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Gene Dmel\rtv

General Information
Symbol	Dmel\rtv	Species	D. melanogaster
Name	retroactive	Annotation symbol	CG1397
Feature type	protein_coding_gene	FlyBase ID	FBgn0261277
Gene Model Status	Current	Stock availability	5 publicly available
Also Known As	l(1)L1, 1
Genomic Location
Chromosome (arm)	X	Recombination map
Cytogenetic map	10A8-10A9	Sequence location	X:11,046,511..11,047,812 [-]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents modENCODE GBrowse	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene retroactive is referred to in FlyBase by the symbol Dmel\rtv (CG1397, FBgn0261277). It is a protein_coding_gene from Drosophila melanogaster. Its molecular function is unknown. There is experimental evidence that it is involved in the biological process: regulation of tube diameter, open tracheal system; chitin biosynthetic process; regulation of tube architecture, open tracheal system; open tracheal system development; chitin-based embryonic cuticle biosynthetic process. 17 alleles are reported. The phenotypes of these alleles are annotated with: embryonic/first instar larval cuticle; cephalopharyngeal skeleton; procuticle; epicuticle; embryonic/larval tracheal system; presumptive embryonic/larval tracheal system; dorsal trunk primordium; embryo; denticle belt. It has one annotated transcript and one annotated polypeptide. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of very low expression. Peak expression observed during early pupal stages. Summary of FlyAtlas Anatomical Expression Data: Expression at moderate levels in the following post-embryonic organs or tissues: larval hindgut, larval trachea, larval carcass. Comments on Affy2 ProbeSet: ProbeSet 1641039_at completely aligns to an exonic region of the only FlyBase-annotated transcript isoform of rtv. Gene sequence location is X:11046511..11047812.
Phenotypic Description from the Red Book (Lindsley & Zimm 1992)
Gene/Allele symbols may differ from current usage	rtv: retroactive Recessive embryonic lethal; mouth parts darkly sclerotized. Embryo sometimes reversed in egg case (due to hyperactivity at late stages?). Zygotes from homozygous germ-line clones in females develop normally (Wieschaus and Noell, 1986, Roux's Arch. Dev. Biol. 195: 63-73).
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2012_01
FB2011_10
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 10A8-10A9   Limits computationally determined from genome sequence between P{EP}EP1321EP1321&P{EP}CG2061EP1537 and P{EP}CG11756EP1610; Left limit from recombination mapping relative to l(1)10Ae (FBrf0035977) Right limit from non-inclusion within Df(1)KA7 (FBrf0035977)
Experimentally Determined Cytological Location
Cytogenetic map Notes References
Experimentally Determined Recombination Data
Location	1-33.64 (Geer et al., 1983) 1-38 (Tearle and Nusslein-Volhard, 1987)
Left of (cM)	dsh (Zhimulev et al., 1981)
Right of (cM)	Hsp60 l(1)10Ae (Zhimulev et al., 1981)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\rtv for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) rtv-RA FBtr0073470  NM_132465   1046   151
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein rtv-PA   FBpp0073326   16.8   151   5.12     NP_572693   AAF48010
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA391822   AE014298 AAF48010   AW942152   AY061126 AAL28674   BI375282   CA805678   CK604416   EC238498
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL	Q9VZ21
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
Polypeptide Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
High-Throughput Expression Data
or
