FlyBase Gene Report: Dmel\zuc

General Information

Symbol

Dmel\zuc

Species

D. melanogaster

Name

zucchini

Annotation Symbol

CG12314

Feature Type

protein_coding_gene

FlyBase ID

FBgn0261266

Gene Model Status

Stock Availability

9 publicly available

Gene Summary

zucchini (zuc) encodes a member of the phospholipase D superfamily. It is anchored in the outer mitochondrial membrane and functions in the processing of primary piRNA transcripts through its endonuclease activity. zuc depletion causes sterility, transposon de-repression and accumulation of piRNA cluster transcripts. [Date last reviewed: 2019-03-21] (FlyBase Gene Snapshot)

All Summaries

Gene Snapshot
Alliance
Auto summary
Gene Group
UniProtKB
Interactive Fly

Also Known As

MitoPLD

Key Links

Genomic Location

Cytogenetic map

Sequence location

2L:11,988,735..11,989,882 [-]

Recombination map

2-45

RefSeq locus

NT_033779 REGION:11988735..11989882

Sequence

Get Decorated FASTA

Genomic Maps

JBrowse GBrowse

Other Genome Views

The following external sites may use different assemblies or annotations than FlyBase.

Function

GO Summary Ribbons

Gene Ontology (GO) Annotations (11 terms)

Molecular Function (2 terms)

Terms Based on Experimental Evidence (2 terms)

CV Term

Evidence

References

enables cardiolipin hydrolase activity

inferred from direct assay

(assigned by UniProt )

(Huang et al., 2011)

enables endoribonuclease activity, producing 5'-phosphomonoesters

inferred from direct assay

(Nishimasu et al., 2012)

Terms Based on Predictions or Assertions (1 term)

CV Term

Evidence

References

enables endoribonuclease activity, producing 5'-phosphomonoesters

inferred from biological aspect of ancestor with PANTHER:PTN000478646

(assigned by GO_Central )

(Gaudet et al., 2011)

Biological Process (7 terms)

Terms Based on Experimental Evidence (7 terms)

CV Term

Evidence

References

involved_in dorsal appendage formation

inferred from high throughput mutant phenotype

(Schupbach and Wieschaus, 1991)

involved_in gene silencing by RNA

inferred from mutant phenotype

(Pane et al., 2007)

involved_in oocyte karyosome formation

inferred from mutant phenotype

(Ghabrial et al., 1998)

involved_in oogenesis

inferred from high throughput mutant phenotype

(Schupbach and Wieschaus, 1991)

involved_in piRNA biosynthetic process

inferred from mutant phenotype

(Yamashiro et al., 2020, Akkouche et al., 2017)

involved_in piRNA metabolic process

inferred from mutant phenotype

(assigned by UniProt )

(Saito et al., 2010)

inferred from mutant phenotype

(Nishimasu et al., 2012)

involved_in RNA phosphodiester bond hydrolysis, endonucleolytic

inferred from direct assay

(Nishimasu et al., 2012)

Terms Based on Predictions or Assertions (2 terms)

CV Term

Evidence

References

involved_in oogenesis

traceable author statement

(van Eeden and St. Johnston, 1999)

involved_in piRNA metabolic process

inferred from biological aspect of ancestor with PANTHER:PTN000478647

(assigned by GO_Central )

(Gaudet et al., 2011)

Cellular Component (2 terms)

Terms Based on Experimental Evidence (2 terms)

CV Term

Evidence

References

is_active_in mitochondrion

inferred from direct assay

(Ge et al., 2019)

located_in mitochondrion

inferred from direct assay

(assigned by UniProt )

(Saito et al., 2010)

inferred from direct assay

(Huang et al., 2011)

located_in P granule

inferred from direct assay

(Pane et al., 2007)

NOT located_in P granule

inferred from direct assay

(assigned by UniProt )

(Huang et al., 2011, Saito et al., 2010)

Terms Based on Predictions or Assertions (1 term)

CV Term

Evidence

References

is_active_in mitochondrion

inferred from biological aspect of ancestor with PANTHER:PTN000478647

(assigned by GO_Central )

(Gaudet et al., 2011)

Gene Group (FlyBase)

OTHER PHOSPHORIC DIESTER HYDROLASES

OTHER ENDORIBONUCLEASES

Protein Family (UniProt)

