FB2020_06, released Dec 22, 2020

Gene: Dmel\SREBP

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General Information
Symbol
Dmel\SREBP
Species
D. melanogaster
Name
Sterol regulatory element binding protein
Annotation Symbol
CG8522
Feature Type
protein_coding_gene
FlyBase ID
FBgn0261283
Gene Model Status
Current
Stock Availability
32 publicly available
Gene Snapshot
Sterol regulatory element binding protein (SREBP) encodes a membrane protein that functions as a master-regulator of lipogenesis. It activates transcription of lipogenic genes upon reduction of lipid or cholesterol levels. [Date last reviewed: 2019-02-28]
Other Summaries
Also Known As

dSREBP, HLH106, l(3)76BDw, SREBF1, Helix loop helix protein 106

Key Links
Genomic Location
Cytogenetic map
Sequence location
3L:19,793,935..19,798,979 [+]
Recombination map

3-46

RefSeq locus
NT_037436 REGION:19793935..19798979
Sequence
Get Decorated FASTA
Genomic Maps
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
NCBI
UCSC
Ensembl
PopFly
Function
GO Summary Ribbons
Gene Ontology (GO) Annotations (16 terms)
Molecular Function (4 terms)
Terms Based on Experimental Evidence (1 term)
CV Term
Evidence
References
enables DNA-binding transcription activator activity, RNA polymerase II-specific
inferred from direct assay
(Rosenfeld and Osborne, 1998)
Terms Based on Predictions or Assertions (3 terms)
CV Term
Evidence
References
enables DNA-binding transcription factor activity, RNA polymerase II-specific
inferred from biological aspect of ancestor with PANTHER:PTN002488844
(assigned by GO_Central )
(Gaudet et al., 2011)
enables protein dimerization activity
inferred from electronic annotation with InterPro:IPR011598
(assigned by InterPro )
(FlyBase Curators et al., 2004-)
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding
inferred from biological aspect of ancestor with PANTHER:PTN002488844
(assigned by GO_Central )
(Gaudet et al., 2011)
Biological Process (8 terms)
Terms Based on Experimental Evidence (4 terms)
CV Term
Evidence
References
involved_in cell morphogenesis
inferred from mutant phenotype
(D'Ambrosio and Vale, 2010)
involved_in fatty acid homeostasis
inferred from mutant phenotype
(Kunte et al., 2006)
involved_in regulation of autophagy of mitochondrion
inferred from mutant phenotype
(Ivatt et al., 2014)
involved_in SREBP signaling pathway
inferred from direct assay
(Rosenfeld and Osborne, 1998)
Terms Based on Predictions or Assertions (4 terms)
CV Term
Evidence
References
involved_in fatty acid biosynthetic process
non-traceable author statement
(Nohturfft and Losick, 2002)
involved_in positive regulation of transcription, DNA-templated
traceable author statement
(Rawson, 2003)
involved_in regulation of fatty acid biosynthetic process
traceable author statement
(Rawson, 2003)
involved_in regulation of transcription by RNA polymerase II
inferred from biological aspect of ancestor with PANTHER:PTN002488844
(assigned by GO_Central )
(Gaudet et al., 2011)
Cellular Component (4 terms)
Terms Based on Experimental Evidence (4 terms)
CV Term
Evidence
References
located_in endoplasmic reticulum membrane
inferred from direct assay
(Rosenfeld and Osborne, 1998)
located_in membrane
inferred from direct assay
(Theopold et al., 1996)
located_in nuclear membrane
inferred from direct assay
(Rosenfeld and Osborne, 1998)
located_in nucleus
inferred from direct assay
(Rosenfeld and Osborne, 1998)
Terms Based on Predictions or Assertions (1 term)
CV Term
Evidence
References
located_in nucleus
traceable author statement
(Rawson, 2003)
inferred from biological aspect of ancestor with PANTHER:PTN002488844
(assigned by GO_Central )
(Gaudet et al., 2011)
Gene Group (FlyBase)
Protein Family (UniProt)
-
Protein Signatures (InterPro)
Summaries
Gene Group (FlyBase)
BASIC HELIX-LOOP-HELIX TRANSCRIPTION FACTORS -
Basic helix-loop-helix (bHLH) transcription factors are sequence-specific DNA-binding proteins that regulate transcription. They are characterized by a 60 amino acid region comprising a basic DNA binding domain followed by a HLH motif formed from two amphipathic α-helices connected by a loop. bHLH transcription factors form homo- and hetero-dimeric complexes, which bind to a E box consensus sequence. (Adapted from PMID:15186484).
Summary (Interactive Fly)