See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes. modENCODE Temporal Expression Data for FBgn0261277    Styles Linear Logarithmic Heatmap    Scales max expr for FBgn0261277 Very low expression bin max Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of very low expression. Peak expression observed during early pupal stages. [download data (TSV)] Guide to modENCODE expression level colors   No expression (0 - 0)   Extremely low expression (1 - 10)   Very low expression (11 - 100)   Low expression (101 - 400)   Moderate expression (401 - 1400)   Moderately high expression (1401 - 4000)   High expression (4001 - 10000)   Very high expression (10001 - 100000)   Extremely high expression (100001 - 2000000) Linear, scaled to maximum FBgn0261277 expression level Developmental Stage   Expression Level embryo 00-02hr    53 embryo 02-04hr    313 embryo 04-06hr    551 embryo 06-08hr    1193 embryo 08-10hr    1923 embryo 10-12hr    3068 embryo 12-14hr    1445 embryo 14-16hr    2202 embryo 16-18hr    1518 embryo 18-20hr    1237 embryo 20-22hr    854 embryo 22-24hr    641 larva L1    1064 larva L2    1167 larva L3 12hr old    1321 larva L3 puffstage 1-2    1183 larva L3 puffstage 3-6    1632 larva L3 puffstage 7-9    2001 white prepupae new    2434 white prepupae 12hr    5484 white prepupae 24hr    3753 pupae 2d postWPP    3625 pupae 3d postWPP    1577 pupae 4d postWPP    1406 adult male 01day    640 adult male 05day    395 adult male 30day    466 adult female 01day    661 adult female 05day    78 adult female 30day    135 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High  Linear, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr    53 embryo 02-04hr  (313) embryo 04-06hr  (551) embryo 06-08hr  (1193) embryo 08-10hr  (1923) embryo 10-12hr  (3068) embryo 12-14hr  (1445) embryo 14-16hr  (2202) embryo 16-18hr  (1518) embryo 18-20hr  (1237) embryo 20-22hr  (854) embryo 22-24hr  (641) larva L1  (1064) larva L2  (1167) larva L3 12hr old  (1321) larva L3 puffstage 1-2  (1183) larva L3 puffstage 3-6  (1632) larva L3 puffstage 7-9  (2001) white prepupae new  (2434) white prepupae 12hr  (5484) white prepupae 24hr  (3753) pupae 2d postWPP  (3625) pupae 3d postWPP  (1577) pupae 4d postWPP  (1406) adult male 01day  (640) adult male 05day  (395) adult male 30day  (466) adult female 01day  (661) adult female 05day    78 adult female 30day  (135) Expression Level Scale  None   Extremely low   Very low   Low  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    53 embryo 02-04hr    313 embryo 04-06hr    551 embryo 06-08hr    1193 embryo 08-10hr  (1923) embryo 10-12hr  (3068) embryo 12-14hr  1445 embryo 14-16hr  (2202) embryo 16-18hr  (1518) embryo 18-20hr    1237 embryo 20-22hr    854 embryo 22-24hr    641 larva L1    1064 larva L2    1167 larva L3 12hr old    1321 larva L3 puffstage 1-2    1183 larva L3 puffstage 3-6  (1632) larva L3 puffstage 7-9  (2001) white prepupae new  (2434) white prepupae 12hr  (5484) white prepupae 24hr  (3753) pupae 2d postWPP  (3625) pupae 3d postWPP  (1577) pupae 4d postWPP  1406 adult male 01day    640 adult male 05day    395 adult male 30day    466 adult female 01day    661 adult female 05day    78 adult female 30day    135 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    53 embryo 02-04hr    313 embryo 04-06hr    551 embryo 06-08hr    1193 embryo 08-10hr    1923 embryo 10-12hr    3068 embryo 12-14hr    1445 embryo 14-16hr    2202 embryo 16-18hr    1518 embryo 18-20hr    1237 embryo 20-22hr    854 embryo 22-24hr    641 larva L1    1064 larva L2    1167 larva L3 12hr old    1321 larva L3 puffstage 1-2    1183 larva L3 puffstage 3-6    1632 larva L3 puffstage 7-9    2001 white prepupae new    2434 white prepupae 12hr    5484 white prepupae 24hr    3753 pupae 2d postWPP    3625 pupae 3d postWPP    1577 pupae 4d postWPP    1406 adult male 01day    640 adult male 05day    395 adult male 30day    466 adult female 01day    661 adult female 