Belongs to the phospholipase D family. MitoPLD/Zucchini subfamily. (Q9VKD7)

Protein Signatures (InterPro)

Phospholipase D-like domain

Summaries

Gene Snapshot

zucchini (zuc) encodes a member of the phospholipase D superfamily. It is anchored in the outer mitochondrial membrane and functions in the processing of primary piRNA transcripts through its endonuclease activity. zuc depletion causes sterility, transposon de-repression and accumulation of piRNA cluster transcripts. [Date last reviewed: 2019-03-21]

Gene Group (FlyBase)

OTHER PHOSPHORIC DIESTER HYDROLASES -: Other phosphoric diester hydrolases are a collection of hydrolases that do not fall into any other major phosphoric diester hydrolases.
OTHER ENDORIBONUCLEASES -: Other endoribonucleases are a collection of endonucleases that do not fall into any of the major endoribonucleases.

Protein Function (UniProtKB)

Cardiolipin hydrolase present at the mitochondrial outer membrane required for piRNA metabolic process. Acts by catalyzing the hydrolysis of cardiolipin (diphosphatidylglycerol) to form phosphatidate (phosphatidic acid or PA) at the mitochondrial outer membrane surface, promoting the piRNA metabolic process. Plays a key role in primary biogenesis of piRNAs and is required during oogenesis to repress transposable elements and prevent their mobilization. piRNAs mediate the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and govern the methylation and subsequent repression of transposons. Involved in trans-silencing effect (TSE), a homology-dependent repression mechanism by which a P-transgene inserted in subtelomeric heterochromatin via its role in piRNA biogenesis.

(UniProt, Q9VKD7)

Summary (Interactive Fly)

nuclease that functions in germline RNAi processes, required in dorso-ventral patterning pathway - required early during oogenesis for the translational silencing of mRNA and at later stages for proper expression of the Grk protein - regulates telomere-specific transposable elements

Interactive Fly

Gene Model and Products

Number of Transcripts

1

Number of Unique Polypeptides

1

Please see the JBrowse view of Dmel\zuc for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)

Isoform displayed:

Pfam protein domains

InterPro name

classification

start

end

Protein Domains (via SMART)

Isoform displayed:

SMART protein domains

InterPro name

classification

start

end

Comments on Gene Model

Gene model reviewed during 5.51

Sequence Ontology: Class of Gene

protein_coding_gene

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Assoc. CDS (aa)

FBtr0080316

1148

253

Additional Transcript Data and Comments

Reported size (kB)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kDa)

Length (aa)

Theoretical pI

RefSeq ID

GenBank

FBpp0079900

28.5

253

9.53

Polypeptides with Identical Sequences

There is only one protein coding transcript and one polypeptide associated with this gene

Additional Polypeptide Data and Comments

Reported size (kDa)

Comments

External Data

Subunit Structure (UniProtKB)

Homodimer (By similarity). Interacts with miga/CG12125 (PubMed:26711011).

(UniProt, Q9VKD7)

Domain

In contrast to other members of the phospholipase D family, contains only one PLD phosphodiesterase domain, suggesting that it has a single half-catalytic and requires homodimerization to form a complete active site.

(UniProt, Q9VKD7)

Crossreferences

InterPro - A database of protein families, domains and functional sites

Phospholipase D-like domain

Linkouts

Sequences Consistent with the Gene Model

Nucleotide / Polypeptide Records

Q9VKD7

Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\zuc using the Feature Mapper tool.

External Data

Crossreferences

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

zuc_1

Linkouts

Expression Data

Expression Summary Ribbons

Colored tiles in ribbon indicate that expression data has been curated by FlyBase for that anatomical location. Colorless tiles indicate that there is no curated data for that location.

For complete stage-specific expression data, view the modENCODE Development RNA-Seq section under High-Throughput Expression below.