bHLH-leucine zipper transcription factor - membrane bound HLH106 is released by phosphatidylethanolamine, exerting feedback control on the synthesis of fatty acids and phospholipids - cleavage by Drice releases an SREBP fragment to travel to the nucleus where it mediates the increased transcription of target genes needed for lipid synthesis and uptake

Gene Model and Products
Number of Transcripts
4
Number of Unique Polypeptides
1

Please see the JBrowse view of Dmel\SREBP for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Comments on Gene Model

Low-frequency RNA-Seq exon junction(s) not annotated.

Annotated transcripts do not represent all supported alternative splices within 5' UTR.

Gene model reviewed during 5.46

Sequence Ontology: Class of Gene
gene
(Cook, 2008.12.1)
nuclear_gene
protein_coding_gene
Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
SREBP-RA
FBtr0074873
NM_168815
3841
1113
SREBP-RB
FBtr0074874
NM_168816
3951
1113
SREBP-RC
FBtr0074875
NM_079442
3818
1113
SREBP-RD
FBtr0333877
NM_001275135
3920
1113
Additional Transcript Data and Comments
Reported size (kB)

3.8 (northern blot)

(Theopold et al., 1996)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
RefSeq ID
GenBank
SREBP-PA
FBpp0074642
124.5
1113
7.75
NP_730449
AAF49115
SREBP-PB
FBpp0074643
124.5
1113
7.75
NP_730450
AAN11631
SREBP-PC
FBpp0074644
124.5
1113
7.75
NP_524166
AAN11632
SREBP-PD
FBpp0306009
124.5
1113
7.75
NP_001262064
AGB94757
Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

1113 aa isoforms: SREBP-PA, SREBP-PB, SREBP-PC, SREBP-PD
Additional Polypeptide Data and Comments
Reported size (kDa)

1113 (aa); 130, 85 (kD observed); 125 (kD predicted)

(Theopold et al., 1996)
Comments
External Data
Crossreferences
InterPro - A database of protein families, domains and functional sites
Linkouts
Sequences Consistent with the Gene Model
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\SREBP using the Feature Mapper tool.