05day    78 adult female 30day    135 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    53 embryo 02-04hr    313 embryo 04-06hr    551 embryo 06-08hr    1193 embryo 08-10hr    1923 embryo 10-12hr    3068 embryo 12-14hr    1445 embryo 14-16hr    2202 embryo 16-18hr    1518 embryo 18-20hr    1237 embryo 20-22hr    854 embryo 22-24hr    641 larva L1    1064 larva L2    1167 larva L3 12hr old    1321 larva L3 puffstage 1-2    1183 larva L3 puffstage 3-6    1632 larva L3 puffstage 7-9    2001 white prepupae new    2434 white prepupae 12hr    5484 white prepupae 24hr    3753 pupae 2d postWPP    3625 pupae 3d postWPP    1577 pupae 4d postWPP    1406 adult male 01day    640 adult male 05day    395 adult male 30day    466 adult female 01day    661 adult female 05day    78 adult female 30day    135 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  log, scaled to maximum FBgn0261277 expression level Developmental Stage   Expression Level embryo 00-02hr    53 embryo 02-04hr    313 embryo 04-06hr    551 embryo 06-08hr    1193 embryo 08-10hr    1923 embryo 10-12hr    3068 embryo 12-14hr    1445 embryo 14-16hr    2202 embryo 16-18hr    1518 embryo 18-20hr    1237 embryo 20-22hr    854 embryo 22-24hr    641 larva L1    1064 larva L2    1167 larva L3 12hr old    1321 larva L3 puffstage 1-2    1183 larva L3 puffstage 3-6    1632 larva L3 puffstage 7-9    2001 white prepupae new    2434 white prepupae 12hr    5484 white prepupae 24hr    3753 pupae 2d postWPP    3625 pupae 3d postWPP    1577 pupae 4d postWPP    1406 adult male 01day    640 adult male 05day    395 adult male 30day    466 adult female 01day    661 adult female 05day    78 adult female 30day    135 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr    53 embryo 02-04hr  (313) embryo 04-06hr  (551) embryo 06-08hr  (1193) embryo 08-10hr  (1923) embryo 10-12hr  (3068) embryo 12-14hr  (1445) embryo 14-16hr  (2202) embryo 16-18hr  (1518) embryo 18-20hr  (1237) embryo 20-22hr  (854) embryo 22-24hr  (641) larva L1  (1064) larva L2  (1167) larva L3 12hr old  (1321) larva L3 puffstage 1-2  (1183) larva L3 puffstage 3-6  (1632) larva L3 puffstage 7-9  (2001) white prepupae new  (2434) white prepupae 12hr  (5484) white prepupae 24hr  (3753) pupae 2d postWPP  (3625) pupae 3d postWPP  (1577) pupae 4d postWPP  (1406) adult male 01day  (640) adult male 05day  (395) adult male 30day  (466) adult female 01day  (661) adult female 05day    78 adult female 30day  135 Expression Level Scale  None   Extremely low   Very low   Low  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    53 embryo 02-04hr    313 embryo 04-06hr    551 embryo 06-08hr    1193 embryo 08-10hr  1923 embryo 10-12hr  (3068) embryo 12-14hr  1445 embryo 14-16hr  2202 embryo 16-18hr  1518 embryo 18-20hr    1237 embryo 20-22hr    854 embryo 22-24hr    641 larva L1    1064 larva L2    1167 larva L3 12hr old    1321 larva L3 puffstage 1-2    1183 larva L3 puffstage 3-6  1632 larva L3 puffstage 7-9  2001 white prepupae new  2434 white prepupae 12hr  (5484) white prepupae 24hr  (3753) pupae 2d postWPP  (3625) pupae 3d postWPP  1577 pupae 4d postWPP  1406 adult male 01day    640 adult male 05day    395 adult male 30day    466 adult female 01day    661 adult female 05day    78 adult female 30day    135 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    53 embryo 02-04hr    313 embryo 04-06hr    551 embryo 06-08hr    1193 embryo 08-10hr    1923 embryo 10-12hr    3068 embryo 12-14hr    1445 embryo 14-16hr    2202 embryo 16-18hr    1518 embryo 18-20hr    1237 embryo 20-22hr    854 embryo 22-24hr    641 larva L1    1064 larva L2    1167 larva L3 12hr old    1321 larva L3 puffstage 1-2    1183 larva L3 puffstage 3-6    1632 larva L3 puffstage 7-9    2001 white prepupae new    2434 white prepupae 12hr    5484 white prepupae 