FB2020_06, released Dec 22, 2020

Gene: Dmel\Ero1L

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General Information
Symbol
Dmel\Ero1L
Species
D. melanogaster
Name
Endoplasmic reticulum oxidoreductin-1-like
Annotation Symbol
CG1333
Feature Type
protein_coding_gene
FlyBase ID
FBgn0261274
Gene Model Status
Current
Stock Availability
10 publicly available
Gene Snapshot
Contributions welcome
Other Summaries
Also Known As

kiga

Key Links
Genomic Location
Cytogenetic map
64A9-64A9
Sequence location
3L:4,170,404..4,173,789 [+]
Recombination map

3-10

RefSeq locus
NT_037436 REGION:4170404..4173789
Sequence
Get Decorated FASTA
Genomic Maps
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
NCBI
UCSC
Ensembl
PopFly
Function
GO Summary Ribbons
Gene Ontology (GO) Annotations (10 terms)
Molecular Function (5 terms)
Terms Based on Experimental Evidence (1 term)
CV Term
Evidence
References
enables thiol oxidase activity
inferred from mutant phenotype
(Tien et al., 2008)
Terms Based on Predictions or Assertions (4 terms)
CV Term
Evidence
References
enables oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor
inferred from electronic annotation with InterPro:IPR007266
(assigned by InterPro )
(FlyBase Curators et al., 2004-)
enables oxidoreductase activity
inferred from sequence or structural similarity with UniProtKB:Q96HE7
(assigned by UniProt )
(UniProt Curators, 2002-)
enables protein disulfide isomerase activity
inferred from biological aspect of ancestor with PANTHER:PTN000289179
(assigned by GO_Central )
(Gaudet et al., 2011)
enables protein disulfide oxidoreductase activity
inferred from biological aspect of ancestor with PANTHER:PTN000289179
(assigned by GO_Central )
(Gaudet et al., 2011)
Biological Process (3 terms)
Terms Based on Experimental Evidence (1 term)
CV Term
Evidence
References
involved_in protein folding in endoplasmic reticulum
inferred from mutant phenotype
(Tien et al., 2008)
Terms Based on Predictions or Assertions (3 terms)
CV Term
Evidence
References
involved_in chaperone cofactor-dependent protein refolding
inferred from sequence or structural similarity with UniProtKB:Q96HE7
(assigned by UniProt )
(UniProt Curators, 2002-)
involved_in oxidation-reduction process
inferred from electronic annotation with InterPro:IPR007266
(assigned by InterPro )
(FlyBase Curators et al., 2004-)
involved_in protein folding in endoplasmic reticulum
inferred from biological aspect of ancestor with PANTHER:PTN000289179
(assigned by GO_Central )
(Gaudet et al., 2011)
Cellular Component (2 terms)
Terms Based on Experimental Evidence (0 terms)
Terms Based on Predictions or Assertions (2 terms)
CV Term
Evidence
References
located_in endoplasmic reticulum membrane
inferred from biological aspect of ancestor with PANTHER:PTN000289179
(assigned by GO_Central )
(Gaudet et al., 2011)
located_in endoplasmic reticulum
inferred from sequence or structural similarity with UniProtKB:Q96HE7
(assigned by UniProt )
(UniProt Curators, 2002-)
Gene Group (FlyBase)
Protein Family (UniProt)
Belongs to the EROs family. (Q9V3A6)
Protein Signatures (InterPro)
Summaries
Gene Group (FlyBase)
SULFUR OXIDOREDUCTASES, DISULFIDE AS ACCEPTOR -
Sulfur oxidoreductases with disulfide as acceptor, include dehydrogenases that oxidize sulfur-containing group with the reduction of disulfide.
DISULFIDE OXIDOREDUCTASES -
Disulfide oxidoreductases include dehydrogenases that catalyze the oxidation of substrate with reduced sulfide groups into substrate with oxidized disulfide bonds.
Protein Function (UniProtKB)
Oxidoreductase involved in disulfide bond formation in the endoplasmic reticulum. Efficiently reoxidizes pdi-1, the enzyme catalyzing protein disulfide formation, in order to allow pdi-1 to sustain additional rounds of disulfide formation. Following pdi reoxidation, passes its electrons to molecular oxygen via FAD, leading to the production of reactive oxygen species (ROS) in the cell (By similarity).
(UniProt, Q9V3A6)
Gene Model and Products
Number of Transcripts
1
Number of Unique Polypeptides
1

Please see the JBrowse view of Dmel\Ero1L for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Comments on Gene Model

Gene model reviewed during 5.44

Low-frequency RNA-Seq exon junction(s) not annotated.

