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Gene Dmel\lqfR

General Information
Symbol	Dmel\lqfR	Species	D. melanogaster
Name	liquid facets-Related	Annotation symbol	CG42250
Feature type	protein_coding_gene	FlyBase ID	FBgn0261279
Gene Model Status	Current	Stock availability	10 publicly available
Also Known As	epsin-like, Epsin, l(3)XII-10
Genomic Location
Chromosome (arm)	3R	Recombination map	3-76.6
Cytogenetic map	94A12-94A12	Sequence location	3R:18,237,055..18,244,778 [+]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents modENCODE GBrowse	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene liquid facets-Related is referred to in FlyBase by the symbol Dmel\lqfR (CG42250, FBgn0261279). It is a protein_coding_gene from Drosophila melanogaster. Its molecular function is unknown. There is experimental evidence that it is involved in the biological process: cell proliferation. 15 alleles are reported. The phenotypes of these alleles are annotated with: eye disc; eye; trichogen cell; embryonic/larval salivary gland; cell cycle; wing; imaginal disc; ommatidium; wing hair. It has 2 annotated transcripts and 2 annotated polypeptides. Protein features are: ENTH/VHS; Epsin domain, N-terminal; Epsin-like, N-terminal; Telomere length regulation protein, conserved domain. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of moderate expression. Peak expression observed within 00-06 and 12-18 hour embryonic stages, in adult female stages. Summary of FlyAtlas Anatomical Expression Data: Two or more Affy2 ProbeSets identify exons of this gene. This is a summary of the tissue expression peaks exhibited in at least one of these ProbeSets. Expression in all larval and adult organs/tissues ranges from low to undetected. Expression at high levels in the following post-embryonic organs or tissues: larval/adult midgut, larval hindgut, larval Malpighian tubules, larval/adult salivary gland, adult male accessory gland. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, adult eye, larval/adult central nervous system, adult crop, adult hindgut, adult Malpighian tubules, adult heart, larval/adult fat body, larval trachea, adult female reproductive system, adult testis, larval/adult carcass. Gene sequence location is 3R:18237055..18244778.
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2012_01	Sequence features BKN45935 BKN23625 HFA14704 BKN22751 HFA14703
FB2011_10	References Burgess et al., 2011, Mol. Biol. Cell 22(12): 2094--2105
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 94A12-94A12   Limits computationally determined from genome sequence between P{PZ}l(3)rQ178rQ178 and P{lacW}Dph5L4910
Experimentally Determined Cytological Location
Cytogenetic map Notes References 94B-94B   Determined by comparing Celera genomic sequence with sequence from BDGP BAC and P1 clones.   (Lloyd et al., 2000) 94A8-94A12     (Su, 2000.2.9) 94A8-94A12   (determined by in situ hybridisation)   (Spradling et al., 1999) 94A8-94A12   (determined by in situ hybridisation)   (BDGP Project Members, 1994-1999)
Experimentally Determined Recombination Data
Location	3-76.6 (Gatti and Baker, 1989)
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\lqfR for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
	Gene merge based on EST/cDNA data
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) lqfR-RC FBtr0299515  NM_170009   2680   649 lqfR-RD FBtr0299516  NM_170011   4994   1415
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein lqfR-PC   FBpp0288789   69.4   649   4.89     NP_732734   AAF55990 lqfR-PD   FBpp0288790   158.0   1415   5.04     NP_732736   AAN14377
