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Gene Dmel\grp

General Information
Symbol	Dmel\grp	Species	D. melanogaster
Name	grapes	Annotation symbol	CG17161
Feature type	protein_coding_gene	FlyBase ID	FBgn0261278
Gene Model Status	Current	Stock availability	40 publicly available
Also Known As	Chk1, dChk1, lemp
Genomic Location
Chromosome (arm)	2L	Recombination map
Cytogenetic map	36A10-36A11	Sequence location	2L:16,680,046..16,699,930 [+]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents modENCODE GBrowse	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene grapes is referred to in FlyBase by the symbol Dmel\grp (CG17161, FBgn0261278). It is a protein_coding_gene from Drosophila melanogaster. Based on sequence similarity, it is predicted to have molecular function: protein kinase activity; protein serine/threonine kinase activity. There is experimental evidence that it is involved in the biological process: female meiosis chromosome segregation; centrosome separation; cell cycle arrest; mitotic cell cycle G2/M transition DNA damage checkpoint; regulation of syncytial blastoderm mitotic cell cycle; spindle assembly; cell cycle; DNA damage checkpoint. 97 alleles are reported. The phenotypes of these alleles are annotated with: multicellular structure; anatomical structure; cleavage stage embryo; sense organ; eo support cell; syncytial blastoderm embryo; organelle; cell cluster organ; blastoderm embryo; cell part; intracellular organelle part. It has 4 annotated transcripts and 4 annotated polypeptides. Protein features are: Protein kinase, ATP binding site; Protein kinase, catalytic domain; Protein kinase-like domain; Serine/threonine-protein kinase, active site; Serine/threonine-protein kinase, catalytic domain; Serine/threonine-protein kinase-like domain. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of very high expression to a trough of moderate expression. Peak expression observed within 00-06 hour embryonic stages. Summary of FlyAtlas Anatomical Expression Data: Two or more Affy2 ProbeSets identify exons of this gene. This is a summary of the tissue expression peaks exhibited in at least one of these ProbeSets. Expression in all larval and adult organs/tissues ranges from low to undetected. Expression at high levels in the following post-embryonic organs or tissues: larval/adult central nervous system, larval salivary gland, adult ovary. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, adult eye, adult crop, larval/adult midgut, larval/adult hindgut, larval/adult Malpighian tubules, larval fat body, adult salivary gland, larval trachea, adult spermathecae, adult testis, larval carcass. Gene sequence location is 2L:16680046..16699930.
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2012_01	References Reis et al., 2010, PLoS Genet. 6(11): e1001206 Yi et al., 2009, Mol. Biol. Cell 20(3): 983--994 Sequence features BKN28548 BKN51319 BKN51217
FB2011_10
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 36A10-36A11   Left limit from in situ hybridisation (FBrf0067338) Right limit from in situ hybridisation (FBrf0067338)
Experimentally Determined Cytological Location
Cytogenetic map Notes References 36A10-36A10   (determined by in situ hybridisation)   (Abdelilah-Seyfried et al., 2000) 36A10-36A10   (determined by in situ hybridisation)   (Spradling et al., 1999) 36A-36B   (determined by in situ hybridisation)   (Sibon et al., 1997) 36A10-36A14   (determined by in situ hybridisation)   (Fogarty et al., 1997) 36A10-36A11     (BDGP Project Members, 1994-1999) 36A-36B   (determined by in situ hybridisation)   (Sullivan et al., 1993) 36A-36A   (determined by in situ hybridisation)   (Kalderon and Rubin, 1988)
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\grp for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) grp-RA FBtr0080886  NM_057663   2776   512 grp-RB FBtr0080884  NM_165171   2242   512 grp-RC FBtr0080885  NM_165172   2352   512 grp-RD FBtr0100459  NM_165173   1655   398
Additional Transcript Data & Comments
Reported size (kB)	2.5, 2.0 (northern blot) (Fogarty et al., 1997)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein grp-PA   FBpp0080443   57.8   512   8.20     NP_477011   AAF53552 grp-PB   FBpp0080441   57.8   512   8.20     NP_723985   AAN10952 grp-PC   FBpp0080442   57.8   512   8.20     NP_723986   AAF53551 grp-PD   FBpp0099886   45.3   398   8.54     NP_723987   AAN10953
Additional Polypeptide Data & Comments
Reported size (kDa)	513 (aa) (Fogarty et al., 1997)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Protein kinase, catalytic domain (IPR000719) Serine/threonine-protein kinase, catalytic domain (IPR002290) Serine/threonine-protein kinase, active site (IPR008271) Protein kinase-like domain (IPR011009) Protein kinase, ATP binding site (IPR017441) Serine/threonine-protein kinase-like domain (IPR017442)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA141959   AA141960   AA390988   AA440223   AA540920   AA941720   AA942557   AA942645   AE014134 AAF53551   AE014134 AAF53552   AE014134 AAN10952   AE014134 AAN10953   AC005133   AC006214   AF057041 AAC13566   AI257108   AI516426   AI516821   AI518967   AI519800   AI944721   AQ024960   AQ024988   AQ025028   AQ026086   AQ073387   AQ073508   AQ073692   AQ073724   AQ073736   AW943628   AY051961 AAK93385   AZ300924   BF490777   BF499688   BF501077   BF503388   BG638076   BI162963   BI171951   BI172868   BI212928   BI216522   BI228968   BI231870   BI234461   BI237298   BI238402   BI239741   BI240209   BI240426   BI243457   BI243713   BI243882   BI356196   BI357465   BI361474   BI361479   BI362925   BI363877   BI365098   BI366554   BI369248   BI372574   BI373726   BI375550   BI481971   BI483365   BI483794   BI486177   BI486259   BI486914   BI582504   BI632545   BP555420   BP555421   BT126031   BZ286410   CL526126   CL943523   CO185419   CO264230   CO264908   CO265932   CO283445   CO299300   CO308637   CO332007   CZ467001   CZ467018   CZ469594   CZ469595   CZ470220   CZ473024   CZ475799   CZ477991   CZ480020   CZ485912   CZ486156   CZ489622   CZ489623   EC052491   EC052494   EC053039   EC055373   EC055785   EC084269   EC090510   EC195095   EC199534   EC228875   EC232981   EC249595   EC255437   EV578653   EV582346   EV583391   EV599409   GH751978   GH755609   GH775832   GH798796   GH816187   GH842209   GH844227   GH852665   GH889627   GH894705   GH913662   GH933937   GH942055   GH944818   GH945632   GH947910   GH948101   GH950177   GH950385   GH951216   GH951284   GH951411   GH954076   GH960926   GH962915   GH963060   GH963092   GH965756   GH965823   GH966444   GH967192   GH967242   GH974368   GH979470   GH979833   GH980988   GH982452   GH984034