External Data
Crossreferences
Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
Linkouts
Expression Data
Expression Summary Ribbons
Colored tiles in ribbon indicate that expression data has been curated by FlyBase for that anatomical location. Colorless tiles indicate that there is no curated data for that location.
For complete stage-specific expression data, view the modENCODE Development RNA-Seq section under High-Throughput Expression below.
Transcript Expression
Polypeptide Expression
mass spectroscopy
Stage
Tissue/Position (including subcellular localization)
Reference
adult stage
adult head
(Aradska et al., 2015)
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Evidence
References
located_in endoplasmic reticulum membrane
inferred from direct assay
(Rosenfeld and Osborne, 1998)
located_in membrane
inferred from direct assay
(Theopold et al., 1996)
located_in nuclear membrane
inferred from direct assay
(Rosenfeld and Osborne, 1998)
located_in nucleus
inferred from direct assay
(Rosenfeld and Osborne, 1998)
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\SREBP in GBrowse 2
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Bulk Downloads
RNA-Seq RPKM values for all genes
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
FLIGHT - Cell culture data for RNAi and other high-throughput technologies
Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
Flygut - An atlas of the Drosophila adult midgut
Images
FlyBase Wiki
Image Based Resources
Alleles, Insertions, and Transgenic Constructs
Phenotypes
For more details about a specific phenotype click on the relevant allele symbol.
Lethality
Allele
lethal
lethal (with Df(3L)kto2)
lethal (with SREBP52)
lethal (with SREBP189)
lethal | heat sensitive, with Scer\GAL4Bx-MS1096
lethal | larval stage, with Scer\GAL4da.G32
lethal | pupal stage, with Scer\GAL4da.G32
lethal | recessive
lethal - all die before end of second instar larval stage | recessive
partially lethal - majority live | conditional
viable, with Dcr-2UAS.cDa, Scer\GAL4elav.PLu
viable, with Scer\GAL4Mef2.PR
viable, with Scer\GAL4pnr-MD237
viable, with Scer\GAL4tin.CΔ4
viable | conditional
Other Phenotypes
Allele
decreased cell size, with Scer\GAL4en-e16E
developmental rate defective, with Scer\GAL4da.G32
neuroanatomy defective | adult stage, with Scer\GAL4ninaE.PT
size defective | adult stage, with Scer\GAL4ninaE.PT
size defective | adult stage, with Scer\GAL4NP0001
small body, with Scer\GAL4da.G32
small body | recessive | second instar larval stage
some die during second instar larval stage | recessive
visible, with Scer\GAL4Bx-MS1096
visible, with Scer\GAL4en-e16E
Phenotype manifest in
Allele
adult heart, with Scer\GAL4HCH.Hand
adult heart ventral longitudinal muscle, with Scer\GAL4HCH.Hand
adult midgut, with Scer\GAL4NP0001
adult optic lobe glial cell | cell non-autonomous, with Scer\GAL4nSyb.PS
axon | adult stage, with Scer\GAL4ninaE.PT
capitate projection | adult stage, with Scer\GAL4ninaE.PT
dense core granule | adult stage, with Scer\GAL4ninaE.PT
eye photoreceptor cell | adult stage, with Scer\GAL4ninaE.PT
lipid droplet | adult stage, with Scer\GAL4NP0001
lipid droplet | adult stage | cell non-autonomous, with Scer\GAL4nSyb.PS
neuronal cell body | adult stage, with Scer\GAL4ninaE.PT
optic cartridge | adult stage, with Scer\GAL4ninaE.PT
synaptic vesicle | adult stage, with Scer\GAL4ninaE.PT
T-bar | adult stage, with Scer\GAL4ninaE.PT
wing, with Scer\GAL4Bx-MS1096
wing, with Scer\GAL4da.G32
wing blade posterior compartment, with Scer\GAL4en-e16E
Orthologs
Downloads
Download All DIOPT Orthologs
Download All OrthoDB Orthologs
Human Orthologs (via DIOPT v8.0)
Homo sapiens (Human) (7)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
eggNOG
Hieranoid
Homologene
Inparanoid
Isobase
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
RoundUp
TreeFam
ZFIN
Alignment
Complementation?
Transgene?
Hsap\SREBF2
13 of 15
Yes
Yes
Hsap\SREBF1
12 of 15
No
Yes
Hsap\MITF
