FB2025_01 , released February 20, 2025
Gene: Dmel\Sps1
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General Information
Symbol
Dmel\Sps1
Species
D. melanogaster
Name
Selenophosphate synthetase 1
Annotation Symbol
CG8553
Feature Type
protein_coding_gene
FlyBase ID
FBgn0261270
Gene Model Status
Current
Stock Availability
13 publicly available
Gene Summary
Selenophosphate synthetase 1 (Sps1) encodes a protein that inhibits Gs1 and dmGlut expression, which in turn regulates the intracellular levels of glutamine. [Date last reviewed: 2019-07-25] (FlyBase Gene Snapshot)
All Summaries
Also Known As

SelD, ptuf, patufet, selenide,water dikinase

Key Links
Genomic Location
Cytogenetic map
50E6-50E6
Sequence location
Recombination map
2-69
RefSeq locus
NT_033778 REGION:14268772..14270658
Sequence
Get Decorated FASTA
Genomic Maps
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
NCBI
UCSC
Ensembl
PopFly
Function
Gene Ontology (GO) Annotations (4 terms)
Molecular Function (2 terms)
Terms Based on Experimental Evidence (1 term)
CV Term
Evidence
References
NOT enables selenide, water dikinase activity
inferred from mutant phenotype
(Shim et al., 2009)
inferred from direct assay
(Persson et al., 1997)
Terms Based on Predictions or Assertions (2 terms)
CV Term
Evidence
References
enables ATP binding
inferred from electronic annotation with InterPro:IPR004536
(InterPro Project Members, 2004-)
NOT enables selenide, water dikinase activity
traceable author statement
(Hirosawa-Takamori et al., 2000)
Biological Process (1 term)
Terms Based on Experimental Evidence (1 term)
CV Term
Evidence
References
involved_in negative regulation of reactive oxygen species metabolic process
inferred from mutant phenotype
(Shim et al., 2009)
Terms Based on Predictions or Assertions (0 terms)
Cellular Component (1 term)
Terms Based on Experimental Evidence (0 terms)
Terms Based on Predictions or Assertions (1 term)
CV Term
Evidence
References
is_active_in cytoplasm
inferred from biological aspect of ancestor with PANTHER:PTN000029003
(GO Reference Genome Project, 2011-)
Gene Group (FlyBase)
Protein Family (UniProt)
Belongs to the selenophosphate synthase 1 family. Class II subfamily. (O18373)
Protein Signatures (InterPro)
Summaries
Gene Snapshot
Selenophosphate synthetase 1 (Sps1) encodes a protein that inhibits Gs1 and dmGlut expression, which in turn regulates the intracellular levels of glutamine. [Date last reviewed: 2019-07-25]
Gene Group (FlyBase)
UNCLASSIFIED PSEUDOKINASES -
This group comprises pseudokinases that do not classify under other groups in FlyBase.
Protein Function (UniProtKB)
Plays a role in apoptosis and consequently a role in imaginal disk patterning and growth.
(UniProt, O18373)
Gene Model and Products
Number of Transcripts
2
Number of Unique Polypeptides
1

Please see the JBrowse view of Dmel\Sps1 for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Structure
Protein 3D structure   (Predicted by AlphaFold)   (AlphaFold entry O18373)

If you don't see a structure in the viewer, refresh your browser.
Model Confidence:
  • Very high (pLDDT > 90)
  • Confident (90 > pLDDT > 70)
  • Low (70 > pLDDT > 50)
  • Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Experimentally Determined Structures
Crossreferences
Comments on Gene Model

Low-frequency RNA-Seq exon junction(s) not annotated.

Gene model reviewed during 5.50

Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
Sps1-RA
FBtr0087565
NM_166045
1521
398
Sps1-RB
FBtr0087564
NM_166046
1887
398
Additional Transcript Data and Comments
Reported size (kB)

1.6 (northern blot)

(Alsina et al., 1998)

1.539 (longest cDNA)

(Persson et al., 1997)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
UniProt
RefSeq ID
GenBank
Sps1-PA
FBpp0086691
43.4
398
6.93
O18373
NP_725374
AAF58266
Sps1-PB
FBpp0086690
43.4
398
6.93
O18373
NP_725375
AAM70998
Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

398 aa isoforms: Sps1-PA, Sps1-PB
Additional Polypeptide Data and Comments
Reported size (kDa)

398 (aa)

(Alsina et al., 1998, Persson et al., 1997)
Comments
External Data
Crossreferences
InterPro - A database of protein families, domains and functional sites
Linkouts
Sequences Consistent with the Gene Model
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Sps1 using the Feature Mapper tool.