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Epsin domain, N-terminal (IPR001026) ENTH/VHS (IPR008942) Epsin-like, N-terminal (IPR013809) Telomere length regulation protein, conserved domain (IPR019337)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA540590   AA950851   AA950852   AA978547   AA978709   AE014297 AAF55990   AE014297 AAN14377   AF233291 AAF43421   AI062956   AI063156   AI513043   AI513812   AI534009   AQ026188   AW940101   AX925765 CAF02352   AY060606 AAL28154   BF495101   BF501489   BF503754   BF506000   BG640937   BI163622   BI166121   BI171835   BI171854   BI172258   BI214702   BI243384   BI358420   BI364323   BI365908   BI368143   BI368846   BI640626   BT030121   CO186431   CO188282   CO262854   CO264540   CO267980   CO268214   CO277120   CO277440   CO278689   CO287348   CO288171   CO288796   CO290992   CO293819   CO301820   CO303708   CO305308   CO309041   CO309652   CO317126   CO317283   CO329469   CO342984   CO343173   CO345100   CZ475234   EC071057   EC073111   EC075910   EC082296   EC083155   EC089678   EC091199   EC194796   EC203837   EC204140   EC208107   EC208108   EC210679   EC214720   EC218963   EC231395   EC232272   EC239329   EC242345   EC244291   EC245908   EC247252   EC249912   EC252242   EC256116   EC257552   EC259542   EC260131   EL883713   EL883817   EL883931   EV579171   EV579930   EV589873   GH942782   GH943123   GH943441   GH943900   GH943915   GH944299   GH945340   GH945616   GH946245   GH946947   GH948271   GH953679   GH955040   GH956596   GH961161   GH961289   GH963568   GH964255   GH964680   GH965811   GH965914   GH967553   GH968889   GH969246   GH971455   GH971941   GH972169   GH975379   GH976457   GH980750   GH981343   GH981592   GH984805
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL	Q9NH51 Q9VD13 Q8IN05
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
Polypeptide Expression
mass spectroscopy Stage Tissue/Position (including subcellular localization) Reference day 5 of adulthood & male -- day 7 of adulthood & male   spermatozoon   (Wasbrough et al., 2010)
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
High-Throughput Expression Data
or
See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes. modENCODE Temporal Expression Data for FBgn0261279    Styles Linear Logarithmic Heatmap    Scales max expr for FBgn0261279 Very low expression bin max Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of moderate expression. Peak expression observed within 00-06 and 12-18 hour embryonic stages, in adult female stages. [download data (TSV)] Guide to modENCODE expression level colors   No expression (0 - 0)   Extremely low expression (1 - 10)   Very low expression (11 - 100)   Low expression (101 - 400)   Moderate expression (401 - 1400)   Moderately high expression (1401 - 4000)   High expression (4001 - 10000)   Very high expression (10001 - 100000)   Extremely high expression (100001 - 2000000) Linear, scaled to maximum FBgn0261279 expression level Developmental Stage   Expression Level embryo 00-02hr    3163 embryo 02-04hr    1088 embryo 04-06hr    741 embryo 06-08hr    1184 embryo 08-10hr    1203 embryo 10-12hr    1377 embryo 12-14hr    1339 embryo 14-16hr    1539 embryo 16-18hr    1508 embryo 18-20hr    1195 embryo 20-22hr    1252 embryo 22-24hr    1166 larva L1    968 larva L2    1075 larva L3 12hr old    930 larva L3 puffstage 1-2    1019 larva L3 puffstage 3-6    1292 larva L3 puffstage 7-9    1271 white prepupae new    1096 white prepupae 12hr    1061 white prepupae 24hr    1107 pupae 2d postWPP    1245 pupae 3d postWPP    1016 pupae 4d postWPP    780 adult male 01day    1148 adult male 05day    1367 adult male 30day    1225 adult female 01day    1329 adult female 05day    2086 adult female 30day    2119 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  Linear, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (3163) embryo 02-04hr  (1088) embryo 04-06hr  (741) embryo 06-08hr  (1184) embryo 08-10hr  (1203) embryo 10-12hr  (1377) embryo 12-14hr  (1339) embryo 14-16hr  (1539) embryo 16-18hr  (1508) embryo 18-20hr  (1195) embryo 20-22hr  (1252) embryo 22-24hr  (1166) larva L1  (968) larva L2  (1075) larva L3 12hr old  (930) larva L3 puffstage 1-2  (1019) larva L3 puffstage 3-6  (1292) larva L3 puffstage 7-9  (1271) white prepupae new  (1096) white prepupae 12hr  (1061) white prepupae 24hr  (1107) pupae 2d postWPP  (1245) pupae 3d postWPP  (1016) pupae 4d postWPP  (780) adult male 01day  (1148) adult male 05day  (1367) adult male 30day  (1225) adult female 01day  (1329) adult female 05day  (2086) adult female 30day  (2119) Expression Level Scale  None   Extremely low   Very low   Low  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (3163) embryo 02-04hr    1088 embryo 04-06hr    741 embryo 06-08hr    1184 embryo 08-10hr    1203 embryo 10-12hr    1377 embryo 12-14hr    1339 embryo 14-16hr  (1539) embryo 16-18hr  1508 embryo 18-20hr    1195 embryo 20-22hr    1252 embryo 22-24hr    1166 larva L1    968 larva L2    1075 larva L3 12hr old    930 larva L3 puffstage 1-2    1019 larva L3 puffstage 3-6    1292 larva L3 puffstage 7-9    1271 white prepupae new    1096 white prepupae 12hr    1061 white prepupae 24hr    1107 pupae 2d postWPP    1245 pupae 3d postWPP    1016 pupae 4d postWPP    780 adult male 01day    1148 adult male 05day    1367 adult male 30day    1225 adult female 01day    1329 adult female 05day  (2086) adult female 30day  (2119) Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    3163 embryo 02-04hr    1088 embryo 04-06hr    741 embryo 06-08hr    1184 embryo 08-10hr    1203 embryo 10-12hr    1377 embryo 12-14hr    1339 embryo 14-16hr    1539 embryo 16-18hr    1508 embryo 18-20hr    1195 embryo 20-22hr    1252 embryo 22-24hr    1166 larva L1    968 larva L2    1075 larva L3 12hr old    930 larva L3 puffstage 1-2    1019 larva L3 puffstage 3-6    1292 larva L3 puffstage 7-9    1271 white prepupae new    1096 white prepupae 12hr    1061 white prepupae 24hr    1107 pupae 2d postWPP    1245 pupae 3d postWPP    1016 pupae 4d postWPP    780 adult male 01day    1148 adult male 05day    1367 adult male 30day    1225 adult female 01day    1329 adult female 05day    2086 adult female 30day    2119 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    3163 embryo 02-04hr    1088 embryo 04-06hr    741 embryo 06-08hr    1184 embryo 08-10hr    1203 embryo 10-12hr    1377 embryo 12-14hr    1339 embryo 14-16hr    1539 embryo 16-18hr    1508 embryo 18-20hr    1195 embryo 20-22hr    1252 embryo 22-24hr    1166 larva L1    968 larva L2    1075 larva L3 12hr old    930 larva L3 puffstage 1-2    1019 larva L3 puffstage 3-6    1292 larva L3 puffstage 7-9    1271 white prepupae new    1096 white prepupae 12hr    1061 white prepupae 24hr    1107 pupae 2d postWPP    1245 pupae 3d postWPP    1016 pupae 4d postWPP    780 adult male 01day    1148 adult male 05day    1367 adult male 30day    1225 adult female 01day    1329 adult female 05day    2086 adult female 30day    2119 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  log, scaled to maximum FBgn0261279 expression level Developmental Stage   Expression Level embryo 00-02hr    3163 embryo 02-04hr    1088 embryo 04-06hr    741 embryo 06-08hr    1184 embryo 08-10hr    1203 embryo 10-12hr    1377 embryo 12-14hr    1339 embryo 14-16hr    1539 embryo 16-18hr    1508 embryo 18-20hr    1195 embryo 20-22hr    1252 embryo 22-24hr    1166 larva L1    968 larva L2    1075 larva L3 12hr old    930 larva L3 puffstage 1-2    1019 larva L3 puffstage 3-6    1292 larva L3 puffstage 7-9    1271 white prepupae new    1096 white prepupae 12hr    1061 white prepupae 24hr    1107 pupae 2d postWPP    1245 pupae 3d postWPP    1016 pupae 4d postWPP    780 adult male 01day    1148 adult male 05day    1367 adult male 30day    1225 adult female 01day    1329 adult female 05day    2086 adult