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Gene Dmel\verm

General Information
Symbol	Dmel\verm	Species	D. melanogaster
Name	vermiform	Annotation symbol	CG8756
Feature type	protein_coding_gene	FlyBase ID	FBgn0261341
Gene Model Status	Current	Stock availability	5 publicly available
Also Known As	N63, LCBP1, hlm, l(3)76BDx
Genomic Location
Chromosome (arm)	3L	Recombination map
Cytogenetic map	76C2-76C3	Sequence location	3L:19,683,133..19,688,359 [-]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents Beta	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene vermiform is referred to in FlyBase by the symbol Dmel\verm (CG8756, FBgn0261341). It is a protein_coding_gene from Drosophila melanogaster. There is experimental evidence that it has the molecular function: chitin binding; chitin deacetylase activity. There is experimental evidence that it is involved in the biological process: dorsal trunk growth, open tracheal system; trachea morphogenesis; visual behavior; open tracheal system development; regulation of tube length, open tracheal system. 12 alleles are reported. The phenotypes of these alleles are annotated with: embryonic/first instar larval cuticle; embryonic/larval trachea; cuticle; embryonic/larval dorsal trunk; embryonic/larval tracheal system. It has 6 annotated transcripts and 6 annotated polypeptides. Protein features are: Chitin binding domain; Glycoside hydrolase/deacetylase, beta/alpha-barrel; Low-density lipoprotein (LDL) receptor class A repeat; Low-density lipoprotein (LDL) receptor class A, conserved site; Polysaccharide deacetylase. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of very high expression to a trough of low expression. Peak expression observed within 06-24 hour embryonic stages, at stages throughout the larval period, at stages throughout the pupal period. Summary of FlyAtlas Anatomical Expression Data: Expression at high levels in the following post-embryonic organs or tissues: larval hindgut, larval trachea, larval carcass. Comments on Affy2 ProbeSet: ProbeSet 1624035_a_at completely aligns to an exonic region common to each of the 6 FlyBase-annotated transcript isoforms of verm. Gene sequence location is 3L:19683133..19688360.
User Contributed Data
	Beta version, feedback welcome
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 76C2-76C3   Left limit from in situ hybridisation (FBrf0080573) Right limit from in situ hybridisation (FBrf0080573)
Experimentally Determined Cytological Location
Cytogenetic map Notes References 76C2-76C3     (Pollock, 1998.3.10) 76C2-76C3     (McKay et al., 1996) 76C2-76C3   (determined by in situ hybridisation)   (McKay, 1995) 76C-76C   (determined by in situ hybridisation)   (McKay and Pollock, 1995)
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\verm for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
	Gene model reviewed during 5.45 Gene model reviewed during 5.51 Low-frequency RNA-seq exon junction(s) not annotated. Annotated transcripts do not represent all possible combinations of alternative exons and/or alternative promoters.
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) verm-RF FBtr0302334  NM_001169999   2295   104 verm-RG FBtr0302335  NM_168809   2168   525
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein verm-PF   FBpp0291539   11.7   104   4.34     NP_001163470   ACZ94741 verm-PG   FBpp0291540   59.6   525   4.83     NP_730442   AAF49121
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Low-density lipoprotein (LDL) receptor class A, conserved site (IPR023415) Chitin binding domain (IPR002557) Low-density lipoprotein (LDL) receptor class A repeat (IPR002172) Polysaccharide deacetylase (IPR002509) Glycoside hydrolase/deacetylase, beta/alpha-barrel (IPR011330)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA567703   AA820647   AA941640   AE014296 AAF49121   AE014296 ACZ94741   AI109924   AI257783   AI258444   AI259288   AI259746   AI259845   AI259952   AI260007   AI296791   AI296985   AI297273   AI455484   AI518560   AK283588   AK284637   AW943978   AY118597 AAM49966   BF485660   BF500912   BF500991   BH900957   BI164360   BI215610   BI216198   BI216938   BI231634   BI233303   BI236304   BI240504   BI358165   BI361588   BI362901   BI364688   BI368705   BI483770   BI484177   BI484767   BI563851   BI564146   BI566788   BI566793   BI568356   BI571055   BI572532   BI580839   BI584536   BI584729   BI585087   BI591111   BI591340   BI591640   BI615174   BI615733   BI619466   BI622834   BT016093 AAV36978   BT021357   BT126045   BT126090   BT126094   CK657159   CK658123   CK658353   CK658671   CK659483   CK659513   CK661115   CO178109   CO188284   CO188688   CO190215   CO265694   CO270498   CO280424   CO281658   CO281784   CO282954   CO286606   CO287273   CO291514   CO293468   CO296023   CO298117   CO303952   CO305203   CO307057   CO308306   CO308458   CO312380   CO313595   CO317267   CO319636   CO323940   CO328694   CO342519   DQ665308 ABI95428   EC058056   EC058255   EC059837   EC061395   EC069180   EC069287   EC073598   EC081104   EC084922   EC085362   EC087814   EC088709   EC089515   EC089973   EC195561   EC200628   EC202741   EC203552   EC206181   EC209913   EC213405   EC217991   EC219793   EC219887   EC224733   EC229564   EC233794   EC235422   EC236753   EC236889   EC238214   EC246298   EC246671   EC247146   EC253584   EL874911   EL874912   EL875027   EL875028   EL875140   EL875141   ES688816   ES688999   ES689205   ES689634   ES689828   ES695541   GH955939
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL	Q8IQU1 Q9VW30 Q9VW31 E1JI40 E1JI41 Q8MSU2 Q06RG9
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
in situ Stage Tissue/Position (including subcellular localization) Reference embryonic stage   epithelial cell   • cytoplasm (Lecuyer et al., 2007) Comment:excluded from blastoderm layer epithelium   • cytoplasm (Lecuyer et al., 2007) Comment:excluded from blastoderm layer embryonic stage 11 -- 13   presumptive embryonic/larval tracheal system   (McKay et al., 2008) prepupal stage P4   retina   (McKay et al., 2008) Comment:12h APF pharate adult stage P9   retina   (McKay et al., 2008) Comment:65h APF adult stage   retina   (McKay et al., 2008)
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Polypeptide Expression
immunolocalization Stage Tissue/Position (including subcellular localization) Reference adult stage   eye photoreceptor cell   (McKay et al., 2008) retina | restricted   (McKay et al., 2008) lamina | restricted   (McKay et al., 2008) western blot Stage Tissue/Position (including subcellular localization) Reference adult stage   adult head   (McKay et al., 2008)
Additional Descriptive Data
	verm is detected on the surface of photoreceptors in the adult retina. (McKay et al., 2008)
Marker for
Subcellular Localization (GO Cellular Component)
CV term Evidence References
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools
Reference	See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes.