UniProtKB/Swiss-Prot	O61661
UniProtKB/TrEMBL
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
in situ Stage Tissue/Position (including subcellular localization) Reference embryonic stage 4   organism   • yolk plasma | posterior (Lecuyer et al., 2007) embryonic stage 5   pole cell   (Lecuyer et al., 2007) northern blot Stage Tissue/Position (including subcellular localization) Reference embryonic stage     (Fogarty et al., 1997) embryonic stage -- adult stage     (Fogarty et al., 1997) adult stage & oogenesis   oocyte   (Fogarty et al., 1997)
Additional Descriptive Data
	grp transcripts are detected at high levels in the oocyte and in early embryogenesis (abundant and homogeneous in the first 12 nuclear cycles), decline until cellularization, and remain at low levels in late embryogenesis and in larval stages. Levels are higher in pupariation. The transcript is abundant in adult females but not in adult males. (Fogarty et al., 1997)
Marker for
Subcellular Localization
CV Term
Notes
Polypeptide Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
High-Throughput Expression Data
or
See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes. modENCODE Temporal Expression Data for FBgn0261278    Styles Linear Logarithmic Heatmap    Scales max expr for FBgn0261278 Very low expression bin max Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of very high expression to a trough of moderate expression. Peak expression observed within 00-06 hour embryonic stages. [download data (TSV)] Guide to modENCODE expression level colors   No expression (0 - 0)   Extremely low expression (1 - 10)   Very low expression (11 - 100)   Low expression (101 - 400)   Moderate expression (401 - 1400)   Moderately high expression (1401 - 4000)   High expression (4001 - 10000)   Very high expression (10001 - 100000)   Extremely high expression (100001 - 2000000) Linear, scaled to maximum FBgn0261278 expression level Developmental Stage   Expression Level embryo 00-02hr    12532 embryo 02-04hr    4660 embryo 04-06hr    4630 embryo 06-08hr    3334 embryo 08-10hr    2252 embryo 10-12hr    2001 embryo 12-14hr    1224 embryo 14-16hr    1260 embryo 16-18hr    904 embryo 18-20hr    782 embryo 20-22hr    1057 embryo 22-24hr    1084 larva L1    1524 larva L2    1138 larva L3 12hr old    817 larva L3 puffstage 1-2    1506 larva L3 puffstage 3-6    2324 larva L3 puffstage 7-9    3314 white prepupae new    3758 white prepupae 12hr    5086 white prepupae 24hr    6039 pupae 2d postWPP    3553 pupae 3d postWPP    714 pupae 4d postWPP    707 adult male 01day    626 adult male 05day    839 adult male 30day    851 adult female 01day    4029 adult female 05day    7507 adult female 30day    7884 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (12532) embryo 02-04hr  (4660) embryo 04-06hr  (4630) embryo 06-08hr  (3334) embryo 08-10hr  (2252) embryo 10-12hr  (2001) embryo 12-14hr  (1224) embryo 14-16hr  (1260) embryo 16-18hr  (904) embryo 18-20hr  (782) embryo 20-22hr  (1057) embryo 22-24hr  (1084) larva L1  (1524) larva L2  (1138) larva L3 12hr old  (817) larva L3 puffstage 1-2  (1506) larva L3 puffstage 3-6  (2324) larva L3 puffstage 7-9  (3314) white prepupae new  (3758) white prepupae 12hr  (5086) white prepupae 24hr  (6039) pupae 2d postWPP  (3553) pupae 3d postWPP  (714) pupae 4d postWPP  (707) adult male 01day  (626) adult male 05day  (839) adult male 30day  (851) adult female 01day  (4029) adult female 05day  (7507) adult female 30day  (7884) Expression Level Scale  None   Extremely low   Very low   Low  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (12532) embryo 02-04hr  (4660) embryo 04-06hr  (4630) embryo 06-08hr  (3334) embryo 08-10hr  (2252) embryo 10-12hr  (2001) embryo 12-14hr    1224 embryo 14-16hr    1260 embryo 16-18hr    904 embryo 18-20hr    782 embryo 20-22hr    1057 embryo 22-24hr    1084 larva L1  (1524) larva L2    1138 larva L3 12hr old    817 larva L3 puffstage 1-2  1506 larva L3 puffstage 3-6  (2324) larva L3 puffstage 7-9  (3314) white prepupae new  (3758) white prepupae 12hr  (5086) white prepupae 24hr  (6039) pupae 2d postWPP  (3553) pupae 3d postWPP    714 pupae 4d postWPP    707 adult male 01day    626 adult male 05day    839 adult male 30day    851 adult female 01day  (4029) adult female 05day  (7507) adult female 30day  (7884) Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr  (12532) embryo 02-04hr    4660 embryo 04-06hr    4630 embryo 06-08hr    3334 embryo 08-10hr    2252 embryo 10-12hr    2001 embryo 12-14hr    1224 embryo 14-16hr    1260 embryo 16-18hr    904 embryo 18-20hr    782 embryo 20-22hr    1057 embryo 22-24hr    1084 larva L1    1524 larva L2    1138 larva L3 12hr old    817 larva L3 puffstage 1-2    1506 larva L3 puffstage 3-6    2324 larva L3 puffstage 7-9    3314 white prepupae new    3758 white prepupae 12hr    5086 white prepupae 24hr    6039 pupae 2d postWPP    3553 pupae 3d postWPP    714 pupae 4d postWPP    707 adult male 01day    626 adult male 05day    839 adult male 30day    851 adult female 01day    4029 adult female 05day    7507 adult female 30day    7884 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    12532 embryo 02-04hr    4660 embryo 04-06hr    4630 embryo 06-08hr    3334 embryo 08-10hr    2252 embryo 10-12hr    2001 embryo 12-14hr    1224 embryo 14-16hr    1260 embryo 16-18hr    904 embryo 18-20hr    782 embryo 20-22hr    1057 embryo 22-24hr    1084 larva L1    1524 larva L2    