FB2025_02 , released April 17, 2025
Gene: Dmel\SREBP
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General Information
Symbol
Dmel\SREBP
Species
D. melanogaster
Name
Sterol regulatory element binding protein
Annotation Symbol
CG8522
Feature Type
protein_coding_gene
FlyBase ID
FBgn0261283
Gene Model Status
Current
Stock Availability
35 publicly available
Gene Summary
Sterol regulatory element binding protein (SREBP) encodes a membrane protein that functions as a master-regulator of lipogenesis. It activates transcription of lipogenic genes upon reduction of lipid or cholesterol levels. [Date last reviewed: 2019-02-28] (FlyBase Gene Snapshot)
All Summaries
Also Known As

HLH106, dSREBP, SREBF1, l(3)76BDw, SREBP1

Key Links
Genomic Location
Cytogenetic map
76C5-76C6
Sequence location
Recombination map
3-46
RefSeq locus
NT_037436 REGION:19793935..19798979
Sequence
Get Decorated FASTA
Genomic Maps
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
NCBI
UCSC
Ensembl
PopFly
Function
Gene Ontology (GO) Annotations (12 terms)
Molecular Function (4 terms)
Terms Based on Experimental Evidence (1 term)
CV Term
Evidence
References
enables DNA-binding transcription activator activity, RNA polymerase II-specific
inferred from direct assay
(Rosenfeld and Osborne, 1998)
Terms Based on Predictions or Assertions (3 terms)
CV Term
Evidence
References
enables DNA-binding transcription factor activity, RNA polymerase II-specific
inferred from biological aspect of ancestor with PANTHER:PTN002488844
(GO Reference Genome Project, 2011-)
enables protein dimerization activity
inferred from electronic annotation with InterPro:IPR011598, InterPro:IPR036638
(InterPro Project Members, 2004-)
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding
inferred from biological aspect of ancestor with PANTHER:PTN002488844
(GO Reference Genome Project, 2011-)
Biological Process (4 terms)
Terms Based on Experimental Evidence (3 terms)
CV Term
Evidence
References
involved_in fatty acid homeostasis
inferred from mutant phenotype
(Kunte et al., 2006)
involved_in lipid droplet formation
inferred from genetic interaction with FLYBASE:mir-210; FB:FBgn0262433
(Lyu et al., 2021)
involved_in SREBP signaling pathway
inferred from direct assay
(Rosenfeld and Osborne, 1998)
Terms Based on Predictions or Assertions (1 term)
CV Term
Evidence
References
involved_in regulation of transcription by RNA polymerase II
inferred from biological aspect of ancestor with PANTHER:PTN002488844
(GO Reference Genome Project, 2011-)
Cellular Component (4 terms)
Terms Based on Experimental Evidence (4 terms)
CV Term
Evidence
References
located_in endoplasmic reticulum membrane
inferred from direct assay
(Rosenfeld and Osborne, 1998)
located_in membrane
inferred from direct assay
(Theopold et al., 1996)
located_in nuclear membrane
inferred from direct assay
(Rosenfeld and Osborne, 1998)
located_in nucleus
inferred from direct assay
(Rosenfeld and Osborne, 1998)
Terms Based on Predictions or Assertions (1 term)
CV Term
Evidence
References
is_active_in nucleus
inferred from biological aspect of ancestor with PANTHER:PTN002488844
(GO Reference Genome Project, 2011-)
Gene Group (FlyBase)
Protein Family (UniProt)
-
Protein Signatures (InterPro)
Summaries
Gene Snapshot
Sterol regulatory element binding protein (SREBP) encodes a membrane protein that functions as a master-regulator of lipogenesis. It activates transcription of lipogenic genes upon reduction of lipid or cholesterol levels. [Date last reviewed: 2019-02-28]
Gene Group (FlyBase)
BASIC HELIX-LOOP-HELIX TRANSCRIPTION FACTORS -
Basic helix-loop-helix (bHLH) transcription factors are sequence-specific DNA-binding proteins that regulate transcription. They are characterized by a 60 amino acid region comprising a basic DNA binding domain followed by a HLH motif formed from two amphipathic α-helices connected by a loop. bHLH transcription factors form homo- and hetero-dimeric complexes, which bind to a E box consensus sequence. (Adapted from PMID:15186484).
SREBP-SCAP COMPLEX -
The SREBP-SCAP complex is formed by the binding of sterol regulatory element binding protein (SREBP) by the SREBP-cleavage-activating protein (SCAP) in the ER membrane. SCAP escorts SREBP from the ER to the Golgi complex, where SREBP is cleaved to yield a transcription factor that translocates from the cytosol to the nucleus to regulate the transcription of genes encoding enzymes required for saturated fatty acid biosynthesis. Fly SREBP-SCAP complex-mediated ER to Golgi transport is inhibited by phosphatidylethanolamine, whereas in mammals it is regulated by sterols and polyunsaturated fatty acids. (Adapted from FBrf0147193.)
Summary (Interactive Fly)