female 30day    2119 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High  log, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (3163) embryo 02-04hr  (1088) embryo 04-06hr  (741) embryo 06-08hr  (1184) embryo 08-10hr  (1203) embryo 10-12hr  (1377) embryo 12-14hr  (1339) embryo 14-16hr  (1539) embryo 16-18hr  (1508) embryo 18-20hr  (1195) embryo 20-22hr  (1252) embryo 22-24hr  (1166) larva L1  (968) larva L2  (1075) larva L3 12hr old  (930) larva L3 puffstage 1-2  (1019) larva L3 puffstage 3-6  (1292) larva L3 puffstage 7-9  (1271) white prepupae new  (1096) white prepupae 12hr  (1061) white prepupae 24hr  (1107) pupae 2d postWPP  (1245) pupae 3d postWPP  (1016) pupae 4d postWPP  (780) adult male 01day  (1148) adult male 05day  (1367) adult male 30day  (1225) adult female 01day  (1329) adult female 05day  (2086) adult female 30day  (2119) Expression Level Scale  None   Extremely low   Very low   Low  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (3163) embryo 02-04hr    1088 embryo 04-06hr    741 embryo 06-08hr    1184 embryo 08-10hr    1203 embryo 10-12hr    1377 embryo 12-14hr    1339 embryo 14-16hr  1539 embryo 16-18hr  1508 embryo 18-20hr    1195 embryo 20-22hr    1252 embryo 22-24hr    1166 larva L1    968 larva L2    1075 larva L3 12hr old    930 larva L3 puffstage 1-2    1019 larva L3 puffstage 3-6    1292 larva L3 puffstage 7-9    1271 white prepupae new    1096 white prepupae 12hr    1061 white prepupae 24hr    1107 pupae 2d postWPP    1245 pupae 3d postWPP    1016 pupae 4d postWPP    780 adult male 01day    1148 adult male 05day    1367 adult male 30day    1225 adult female 01day    1329 adult female 05day  2086 adult female 30day  2119 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    3163 embryo 02-04hr    1088 embryo 04-06hr    741 embryo 06-08hr    1184 embryo 08-10hr    1203 embryo 10-12hr    1377 embryo 12-14hr    1339 embryo 14-16hr    1539 embryo 16-18hr    1508 embryo 18-20hr    1195 embryo 20-22hr    1252 embryo 22-24hr    1166 larva L1    968 larva L2    1075 larva L3 12hr old    930 larva L3 puffstage 1-2    1019 larva L3 puffstage 3-6    1292 larva L3 puffstage 7-9    1271 white prepupae new    1096 white prepupae 12hr    1061 white prepupae 24hr    1107 pupae 2d postWPP    1245 pupae 3d postWPP    1016 pupae 4d postWPP    780 adult male 01day    1148 adult male 05day    1367 adult male 30day    1225 adult female 01day    1329 adult female 05day    2086 adult female 30day    2119 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    3163 embryo 02-04hr    1088 embryo 04-06hr    741 embryo 06-08hr    1184 embryo 08-10hr    1203 embryo 10-12hr    1377 embryo 12-14hr    1339 embryo 14-16hr    1539 embryo 16-18hr    1508 embryo 18-20hr    1195 embryo 20-22hr    1252 embryo 22-24hr    1166 larva L1    968 larva L2    1075 larva L3 12hr old    930 larva L3 puffstage 1-2    1019 larva L3 puffstage 3-6    1292 larva L3 puffstage 7-9    1271 white prepupae new    1096 white prepupae 12hr    1061 white prepupae 24hr    1107 pupae 2d postWPP    1245 pupae 3d postWPP    1016 pupae 4d postWPP    780 adult male 01day    1148 adult male 05day    1367 adult male 30day    1225 adult female 01day    1329 adult female 05day    2086 adult female 30day    2119 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     FlyAtlas Anatomical Expression Data for FBgn0261279    Styles Linear Logarithmic Heatmap Back-to-back    Scales max expr for FBgn0261279 Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Two or more Affy2 ProbeSets identify exons of this gene. This is a summary of the tissue expression peaks exhibited in at least one of these ProbeSets. Expression in all larval and adult organs/tissues ranges from low to undetected. Expression at high levels in the following post-embryonic organs or tissues: larval/adult midgut, larval hindgut, larval Malpighian tubules, larval/adult salivary gland, adult male accessory gland. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, adult eye, larval/adult central nervous system, adult crop, adult hindgut, adult Malpighian tubules, adult heart, larval/adult fat body, larval trachea, adult female reproductive system, adult testis, larval/adult carcass. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (1000 - 25000) Heatmap Tissue   Expression Level Larval Central Nervous System no informative data Larval Midgut no informative data Larval Hindgut no informative data Larval Malpighian Tubules no informative data Larval Fat Body no informative data Larval Salivary Gland no informative data Larval Trachea no informative data Larval Carcass no informative data Adult Head no informative data Adult Eye no informative data Adult Brain no informative data Adult Thoracic-Abdominal Ganglion no informative data Adult Crop no informative data Adult Midgut no informative data Adult Hindgut no informative data Adult Malpighian Tubules no informative data Adult Fat Body no informative data Adult Salivary Gland no informative data Adult Heart no informative data Adult VirginFemale Spermatheca no informative data Adult InseminatedFemale Spermatheca no informative data Adult Ovary no informative data Adult Testis no informative data Adult Male Accessory Gland no informative data Adult Carcass no informative data modENCODE Temporal Expression Data (Graveley et al., 2011) FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
Expression Clusters
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0261279
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele lethal | larval stage | recessive lqfRSG62 lethal | pupal stage (with lqfR03685) lqfRΔ117 lethal | pupal stage (with lqfRΔ117) lqfR03685 lethal | recessive | third instar larval stage lqfRΔ117 semi-lethal | pharate adult stage | recessive | heat sensitive lqfR03685 viable, with Scer\GAL4pnr-MD237 lqfRGD10186 lqfRGD10215 Other Phenotypes Allele decreased cell number | somatic clone lqfRΔ117 decreased cell size | cell autonomous | somatic clone lqfRΔ117 decreased cell size | larval stage lqfRΔ117 mitotic cell cycle defective lqfRSG62 visible, with Scer\GAL4pnr-MD237 lqfRGD10186 lqfRGD10215 visible | somatic clone lqfRΔ117 Phenotype manifest in Allele anterior scutellar bristle | ectopic lqfR03685 cell cycle lqfRSG62 embryonic/larval salivary gland lqfRΔ117 eye lqfR03685 eye | somatic clone lqfRΔ117 eye disc lqfR03685 eye disc | somatic clone lqfRΔ117 imaginal disc lqfRΔ117 lqfRSG62 ommatidium lqfR03685 ommatidium | somatic clone lqfRΔ117 rhabdomere | somatic clone lqfRΔ117 trichogen cell, with Scer\GAL4pnr-MD237 lqfRGD10186 lqfRGD10215 wing lqfR03685 wing hair lqfR03685
Classical Alleles ( 5 )
For All Classical Alleles Show
Allele of lqfR Class Mutagen Stocks Known lesion lqfR03685 hypomorphic allele - genetic evidence P-element activity 1 Yes lqfRd06591 P-element activity 1 -- lqfRMB11643 1 -- lqfRSG62 ICR 170 1 -- lqfRΔ117 loss of function allele Delta2-3 0 Yes
Alleles Carried on Transgenic Constructs ( 10 )
For All Alleles Carried on Transgenic Constructs Show
Allele of lqfR Class Mutagen Stocks Known lesion lqfRGD10186 in vitro construct - RNAi in vitro construct - regulatory fusion 2 Yes lqfRGD10215 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes lqfRHMS01423 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes lqfRJF02864 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes lqfRKK101170 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes lqfR+t11.5 in vitro construct - genomic fragment 0 Yes lqfRa.Scer\UAS.T:Avic\GFP in vitro construct - regulatory fusion 0 Yes lqfRa.Scer\UAS in vitro construct - regulatory fusion 0 Yes lqfRΔENTH.a.Scer\UAS.T:Avic\GFP in vitro construct - regulatory fusion 0 Yes lqfRΔENTH in vitro construct - deletion 0 Yes
