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Gene Dmel\HLH106

General Information
Symbol	Dmel\HLH106	Species	D. melanogaster
Name	Helix loop helix protein 106	Annotation symbol	CG8522
Feature type	protein_coding_gene	FlyBase ID	FBgn0261283
Gene Model Status	Current	Stock availability	19 publicly available
Also Known As	dSREBP, SREBP, l(3)76BDw
Genomic Location
Chromosome (arm)	3L	Recombination map	3-
Cytogenetic map	76C5-76C6	Sequence location	3L:19,787,044..19,792,086 [+]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents modENCODE GBrowse	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene Helix loop helix protein 106 is referred to in FlyBase by the symbol Dmel\HLH106 (CG8522, FBgn0261283). It is a protein_coding_gene from Drosophila melanogaster. There is experimental evidence that it has the molecular function: RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription. There is experimental evidence that it is involved in the biological process: fatty acid homeostasis; cell morphogenesis; positive regulation of transcription via sterol regulatory element binding involved in ER-nuclear sterol response pathway; phagocytosis, engulfment. 31 alleles are reported. The phenotypes of these alleles are annotated with: adult heart; ventral adult heart longitudinal muscle; wing. It has 3 annotated transcripts and 3 annotated polypeptides. Protein features are: Helix-loop-helix DNA-binding. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of low expression. Peak expression observed within 00-06 and 18-24 hour embryonic stages, during early larval stages, at stages throughout the pupal period, in stages of adults of both sexes. Summary of FlyAtlas Anatomical Expression Data: Nearly all larval and adult organs/tissues expressed at moderate or high levels. Expression at high levels in the following post-embryonic organs or tissues: adult eye, adult crop, adult heart, adult fat body, virgin spermatheca, adult carcass. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, larval/adult central nervous system, larval/adult midgut, larval/adult hindgut, larval/adult Malpighian tubules, larval fat body, larval/adult salivary gland, larval trachea, adult female reproductive system, adult male accessory gland, larval carcass. Comments on Affy2 ProbeSet: ProbeSet 1628292_s_at completely aligns to an exonic region common to each of the 3 FlyBase-annotated transcript isoforms of HLH106. Gene sequence location is 3L:19787044..19792086.
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2011_10
FB2012_01	References Belgacem and Martin, 2007, PLoS ONE 2: D'Ambrosio and Vale, 2010, J. Cell Biol. 191(3): 471--478 Sequence features HFA11182 BKN22813 Controlled Vocabulary Terms cell morphogenesis nuclear membrane positive regulation of transcription via sterol regulatory element binding involved in ER-nuclear sterol response pathway endoplasmic reticulum membrane RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 76C5-76C6
Experimentally Determined Cytological Location
Cytogenetic map Notes References
Experimentally Determined Recombination Data
Location	3- (Horn et al., 2003)
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\HLH106 for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) HLH106-RA FBtr0074873  NM_168815   3839   1113 HLH106-RB FBtr0074874  NM_168816   3949   1113 HLH106-RC FBtr0074875  NM_079442   3813   1113
Additional Transcript Data & Comments
Reported size (kB)	3.8 (northern blot) (Theopold et al., 1996)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein HLH106-PA   FBpp0074642   124.5   1113   7.75     NP_730449   AAF49115 HLH106-PB   FBpp0074643   124.5   1113   7.75     NP_730450   AAN11631 HLH106-PC   FBpp0074644   124.5   1113   7.75     NP_524166   AAN11632
Additional Polypeptide Data & Comments
Reported size (kDa)	1113 (aa); 130, 85 (kD observed); 125 (kD predicted) (Theopold et al., 1996)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Helix-loop-helix DNA-binding (IPR011598)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA201358   AA567826   AE014296 AAF49115   AE014296 AAN11631   AE014296 AAN11632   AI107040   AI114160   AI297927   AI533148   AI533491   AX093934   BG632285   BI234644   BI608839   BI612592   BI631776   BI633653   BI637176   BI637795   BI639237   BI639253   BI641615   BP560338   BT010285 AAQ23603   CA803867   CO154065   CO177521   CO272214   CO294296   CO304709   CO309792   CZ468591   CZ476030   EC057351   EC064548   EC069305   EC075954   EC194521   EC207098   EC212768   EC230015   EC249048   EC260930   EC263583   ES692329   GH942681   GH942937   GH942958   GH945013   GH950185   GH950375   GH951680   GH968335   GH968582   GH979167   GH985036   U38238 AAA97864
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL	Q24146 Q9VW37
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
northern blot Stage Tissue/Position (including subcellular localization) Reference embryonic stage -- adult stage     (Theopold et al., 1996)
Additional Descriptive Data
	HLH106 transcripts are expressed throughout development. (Theopold et al., 1996)
Marker for
Subcellular Localization
CV Term
Notes
Polypeptide Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term	plasma membrane nucleus (Theopold et al., 1996)
Notes
High-Throughput Expression Data
or