External Data
Crossreferences
Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
Linkouts
Expression Data
Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

0.36

Transcript Expression
in situ
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage
organism | ubiquitous
(Persson et al., 1997)
embryonic stage 1 -- 3
organism

Comment: maternally deposited

(Fisher et al., 2012)
embryonic stage 4 -- 6
organism | ubiquitous
(Fisher et al., 2012)
embryonic stage 6 -- 17
midgut primordium
(Persson et al., 1997)
mesoderm
(Persson et al., 1997)
embryonic stage 7 -- 8
organism | ubiquitous
(Fisher et al., 2012)
embryonic stage 9 -- 10
organism | ubiquitous
(Fisher et al., 2012)
embryonic stage 11 -- 12
organism | ubiquitous
(Fisher et al., 2012)
embryonic stage 13 -- 16
organism | ubiquitous
(Fisher et al., 2012)
embryonic stage 13 -- 17
presumptive embryonic/larval central nervous system
(Persson et al., 1997)
embryonic/larval midgut
(Persson et al., 1997)
embryonic stage 14 -- 17
gastric caecum primordium
(Persson et al., 1997)
third instar larval stage
larval brain
(Alsina et al., 1999)
larval ventral nerve cord
(Alsina et al., 1999)
imaginal disc
(Alsina et al., 1999)
embryonic/larval optic lobe
(Alsina et al., 1999)
pupal stage
imaginal disc
(Alsina et al., 1999)
adult brain
(Alsina et al., 1999)
northern blot
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage -- adult stage
(Alsina et al., 1998)
third instar larval stage
imaginal disc
(Alsina et al., 1998)
Additional Descriptive Data

Sps1 expression is detected in imaginal discs and brains of third instar larvae and of pupae. Co-localization with BrdU indicates that expression is highest in dividing cells and low or undetectable in non-dividing cells.

(Alsina et al., 1999)

Sps1 transcript is expressed ubiquitously through embryogenesis and is enriched in the developing nervous system and midgut of the embryo.