Transcript Expression

in situ

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage 1 -- 3

Comment: maternally deposited

(Fisher et al., 2012)

embryonic stage 4 -- 6

organism | ubiquitous

(Fisher et al., 2012)

embryonic stage 7 -- 8

anterior endoderm anlage

(Fisher et al., 2012)

(Fisher et al., 2012)

organism | faint | ubiquitous

(Fisher et al., 2012)

posterior endoderm

(Fisher et al., 2012)

(Fisher et al., 2012)

embryonic stage 9 -- 10

anterior endoderm

(Fisher et al., 2012)

(Fisher et al., 2012)

organism | faint | ubiquitous

(Fisher et al., 2012)

posterior endoderm

(Fisher et al., 2012)

(Fisher et al., 2012)

embryonic stage 11 -- 12

anterior midgut primordium

(Fisher et al., 2012)

(Fisher et al., 2012)

posterior midgut primordium

(Fisher et al., 2012)

(Fisher et al., 2012)

embryonic stage 13 -- 16

embryonic/larval midgut

(Fisher et al., 2012)

embryonic/larval visceral muscle cell

(Fisher et al., 2012)

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Polypeptide Expression

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Evidence

References

is_active_in mitochondrion

inferred from direct assay

(Ge et al., 2019)

located_in mitochondrion

inferred from direct assay

(assigned by UniProt )

(Saito et al., 2010)

inferred from direct assay

(Huang et al., 2011)

located_in P granule

inferred from direct assay

(Pane et al., 2007)

NOT located_in P granule

inferred from direct assay

(assigned by UniProt )

(Huang et al., 2011, Saito et al., 2010)

Expression Deduced from Reporters

High-Throughput Expression Data

Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\zuc in GBrowse 2

RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region

View exonic expression by developmental stage for Dmel\zuc

View exonic expression by tissue for Dmel\zuc

Bulk Downloads

RNA-Seq RPKM values for all genes

Reference

See Gelbart and Emmert, 2013 for analysis details and data files for all genes.

Developmental Proteome: Life Cycle

Developmental Proteome: Embryogenesis

External Data and Images

Linkouts

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0261266

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

34609/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0261266

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0032389

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0261266

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG12314

Flygut - An atlas of the Drosophila adult midgut

FBgn0261266

Images

Image Based Resources

Alleles, Insertions, Transgenic Constructs, and Aberrations

Classical and Insertion Alleles ( 8 )

For All Classical and Insertion Alleles Show

Other relevant insertions

Transgenic Constructs ( 16 )

For All Alleles Carried on Transgenic Constructs Show

Transgenic constructs containing/affecting coding region of zuc

Transgenic constructs containing regulatory region of zuc

Aberrations (Deficiencies and Duplications) ( 3 )

Inferred from experimentation ( 3 )

Gene disrupted in

(Ryder, 2004.4.26)

(Schupbach and Wieschaus, 1991)

(Chen et al., 2021, Schupbach and Wieschaus, 1991)

Inferred from location ( 0 )

Alleles Representing Disease-Implicated Variants

Phenotypes

For more details about a specific phenotype click on the relevant allele symbol.

Lethality

Allele

viable, with Dcr-2^UAS.cDa, Scer\GAL4^elav.PLu

zuc^GD6746

viable, with Scer\GAL4^tin.CΔ4

zuc^GD6746

Sterility

Allele

female sterile, with Scer\GAL4^nos.PG

Other Phenotypes

Allele

abnormal size | third instar larval stage, with Scer\GAL4^Cg.PA

zuc^HMS03002

Phenotype manifest in

Allele

dorsal appendage

zuc^RS49

dorsal appendage (with Df(2L)Prl)

zuc^RS49

egg (with Df(2L)Prl)

zuc^unspecified

embryonic/larval fat body | third instar larval stage, with Scer\GAL4^Cg.PA

zuc^HMS03002

zuc^unspecified

mitochondrion, with Scer\GAL4^Cg.PA

zuc^{DN.UAS.Tag:HA}

mitochondrion | third instar larval stage, with Scer\GAL4^Cg.PA

zuc^HMS03002

zuc^unspecified

Orthologs

Downloads

Download All DIOPT Orthologs

Download All OrthoDB Orthologs

Human Orthologs (via DIOPT v8.0)

Homo sapiens (Human) (4)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

12 of 15

Yes

Yes

1 of 15

No

No

1 of 15

No

No

1

1 of 15

No

No

3

Model Organism Orthologs (via DIOPT v8.0)

Mus musculus (laboratory mouse) (4)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

10 of 15

Yes

Yes

1 of 15

No

No

1 of 15

No

No

1 of 15

No

No

Rattus norvegicus (Norway rat) (4)

11 of 13

Yes

Yes

1 of 13

No

No

1 of 13

No

No

1 of 13

No

No

Xenopus tropicalis (Western clawed frog) (4)

11 of 12

Yes

Yes

1 of 12

No

No

1 of 12

No

No

1 of 12

No

No

Danio rerio (Zebrafish) (6)

11 of 15

Yes

Yes

1 of 15

No

No

1 of 15

No

No

1 of 15

No

No

1 of 15

No

No

Drer\si:ch211-168k14.2

1 of 15

No

No

Caenorhabditis elegans (Nematode, roundworm) (2)

1 of 15

Yes

No

1 of 15

Yes

No

Arabidopsis thaliana (thale-cress) (0)

No records found.