See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes. modENCODE Temporal Expression Data for FBgn0261283    Styles Linear Logarithmic Heatmap    Scales max expr for FBgn0261283 Very low expression bin max Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of low expression. Peak expression observed within 00-06 and 18-24 hour embryonic stages, during early larval stages, at stages throughout the pupal period, in stages of adults of both sexes. [download data (TSV)] Guide to modENCODE expression level colors   No expression (0 - 0)   Extremely low expression (1 - 10)   Very low expression (11 - 100)   Low expression (101 - 400)   Moderate expression (401 - 1400)   Moderately high expression (1401 - 4000)   High expression (4001 - 10000)   Very high expression (10001 - 100000)   Extremely high expression (100001 - 2000000) Linear, scaled to maximum FBgn0261283 expression level Developmental Stage   Expression Level embryo 00-02hr    4696 embryo 02-04hr    264 embryo 04-06hr    264 embryo 06-08hr    381 embryo 08-10hr    826 embryo 10-12hr    2951 embryo 12-14hr    2869 embryo 14-16hr    3710 embryo 16-18hr    3329 embryo 18-20hr    5053 embryo 20-22hr    4696 embryo 22-24hr    4525 larva L1    6995 larva L2    5248 larva L3 12hr old    5141 larva L3 puffstage 1-2    3255 larva L3 puffstage 3-6    3241 larva L3 puffstage 7-9    2972 white prepupae new    3116 white prepupae 12hr    4192 white prepupae 24hr    3633 pupae 2d postWPP    2782 pupae 3d postWPP    2597 pupae 4d postWPP    4086 adult male 01day    5204 adult male 05day    6044 adult male 30day    7016 adult female 01day    6163 adult female 05day    5306 adult female 30day    5647 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High  Linear, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (4696) embryo 02-04hr  (264) embryo 04-06hr  (264) embryo 06-08hr  (381) embryo 08-10hr  (826) embryo 10-12hr  (2951) embryo 12-14hr  (2869) embryo 14-16hr  (3710) embryo 16-18hr  (3329) embryo 18-20hr  (5053) embryo 20-22hr  (4696) embryo 22-24hr  (4525) larva L1  (6995) larva L2  (5248) larva L3 12hr old  (5141) larva L3 puffstage 1-2  (3255) larva L3 puffstage 3-6  (3241) larva L3 puffstage 7-9  (2972) white prepupae new  (3116) white prepupae 12hr  (4192) white prepupae 24hr  (3633) pupae 2d postWPP  (2782) pupae 3d postWPP  (2597) pupae 4d postWPP  (4086) adult male 01day  (5204) adult male 05day  (6044) adult male 30day  (7016) adult female 01day  (6163) adult female 05day  (5306) adult female 30day  (5647) Expression Level Scale  None   Extremely low   Very low   Low  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (4696) embryo 02-04hr    264 embryo 04-06hr    264 embryo 06-08hr    381 embryo 08-10hr    826 embryo 10-12hr  (2951) embryo 12-14hr  (2869) embryo 14-16hr  (3710) embryo 16-18hr  (3329) embryo 18-20hr  (5053) embryo 20-22hr  (4696) embryo 22-24hr  (4525) larva L1  (6995) larva L2  (5248) larva L3 12hr old  (5141) larva L3 puffstage 1-2  (3255) larva L3 puffstage 3-6  (3241) larva L3 puffstage 7-9  (2972) white prepupae new  (3116) white prepupae 12hr  (4192) white prepupae 24hr  (3633) pupae 2d postWPP  (2782) pupae 3d postWPP  (2597) pupae 4d postWPP  (4086) adult male 01day  (5204) adult male 05day  (6044) adult male 30day  (7016) adult female 01day  (6163) adult female 05day  (5306) adult female 30day  (5647) Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    4696 embryo 02-04hr    264 embryo 04-06hr    264 embryo 06-08hr    381 embryo 08-10hr    826 embryo 10-12hr    2951 embryo 12-14hr    2869 embryo 14-16hr    3710 embryo 16-18hr    3329 embryo 18-20hr    5053 embryo 20-22hr    4696 embryo 22-24hr    4525 larva L1    6995 larva L2    5248 larva L3 12hr old    5141 larva L3 puffstage 1-2    3255 larva L3 puffstage 3-6    3241 larva L3 puffstage 7-9    2972 white prepupae new    3116 white prepupae 12hr    4192 white prepupae 24hr    3633 pupae 2d postWPP    2782 pupae 3d postWPP    2597 pupae 4d postWPP    4086 adult male 01day    5204 adult male 05day    6044 adult male 30day    7016 adult female 01day    6163 adult female 05day    5306 adult female 30day    5647 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    4696 embryo 02-04hr    264 embryo 04-06hr    264 embryo 06-08hr    381 embryo 08-10hr    826 embryo 10-12hr    2951 embryo 12-14hr    2869 embryo 14-16hr    3710 embryo 16-18hr    3329 embryo 18-20hr    5053 embryo 20-22hr    4696 embryo 22-24hr    4525 larva L1    6995 larva L2    5248 larva L3 12hr old    5141 larva L3 puffstage 1-2    3255 larva L3 puffstage 3-6    3241 larva L3 puffstage 7-9    2972 white prepupae new    3116 white prepupae 12hr    4192 white prepupae 24hr    3633 pupae 2d postWPP    2782 pupae 3d postWPP    2597 pupae 4d postWPP    4086 adult male 01day    5204 adult male 05day    6044 adult male 30day    7016 adult female 01day    6163 adult female 05day    5306 adult female 30day    5647 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  log, scaled to maximum FBgn0261283 expression level Developmental Stage   Expression Level embryo 00-02hr    4696 embryo 02-04hr    264 embryo 04-06hr    264 embryo 06-08hr    381 embryo 08-10hr    826 embryo 10-12hr    2951 embryo 12-14hr    2869 embryo 14-16hr    3710 embryo 16-18hr    3329 embryo 18-20hr    5053 embryo 20-22hr    4696 embryo 22-24hr    4525 larva L1    6995 larva L2    5248 larva L3 12hr old    5141 larva L3 puffstage 1-2    3255 larva L3 puffstage 3-6    3241 larva L3 puffstage 7-9    2972 white prepupae new    3116 white prepupae 12hr    4192 white prepupae 24hr    3633 pupae 2d postWPP    