Gene model reviewed during 5.45

Sequence Ontology: Class of Gene
gene
nuclear_gene
protein_coding_gene
Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
Ero1L-RB
FBtr0073217
NM_139608
2100
483
Additional Transcript Data and Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
RefSeq ID
GenBank
Ero1L-PB
FBpp0073073
55.7
483
5.20
NP_647865
AAN11590
Polypeptides with Identical Sequences

There is only one protein coding transcript and one polypeptide associated with this gene

Additional Polypeptide Data and Comments
Reported size (kDa)

416 (aa)

(Cabibbo et al., 2000)
Comments
External Data
Subunit Structure (UniProtKB)

May function both as a monomer and a homodimer.

(UniProt, Q9V3A6)
Crossreferences
InterPro - A database of protein families, domains and functional sites
Linkouts
Sequences Consistent with the Gene Model
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Ero1L using the Feature Mapper tool.

External Data
Crossreferences
Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
Linkouts
Expression Data
Expression Summary Ribbons
Colored tiles in ribbon indicate that expression data has been curated by FlyBase for that anatomical location. Colorless tiles indicate that there is no curated data for that location.
For complete stage-specific expression data, view the modENCODE Development RNA-Seq section under High-Throughput Expression below.
Transcript Expression
in situ
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage 10 -- 11
embryonic/larval trachea
(Chung et al., 2011)
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Polypeptide Expression
mass spectroscopy
Stage
Tissue/Position (including subcellular localization)
Reference
day 7 of adulthood -- day 49 of adulthood
adult heart
(Cammarato et al., 2011)
adult stage
adult head
(Aradska et al., 2015)
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Evidence
References
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\Ero1L in GBrowse 2
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Bulk Downloads
RNA-Seq RPKM values for all genes
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
FLIGHT - Cell culture data for RNAi and other high-throughput technologies
Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
Flygut - An atlas of the Drosophila adult midgut
Images
FlyBase Wiki
Image Based Resources
Alleles, Insertions, and Transgenic Constructs
Classical and Insertion Alleles ( 10 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 4 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of Ero1L
Transgenic constructs containing regulatory region of Ero1L
Deletions and Duplications ( 12 )
Phenotypes
Orthologs
Downloads
Download All DIOPT Orthologs
Download All OrthoDB Orthologs
Human Orthologs (via DIOPT v8.0)
Homo sapiens (Human) (2)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
eggNOG
Hieranoid
Homologene
Inparanoid
Isobase
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
RoundUp
TreeFam
ZFIN
Alignment
Complementation?
Transgene?
Hsap\ERO1B
13 of 15
Yes
Yes
Hsap\ERO1A
12 of 15
No
Yes
2  
Model Organism Orthologs (via DIOPT v8.0)
Mus musculus (laboratory mouse) (3)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
eggNOG
Hieranoid
Homologene
Inparanoid
Isobase
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
RoundUp
TreeFam
ZFIN
Alignment
Complementation?
Transgene?
Mmus\Ero1lb
12 of 15
Yes
Yes
Mmus\Ero1l
12 of 15
Yes
Yes
Mmus\Cox5a
1 of 15
No
No
Rattus norvegicus (Norway rat) (2)
Rnor\Ero1b
12 of 13
Yes
Yes
Rnor\Ero1a
10 of 13
No
Yes
Xenopus tropicalis (Western clawed frog) (2)
Xtro\ero1a
12 of 12
Yes
Yes
Xtro\ero1b
9 of 12
No
Yes
Danio rerio (Zebrafish) (2)
Drer\ero1a
11 of 15
Yes
Yes
Drer\ero1b
11 of 15
Yes
Yes
Caenorhabditis elegans (Nematode, roundworm) (1)
Cele\ero-1
14 of 15
Yes
Yes
Arabidopsis thaliana (thale-cress) (2)
Atha\ERO1
7 of 9
Yes
Yes
Atha\ERO2
7 of 9
Yes
Yes
Saccharomyces cerevisiae (Brewer's yeast) (1)
Scer\ERO1
12 of 15
Yes
Yes
Schizosaccharomyces pombe (Fission yeast) (2)