(Persson et al., 1997)
Marker for
 
Subcellular Localization
CV Term
Polypeptide Expression
mass spectroscopy
Stage
Tissue/Position (including subcellular localization)
Reference
adult stage
adult head
(Aradska et al., 2015)
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Evidence
References
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\Sps1 in JBrowse
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Bulk Downloads
RNA-Seq RPKM values for all genes
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
Flygut - An atlas of the Drosophila adult midgut
Images
FlyBase Wiki
Image Based Resources
Alleles, Insertions, Transgenic Constructs, and Aberrations
Classical and Insertion Alleles ( 8 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 8 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of Sps1
Transgenic constructs containing regulatory region of Sps1
Aberrations (Deficiencies and Duplications) ( 3 )
Inferred from experimentation ( 3 )
Gene not disrupted in
Df(2R)CX1
(Spradling et al., 1999, BDGP Project Members, 1994-1999)
Gene disrupted in
Df(2R)Exel7131
(Ryder, 2004.4.26)
Gene partially disrupted in
Df(2R)convY58
(Swanson et al., 2009)
Inferred from location ( 5 )
Variants
Variant Molecular Consequences
Alleles Representing Disease-Implicated Variants
Phenotypes
Orthologs
Downloads
Download All DIOPT Orthologs
Human Orthologs (via DIOPT v9.1)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
Domainoid
eggNOG
Hieranoid
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Complementation?
Transgene?
Homo sapiens (Human) (2)
Hsap\SEPHS1
14 of 14
Yes
Yes
1  
Hsap\SEPHS2
13 of 14
No
Yes
Model Organism Orthologs (via DIOPT v9.1)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
Domainoid
eggNOG
Hieranoid
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Complementation?
Transgene?
Rattus norvegicus (Norway rat) (2)
Rnor\Sephs1
14 of 14
Yes
Yes
Rnor\Sephs2
1 of 14
No
Yes
Mus musculus (laboratory mouse) (2)
Mmus\Sephs1
13 of 14
Yes
Yes
Mmus\Sephs2
13 of 14
Yes
Yes
Xenopus tropicalis (Western clawed frog) (2)
Xtro\sephs1
11 of 13
Yes
Yes
Xtro\sephs3
4 of 13
No
Yes
Danio rerio (Zebrafish) (2)
Drer\sephs1
14 of 14
Yes
Yes
Drer\sephs3
10 of 14
No
Yes
Caenorhabditis elegans (Nematode, roundworm) (1)
Cele\seld-1
13 of 14
Yes
Yes
Anopheles gambiae (African malaria mosquito) (2)
Agam\AgaP_AGAP007967
12 of 12
Yes
Yes
Agam\AgaP_AGAP011375
7 of 12
No
No
Arabidopsis thaliana (thale-cress) (0)
Saccharomyces cerevisiae (Brewer's yeast) (0)
Schizosaccharomyces pombe (Fission yeast) (0)
Escherichia coli (enterobacterium) (2)
Ecol\selD
11 of 11
Yes
Yes
Ecol\purM
1 of 11
No
No
Other Organism Orthologs (via OrthoDB)
Data provided directly from OrthoDB:Sps1. Refer to their site for version information.
Paralogs
Downloads
Download All DIOPT Paralogs
Paralogs (via DIOPT v9.1)
Gene Symbol
Score
Source
Compara
Domainoid
eggNOG
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Drosophila melanogaster (Fruit fly) (1)
Sps2
10 of 13
Human Disease Associations
FlyBase Human Disease Model Reports
    Disease Ontology (DO) Annotations
    Models Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Evidence
    References
    Potential Models Based on Orthology ( 0 )
    Human Ortholog
    Disease
    Evidence
    References
    Modifiers Based on Experimental Evidence ( 3 )
    Allele
    Disease
    Interaction
    References
    Sps1GL00002
    exacerbates  tauopathy
    modeled by Hsap\MAPTUAS.cWa
    (Feuillette et al., 2020)
    Sps1KG08804
    exacerbates  tauopathy
    modeled by Hsap\MAPTUAS.cWa
    (Feuillette et al., 2020)
    Sps1JF03230
    exacerbates  tauopathy
    modeled by Hsap\MAPTUAS.cWa
    (Feuillette et al., 2020)
    Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)
    Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
    Homo sapiens (Human)
    Gene name
    Score
    OMIM
    OMIM Phenotype
    DO term
    Complementation?
    Transgene?
    SEPHS1; selenophosphate synthetase 1
    14 of 14
    600902
         