1 of 15
No
No
1  
Hsap\MYCN
1 of 15
No
No
Hsap\TFEB
1 of 15
No
No
1  
Hsap\USF1
1 of 15
No
No
Hsap\USF2
1 of 15
No
No
Model Organism Orthologs (via DIOPT v8.0)
Mus musculus (laboratory mouse) (8)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
eggNOG
Hieranoid
Homologene
Inparanoid
Isobase
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
RoundUp
TreeFam
ZFIN
Alignment
Complementation?
Transgene?
Mmus\Srebf2
13 of 15
Yes
Yes
Mmus\Srebf1
12 of 15
No
Yes
Mmus\Mitf
1 of 15
No
No
Mmus\Mycn
1 of 15
No
No
Mmus\Mycs
1 of 15
No
No
Mmus\Tfe3
1 of 15
No
No
Mmus\Tfeb
1 of 15
No
No
Mmus\Usf1
1 of 15
No
No
Rattus norvegicus (Norway rat) (3)
Rnor\Srebf1
12 of 13
Yes
Yes
Rnor\Srebf2
11 of 13
No
Yes
Rnor\Mycs
1 of 13
No
Yes
Xenopus tropicalis (Western clawed frog) (3)
Xtro\srebf2
8 of 12
Yes
Yes
Xtro\srebf1
7 of 12
No
Yes
Xtro\mycn
1 of 12
No
Yes
Danio rerio (Zebrafish) (8)
Drer\srebf2
12 of 15
Yes
Yes
Drer\srebf1
8 of 15
No
Yes
Drer\mitfa
1 of 15
No
No
Drer\mitfb
1 of 15
No
No
Drer\tfeb
1 of 15
No
No
Drer\usf1
1 of 15
No
No
Drer\usf1l
1 of 15
No
No
Drer\usf2
1 of 15
No
No
Caenorhabditis elegans (Nematode, roundworm) (2)
Cele\sbp-1
14 of 15
Yes
Yes
Cele\hlh-30
1 of 15
No
No
Arabidopsis thaliana (thale-cress) (0)
No records found.
Saccharomyces cerevisiae (Brewer's yeast) (3)
Scer\HMS1
3 of 15
Yes
Yes
Scer\RTG3
1 of 15
No
No
Scer\TYE7
1 of 15
No
Yes
Schizosaccharomyces pombe (Fission yeast) (3)
Spom\sre2
3 of 12
Yes
Yes
Spom\sre1
2 of 12
No
Yes
Spom\SPAC3F10.12c
1 of 12
No
No
Ortholog(s) in Drosophila Species (via OrthoDB v9.1) ( EOG091902DZ )
Organism
Common Name
Gene
AAA Syntenic Ortholog
Multiple Dmel Genes in this Orthologous Group
Drosophila suzukii
Spotted wing Drosophila
Dsuz\DS10_00007206
Drosophila simulans
Dsim\GD14826
Drosophila sechellia
Dsec\SREBP
Drosophila erecta
Dere\SREBP
Drosophila yakuba
Dyak\SREBP
Drosophila ananassae
Dana\SREBP
Drosophila pseudoobscura pseudoobscura
Dpse\SREBP
Drosophila persimilis
Dper\SREBP
Drosophila willistoni
Dwil\SREBP
Drosophila virilis
Dvir\SREBP
Drosophila mojavensis
Dmoj\SREBP
Drosophila grimshawi
Dgri\SREBP
Orthologs in non-Drosophila Dipterans (via OrthoDB v9.1) ( EOG0915019Y )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Musca domestica
House fly
Mdoa\17018040
Glossina morsitans
Tsetse fly
Gmor\GMOY011239
Lucilia cuprina
Australian sheep blowfly
Lcup\FF38_12282
Lucilia cuprina
Australian sheep blowfly
Lcup\FF38_10910
Mayetiola destructor
Hessian fly
Mdes\Mdes002836
Aedes aegypti
Yellow fever mosquito
Aaeg\AAEL010555
Anopheles darlingi
American malaria mosquito
Adar\ADAC008255
Anopheles gambiae
Malaria mosquito
Agam\AGAP000076
Culex quinquefasciatus
Southern house mosquito
Cqui\CPIJ018167
Culex quinquefasciatus
Southern house mosquito
Cqui\CPIJ008607
Orthologs in non-Dipteran Insects (via OrthoDB v9.1) ( EOG090W01MU )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Bombyx mori
Silkmoth
Bmor\BGIBMGA001211
Danaus plexippus
Monarch butterfly
Dple\DPOGS215981-PA
Heliconius melpomene
Postman butterfly
Hmel\HMEL010100
Heliconius melpomene
Postman butterfly
Hmel\HMEL008680
Apis florea
Little honeybee
Aflo\3339744692
Apis mellifera
Western honey bee
Amel\GB54953
Bombus impatiens
Common eastern bumble bee
Bimp\BIMP13501
Bombus terrestris
Buff-tailed bumblebee
Bter\15204508
Linepithema humile
Argentine ant
Lhum\LH19266
Megachile rotundata
Alfalfa leafcutting bee
Mrot\MROTU:0015a3
Nasonia vitripennis
Parasitic wasp
Nvit\Nasvi2EG001141
Dendroctonus ponderosae
Mountain pine beetle
Dpod\YQE_07365
Tribolium castaneum
Red flour beetle
Tcas\GLEAN_07163
Pediculus humanus
Human body louse
Phum\PHUM138160
Rhodnius prolixus
Kissing bug
Rpro\RPRC014734
Cimex lectularius
Bed bug
Clec\CLEC007933
Acyrthosiphon pisum
Pea aphid
Apim\ACYPI005432
Zootermopsis nevadensis
Nevada dampwood termite
Znev\Znev_13490
Orthologs in non-Insect Arthropods (via OrthoDB v9.1) ( EOG090X01KT )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strigamia maritima