1138 larva L3 12hr old    817 larva L3 puffstage 1-2    1506 larva L3 puffstage 3-6    2324 larva L3 puffstage 7-9    3314 white prepupae new    3758 white prepupae 12hr    5086 white prepupae 24hr    6039 pupae 2d postWPP    3553 pupae 3d postWPP    714 pupae 4d postWPP    707 adult male 01day    626 adult male 05day    839 adult male 30day    851 adult female 01day    4029 adult female 05day    7507 adult female 30day    7884 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  log, scaled to maximum FBgn0261278 expression level Developmental Stage   Expression Level embryo 00-02hr    12532 embryo 02-04hr    4660 embryo 04-06hr    4630 embryo 06-08hr    3334 embryo 08-10hr    2252 embryo 10-12hr    2001 embryo 12-14hr    1224 embryo 14-16hr    1260 embryo 16-18hr    904 embryo 18-20hr    782 embryo 20-22hr    1057 embryo 22-24hr    1084 larva L1    1524 larva L2    1138 larva L3 12hr old    817 larva L3 puffstage 1-2    1506 larva L3 puffstage 3-6    2324 larva L3 puffstage 7-9    3314 white prepupae new    3758 white prepupae 12hr    5086 white prepupae 24hr    6039 pupae 2d postWPP    3553 pupae 3d postWPP    714 pupae 4d postWPP    707 adult male 01day    626 adult male 05day    839 adult male 30day    851 adult female 01day    4029 adult female 05day    7507 adult female 30day    7884 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (12532) embryo 02-04hr  (4660) embryo 04-06hr  (4630) embryo 06-08hr  (3334) embryo 08-10hr  (2252) embryo 10-12hr  (2001) embryo 12-14hr  (1224) embryo 14-16hr  (1260) embryo 16-18hr  (904) embryo 18-20hr  (782) embryo 20-22hr  (1057) embryo 22-24hr  (1084) larva L1  (1524) larva L2  (1138) larva L3 12hr old  (817) larva L3 puffstage 1-2  (1506) larva L3 puffstage 3-6  (2324) larva L3 puffstage 7-9  (3314) white prepupae new  (3758) white prepupae 12hr  (5086) white prepupae 24hr  (6039) pupae 2d postWPP  (3553) pupae 3d postWPP  (714) pupae 4d postWPP  (707) adult male 01day  (626) adult male 05day  (839) adult male 30day  (851) adult female 01day  (4029) adult female 05day  (7507) adult female 30day  (7884) Expression Level Scale  None   Extremely low   Very low   Low  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (12532) embryo 02-04hr  (4660) embryo 04-06hr  (4630) embryo 06-08hr  (3334) embryo 08-10hr  2252 embryo 10-12hr  2001 embryo 12-14hr    1224 embryo 14-16hr    1260 embryo 16-18hr    904 embryo 18-20hr    782 embryo 20-22hr    1057 embryo 22-24hr    1084 larva L1  1524 larva L2    1138 larva L3 12hr old    817 larva L3 puffstage 1-2  1506 larva L3 puffstage 3-6  2324 larva L3 puffstage 7-9  (3314) white prepupae new  (3758) white prepupae 12hr  (5086) white prepupae 24hr  (6039) pupae 2d postWPP  (3553) pupae 3d postWPP    714 pupae 4d postWPP    707 adult male 01day    626 adult male 05day    839 adult male 30day    851 adult female 01day  (4029) adult female 05day  (7507) adult female 30day  (7884) Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr  12532 embryo 02-04hr    4660 embryo 04-06hr    4630 embryo 06-08hr    3334 embryo 08-10hr    2252 embryo 10-12hr    2001 embryo 12-14hr    1224 embryo 14-16hr    1260 embryo 16-18hr    904 embryo 18-20hr    782 embryo 20-22hr    1057 embryo 22-24hr    1084 larva L1    1524 larva L2    1138 larva L3 12hr old    817 larva L3 puffstage 1-2    1506 larva L3 puffstage 3-6    2324 larva L3 puffstage 7-9    3314 white prepupae new    3758 white prepupae 12hr    5086 white prepupae 24hr    6039 pupae 2d postWPP    3553 pupae 3d postWPP    714 pupae 4d postWPP    707 adult male 01day    626 adult male 05day    839 adult male 30day    851 adult female 01day    4029 adult female 05day    7507 adult female 30day    7884 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    12532 embryo 02-04hr    4660 embryo 04-06hr    4630 embryo 06-08hr    3334 embryo 08-10hr    2252 embryo 10-12hr    2001 embryo 12-14hr    1224 embryo 14-16hr    1260 embryo 16-18hr    904 embryo 18-20hr    782 embryo 20-22hr    1057 embryo 22-24hr    1084 larva L1    1524 larva L2    1138 larva L3 12hr old    817 larva L3 puffstage 1-2    1506 larva L3 puffstage 3-6    2324 larva L3 puffstage 7-9    3314 white prepupae new    3758 white prepupae 12hr    5086 white prepupae 24hr    6039 pupae 2d postWPP    3553 pupae 3d postWPP    714 pupae 4d postWPP    707 adult male 01day    626 adult male 05day    839 adult male 30day    851 adult female 01day    4029 adult female 05day    7507 adult female 30day    7884 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     FlyAtlas Anatomical Expression Data for FBgn0261278    Styles Linear Logarithmic Heatmap Back-to-back    Scales max expr for FBgn0261278 Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Two or more Affy2 ProbeSets identify exons of this gene. This is a summary of the tissue expression peaks exhibited in at least one of these ProbeSets. Expression in all larval and adult organs/tissues ranges from low to undetected. Expression at high levels in the following post-embryonic organs or tissues: larval/adult central nervous system, larval salivary gland, adult ovary. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, adult eye, adult crop, larval/adult midgut, larval/adult hindgut, larval/adult Malpighian tubules, larval fat body, adult salivary gland, larval trachea, adult spermathecae, adult testis, larval carcass. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (1000 - 25000) Heatmap Tissue   Expression Level Larval Central Nervous System no informative data Larval Midgut no informative data Larval Hindgut no informative data Larval Malpighian Tubules no informative data Larval Fat Body no informative data Larval Salivary Gland no informative data Larval Trachea no informative data Larval Carcass no informative data Adult Head no informative data Adult Eye no informative data Adult Brain no informative data Adult Thoracic-Abdominal Ganglion no informative data Adult Crop no informative data Adult Midgut no informative data Adult Hindgut no informative data Adult Malpighian Tubules no informative data Adult Fat Body no informative data Adult Salivary Gland no informative data Adult Heart no informative data Adult VirginFemale Spermatheca no informative data Adult InseminatedFemale Spermatheca no informative data Adult Ovary no informative data Adult Testis no informative data Adult Male Accessory Gland no informative data Adult Carcass no informative data modENCODE Temporal Expression Data (Graveley et al., 2011) FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