FlyAtlas Anatomy Microarray
FlyAtlas Anatomical Expression Data (FlyAtlas-RNA.adult) (FlyAtlas-RNA.larva)    Styles Linear Logarithmic Heatmap Back-to-back    Scales gene max expression Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Expression at high levels in the following post-embryonic organs or tissues: larval hindgut, larval trachea, larval carcass. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (>999.999) Linear, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    14.075 Larval Midgut    18.3 Larval Hindgut    1039.1 Larval Malpighian Tubules    1.8 Larval Fat Body    9.6 Larval Salivary Gland    39.9 Larval Trachea    1365.375 Larval Carcass    2323.2 Adult Head    24 Adult Eye    24.4 Adult Brain    1.4 Adult Thoracic-Abdominal Ganglion    2.3 Adult Crop    37.3 Adult Midgut    3.3 Adult Hindgut    13.9 Adult Malpighian Tubules    1.8 Adult Fat Body    2.3 Adult Salivary Gland    4.8 Adult Heart    8.3 Adult VirginFemale Spermatheca    1.9 Adult InseminatedFemale Spermatheca    3 Adult Ovary    2 Adult Testis    26.2 Adult Male Accessory Gland    2.2 Adult Carcass    65.1 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    14.075 Larval Midgut    18.3 Larval Hindgut  (1039.1) Larval Malpighian Tubules    1.8 Larval Fat Body    9.6 Larval Salivary Gland    39.9 Larval Trachea  (1365.375) Larval Carcass  (2323.2) Adult Head    24 Adult Eye    24.4 Adult Brain    1.4 Adult Thoracic-Abdominal Ganglion    2.3 Adult Crop    37.3 Adult Midgut    3.3 Adult Hindgut    13.9 Adult Malpighian Tubules    1.8 Adult Fat Body    2.3 Adult Salivary Gland    4.8 Adult Heart    8.3 Adult VirginFemale Spermatheca    1.9 Adult InseminatedFemale Spermatheca    3 Adult Ovary    2 Adult Testis    26.2 Adult Male Accessory Gland    2.2 Adult Carcass    65.1 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    14.075 Larval Midgut    18.3 Larval Hindgut  1039.1 Larval Malpighian Tubules    1.8 Larval Fat Body    9.6 Larval Salivary Gland    39.9 Larval Trachea  (1365.375) Larval Carcass  (2323.2) Adult Head    24 Adult Eye    24.4 Adult Brain    1.4 Adult Thoracic-Abdominal Ganglion    2.3 Adult Crop    37.3 Adult Midgut    3.3 Adult Hindgut    13.9 Adult Malpighian Tubules    1.8 Adult Fat Body    2.3 Adult Salivary Gland    4.8 Adult Heart    8.3 Adult VirginFemale Spermatheca    1.9 Adult InseminatedFemale Spermatheca    3 Adult Ovary    2 Adult Testis    26.2 Adult Male Accessory Gland    2.2 Adult Carcass    65.1 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    14.075 Larval Midgut    18.3 Larval Hindgut    1039.1 Larval Malpighian Tubules    1.8 Larval Fat Body    9.6 Larval Salivary Gland    39.9 Larval Trachea    1365.375 Larval Carcass    2323.2 Adult Head    24 Adult Eye    24.4 Adult Brain    1.4 Adult Thoracic-Abdominal Ganglion    2.3 Adult Crop    37.3 Adult Midgut    3.3 Adult Hindgut    13.9 Adult Malpighian Tubules    1.8 Adult Fat Body    2.3 Adult Salivary Gland    4.8 Adult Heart    8.3 Adult VirginFemale Spermatheca    1.9 Adult InseminatedFemale Spermatheca    3 Adult Ovary    2 Adult Testis    26.2 Adult Male Accessory Gland    2.2 Adult Carcass    65.1 Expression Level Scale  Very high  log, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    14.075 Larval Midgut    18.3 Larval Hindgut    1039.1 Larval Malpighian Tubules    1.8 Larval Fat Body    9.6 Larval Salivary Gland    39.9 Larval Trachea    1365.375 Larval Carcass    2323.2 Adult Head    24 Adult Eye    24.4 Adult Brain    1.4 Adult Thoracic-Abdominal Ganglion    2.3 Adult Crop    37.3 Adult Midgut    3.3 Adult Hindgut    13.9 Adult Malpighian Tubules    1.8 Adult Fat Body    2.3 Adult Salivary Gland    4.8 Adult Heart    8.3 Adult VirginFemale Spermatheca    1.9 Adult InseminatedFemale Spermatheca    3 Adult Ovary    2 Adult Testis    26.2 Adult Male Accessory Gland    2.2 Adult Carcass    65.1 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    14.075 Larval Midgut    18.3 Larval Hindgut  (1039.1) Larval Malpighian Tubules    1.8 Larval Fat Body    9.6 Larval Salivary Gland    39.9 Larval Trachea  (1365.375) Larval Carcass  (2323.2) Adult Head    24 Adult Eye    24.4 Adult Brain    1.4 Adult Thoracic-Abdominal Ganglion    2.3 Adult Crop    37.3 Adult Midgut    3.3 Adult Hindgut    13.9 Adult Malpighian Tubules    1.8 Adult Fat Body    2.3 Adult Salivary Gland    4.8 Adult Heart    8.3 Adult VirginFemale Spermatheca    1.9 Adult