FlyBase Gene Report: Dmel\SREBP

General Information

Symbol

Dmel\SREBP

Species

D. melanogaster

Name

Sterol regulatory element binding protein

Annotation Symbol

CG8522

Feature Type

protein_coding_gene

FlyBase ID

FBgn0261283

Gene Model Status

Current

Stock Availability

34 publicly available

Gene Summary

Sterol regulatory element binding protein (SREBP) encodes a membrane protein that functions as a master-regulator of lipogenesis. It activates transcription of lipogenic genes upon reduction of lipid or cholesterol levels. [Date last reviewed: 2019-02-28] (FlyBase Gene Snapshot)

All Summaries

Gene Snapshot
Alliance
Auto summary
Gene Group
Interactive Fly

Also Known As

HLH106, dSREBP, SREBF1, l(3)76BDw, Helix loop helix protein 106

Key Links

Genomic Location

Cytogenetic map

Sequence location

3L:19,793,935..19,798,979 [+]

Recombination map

3-46

RefSeq locus

NT_037436 REGION:19793935..19798979

Sequence

Get Decorated FASTA

Genomic Maps

JBrowse GBrowse

Help me choose

Other Genome Views

The following external sites may use different assemblies or annotations than FlyBase.

Function

GO Summary Ribbons

Gene Ontology (GO) Annotations (16 terms)

Molecular Function (4 terms)

Terms Based on Experimental Evidence (1 term)

CV Term

Evidence

References

enables DNA-binding transcription activator activity, RNA polymerase II-specific

inferred from direct assay

(Rosenfeld and Osborne, 1998)

Terms Based on Predictions or Assertions (3 terms)

CV Term

Evidence

References

enables DNA-binding transcription factor activity, RNA polymerase II-specific

inferred from biological aspect of ancestor with PANTHER:PTN002488844

(assigned by GO_Central )

(Gaudet et al., 2011)

enables protein dimerization activity

inferred from electronic annotation with InterPro:IPR011598

(assigned by InterPro )

(FlyBase Curators et al., 2004-)

enables RNA polymerase II cis-regulatory region sequence-specific DNA binding

inferred from biological aspect of ancestor with PANTHER:PTN002488844

(assigned by GO_Central )

(Gaudet et al., 2011)

Biological Process (8 terms)

Terms Based on Experimental Evidence (4 terms)

CV Term

Evidence

References

involved_in cell morphogenesis

inferred from mutant phenotype

(D'Ambrosio and Vale, 2010)

involved_in fatty acid homeostasis

inferred from mutant phenotype

(Kunte et al., 2006)

involved_in regulation of autophagy of mitochondrion

inferred from mutant phenotype

(Ivatt et al., 2014)

involved_in SREBP signaling pathway

inferred from direct assay

(Rosenfeld and Osborne, 1998)

Terms Based on Predictions or Assertions (4 terms)

CV Term

Evidence

References

involved_in fatty acid biosynthetic process

non-traceable author statement

(Nohturfft and Losick, 2002)

involved_in positive regulation of transcription, DNA-templated

traceable author statement

(Rawson, 2003)

involved_in regulation of fatty acid biosynthetic process

traceable author statement

(Rawson, 2003)

involved_in regulation of transcription by RNA polymerase II

inferred from biological aspect of ancestor with PANTHER:PTN002488844

(assigned by GO_Central )

(Gaudet et al., 2011)

Cellular Component (4 terms)

Terms Based on Experimental Evidence (4 terms)

CV Term

Evidence

References

located_in endoplasmic reticulum membrane

inferred from direct assay

(Rosenfeld and Osborne, 1998)

located_in membrane

inferred from direct assay

(Theopold et al., 1996)

located_in nuclear membrane

inferred from direct assay

(Rosenfeld and Osborne, 1998)

located_in nucleus

inferred from direct assay

(Rosenfeld and Osborne, 1998)

Terms Based on Predictions or Assertions (1 term)

CV Term

Evidence

References

is_active_in nucleus

inferred from biological aspect of ancestor with PANTHER:PTN002488844

(assigned by GO_Central )

(Gaudet et al., 2011)

located_in nucleus

traceable author statement

(Rawson, 2003)

Gene Group (FlyBase)

BASIC HELIX-LOOP-HELIX TRANSCRIPTION FACTORS

Protein Family (UniProt)

Protein Signatures (InterPro)

Summaries

Gene Snapshot

Gene Group (FlyBase)

BASIC HELIX-LOOP-HELIX TRANSCRIPTION FACTORS -: Basic helix-loop-helix (bHLH) transcription factors are sequence-specific DNA-binding proteins that regulate transcription. They are characterized by a 60 amino acid region comprising a basic DNA binding domain followed by a HLH motif formed from two amphipathic α-helices connected by a loop. bHLH transcription factors form homo- and hetero-dimeric complexes, which bind to a E box consensus sequence. (Adapted from PMID:15186484).