bHLH-leucine zipper transcription factor - membrane bound HLH106 is released by phosphatidylethanolamine, exerting feedback control on the synthesis of fatty acids and phospholipids - cleavage by Drice releases an SREBP fragment to travel to the nucleus where it mediates the increased transcription of target genes needed for lipid synthesis and uptake

Gene Model and Products
Number of Transcripts
4
Number of Unique Polypeptides
1

Please see the JBrowse view of Dmel\SREBP for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Structure
Protein 3D structure   (Predicted by AlphaFold)   (AlphaFold entry Q9VW37)

If you don't see a structure in the viewer, refresh your browser.
Model Confidence:
  • Very high (pLDDT > 90)
  • Confident (90 > pLDDT > 70)
  • Low (70 > pLDDT > 50)
  • Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Experimentally Determined Structures
Crossreferences
Comments on Gene Model

Low-frequency RNA-Seq exon junction(s) not annotated.

Annotated transcripts do not represent all supported alternative splices within 5' UTR.

Gene model reviewed during 5.46

Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
SREBP-RA
FBtr0074873
NM_168815
3841
1113
SREBP-RB
FBtr0074874
NM_168816
3951
1113
SREBP-RC
FBtr0074875
NM_079442
3818
1113
SREBP-RD
FBtr0333877
NM_001275135
3920
1113
Additional Transcript Data and Comments
Reported size (kB)

3.8 (northern blot)

(Theopold et al., 1996)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
UniProt
RefSeq ID
GenBank
SREBP-PA
FBpp0074642
124.5
1113
7.75
Q9VW37
NP_730449
AAF49115
SREBP-PB
FBpp0074643
124.5
1113
7.75
Q9VW37
NP_730450
AAN11631
SREBP-PC
FBpp0074644
124.5
1113
7.75
Q9VW37
NP_524166
AAN11632
SREBP-PD
FBpp0306009
124.5
1113
7.75
Q9VW37
NP_001262064
AGB94757
Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

1113 aa isoforms: SREBP-PA, SREBP-PB, SREBP-PC, SREBP-PD
Additional Polypeptide Data and Comments
Reported size (kDa)

1113 (aa); 130, 85 (kD observed); 125 (kD predicted)

(Theopold et al., 1996)
Comments
External Data
Crossreferences
InterPro - A database of protein families, domains and functional sites
Linkouts
Sequences Consistent with the Gene Model
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\SREBP using the Feature Mapper tool.

External Data
Crossreferences
Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
Linkouts
Expression Data
Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

-1.40

Transcript Expression
Polypeptide Expression
mass spectroscopy
Stage
Tissue/Position (including subcellular localization)
Reference
adult stage
adult head
(Aradska et al., 2015)
western blot
Stage
Tissue/Position (including subcellular localization)
Reference
adult stage
retina
(Tsai et al., 2019)
Additional Descriptive Data

Both the full-length precursor and the activated, nuclear forms of SREBP are detected in the retina.