24hr    3753 pupae 2d postWPP    3625 pupae 3d postWPP    1577 pupae 4d postWPP    1406 adult male 01day    640 adult male 05day    395 adult male 30day    466 adult female 01day    661 adult female 05day    78 adult female 30day    135 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    53 embryo 02-04hr    313 embryo 04-06hr    551 embryo 06-08hr    1193 embryo 08-10hr    1923 embryo 10-12hr    3068 embryo 12-14hr    1445 embryo 14-16hr    2202 embryo 16-18hr    1518 embryo 18-20hr    1237 embryo 20-22hr    854 embryo 22-24hr    641 larva L1    1064 larva L2    1167 larva L3 12hr old    1321 larva L3 puffstage 1-2    1183 larva L3 puffstage 3-6    1632 larva L3 puffstage 7-9    2001 white prepupae new    2434 white prepupae 12hr    5484 white prepupae 24hr    3753 pupae 2d postWPP    3625 pupae 3d postWPP    1577 pupae 4d postWPP    1406 adult male 01day    640 adult male 05day    395 adult male 30day    466 adult female 01day    661 adult female 05day    78 adult female 30day    135 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     FlyAtlas Anatomical Expression Data for FBgn0261277    Styles Linear Logarithmic Heatmap Back-to-back    Scales max expr for FBgn0261277 Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Expression at moderate levels in the following post-embryonic organs or tissues: larval hindgut, larval trachea, larval carcass. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (1000 - 25000) Linear, scaled to maximum FBgn0261277 expression level Tissue   Expression Level Larval Central Nervous System    54.7 Larval Midgut no informative data Larval Hindgut    103.5 Larval Malpighian Tubules    2.9 Larval Fat Body    4.8 Larval Salivary Gland no informative data Larval Trachea    393.425 Larval Carcass    136.55 Adult Head    32.4 Adult Eye    58.05 Adult Brain    5.1 Adult Thoracic-Abdominal Ganglion    6.8 Adult Crop    91.3 Adult Midgut no informative data Adult Hindgut    63.2 Adult Malpighian Tubules    3.6 Adult Fat Body no informative data Adult Salivary Gland    8.9 Adult Heart    6.275 Adult VirginFemale Spermatheca no informative data Adult InseminatedFemale Spermatheca no informative data Adult Ovary    2.4 Adult Testis    2 Adult Male Accessory Gland    3.8 Adult Carcass    22.2 Expression Level Scale  None   Low   Moderate  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    54.7 Larval Midgut no informative data Larval Hindgut    103.5 Larval Malpighian Tubules    2.9 Larval Fat Body    4.8 Larval Salivary Gland no informative data Larval Trachea    393.425 Larval Carcass    136.55 Adult Head    32.4 Adult Eye    58.05 Adult Brain    5.1 Adult Thoracic-Abdominal Ganglion    6.8 Adult Crop    91.3 Adult Midgut no informative data Adult Hindgut    63.2 Adult Malpighian Tubules    3.6 Adult Fat Body no informative data Adult Salivary Gland    8.9 Adult Heart    6.275 Adult VirginFemale Spermatheca no informative data Adult InseminatedFemale Spermatheca no informative data Adult Ovary    2.4 Adult Testis    2 Adult Male Accessory Gland    3.8 Adult Carcass    22.2 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    54.7 Larval Midgut no informative data Larval Hindgut    103.5 Larval Malpighian Tubules    2.9 Larval Fat Body    4.8 Larval Salivary Gland no informative data Larval Trachea    393.425 Larval Carcass    136.55 Adult Head    32.4 Adult Eye    58.05 Adult Brain    5.1 Adult Thoracic-Abdominal Ganglion    6.8 Adult Crop    91.3 Adult Midgut no informative data Adult Hindgut    63.2 Adult Malpighian Tubules    3.6 Adult Fat Body no informative data Adult Salivary Gland    8.9 Adult Heart    6.275 Adult VirginFemale Spermatheca no informative data Adult InseminatedFemale Spermatheca no informative data Adult Ovary    2.4 Adult Testis    2 Adult Male Accessory Gland    3.8 