1741) adult female 05day    902 adult female 30day    679 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    841 embryo 02-04hr    622 embryo 04-06hr    197 embryo 06-08hr    270 embryo 08-10hr    521 embryo 10-12hr    540 embryo 12-14hr    885 embryo 14-16hr    1611 embryo 16-18hr    2484 embryo 18-20hr    1324 embryo 20-22hr    758 embryo 22-24hr    665 larva L1    288 larva L2    423 larva L3 12hr old    525 larva L3 puffstage 1-2    524 larva L3 puffstage 3-6    814 larva L3 puffstage 7-9    1087 white prepupae new    1238 white prepupae 12hr    583 white prepupae 24hr    695 pupae 2d postWPP    1511 pupae 3d postWPP    3260 pupae 4d postWPP    1365 adult male 01day    3051 adult male 05day    2160 adult male 30day    1048 adult female 01day    1741 adult female 05day    902 adult female 30day    679 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    841 embryo 02-04hr    622 embryo 04-06hr    197 embryo 06-08hr    270 embryo 08-10hr    521 embryo 10-12hr    540 embryo 12-14hr    885 embryo 14-16hr    1611 embryo 16-18hr    2484 embryo 18-20hr    1324 embryo 20-22hr    758 embryo 22-24hr    665 larva L1    288 larva L2    423 larva L3 12hr old    525 larva L3 puffstage 1-2    524 larva L3 puffstage 3-6    814 larva L3 puffstage 7-9    1087 white prepupae new    1238 white prepupae 12hr    583 white prepupae 24hr    695 pupae 2d postWPP    1511 pupae 3d postWPP    3260 pupae 4d postWPP    1365 adult male 01day    3051 adult male 05day    2160 adult male 30day    1048 adult female 01day    1741 adult female 05day    902 adult female 30day    679 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  log, scaled to maximum FBgn0261259 expression level Developmental Stage   Expression Level embryo 00-02hr    841 embryo 02-04hr    622 embryo 04-06hr    197 embryo 06-08hr    270 embryo 08-10hr    521 embryo 10-12hr    540 embryo 12-14hr    885 embryo 14-16hr    1611 embryo 16-18hr    2484 embryo 18-20hr    1324 embryo 20-22hr    758 embryo 22-24hr    665 larva L1    288 larva L2    423 larva L3 12hr old    525 larva L3 puffstage 1-2    524 larva L3 puffstage 3-6    814 larva L3 puffstage 7-9    1087 white prepupae new    1238 white prepupae 12hr    583 white prepupae 24hr    695 pupae 2d postWPP    1511 pupae 3d postWPP    3260 pupae 4d postWPP    1365 adult male 01day    3051 adult male 05day    2160 adult male 30day    1048 adult female 01day    1741 adult female 05day    902 adult female 30day    679 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High  log, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (841) embryo 02-04hr  (622) embryo 04-06hr  (197) embryo 06-08hr  (270) embryo 08-10hr  (521) embryo 10-12hr  (540) embryo 12-14hr  (885) embryo 14-16hr  (1611) embryo 16-18hr  (2484) embryo 18-20hr  (1324) embryo 20-22hr  (758) embryo 22-24hr  (665) larva L1  (288) larva L2  (423) larva L3 12hr old  (525) larva L3 puffstage 1-2  (524) larva L3 puffstage 3-6  (814) larva L3 puffstage 7-9  (1087) white prepupae new  (1238) white prepupae 12hr  (583) white prepupae 24hr  (695) pupae 2d postWPP  (1511) pupae 3d postWPP  (3260) pupae 4d postWPP  (1365) adult male 01day  (3051) adult male 05day  (2160) adult male 30day  (1048) adult female 01day  (1741) adult female 05day  (902) adult female 30day  (679) Expression Level Scale  None   Extremely low   Very low   Low  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    841 embryo 02-04hr    622 embryo 04-06hr    