Expression Clusters
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0261278
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele lethal | embryonic stage | maternal effect grp06034 grpfsA4 grpZ5170 lethal | embryonic stage | maternal effect (with Df(2L)H20) grp209 grp06034 grpZ5170 lethal | embryonic stage | maternal effect (with grp209) grp06034 lethal | embryonic stage | maternal effect (with grp06034) grp209 grpZ5170 lethal | embryonic stage | maternal effect (with grpZ5170) grp06034 lethal | embryonic stage | non-rescuable maternal effect grpfs1 lethal | maternal effect | recessive grp2 grp02257 grp06034 lethal | recessive grp06034 grpk15102 semi-lethal, with Scer\GAL4sca-537.4 grpGS2133 viable grp06034 grpCB04894 grpe00087 grpEY09600 grpEY11888 grpScim viable, with Scer\GAL4pnr-MD237 grpGD4189 Sterility Allele female sterile grp06034 grplemp-8 female sterile | recessive grp02257 grp06034 fertile grp06034 grpe00087 grpEY09600 grpEY11888 Other Phenotypes Allele chemical sensitive grpfsA4 chemical sensitive | recessive grpfsA4 mitotic cell cycle defective grp06034 grpfsA4 radiation resistant grpunspecified radiation sensitive grp06034 radiation sensitive, with Scer\GAL4ap-md544 grpJF02588 visible, with Scer\GAL4GMR.PF grpGS5044 grpScer\UAS.cPa visible, with Scer\GAL4sca-537.4 grpEP587 Phenotype manifest in Allele adult abdomen & macrochaeta, with Scer\GAL4sca-537.4 grpEP587 anaphase & centrosome & syncytial blastoderm embryo grp06034 centrosome grpunspecified centrosome | embryonic stage grpfsA4 cycle 11 embryo grp06034 cycle 11 embryo | maternal effect grp06034 cycle 12 embryo grp06034 grpunspecified cycle 12 embryo | maternal effect grp06034 cycle 13 embryo grp06034 grpunspecified cycle 13 embryo | maternal effect grp06034 cycle 14 embryo | maternal effect grp06034 eye, with Scer\GAL4GMR.PF grpScer\UAS.cPa grpGS5044 interphase & organism | embryonic cycle 11 | maternal effect grpunspecified interphase & organism | embryonic cycle 12 | maternal effect grpunspecified interphase & organism | embryonic cycle 13 | maternal effect grpunspecified macrochaeta grpBG00940 grpBG01786 grpBG02170 grpL36B midbody grpunspecified mitosis & nuclear chromosome grp06034 mitotic cell cycle | embryonic stage grp06034 mitotic metaphase | maternal effect grp06034 mitotic telophase | maternal effect grp06034 spindle grp06034 grpunspecified grpZ5170 spindle (with Df(2L)H20) grp06034 grp209 grpZ5170 spindle | embryonic stage grpfsA4 spindle | embryonic stage 4 grp06034 syncytial blastoderm embryo grpfsA4 grpunspecified tormogen cell, with Scer\GAL4sca-537.4 grpEP587 trichogen cell, with Scer\GAL4sca-537.4 grpEP587
Classical Alleles ( 87 )
For All Classical Alleles Show
Allele of grp Class Mutagen Stocks Known lesion grpe00087 piggyBac transposase 2 -- grpk15102 P-element activity 2 -- grp06034 loss of function allele P-element activity 1 Yes grp5-HA-2006 1 -- grp5-HA-2860 1 -- grpA196 1 -- grpc01254 piggyBac transposase 1 -- grpc04899 piggyBac transposase 1 -- grpCB-0483-3 1 -- grpCB-0581-3 1 -- grpCB-5051-3 1 -- grpCB-5305-3 1 -- grpCB-5471-3 1 -- grpCB-6650-3 1 -- grpd02837 P-element activity 1 -- grpd10141 1 -- grpDG02808 P-element activity 1 -- grpDG25208 P-element activity 1 -- grpe02195 piggyBac transposase 1 -- grpEY00450 P-element activity 1 -- grpf00841 1 -- grpf03358 piggyBac transposase 1 -- grpGS10582 1 -- grpGS6056 1 Yes grpKG08033 1 -- grpMB08323 1 -- grpMI02105 1 -- grpNP0269 1 -- grpNP1225 1 -- grpNP2668 1 -- grpNP3042 1 -- grpNP3606 1 -- grpNP4265 1 -- grpNP4755 1 -- grpNP5294 1 -- grpNP7402 1 -- grp01460 P-element activity 0 -- grp02257 loss of function allele P-element activity 0 Yes grp04144 P-element activity 0 -- grp04701 P-element activity 0 -- grp05812 P-element activity 0 -- grp1034 0 -- grp209 loss of function allele P-element activity 0 Yes grp2 loss of function allele P-element activity 0 Yes grp4 P-element activity 0 Yes grp5-HA-2654 0 -- grpBG00940 P-element activity 0 Yes grpBG01786 P-element activity 0 Yes grpBG02170 P-element activity 0 Yes grpbg57 0 -- grpc01229 piggyBac transposase 0 -- grpc05746 piggyBac transposase 0 -- grpCB-0412-3 0 -- grpCB-0413-3 0 -- grpCB-5812-3 0 -- grpCB04894 P-element activity 0 Yes grpCPTI000640 piggyBac transposase 0 Yes grpd07447 0 -- grpd07543 P-element activity 0 -- grpEP1106 P-element activity 0 -- grpEP2044 P-element activity 0 -- grpEP2196 P-element activity 0 -- grpEP2343 P-element activity 0 -- grpEP2566 P-element activity 0 -- grpEP2610 P-element activity 0 -- grpEP2623 P-element activity 0 -- grpEP587 P-element activity 0 Yes grpEP921 P-element activity 0 Yes grpEY09600 P-element activity 0 -- grpEY11888 P-element activity 0 -- grpf03577 piggyBac transposase 0 -- grpf06887 piggyBac transposase 0 -- grpfs1 0 -- grpfsA4 loss of function allele P-element activity 0 Yes grpGS.M P-element activity 0 Yes grpGS14006 0 -- grpGS2133 0 Yes grpGS5044 0 Yes grpL36B P-element activity 0 -- grplemp-8 X ray 0 -- grplemp-mat-1 spontaneous 0 -- grpNP4260 0 -- grpNP4781 0 -- grpNP4791 0 -- grpScim Delta2-3 0 Yes grpunspecified 0 -- grpZ5170 loss of function allele ethyl methanesulfonate 0 Yes
Alleles Carried on Transgenic Constructs ( 10 )
For All Alleles Carried on Transgenic Constructs Show
Allele of grp Class Mutagen Stocks Known lesion grpGD4189 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes grpJF02588 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes grpD130A.Scer\UAS in vitro construct - amino acid replacement 0 Yes grpdsRNA.cdVa in vitro construct - RNAi 0 Yes grpKK108548 in vitro construct - RNAi in vitro construct - regulatory fusion 0 Yes grplemp-B17 in vitro construct - genomic fragment 0 Yes grplemp-B17dX in vitro construct - deletion 0 Yes grplemp-H10 in vitro construct - genomic fragment 0 Yes grpScer\UAS.cPa in vitro construct - regulatory fusion 0 Yes grpt29.8 in vitro construct - genomic fragment 0 Yes