(Tsai et al., 2019)
Marker for
 
Subcellular Localization
CV Term
Evidence
References
located_in endoplasmic reticulum membrane
inferred from direct assay
(Rosenfeld and Osborne, 1998)
located_in membrane
inferred from direct assay
(Theopold et al., 1996)
located_in nuclear membrane
inferred from direct assay
(Rosenfeld and Osborne, 1998)
located_in nucleus
inferred from direct assay
(Rosenfeld and Osborne, 1998)
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\SREBP in JBrowse
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Bulk Downloads
RNA-Seq RPKM values for all genes
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
Flygut - An atlas of the Drosophila adult midgut
Images
FlyBase Wiki
Image Based Resources
Alleles, Insertions, Transgenic Constructs, and Aberrations
Classical and Insertion Alleles ( 10 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 30 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of SREBP
Transgenic constructs containing regulatory region of SREBP
Aberrations (Deficiencies and Duplications) ( 28 )
Variants
Variant Molecular Consequences
Alleles Representing Disease-Implicated Variants
Phenotypes
For more details about a specific phenotype click on the relevant allele symbol.
Lethality
Allele
cell lethal | germline clone
lethal
lethal (with Df(3L)ED228)
lethal (with Df(3L)kto2)
lethal (with SREBP52)
lethal (with SREBP189)
lethal | heat sensitive, with Scer\GAL4Bx-MS1096
lethal | larval stage, with Scer\GAL4da.G32
lethal | pupal stage, with Scer\GAL4da.G32
lethal | recessive
lethal - all die before end of second instar larval stage | recessive
partially lethal - majority live | conditional
viable, with Dcr-2UAS.cDa, Scer\GAL4elav.PLu
viable, with Scer\GAL4Mef2.PR
viable, with Scer\GAL4pnr-MD237
viable, with Scer\GAL4tin.CΔ4
viable | conditional
Other Phenotypes
Allele
abnormal cell size | larval stage, with Axn127, AxnHMJ23888
abnormal developmental rate, with Scer\GAL4da.G32
abnormal neuroanatomy | adult stage, with Scer\GAL4ninaE.PT
abnormal neuroanatomy | adult stage | somatic clone
abnormal neuroanatomy | adult stage | somatic clone, with Scer\GAL4DIP-γ-MI03222-GAL4
abnormal size | adult stage, with Scer\GAL4ninaE.PT
abnormal size | adult stage, with Scer\GAL4NP0001
decreased body size, with Scer\GAL4da.G32
decreased body size | recessive | second instar larval stage
decreased cell size, with Scer\GAL4en-e16E
decreased cell size | larval stage, with Scer\GAL4ppl.PU
some die during second instar larval stage | recessive
visible, with Scer\GAL4Bx-MS1096
visible, with Scer\GAL4en-e16E
visible | larval stage, with Axn127, AxnHMJ23888
Phenotype manifest in
Allele
adult heart, with Scer\GAL4HCH.Hand
adult heart ventral longitudinal muscle cell, with Scer\GAL4HCH.Hand
adult midgut, with Scer\GAL4NP0001
adult optic lobe glial cell | cell non-autonomous, with Scer\GAL4nSyb.PS
axon | adult stage, with Scer\GAL4ninaE.PT
capitate projection | adult stage, with Scer\GAL4ninaE.PT
dendrite | adult stage | somatic clone
dendrite | adult stage | somatic clone, with Scer\GAL4DIP-γ-MI03222-GAL4
dense core granule | adult stage, with Scer\GAL4ninaE.PT
distal medullary amacrine neuron Dm8 | adult stage | somatic clone
distal medullary amacrine neuron Dm8 | adult stage | somatic clone, with Scer\GAL4DIP-γ-MI03222-GAL4
egg chamber | germline clone
eye photoreceptor cell | adult stage, with Scer\GAL4ninaE.PT
female germline cell | absent, with Scer\GAL4VP16.nanos.UTR
larval abdomen, with Axn127, AxnHMJ23888
larval fat cell, with Axn127, AxnHMJ23888
larval fat cell of larval fat body, with Scer\GAL4ppl.PU
lipid droplet | adult stage, with Scer\GAL4NP0001
lipid droplet | adult stage | cell non-autonomous, with Scer\GAL4nSyb.PS
lipid droplet | adult stage | increased number, with Scer\GAL4nSyb.PS
neuronal cell body | adult stage, with Scer\GAL4ninaE.PT
ommatidium | adult stage, with Scer\GAL4nSyb.PS
optic cartridge | adult stage, with Scer\GAL4ninaE.PT
synaptic vesicle | adult stage, with Scer\GAL4ninaE.PT
T-bar | adult stage, with Scer\GAL4ninaE.PT
wing, with Scer\GAL4Bx-MS1096
wing, with Scer\GAL4da.G32
wing blade posterior compartment, with Scer\GAL4en-e16E