197 embryo 06-08hr    270 embryo 08-10hr    521 embryo 10-12hr    540 embryo 12-14hr    885 embryo 14-16hr  1611 embryo 16-18hr  (2484) embryo 18-20hr    1324 embryo 20-22hr    758 embryo 22-24hr    665 larva L1    288 larva L2    423 larva L3 12hr old    525 larva L3 puffstage 1-2    524 larva L3 puffstage 3-6    814 larva L3 puffstage 7-9    1087 white prepupae new    1238 white prepupae 12hr    583 white prepupae 24hr    695 pupae 2d postWPP  1511 pupae 3d postWPP  (3260) pupae 4d postWPP    1365 adult male 01day  (3051) adult male 05day  2160 adult male 30day    1048 adult female 01day  1741 adult female 05day    902 adult female 30day    679 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    841 embryo 02-04hr    622 embryo 04-06hr    197 embryo 06-08hr    270 embryo 08-10hr    521 embryo 10-12hr    540 embryo 12-14hr    885 embryo 14-16hr    1611 embryo 16-18hr    2484 embryo 18-20hr    1324 embryo 20-22hr    758 embryo 22-24hr    665 larva L1    288 larva L2    423 larva L3 12hr old    525 larva L3 puffstage 1-2    524 larva L3 puffstage 3-6    814 larva L3 puffstage 7-9    1087 white prepupae new    1238 white prepupae 12hr    583 white prepupae 24hr    695 pupae 2d postWPP    1511 pupae 3d postWPP    3260 pupae 4d postWPP    1365 adult male 01day    3051 adult male 05day    2160 adult male 30day    1048 adult female 01day    1741 adult female 05day    902 adult female 30day    679 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    841 embryo 02-04hr    622 embryo 04-06hr    197 embryo 06-08hr    270 embryo 08-10hr    521 embryo 10-12hr    540 embryo 12-14hr    885 embryo 14-16hr    1611 embryo 16-18hr    2484 embryo 18-20hr    1324 embryo 20-22hr    758 embryo 22-24hr    665 larva L1    288 larva L2    423 larva L3 12hr old    525 larva L3 puffstage 1-2    524 larva L3 puffstage 3-6    814 larva L3 puffstage 7-9    1087 white prepupae new    1238 white prepupae 12hr    583 white prepupae 24hr    695 pupae 2d postWPP    1511 pupae 3d postWPP    3260 pupae 4d postWPP    1365 adult male 01day    3051 adult male 05day    2160 adult male 30day    1048 adult female 01day    1741 adult female 05day    902 adult female 30day    679 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     FlyAtlas Anatomical Expression Data for FBgn0261259    Styles Linear Logarithmic Heatmap Back-to-back    Scales max expr for FBgn0261259 Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Two or more Affy2 ProbeSets identify exons of this gene. This is a summary of the tissue expression peaks exhibited in at least one of these ProbeSets. Expression at high levels in the following post-embryonic organs or tissues: adult carcass. Expression at moderate levels in the following post-embryonic organs or tissues: adult eye, adult crop, adult midgut, larval/adult hindgut, larval Malpighian tubules, larval/adult salivary gland, adult male accessory gland, larval carcass. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (1000 - 25000) Heatmap Tissue   Expression Level Larval Central Nervous System no informative data Larval Midgut no informative data Larval Hindgut no informative data Larval Malpighian Tubules no informative data Larval Fat Body no informative data Larval Salivary Gland no informative data Larval Trachea no informative data Larval Carcass no informative data Adult Head no informative data Adult Eye no informative data Adult Brain no informative data Adult Thoracic-Abdominal