2782 pupae 3d postWPP    2597 pupae 4d postWPP    4086 adult male 01day    5204 adult male 05day    6044 adult male 30day    7016 adult female 01day    6163 adult female 05day    5306 adult female 30day    5647 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (4696) embryo 02-04hr  (264) embryo 04-06hr  (264) embryo 06-08hr  (381) embryo 08-10hr  (826) embryo 10-12hr  (2951) embryo 12-14hr  (2869) embryo 14-16hr  (3710) embryo 16-18hr  (3329) embryo 18-20hr  (5053) embryo 20-22hr  (4696) embryo 22-24hr  (4525) larva L1  (6995) larva L2  (5248) larva L3 12hr old  (5141) larva L3 puffstage 1-2  (3255) larva L3 puffstage 3-6  (3241) larva L3 puffstage 7-9  (2972) white prepupae new  (3116) white prepupae 12hr  (4192) white prepupae 24hr  (3633) pupae 2d postWPP  (2782) pupae 3d postWPP  (2597) pupae 4d postWPP  (4086) adult male 01day  (5204) adult male 05day  (6044) adult male 30day  (7016) adult female 01day  (6163) adult female 05day  (5306) adult female 30day  (5647) Expression Level Scale  None   Extremely low   Very low   Low  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (4696) embryo 02-04hr    264 embryo 04-06hr    264 embryo 06-08hr    381 embryo 08-10hr    826 embryo 10-12hr  (2951) embryo 12-14hr  (2869) embryo 14-16hr  (3710) embryo 16-18hr  (3329) embryo 18-20hr  (5053) embryo 20-22hr  (4696) embryo 22-24hr  (4525) larva L1  (6995) larva L2  (5248) larva L3 12hr old  (5141) larva L3 puffstage 1-2  (3255) larva L3 puffstage 3-6  (3241) larva L3 puffstage 7-9  (2972) white prepupae new  (3116) white prepupae 12hr  (4192) white prepupae 24hr  (3633) pupae 2d postWPP  (2782) pupae 3d postWPP  (2597) pupae 4d postWPP  (4086) adult male 01day  (5204) adult male 05day  (6044) adult male 30day  (7016) adult female 01day  (6163) adult female 05day  (5306) adult female 30day  (5647) Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    4696 embryo 02-04hr    264 embryo 04-06hr    264 embryo 06-08hr    381 embryo 08-10hr    826 embryo 10-12hr    2951 embryo 12-14hr    2869 embryo 14-16hr    3710 embryo 16-18hr    3329 embryo 18-20hr    5053 embryo 20-22hr    4696 embryo 22-24hr    4525 larva L1    6995 larva L2    5248 larva L3 12hr old    5141 larva L3 puffstage 1-2    3255 larva L3 puffstage 3-6    3241 larva L3 puffstage 7-9    2972 white prepupae new    3116 white prepupae 12hr    4192 white prepupae 24hr    3633 pupae 2d postWPP    2782 pupae 3d postWPP    2597 pupae 4d postWPP    4086 adult male 01day    5204 adult male 05day    6044 adult male 30day    7016 adult female 01day    6163 adult female 05day    5306 adult female 30day    5647 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    4696 embryo 02-04hr    264 embryo 04-06hr    264 embryo 06-08hr    381 embryo 08-10hr    826 embryo 10-12hr    2951 embryo 12-14hr    2869 embryo 14-16hr    3710 embryo 16-18hr    3329 embryo 18-20hr    5053 embryo 20-22hr    4696 embryo 22-24hr    4525 larva L1    6995 larva L2    5248 larva L3 12hr old    5141 larva L3 puffstage 1-2    3255 larva L3 puffstage 3-6    3241 larva L3 puffstage 7-9    2972 white prepupae new    3116 white prepupae 12hr    4192 white prepupae 24hr    3633 pupae 2d postWPP    2782 pupae 3d postWPP    2597 pupae 4d postWPP    4086 adult male 01day    5204 adult male 05day    6044 adult male 30day    7016 adult female 01day    6163 adult female 05day    5306 adult female 30day    5647 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     FlyAtlas Anatomical Expression Data for FBgn0261283    Styles Linear Logarithmic Heatmap Back-to-back    Scales max expr for FBgn0261283 Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Nearly all larval and adult organs/tissues expressed at moderate or high levels. Expression at high levels in the following post-embryonic organs or tissues: adult eye, adult crop, adult heart, adult fat body, virgin spermatheca, adult carcass. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, larval/adult central nervous system, larval/adult midgut, larval/adult hindgut, larval/adult Malpighian tubules, larval fat body, larval/adult salivary gland, larval trachea, adult female reproductive system, adult male accessory gland, larval carcass. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (1000 - 25000) Linear, scaled to maximum FBgn0261283 expression level Tissue   Expression Level Larval Central Nervous System    306.05 Larval Midgut    239.4 Larval Hindgut    231.4 Larval Malpighian Tubules    160.2 Larval Fat Body    157.1 Larval Salivary Gland    227.6 Larval Trachea    283.825 Larval Carcass    269.575 Adult Head    328.8 Adult Eye    541.675 Adult Brain    314 Adult Thoracic-Abdominal Ganglion    388 Adult Crop    610.1 Adult Midgut    270 Adult Hindgut    369 Adult Malpighian Tubules    247.6 Adult Fat Body    595.9 Adult Salivary Gland    204.3 Adult Heart    729.925 Adult VirginFemale Spermatheca    669.4 Adult InseminatedFemale Spermatheca    452.5 Adult Ovary    221.9 Adult Testis    60.1 Adult Male Accessory Gland    375.5 Adult Carcass    527 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    306.05 Larval Midgut    239.4 Larval Hindgut    231.4 Larval Malpighian Tubules    160.2 Larval Fat Body    157.1 Larval Salivary Gland    227.6 Larval Trachea    283.825 Larval Carcass    269.575 Adult Head    328.8 Adult Eye  (541.675) Adult Brain    314 Adult Thoracic-Abdominal Ganglion    388 Adult Crop  (610.1) Adult Midgut    270 Adult Hindgut    369 Adult Malpighian