Summary (Interactive Fly)

bHLH-leucine zipper transcription factor - membrane bound HLH106 is released by phosphatidylethanolamine, exerting feedback control on the synthesis of fatty acids and phospholipids - cleavage by Drice releases an SREBP fragment to travel to the nucleus where it mediates the increased transcription of target genes needed for lipid synthesis and uptake

Interactive Fly

Gene Model and Products

Number of Transcripts

Number of Unique Polypeptides

Please see the JBrowse view of Dmel\SREBP for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)

Isoform displayed:

Pfam protein domains

InterPro name

classification

start

end

Protein Domains (via SMART)

Isoform displayed:

SMART protein domains

InterPro name

classification

start

end

Structure New Section

Protein 3D structure (Predicted by AlphaFold) (AlphaFold entry Q9VW37)

If you don't see the viewer to the right, refresh your browser.

Model Confidence:

Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Comments on Gene Model

Low-frequency RNA-Seq exon junction(s) not annotated.

Annotated transcripts do not represent all supported alternative splices within 5' UTR.

Gene model reviewed during 5.46

Sequence Ontology: Class of Gene

gene

(Cook, 2008.12.1)

nuclear_gene

protein_coding_gene

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Assoc. CDS (aa)

SREBP-RA

FBtr0074873

NM_168815

3841

1113

SREBP-RB

FBtr0074874

NM_168816

3951

1113

SREBP-RC

FBtr0074875

NM_079442

3818

1113

SREBP-RD

FBtr0333877

NM_001275135

3920

1113

Additional Transcript Data and Comments

Reported size (kB)

3.8 (northern blot)

(Theopold et al., 1996)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kDa)

Length (aa)

Theoretical pI

UniProt

RefSeq ID

GenBank

SREBP-PA

FBpp0074642

124.5

1113

7.75

FBpp0074643

124.5

1113

7.75

FBpp0074644

124.5

1113

7.75

FBpp0306009

124.5

1113

7.75

Q9VW37

NP_001262064

AGB94757

Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

1113 aa isoforms: SREBP-PA, SREBP-PB, SREBP-PC, SREBP-PD

Additional Polypeptide Data and Comments

Reported size (kDa)

1113 (aa); 130, 85 (kD observed); 125 (kD predicted)

(Theopold et al., 1996)

Comments

External Data

Crossreferences

InterPro - A database of protein families, domains and functional sites

Linkouts

Sequences Consistent with the Gene Model

Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\SREBP using the Feature Mapper tool.

External Data

Crossreferences

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

HLH106_1

Linkouts

Expression Data

Expression Summary Ribbons

Colored tiles in ribbon indicate that the Fly Cell Atlas project found the gene expressed in that cell type. Darker colors mean that more cells of that cell type express the gene:

low

high

Colorless tiles indicate that there is no scRNAseq data for the gene in that cell type.

Colored tiles in ribbon indicate that expression data (RNA and/or protein) has been curated by FlyBase for that anatomical location. Colorless tiles indicate that there is no curated data for that location.

Colored tiles in the ribbon indicate the average RNA expression level of the gene at the indicated stages:

low

high

as determined by RNA-seq (RPKM) using whole organism samples modENCODE, Brown et al., 2014. For complete stage-specific expression data, view the modENCODE Development RNA-Seq section under High-Throughput Expression below.

Transcript Expression

in situ

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage 1 -- 3

organism

Comment: maternally deposited

(Fisher et al., 2012)

embryonic stage 11 -- 12

Malpighian tubule primordium

(Fisher et al., 2012)

midgut interstitial cell primordium

(Fisher et al., 2012)

posterior midgut primordium

(Fisher et al., 2012)

northern blot

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage -- adult stage

(Theopold et al., 1996)

RT-PCR

Stage

Tissue/Position (including subcellular localization)

Reference

third instar larval stage

embryonic/larval fat body

(Suh et al., 2006)

Additional Descriptive Data

SREBP transcripts are expressed throughout development.