Aneuploid Aberrations
Not disrupted in	Df(3R)e-BS2 (Spradling et al., 1999, BDGP Project Members, 1994-1999) Df(3R)e-N19 (Spradling et al., 1999, BDGP Project Members, 1994-1999) Df(3R)hhE23 (Spradling et al., 1999, BDGP Project Members, 1994-1999)
Disrupted in	Df(3R)BSC511 (Christensen et al., 2008.4.15) Df(3R)BSC523 (Christensen et al., 2008.6.11) Df(3R)BSC685 (Christensen et al., 2008.12.28) Df(3R)Exel6191 (Ryder, 2004.4.26)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{KK101170} NA P{TRiP.HMS01423} NA P{TRiP.JF02864} NA P{UAS-lqfR.a.GFP} NA P{UAS-lqfR.a.ΔENTH.GFP} NA P{UAS-lqfR.a} NA characterization construct P{lqfR+t11.5} NA P{lqfRΔENTH} NA
Insertions
	Type of insertions Name Expression data insertion of mobile activating element P{XP}lqfRd06591 NA insertion of enhancer trap P{PZ}lqfR03685 No insertion of enhancer trap binary system Mi{ET1}lqfRMB11643 No
Gene Ontology: Function, Process & Cellular Component ( 4 unique terms )
	There is no information supporting a molecular function term for this gene. (Based on a review of available data before: 2006)
Terms Based on Experimental Evidence ( 2 terms )
Molecular Function ( 0 terms)
Biological Process
CV term Evidence References
cell proliferation inferred from mutant phenotype (Lee et al., 2009)
Cellular Component
CV term Evidence References
Golgi apparatus inferred from direct assay (Lee et al., 2009)
Terms Based on Predictions or Assertions ( 2 terms )
Molecular Function ( 0 terms)
Biological Process
CV term Evidence References
neurotransmitter secretion non-traceable author statement (Lloyd et al., 2000) synaptic vesicle endocytosis non-traceable author statement (Lloyd et al., 2000)
Cellular Component ( 0 terms)
Sequence Ontology: Class of Gene
	gene   nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Protein-protein
Interacting group Assay References
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions lqfR allele Gene References
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 67588 DroID - A comprehensive database of gene and protein interactions. • FBgn0261279 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 42632
Orthologs
Genome-wide drosophilid orthologs	Dgri\GH20417 Dgri\GH20428 Dsim\GD20947
Curated drosophilid orthologs	Dpse\GA16061   Dpse\GA16148
Linkouts	InParanoid A subset of ortholog calls from InParanoid. • AAEL013724-PA Aedes aegypti (mosquito) AGAP004505-PA Anopheles gambiae (mosquito) XP_396583.3 Apis mellifera (honey bee) BGIBMGA010785-PA Bombyx mori (silk worm) ENSBTAP00000025412 Bos taurus (bovine) ENSCAFP00000028923 Canis familiaris (dog) CPIJ012986 Culex pipens (mosquito) ENSDARP00000049503 Danio rerio (zebra fish) ENSECAP00000015616 Equus caballus (horse) 160268 Hypsipyla robusta (cedar shoot borer) ENSMODP00000020203 Monodelphis domestica (gray opossum) 109335 Nematostella vectensis (starlet anemone) XP_001603684.1 Nasonia vitripennis (wasp) PHUM005704-PA Pediculus humanus (human body louse) ENSRNOP00000022670 Rattus norvegicus (norway rat) XP_001191369.1 Strongylocentrotus purpuratus (purple sea urchin) 53547 Trichoplax adhaerens (metazoa) XP_973547.1 Tribolium castaneum (red flour beetle) Tc00.1047053506925.70 Trypanosoma cruzi (parasitic trypanosome) 3724.m00063 Tetrahymena thermophila (ciliate protozoa) OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • NV17015 NV17014 LH13154 ISCW011655 ISCW008441 FBgn0228170 FBgn0215080 FBgn0211497 FBgn0192404 FBgn0181284 JGI_V11_1144 JGI_V11_45458 FBgn0247912 FBgn0161803 FBgn0145112 FBgn0127891 FBgn0127880 FBgn0120853 FBgn0103434 FBgn0095465 CPIJ012987 CPIJ012986 BGIBMGA010785 ACYPI004805 ACYPI002884 GB15239 AGAP004504 AAEL013726 AAEL013724 PB23948 PHUM027970 GLEAN_12168
Stocks & Reagents
Stocks Listed in FlyBase ( 10 )