Adult Carcass    22.2 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    54.7 Larval Midgut no informative data Larval Hindgut    103.5 Larval Malpighian Tubules    2.9 Larval Fat Body    4.8 Larval Salivary Gland no informative data Larval Trachea    393.425 Larval Carcass    136.55 Adult Head    32.4 Adult Eye    58.05 Adult Brain    5.1 Adult Thoracic-Abdominal Ganglion    6.8 Adult Crop    91.3 Adult Midgut no informative data Adult Hindgut    63.2 Adult Malpighian Tubules    3.6 Adult Fat Body no informative data Adult Salivary Gland    8.9 Adult Heart    6.275 Adult VirginFemale Spermatheca no informative data Adult InseminatedFemale Spermatheca no informative data Adult Ovary    2.4 Adult Testis    2 Adult Male Accessory Gland    3.8 Adult Carcass    22.2 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to maximum FBgn0261277 expression level Tissue   Expression Level Larval Central Nervous System    54.7 Larval Midgut no informative data Larval Hindgut    103.5 Larval Malpighian Tubules    2.9 Larval Fat Body    4.8 Larval Salivary Gland no informative data Larval Trachea    393.425 Larval Carcass    136.55 Adult Head    32.4 Adult Eye    58.05 Adult Brain    5.1 Adult Thoracic-Abdominal Ganglion    6.8 Adult Crop    91.3 Adult Midgut no informative data Adult Hindgut    63.2 Adult Malpighian Tubules    3.6 Adult Fat Body no informative data Adult Salivary Gland    8.9 Adult Heart    6.275 Adult VirginFemale Spermatheca no informative data Adult InseminatedFemale Spermatheca no informative data Adult Ovary    2.4 Adult Testis    2 Adult Male Accessory Gland    3.8 Adult Carcass    22.2 Expression Level Scale  None   Low   Moderate   High  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    54.7 Larval Midgut no informative data Larval Hindgut    103.5 Larval Malpighian Tubules    2.9 Larval Fat Body    4.8 Larval Salivary Gland no informative data Larval Trachea    393.425 Larval Carcass    136.55 Adult Head    32.4 Adult Eye    58.05 Adult Brain    5.1 Adult Thoracic-Abdominal Ganglion    6.8 Adult Crop    91.3 Adult Midgut no informative data Adult Hindgut    63.2 Adult Malpighian Tubules    3.6 Adult Fat Body no informative data Adult Salivary Gland    8.9 Adult Heart    6.275 Adult VirginFemale Spermatheca no informative data Adult InseminatedFemale Spermatheca no informative data Adult Ovary    2.4 Adult Testis    2 Adult Male Accessory Gland    3.8 Adult Carcass    22.2 Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    54.7 Larval Midgut no informative data Larval Hindgut    103.5 Larval Malpighian Tubules    2.9 Larval Fat Body    4.8 Larval Salivary Gland no informative data Larval Trachea    393.425 Larval Carcass    136.55 Adult Head    32.4 Adult Eye    58.05 Adult Brain    5.1 Adult Thoracic-Abdominal Ganglion    6.8 Adult Crop    91.3 Adult Midgut no informative data Adult Hindgut    63.2 Adult Malpighian Tubules    3.6 Adult Fat Body no informative data Adult Salivary Gland    8.9 Adult Heart    6.275 Adult VirginFemale Spermatheca no informative data Adult InseminatedFemale Spermatheca no informative data Adult Ovary    2.4 Adult Testis    2 Adult Male Accessory Gland    3.8 Adult Carcass    22.2 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    54.7 Larval Midgut no informative data Larval Hindgut    103.5 Larval Malpighian Tubules    2.9 Larval Fat Body    4.8 Larval Salivary Gland no informative data Larval Trachea    393.425 Larval Carcass    136.55 Adult Head    32.4 Adult Eye    58.05 Adult Brain    5.1 Adult Thoracic-Abdominal Ganglion    6.8 Adult Crop    91.3 Adult Midgut no informative data Adult Hindgut    63.2 Adult Malpighian Tubules    3.6 Adult Fat Body no informative data Adult Salivary Gland    8.9 Adult Heart    6.275 Adult VirginFemale Spermatheca no informative