(Theopold et al., 1996)

Marker for

fat body

(Suh et al., 2006)

Subcellular Localization

CV Term

Polypeptide Expression

mass spectroscopy

Stage

Tissue/Position (including subcellular localization)

Reference

adult stage

adult head

• membrane

(Aradska et al., 2015)

western blot

Stage

Tissue/Position (including subcellular localization)

Reference

adult stage

retina

(Tsai et al., 2019)

Additional Descriptive Data

Both the full-length precursor and the activated, nuclear forms of SREBP are detected in the retina.

(Tsai et al., 2019)

Marker for

Subcellular Localization

CV Term

Evidence

References

located_in endoplasmic reticulum membrane

inferred from direct assay

(Rosenfeld and Osborne, 1998)

located_in membrane

inferred from direct assay

(Theopold et al., 1996)

located_in nuclear membrane

inferred from direct assay

(Rosenfeld and Osborne, 1998)

located_in nucleus

inferred from direct assay

(Rosenfeld and Osborne, 1998)

Expression Deduced from Reporters

Reporter: PBac{GAL4D,EYFP}SREBP⁵²

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage 17

organism | segmentally repeated

(Horn et al., 2003)

first instar larval stage -- third instar larval stage

embryonic/larval midgut

(Kunte et al., 2006)

embryonic/larval oenocyte

(Kunte et al., 2006)

first instar larval stage -- prepupal stage P4

embryonic/larval fat body

(Kunte et al., 2006)

third instar larval stage

embryonic/larval anterior midgut

(Kunte et al., 2006)

embryonic/larval posterior midgut | faint

(Kunte et al., 2006)

wandering third instar larval stage

embryonic/larval corpus allatum

(Kunte et al., 2006)

pharate adult stage P8 -- P15

organism

(Kunte et al., 2006)

adult stage

adult oenocyte

(Kunte et al., 2006)

adult proventriculus

(Kunte et al., 2006)

adult stage | male

ejaculatory bulb

(Kunte et al., 2006)

High-Throughput Expression Data

Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\SREBP in GBrowse 2

RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region

View exonic expression by developmental stage for Dmel\SREBP

View exonic expression by tissue for Dmel\SREBP

Bulk Downloads

RNA-Seq RPKM values for all genes

Reference

See Gelbart and Emmert, 2013 for analysis details and data files for all genes.

Developmental Proteome: Life Cycle

Developmental Proteome: Embryogenesis

External Data and Images

Linkouts

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0261283

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

40155/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0261283

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0015234

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0261283

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG8522

Flygut - An atlas of the Drosophila adult midgut

FBgn0261283

Images

FlyBase Wiki

Image Based Resources

Alleles, Insertions, Transgenic Constructs, and Aberrations

Classical and Insertion Alleles ( 10 )

For All Classical and Insertion Alleles Show

Other relevant insertions

Transgenic Constructs ( 28 )

For All Alleles Carried on Transgenic Constructs Show

Transgenic constructs containing/affecting coding region of SREBP

Transgenic constructs containing regulatory region of SREBP

Aberrations (Deficiencies and Duplications) ( 28 )

Inferred from experimentation ( 28 )

Gene not disrupted in

Gene disrupted in

Gene partially disrupted in

Df(3L)HLH106¹⁸⁹

(Kunte et al., 2006)

Inferred from location ( 0 )

Alleles Representing Disease-Implicated Variants

Phenotypes

For more details about a specific phenotype click on the relevant allele symbol.