Aneuploid Aberrations
Disrupted in	Df(2L)cact-255rv64 (Spradling et al., 1999, BDGP Project Members, 1994-1999) Df(2L)Exel7066 (Ryder, 2004.4.26) Df(2L)H10 (Sibon et al., 1997) Df(2L)H20 (Li and Baker, 1998, Spradling et al., 1999, BDGP Project Members, 1994-1999) Df(2L)her8 (Li and Baker, 1998) In(2L)hermat-1 (Li and Baker, 1998)
Not disrupted in	Df(2L)r10 (Spradling et al., 1999, BDGP Project Members, 1994-1999)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD4189} NA P{KK108548} NA P{TRiP.JF02588} NA P{UAS-grp.D130A} NA P{UAS-grp.P} NA characterization construct P{her.B17} NA P{her.H10} NA P{lemp.B17dX} NA
Insertions
	Type of insertions Name Expression data insertion of enhancer trap P{lacW}grpk15102 No P{lacW}l(2)SH1469SH1469 No P{lArB}grpL36B No P{PZ}grp01460 No P{PZ}grp02257 No P{PZ}grp04144 No P{PZ}grp04701 No P{PZ}grp05812 No P{PZ}grp06034 No insertion of mobile activating element P{EP}grpEP587 NA P{EP}grpEP921 NA P{EP}grpEP1106 NA P{EP}grpEP2044 NA P{EP}grpEP2196 NA P{EP}grpEP2343 NA P{EP}grpEP2566 NA P{EP}grpEP2610 NA P{EP}grpEP2623 NA P{EPgy2}grpEY00450 NA P{EPgy2}grpEY09600 NA P{EPgy2}grpEY11888 NA P{GSV1}grpGS2133 NA P{GSV1}GSd306GSd306 NA P{GSV1}GSd445GSd445 NA P{GSV2}grpGS5044 NA P{GSV3}grpGS6056 NA P{GSV6}grpGS10582 NA P{GSV6}grpGS14006 NA P{XP}grpd02837 NA P{XP}grpd07447 NA P{XP}grpd07543 NA P{XP}grpd10141 NA miscellaneous insertions Mi{MIC}grpMI02105 NA P{}grp2 NA P{}grp4 NA P{CaryP}attP14 NA P{GS-un}grpGS.M NA P{GT1}grpBG00940 NA P{GT1}grpBG01786 NA P{GT1}grpBG02170 NA P{hsneo}grpfsA4 NA P{PTT-GB}grpCB04894 NA P{RS3}grpCB-0412-3 NA P{RS3}grpCB-0413-3 NA P{RS3}grpCB-0483-3 NA P{RS3}grpCB-0581-3 NA P{RS3}grpCB-5051-3 NA P{RS3}grpCB-5305-3 NA P{RS3}grpCB-5471-3 NA P{RS3}grpCB-5812-3 NA P{RS3}grpCB-6650-3 NA P{RS5}grp5-HA-2006 NA P{RS5}grp5-HA-2654 NA P{RS5}grp5-HA-2860 NA P{SUPor-P}grpKG08033 NA P{SUPor-P}grpScim NA P{UAS-LUC.M}attP14 NA P{wHy}grpDG02808 NA P{wHy}grpDG25208 NA PBac{5HPw+}grpA196 NA PBac{602.P.SVS-1}grpCPTI000640 NA PBac{PB}grpc01229 NA PBac{PB}grpc01254 NA PBac{PB}grpc04899 NA PBac{PB}grpc05746 NA PBac{RB}grpe00087 NA PBac{RB}grpe02195 NA PBac{WH}grpf00841 NA PBac{WH}grpf03358 NA PBac{WH}grpf03577 NA PBac{WH}grpf06887 NA insertion of enhancer trap binary system Mi{ET1}grpMB08323 No P{GawB}grpNP0269 No P{GawB}grpNP1225 No P{GawB}grpNP2668 No P{GawB}grpNP3042 No P{GawB}grpNP3606 No P{GawB}grpNP4260 No P{GawB}grpNP4265 No P{GawB}grpNP4755 No P{GawB}grpNP4781 No P{GawB}grpNP4791 No P{GawB}grpNP5294 No P{GawB}grpNP7402 No
Gene Ontology: Function, Process & Cellular Component ( 20 unique terms )
Terms Based on Experimental Evidence ( 9 terms )
Molecular Function ( 0 terms)
Biological Process
CV term Evidence References
cell cycle inferred from mutant phenotype (Su et al., 1998) cell cycle arrest inferred from mutant phenotype (Grosshans et al., 2003) centrosome separation inferred from mutant phenotype (Stumpff et al., 2005) DNA damage checkpoint inferred from mutant phenotype (Brodsky et al., 2000, LaRocque et al., 2007) inferred from mutant phenotype AND inferred from sequence or structural similarity (assigned by UniProtKB) (Fogarty et al., 1997) female meiosis chromosome segregation inferred from mutant phenotype (Dobie et al., 2001) mitotic cell cycle G2/M transition DNA damage checkpoint inferred from genetic interaction with nbs (Kondo and Perrimon, 2011) inferred from mutant phenotype (Kondo and Perrimon, 2011) regulation of syncytial blastoderm mitotic cell cycle inferred from mutant phenotype (assigned by UniProtKB) (Fogarty et al., 1997) spindle assembly inferred from mutant phenotype (Stumpff et al., 2005)
Cellular Component
CV term Evidence References
nucleus inferred from direct assay (assigned by UniProtKB) (Fogarty et al., 1997)
Terms Based on Predictions or Assertions ( 13 terms )
Molecular Function
CV term Evidence References
ATP binding inferred from electronic annotation with InterPro:IPR000719, InterPro:IPR002290, InterPro:IPR017441 (FlyBase Curators et al., 2004-) protein kinase activity inferred from sequence or structural similarity with human CHEK1 (Sekelsky et al., 2000) inferred from sequence or structural similarity with Saccharomyces CHK1 (Price et al., 1999) non-traceable author statement (Morrison et al., 2000) protein serine/threonine kinase activity inferred from electronic annotation with InterPro:IPR008271 (FlyBase Curators et al., 2004-) inferred from sequence or structural similarity (Kalderon and Rubin, 1988) inferred from sequence or structural similarity (assigned by UniProtKB) (Fogarty et al., 1997) traceable author statement (Sibon, 1999)
Biological Process
CV term Evidence References
cell cycle checkpoint inferred from sequence or structural similarity with human CHEK1 (Sekelsky et al., 2000) traceable author statement (Lee and Orr-Weaver, 2003) cellularization traceable author statement (Walworth, 2000) DNA damage checkpoint inferred from sequence or structural similarity with Saccharomyces CHK1 (Price et al., 1999) traceable author statement (Sekelsky et al., 2000) embryonic development via the syncytial blastoderm traceable author statement (Walworth, 2000, Lee and Orr-Weaver, 2003) imaginal disc development traceable author statement (Walworth, 2000) mitotic cell cycle checkpoint traceable author statement (Walworth, 2000) protein phosphorylation inferred from sequence or structural similarity (Kalderon and Rubin, 1988) inferred from sequence or structural similarity with human CHEK1 (Sekelsky et al., 2000) non-traceable author statement (Morrison et al., 2000) non-traceable author statement (assigned by UniProtKB) (Fogarty et al., 1997) regulation of proteolysis traceable author statement (Lee and Orr-Weaver, 2003) regulation of syncytial blastoderm mitotic cell cycle traceable author statement (Brodsky et al., 2000) response to radiation traceable author statement (Walworth, 2000)