        SEPHS2; selenophosphate synthetase 2
        13 of 14
        606218
            Functional Complementation Data
            Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
            Interactions
            Summary of Physical Interactions
            esyN Network Diagram
            Show neighbor-neighbor interactions:
            Show/hide secondary interactors 
            (data from AllianceMine provided by esyN)
            Select Layout:
            Legend:
            Protein
            RNA
            Selected Interactor(s)
            Other Interaction Browsers
            View in FlyBase Interactions Browser   View in MIST tool (external link)
            Please see the Physical Interaction reports below for full details
            protein-protein
            Physical Interaction
            Assay
            References
            Sps1 - Arc42
            experimental knowledge based
            (Guruharsha et al., 2011)
            Sps1 - CG11839
            experimental knowledge based
            (Guruharsha et al., 2011)
            Sps1 - CG1910
            experimental knowledge based
            (Guruharsha et al., 2011)
            Sps1 - CG4860
            experimental knowledge based
            (Guruharsha et al., 2011)
            Sps1 - Clic
            experimental knowledge based
            (Guruharsha et al., 2011)
            Sps1 - r-l
            experimental knowledge based
            (Guruharsha et al., 2011)
            Summary of Genetic Interactions
            esyN Network Diagram
            Show/hide secondary interactors 
            (data from AllianceMine provided by esyN)
            esyN Network Key:
            Suppression
            Enhancement
            Other Interaction Browsers
            View in FlyBase Interactions Browser   View in MIST tool (external link)
            Please look at the allele data for full details of the genetic interactions
            Starting gene(s)
            Interaction type
            Interacting gene(s)
            Reference
            Starting gene(s)
            Interaction type
            Interacting gene(s)
            Reference
            Egfr
            suppressible
            Sps1
            (Morey et al., 2001)
            Raf::tor
            suppressible
            Sps1
            (Morey et al., 2001)
            Raf
            suppressible
            Sps1
            (Morey et al., 2001)
            sev
            suppressible
            Sps1
            (Morey et al., 2001)
            External Data
            Linkouts
            BioGRID - A database of protein and genetic interactions.
            DroID - A comprehensive database of gene and protein interactions.
            MIST (protein-protein) - An integrated Molecular Interaction Database
            Pathways
            Signaling Pathways (FlyBase)
            Metabolic Pathways
            FlyBase
            External Links
            KEGG Metabolic Pathways - A collection of manually drawn metabolic pathway maps representing knowledge of molecular interaction, reaction and relation networks.
            Reactome Metabolic Pathways - An open-source, open access, manually curated and peer-reviewed metabolic pathway database.
            External Data
            Linkouts
            KEGG Pathways - A collection of manually drawn pathway maps representing knowledge of molecular interaction, reaction and relation networks.
            Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
            Class of Gene
            Genomic Location and Detailed Mapping Data
            Chromosome (arm)
            2R
            Recombination map
            2-69
            Cytogenetic map
            50E6-50E6
            Sequence location
            FlyBase Computed Cytological Location
            Cytogenetic map
            Evidence for location
            50E6-50E6
            Limits computationally determined from genome sequence between P{lacW}l(2)s3475s3475&P{lacW}Hsc70-5k04907 and P{PZ}Tfb106949&P{PZ}l(2)0356303563
            Experimentally Determined Cytological Location
            Cytogenetic map
            Notes
            References
            50E8-50E8
            (Oh et al., 2003)
            50D-50E
            (Vorbrüggen, 1997.7.31)
            50E-50E
            (Alsina, 1997.3.5)
            50E4-50E7
            (determined by in situ hybridisation)
            (Spradling et al., 1999)
            50E-50E
            (determined by in situ hybridisation)
            (Alsina et al., 1998, Roch et al., 1998)
            50D-50E
            (determined by in situ hybridisation)
            (Persson et al., 1997)
            50E4-50E7
            50E8--9
            (BDGP Project Members, 1994-1999)
            Experimentally Determined Recombination Data
            Location

            2-69

            (FlyBase, 2016)

            2-74.9

            (Comeron et al., 2012)
            Left of (cM)
            Right of (cM)
            Notes
            Stocks and Reagents
            Stocks (13)
            Genomic Clones (15)
             

            Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

            cDNA Clones (59)
             

            Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

            cDNA clones, fully sequenced
            BDGP DGC clones
            Other clones
            Drosophila Genomics Resource Center cDNA clones

            For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

            cDNA Clones, End Sequenced (ESTs)
            BDGP DGC clones
            Other clones
            RNAi and Array Information
            Linkouts
            DRSC - Results frm RNAi screens
            Antibody Information
            Laboratory Generated Antibodies
             

            polyclonal

            (Shim et al., 2009)
            Commercially Available Antibodies
             
            Cell Line Information
            Publicly Available Cell Lines
             
              Other Stable Cell Lines
               
                Other Comments

                2 alleles of l(2)SH1599 recovered in a P-insertion screen.

                (Oh et al., 2003)

                SelD may modulate the Ras/MAPK pathway.

                (Morey et al., 2001)

                Mutation in SelD results in a reduction in cell proliferation in the imaginal discs and brain in larvae.

                (Alsina et al., 1999)

                Isolation and characterisation of SelD, SelD encodes the homologue of selenophosphate synthetase.

                (Alsina et al., 1998)

                Loss of SelD function leads to apoptosis.

                (Alsina et al., 1998)

                Mutants isolated in a screen of the second chromosome identifying gene affecting disc morphology.

                (Roch et al., 1998)

                Genetic and biochemical analysis of SelD.

                (Persson et al., 1997)
                Relationship to Other Genes
                Source for database merge of

                Source for merge of: SelD l(2)SH1599

                (Swanson et al., 2009)

                Source for merge of: SelD anon-WO0172774.145 anon-WO0172774.146

                (FlyBase, 1996-)
                Additional comments

                The SelD gene may have been derived from the Sps2 gene by retroposition.

                (Pan and Zhang, 2009)

                Source for merge of SelD anon-WO0172774.145 anon-WO0172774.146 was sequence comparison ( date:051113 ).