Spom\ero12
9 of 12
Yes
Yes
Spom\ero11
7 of 12
No
Yes
Ortholog(s) in Drosophila Species (via OrthoDB v9.1) ( EOG091906WZ )
Organism
Common Name
Gene
AAA Syntenic Ortholog
Multiple Dmel Genes in this Orthologous Group
Drosophila simulans
Dsim\GD28835
Drosophila sechellia
Dsec\GM14630
Drosophila erecta
Dere\GG15199
Drosophila yakuba
Dyak\GE21418
Drosophila ananassae
Dana\GF10559
Drosophila pseudoobscura pseudoobscura
Dpse\GA28655
Drosophila persimilis
Dper\GL12831
Drosophila willistoni
Dwil\GK12704
Drosophila virilis
Dvir\GJ12829
Drosophila mojavensis
Dmoj\GI16577
Drosophila grimshawi
Dgri\GH15928
Orthologs in non-Drosophila Dipterans (via OrthoDB v9.1) ( EOG091505LV )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Musca domestica
House fly
Mdoa\17011854
Glossina morsitans
Tsetse fly
Gmor\GMOY003070
Lucilia cuprina
Australian sheep blowfly
Lcup\FF38_00637
Mayetiola destructor
Hessian fly
Mdes\Mdes007200
Mayetiola destructor
Hessian fly
Mdes\Mdes007195
Aedes aegypti
Yellow fever mosquito
Aaeg\AAEL002102
Anopheles darlingi
American malaria mosquito
Adar\ADAC006477
Anopheles gambiae
Malaria mosquito
Agam\AGAP002816
Culex quinquefasciatus
Southern house mosquito
Cqui\CPIJ004301
Orthologs in non-Dipteran Insects (via OrthoDB v9.1) ( EOG090W03DE )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Bombyx mori
Silkmoth
Bmor\BGIBMGA002793
Danaus plexippus
Monarch butterfly
Dple\DPOGS200151-PA
Heliconius melpomene
Postman butterfly
Hmel\HMEL005833
Apis florea
Little honeybee
Aflo\2417178822
Apis mellifera
Western honey bee
Amel\Ero1L
Bombus impatiens
Common eastern bumble bee
Bimp\BIMP16904
Bombus terrestris
Buff-tailed bumblebee
Bter\15214835
Linepithema humile
Argentine ant
Lhum\LH18568
Megachile rotundata
Alfalfa leafcutting bee
Mrot\MROTU:000b11
Nasonia vitripennis
Parasitic wasp
Nvit\Nasvi2EG004353
Dendroctonus ponderosae
Mountain pine beetle
Dpod\YQE_12221
Tribolium castaneum
Red flour beetle
Tcas\TC004626
Tribolium castaneum
Red flour beetle
Tcas\TC006568
Pediculus humanus
Human body louse
Phum\PHUM079830
Rhodnius prolixus
Kissing bug
Rpro\RPRC005945
Cimex lectularius
Bed bug
Clec\CLEC009548
Acyrthosiphon pisum
Pea aphid
Apim\ACYPI010248
Zootermopsis nevadensis
Nevada dampwood termite
Znev\Znev_17667
Orthologs in non-Insect Arthropods (via OrthoDB v9.1) ( EOG090X03A4 )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strigamia maritima
European centipede
Smar\SMAR014444
Ixodes scapularis
Black-legged tick
Isca\ISCW019491
Stegodyphus mimosarum
African social velvet spider
Smim\KFM74413.1
Stegodyphus mimosarum
African social velvet spider
Smim\KFM75641.1
Tetranychus urticae
Two-spotted spider mite
Turt\tetur09g02760
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_308173
Orthologs in non-Arthropod Metazoa (via OrthoDB v9.1) ( EOG091G04ZQ )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Ero1L
Ciona intestinalis
Vase tunicate
Cint\ENSCING00000004266
Gallus gallus
Domestic chicken
Ggal\ERO1LB
Gallus gallus
Domestic chicken
Ggal\ERO1L
Paralogs
Downloads
Download All DIOPT Paralogs
Paralogs (via DIOPT v8.0)
Drosophila melanogaster (Fruit fly) (0)
No records found.
Human Disease Associations
FlyBase Human Disease Model Reports
    Disease Model Summary Ribbon
    Disease Ontology (DO) Annotations
    Models Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Evidence
    References
    Potential Models Based on Orthology ( 0 )
    Human Ortholog
    Disease
    Evidence
    References
    Modifiers Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Interaction
    References
    Disease Associations of Human Orthologs (via DIOPT v8.0 and OMIM)
    Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
    Homo sapiens (Human)
    Gene name
    Score
    OMIM
    OMIM Phenotype
    DO term
    Complementation?
    Transgene?
    ERO1B; endoplasmic reticulum oxidoreductase 1 beta
    13 of 15
    615437
        ERO1A; endoplasmic reticulum oxidoreductase 1 alpha
        12 of 15
        615435
             