Cellular Component ( 0 terms)
Sequence Ontology: Class of Gene
	gene   gene_with_dicistronic_primary_transcript (FlyBase Genome Annotators, 2004) nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Protein-protein
Interacting group Assay References
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions grp allele Gene References grp06034 CycA (Su et al., 1999) grpfsA4 lok (Takada et al., 2003) mei-41 (Sibon et al., 1999) ms(3)K81 (Grosshans et al., 2003) unspecified Nsf2 (Laviolette et al., 2005) pbl (Gregory et al., 2007)
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 61001 DPiM - DPiM, Drosophila Protein interaction Map • FBgn0261278 DroID - A comprehensive database of gene and protein interactions. • FBgn0261278 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 34993
Orthologs
Genome-wide drosophilid orthologs	Dana\GF14005 Dere\GG22761 Dgri\GH25199 Dmoj\GI17268 Dper\GL19651 Dpse\GA26044 Dsec\GM17194 Dvir\GJ22747 Dwil\GK18348 Dyak\GE12755
Curated drosophilid orthologs	Dsim\grp (Ferree and Sullivan, 2006)
Linkouts	InParanoid A subset of ortholog calls from InParanoid. • AAEL013066-PA Aedes aegypti (mosquito) AGAP008118-PA Anopheles gambiae (mosquito) XP_623436.1 Apis mellifera (honey bee) XP_001951665.1 Acyrthosiphon pisum (pea aphid) At2g26980.3 Arabidopsis thaliana (wall cress) 31127 Batrachochytrium dendrobatidis (chytrid fungus) 59419 Branchiostoma floridae (lancelet) ENSBTAP00000023380 Bos taurus (bovine) CN26036 Caenorhabditis brenneri (small nematode) CBP15640 Caenorhabditis briggsae (nematode) CE26076 Caenorhabditis elegans (worm) ENSCAFP00000015534 Canis familiaris (dog) ENSCINP00000016265 Ciona intestinalis (sea squirt) cn07073 Cryptococcus neoformans (yeast-like fungus) CPIJ005290 Culex pipens (mosquito) ENSCPOP00000014681 Cavia porcellus (guinea pig) 132038 Chlamidomonas reinhardtii (green alga) 53567 Chlamidomonas reinhardtii (green alga) RP26134 Caenorhabditis remanei (nematode) ENSCSAVP00000001206 Ciona savignyi (sedentary tunicate) 106564 Capitella spl (polychaete worm) DEHA2C08272g Debaryomyces Hansenii (yeast) 43327 Daphnia pulex (daphnia) ENSDARP00000092552 Danio rerio (zebra fish) ENSECAP00000009999 Equus caballus (horse) ENSGACP00000027293 Gymnopilus aculeatus (mushroom) 189278 Hypsipyla robusta (cedar shoot borer) ENSP00000278916 Homo sapiens (human) ISCW012009-PA Ixodes scapularis (deer tick) KLLA0F01276g Kluyveromyces lactis (yeast) 173967 Lottia gigantea (owl limpet) ENSMODP00000005092 Monodelphis domestica (gray opossum) ENSMMUP00000011489 Macaca mulatta (rhesus monkey) ENSMUSP00000034625 Mus musculus (house mouse) 139755 Nematostella vectensis (starlet anemone) ENSOANP00000010076 Ornithorynchus anatinus (platypus) ENSORLP00000007199 Oryzias latipes (japanese killifish) LOC_Os07g05620.1 Oryza sativa (asian rice) PHUM005664-PA Pediculus humanus (human body louse) PP06818 Pristionchus pacificus (nematode) 143594 Physcomitrella patens (moss) 221343 Physcomitrella patens (moss) ENSPPYP00000004613 Pongo pygmaeus (orangutan) 83026 Phytophthora ramorum (sudden oak death pathogen) 128510 Phytophthora sojae (root rot pathogen) ENSPTRP00000007593 Pan troglodytes (chimpanzee) ENSRNOP00000011226 Rattus norvegicus (norway rat) 148844 Sorghum bicolor (sorghum) Smp_077180 Schistosoma mansoni (trematode parasite) XP_797565.2 Strongylocentrotus purpuratus (purple sea urchin) 24287 Trichoplax adhaerens (metazoa) XP_969818.1 Tribolium castaneum (red flour beetle) ENSTNIP00000012875 Tetraodon nigroviridis (green spotted pufferfish) ENSTRUP00000043875 Takifugu rubripes (pufferfish Takifugu) ENSXETP00000032528 Xenopus tropicalis (frog) OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • NV14014 LH12092 ISCW012009 FBgn0230477 FBgn0222192 FBgn0220346 FBgn0209851 FBgn0195427 FBgn0195426 FBgn0172105 JGI_V11_43327 FBgn0247421 FBgn0157249 FBgn0140012 FBgn0132654 FBgn0114926 FBgn0091032 CPIJ005290 BGIBMGA005856 ACYPI009656 ACYPI008587 GB16086 AGAP008118 AAEL017382 AAEL013066 PB21034 PHUM346290 GLEAN_01409
Stocks & Reagents
Stocks Listed in FlyBase ( 40 )
Harvard	- P{XP}grpd02837 - P{XP}grpd10141 - PBac{PB}grpc01254 - PBac{PB}grpc04899 - PBac{RB}grpe00087 - PBac{RB}grpe02195 - PBac{WH}grpf00841 - PBac{WH}grpf03358
Kyoto	104353 w*; P{GawB}grpNP3042 113368 w*; P{GawB}grpNP3606 200874 w*; P{GSV3}grpGS6056/SM1
VDRC	v12680 w1118; P{GD4189}v12680/TM3
	More stocks available...
Genomic Clones ( 1 )
	BACR26O03 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 118 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	AT13792 LD42896
Other clones	DPiM_LD42896
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	AT14317 AT16290 AT19361 AT27359 GM13457 LD09905 LD20111 LD26850 LD26974 LD27088 LD39588 LD42288 LP05380 RE02246 RE13853 RE15558 RE18201 RE23682 RE24818 RE26643 RE30160 RE33507 RE34839 RE36321 RE36907 RE37270 RE41107 RE41431 RE41688 RE42284 RE43961 RE45702 RE45708 RE47618 RE48846 RE50325 RE52119 RE55370 RE59569 RE61114 RE63394 RE64594 RE66246 RE66741 RE69565 RE69666 RE70401 RH20726 SD26352
Other clones	30901 32195 43788 214353.28 273233 bs04f04 CK01.6B.C11 CK01.33D.E10 CK00051 Dmel_dig_006677_0656_1867 Dmel_dig_014001_0673_1145 Dmel_dig_017563_0630_0657 Dmel_neb_012932_0891_3498 EC052491 EC052494 EC053039 EC055373 EC055785 EK009312 EK138203 EK140860 EK144504 EK163310 EK175031 EK258954 EK302308 FGM235B10 LD14845 RP003033220 RP003127983 RP003167717 RP003173515 RP003212025 RP003223092 RP003514570 RP003555173 RP003559211 RP003584282 RP003611986 RP003632037 RP004120056 RP004159172 RP004161378 RP004166151 RP004174537 RP004175589 RP004201531 RP004203086 RP004204123 RP004220916 RP004228296 RP004235999 RP004236071 RP004245158 RP004250456 RP004259851 RP004365350 RP004470184 RP004471569 RP004479870 RP004487479 RP004488069 RP004518054 RP004518756 RP004520143 RP004540961
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0261278 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 34993
Antibody Information