Lethality

Allele

lethal

lethal (with Df(3L)ED228)

SREBP¹⁸⁹

lethal (with Df(3L)kto2)

lethal (with SREBP⁵²)

SREBP¹⁸⁹

lethal (with SREBP¹⁸⁹)

SREBP⁵²

lethal | heat sensitive, with Scer\GAL4^Bx-MS1096

SREBP^Cdel.UAS

lethal | larval stage, with Scer\GAL4^da.G32

SREBP^dsRNA.UAS

lethal | pupal stage, with Scer\GAL4^da.G32

SREBP^dsRNA.UAS

lethal | recessive

lethal - all die before end of second instar larval stage | recessive

partially lethal - majority live | conditional

SREBP¹⁸⁹

viable, with Dcr-2^UAS.cDa, Scer\GAL4^elav.PLu

SREBP^GD4360

viable, with Scer\GAL4^Mef2.PR

SREBP^GD4360

viable, with Scer\GAL4^pnr-MD237

SREBP^GD4360

viable, with Scer\GAL4^tin.CΔ4

SREBP^GD4360

viable | conditional

SREBP¹⁸⁹

Other Phenotypes

Allele

abnormal developmental rate, with Scer\GAL4^da.G32

SREBP^dsRNA.UAS

abnormal neuroanatomy | adult stage, with Scer\GAL4^ninaE.PT

SREBP^1-452.UAS

abnormal neuroanatomy | adult stage | somatic clone

SREBP¹⁸⁹

abnormal neuroanatomy | adult stage | somatic clone, with Scer\GAL4^{DIP-γ-MI03222-GAL4}

SREBP^CA.UAS.cUa

abnormal size | adult stage, with Scer\GAL4^ninaE.PT

SREBP^1-452.UAS

abnormal size | adult stage, with Scer\GAL4^NP0001

decreased body size, with Scer\GAL4^da.G32

SREBP^dsRNA.UAS

decreased body size | recessive | second instar larval stage

SREBP¹⁸⁹

decreased cell size, with Scer\GAL4^en-e16E

SREBP^dsRNA.UAS

some die during second instar larval stage | recessive

visible, with Scer\GAL4^Bx-MS1096

visible, with Scer\GAL4^en-e16E

SREBP^dsRNA.UAS

Phenotype manifest in

Allele

adult heart, with Scer\GAL4^HCH.Hand

adult heart ventral longitudinal muscle cell, with Scer\GAL4^HCH.Hand

SREBP^Cdel.UAS

adult midgut, with Scer\GAL4^NP0001

adult optic lobe glial cell | cell non-autonomous, with Scer\GAL4^nSyb.PS

SREBP^UAS.cKa

axon | adult stage, with Scer\GAL4^ninaE.PT

SREBP^1-452.UAS

capitate projection | adult stage, with Scer\GAL4^ninaE.PT

SREBP^1-452.UAS

dendrite | adult stage | somatic clone

SREBP¹⁸⁹

dendrite | adult stage | somatic clone, with Scer\GAL4^{DIP-γ-MI03222-GAL4}

SREBP^CA.UAS.cUa

dense core granule | adult stage, with Scer\GAL4^ninaE.PT

SREBP^1-452.UAS

distal medullary amacrine neuron Dm8 | adult stage | somatic clone

SREBP¹⁸⁹

distal medullary amacrine neuron Dm8 | adult stage | somatic clone, with Scer\GAL4^{DIP-γ-MI03222-GAL4}

SREBP^CA.UAS.cUa

eye photoreceptor cell | adult stage, with Scer\GAL4^ninaE.PT

SREBP^1-452.UAS

lipid droplet | adult stage, with Scer\GAL4^NP0001

lipid droplet | adult stage | cell non-autonomous, with Scer\GAL4^nSyb.PS

SREBP^UAS.cKa

neuronal cell body | adult stage, with Scer\GAL4^ninaE.PT

SREBP^1-452.UAS

optic cartridge | adult stage, with Scer\GAL4^ninaE.PT

SREBP^1-452.UAS

synaptic vesicle | adult stage, with Scer\GAL4^ninaE.PT

SREBP^1-452.UAS

T-bar | adult stage, with Scer\GAL4^ninaE.PT

SREBP^1-452.UAS

wing, with Scer\GAL4^Bx-MS1096

wing, with Scer\GAL4^da.G32

SREBP^dsRNA.UAS

wing blade posterior compartment, with Scer\GAL4^en-e16E

SREBP^dsRNA.UAS

Orthologs

Downloads

Download All DIOPT Orthologs

Human Orthologs (via DIOPT v8.0)

Homo sapiens (Human) (7)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Hsap\SREBF2

13 of 15

Yes

Hsap\SREBF1

12 of 15

Yes

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

Model Organism Orthologs (via DIOPT v8.0)

Mus musculus (laboratory mouse) (8)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Mmus\Srebf2