European centipede
Smar\SMAR011485
Ixodes scapularis
Black-legged tick
Isca\ISCW018168
Stegodyphus mimosarum
African social velvet spider
Smim\KFM83551.1
Stegodyphus mimosarum
African social velvet spider
Smim\KFM74187.1
Stegodyphus mimosarum
African social velvet spider
Smim\KFM57920.1
Tetranychus urticae
Two-spotted spider mite
Turt\tetur08g03870
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_201893
Orthologs in non-Arthropod Metazoa (via OrthoDB v9.1) ( EOG091G01RE )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Srebp
Ciona intestinalis
Vase tunicate
Cint\srebp
Gallus gallus
Domestic chicken
Ggal\SREBF2
Gallus gallus
Domestic chicken
Ggal\ENSGALG00000027188
Paralogs
Downloads
Download All DIOPT Paralogs
Paralogs (via DIOPT v8.0)
Drosophila melanogaster (Fruit fly) (2)
Gene Symbol
Score
Source
Compara
eggNOG
Homologene
Inparanoid
Isobase
OrthoDB
OrthoFinder
orthoMCL
Panther
RoundUp
Alignment
Mitf
1 of 10
Usf
1 of 10
Human Disease Associations
FlyBase Human Disease Model Reports
Disease Model Summary Ribbon
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 2 )
Potential Models Based on Orthology ( 0 )
Human Ortholog
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 2 )
Allele
Disease
Interaction
References
SREBP52
ameliorates  heart conduction disease
modeled by eas2
(Lim et al., 2011)
SREBP189
ameliorates  heart conduction disease
modeled by eas2
(Lim et al., 2011)
Disease Associations of Human Orthologs (via DIOPT v8.0 and OMIM)
Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
Homo sapiens (Human)
Gene name
Score
OMIM
OMIM Phenotype
DO term
Complementation?
Transgene?
SREBF2; sterol regulatory element binding transcription factor 2
13 of 15
600481
      SREBF1; sterol regulatory element binding transcription factor 1
      12 of 15
      184756
        Functional Complementation Data
        Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
        Interactions
        Summary of Physical Interactions
        esyN Network Diagram
        Show neighbor-neighbor interactions:
        Select Layout:
        Legend:
        Protein
        RNA
        Selected Interactor(s)
        Interactions Browser
        View in Interactions Browser
        Please see the Physical Interaction reports below for full details
        protein-protein
        Physical Interaction
        Assay
        References
        SREBP - lms
        two hybrid array
        (Shokri et al., 2019)
        Summary of Genetic Interactions
        esyN Network Diagram
        esyN Network Key:
        Suppression
        Enhancement
        View in Interactions Browser
        Please look at the allele data for full details of the genetic interactions
        Starting gene(s)
        Interaction type
        Interacting gene(s)
        Reference
        SREBP
        suppressible
        Ldh
        (Liu et al., 2017)
        SREBP
        suppressible
        out
        (Liu et al., 2017)
        SREBP
        suppressible
        Pdha
        (Liu et al., 2017)
        SREBP
        suppressible
        Sln
        (Liu et al., 2017)
        Starting gene(s)
        Interaction type
        Interacting gene(s)
        Reference
        eas
        suppressible
        SREBP
        (Lim et al., 2011)
        S2P
        enhanceable
        SREBP
        (Amarneh et al., 2009)
        External Data
        Linkouts
        BioGRID - A database of protein and genetic interactions.
        DroID - A comprehensive database of gene and protein interactions.
        InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.
        MIST (protein-protein) - An integrated Molecular Interaction Database
        Pathways
        Signaling Pathways (FlyBase)
        Metabolic Pathways
        External Data
        Linkouts
        Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
        Genomic Location and Detailed Mapping Data
        Chromosome (arm)
        3L
        Recombination map