InseminatedFemale Spermatheca    3 Adult Ovary    2 Adult Testis    26.2 Adult Male Accessory Gland    2.2 Adult Carcass    65.1 Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    14.075 Larval Midgut    18.3 Larval Hindgut  1039.1 Larval Malpighian Tubules    1.8 Larval Fat Body    9.6 Larval Salivary Gland    39.9 Larval Trachea  1365.375 Larval Carcass  (2323.2) Adult Head    24 Adult Eye    24.4 Adult Brain    1.4 Adult Thoracic-Abdominal Ganglion    2.3 Adult Crop    37.3 Adult Midgut    3.3 Adult Hindgut    13.9 Adult Malpighian Tubules    1.8 Adult Fat Body    2.3 Adult Salivary Gland    4.8 Adult Heart    8.3 Adult VirginFemale Spermatheca    1.9 Adult InseminatedFemale Spermatheca    3 Adult Ovary    2 Adult Testis    26.2 Adult Male Accessory Gland    2.2 Adult Carcass    65.1 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    14.075 Larval Midgut    18.3 Larval Hindgut    1039.1 Larval Malpighian Tubules    1.8 Larval Fat Body    9.6 Larval Salivary Gland    39.9 Larval Trachea    1365.375 Larval Carcass    2323.2 Adult Head    24 Adult Eye    24.4 Adult Brain    1.4 Adult Thoracic-Abdominal Ganglion    2.3 Adult Crop    37.3 Adult Midgut    3.3 Adult Hindgut    13.9 Adult Malpighian Tubules    1.8 Adult Fat Body    2.3 Adult Salivary Gland    4.8 Adult Heart    8.3 Adult VirginFemale Spermatheca    1.9 Adult InseminatedFemale Spermatheca    3 Adult Ovary    2 Adult Testis    26.2 Adult Male Accessory Gland    2.2 Adult Carcass    65.1 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    no informative data   NA  Eye    24.4   NA  Brain    1.4   no informative data  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    2.3   NA  Crop    no informative data   no informative data  Midgut    3.3   1039.1  Hindgut    no informative data   1.8  Malpighian Tubules    1.8   9.6  Fat Body    2.3   no informative data  Salivary Gland    4.8   NA  Heart    8.3   1365.375  Trachea    NA   NA  VirginFemale Spermatheca    1.9   NA  InseminatedFemale Spermatheca    3   NA  Ovary    2   NA  Testis    no informative data   NA  Male Accessory Gland    2.2   2323.2  Carcass    no informative data FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
modENCODE Anatomy RNA-Seq
modENCODE Tissue Expression Data (modENCODE_mRNA-Seq_tissues)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    163 central nervous system, larvae L3    33 central nervous system, pupae P8    109 head, virgin 1-day female    74 head, virgin 4-day female    6 head, virgin 20-day female    6 head, mated 1-day female    28 head, mated 4-day female    3 head, mated 20-day female    4 head, mated 1-day male    54 head, mated 4-day male    6 head, mated 20-day male    7 salivary gland, larvae L3 wandering    2 salivary gland, white prepupae    22 digestive system, larvae L3 wandering    20 digestive system, 1-day adult    3 digestive system, 4-day adult    3 digestive system, 20-day adult    1 fat body, larvae L3 wandering    5 fat body, white prepupae    29 fat body, pupae P8    222 carcass, larvae L3 wandering    134 carcass, 1-day adult    42 carcass, 4-day adult    11 carcass, 20-day adult    6 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    3 accessory gland, mated 4-day male    2 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering  (163) central nervous system, larvae L3  (33) central nervous system, pupae P8  (109) head, virgin 1-day female  (74) head, virgin 4-day female    6 head, virgin 20-day female    6 head, mated 1-day female  (28) head, mated 4-day female    3 head, mated 20-day female    4 head, mated 1-day male  (54) head, mated 4-day male    6 head, mated 20-day male    7 salivary gland, larvae L3 wandering    2 salivary gland, white prepupae    22 digestive system, larvae L3 wandering    20 digestive system, 1-day adult    3 digestive system, 4-day adult    3 digestive system, 20-day adult    1 fat body, larvae L3 wandering    5 fat body, white prepupae  (29) fat body, pupae P8  (222) carcass, larvae L3 wandering  (134) carcass, 1-day adult  (42) carcass, 4-day adult    11 carcass, 20-day adult    6 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    3 accessory gland, mated 4-day male    2 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering  (163) central nervous system, larvae L3    33 central nervous system, pupae P8  (109) head, virgin 1-day female    74 head, virgin 4-day female    6 head, virgin 