13 of 15

Yes

Mmus\Srebf1

12 of 15

Yes

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

Rattus norvegicus (Norway rat) (3)

Rnor\Srebf1

12 of 13

Yes

Rnor\Srebf2

11 of 13

Yes

Rnor\Mycs

1 of 13

Yes

Xenopus tropicalis (Western clawed frog) (3)

Xtro\srebf2

8 of 12

Yes

Xtro\srebf1

7 of 12

Yes

Xtro\mycn

1 of 12

Yes

Danio rerio (Zebrafish) (8)

Drer\srebf2

12 of 15

Yes

Drer\srebf1

8 of 15

Yes

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

Caenorhabditis elegans (Nematode, roundworm) (2)

Cele\sbp-1

14 of 15

Yes

Cele\hlh-30

1 of 15

Arabidopsis thaliana (thale-cress) (0)

No records found.

Saccharomyces cerevisiae (Brewer's yeast) (3)

Scer\HMS1

3 of 15

Yes

Scer\RTG3

1 of 15

Scer\TYE7

1 of 15

Yes

Schizosaccharomyces pombe (Fission yeast) (3)

Spom\sre2

3 of 12

Yes

Spom\sre1

2 of 12

Yes

Spom\SPAC3F10.12c

1 of 12

Other Organism Orthologs (via OrthoDB)

Paralogs

Downloads

Download All DIOPT Paralogs

Paralogs (via DIOPT v8.0)

Drosophila melanogaster (Fruit fly) (2)

Gene Symbol

Score

Source

Alignment

1 of 10

Usf

1 of 10

Human Disease Associations

FlyBase Human Disease Model Reports

Disease Model Summary Ribbon

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 2 )

Allele

Disease

Evidence

References

SREBP^Cdel.UAS

model of heart conduction disease

CEA with SREBP^UAS.Exel

(Lim et al., 2011)

SREBP^UAS.Exel

model of heart conduction disease

CEA with SREBP^Cdel.UAS

(Lim et al., 2011)

Potential Models Based on Orthology ( 0 )

Human Ortholog

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 2 )

Allele

Disease

Interaction

References

SREBP⁵²

ameliorates heart conduction disease

modeled by eas²

(Lim et al., 2011)

SREBP¹⁸⁹

ameliorates heart conduction disease

modeled by eas²

(Lim et al., 2011)

Disease Associations of Human Orthologs (via DIOPT v8.0 and OMIM)

Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.

Homo sapiens (Human)

Gene name

Score

OMIM

OMIM Phenotype

DO term

Complementation?

Transgene?

SREBF2; sterol regulatory element binding transcription factor 2

13 of 15

600481

SREBF1; sterol regulatory element binding transcription factor 1

12 of 15

184756

Functional Complementation Data

Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.

Interactions

Summary of Physical Interactions

esyN Network Diagram

Interactions Browser

View in Interactions Browser

Please see the Physical Interaction reports below for full details

protein-protein

Physical Interaction

Assay

References

SREBP - lms

two hybrid array

(Shokri et al., 2019)

Summary of Genetic Interactions

esyN Network Diagram

esyN Network Key:

Suppression

Enhancement

View in Interactions Browser

Please look at the allele data for full details of the genetic interactions

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

suppressible

(Liu et al., 2017)

suppressible

(Liu et al., 2017)

suppressible

(Liu et al., 2017)

suppressible

(Liu et al., 2017)

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

suppressible

(Lim et al., 2011)

suppressible

(Lyu et al., 2021)

enhanceable

(Amarneh et al., 2009)

Tor

suppressible

SREBP

(Luo et al., 2020)

External Data

Linkouts

BioGRID - A database of protein and genetic interactions.

65424

DroID - A comprehensive database of gene and protein interactions.

FBgn0261283

MIST (protein-protein) - An integrated Molecular Interaction Database

SREBP

Pathways

Signaling Pathways (FlyBase)

Metabolic Pathways

FlyMet - A comprehensive tissue-specific metabolomics resource for Drosophila.

FBgn0261283

External Data

Linkouts

Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.