data Adult InseminatedFemale Spermatheca no informative data Adult Ovary    2.4 Adult Testis    2 Adult Male Accessory Gland    3.8 Adult Carcass    22.2 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut no informative data Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland no informative data Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut no informative data Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body no informative data Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca no informative data Adult InseminatedFemale Spermatheca no informative data Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    32.4   NA  Eye    58.05   NA  Brain    5.1   54.7  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    6.8   NA  Crop    91.3   no informative data  Midgut    no informative data   103.5  Hindgut    63.2   2.9  Malpighian Tubules    3.6   4.8  Fat Body    no informative data   no informative data  Salivary Gland    8.9   NA  Heart    6.275   393.425  Trachea    NA   NA  VirginFemale Spermatheca    no informative data   NA  InseminatedFemale Spermatheca    no informative data   NA  Ovary    2.4   NA  Testis    2   NA  Male Accessory Gland    3.8   136.55  Carcass    22.2 modENCODE Temporal Expression Data (Graveley et al., 2011) FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
Expression Clusters
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0261277
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele lethal rtv1 rtv8 rtv9 rtv10 rtv14 lethal | embryonic stage rtv6 lethal | embryonic stage | recessive rtv1 rtv6 rtv11 lethal | larval stage rtv8 lethal | recessive rtv1 rtv9 rtv10 rtv14 semi-lethal | pupal stage, with Scer\GAL4pnr-MD237 rtvGD3309 Phenotype manifest in Allele cephalopharyngeal skeleton rtv1 rtv11 denticle belt rtv11 dorsal trunk primordium rtv11 embryo rtv11 embryonic/first instar larval cuticle rtv11 embryonic/larval dorsal trunk | embryonic stage 15 rtv11 embryonic/larval dorsal trunk | embryonic stage 16 rtv11 embryonic/larval tracheal system rtv11 epicuticle rtv11 presumptive embryonic/larval tracheal system rtv11 procuticle rtv11
Classical Alleles ( 16 )
For All Classical Alleles Show
Allele of rtv Class Mutagen Stocks Known lesion rtv11 amorphic allele - genetic evidence ethyl methanesulfonate 1 Yes rtv10 MR 1 -- rtv8 ethyl methanesulfonate 1 -- rtvG17427 P-element activity 1 -- rtv12 ethyl methanesulfonate 0 -- rtv13 ethyl methanesulfonate 0 -- rtv14 ethyl methanesulfonate 0 -- rtv1 X ray 0 -- rtv2 X ray 0 -- rtv3 X ray 0 -- rtv4 X ray 0 -- rtv5 ethyl methanesulfonate 0 -- rtv6 ethyl methanesulfonate 0 -- rtv7 ethyl methanesulfonate 0 -- rtv9 ethyl methanesulfonate 0 -- rtvBNd ethyl methanesulfonate 0 Yes
Alleles Carried on Transgenic Constructs ( 1 )
For All Alleles Carried on Transgenic Constructs Show
Allele of rtv Class Mutagen Stocks Known lesion rtvGD3309 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes
Aneuploid Aberrations
Duplicated in	Dp(1;2)v+63i (Zhimulev et al., 1981, Zhimulev, 1982, Wieschaus et al., 1984, Eeken et al., 1985, Zhimulev et al., 1987) Dp(1;2)v+65b (Geer et al., 1983, Wieschaus et al., 1984, Eeken et al., 1985, Zhimulev et al., 1987) Dp(1;2)v+75d (Geer et al., 1983, Wieschaus et al., 1984, Eeken et al., 1985) Dp(1;3)DC235 (Popodi et al., 2010-) Dp(1;3)v+74c (Eeken et al., 1985) Dp(1;Y)v+y+ (Zhimulev et al., 1981, Geer et al., 1983, Zhimulev et al., 1987) Dp(1;Y)v+y+366 (Zhimulev et al., 1987) Dp(1;Y)y+v+#3 (Wieschaus et al., 1984, Eeken et al., 1985)
Disrupted in	Df(1)RA37 (Zhimulev et al., 1981, Zhimulev et al., 1987, Tearle and Nusslein-Volhard, 1987) Df(1)v65b (Zhimulev et al., 1981) Df(1)v-N48 (Harbecke and Lengyel, 1995)