Tubules    247.6 Adult Fat Body  (595.9) Adult Salivary Gland    204.3 Adult Heart  (729.925) Adult VirginFemale Spermatheca  (669.4) Adult InseminatedFemale Spermatheca    452.5 Adult Ovary    221.9 Adult Testis    60.1 Adult Male Accessory Gland    375.5 Adult Carcass  527 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    306.05 Larval Midgut    239.4 Larval Hindgut    231.4 Larval Malpighian Tubules    160.2 Larval Fat Body    157.1 Larval Salivary Gland    227.6 Larval Trachea    283.825 Larval Carcass    269.575 Adult Head    328.8 Adult Eye    541.675 Adult Brain    314 Adult Thoracic-Abdominal Ganglion    388 Adult Crop    610.1 Adult Midgut    270 Adult Hindgut    369 Adult Malpighian Tubules    247.6 Adult Fat Body    595.9 Adult Salivary Gland    204.3 Adult Heart    729.925 Adult VirginFemale Spermatheca    669.4 Adult InseminatedFemale Spermatheca    452.5 Adult Ovary    221.9 Adult Testis    60.1 Adult Male Accessory Gland    375.5 Adult Carcass    527 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    306.05 Larval Midgut    239.4 Larval Hindgut    231.4 Larval Malpighian Tubules    160.2 Larval Fat Body    157.1 Larval Salivary Gland    227.6 Larval Trachea    283.825 Larval Carcass    269.575 Adult Head    328.8 Adult Eye    541.675 Adult Brain    314 Adult Thoracic-Abdominal Ganglion    388 Adult Crop    610.1 Adult Midgut    270 Adult Hindgut    369 Adult Malpighian Tubules    247.6 Adult Fat Body    595.9 Adult Salivary Gland    204.3 Adult Heart    729.925 Adult VirginFemale Spermatheca    669.4 Adult InseminatedFemale Spermatheca    452.5 Adult Ovary    221.9 Adult Testis    60.1 Adult Male Accessory Gland    375.5 Adult Carcass    527 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to maximum FBgn0261283 expression level Tissue   Expression Level Larval Central Nervous System    306.05 Larval Midgut    239.4 Larval Hindgut    231.4 Larval Malpighian Tubules    160.2 Larval Fat Body    157.1 Larval Salivary Gland    227.6 Larval Trachea    283.825 Larval Carcass    269.575 Adult Head    328.8 Adult Eye    541.675 Adult Brain    314 Adult Thoracic-Abdominal Ganglion    388 Adult Crop    610.1 Adult Midgut    270 Adult Hindgut    369 Adult Malpighian Tubules    247.6 Adult Fat Body    595.9 Adult Salivary Gland    204.3 Adult Heart    729.925 Adult VirginFemale Spermatheca    669.4 Adult InseminatedFemale Spermatheca    452.5 Adult Ovary    221.9 Adult Testis    60.1 Adult Male Accessory Gland    375.5 Adult Carcass    527 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    306.05 Larval Midgut    239.4 Larval Hindgut    231.4 Larval Malpighian Tubules    160.2 Larval Fat Body    157.1 Larval Salivary Gland    227.6 Larval Trachea    283.825 Larval Carcass    269.575 Adult Head    328.8 Adult Eye  541.675 Adult Brain    314 Adult Thoracic-Abdominal Ganglion    388 Adult Crop  610.1 Adult Midgut    270 Adult Hindgut    369 Adult Malpighian Tubules    247.6 Adult Fat Body  595.9 Adult Salivary Gland    204.3 Adult Heart  729.925 Adult VirginFemale Spermatheca  669.4 Adult InseminatedFemale Spermatheca    452.5 Adult Ovary    221.9 Adult Testis    60.1 Adult Male Accessory Gland    375.5 Adult Carcass  527 Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    306.05 Larval Midgut    239.4 Larval Hindgut    231.4 Larval Malpighian Tubules    160.2 Larval Fat Body    157.1 Larval Salivary Gland    227.6 Larval Trachea    283.825 Larval Carcass    269.575 Adult Head    328.8 Adult Eye    541.675 Adult Brain    314 Adult Thoracic-Abdominal Ganglion    388 Adult Crop    610.1 Adult Midgut    270 Adult Hindgut    369 Adult Malpighian Tubules    247.6 Adult Fat Body    595.9 Adult Salivary Gland    204.3 Adult Heart    729.925 Adult VirginFemale Spermatheca    669.4 Adult InseminatedFemale Spermatheca    452.5 Adult Ovary    221.9 Adult Testis    60.1 Adult Male Accessory Gland    375.5 Adult Carcass    527 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    306.05 Larval Midgut    239.4 Larval Hindgut    231.4 Larval Malpighian Tubules    160.2 Larval Fat Body    157.1 Larval Salivary Gland    227.6 Larval Trachea    283.825 Larval Carcass    269.575 Adult Head    328.8 Adult Eye    541.675 Adult Brain    314 Adult Thoracic-Abdominal Ganglion    388 Adult Crop    610.1 Adult Midgut    270 Adult Hindgut    369 Adult Malpighian Tubules    247.6 Adult Fat Body    595.9 Adult Salivary Gland    204.3 Adult Heart    729.925 Adult VirginFemale Spermatheca    669.4 Adult InseminatedFemale Spermatheca    452.5 Adult Ovary    221.9 Adult Testis    60.1 Adult Male Accessory Gland    375.5 Adult Carcass    527 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    328.8   NA  Eye    541.675   NA  Brain    314   306.05  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    388   NA  Crop    610.1   239.4  Midgut    270   231.4  Hindgut    369   160.2  Malpighian Tubules    247.6   157.1  Fat Body    595.9   227.6  Salivary Gland    204.3   NA  Heart    729.925   283.825  Trachea    NA   NA  VirginFemale Spermatheca    669.4   NA  InseminatedFemale Spermatheca    452.5   NA  Ovary    221.9   NA  Testis    60.1   NA  Male Accessory Gland    375.5   269.575  Carcass    527 modENCODE Temporal Expression Data (Graveley et al., 2011) FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
Expression Clusters
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0261283