Regulation of cholesterol biosynthesis by SREBP (SREBF)

Genomic Location and Detailed Mapping Data

Chromosome (arm)

Recombination map

3-46

Cytogenetic map

76C5-76C6

Sequence location

3L:19,793,935..19,798,979 [+]

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

76C5-76C6

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

Experimentally Determined Recombination Data

Location

3-46

(FlyBase, 2016)

3-43.1

(Comeron et al., 2012)

(Horn et al., 2003)

Left of (cM)

Right of (cM)

Notes

Stocks and Reagents

Stocks (34)

Aberrations including deletions of this gene Aberrations including duplications of this gene

Bloomington

41017

P{UAS-SREBP.1-452}1, w^*

25975

y¹ v¹; P{TRiP.JF01997}attP2

8236

y¹ w¹¹¹⁸; P{UAS-SREBP.Exel}3

8237

P{UAS-SREBP.Exel}1, y¹ w¹¹¹⁸

8238

P{UAS-SREBP.Ndel}1, y¹ w¹¹¹⁸

8239

y¹ w¹¹¹⁸; P{UAS-SREBP.Ndel}2

8243

P{UAS-SREBP.Cdel}1, y¹ w¹¹¹⁸

FlyORF

F001654

M{UAS-SREBP.ORF}ZH-86Fb

F001233

M{UAS-SREBP.ORF.3xHA}ZH-86Fb

F000683

M{UAS-SREBP.ORF.3xHA.GW}ZH-86Fb

VDRC

v37640

w¹¹¹⁸; P{GD4360}v37640

v37641

w¹¹¹⁸; P{GD4360}v37641

More stocks available...

Genomic Clones (13)

Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

cDNA Clones (36)

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequenced

BDGP DGC clones

LP12374

Other clones

Drosophila Genomics Resource Center cDNA clones

For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

FBgn0261283

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

Other clones

RNAi and Array Information

Linkouts

DRSC - Results frm RNAi screens

FBgn0261283

GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents

40155

Antibody Information

Laboratory Generated Antibodies

polyclonal

(Xie et al., 2015)

Commercially Available Antibodies

Other Information

Relationship to Other Genes

Source for database identify of

Source for identity of: SREBP HLH106

(FlyBase, 2009-)

Source for database merge of

Source for merge of: HLH106 l(3)76BDw

(Kennison, 2009.7.23)

Additional comments

Renamed from 'HLH106' to 'SREBP' to be more informative and reflect clear preference in the literature.

(FlyBase, 2009-)

Other Comments

SREBP mutants exhibit lipid droplet accumulation in glia, but this does not lead to premature neurodegeneration.

(Liu et al., 2015)

S2 cells treated with dsRNA generated against this gene show reduced phagocytosis of Candida albicans compared to untreated cells.

(Stroschein-Stevenson et al., 2006)

RNAi generated by PCR using primers directed to this gene causes a cell growth and viability phenotype when assayed in Kc167 and S2R⁺ cells.

(Boutros et al., 2004)

Phosphatidylethanolamine controls the release of HLH106 protein from cell membranes.

(Dobrosotskaya et al., 2002)

Area matching Drosophila HLH106 gene, Acc. No. U38238.

(Davies, 2001.3.15)

HLH106, a SREBP homolog from Drosophila, has been isolated. The similarity in the domain structure to vertebrate SREBP is a strong argument that the proteins have related functions.

(Theopold et al., 1996)

HLH106 is related to human sterol regulatory protein SREBP-1.

(Ekengren et al., 1995)

Origin and Etymology

Discoverer

Etymology

Identification

External Crossreferences and Linkouts ( 49 )

Sequence Crossreferences

NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.

40155

GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.

GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.

RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.

UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.

Q9VW37

UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information

Other crossreferences

AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.

Q9VW37

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0261283

Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones

FBgn0261283

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

40155/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0261283

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

HLH106_1

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0015234

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0261283

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG8522

Flygut - An atlas of the Drosophila adult midgut

FBgn0261283

FlyMet - A comprehensive tissue-specific metabolomics resource for Drosophila.

FBgn0261283

FlyMine - An integrated database for Drosophila genomics

FBgn0261283

GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents

40155

iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)

TC007163

InterPro - A database of protein families, domains and functional sites

KEGG Genes - Molecular building blocks of life in the genomic space.

Dmel_CG8522

MARRVEL_MODEL - MARRVEL (model organism gene)

40155

modMine - A data warehouse for the modENCODE project

FBgn0261283

Linkouts

BioGRID - A database of protein and genetic interactions.