Bloomington	35013 y1 sc* v1; P{TRiP.HMS01423}attP2 9027 mwh1 red1 e1 lqfRSG62/TM1 29925 w1118; Mi{ET1}lqfRMB11643/TM6C, Sb1 28987 y1 v1; P{TRiP.JF02864}attP2 e*/TM3, Sb1 11601 ry506 P{PZ}lqfR03685/TM3, ryRK Sb1 Ser1
Harvard	- P{XP}lqfRd06591
VDRC	v103719 P{KK101170}VIE-260B v33799 w1118 P{GD10215}v33799 v25707 w1118; P{GD10186}v25707 v25709 w1118; P{GD10186}v25709
Genomic Clones ( 1 )
	BACR30J14 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 118 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	GH02671
Other clones	IP13269
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	AT03930 AT04950 AT08346 AT16845 GH02345 GH26911 LD20323 LD31001 LD31002 LD31207 LD32702 LD45260 RE03061 RE06151 RE13704 RE13725 RE14571 RE20807 RE41005 RE45186 RE49412 RE51312 RE54062 RE54894 SD06435 SD12123 SD23564
Other clones	1875 5387 30420 37272 39852 55409 74890 84052 145887 156822 162993 163481 166299 190507 CK01.2A.D9 CK01.21B.G10 CK01.85D.D9 CK01.97D.B2 CK01.103A.H11 CK01.107D.E3 CK01.118C.C4 Dmel_dig_004258_0687_0368 Dmel_dig_016034_0595_3553 Dmel_neb_015337_0322_2062 EC256116 EC257552 EC259542 EC260131 EK019559 EK038955 EK065623 EK067913 EK069403 EK075737 EK086532 EK089842 EK090618 EK123043 EK124426 EK131102 EK139527 EK182240 EK204924 EK218729 EK242608 EK248160 EK259954 EK267158 EK267618 EK292921 EP15856 EP16235 EP21318 IP13369 IP13469 IP13569 RP004047758 RP004075742 RP004104675 RP004126511 RP004198629 RP004214276 RP004221818 RP004229110 RP004230349 RP004231395 RP004232768 RP004237881 RP004242448 RP004244424 RP004246078 RP004250823 RP004253485 RP004257133 RP004319220 RP004343922 RP004401562 RP004404770 RP004412198 RP004444335 RP004448864 RP004466074 RP004486281 RP004487351 RP004500174 RP004507545 RP004513495 RP004536318 RP004537895
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0261279 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 42632 249560 318661
Antibody Information
	polyclonal (Lee et al., 2009)
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of
Source for database merge of	Source for merge of: CG13853 CG13854 (FlyBase, 1996-) Source for merge of: CG31170 l(3)03685 epsin-2 (FlyBase, 1996-) Source for merge of: epsin-like CG31285 (FlyBase Genome Annotators, 2008) Source for merge of: epsin-like epsin-2 (FlyBase, 1996-) Source for merge of: l(3)dsl9 l(3)SG62 (Shearn, 1995.5.3) Source for merge of: l(3)SG62 epsin-like (Lee et al., 2009)
Additional comments	Annotations CG31170 and CG31285 merged as CG42250 in release 5.7 of the genome annotation. (FlyBase Genome Annotators, 2008) Annotations CG13853, CG13854 merged as CG31170 in release 3 of the genome annotation. (FlyBase Genome Annotators, 2002-2003) Source for merge of CG31170 l(3)03685 epsin-2 was sequence comparison (date:050505). (FlyBase, 1996-) Source for merge of CG13853 CG13854 was a shared cDNA (date:010720). (FlyBase, 1996-) Source for merge of epsin-like epsin-2 was cytological position (date:001221). (FlyBase, 1996-)
Other Comments
	New annotation (CG31285) in release 3 of the genome annotation. (FlyBase Genome Annotators, 2002-2003)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_170009 NM_170011 RefSeq (Proteins) • NP_732734 NP_732736 DDBJ / EMBL / GenBank • AA540590 AAF43421 AAF55990 AAL28154 AAN14377 AF233291 AI063156 AQ026188 AW940101 AX925765 AY060606 CAF02352 CZ475234 Entrez Gene - A searchable database of RefSeq genes. • 42632 UniProtKB/TrEMBL • Q8IN05 Q9NH51 Q9VD13
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Epsin domain, N-terminal (IPR001026) ENTH/VHS (IPR008942) Epsin-like, N-terminal (IPR013809) Telomere length regulation protein, conserved domain (IPR019337)
Linkouts