20-day female    6 head, mated 1-day female    28 head, mated 4-day female    3 head, mated 20-day female    4 head, mated 1-day male    54 head, mated 4-day male    6 head, mated 20-day male    7 salivary gland, larvae L3 wandering    2 salivary gland, white prepupae    22 digestive system, larvae L3 wandering    20 digestive system, 1-day adult    3 digestive system, 4-day adult    3 digestive system, 20-day adult    1 fat body, larvae L3 wandering    5 fat body, white prepupae    29 fat body, pupae P8  (222) carcass, larvae L3 wandering  (134) carcass, 1-day adult    42 carcass, 4-day adult    11 carcass, 20-day adult    6 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    3 accessory gland, mated 4-day male    2 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    163 central nervous system, larvae L3    33 central nervous system, pupae P8    109 head, virgin 1-day female    74 head, virgin 4-day female    6 head, virgin 20-day female    6 head, mated 1-day female    28 head, mated 4-day female    3 head, mated 20-day female    4 head, mated 1-day male    54 head, mated 4-day male    6 head, mated 20-day male    7 salivary gland, larvae L3 wandering    2 salivary gland, white prepupae    22 digestive system, larvae L3 wandering    20 digestive system, 1-day adult    3 digestive system, 4-day adult    3 digestive system, 20-day adult    1 fat body, larvae L3 wandering    5 fat body, white prepupae    29 fat body, pupae P8    222 carcass, larvae L3 wandering    134 carcass, 1-day adult    42 carcass, 4-day adult    11 carcass, 20-day adult    6 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    3 accessory gland, mated 4-day male    2 Expression Level Scale  Extremely high  log, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    163 central nervous system, larvae L3    33 central nervous system, pupae P8    109 head, virgin 1-day female    74 head, virgin 4-day female    6 head, virgin 20-day female    6 head, mated 1-day female    28 head, mated 4-day female    3 head, mated 20-day female    4 head, mated 1-day male    54 head, mated 4-day male    6 head, mated 20-day male    7 salivary gland, larvae L3 wandering    2 salivary gland, white prepupae    22 digestive system, larvae L3 wandering    20 digestive system, 1-day adult    3 digestive system, 4-day adult    3 digestive system, 20-day adult    1 fat body, larvae L3 wandering    5 fat body, white prepupae    29 fat body, pupae P8    222 carcass, larvae L3 wandering    134 carcass, 1-day adult    42 carcass, 4-day adult    11 carcass, 20-day adult    6 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    3 accessory gland, mated 4-day male    2 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering  (163) central nervous system, larvae L3  (33) central nervous system, pupae P8  (109) head, virgin 1-day female  (74) head, virgin 4-day female    6 head, virgin 20-day female    6 head, mated 1-day female  28 head, mated 4-day female    3 head, mated 20-day female    4 head, mated 1-day male  (54) head, mated 4-day male    6 head, mated 20-day male    7 salivary gland, larvae L3 wandering    2 salivary gland, white prepupae    22 digestive system, larvae L3 wandering    20 digestive system, 1-day adult    3 digestive system, 4-day adult    3 digestive system, 20-day adult    1 fat body, larvae L3 wandering    5 fat body, white prepupae  29 fat body, pupae P8  (222) carcass, larvae L3 wandering  (134) carcass, 1-day adult  (42) carcass, 4-day adult    11 carcass, 20-day adult    6 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    3 accessory gland, mated 4-day male    2 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering  (163) central nervous system, larvae L3    33 central nervous system, pupae P8  109 head, virgin 1-day female    74 head, virgin 4-day female    6 head, virgin 20-day female    6 head, mated 1-day female    28 head, mated 4-day female    3 head, mated 20-day female    4 head, mated 1-day male    54 head, mated 4-day male    6 head, mated 20-day male    7 salivary gland, larvae L3 wandering    2 salivary gland, white prepupae    22 digestive system, larvae L3 wandering    20 digestive system, 1-day adult    3 digestive system, 4-day adult    3 digestive system, 20-day adult    1 fat body, larvae L3 wandering    5 fat body, white prepupae    29 fat body, pupae P8  (222) carcass, larvae L3 wandering  134 carcass, 1-day adult    