Orthologs
Downloads
Download All DIOPT Orthologs
Human Orthologs (via DIOPT v9.1)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
Domainoid
eggNOG
Hieranoid
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Complementation?
Transgene?
Homo sapiens (Human) (14)
Hsap\SREBF1
13 of 14
Yes
Yes
Hsap\SREBF2
12 of 14
No
Yes
4  
Hsap\MYCN
2 of 14
No
No
Hsap\CCDC169-SOHLH2
1 of 14
No
Yes
Hsap\MAX
1 of 14
No
No
Hsap\MITF
1 of 14
No
No
1  
Hsap\MLX
1 of 14
No
No
1  
Hsap\MNT
1 of 14
No
No
Hsap\MYC
1 of 14
No
No
6  
Hsap\SOHLH2
1 of 14
No
Yes
Hsap\TFE3
1 of 14
No
No
1  
Hsap\USF1
1 of 14
No
No
Hsap\USF2
1 of 14
No
No
Hsap\USF3
1 of 14
No
Yes
Model Organism Orthologs (via DIOPT v9.1)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
Domainoid
eggNOG
Hieranoid
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Complementation?
Transgene?
Rattus norvegicus (Norway rat) (8)
Rnor\Srebf1
13 of 14
Yes
Yes
Rnor\Srebf2
12 of 14
No
Yes
Rnor\Mitf
1 of 14
No
No
Rnor\Mycs
1 of 14
No
No
Rnor\Tfe3
1 of 14
No
No
Rnor\Tfec
1 of 14
No
No
Rnor\Usf1
1 of 14
No
No
Rnor\Usf2
1 of 14
No
No
Mus musculus (laboratory mouse) (9)
Mmus\Srebf1
12 of 14
Yes
Yes
Mmus\Srebf2
12 of 14
Yes
Yes
Mmus\Mitf
1 of 14
No
No
Mmus\Mycn
1 of 14
No
No
Mmus\Mycs
1 of 14
No
No
Mmus\Tfe3
1 of 14
No
No
Mmus\Tfec
1 of 14
No
No
Mmus\Usf1
1 of 14
No
No
Mmus\Usf2
1 of 14
No
No
Xenopus tropicalis (Western clawed frog) (8)
Xtro\srebf1
7 of 13
Yes
Yes
Xtro\srebf2
7 of 13
Yes
Yes
Xtro\mitf
1 of 13
No
No
Xtro\mnt
1 of 13
No
No
Xtro\myc
1 of 13
No
No
Xtro\nr5a2
1 of 13
No
No
Xtro\tfeb
1 of 13
No
No
Xtro\usf3
1 of 13
No
Yes
Danio rerio (Zebrafish) (9)
Drer\srebf1
13 of 14
Yes
Yes
Drer\srebf2
12 of 14
No
Yes
Drer\mitfa
1 of 14
No
No
Drer\mitfb
1 of 14
No
No
Drer\tfe3a
1 of 14
No
No
Drer\tfe3b
1 of 14
No
No
Drer\tfeb
1 of 14
No
No
Drer\tfec
1 of 14
No
No
Drer\usf2
1 of 14
No
No
Caenorhabditis elegans (Nematode, roundworm) (4)
Cele\sbp-1
13 of 14
Yes
Yes
Cele\hlh-30
1 of 14
No
No
Cele\mml-1
1 of 14
No
No
Cele\mxl-1
1 of 14
No
No
Anopheles gambiae (African malaria mosquito) (6)
Agam\AgaP_AGAP000076
12 of 12
Yes
Yes
Agam\AgaP_AGAP000682
1 of 12
No
No
Agam\AgaP_AGAP003177
1 of 12
No
No
Agam\AgaP_AGAP009806
1 of 12
No
No
Agam\AgaP_AGAP013107
1 of 12
No
No
Agam\AgaP_AGAP013301
1 of 12
No
No
Arabidopsis thaliana (thale-cress) (12)
Atha\AT4G16430
1 of 13
Yes
No
Atha\AT5G43175
1 of 13
Yes
Yes
Atha\AT5G64980
1 of 13
Yes
Yes
Atha\BIM1
1 of 13
Yes
Yes
Atha\BIM2
1 of 13
Yes
No
Atha\BIM3
1 of 13
Yes
Yes
Atha\GL3
1 of 13
Yes
No
Atha\MYC3
1 of 13
Yes
No
Atha\MYC4
1 of 13
Yes
No
Atha\PIF3
1 of 13
Yes
No
Atha\PIL5
1 of 13
Yes
No
Atha\SPT
1 of 13
Yes
Yes
Saccharomyces cerevisiae (Brewer's yeast) (3)
Scer\HMS1
3 of 13
Yes
Yes
Scer\TYE7
3 of 13
Yes
Yes
Scer\RTG1
1 of 13
No
Yes
Schizosaccharomyces pombe (Fission yeast) (3)
Spom\sre2
4 of 12
Yes
Yes
Spom\sre1
3 of 12
No
Yes
Spom\SPAC3F10.12c
1 of 12
No
No
Escherichia coli (enterobacterium) (0)
Other Organism Orthologs (via OrthoDB)
Data provided directly from OrthoDB:SREBP. Refer to their site for version information.
Paralogs
Downloads
Download All DIOPT Paralogs
Paralogs (via DIOPT v9.1)
Gene Symbol
Score
Source
Compara
Domainoid
eggNOG
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Drosophila melanogaster (Fruit fly) (4)
bigmax
1 of 13
Max
1 of 13
Mitf
1 of 13
Mondo
1 of 13
Human Disease Associations
FlyBase Human Disease Model Reports
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 2 )
Potential Models Based on Orthology ( 0 )
Human Ortholog
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 2 )
Allele
Disease
Interaction
References
SREBP52
ameliorates  heart conduction disease
modeled by eas2
(Lim et al., 2011)
SREBP189
ameliorates  heart conduction disease
modeled by eas2
(Lim et al., 2011)
Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)
Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
Homo sapiens (Human)
Gene name
Score
OMIM
OMIM Phenotype
DO term
Complementation?
Transgene?
SREBF1; sterol regulatory element binding transcription factor 1
13 of 14
184756
    SREBF2; sterol regulatory element binding transcription factor 2
    12 of 14
    600481
         