Not disrupted in	Df(1)59D3 (Zhimulev et al., 1987) Df(1)203C10 (Zhimulev et al., 1987) Df(1)ct-J4 (Wieschaus et al., 1984) Df(1)GA112 (Tearle and Nusslein-Volhard, 1987, Moussian et al., 2005) Df(1)HA85 (Wieschaus et al., 1984) Df(1)HC133 (Zhimulev et al., 1981, Wieschaus et al., 1984, Zhimulev et al., 1987) Df(1)HF368 (Eeken et al., 1985) Df(1)KA7 (Zhimulev et al., 1981, Geer et al., 1983, Zhimulev et al., 1987, Moussian et al., 2005) Df(1)m259-4 (Eeken et al., 1985) Df(1)N71 (Zhimulev et al., 1981, Geer et al., 1983, Eeken et al., 1985, Zhimulev et al., 1987) Df(1)ras-P14 (Zhimulev et al., 1981, Zhimulev et al., 1987) Df(1)ras-v17 (Zhimulev et al., 1981, Zhimulev et al., 1987) Df(1)ras-v-P26 (Zhimulev et al., 1987) Df(1)sbr1 (Zhimulev et al., 1981, Zhimulev et al., 1987) Df(1)sbr8 (Zhimulev et al., 1981, Zhimulev et al., 1987) Df(1)sbr9 (Zhimulev et al., 1981, Zhimulev et al., 1987) Df(1)sbr10 (Zhimulev et al., 1981, Zhimulev et al., 1987) Df(1)v64f (Zhimulev et al., 1981, Zhimulev et al., 1987) Df(1)v-B151 (Zhimulev et al., 1987) Df(1)v-L1 (Zhimulev et al., 1981, Geer et al., 1983, Zhimulev et al., 1987) Df(1)v-L2 (Zhimulev et al., 1981, Geer et al., 1983, Zhimulev et al., 1987) Df(1)v-L3 (Zhimulev et al., 1981, Geer et al., 1983, Wieschaus et al., 1984, Eeken et al., 1985, Zhimulev et al., 1987) Df(1)v-L4 (Zhimulev et al., 1981, Geer et al., 1983, Eeken et al., 1985, Zhimulev et al., 1987) Df(1)v-L7 (Zhimulev et al., 1981, Zhimulev et al., 1987) Df(1)v-L11 (Zhimulev et al., 1981, Zhimulev et al., 1987) Df(1)v-L15 (Zhimulev et al., 1981, Eeken et al., 1985, Zhimulev et al., 1987) Df(1)v-M1 (Zhimulev et al., 1981, Zhimulev et al., 1987) Df(1)v-M5 (Zhimulev et al., 1981, Zhimulev et al., 1987) Df(1)v-M6 (Zhimulev et al., 1981, Zhimulev et al., 1987) Df(1)v-M7 (Zhimulev et al., 1981, Zhimulev et al., 1987) Df(1)v-P5 (Zhimulev et al., 1981, Zhimulev et al., 1987) Df(1)v-P16 (Zhimulev et al., 1987) Df(1)v-P22 (Zhimulev et al., 1987)
Not duplicated in	Dp(1;Y)dsh+y+ (Zhimulev et al., 1987) Dp(1;Y)v+y+U15 (Zhimulev et al., 1987)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data
Insertions
	Type of insertions Name Expression data insertion of mobile activating element P{EP}rtvG17427 NA
Gene Ontology: Function, Process & Cellular Component ( 5 unique terms )
Terms Based on Experimental Evidence ( 5 terms )
Molecular Function ( 0 terms)
Biological Process
CV term Evidence References
chitin-based embryonic cuticle biosynthetic process inferred from mutant phenotype (Ostrowski et al., 2002) chitin biosynthetic process inferred from mutant phenotype (Moussian et al., 2006) open tracheal system development inferred from mutant phenotype (Moussian et al., 2006) regulation of tube architecture, open tracheal system inferred from mutant phenotype (Moussian et al., 2006) regulation of tube diameter, open tracheal system inferred from mutant phenotype (Moussian et al., 2006)
Cellular Component ( 0 terms)
Terms Based on Predictions or Assertions ( 0 terms )
Sequence Ontology: Class of Gene
	gene   nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Protein-protein
Interacting group Assay References
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions rtv allele Gene References
External Data
Linkouts	DroID - A comprehensive database of gene and protein interactions. • FBgn0261277
Orthologs
Genome-wide drosophilid orthologs	Dana\GF22363 Dere\GG18875 Dmoj\GI15764 Dper\GL20306 Dpse\GA12667 Dsec\GM11260 Dsim\GD24538 Dvir\GJ18621 Dwil\GK18863 Dyak\GE17315
Curated drosophilid orthologs	Dpse\GA12667