	BioGRID - A database of protein and genetic interactions • 67588 DroID - A comprehensive database of gene and protein interactions. • FBgn0261279 DRSC - Results from RNAi screens. • FBgn0261279 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0261279 FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0261279 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 42632 249560 318661 InParanoid A subset of ortholog calls from InParanoid. • AAEL013724-PA Aedes aegypti (mosquito) AGAP004505-PA Anopheles gambiae (mosquito) XP_396583.3 Apis mellifera (honey bee) BGIBMGA010785-PA Bombyx mori (silk worm) ENSBTAP00000025412 Bos taurus (bovine) ENSCAFP00000028923 Canis familiaris (dog) CPIJ012986 Culex pipens (mosquito) ENSDARP00000049503 Danio rerio (zebra fish) ENSECAP00000015616 Equus caballus (horse) 160268 Hypsipyla robusta (cedar shoot borer) ENSMODP00000020203 Monodelphis domestica (gray opossum) 109335 Nematostella vectensis (starlet anemone) XP_001603684.1 Nasonia vitripennis (wasp) PHUM005704-PA Pediculus humanus (human body louse) ENSRNOP00000022670 Rattus norvegicus (norway rat) XP_001191369.1 Strongylocentrotus purpuratus (purple sea urchin) 53547 Trichoplax adhaerens (metazoa) XP_973547.1 Tribolium castaneum (red flour beetle) Tc00.1047053506925.70 Trypanosoma cruzi (parasitic trypanosome) 3724.m00063 Tetrahymena thermophila (ciliate protozoa) InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 42632 modMine - Data generated by the modENCODE project. • FBgn0261279 OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • NV17015 NV17014 LH13154 ISCW011655 ISCW008441 FBgn0228170 FBgn0215080 FBgn0211497 FBgn0192404 FBgn0181284 JGI_V11_1144 JGI_V11_45458 FBgn0247912 FBgn0161803 FBgn0145112 FBgn0127891 FBgn0127880 FBgn0120853 FBgn0103434 FBgn0095465 CPIJ012987 CPIJ012986 BGIBMGA010785 ACYPI004805 ACYPI002884 GB15239 AGAP004504 AAEL013726 AAEL013724 PB23948 PHUM027970 GLEAN_12168
Synonyms & Secondary IDs ( 23 )
Reported As
Symbol Synonym	CG13853   CG13854   CG31170 (Giot et al., 2003, ) CG31285   CG42250 (Lee et al., 2009, Keleman et al., 2009.8.5, Perkins et al., 2009, Benhra et al., 2011, Ni et al., 2011.7.19) Epsin (Jafar-Nejad et al., 2002) epsin (Oldham et al., 2002) epsin02 (Lee et al., 2006) epsin-like (Wendler et al., 2010, FlyBase Genome Annotators, 2008, Christensen et al., 2008.4.15, Christensen et al., 2008.6.11, Christensen et al., 2008.12.28) l(3)03685 (Spradling et al., 1999, ) l(3)A9   l(3)dsl-9 (Cohen, 1993) l(3)dsl9   l(3)SG62   l(3)XII-10 (Gatti and Baker, 1989, Ripoll et al., 1987) lqfR (Lee et al., 2009, Wasbrough et al., 2010) LqfR (Lee et al., 2006, Benhra et al., 2011) XII-10
Name Synonym	CG31285   epsin-2 (Lloyd et al., 2000, ) epsin-like (FlyBase Genome Annotators, 2008) lethal (3) SG62   Liquid facet related (Benhra et al., 2011) liquid facets-Related (Lee et al., 2009) Liquid facets Related (Lee et al., 2006)
Secondary FlyBase IDs
	FBgn0002502 FBgn0004730 FBgn0010810 FBgn0038962 FBgn0038963 FBgn0040224 FBgn0042645 FBgn0051170 FBgn0051285 FBgn0259107
References ( 41 )
Generate a list of	All references relating to this gene ( 41 )
List References by type	Research paper  ( 9 ) Supplementary material  ( 3 ) Review  ( 3 ) Personal communication to FlyBase  ( 12 ) Abstract  ( 1 ) FlyBase analysis  ( 5 ) Patent  ( 1 ) DNA/RNA sequence record  ( 2 ) Computer file  ( 4 ) Book  ( 1 )
Recent research papers ( 3 )
	Benhra et al., 2011, Curr. Biol. 21(1): 87--95 AP-1 Controls the Trafficking of Notch and Sanpodo toward E-Cadherin Junctions in Sensory Organ Precursors. [FBrf0212697] Burgess et al., 2011, Mol. Biol. Cell 22(12): 2094--2105 AP-1 and clathrin are essential for secretory granule biogenesis in Drosophila. [FBrf0213890] Wendler et al., 2010, EMBO J. 29(2): 304--314 A genome-wide RNA interference screen identifies two novel components of the metazoan secretory pathway. [FBrf0209739] Show all research papers ...
Recent reviews (0)
	All reviews listed in FlyBase were published before 2010 Show reviews ...