        Functional Complementation Data
        Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
        Interactions
        Summary of Physical Interactions
        Interaction Browsers
        View in FlyBase Interactions Browser   View in MIST tool (external link)
        Please see the Physical Interaction reports below for full details
        protein-protein
        Physical Interaction
        Assay
        References
        SREBP - Cdk8
        two hybrid, pull down, western blot
        (Li et al., 2022)
        SREBP - MED15
        pull down, western blot, two hybrid
        (Li et al., 2022)
        SREBP - lms
        two hybrid array
        (Shokri et al., 2019)
        Summary of Genetic Interactions
        Interaction Browsers
        View in FlyBase Interactions Browser   View in MIST tool (external link)
        Please look at the allele data for full details of the genetic interactions
        Starting gene(s)
        Interaction type
        Interacting gene(s)
        Reference
        SREBP
        suppressible
        Ldh
        (Liu et al., 2017)
        SREBP
        suppressible
        out
        (Liu et al., 2017)
        SREBP
        suppressible
        Pdha1
        (Liu et al., 2017)
        SREBP
        suppressible
        Sln
        (Liu et al., 2017)
        Starting gene(s)
        Interaction type
        Interacting gene(s)
        Reference
        Axn
        suppressible
        pan|SREBP
        (Zhang et al., 2017)
        Axn
        suppressible
        α-Cat|SREBP
        (Zhang et al., 2017)
        Axn
        suppressible
        SREBP|lgs
        (Zhang et al., 2017)
        Ctps
        suppressible
        SREBP
        (Liu et al., 2023)
        eas
        suppressible
        SREBP
        (Lim et al., 2011)
        mir-210
        suppressible
        SREBP
        (Lyu et al., 2021)
        mTor
        suppressible
        SREBP
        (Luo et al., 2020)
        S2P
        enhanceable
        SREBP
        (Amarneh et al., 2009)
        External Data
        Linkouts
        BioGRID - A database of protein and genetic interactions.
        DroID - A comprehensive database of gene and protein interactions.
        MIST (protein-protein) - An integrated Molecular Interaction Database
        Pathways
        Signaling Pathways (FlyBase)
        Metabolic Pathways
        FlyBase
        External Links
        Reactome Metabolic Pathways - An open-source, open access, manually curated and peer-reviewed metabolic pathway database.
        External Data
        Linkouts
        Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
        Class of Gene
        Genomic Location and Detailed Mapping Data
        Chromosome (arm)
        3L
        Recombination map
        3-46
        Cytogenetic map
        76C5-76C6
        Sequence location
        FlyBase Computed Cytological Location
        Cytogenetic map
        Evidence for location
        76C5-76C6
        Experimentally Determined Cytological Location
        Cytogenetic map
        Notes
        References
        Experimentally Determined Recombination Data
        Location