42 carcass, 4-day adult    11 carcass, 20-day adult    6 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    3 accessory gland, mated 4-day male    2 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    163 central nervous system, larvae L3    33 central nervous system, pupae P8    109 head, virgin 1-day female    74 head, virgin 4-day female    6 head, virgin 20-day female    6 head, mated 1-day female    28 head, mated 4-day female    3 head, mated 20-day female    4 head, mated 1-day male    54 head, mated 4-day male    6 head, mated 20-day male    7 salivary gland, larvae L3 wandering    2 salivary gland, white prepupae    22 digestive system, larvae L3 wandering    20 digestive system, 1-day adult    3 digestive system, 4-day adult    3 digestive system, 20-day adult    1 fat body, larvae L3 wandering    5 fat body, white prepupae    29 fat body, pupae P8    222 carcass, larvae L3 wandering    134 carcass, 1-day adult    42 carcass, 4-day adult    11 carcass, 20-day adult    6 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    3 accessory gland, mated 4-day male    2 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Tissue   Expression Level imaginal disc, larvae L3 wandering     central nervous system, larvae L3     central nervous system, pupae P8     head, virgin 1-day female     head, virgin 4-day female     head, virgin 20-day female     head, mated 1-day female     head, mated 4-day female     head, mated 20-day female     head, mated 1-day male     head, mated 4-day male     head, mated 20-day male     salivary gland, larvae L3 wandering     salivary gland, white prepupae     digestive system, larvae L3 wandering     digestive system, 1-day adult     digestive system, 4-day adult     digestive system, 20-day adult     fat body, larvae L3 wandering     fat body, white prepupae     fat body, pupae P8     carcass, larvae L3 wandering     carcass, 1-day adult     carcass, 4-day adult     carcass, 20-day adult     ovary, virgin 4-day female     ovary, mated 4-day female     testis, mated 4-day male     accessory gland, mated 4-day male
modENCODE Development RNA-Seq
modENCODE Temporal Expression Data (modENCODE_mRNA-Seq_U)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of very high expression to a trough of low expression. Peak expression observed within 06-24 hour embryonic stages, at stages throughout the larval period, at stages throughout the pupal period. [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    5 embryo 02-04hr    5 embryo 04-06hr    4 embryo 06-08hr    38 embryo 08-10hr    85 embryo 10-12hr    388 embryo 12-14hr    381 embryo 14-16hr    1178 embryo 16-18hr    1215 embryo 18-20hr    1190 embryo 20-22hr    215 embryo 22-24hr    199 larva L1    314 larva L2    557 larva L3 12hr old    775 larva L3 puffstage 1-2    187 larva L3 puffstage 3-6    115 larva L3 puffstage 7-9    124 white prepupae new    221 white prepupae 12hr    663 white prepupae 24hr    121 pupae 2d postWPP    373 pupae 3d postWPP    375 pupae 4d postWPP    273 adult male 01day    110 adult male 05day    11 adult male 30day    12 adult female 01day    93 adult female 05day    3 adult female 30day    2 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    5 embryo 02-04hr    5 embryo 04-06hr    4 embryo 06-08hr  (38) embryo 08-10hr  (85) embryo 10-12hr  (388) embryo 12-14hr  (381) embryo 14-16hr  (1178) embryo 16-18hr  (1215) embryo 18-20hr  (1190) embryo 20-22hr  (215) embryo 22-24hr  (199) larva L1  (314) larva L2  (557) larva L3 12hr old  (775) larva L3 puffstage 1-2  (187) larva L3 puffstage 3-6  (115) larva L3 puffstage 7-9  (124) white prepupae new  (221) white prepupae 12hr  (663) white prepupae 24hr  (121) pupae 2d postWPP  (373) pupae 3d postWPP  (375) pupae 4d postWPP  (273) adult male 01day  (110) adult male 05day    11 adult male 30day    12 adult female 01day  (93) adult female 05day    3 adult female 30day    2 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    5 embryo 02-04hr    5 embryo 04-06hr    4 embryo 06-08hr    38 embryo 08-10hr    85 embryo 10-12hr  (388) embryo 12-14hr  (381) embryo 14-16hr  (1178) embryo 16-18hr  (1215) embryo 18-20hr  (1190) embryo 20-22hr  (215) embryo 22-24hr  (199) larva L1  (314) larva L2  (557) larva L3 12hr old  (775) larva L3 puffstage 1-2  (187) larva L3 puffstage 3-6  (115) larva L3 puffstage 7-9  (124) white prepupae new  (221) white prepupae 12hr  (663) white