Saccharomyces cerevisiae (Brewer's yeast) (2)

1 of 15

Yes

No

1 of 15

Yes

No

Schizosaccharomyces pombe (Fission yeast) (0)

No records found.

Ortholog(s) in Drosophila Species (via OrthoDB v9.1) ( EOG09190E73 )

Organism

Common Name

Gene

AAA Syntenic Ortholog

Multiple Dmel Genes in this Orthologous Group

Drosophila suzukii

Spotted wing Drosophila

Dsuz\DS10_00001973

Drosophila simulans

Drosophila sechellia

Drosophila erecta

Drosophila yakuba

Drosophila ananassae

Drosophila pseudoobscura pseudoobscura

Drosophila persimilis

Drosophila willistoni

Drosophila virilis

Drosophila mojavensis

Drosophila grimshawi

Orthologs in non-Drosophila Dipterans (via OrthoDB v9.1) ( EOG09150922 )

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Musca domestica

House fly

Lucilia cuprina

Australian sheep blowfly

Lcup\FF38_06549

Lucilia cuprina

Australian sheep blowfly

Lcup\FF38_06540

Lucilia cuprina

Australian sheep blowfly

Lcup\FF38_06544

Mayetiola destructor

Hessian fly

Mdes\Mdes003414

Aedes aegypti

Yellow fever mosquito

Aaeg\AAEL011385

Anopheles darlingi

American malaria mosquito

Adar\ADAC007150

Anopheles gambiae

Malaria mosquito

Agam\AGAP006233

Culex quinquefasciatus

Southern house mosquito

Cqui\CPIJ009798

Orthologs in non-Dipteran Insects (via OrthoDB v9.1) ( EOG090W0AGM )

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Bombyx mori

Silkmoth

Bmor\BGIBMGA007918

Danaus plexippus

Monarch butterfly

Dple\DPOGS213160-PA

Danaus plexippus

Monarch butterfly

Dple\DPOGS212319-PA

Heliconius melpomene

Postman butterfly

Hmel\HMEL009406

Apis florea

Little honeybee

Aflo\2478936036

Apis mellifera

Western honey bee

Bombus impatiens

Common eastern bumble bee

Linepithema humile

Argentine ant

Nasonia vitripennis

Parasitic wasp

Nvit\Nasvi2EG004552

Dendroctonus ponderosae

Mountain pine beetle

Tribolium castaneum

Red flour beetle

Tribolium castaneum

Red flour beetle

Pediculus humanus

Human body louse

Phum\PHUM318600

Rhodnius prolixus

Kissing bug

Rpro\RPRC014340

Rhodnius prolixus

Kissing bug

Rpro\RPRC012276

Rhodnius prolixus

Kissing bug

Rpro\RPRC005186

Cimex lectularius

Bed bug

Clec\CLEC003223

Cimex lectularius

Bed bug

Clec\CLEC007501

Acyrthosiphon pisum

Pea aphid

Apim\ACYPI47236

Zootermopsis nevadensis

Nevada dampwood termite

Znev\Znev_15027

Orthologs in non-Insect Arthropods (via OrthoDB v9.1) ( EOG090X09V1 )

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Strigamia maritima

European centipede

Smar\SMAR014632

Ixodes scapularis

Black-legged tick

Isca\ISCW009492

Stegodyphus mimosarum

African social velvet spider

Smim\KFM74166.1

Daphnia pulex

Water flea

Dpux\DAPPUDRAFT_331332

Daphnia pulex

Water flea

Dpux\DAPPUDRAFT_64062

Daphnia pulex

Water flea

Dpux\DAPPUDRAFT_308957

Orthologs in non-Arthropod Metazoa (via OrthoDB v9.1) ( EOG091G0FI5 )

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Strongylocentrotus purpuratus