        3-46

        (FlyBase, 2016)

        3-43.1

        (Comeron et al., 2012)

        3-

        (Horn et al., 2003)
        Left of (cM)
        Right of (cM)
        Notes
        Stocks and Reagents
        Stocks (35)
        Genomic Clones (13)
         

        Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

        cDNA Clones (34)
         

        Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

        cDNA clones, fully sequenced
        BDGP DGC clones
        Other clones
          Drosophila Genomics Resource Center cDNA clones

          For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

          cDNA Clones, End Sequenced (ESTs)
          BDGP DGC clones
          Other clones
          RNAi and Array Information
          Linkouts
          DRSC - Results frm RNAi screens
          Antibody Information
          Laboratory Generated Antibodies
           

          polyclonal

          (Xie et al., 2015)
          Commercially Available Antibodies
           
          Cell Line Information
          Publicly Available Cell Lines
           
            Other Stable Cell Lines
             
              Other Comments

              SREBP mutants exhibit lipid droplet accumulation in glia, but this does not lead to premature neurodegeneration.

              (Liu et al., 2015)

              S2 cells treated with dsRNA generated against this gene show reduced phagocytosis of Candida albicans compared to untreated cells.

              (Stroschein-Stevenson et al., 2006)

              RNAi generated by PCR using primers directed to this gene causes a cell growth and viability phenotype when assayed in Kc167 and S2R+ cells.

              (Boutros et al., 2004)

              Phosphatidylethanolamine controls the release of HLH106 protein from cell membranes.

              (Dobrosotskaya et al., 2002)

              Area matching Drosophila HLH106 gene, Acc. No. U38238.