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele lethal HLH106189 lethal (with Df(3L)kto2) HLH1061 HLH1062 HLH1063 lethal (with HLH10652) HLH106189 lethal (with HLH106189) HLH10652 lethal | heat sensitive, with Scer\GAL4Bx-MS1096 HLH106Cdel.Scer\UAS lethal | larval stage, with Scer\GAL4da.G32 HLH106dsRNA.Scer\UAS lethal | pupal stage, with Scer\GAL4da.G32 HLH106dsRNA.Scer\UAS lethal | recessive HLH1061 HLH1062 HLH1063 HLH10652 lethal | recessive | second instar larval stage HLH10652 HLH106189 semi-viable | conditional HLH106189 viable, with Scer\GAL4pnr-MD237 HLH106GD4360 viable | conditional HLH106189 Other Phenotypes Allele decreased cell size, with Scer\GAL4en-e16E HLH106dsRNA.Scer\UAS developmental rate defective, with Scer\GAL4da.G32 HLH106dsRNA.Scer\UAS increased cell death HLH106dsRNA.cRa small body, with Scer\GAL4da.G32 HLH106dsRNA.Scer\UAS small body | recessive | second instar larval stage HLH106189 visible, with Scer\GAL4Bx-MS1096 HLH106Cdel.Scer\UAS HLH106dsRNA.Scer\UAS visible, with Scer\GAL4en-e16E HLH106dsRNA.Scer\UAS Phenotype manifest in Allele adult heart, with Scer\GAL4HCH.Hand HLH106Cdel.Scer\UAS HLH106NTdel.Scer\UAS ventral adult heart longitudinal muscle, with Scer\GAL4HCH.Hand HLH106Cdel.Scer\UAS wing, with Scer\GAL4Bx-MS1096 HLH106dsRNA.Scer\UAS HLH106Cdel.Scer\UAS wing, with Scer\GAL4da.G32 HLH106dsRNA.Scer\UAS wing | posterior compartment, with Scer\GAL4en-e16E HLH106dsRNA.Scer\UAS
Classical Alleles ( 8 )
For All Classical Alleles Show
Allele of HLH106 Class Mutagen Stocks Known lesion HLH1061 ethyl methanesulfonate 1 Yes HLH106d08008 P-element activity 1 -- HLH106G8480 P-element activity 1 -- HLH106189 P-element activity 0 Yes HLH1062 ethyl methanesulfonate 0 Yes HLH1063 ethyl methanesulfonate 0 Yes HLH10652 piggyBac transposase 0 Yes HLH106c03318 piggyBac transposase 0 --
Alleles Carried on Transgenic Constructs ( 23 )
For All Alleles Carried on Transgenic Constructs Show
Allele of HLH106 Class Mutagen Stocks Known lesion HLH106Ndel.Scer\UAS in vitro construct - deletion 3 Yes HLH106Scer\UAS.T:Ocun\CYP2C1 antimorphic allele - genetic evidence in vitro construct - coding region fusion 3 Yes HLH106Cdel.Scer\UAS gain of function allele in vitro construct - deletion 2 Yes HLH106GD4360 in vitro construct - RNAi in vitro construct - regulatory fusion 2 Yes HLH106NTdel.Scer\UAS antimorphic allele - genetic evidence in vitro construct - deletion 2 Yes HLH106Scer\UAS.Exel in vitro construct - regulatory fusion 2 Yes HLH106HMS00080 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes HLH106JF01997 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes HLH106+t8.7 in vitro construct - genomic fragment 0 Yes HLH1061-451.Act5C.T:Hsim\gD in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes HLH106Act5C.PR in vitro construct - regulatory fusion 0 Yes HLH106Act5C.T:Hsim\gD in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes HLH106Chit.T:Hsim\gD in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes HLH106D386A in vitro construct - amino acid replacement 0 Yes HLH106dsRNA.cDa in vitro construct - RNAi 0 Yes HLH106dsRNA.cRa in vitro construct - RNAi 0 Yes HLH106dsRNA.cSa in vitro construct - RNAi 0 Yes HLH106dsRNA.Scer\UAS in vitro construct - regulatory fusion in vitro construct - RNAi 0 Yes HLH106N462P.Act5C.T:Hsim\gD in vitro construct - amino acid replacement 0 Yes HLH106NP-FL.Scer\UAS in vitro construct - regulatory fusion in vitro construct - amino acid replacement 0 Yes HLH106R486A.Act5C.T:Hsim\gD in vitro construct - amino acid replacement 0 Yes HLH106Scer\UAS.cKa in vitro construct - regulatory fusion 0 Yes HLH106T:Scer\GAL4,T:Hsim\VP16 in vitro construct 0 Yes
Aneuploid Aberrations
Not disrupted in	Df(3L)25-21 (Cooper et al., 2010) Df(3L)BSC2 (Cooper et al., 2010) Df(3L)BSC20 (Cooper et al., 2010) Df(3L)BSC417 (Cooper et al., 2010) Df(3L)BSC445 (Cooper et al., 2010) Df(3L)ED4799 (Cooper et al., 2010) Df(3L)ED4858 (Cooper et al., 2010) Df(3L)Exel6135 (Cooper et al., 2010) Df(3L)Exel9011 (Cooper et al., 2010) Df(3L)Exel9045 (Cooper et al., 2010) Df(3L)Exel9046 (Cooper et al., 2010) Df(3L)kto22 (Cooper et al., 2010) Df(3L)pipeA13 (Cooper et al., 2010) Df(3L)XS411 (Cooper et al., 2010)
Disrupted in	Df(3L)A23 (Cooper et al., 2010) Df(3L)ash1A16 (Cooper et al., 2010) Df(3L)ED228 (Cooper et al., 2010) Df(3L)Exel9007 (Cooper et al., 2010) Df(3L)Exel9008 (Cooper et al., 2010) Df(3L)Exel9009 (Cooper et al., 2010) Df(3L)kto2 (Cook, 2008.12.1, Cooper et al., 2010) Df(3L)XS533 (Cooper et al., 2010) Df(3L)XS543 (Cooper et al., 2010) Df(3L)XS572 (Cooper et al., 2010) Df(3L)XS705 (Cooper et al., 2010) Df(3L)XS917 (Cooper et al., 2010) Df(3L)XS2182 (Cooper et al., 2010)
Partially disrupted in	Df(3L)HLH106189 (Kunte et al., 2006)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD4360} NA P{TRiP.HMS00080} NA P{TRiP.JF01997} NA P{UAS-HLH106.Cdel} NA P{UAS-HLH106.Exel} NA P{UAS-HLH106.K} NA P{UAS-HLH106.Ndel} NA P{UAS-HLH106.NP-FL} NA P{UAS-HLH106.NTdel} NA P{UAS-HLH106.P450} NA P{UAS-SREBP.RNAi} NA characterization construct P{SREBPg.D386A} NA P{SREBPg.K} NA
Insertions
	Type of insertions Name Expression data miscellaneous insertions PBac{PB}HLH106c03318 NA PBac{y+-attP-9A}VK00021 NA insertion of mobile activating element P{EP}HLH106G8480 NA P{GSV1}EP-PEP-P NA P{XP}HLH106d08008 NA insertion of enhancer trap binary system PBac{GAL4D,EYFP}HLH10652 No
Gene Ontology: Function, Process & Cellular Component ( 12 unique terms )
Terms Based on Experimental Evidence ( 8 terms )
