Gene: Dmel\SREBP
HLH106, dSREBP, SREBF1, l(3)76BDw, Helix loop helix protein 106
bHLH-leucine zipper transcription factor - membrane bound HLH106 is released by phosphatidylethanolamine, exerting feedback control on the synthesis of fatty acids and phospholipids - cleavage by Drice releases an SREBP fragment to travel to the nucleus where it mediates the increased transcription of target genes needed for lipid synthesis and uptake
Please see the JBrowse view of Dmel\SREBP for information on other features
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Low-frequency RNA-Seq exon junction(s) not annotated.
Annotated transcripts do not represent all supported alternative splices within 5' UTR.
Gene model reviewed during 5.46
3.8 (northern blot)
1113 (aa); 130, 85 (kD observed); 125 (kD predicted)
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\SREBP using the Feature Mapper tool.
Comment: maternally deposited
SREBP transcripts are expressed throughout development.
Both the full-length precursor and the activated, nuclear forms of SREBP are detected in the retina.
GBrowse - Visual display of RNA-Seq signals
View Dmel\SREBP in GBrowse 2Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
Source for identity of: SREBP HLH106
Source for merge of: HLH106 l(3)76BDw
Renamed from 'HLH106' to 'SREBP' to be more informative and reflect clear preference in the literature.
SREBP mutants exhibit lipid droplet accumulation in glia, but this does not lead to premature neurodegeneration.
S2 cells treated with dsRNA generated against this gene show reduced phagocytosis of Candida albicans compared to untreated cells.
RNAi generated by PCR using primers directed to this gene causes a cell growth and viability phenotype when assayed in Kc167 and S2R+ cells.
Phosphatidylethanolamine controls the release of HLH106 protein from cell membranes.
Area matching Drosophila HLH106 gene, Acc. No. U38238.
HLH106, a SREBP homolog from Drosophila, has been isolated. The similarity in the domain structure to vertebrate SREBP is a strong argument that the proteins have related functions.
HLH106 is related to human sterol regulatory protein SREBP-1.