prepupae 24hr  (121) pupae 2d postWPP  (373) pupae 3d postWPP  (375) pupae 4d postWPP  (273) adult male 01day  (110) adult male 05day    11 adult male 30day    12 adult female 01day    93 adult female 05day    3 adult female 30day    2 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    5 embryo 02-04hr    5 embryo 04-06hr    4 embryo 06-08hr    38 embryo 08-10hr    85 embryo 10-12hr    388 embryo 12-14hr    381 embryo 14-16hr    1178 embryo 16-18hr    1215 embryo 18-20hr    1190 embryo 20-22hr    215 embryo 22-24hr    199 larva L1    314 larva L2    557 larva L3 12hr old    775 larva L3 puffstage 1-2    187 larva L3 puffstage 3-6    115 larva L3 puffstage 7-9    124 white prepupae new    221 white prepupae 12hr    663 white prepupae 24hr    121 pupae 2d postWPP    373 pupae 3d postWPP    375 pupae 4d postWPP    273 adult male 01day    110 adult male 05day    11 adult male 30day    12 adult female 01day    93 adult female 05day    3 adult female 30day    2 Expression Level Scale  Extremely high  log, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    5 embryo 02-04hr    5 embryo 04-06hr    4 embryo 06-08hr    38 embryo 08-10hr    85 embryo 10-12hr    388 embryo 12-14hr    381 embryo 14-16hr    1178 embryo 16-18hr    1215 embryo 18-20hr    1190 embryo 20-22hr    215 embryo 22-24hr    199 larva L1    314 larva L2    557 larva L3 12hr old    775 larva L3 puffstage 1-2    187 larva L3 puffstage 3-6    115 larva L3 puffstage 7-9    124 white prepupae new    221 white prepupae 12hr    663 white prepupae 24hr    121 pupae 2d postWPP    373 pupae 3d postWPP    375 pupae 4d postWPP    273 adult male 01day    110 adult male 05day    11 adult male 30day    12 adult female 01day    93 adult female 05day    3 adult female 30day    2 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    5 embryo 02-04hr    5 embryo 04-06hr    4 embryo 06-08hr  (38) embryo 08-10hr  (85) embryo 10-12hr  (388) embryo 12-14hr  (381) embryo 14-16hr  (1178) embryo 16-18hr  (1215) embryo 18-20hr  (1190) embryo 20-22hr  (215) embryo 22-24hr  (199) larva L1  (314) larva L2  (557) larva L3 12hr old  (775) larva L3 puffstage 1-2  (187) larva L3 puffstage 3-6  (115) larva L3 puffstage 7-9  (124) white prepupae new  (221) white prepupae 12hr  (663) white prepupae 24hr  (121) pupae 2d postWPP  (373) pupae 3d postWPP  (375) pupae 4d postWPP  (273) adult male 01day  (110) adult male 05day    11 adult male 30day    12 adult female 01day  (93) adult female 05day    3 adult female 30day    2 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    5 embryo 02-04hr    5 embryo 04-06hr    4 embryo 06-08hr    38 embryo 08-10hr    85 embryo 10-12hr  (388) embryo 12-14hr  (381) embryo 14-16hr  (1178) embryo 16-18hr  (1215) embryo 18-20hr  (1190) embryo 20-22hr  (215) embryo 22-24hr  (199) larva L1  (314) larva L2  (557) larva L3 12hr old  (775) larva L3 puffstage 1-2  (187) larva L3 puffstage 3-6  115 larva L3 puffstage 7-9  124 white prepupae new  (221) white prepupae 12hr  (663) white prepupae 24hr  121 pupae 2d postWPP  (373) pupae 3d postWPP  (375) pupae 4d postWPP  (273) adult male 01day  110 adult male 05day    11 adult male 30day    12 adult female 01day    93 adult female 05day    3 adult female 30day    2 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    5 embryo 02-04hr    5 embryo 04-06hr    4 embryo 06-08hr    38 embryo 08-10hr    85 embryo 10-12hr    388 embryo 12-14hr    381 embryo 14-16hr    1178 embryo 16-18hr    1215 embryo 18-20hr    1190 embryo 20-22hr    215 embryo 22-24hr    199 larva L1    314 larva L2    557 larva L3 12hr old    775 larva L3 puffstage 1-2    187 larva L3 puffstage 3-6    115 larva L3 puffstage 7-9    124 white prepupae new    221 white prepupae 12hr    663 white prepupae 24hr    121 pupae 2d postWPP    373 pupae 3d postWPP    375 pupae 4d postWPP    273 adult male 01day    110 adult male 05day    11 adult male 30day    12 adult female 01day    93 adult female 05day    3 adult female 30day    2 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     modENCODE Temporal Expression Data (Graveley et al., 2011)
modENCODE Cell Lines RNA-Seq