        3-46

        Cytogenetic map
        76C5-76C6
        Sequence location
        3L:19,793,935..19,798,979 [+]
        FlyBase Computed Cytological Location
        Cytogenetic map
        Evidence for location
        76C5-76C6
        Experimentally Determined Cytological Location
        Cytogenetic map
        Notes
        References
        Experimentally Determined Recombination Data
        Location

        3-46

        (FlyBase, 2016)

        3-43.1

        (Comeron et al., 2012)

        3-

        (Horn et al., 2003)
        Left of (cM)
        Right of (cM)
        Notes
        Stocks and Reagents
        Stocks (32)
        Genomic Clones (13)
         

        Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

        cDNA Clones (36)
         

        Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

        cDNA clones, fully sequenced
        BDGP DGC clones
        Other clones
          Drosophila Genomics Resource Center cDNA clones

          For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

          cDNA Clones, End Sequenced (ESTs)
          BDGP DGC clones
          Other clones
          RNAi and Array Information
          Linkouts
          DRSC - Results frm RNAi screens
          GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
          Antibody Information
          Laboratory Generated Antibodies
           

          polyclonal

          (Xie et al., 2015)
          Commercially Available Antibodies
           
          Other Information
          Relationship to Other Genes
          Source for database identify of

          Source for identity of: SREBP HLH106

          (FlyBase, 2009-)
          Source for database merge of

          Source for merge of: HLH106 l(3)76BDw

          (Kennison, 2009.7.23)
          Additional comments

          Renamed from 'HLH106' to 'SREBP' to be more informative and reflect clear preference in the literature.

          (FlyBase, 2009-)
          Other Comments

          SREBP mutants exhibit lipid droplet accumulation in glia, but this does not lead to premature neurodegeneration.

          (Liu et al., 2015)

          S2 cells treated with dsRNA generated against this gene show reduced phagocytosis of Candida albicans compared to untreated cells.

          (Stroschein-Stevenson et al., 2006)

          RNAi generated by PCR using primers directed to this gene causes a cell growth and viability phenotype when assayed in Kc167 and S2R+ cells.

          (Boutros et al., 2004)

          Phosphatidylethanolamine controls the release of HLH106 protein from cell membranes.

          (Dobrosotskaya et al., 2002)

          Area matching Drosophila HLH106 gene, Acc. No. U38238.

          (Davies, 2001.3.15)

          HLH106, a SREBP homolog from Drosophila, has been isolated. The similarity in the domain structure to vertebrate SREBP is a strong argument that the proteins have related functions.

          (Theopold et al., 1996)

          HLH106 is related to human sterol regulatory protein SREBP-1.