Molecular Function
CV term Evidence References
RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription inferred from direct assay (Rosenfeld and Osborne, 1998)
Biological Process
CV term Evidence References
cell morphogenesis inferred from mutant phenotype (D'Ambrosio and Vale, 2010) fatty acid homeostasis inferred from mutant phenotype (Kunte et al., 2006) phagocytosis, engulfment inferred from mutant phenotype (Stroschein-Stevenson et al., 2006) positive regulation of transcription via sterol regulatory element binding involved in ER-nuclear sterol response pathway inferred from direct assay (Rosenfeld and Osborne, 1998)
Cellular Component
CV term Evidence References
endoplasmic reticulum membrane inferred from direct assay (Rosenfeld and Osborne, 1998) nuclear membrane inferred from direct assay (Rosenfeld and Osborne, 1998) nucleus inferred from direct assay (Rosenfeld and Osborne, 1998)
Terms Based on Predictions or Assertions ( 5 terms )
Molecular Function
CV term Evidence References
sequence-specific DNA binding transcription factor activity inferred from sequence or structural similarity with NCBI_gi:4759168 (FlyBase, 1992-) non-traceable author statement (Hultmark, 1995.10.11)
Biological Process
CV term Evidence References
fatty acid biosynthetic process non-traceable author statement (Nohturfft and Losick, 2002) positive regulation of transcription, DNA-dependent traceable author statement (Rawson, 2003) regulation of fatty acid biosynthetic process traceable author statement (Rawson, 2003)
Cellular Component
CV term Evidence References
nucleus inferred from sequence or structural similarity with NCBI_gi:4759168 (FlyBase, 1992-) non-traceable author statement (Hultmark, 1995.10.11) traceable author statement (Rawson, 2003)
Sequence Ontology: Class of Gene
	gene (Cook, 2008.12.1) nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Protein-protein
Interacting group Assay References
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions HLH106 allele Gene References
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 65424 DroID - A comprehensive database of gene and protein interactions. • FBgn0261283 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 40155
Orthologs
Genome-wide drosophilid orthologs	Dana\SREBP Dere\SREBP Dgri\SREBP Dmoj\SREBP Dper\SREBP Dpse\SREBP Dsec\SREBP Dvir\SREBP Dwil\SREBP Dyak\SREBP
Curated drosophilid orthologs	Dpse\SREBP
Linkouts	InParanoid A subset of ortholog calls from InParanoid. • AAEL010555-PA Aedes aegypti (mosquito) AGAP000076-PA Anopheles gambiae (mosquito) XP_396866.3 Apis mellifera (honey bee) XP_001947552.1 Acyrthosiphon pisum (pea aphid) 117231 Branchiostoma floridae (lancelet) 210992 Branchiostoma floridae (lancelet) BGIBMGA001211-PA Bombyx mori (silk worm) ENSBTAP00000010372 Bos taurus (bovine) CBP32756 Caenorhabditis briggsae (nematode) CE19180 Caenorhabditis elegans (worm) ENSCAFP00000027222 Canis familiaris (dog) JA01682 Caenorhabditis japonica (nematode) CPIJ018167 Culex pipens (mosquito) ENSCPOP00000002221 Cavia porcellus (guinea pig) RP30602 Caenorhabditis remanei (nematode) ENSCSAVP00000017257 Ciona savignyi (sedentary tunicate) 165299 Capitella spl (polychaete worm) 201893 Daphnia pulex (daphnia) ENSDARP00000087122 Danio rerio (zebra fish) ENSECAP00000017936 Equus caballus (horse) ENSGACP00000015966 Gymnopilus aculeatus (mushroom) ENSGALP00000019416 Gallus gallus (chicken) 107185 Hypsipyla robusta (cedar shoot borer) ENSP00000348069 Homo sapiens (human) ISCW018168-PA Ixodes scapularis (deer tick) 224211 Lottia gigantea (owl limpet) 32649 Monocosta brevicollis (choanoflagellate) ENSMODP00000020735 Monodelphis domestica (gray opossum) ENSMMUP00000012722 Macaca mulatta (rhesus monkey) ENSMUSP00000020846 Mus musculus (house mouse) 95178 Nematostella vectensis (starlet anemone) XP_001608182.1 Nasonia vitripennis (wasp) ENSOANP00000019426 Ornithorynchus anatinus (platypus) ENSORLP00000011832 Oryzias latipes (japanese killifish) PHUM007023-PA Pediculus humanus (human body louse) PP07739 Pristionchus pacificus (nematode) ENSPPYP00000009038 Pongo pygmaeus (orangutan) ENSPTRP00000024869 Pan troglodytes (chimpanzee) ENSRNOP00000050057 Rattus norvegicus (norway rat) SPBC354.05c Schizosaccharomyces pombe (fission yeast) XP_795556.1 Strongylocentrotus purpuratus (purple sea urchin) 62233 Trichoplax adhaerens (metazoa) XP_974195.1 Tribolium castaneum (red flour beetle) ENSTNIP00000014917 Tetraodon nigroviridis (green spotted pufferfish) ENSTRUP00000020514 Takifugu rubripes (pufferfish Takifugu) ENSXETP00000037964 Xenopus tropicalis (frog) OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • PB12202 NV10553 LH19266 ISCW018168 FBgn0236960 FBgn0219495 FBgn0198580 FBgn0186499 FBgn0186498 FBgn0174544 JGI_V11_201893 FBgn0081122 FBgn0153336 FBgn0134398 FBgn0122129 FBgn0108291 FBgn0100584 CPIJ008607 CPIJ018167 BGIBMGA001211 ACYPI005432 GB30339 AGAP000076 AAEL010555 PHUM138160 GLEAN_07163
Stocks & Reagents
Stocks Listed in FlyBase ( 19 )
Bloomington	25975 y1 v1; P{TRiP.JF01997}attP2 8236 y1 w1118; P{UAS-HLH106.Exel}3 8237 P{UAS-HLH106.Exel}1, y1 w1118 8238 P{UAS-HLH106.Ndel}1, y1 w1118 8239 y1 w1118; P{UAS-HLH106.Ndel}2 8240 y1 w1118; P{UAS-HLH106.Ndel}3 8243 P{UAS-HLH106.Cdel}1, y1 w1118 8244 y1 w1118; P{UAS-HLH106.Cdel}2 8245 y1 w1118; P{UAS-HLH106.P450}3
Harvard	- P{XP}HLH106d08008
VDRC	v37640 w1118; P{GD4360}v37640 v37641 w1118; P{GD4360}v37641
	More stocks available...