modENCODE Cell Line Expression Data (modENCODE_mRNA-Seq_cell.A) (modENCODE_mRNA-Seq_cell.B)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    0 Schneider line 2 Sg4    0 embryonic 1182-4H    0 embryonic GM2    0 embryonic Kc167    0 embryonic S1    0 embryonic S3    0 leg disc CME L1    0 wing disc CME-W2    0 wing disc ML-DmD8    0 wing disc ML-DmD9    0 wing disc ML-DmD16-c3    0 wing disc ML-DmD21    0 wing disc ML-DmD32    0 haltere disc ML-DmD17-c3    0 eye-antennal disc ML-DmD11    0 antennal disc ML-DmD20-c5    0 mixed discs ML-DmD4-c1    0 CNS ML-DmBG1-c1    0 CNS ML-DmBG2-c2    1 tumorous blood cells mbn2    0 ovary fGS/OSS    1 ovary OSC    0 ovary OSS    2 Expression Level Scale  Very low   Low   Moderate  Linear, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+    0 Schneider line 2 Sg4    0 embryonic 1182-4H    0 embryonic GM2    0 embryonic Kc167    0 embryonic S1    0 embryonic S3    0 leg disc CME L1    0 wing disc CME-W2    0 wing disc ML-DmD8    0 wing disc ML-DmD9    0 wing disc ML-DmD16-c3    0 wing disc ML-DmD21    0 wing disc ML-DmD32    0 haltere disc ML-DmD17-c3    0 eye-antennal disc ML-DmD11    0 antennal disc ML-DmD20-c5    0 mixed discs ML-DmD4-c1    0 CNS ML-DmBG1-c1    0 CNS ML-DmBG2-c2    1 tumorous blood cells mbn2    0 ovary fGS/OSS    1 ovary OSC    0 ovary OSS    2 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    0 Schneider line 2 Sg4    0 embryonic 1182-4H    0 embryonic GM2    0 embryonic Kc167    0 embryonic S1    0 embryonic S3    0 leg disc CME L1    0 wing disc CME-W2    0 wing disc ML-DmD8    0 wing disc ML-DmD9    0 wing disc ML-DmD16-c3    0 wing disc ML-DmD21    0 wing disc ML-DmD32    0 haltere disc ML-DmD17-c3    0 eye-antennal disc ML-DmD11    0 antennal disc ML-DmD20-c5    0 mixed discs ML-DmD4-c1    0 CNS ML-DmBG1-c1    0 CNS ML-DmBG2-c2    1 tumorous blood cells mbn2    0 ovary fGS/OSS    1 ovary OSC    0 ovary OSS    2 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    0 Schneider line 2 Sg4    0 embryonic 1182-4H    0 embryonic GM2    0 embryonic Kc167    0 embryonic S1    0 embryonic S3    0 leg disc CME L1    0 wing disc CME-W2    0 wing disc ML-DmD8    0 wing disc ML-DmD9    0 wing disc ML-DmD16-c3    0 wing disc ML-DmD21    0 wing disc ML-DmD32    0 haltere disc ML-DmD17-c3    0 eye-antennal disc ML-DmD11    0 antennal disc ML-DmD20-c5    0 mixed discs ML-DmD4-c1    0 CNS ML-DmBG1-c1    0 CNS ML-DmBG2-c2    1 tumorous blood cells mbn2    0 ovary fGS/OSS    1 ovary OSC    0 ovary OSS    2 Expression Level Scale  Extremely high  log, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    0 Schneider line 2 Sg4    0 embryonic 1182-4H    0 embryonic GM2    0 embryonic Kc167    0 embryonic S1    0 embryonic S3    0 leg disc CME L1    0 wing disc CME-W2    0 wing disc ML-DmD8    0 wing disc ML-DmD9    0 wing disc ML-DmD16-c3    0 wing disc ML-DmD21    0 wing disc ML-DmD32    0 haltere disc ML-DmD17-c3    0 eye-antennal disc ML-DmD11    0 antennal disc ML-DmD20-c5    0 mixed discs ML-DmD4-c1    0 CNS ML-DmBG1-c1    0 CNS ML-DmBG2-c2    1 tumorous blood cells mbn2    0 ovary fGS/OSS    1 ovary OSC    0 ovary OSS    2 Expression Level Scale  Very low   Low   Moderate  log, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+    0 Schneider line 2 Sg4    0 embryonic 1182-4H    0 embryonic GM2    0 embryonic Kc167    0 embryonic S1    0 embryonic S3    0 leg disc CME L1    0 wing disc CME-W2    0 wing disc ML-DmD8    0 wing disc ML-DmD9    0 wing disc ML-DmD16-c3    0 wing disc ML-DmD21    0 wing disc ML-DmD32    0 haltere disc ML-DmD17-c3    0 eye-antennal disc ML-DmD11    0 antennal disc ML-DmD20-c5    0 mixed discs ML-DmD4-c1    0 CNS ML-DmBG1-c1    0 CNS ML-DmBG2-c2    1 tumorous blood cells mbn2    0 ovary fGS/OSS    1 ovary OSC    0 ovary OSS    2 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    0 Schneider line 2 Sg4    0 embryonic 1182-4H    0 embryonic GM2    0 embryonic Kc167    0 embryonic S1    0 embryonic S3    0 leg disc CME L1    0 wing disc CME-W2    0 wing disc ML-DmD8    0 wing disc ML-DmD9    0 wing disc ML-DmD16-c3    0 wing disc ML-DmD21    0 wing disc ML-DmD32    0 haltere disc ML-DmD17-c3    0 eye-antennal disc ML-DmD11    0 antennal disc ML-DmD20-c5    0 mixed discs ML-DmD4-c1    0 CNS ML-DmBG1-c1    0 CNS ML-DmBG2-c2    1 tumorous blood cells mbn2    0 ovary fGS/OSS    1 ovary OSC    0 ovary OSS    2 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    0 Schneider line 2 Sg4    0 embryonic 1182-4H    0 embryonic GM2    0 embryonic Kc167    0 embryonic S1    0 embryonic S3    0 leg disc CME L1    0 wing disc CME-W2    0 wing disc ML-DmD8    0 wing disc ML-DmD9    0 wing disc ML-DmD16-c3    0 wing disc ML-DmD21    