MitoPLD
nuclease that functions in germline RNAi processes, required in dorso-ventral patterning pathway - required early during oogenesis for the translational silencing of mRNA and at later stages for proper expression of the Grk protein - regulates telomere-specific transposable elements
Please see the GBrowse view of Dmel\zuc or the JBrowse view of Dmel\zuc for information on other features
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Gene model reviewed during 5.51
There is only one protein coding transcript and one polypeptide associated with this gene
Homodimer (By similarity). Interacts with miga/CG12125 (PubMed:26711011).
In contrast to other members of the phospholipase D family, contains only one PLD phosphodiesterase domain, suggesting that it has a single half-catalytic and requires homodimerization to form a complete active site.
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\zuc using the Feature Mapper tool.
Comment: maternally deposited
GBrowse - Visual display of RNA-Seq signals
View Dmel\zuc in GBrowse 22-45
Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
Source for merge of: zuc CG12314
zuc is required for rasiRNA production in the female germline.
Mutations at the zuc locus cause defects in midoogenesis.