Ganglion no informative data Adult Crop no informative data Adult Midgut no informative data Adult Hindgut no informative data Adult Malpighian Tubules no informative data Adult Fat Body     Adult Salivary Gland no informative data Adult Heart no informative data Adult VirginFemale Spermatheca no informative data Adult InseminatedFemale Spermatheca no informative data Adult Ovary no informative data Adult Testis     Adult Male Accessory Gland no informative data Adult Carcass no informative data modENCODE Temporal Expression Data (Graveley et al., 2011) FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
Expression Clusters
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0261259
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele semi-lethal | pupal stage, with Scer\GAL4pnr-MD237 FhosGD2374 viable FhosEY09842 viable, with Scer\GAL4pnr-MD237 FhosGD10435 Sterility Allele fertile FhosEY09842 Other Phenotypes Allele stress response defective FhosBG01659 Phenotype manifest in Allele
Classical Alleles ( 25 )
For All Classical Alleles Show
Allele of Fhos Class Mutagen Stocks Known lesion FhosA055 1 -- Fhosc01816 1 -- FhosCB-0081-3 1 -- FhosCB-5690-3 1 -- Fhosd11743 P-element activity 1 -- Fhose00447 piggyBac transposase 1 -- Fhose01740 piggyBac transposase 1 -- FhosEY09842 P-element activity 1 -- Fhosf00682 piggyBac transposase 1 -- Fhosf01071 piggyBac transposase 1 -- Fhosf01857 piggyBac transposase 1 -- Fhosf06237 piggyBac transposase 1 -- FhosKG05956 1 -- FhosMI01421 1 -- FhosNP5482 1 -- FhosBG01659 0 Yes Fhosd01779 0 -- Fhosd05648 P-element activity 0 -- Fhosd10071 P-element activity 0 -- Fhosd11508 P-element activity 0 -- Fhose01756 piggyBac transposase 0 -- Fhosf01953 piggyBac transposase 0 -- Fhosf02813 piggyBac transposase 0 -- Fhosf03047 piggyBac transposase 0 -- Fhosf06945 piggyBac transposase 0 --
Alleles Carried on Transgenic Constructs ( 4 )
For All Alleles Carried on Transgenic Constructs Show
Allele of Fhos Class Mutagen Stocks Known lesion FhosGD2374 in vitro construct - RNAi in vitro construct - regulatory fusion 5 Yes FhosGD10435 in vitro construct - RNAi in vitro construct - regulatory fusion 2 Yes FhosJF01606 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes FhosKK108388 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes
Aneuploid Aberrations
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD10435} NA P{KK108388} NA P{TRiP.JF01606} NA
Insertions
	Type of insertions Name Expression data insertion of mobile activating element P{EPgy2}FhosEY09842 NA P{XP}Fhosd01779 NA P{XP}Fhosd05648 NA P{XP}Fhosd10071 NA P{XP}Fhosd11508 NA P{XP}Fhosd11743 NA miscellaneous insertions Mi{MIC}FhosMI01421 NA P{GT1}FhosBG01659 NA P{RS3}FhosCB-0081-3 NA P{RS3}FhosCB-5690-3 NA P{SUPor-P}FhosKG05956 NA P{UASp-YFP.Rab23.Q96L}04 NA PBac{5HPw+}FhosA055 NA PBac{PB}Fhosc01816 NA PBac{RB}Fhose00447 NA PBac{RB}Fhose01740 NA PBac{RB}Fhose01756 NA PBac{WH}Fhosf00682 NA PBac{WH}Fhosf01071 NA PBac{WH}Fhosf01857 NA PBac{WH}Fhosf01953 NA PBac{WH}Fhosf02813 NA PBac{WH}Fhosf03047 NA PBac{WH}Fhosf06237 NA PBac{WH}Fhosf06945 NA insertion of enhancer trap binary system P{GawB}FhosNP5482 No
Gene Ontology: Function, Process & Cellular Component ( 2 unique terms )
Terms Based on Experimental Evidence ( 0 terms )
Terms Based on Predictions or Assertions ( 2 terms )
Molecular Function
CV term Evidence References