Genomic Clones ( 1 )
	BACR01B21 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 48 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	LP12374
Other clones
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	GH06138 GH06327 GH10860 HL01847 LD04332 RE30381 RH13547 RH41520 RH61422 SD04874 SD05333 SD19117 SD19878 SD21767 SD21793 SD25044 SD27792
Other clones	76442 97070 97264 122909 475293 523096 CK01.7B.D7 CK01.21A.D11 CK01.51B.F4 CK01.62D.C7 CK01.66A.H1 EK053729 EK106301 EK206518 EK219324 EK245831 EN03418 ESG0111a.B21.1_B06 FGX001A06 RP004154736 RP004175280 RP004175969 RP004236829 RP004253067 RP004254036 RP004256675 RP004257965 RP004258615 RP004453779 RP004456197
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0261283 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 40155
Antibody Information
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of
Source for database merge of	Source for merge of: HLH106 l(3)76BDw (Kennison, 2009.7.23)
Additional comments
Other Comments
	S2 cells treated with dsRNA generated against this gene show reduced phagocytosis of Candida albicans compared to untreated cells. (Stroschein-Stevenson et al., 2006) RNAi generated by PCR using primers directed to this gene causes a cell growth and viability phenotype when assayed in Kc167 and S2R+ cells. (Boutros et al., 2004) Phosphatidylethanolamine controls the release of HLH106 protein from cell membranes. (Dobrosotskaya et al., 2002) Area matching Drosophila HLH106 gene, Acc. No. U38238. (Davies, 2001.3.15) HLH106, a SREBP homolog from Drosophila, has been isolated. The similarity in the domain structure to vertebrate SREBP is a strong argument that the proteins have related functions. (Theopold et al., 1996) HLH106 is related to human sterol regulatory protein SREBP-1. (Ekengren et al., 1995)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_079442 NM_168815 NM_168816 RefSeq (Proteins) • NP_524166 NP_730449 NP_730450 DDBJ / EMBL / GenBank • AAA97864 AAF49115 AAN11631 AAN11632 AAQ23603 AI297927 AX093934 BT010285 CZ468591 CZ476030 U38238 Entrez Gene - A searchable database of RefSeq genes. • 40155 UniProtKB/TrEMBL • Q9VW37 Q24146
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Helix-loop-helix DNA-binding (IPR011598)
Linkouts
	BioGRID - A database of protein and genetic interactions • 65424 DroID - A comprehensive database of gene and protein interactions. • FBgn0261283 DRSC - Results from RNAi screens. • FBgn0261283 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0261283 FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0261283 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 40155 InParanoid A subset of ortholog calls from InParanoid. • AAEL010555-PA Aedes aegypti (mosquito) AGAP000076-PA Anopheles gambiae (mosquito) XP_396866.3 Apis mellifera (honey bee) XP_001947552.1 Acyrthosiphon pisum (pea aphid) 117231 Branchiostoma floridae (lancelet) 210992 Branchiostoma floridae (lancelet) BGIBMGA001211-PA Bombyx mori (silk worm) ENSBTAP00000010372 Bos taurus (bovine) CBP32756 Caenorhabditis briggsae (nematode) CE19180 Caenorhabditis elegans (worm) ENSCAFP00000027222 Canis familiaris (dog) JA01682 Caenorhabditis japonica (nematode) CPIJ018167 Culex pipens (mosquito) ENSCPOP00000002221 Cavia porcellus (guinea pig) RP30602 Caenorhabditis remanei (nematode) ENSCSAVP00000017257 Ciona savignyi (sedentary tunicate) 165299 Capitella spl (polychaete worm) 201893 Daphnia pulex (daphnia) ENSDARP00000087122 Danio rerio (zebra fish) ENSECAP00000017936 Equus caballus (horse) ENSGACP00000015966 Gymnopilus aculeatus (mushroom) ENSGALP00000019416 Gallus gallus (chicken) 107185 Hypsipyla robusta (cedar shoot borer) ENSP00000348069 Homo sapiens (human) ISCW018168-PA Ixodes scapularis (deer tick) 224211 Lottia gigantea (owl limpet) 32649 Monocosta brevicollis (choanoflagellate) ENSMODP00000020735 Monodelphis domestica (gray opossum) ENSMMUP00000012722 Macaca mulatta (rhesus monkey) ENSMUSP00000020846 Mus musculus (house mouse) 95178 Nematostella vectensis (starlet anemone) XP_001608182.1 Nasonia vitripennis (wasp) ENSOANP00000019426 Ornithorynchus anatinus (platypus) ENSORLP00000011832 Oryzias latipes (japanese killifish) PHUM007023-PA Pediculus humanus (human body louse) PP07739 Pristionchus pacificus (nematode) ENSPPYP00000009038 Pongo pygmaeus (orangutan) ENSPTRP00000024869 