          (Ekengren et al., 1995)
          Origin and Etymology
          Discoverer
          Etymology
          Identification
          External Crossreferences and Linkouts ( 43 )
          Sequence Crossreferences
          NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
          GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
          GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
          RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
          UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information
          Other crossreferences
          BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
          Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones
          Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
          Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
          Flygut - An atlas of the Drosophila adult midgut
          FlyMine - An integrated database for Drosophila genomics
          GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
          iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)
          InterPro - A database of protein families, domains and functional sites
          KEGG Genes - Molecular building blocks of life in the genomic space.
          modMine - A data warehouse for the modENCODE project
          Linkouts
          BioGRID - A database of protein and genetic interactions.
          DroID - A comprehensive database of gene and protein interactions.
          DRSC - Results frm RNAi screens
          FLIGHT - Cell culture data for RNAi and other high-throughput technologies
          Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution
          InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.
          MIST (protein-protein) - An integrated Molecular Interaction Database
          Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
          Synonyms and Secondary IDs (22)
          Reported As
          Symbol Synonym
          CG8522
          (Chiang et al., 2016, Hosono et al., 2015, Kim et al., 2015, Schertel et al., 2013, Ni et al., 2011.7.19, Perkins et al., 2009.1.15, Molnar et al., 2006, Ramet et al., 2002, Seegmiller et al., 2002)
          HLH106
          (Brewer-Jensen et al., 2016, Chen et al., 2014, Gonzalez et al., 2014, Bonke et al., 2013, Lee et al., 2013, Lindsley et al., 2013, Schertel et al., 2013, Rawson, 2012.9.3, Grimberg et al., 2011, White et al., 2011, Cooper et al., 2010, D'Ambrosio and Vale, 2010, Pospisilik et al., 2010, Guo et al., 2008, Porstmann et al., 2008, Zhou et al., 2008, Kunte et al., 2006, Stroschein-Stevenson et al., 2006, Suh et al., 2006)
          HlH106
          (Molnar et al., 2006)
          SREBF1
          (Wangler et al., 2017, Ivatt and Whitworth, 2014, Ivatt et al., 2014)
          SREBP
          (Luo et al., 2020, Toprak et al., 2020, Zipper et al., 2020, Chen et al., 2019, Mirth et al., 2019, Sênos Demarco et al., 2019, Shokri et al., 2019, Su et al., 2019, Swevers, 2019, Tsai et al., 2019, Westfall et al., 2019, Lee et al., 2018, Lehmann, 2018, Park et al., 2018, Swevers et al., 2018, Westfall et al., 2018, Yin et al., 2018, Chng et al., 2017, Liu and Jin, 2017, Sieber and Spradling, 2017, Transgenic RNAi Project members, 2017-, Yan et al., 2017, Chiang et al., 2016, Diop and Bodmer, 2015, Diop et al., 2015, Liu et al., 2015, model organism Encyclopedia of Regulatory Network (modERN) Project, 2015-, Sanchez-Alvarez et al., 2015, Schertel et al., 2015, Sieber and Spradling, 2015, Xie et al., 2015, Song et al., 2014, Bonke et al., 2013, Rawson, 2013, Niwa and Niwa, 2011, D'Ambrosio and Vale, 2010, Bauer et al., 2009, Guo et al., 2008, Callejo et al., 2007, Matthews and Rawson, 2007, Cherry et al., 2006, Dorner et al., 2006, Matthews et al., 2006, Suh et al., 2006, Higaki et al., 2004, Kunte et al., 2004, Nohturfft and Losick, 2002)
          Srebp
          dSREBP
          (Bertolio et al., 2019, Álvarez-Rendón et al., 2018, Brookheart and Duncan, 2016, Zhao et al., 2012, Lim et al., 2011, Kühnlein, 2010, Lee et al., 2010, Amarneh et al., 2009, Matthews et al., 2009, Porstmann et al., 2008, Dong et al., 2007, Kunte et al., 2006, Kunte et al., 2006, Kunte et al., 2005, Matthews et al., 2005, Dobrosotskaya et al., 2003, Rawson, 2003, Rawson et al., 2003, Dobrosotskaya et al., 2002, Seegmiller et al., 2002, Seegmiller et al., 2002)
          dSrebp
          (Montooth et al., 2006)
          dsrebp
          (Ozdemir and Rawson, 2011, Matthews et al., 2010)
          l(3)76BDw
          (Cooper et al., 2010, Cook, 2008.12.1)
          srebp
          (Yu et al., 2020, Sundararajan and Miller, 2018, Meltzer et al., 2017, Wei et al., 2017, Belgacem and Martin, 2007)
          Name Synonyms
          Drosophila sterol regulatory element binding protein
          (Montooth et al., 2006)
          Helix loop helix protein 106
          (Ekengren et al., 1995)
          Sterol Regulatory Element Binding Protein
          (Matthews et al., 2010)
          Sterol regulatory element binding protein
          (Liu et al., 2015)
          Sterol regulatory element-binding protein
          (Dobrosotskaya et al., 2002)
          lethal (3) 76BDw
          sterol regulatory element binding protein
          (Diop and Bodmer, 2015)
          sterol regulatory element-binding protein
          (D'Ambrosio and Vale, 2010)
          sterol response element binding protein
          (Sundararajan and Miller, 2018)
          sterol-responsive element-binding protein
          (Bauer et al., 2009)
          transcription factor Sterol regulatory element binding protein
          (Bonke et al., 2013)
          Secondary FlyBase IDs
          • FBgn0015234
          • FBgn0063456
          • FBgn0260652
          Datasets (0)
          Study focus (0)
          Experimental Role
          Project
          Project Type
          Title
          References (152)