Purple sea urchin

Spur\SPU_012787gn

Strongylocentrotus purpuratus

Purple sea urchin

Spur\SPU_021981gn

Ciona intestinalis

Vase tunicate

Cint\LOC100176787

Paralogs

Downloads

Download All DIOPT Paralogs

Paralogs (via DIOPT v8.0)

Drosophila melanogaster (Fruit fly) (2)

Gene Symbol

Score

Source

Alignment

1 of 10

1 of 10

Human Disease Associations

FlyBase Human Disease Model Reports

Disease Model Summary Ribbon

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Allele

Disease

Evidence

References

Potential Models Based on Orthology ( 0 )

Human Ortholog

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Allele

Disease

Interaction

References

Disease Associations of Human Orthologs (via DIOPT v8.0 and OMIM)

Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.

Homo sapiens (Human)

Gene name

Score

OMIM

OMIM Phenotype

DO term

Complementation?

Transgene?

PLD6; phospholipase D family member 6

12 of 15

Functional Complementation Data

Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.

Interactions

Summary of Physical Interactions

esyN Network Diagram

Interactions Browser

View in Interactions Browser

Please see the Physical Interaction reports below for full details

protein-protein

Physical Interaction

Assay

References

anti tag coimmunoprecipitation, anti tag western blot, protein cross-linking with a bifunctional reagent, confirmation by molecular weight

(Munafò et al., 2019, Zhang et al., 2016)

anti tag coimmunoprecipitation, western blot

(Huang et al., 2014)

anti tag coimmunoprecipitation, anti tag western blot

(Zhang et al., 2016)

anti tag coimmunoprecipitation, protein cross-linking with a bifunctional reagent, western blot, anti bait coimmunoprecipitation, anti tag western blot, Identification by mass spectrometry

(Ge et al., 2019, Ishizu et al., 2019)

anti tag coimmunoprecipitation, anti tag western blot

(Pane et al., 2007)

anti tag coimmunoprecipitation, anti tag western blot

(Haase et al., 2010)

Summary of Genetic Interactions

esyN Network Diagram

esyN Network Key:

Suppression

Enhancement

View in Interactions Browser

Please look at the allele data for full details of the genetic interactions

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

enhanceable

(Gell and Reenan, 2013)

External Data

Subunit Structure (UniProtKB)

Homodimer (By similarity). Interacts with miga/CG12125 (PubMed:26711011).

(UniProt, Q9VKD7 )

Linkouts

DroID - A comprehensive database of gene and protein interactions.

FBgn0261266

MIST (protein-protein) - An integrated Molecular Interaction Database

zuc

Pathways

Signaling Pathways (FlyBase)

Metabolic Pathways

FlyMet - A comprehensive tissue-specific metabolomics resource for Drosophila.

FBgn0261266

External Data

Linkouts

Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.

Synthesis of PA

Genomic Location and Detailed Mapping Data

Chromosome (arm)

2L

Recombination map

2-45

Cytogenetic map

Sequence location

2L:11,988,735..11,989,882 [-]

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

33B3-33F2

Left limit from inclusion within Df(2L)prd1.7 (FBrf0054123) Right limit from inclusion within Df(2L)Prl (FBrf0054123)

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

Experimentally Determined Recombination Data

Location

2-45

(FlyBase, 2016)

2-39.0

(Comeron et al., 2012)

2-[45]

Left of (cM)

Right of (cM)

Notes

Stocks and Reagents

Stocks (9)

18427

w¹¹¹⁸; PBac{WH}zuc^f01342

20310

y¹ w^67c23; P{EPgy2}zuc^EY11457

5120

zuc^RS49 cn¹ bw¹/CyO, l(2)DTS513¹

35227

y¹ sc^* v¹ sev²¹; P{TRiP.GL00111}attP2

35228

y¹ sc^* v¹ sev²¹; P{TRiP.GL00112}attP2

36742

y¹ sc^* v¹ sev²¹; P{TRiP.HMS03002}attP40

108052

zuc^RS49 cn¹ bw¹/CyO, l(2)DTS513¹

v110430

P{KK101658}VIE-260B

v48764

w¹¹¹⁸; P{GD6746}v48764/TM3

Genomic Clones (17)

Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

cDNA Clones (5)

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequenced

BDGP DGC clones

LD05365

Other clones

Drosophila Genomics Resource Center cDNA clones

For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

FBgn0261266

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

Other clones

CK01.1B.F8

RNAi and Array Information

Linkouts

DRSC - Results frm RNAi screens

FBgn0261266

GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents

34609

Antibody Information

Laboratory Generated Antibodies

polyclonal

(Haase et al., 2010)

Commercially Available Antibodies

Other Information

Relationship to Other Genes

Source for database identify of

Source for database merge of

Source for merge of: zuc CG12314

(Pane et al., 2007)

Additional comments

Other Comments

zuc is required for rasiRNA production in the female germline.