              (Davies, 2001.3.15)

              HLH106, a SREBP homolog from Drosophila, has been isolated. The similarity in the domain structure to vertebrate SREBP is a strong argument that the proteins have related functions.

              (Theopold et al., 1996)

              HLH106 is related to human sterol regulatory protein SREBP-1.

              (Ekengren et al., 1995)
              Relationship to Other Genes
              Source for database merge of

              Source for merge of: HLH106 l(3)76BDw

              (Kennison, 2009.7.23)
              Additional comments
              Nomenclature History
              Source for database identify of

              Source for identity of: SREBP HLH106

              (FlyBase, 2009-)
              Nomenclature comments

              Renamed from 'HLH106' to 'SREBP' to be more informative and reflect clear preference in the literature.

              (FlyBase, 2009-)
              Etymology
              Synonyms and Secondary IDs (23)
              Reported As
              Symbol Synonym
              CG8522
              (Wu et al., 2023, Ward and Moehring, 2021, Chiang et al., 2016, Hosono et al., 2015, Kim et al., 2015, Schertel et al., 2013, Ni et al., 2011.7.19, Perkins et al., 2009.1.15, Molnar et al., 2006, Ramet et al., 2002, Seegmiller et al., 2002)
              HLH106
              (Liang et al., 2021, Chung et al., 2017, Brewer-Jensen et al., 2016, Chen et al., 2014, Gonzalez et al., 2014, Bonke et al., 2013, Lee et al., 2013, Lindsley et al., 2013, Schertel et al., 2013, Rawson, 2012.9.3, Grimberg et al., 2011, White et al., 2011, Cooper et al., 2010, D'Ambrosio and Vale, 2010, Pospisilik et al., 2010, Guo et al., 2008, Porstmann et al., 2008, Zhou et al., 2008, Kunte et al., 2006, Stroschein-Stevenson et al., 2006, Suh et al., 2006)
              HlH106
              (Molnar et al., 2006)
              SREBF1
              (Wangler et al., 2017, Ivatt and Whitworth, 2014, Ivatt et al., 2014)
              SREBP
              (Sheng et al., 2025, Berg et al., 2024, Goodman et al., 2024, Kurhaluk, 2024, Le et al., 2024, Liu et al., 2024, Moulton et al., 2024, Kim et al., 2023, Li et al., 2023, Wu et al., 2023, Carlson et al., 2022, Charroux and Royet, 2022, Goodman and Bellen, 2022, Wang et al., 2022, Bonfini et al., 2021, Ekure et al., 2021, He et al., 2021, Heier et al., 2021, Jacomin et al., 2021, Kilo et al., 2021, Liu and Han, 2021.4.14, Lyu et al., 2021, Moraes and Montagne, 2021, Pang et al., 2021, Ward and Moehring, 2021, Ågren et al., 2020, Luo et al., 2020, Martínez et al., 2020, Toprak et al., 2020, Zipper et al., 2020, Chen et al., 2019, Mirth et al., 2019, Sênos Demarco et al., 2019, Shokri et al., 2019, Su et al., 2019, Swevers, 2019, Tsai et al., 2019, Westfall et al., 2019, Gene Disruption Project members, 2018-, Lee et al., 2018, Lehmann, 2018, Park et al., 2018, Swevers et al., 2018, Westfall et al., 2018, Yin et al., 2018, Chng et al., 2017, Liu and Jin, 2017, Sieber and Spradling, 2017, Transgenic RNAi Project members, 2017-, Yan et al., 2017, Chiang et al., 2016, Diop and Bodmer, 2015, Diop et al., 2015, Liu et al., 2015, model organism Encyclopedia of Regulatory Network (modERN) Project, 2015-, Sanchez-Alvarez et al., 2015, Schertel et al., 2015, Sieber and Spradling, 2015, Xie et al., 2015, Song et al., 2014, Bonke et al., 2013, Rawson, 2013, Niwa and Niwa, 2011, D'Ambrosio and Vale, 2010, Bauer et al., 2009, Guo et al., 2008, Callejo et al., 2007, Matthews and Rawson, 2007, Cherry et al., 2006, Dorner et al., 2006, Matthews et al., 2006, Suh et al., 2006, Higaki et al., 2004, Kunte et al., 2004, Nohturfft and Losick, 2002)
              SREBP1
              (Fangninou et al., 2024, Vos and Klein, 2021)
              Srebp
              (Liu et al., 2023, Mariano et al., 2023, He et al., 2021)
              dSREBP
              (Singh and Agrawal, 2022, Bertolio et al., 2019, Álvarez-Rendón et al., 2018, Brookheart and Duncan, 2016, Zhao et al., 2012, Lim et al., 2011, Kühnlein, 2010, Lee et al., 2010, Amarneh et al., 2009, Matthews et al., 2009, Porstmann et al., 2008, Dong et al., 2007, Kunte et al., 2006, Kunte et al., 2006, Kunte et al., 2005, Matthews et al., 2005, Dobrosotskaya et al., 2003, Rawson, 2003, Rawson et al., 2003, Dobrosotskaya et al., 2002, Seegmiller et al., 2002, Seegmiller et al., 2002)