                (FlyBase, 1996-)
                Nomenclature History
                Source for database identify of

                Source for identity of: Sps1 SelD

                (Hirosawa-Takamori et al., 2000)
                Nomenclature comments
                Etymology
                Synonyms and Secondary IDs (31)
                Reported As
                Symbol Synonym
                142926_at
                (Kristensen et al., 2005)
                CG8553
                (National Institute of Genetics Fly Stocks, 2022-, Çiçek et al., 2016, Hosono et al., 2015, Ni et al., 2011.7.19, Keleman et al., 2009.8.5, Pan and Zhang, 2009, Perkins et al., 2009, Swanson et al., 2009, Tang et al., 2003)
                DSPS1
                (Hirosawa-Takamori et al., 2000)
                Dm SelD
                (Hirosawa-Takamori et al., 2000)
                Dm-SelD
                (Persson et al., 1997)
                Dsps1
                (Hirosawa-Takamori et al., 2000)
                SPS1
                (Labunskyy et al., 2014, Shim et al., 2009, Chapple and Guigó, 2008, Lobanov et al., 2008, Martin-Romero et al., 2001)
                SeS
                (Alsina et al., 1996)
                SelD
                (Feuillette et al., 2020, Ugrankar et al., 2015, dos Santos, 2014, Handler et al., 2013, Handler et al., 2013, Japanese National Institute of Genetics, 2012.5.21, Doumanis et al., 2009, Shim et al., 2009, Samsonova et al., 2007)
                SelD like
                (Hirosawa-Takamori et al., 2000)
                Sps1
                (Nieken et al., 2023, Yoo et al., 2022)
                anon-WO0172774.145
                anon-WO0172774.146
                dSPS1
                (Jin et al., 2004)
                dsps1
                (Jin et al., 2004)
                l(2)SH1599
                l(2)SH2 1599
                (Oh et al., 2002.3.26)
                l(2)k12303
                ptf1
                ptuf
                (Alsina et al., 1999, Corominas et al., 1999, Alsina et al., 1998)
                ptuf1
                (Alsina, 1997.3.5)
                selD
                (Wang et al., 2012, Swanson et al., 2009, Morey et al., 2003, Morey et al., 2003, Morey et al., 2002, Morey et al., 2001)
                selD/sps1
                (Morey et al., 2003)
                Name Synonyms
                Selenide,water dikinase
                (Pedersen et al., 2008)
                Selenophosphate synthetase
                (Alsina et al., 1996)
                Selenophosphate synthetase 1
                lethal (2) SH1599
                patufet
                (Shim et al., 2009, Alsina et al., 1998)
                selD-like
                (Vorbrüggen, 1997.7.31)
                selenide,water dikinase
                (Samsonova et al., 2007)
                selenophosphate synthetase 1
                (Shim et al., 2009, Jin et al., 2004)
                Secondary FlyBase IDs
                • FBgn0020615
                • FBgn0021903
                • FBgn0046452
                • FBgn0046453
                • FBgn0065403
                Datasets (0)
                Study focus (0)
                Experimental Role
                Project
                Project Type
                Title
                Study result (0)
                Result
                Result Type
                Title
                External Crossreferences and Linkouts ( 54 )
                Sequence Crossreferences
                NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
                GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
                GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
                RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
                UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.
                UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information
                Other crossreferences
                AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.
                BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
                DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
                EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
                FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
                InterPro - A database of protein families, domains and functional sites
                KEGG Genes - Molecular building blocks of life in the genomic space.
                MARRVEL_MODEL - MARRVEL (model organism gene)
                Linkouts
                BioGRID - A database of protein and genetic interactions.
                Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones
                DroID - A comprehensive database of gene and protein interactions.
                DRSC - Results frm RNAi screens
                Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
                FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
                FlyCyc Genes - Genes from a BioCyc PGDB for Dmel
                Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
                Flygut - An atlas of the Drosophila adult midgut
                FlyMet - A comprehensive tissue-specific metabolomics resource for Drosophila.
                iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)
                KEGG Metabolic Pathways - A collection of manually drawn metabolic pathway maps representing knowledge of molecular interaction, reaction and relation networks.
                KEGG Pathways - A collection of manually drawn pathway maps representing knowledge of molecular interaction, reaction and relation networks.
                MIST (protein-protein) - An integrated Molecular Interaction Database
                Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
                Reactome Metabolic Pathways - An open-source, open access, manually curated and peer-reviewed metabolic pathway database.
                References (87)