	polyclonal (Purdy et al., 2005, de Vries et al., 2005)
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of
Source for database merge of	Source for merge of: grp l(2)k15102 (FlyBase, 1996-) Source for merge of: grp lemp (Li et al., 1998) Source for merge of: grp Pk36A (Bayraktaroglu, 2000.11.2)
Additional comments	Annotation CG4711 has been restored as a distinct annotation from CG17161 in release 3.2 of the genome annotation. In addition, release 3.2 annotations CG17161 (which corresponds to grp) and CG4711 encode alternative transcripts which share untranslated sequences, but encode non-overlapping open reading frames. (FlyBase Genome Annotators, 2004) Release 1 annotation CG4711 (which was eliminated in release 2 of the genome annotation) has been merged with CG17161 in release 3 of the genome annotation. (FlyBase Genome Annotators, 2002-2003)
Other Comments
	Expression is enriched in embryonic gonads. (Shigenobu et al., 2006) When dsRNA constructs are made and transiently transfected into S2 cells in RNAi experiments, spindle abnormalities, chromosome alignment defects, lagging chromatids are seen. (Bettencourt-Dias et al., 2004) S2 cells are treated with dsRNA made from templates generated with primers directed against this gene to assess effect on proteolysis of dup and geminin genes. (Higa et al., 2003) dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R+ cell morphology. (Kiger et al., 2003) grp is required for normal CycA turnover in the early embryo, and may activate CycA proteolysis. (Su et al., 1999) Transcription unit identified during molecular analysis of the her gene region. (Li and Baker, 1998) Interphase lengthening during somatic cycles 10-13 requires grp, delay in polar nuclear divisions is grp-independent. (Su et al., 1998) Molecular characterisation of grp and cellular analysis of grp mutants. (Fogarty et al., 1997) Mutations in grp block the morphological and biochemical changes that accompany the midblastula transition (MBT), lead to a continuation of the maternal cell-cycle programme and disrupt DNA-replication checkpoint control of cell-cycle progression. (Sibon et al., 1997) X-irradiation of grp derived embryos results in metaphase arrest even during the pre-migration and initial cortical nuclear cycles. (Fogarty et al., 1994) Deficiency analysis localized grp to 36A8-36D1. (Sullivan et al., 1993) Defined in a screen of maternal-effect lethal mutations that cause defects in nuclear movement, organization or morphology during the syncytial embryonic divisions. (Sullivan et al., 1993) Isolated from a genomic library using a Pka-C1 probe. (Kalderon and Rubin, 1988) grp may encode a protein kinase. (Kalderon and Rubin, 1988) Gene in D.melanogaster encoding product related (by sequence comparison) to the serine-threonine protein kinases of mammals. Isolated from Drosophila clones obtained with mammalian probes.
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_057663 NM_165171 NM_165172 NM_165173 RefSeq (Proteins) • NP_477011 NP_723985 NP_723986 NP_723987 DDBJ / EMBL / GenBank • AAC13566 AAF53551 AAF53551.2 AAF53552 AAF53552.2 AAK93385 AAN10952 AAN10952.1 AAN10953 AC005133 AC006214 AF057041 AI516426 AI516821 AI944721 AQ024960 AQ024988 AQ025028 AQ026086 AQ073387 AQ073508 AQ073692 AQ073724 AQ073736 AW943628 AY051961 AZ300924 BZ286410 CL526126 CL943523 CZ467001 CZ467018 CZ469594 CZ469595 CZ470220 CZ473024 CZ475799 CZ477991 CZ480020 CZ485912 CZ486156 CZ489622 CZ489623 Entrez Gene - A searchable database of RefSeq genes. • 34993 UniProtKB/Swiss-Prot • O61661
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Protein kinase, catalytic domain (IPR000719) Serine/threonine-protein kinase, catalytic domain (IPR002290) Serine/threonine-protein kinase, active site (IPR008271) Protein kinase-like domain (IPR011009) Protein kinase, ATP binding site (IPR017441) Serine/threonine-protein kinase-like domain (IPR017442)
Linkouts
	BioGRID - A database of protein and genetic interactions • 61001 DPiM - DPiM, Drosophila Protein interaction Map • FBgn0261278 DroID - A comprehensive database of gene and protein interactions. • FBgn0261278 DRSC - Results from RNAi screens. • FBgn0261278 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0261278 FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0261278 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 34993 InParanoid A subset of ortholog calls from InParanoid. • AAEL013066-PA Aedes aegypti (mosquito) AGAP008118-PA Anopheles gambiae (mosquito) XP_623436.1 Apis mellifera (honey bee) XP_001951665.1 Acyrthosiphon pisum (pea aphid) At2g26980.3 Arabidopsis thaliana (wall cress) 31127 Batrachochytrium dendrobatidis (chytrid fungus) 59419 Branchiostoma floridae (lancelet) ENSBTAP00000023380 Bos taurus (bovine) CN26036 Caenorhabditis brenneri (small nematode) CBP15640 Caenorhabditis briggsae (nematode) CE26076 Caenorhabditis elegans (worm) ENSCAFP00000015534 Canis familiaris (dog) ENSCINP00000016265 Ciona intestinalis (sea squirt) cn07073 Cryptococcus neoformans (yeast-like fungus) CPIJ005290 Culex pipens (mosquito) ENSCPOP00000014681 Cavia porcellus (guinea pig) 132038 Chlamidomonas reinhardtii (green alga) 53567 Chlamidomonas reinhardtii (green alga) RP26134 Caenorhabditis remanei (nematode) ENSCSAVP00000001206 Ciona savignyi (sedentary tunicate) 106564 Capitella spl (polychaete worm) DEHA2C08272g Debaryomyces Hansenii (yeast) 43327 Daphnia pulex (daphnia) ENSDARP00000092552 Danio rerio (zebra fish) ENSECAP00000009999 Equus caballus (horse) ENSGACP00000027293 Gymnopilus aculeatus (mushroom) 189278 Hypsipyla robusta (cedar shoot borer) ENSP00000278916 Homo sapiens (human) ISCW012009-PA Ixodes scapularis (deer tick) KLLA0F01276g Kluyveromyces lactis (yeast) 173967 Lottia gigantea (owl limpet) ENSMODP00000005092 Monodelphis domestica (gray opossum) ENSMMUP00000011489 Macaca mulatta (rhesus monkey) ENSMUSP00000034625 Mus musculus (house mouse) 139755 Nematostella vectensis (starlet anemone) ENSOANP00000010076 Ornithorynchus anatinus (platypus) ENSORLP00000007199 Oryzias latipes (japanese killifish) LOC_Os07g05620.1 