(Pane et al., 2007)

Mutations at the zuc locus cause defects in midoogenesis.

(Schupbach and Wieschaus, 1991)

Origin and Etymology

Discoverer

Etymology

Identification

External Crossreferences and Linkouts ( 34 )

Sequence Crossreferences

NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.

34609

GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.

GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.

RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.

UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information

Q9VKD7

Other crossreferences

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0261266

Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones

FBgn0261266

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

34609/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0261266

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

zuc_1

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0032389

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0261266

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG12314

Flygut - An atlas of the Drosophila adult midgut

FBgn0261266

FlyMet - A comprehensive tissue-specific metabolomics resource for Drosophila.

FBgn0261266

FlyMine - An integrated database for Drosophila genomics

FBgn0261266

GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents

34609

iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)

InterPro - A database of protein families, domains and functional sites

Phospholipase D-like domain

KEGG Genes - Molecular building blocks of life in the genomic space.

Dmel_CG12314

MARRVEL_MODEL - MARRVEL (model organism gene)

34609

modMine - A data warehouse for the modENCODE project

FBgn0261266

Linkouts

DroID - A comprehensive database of gene and protein interactions.

FBgn0261266

DRSC - Results frm RNAi screens

FBgn0261266

Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution

Interactive Fly

MIST (protein-protein) - An integrated Molecular Interaction Database

zuc

Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.

Synthesis of PA

Synonyms and Secondary IDs (8)

Reported As

Symbol Synonym

CG12314

(Ni et al., 2011.7.19, Keleman et al., 2009.8.5, Pane et al., 2007)

MitoPLD

(Xu et al., 2020, Zhang et al., 2016, Gupte, 2015, Muliyil and Narasimha, 2014, Muliyil et al., 2011)

ZUC

(Gamez et al., 2020, Kumar and Chen, 2012, Kolaczkowski et al., 2011)

zuc

(Chen et al., 2021, Ellison et al., 2020, Saint-Leandre et al., 2020, Ge et al., 2019, Kolliopoulou et al., 2019, Luhur et al., 2019, Wakisaka et al., 2019, Zhou et al., 2019, Kang et al., 2018, Ishizu et al., 2017, Rashpa et al., 2017, Blumenstiel et al., 2016, Fagegaltier et al., 2016, Ge et al., 2016, Kučerová et al., 2016, Zhang et al., 2016, Han et al., 2015, Hermant et al., 2015, Sienski et al., 2015, Yu et al., 2015, Huang et al., 2014, Lavrenov et al., 2014, Czech et al., 2013, Dennis et al., 2013, Gell and Reenan, 2013, Handler et al., 2013, Handler et al., 2013, Muerdter et al., 2013, Vagin et al., 2013, Olivieri et al., 2012, Vazquez-Pianzola and Suter, 2012, Handler et al., 2011, Klenov et al., 2011, Haase et al., 2010, Nagao et al., 2010, Olivieri et al., 2010, Saito et al., 2010, Todeschini et al., 2010, Malone et al., 2009, Robine et al., 2009, Saito et al., 2009, Chambeyron et al., 2008, Pane et al., 2007, Pane et al., 2007, Pane et al., 2007)

Name Synonyms

CG12314

Zucchini

(Cacchione et al., 2020, Sankaranarayanan and Weil, 2020, Thanh et al., 2020, Schmidt et al., 2019, Yamashiro and Siomi, 2018, Huang et al., 2017, Haase, 2016, Hayashi et al., 2016, Hirakata and Siomi, 2016, Castel and Martienssen, 2013, Mani and Juliano, 2013, Simkin et al., 2013, Nishimasu et al., 2012)

Zuchini

(Kelleher et al., 2020)

Secondary FlyBase IDs

FBgn0004056
FBgn0032389

Datasets (0)

Study focus (0)

Experimental Role

Project

Project Type

Title

References (135)

Report Sections