Pan troglodytes (chimpanzee) ENSRNOP00000050057 Rattus norvegicus (norway rat) SPBC354.05c Schizosaccharomyces pombe (fission yeast) XP_795556.1 Strongylocentrotus purpuratus (purple sea urchin) 62233 Trichoplax adhaerens (metazoa) XP_974195.1 Tribolium castaneum (red flour beetle) ENSTNIP00000014917 Tetraodon nigroviridis (green spotted pufferfish) ENSTRUP00000020514 Takifugu rubripes (pufferfish Takifugu) ENSXETP00000037964 Xenopus tropicalis (frog) InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 40155 modMine - Data generated by the modENCODE project. • FBgn0261283 OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • PB12202 NV10553 LH19266 ISCW018168 FBgn0236960 FBgn0219495 FBgn0198580 FBgn0186499 FBgn0186498 FBgn0174544 JGI_V11_201893 FBgn0081122 FBgn0153336 FBgn0134398 FBgn0122129 FBgn0108291 FBgn0100584 CPIJ008607 CPIJ018167 BGIBMGA001211 ACYPI005432 GB30339 AGAP000076 AAEL010555 PHUM138160 GLEAN_07163
Synonyms & Secondary IDs ( 17 )
Reported As
Symbol Synonym	CG8522 (Seegmiller et al., 2002, Ramet et al., 2002, Molnar et al., 2006, Perkins et al., 1.15.2009, Ni et al., 2011.7.19) dSREBP (Lim et al., 2011, Matthews et al., 2005, Kunte et al., 2005, Rawson, 2003, Dobrosotskaya et al., 2003, Seegmiller et al., 2002, Dobrosotskaya et al., 2002, Seegmiller et al., 2002, Rawson et al., 2003, Kunte et al., 2006, Dong et al., 2007, Matthews et al., 2009, Amarneh et al., 2009, Kunte et al., 2006, Lee et al., 2010, Porstmann et al., 2008) dSrebp (Montooth et al., 2006) dsrebp (Matthews et al., 2010) HLH106 (White et al., 2011, Stroschein-Stevenson et al., 2006, Guo et al., 2008, Orme and Leevers, 2005, Kunte et al., 2006, Zhou et al., 2008, Cooper et al., 2010, Pospisilik et al., 2010, Suh et al., 2006, Porstmann et al., 2008, D'Ambrosio and Vale, 2010) HlH106 (Molnar et al., 2006) l(3)76BDw (Cook, 2008.12.1, Cooper et al., 2010) SREBP (Bauer et al., 2009, Higaki et al., 2004, Kunte et al., 2004, Nohturfft and Losick, 2002, Matthews et al., 2006, Matthews and Rawson, 2007, Callejo et al., 2007, Dorner et al., 2006, Guo et al., 2008, Suh et al., 2006, D'Ambrosio and Vale, 2010) Srebp   srebp (Belgacem and Martin, 2007)
Name Synonym	Drosophila sterol regulatory element binding protein (Montooth et al., 2006) Helix loop helix protein 106 (Ekengren et al., 1995, ) lethal (3) 76BDw   Sterol regulatory element-binding protein (Dobrosotskaya et al., 2002) Sterol Regulatory Element Binding Protein (Matthews et al., 2010) sterol regulatory element-binding protein (D'Ambrosio and Vale, 2010) sterol-responsive element-binding protein (Bauer et al., 2009)
Secondary FlyBase IDs
	FBgn0015234 FBgn0063456 FBgn0260652
References ( 67 )
Generate a list of	All references relating to this gene ( 67 )
List References by type	Research paper  ( 31 ) Supplementary material  ( 4 ) Review  ( 5 ) Personal communication to FlyBase  ( 7 ) Abstract  ( 10 ) FlyBase analysis  ( 2 ) Patent  ( 1 ) DNA/RNA sequence record  ( 2 ) Computer file  ( 3 ) Automatic genome annotation  ( 1 )
Recent research papers ( 7 )
	Lim et al., 2011, Genes Dev. 25(2): 189--200 Phospholipid homeostasis regulates lipid metabolism and cardiac function through SREBP signaling in Drosophila. [FBrf0212844] White et al., 2011, J. Cell Biol. 193(4): 677--694 Drosophila histone locus bodies form by hierarchical recruitment of components. [FBrf0213662] Cooper et al., 2010, Genetics 185(3): 811--822 Molecular Genetic Analysis of Chd3 and Polytene Chromosome Region 76B-D in Drosophila melanogaster. [FBrf0211329] D'Ambrosio and Vale, 2010, J. Cell Biol. 191(3): 471--478 A whole genome RNAi screen of Drosophila S2 cell spreading performed using automated computational image analysis. [FBrf0212211] Lee et al., 2010, Science 327(5970): 1223--1228 Sestrin as a feedback inhibitor of TOR that prevents age-related pathologies. [FBrf0210161] Matthews et al., 2010, Genetics 185(1): 189--198 Activation of Sterol Regulatory Element Binding Proteins in the Absence of Scap in Drosophila melanogaster. [FBrf0210903] Pospisilik et al., 2010, Cell 140(1): 148--160 Drosophila genome-wide obesity screen reveals hedgehog as a determinant of brown versus white adipose cell fate. [FBrf0212676] Show all research papers ...
Recent reviews (0)
	All reviews listed in FlyBase were published before 2010 Show reviews ...