actin binding inferred from electronic annotation with InterPro:IPR003104 (FlyBase Curators et al., 2004-) inferred from sequence or structural similarity (Goldstein and Gunawardena, 2000)
Biological Process
CV term Evidence References
actin cytoskeleton organization inferred from electronic annotation with InterPro:IPR003104 (FlyBase Curators et al., 2004-)
Cellular Component ( 0 terms)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Protein-protein
Interacting group Assay References
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions Fhos allele Gene References
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 64410 DroID - A comprehensive database of gene and protein interactions. • FBgn0261259 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 39004
Orthologs
Genome-wide drosophilid orthologs	Dana\GF24353 Dana\GF24355 Dere\GG14347 Dere\GG14348 Dgri\GH15327 Dgri\GH15328 Dmoj\GI12928 Dmoj\GI12929 Dper\GL10340 Dper\GL10342 Dpse\GA16619 Dpse\GA16623 Dsec\GM25090 Dsec\GM25091 Dsim\GD14126 Dsim\GD14127 Dvir\GJ13072 Dvir\GJ13073 Dwil\GK16737 Dwil\GK16738 Dyak\GE20777 Dyak\GE20778
Curated drosophilid orthologs	Dpse\GA16619   Dpse\GA16623
Linkouts	OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • PB18887 NV50438 LH21831 ISCW016448 FBgn0238077 FBgn0218738 FBgn0200301 FBgn0185817 FBgn0179952 JGI_V11_198277 FBgn0076638 FBgn0147952 FBgn0135686 FBgn0122800 FBgn0121372 FBgn0106609 FBgn0101349 CPIJ006609 BGIBMGA000615 ACYPI000709 GB13180 AGAP004873 AAEL010187 PHUM581370 GLEAN_03980
Stocks & Reagents
Stocks Listed in FlyBase ( 24 )
Harvard	- P{XP}Fhosd11743 - PBac{PB}Fhosc01816 - PBac{RB}Fhose00447 - PBac{RB}Fhose01740 - PBac{WH}Fhosf00682 - PBac{WH}Fhosf01071 - PBac{WH}Fhosf01857 - PBac{WH}Fhosf06237
VDRC	v108347 P{KK108388}VIE-260B v13298 w1118 P{GD2374}v13298 v45836 w1118; P{GD2374}v45836 v45837 w1118; P{GD2374}v45837
	More stocks available...
Genomic Clones ( 2 )
	BACR18D24 BACR26I03 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 61 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	LD24110 SD08909
Other clones	FI03664 IP17223 MIP14754
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	LD20269 LD25163 LD32443 LP09862 RE36256 RE37245 RE67937 RE68336 SD22203
Other clones	18071 156092 190036 214257.71 277319 CK01.93C.C10 EC251469 EK003335 EK019017 EK021340 EK065851 EK070636 EK073041 EK092221 EK097062 EK097310 EK100701 EK135319 EK141243 EK155427 EK157457 EK166510 EK171560 EK198410 EK204842 EK219010 EK247449 EK253930 EK258762 EK258939 EK291334 EK304155 EP04447 EP13304 EP15012 EP21654 IP10251 IP17323 IP17423 IP17523 LD23782 RP004233605 RP004239015 RP004240910 RP004243171 RP004245589 RP004549070
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0261259 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 39004 53441
Antibody Information
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of	Source for identity of: Fhos CG32030 (Montana and Littleton, 2006)
Source for database merge of	Source for merge of: CG5775 CG5797 (FlyBase Genome Annotators, 2002-2003) Source for merge of: Fhos desert (FlyBase Genome Annotators, 2009)
Additional comments	Annotations CG32025 and CG32030 merged as CG42610 in release 5.20 of the genome annotation. (FlyBase Genome Annotators, 2009) Annotations CG5775 and CG5797 merged as CG32030 in release 3 of the genome annotation. (FlyBase Genome Annotators, 2002-2003)
Other Comments
	dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R+ cell morphology. (Kiger et al., 2003) New annotation (CG32025) in release 3 of the genome annotation. (FlyBase Genome Annotators, 2002-2003)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_168293 NM_168294 NM_001169916 NM_001202142 NM_001202143 RefSeq (Proteins) • NP_729410 NP_729411 NP_001163387 NP_001189071 NP_001189072 DDBJ / EMBL / GenBank • AA817618 AAF34753 AAF50365 AAF50366 AAL68224 AAL89950 ACZ94658 ADV37508 ADV37509 AF217845 AI455425 AI542550 AW944574 AY075386 AY084212 CL526154 CZ474646 CZ477086 CZ477087 CZ477773 CZ477774 CZ477891 CZ478335 CZ479551 CZ479552 CZ479570 CZ483146 CZ483559 CZ483560 CZ484350 CZ484351 CZ484455 CZ484456 CZ485363 CZ485364 CZ485603 CZ488903 CZ488904 CZ489685 CZ489686 Entrez Gene - A searchable database of RefSeq genes. • 39004 UniProtKB/TrEMBL • E1JI78 Q8SY43 Q8T4F5 Q9NHX5 Q9VSQ0 Q9VSQ1
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Actin-binding FH2/DRF autoregulatory (IPR003104) GTPase-binding/formin homology 3 (IPR014768) Actin-binding FH2 (IPR015425) Diaphanous autoregulatory (IPR014767) Armadillo-type fold (IPR016024)
Linkouts
	BioGRID - A database of protein and genetic interactions • 64410 DroID - A comprehensive database of gene and protein interactions. • FBgn0261259 DRSC - Results from RNAi screens. • FBgn0261259 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0261259 FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0261259 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 39004 53441 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 39004 modMine - Data generated by the modENCODE project. • FBgn0261259 OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • PB18887 NV50438 LH21831 ISCW016448 FBgn0238077 FBgn0218738 FBgn0200301 FBgn0185817 FBgn0179952 JGI_V11_198277 FBgn0076638 FBgn0147952 FBgn0135686 FBgn0122800 FBgn0121372 FBgn0106609 FBgn0101349 CPIJ006609 BGIBMGA000615 ACYPI000709 GB13180 AGAP004873 AAEL010187 PHUM581370 GLEAN_03980
Synonyms & Secondary IDs ( 8 )
Reported As
Symbol Synonym	CG5775 (Montana and Littleton, 2006, Lai et al., 2007) CG5797 (Tanaka et al., 2004, Huntley and Golding, 2004, Boutros et al., 2002, Goldstein and Gunawardena, 2000, Montana and Littleton, 2006) CG32025   CG32030 (Girard et al., 2006, Zhang et al., 2007, Bakal et al., 2007, Lipatov et al., 2005, Keleman et al., 2009.8.5, Kim et al., 2005, Firth and Baker, 2007, Ni et al., 2008, Cammarato et al., 2011, Johansson et al., 2005) CG42610 (FlyBase Genome Annotators, 2009) desert (Zhang et al., 2007) dFHOS (Montana and Littleton, 2006) Fhos (Kucherenko et al., 2008, Wasbrough et al., 2010, Watson et al., 2011)
Name Synonym	CG32030   desert   Fhos
Secondary FlyBase IDs
	FBgn0035925 FBgn0035927 FBgn0040229 FBgn0052025 FBgn0052030
References ( 39 )
Generate a list of	All references relating to this gene ( 39 )
List References by type	Research paper  ( 17 ) Supplementary material  ( 8 ) Personal communication to FlyBase  ( 5 ) FlyBase analysis  ( 4 ) DNA/RNA sequence record  ( 1 ) Computer file  ( 3 ) Automatic genome annotation  ( 1 )
Recent research papers ( 2 )
	Kucherenko et al., 2011, Dev. Biol. 352(2): 228--242 Stress and muscular dystrophy: a genetic screen for dystroglycan and dystrophin interactors in Drosophila identifies cellular stress response components. [FBrf0214383] Watson et al., 2011, Development 138(7): 1285--1295 Drosophila hedgehog signaling and engrailed-runt mutual repression direct midline glia to alternative ensheathing and non-ensheathing fates. [FBrf0213237] Show all research papers ...