            Functional Complementation Data
            Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
            Interactions
            Summary of Physical Interactions
            esyN Network Diagram
            Interactions Browser
            Summary of Genetic Interactions
            esyN Network Diagram
            esyN Network Key:
            Suppression
            Enhancement
            View in Interactions Browser
            Please look at the allele data for full details of the genetic interactions
            Starting gene(s)
            Interaction type
            Interacting gene(s)
            Reference
            Ero1L
            suppressible
            cnc
            (Wang et al., 2015)
            Ero1L
            suppressible
            PEK
            (Wang et al., 2015)
            Ero1L
            suppressible
            Xbp1
            (Wang et al., 2015)
            Starting gene(s)
            Interaction type
            Interacting gene(s)
            Reference
            N
            suppressible
            Ero1L
            (Tien et al., 2008)
            External Data
            Subunit Structure (UniProtKB)
            May function both as a monomer and a homodimer.
            (UniProt, Q9V3A6 )
            Linkouts
            DroID - A comprehensive database of gene and protein interactions.
            InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.
            Pathways
            Signaling Pathways (FlyBase)
            Metabolic Pathways
            External Data
            Linkouts
            KEGG Pathways - Wiring diagrams of molecular interactions, reactions and relations.
            Genomic Location and Detailed Mapping Data
            Chromosome (arm)
            3L
            Recombination map

            3-10

            Cytogenetic map
            64A9-64A9
            Sequence location
            3L:4,170,404..4,173,789 [+]
            FlyBase Computed Cytological Location
            Cytogenetic map
            Evidence for location
            64A9-64A9
            Limits computationally determined from genome sequence between P{PZ}l(3)rG166rG166 and P{PZ}sinu06524
            Experimentally Determined Cytological Location
            Cytogenetic map
            Notes
            References
            Experimentally Determined Recombination Data
            Location

            3-10

            (FlyBase, 2016)

            3-8.9

            (Comeron et al., 2012)
            Left of (cM)
            Right of (cM)
            Notes
            Stocks and Reagents
            Stocks (10)
            Genomic Clones (11)
             

            Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

            cDNA Clones (93)
             

            Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

            cDNA clones, fully sequenced
            BDGP DGC clones
            Other clones
              Drosophila Genomics Resource Center cDNA clones

              For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

              cDNA Clones, End Sequenced (ESTs)
              BDGP DGC clones
              Other clones
              RNAi and Array Information
              Linkouts
              DRSC - Results frm RNAi screens
              GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
              Antibody Information
              Laboratory Generated Antibodies
               
              Commercially Available Antibodies
               
              Other Information
              Relationship to Other Genes
              Source for database identify of

              Source for identity of: Ero1L CG1333

              (Gabrielian, 1999.11)

              Source for identity of: Ero1L kiga

              (Tien, 2006.2.28)
              Source for database merge of

              Source for merge of: Ero1L l(3)64Ag

              (Tien et al., 2008)
              Additional comments
              Other Comments

              Ero1L is specifically required for lateral inhibition but not for cell fate decisions and differentiation.

              (Tien et al., 2008)

              Discussed during genetic analysis of the Ras64B-Rop region.

              (Harrison et al., 1995)
              Origin and Etymology
              Discoverer
              Etymology

              Named 'kiga', which is phonetic for 'notched' in Taiwanese.

              (Tien et al., 2008)
              Identification
              External Crossreferences and Linkouts ( 29 )
              Sequence Crossreferences
              NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
              GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
              GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
              RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
              UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information
              Other crossreferences
              Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones
              Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
              Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
              Flygut - An atlas of the Drosophila adult midgut
              FlyMine - An integrated database for Drosophila genomics
              GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
              iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)
              InterPro - A database of protein families, domains and functional sites
              KEGG Genes - Molecular building blocks of life in the genomic space.
              modMine - A data warehouse for the modENCODE project
              Linkouts
              DroID - A comprehensive database of gene and protein interactions.
              DRSC - Results frm RNAi screens
              FLIGHT - Cell culture data for RNAi and other high-throughput technologies
              InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.
              KEGG Pathways - Wiring diagrams of molecular interactions, reactions and relations.
              Synonyms and Secondary IDs (12)
              Datasets (0)
              Study focus (0)
              Experimental Role
              Project
              Project Type
              Title
              References (45)