              dSrebp
              (Montooth et al., 2006)
              dsrebp
              (Yan et al., 2023, Ozdemir and Rawson, 2011, Matthews et al., 2010)
              l(3)76BDw
              (Cooper et al., 2010, Cook, 2008.12.1)
              srebp
              (Cao et al., 2023, Zhang et al., 2021, Yu et al., 2020, Sundararajan and Miller, 2018, Meltzer et al., 2017, Wei et al., 2017, Belgacem and Martin, 2007)
              Name Synonyms
              Drosophila sterol regulatory element binding protein
              (Montooth et al., 2006)
              Helix loop helix protein 106
              (Ekengren et al., 1995)
              Sterol Regulatory Element Binding Protein
              (Matthews et al., 2010)
              Sterol regulatory element binding protein
              (Liu et al., 2015)
              Sterol regulatory element-binding protein
              (Dobrosotskaya et al., 2002)
              lethal (3) 76BDw
              sterol regulatory element binding protein
              (Diop and Bodmer, 2015)
              sterol regulatory element-binding protein
              (D'Ambrosio and Vale, 2010)
              sterol response element binding protein
              (Sundararajan and Miller, 2018)
              sterol-responsive element-binding protein
              (Bauer et al., 2009)
              transcription factor Sterol regulatory element binding protein
              (Bonke et al., 2013)
              Secondary FlyBase IDs
              • FBgn0015234
              • FBgn0063456
              • FBgn0260652
              Datasets (0)
              Study focus (0)
              Experimental Role
              Project
              Project Type
              Title
              Study result (0)
              Result
              Result Type
              Title
              External Crossreferences and Linkouts ( 48 )
              Sequence Crossreferences
              NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
              GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
              GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
              RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
              UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.
              UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information
              Other crossreferences
              AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.
              BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
              DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
              EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
              FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
              InterPro - A database of protein families, domains and functional sites
              KEGG Genes - Molecular building blocks of life in the genomic space.
              MARRVEL_MODEL - MARRVEL (model organism gene)
              Linkouts
              BioGRID - A database of protein and genetic interactions.
              Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones
              DroID - A comprehensive database of gene and protein interactions.
              DRSC - Results frm RNAi screens
              Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
              FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
              FlyCyc Genes - Genes from a BioCyc PGDB for Dmel
              Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
              Flygut - An atlas of the Drosophila adult midgut
              FlyMet - A comprehensive tissue-specific metabolomics resource for Drosophila.
              iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)
              Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution
              MIST (protein-protein) - An integrated Molecular Interaction Database
              Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
              Reactome Metabolic Pathways - An open-source, open access, manually curated and peer-reviewed metabolic pathway database.
              References (207)