65424

DroID - A comprehensive database of gene and protein interactions.

FBgn0261283

DRSC - Results frm RNAi screens

FBgn0261283

Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution

Interactive Fly

MIST (protein-protein) - An integrated Molecular Interaction Database

SREBP

Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.

Regulation of cholesterol biosynthesis by SREBP (SREBF)

Synonyms and Secondary IDs (23)

Reported As

Symbol Synonym

CG8522

(Ward and Moehring, 2021, Chiang et al., 2016, Hosono et al., 2015, Kim et al., 2015, Schertel et al., 2013, Ni et al., 2011.7.19, Perkins et al., 2009.1.15, Molnar et al., 2006, Ramet et al., 2002, Seegmiller et al., 2002)

HlH106

(Molnar et al., 2006)

SREBF1

(Wangler et al., 2017, Ivatt and Whitworth, 2014, Ivatt et al., 2014)

SREBP

(Carlson et al., 2022, Charroux and Royet, 2022, Bonfini et al., 2021, Ekure et al., 2021, He et al., 2021, Heier et al., 2021, Jacomin et al., 2021, Kilo et al., 2021, Liu and Han, 2021.4.14, Lyu et al., 2021, Moraes and Montagne, 2021, Pang et al., 2021, Ward and Moehring, 2021, Ågren et al., 2020, Luo et al., 2020, Martínez et al., 2020, Toprak et al., 2020, Zipper et al., 2020, Chen et al., 2019, Mirth et al., 2019, Sênos Demarco et al., 2019, Shokri et al., 2019, Su et al., 2019, Swevers, 2019, Tsai et al., 2019, Westfall et al., 2019, Gene Disruption Project members, 2018-, Lee et al., 2018, Lehmann, 2018, Park et al., 2018, Swevers et al., 2018, Westfall et al., 2018, Yin et al., 2018, Chng et al., 2017, Liu and Jin, 2017, Sieber and Spradling, 2017, Transgenic RNAi Project members, 2017-, Yan et al., 2017, Chiang et al., 2016, Diop and Bodmer, 2015, Diop et al., 2015, Liu et al., 2015, model organism Encyclopedia of Regulatory Network (modERN) Project, 2015-, Sanchez-Alvarez et al., 2015, Schertel et al., 2015, Sieber and Spradling, 2015, Xie et al., 2015, Song et al., 2014, Bonke et al., 2013, Rawson, 2013, Niwa and Niwa, 2011, D'Ambrosio and Vale, 2010, Bauer et al., 2009, Guo et al., 2008, Callejo et al., 2007, Matthews and Rawson, 2007, Cherry et al., 2006, Dorner et al., 2006, Matthews et al., 2006, Suh et al., 2006, Higaki et al., 2004, Kunte et al., 2004, Nohturfft and Losick, 2002)

SREBP1

(Vos and Klein, 2021)

Srebp

(He et al., 2021)

dSrebp

(Montooth et al., 2006)

dsrebp

(Ozdemir and Rawson, 2011, Matthews et al., 2010)

l(3)76BDw

(Cooper et al., 2010, Cook, 2008.12.1)

srebp

(Zhang et al., 2021, Yu et al., 2020, Sundararajan and Miller, 2018, Meltzer et al., 2017, Wei et al., 2017, Belgacem and Martin, 2007)

Name Synonyms

Drosophila sterol regulatory element binding protein

(Montooth et al., 2006)

Helix loop helix protein 106

(Ekengren et al., 1995)

Sterol Regulatory Element Binding Protein

(Matthews et al., 2010)

Sterol regulatory element binding protein

(Liu et al., 2015)

Sterol regulatory element-binding protein

(Dobrosotskaya et al., 2002)

lethal (3) 76BDw

sterol regulatory element binding protein

(Diop and Bodmer, 2015)

sterol regulatory element-binding protein

(D'Ambrosio and Vale, 2010)

sterol response element binding protein

(Sundararajan and Miller, 2018)

sterol-responsive element-binding protein

(Bauer et al., 2009)

transcription factor Sterol regulatory element binding protein

(Bonke et al., 2013)

Secondary FlyBase IDs

FBgn0015234
FBgn0063456
FBgn0260652

Datasets (0)

Study focus (0)

Experimental Role

Project

Project Type

Title

Study result (0)

Result

Result Type

Title

References (177)

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