Linkouts	InParanoid A subset of ortholog calls from InParanoid. • AAEL002438-PA Aedes aegypti (mosquito) AGAP011412-PA Anopheles gambiae (mosquito) XP_001948868.1 Acyrthosiphon pisum (pea aphid) BGIBMGA000996-PA Bombyx mori (silk worm) CPIJ012785 Culex pipens (mosquito) 307452 Daphnia pulex (daphnia) 176884 Hypsipyla robusta (cedar shoot borer) XP_001605396.1 Nasonia vitripennis (wasp) PHUM003897-PA Pediculus humanus (human body louse) OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • NV14436 LH19027 ISCW004015 FBgn0234788 FBgn0220861 FBgn0205777 FBgn0195872 FBgn0166205 JGI_V11_307452 FBgn0072713 FBgn0157901 FBgn0138513 FBgn0119709 FBgn0119249 FBgn0111082 FBgn0099359 CPIJ012785 BGIBMGA000996 ACYPI009796 GB11601 AGAP011412 AAEL002438 PB26057 PHUM085720 GLEAN_07384
Stocks & Reagents
Stocks Listed in FlyBase ( 5 )
Bloomington	3297 w* rtv11/FM7c 26635 w* P{EP}rtvG17427/FM6, w* 4694 y1 sc1 lz9 rtv8/FM7a 5672 y1 mei-9a rtv10 mei-41D5/FM7c
VDRC	v5538 w1118; P{GD3309}v5538/TM3
Genomic Clones ( 1 )
	BACR26J12 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 5 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	LD10746
Other clones
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	RE63055
Other clones	161334 ESG0119a.B21_H12 UT01167
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0261277 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 32056 44022
Antibody Information
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of
Source for database merge of	Source for merge of: rtv CG1397 (Moussian et al., 2005)
Additional comments	Allelism with Lefevre lethals reported by Perrimon, Engstrom and Mahowald, 1989.
Other Comments
	knk is required for chitin filament assembly in the tracheal lumen and cuticle. (Moussian et al., 2006) rtv mutants display darkly sclerotinized mouth parts. (Wieschaus et al., 1984)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_132465 RefSeq (Proteins) • NP_572693 DDBJ / EMBL / GenBank • AA391822 AAF48010 AAL28674 AW942152 AY061126 Entrez Gene - A searchable database of RefSeq genes. • 32056 UniProtKB/TrEMBL • Q9VZ21
Other Crossreferences
Linkouts
	DroID - A comprehensive database of gene and protein interactions. • FBgn0261277 DRSC - Results from RNAi screens. • FBgn0261277 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0261277 FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0261277 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 32056 44022 InParanoid A subset of ortholog calls from InParanoid. • AAEL002438-PA Aedes aegypti (mosquito) AGAP011412-PA Anopheles gambiae (mosquito) XP_001948868.1 Acyrthosiphon pisum (pea aphid) BGIBMGA000996-PA Bombyx mori (silk worm) CPIJ012785 Culex pipens (mosquito) 307452 Daphnia pulex (daphnia) 176884 Hypsipyla robusta (cedar shoot borer) XP_001605396.1 Nasonia vitripennis (wasp) PHUM003897-PA Pediculus humanus (human body louse) modMine - Data generated by the modENCODE project. • FBgn0261277 OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • NV14436 LH19027 ISCW004015 FBgn0234788 FBgn0220861 FBgn0205777 FBgn0195872 FBgn0166205 JGI_V11_307452 FBgn0072713 FBgn0157901 FBgn0138513 FBgn0119709 FBgn0119249 FBgn0111082 FBgn0099359 CPIJ012785 BGIBMGA000996 ACYPI009796 GB11601 AGAP011412 AAEL002438 PB26057 PHUM085720 GLEAN_07384
Synonyms & Secondary IDs ( 8 )
Reported As
Symbol Synonym	1 (Lefevre and Watkins, 1986, Lefevre, 1981) CG1397 (Hijazi et al., 2009, Moussian et al., 2005, Babenko et al., 2009) L1 (Eeken et al., 1985) l(1)10Ag   l(1)G13   l(1)L1 (Zhimulev et al., 1987, Zhimulev, 1982, Zhimulev et al., 1981) rtv (Hijazi et al., 2009, Moussian et al., 2005, Popodi et al., 2010-)
Name Synonym	CG1397   retroactive (Moussian et al., 2005)
Secondary FlyBase IDs
	FBgn0001487 FBgn0003294 FBgn0005400 FBgn0030275
References ( 25 )
Generate a list of	All references relating to this gene ( 25 )
List References by type	Research paper  ( 18 ) Supplementary material  ( 1 ) Personal communication to FlyBase  ( 3 ) Stock list  ( 1 ) Book  ( 1 ) Computer file  ( 1 )
Recent research papers (0)
	All research papers listed in FlyBase were published before 2010 Show research papers ...