Oryza sativa (asian rice) PHUM005664-PA Pediculus humanus (human body louse) PP06818 Pristionchus pacificus (nematode) 143594 Physcomitrella patens (moss) 221343 Physcomitrella patens (moss) ENSPPYP00000004613 Pongo pygmaeus (orangutan) 83026 Phytophthora ramorum (sudden oak death pathogen) 128510 Phytophthora sojae (root rot pathogen) ENSPTRP00000007593 Pan troglodytes (chimpanzee) ENSRNOP00000011226 Rattus norvegicus (norway rat) 148844 Sorghum bicolor (sorghum) Smp_077180 Schistosoma mansoni (trematode parasite) XP_797565.2 Strongylocentrotus purpuratus (purple sea urchin) 24287 Trichoplax adhaerens (metazoa) XP_969818.1 Tribolium castaneum (red flour beetle) ENSTNIP00000012875 Tetraodon nigroviridis (green spotted pufferfish) ENSTRUP00000043875 Takifugu rubripes (pufferfish Takifugu) ENSXETP00000032528 Xenopus tropicalis (frog) InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 34993 modMine - Data generated by the modENCODE project. • FBgn0261278 OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • NV14014 LH12092 ISCW012009 FBgn0230477 FBgn0222192 FBgn0220346 FBgn0209851 FBgn0195427 FBgn0195426 FBgn0172105 JGI_V11_43327 FBgn0247421 FBgn0157249 FBgn0140012 FBgn0132654 FBgn0114926 FBgn0091032 CPIJ005290 BGIBMGA005856 ACYPI009656 ACYPI008587 GB16086 AGAP008118 AAEL017382 AAEL013066 PB21034 PHUM346290 GLEAN_01409
Synonyms & Secondary IDs ( 26 )
Reported As
Symbol Synonym	1C (Kalderon and Rubin, 1988, ) CG17161 (Norga et al., 2003, Morrison et al., 2000, Laviolette et al., 2005, Quinones-Coello, 2007, Keleman et al., 2009.8.5) Chk1 (Machida, 2005, Sutcliffe and Brehm, 2004, Mogila et al., 2007, Gregory et al., 2007, Tountas and Fortini, 2007, Garcia et al., 2007, Royou et al., 2008, Purdy et al., 2005, Rickmyre et al., 2007) CHK1 (Morrison et al., 2000, Crest et al., 2006, Cenci et al., 2008, Katzenberger et al., 2006, Kondo and Perrimon, 2011) chk1 (Abdu et al., 2007, Brunk et al., 2007) CHK1/Grapes (Higa et al., 2003) dChk1 (Sibon, 1999) Dchk1 (Yi et al., 2009) DmChk1 (LaRocque et al., 2007) grp (Sakaguchi et al., 2008, Venken, 2006, Mukai et al., 2006, McCaffrey et al., 2006, Jaklevic et al., 2006, Laviolette et al., 2005, Hochwagen, 2006, Shigenobu et al., 2006, Venken et al., 2006, LaRocque et al., 2007, Garcia et al., 2007, Sakaguchi and Steward, 2007, Bi et al., 2005, Buszczak et al., 2007, Quinones-Coello, 2007, Takada et al., 2007, LaRocque et al., 2007, McNamee and Brodsky, 2008, Cenci et al., 2008, Lecuyer et al., 2007, Georlette et al., 2007, Minidorff et al., 2007, Markstein et al., 2008, Mogila et al., 2006, Raymond et al., 2004, Purdy et al., 2005, Rickmyre et al., 2007, Titen and Golic, 2008, Brunk et al., 2007, Benoit et al., 2009, Peng and Karpen, 2009, Pane et al., 2007, Peretz et al., 2009, Perkins et al., 2009.8.10, Merkle et al., 2009, Musarò et al., 2008, Oikemus et al., 2006, McCleland et al., 2009, Abdu et al., 2007, Radcliffe et al., 2002, Silva et al., 2006, Campos et al., 2010, Burgio et al., 2008, Smolik and Jones, 2007, Kondo and Perrimon, 2011, Yi et al., 2009, Reis et al., 2010) Grp (Bettencourt-Dias et al., 2004, Li et al., 2010, Royou et al., 2010, Malzer et al., 2010) Grp/DChk1 (de Vries et al., 2005) grp(chk) (Royou et al., 2010) grps (Brodsky et al., 2004) l(2)k15102   lemp (Li et al., 1998, Li and Baker, 1998, ) Pk36A   Pk?1
Name Synonym	Checkpoint kinase 1   checkpoint kinase 1 (Royou et al., 2008) Chk1/Grapes (Mihaylov et al., 2002) grapes (Sakaguchi et al., 2008, Turner et al., 2008, Laurencon et al., 1998, Sullivan et al., 1993, Ferree and Sullivan, 2006, Mukai et al., 2006, Gregory et al., 2007, Garcia et al., 2007, Tadros et al., 2007, Raymond et al., 2004, Abdu et al., 2007, Rickmyre et al., 2007, Stofanko et al., 2008, Rickmyre et al., 2007, Musarò et al., 2008, McCleland et al., 2009, Blower et al., 2006, Smolik and Jones, 2007, Malzer et al., 2010) Grapes (Royou et al., 2008, Purdy et al., 2005, Brunk et al., 2007, Li et al., 2010, Royou et al., 2010) last empress (Li and Baker, 1998, ) lethal (2) k15102   Protein kinase-like 36A
Secondary FlyBase IDs
	FBgn0004632 FBgn0011598 FBgn0021840 FBgn0024213 FBgn0040478 FBgn0069054
References ( 184 )
Generate a list of	All references relating to this gene ( 184 )
List References by type	Research paper  ( 98 ) Supplementary material  ( 9 ) Review  ( 17 ) Personal communication to FlyBase  ( 15 ) Abstract  ( 30 ) FlyBase analysis  ( 5 ) Conference report  ( 2 ) Computer file  ( 4 ) Curated genome annotation  ( 2 ) Automatic genome annotation  ( 1 ) Book  ( 1 )
Recent research papers ( 8 )
	Kondo and Perrimon, 2011, Sci. Signal. 4(154): rs1 A Genome-Wide RNAi Screen Identifies Core Components of the G2-M DNA Damage Checkpoint. [FBrf0212700] Morozova et al., 2011, Genetics 187(4): 1193--1205 Transcriptional networks for alcohol sensitivity in Drosophila melanogaster. [FBrf0214377] Blanco et al., 2010, BMC Dev. Biol. 10: 94 Gene expression following induction of regeneration in Drosophila wing imaginal discs. Expression profile of regenerating wing discs. [FBrf0211812] Campos et al., 2010, Genetics 184(1): 129--140 Genetic screen in Drosophila melanogaster uncovers a novel set of genes required for embryonic epithelial repair. [FBrf0209682] Li et al., 2010, PLoS Genet. 6(3): e1000876 Drosophila xpd regulates cdk7 localization, mitotic kinase activity, spindle dynamics, and chromosome segregation. [FBrf0210295] Malzer et al., 2010, J. Cell Sci. 123(17): 2892--2900 Impaired tissue growth is mediated by checkpoint kinase 1 (CHK1) in the integrated stress response. [FBrf0211608] Reis et al., 2010, PLoS Genet. 6(11): e1001206 A buoyancy-based screen of Drosophila larvae for fat-storage mutants reveals a role for sir2 in coupling fat storage to nutrient availability. [FBrf0212335] Royou et al., 2010, Cell 140(2): 235--245 BubR1- and Polo-Coated DNA Tethers Facilitate Poleward Segregation of Acentric Chromatids. [FBrf0209924] Show all research papers ...
Recent reviews (0)
	All reviews listed in FlyBase were published before 2010 Show reviews ...