0 wing disc ML-DmD32    0 haltere disc ML-DmD17-c3    0 eye-antennal disc ML-DmD11    0 antennal disc ML-DmD20-c5    0 mixed discs ML-DmD4-c1    0 CNS ML-DmBG1-c1    0 CNS ML-DmBG2-c2    1 tumorous blood cells mbn2    0 ovary fGS/OSS    1 ovary OSC    0 ovary OSS    2 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Cell Line   Expression Level Schneider line 2 S2R+     Schneider line 2 Sg4     embryonic 1182-4H     embryonic GM2     embryonic Kc167     embryonic S1     embryonic S3     leg disc CME L1     wing disc CME-W2     wing disc ML-DmD8     wing disc ML-DmD9     wing disc ML-DmD16-c3     wing disc ML-DmD21     wing disc ML-DmD32     haltere disc ML-DmD17-c3     eye-antennal disc ML-DmD11     antennal disc ML-DmD20-c5     mixed discs ML-DmD4-c1     CNS ML-DmBG1-c1     CNS ML-DmBG2-c2     tumorous blood cells mbn2     ovary fGS/OSS     ovary OSC     ovary OSS
modENCODE Treatments RNA-Seq
modENCODE Treatment Expression Data (modENCODE_mRNA-Seq_treatments)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    22 cold shock, 4-day adult    22 heat shock, 4-day adult    129 Cadmium 50 mM 6 hrs, larvae L3    260 Cadmium 50 mM 12 hrs, larvae L3    100 Cadmium 50 mM 48 hrs, 4-day adult    171 Cadmium 100 mM 48 hrs, 4-day adult    8 Copper 0.5 mM 12 hrs, larvae L3    169 Copper 15 mM 48 hrs, 4-day adult    7 Zinc 5 mM 12 hrs, larvae L3    139 Zinc 4.5 mM 48 hrs, 4-day adult    17 Ethanol 2.5% 3 hrs, larvae L3    6 Ethanol 5% 3 hrs, larvae L3    154 Ethanol 10% 3 hrs, larvae L3    234 Caffeine 1.5 mg/ml 4 hrs, larvae L3    95 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    5 Caffeine 25 mg/ml 48 hrs, 4-day adult    23 Paraquat 5 mM 48 hrs, 4-day adult    9 Paraquat 10 mM 48 hrs, 4-day adult    17 Rotenone 2 μg 12 hrs, larvae L3    203 Rotenone 8 μg 12 hrs, larvae L3    283 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult    22 cold shock, 4-day adult    22 heat shock, 4-day adult  (129) Cadmium 50 mM 6 hrs, larvae L3  (260) Cadmium 50 mM 12 hrs, larvae L3  (100) Cadmium 50 mM 48 hrs, 4-day adult  (171) Cadmium 100 mM 48 hrs, 4-day adult    8 Copper 0.5 mM 12 hrs, larvae L3  (169) Copper 15 mM 48 hrs, 4-day adult    7 Zinc 5 mM 12 hrs, larvae L3  (139) Zinc 4.5 mM 48 hrs, 4-day adult    17 Ethanol 2.5% 3 hrs, larvae L3    6 Ethanol 5% 3 hrs, larvae L3  (154) Ethanol 10% 3 hrs, larvae L3  (234) Caffeine 1.5 mg/ml 4 hrs, larvae L3  (95) Caffeine 2.5 mg/ml 48 hrs, 4-day adult    5 Caffeine 25 mg/ml 48 hrs, 4-day adult    23 Paraquat 5 mM 48 hrs, 4-day adult    9 Paraquat 10 mM 48 hrs, 4-day adult    17 Rotenone 2 μg 12 hrs, larvae L3  (203) Rotenone 8 μg 12 hrs, larvae L3  (283) Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    22 cold shock, 4-day adult    22 heat shock, 4-day adult  (129) Cadmium 50 mM 6 hrs, larvae L3  (260) Cadmium 50 mM 12 hrs, larvae L3    100 Cadmium 50 mM 48 hrs, 4-day adult  (171) Cadmium 100 mM 48 hrs, 4-day adult    8 Copper 0.5 mM 12 hrs, larvae L3  (169) Copper 15 mM 48 hrs, 4-day adult    7 Zinc 5 mM 12 hrs, larvae L3  (139) Zinc 4.5 mM 48 hrs, 4-day adult    17 Ethanol 2.5% 3 hrs, larvae L3    6 Ethanol 5% 3 hrs, larvae L3  (154) Ethanol 10% 3 hrs, larvae L3  (234) Caffeine 1.5 mg/ml 4 hrs, larvae L3    95 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    5 Caffeine 25 mg/ml 48 hrs, 4-day adult    23 Paraquat 5 mM 48 hrs, 4-day adult    9 Paraquat 10 mM 48 hrs, 4-day adult    17 Rotenone 2 μg 12 hrs, larvae L3  (203) Rotenone 8 μg 12 hrs, larvae L3  (283) Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    22 cold shock, 4-day adult    22 heat shock, 4-day adult    129 Cadmium 50 mM 6 hrs, larvae L3    260 Cadmium 50 mM 12 hrs, larvae L3    100 Cadmium 50 mM 48 hrs, 4-day adult    171 Cadmium 100 mM 48 hrs, 4-day adult    8 Copper 0.5 mM 12 hrs, larvae L3    169 Copper 15 mM 48 hrs, 4-day adult    7 Zinc 5 mM 12 hrs, larvae L3    139 Zinc 4.5 mM 48 hrs, 4-day adult    17 Ethanol 2.5% 3 hrs, larvae L3    6 Ethanol 5% 3 hrs, larvae L3    154 Ethanol 10% 3 hrs, larvae L3    234 Caffeine 1.5 mg/ml 4 hrs, larvae L3    95 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    5 Caffeine 25 mg/ml 48 hrs, 4-day adult    23 Paraquat 5 mM 48 hrs, 4-day adult    9 Paraquat 10 mM 48 hrs, 4-day adult    17 Rotenone 2 μg 12 hrs, larvae L3    203 Rotenone 8 μg 12 hrs, larvae L3    283 Expression Level Scale  Extremely high  log, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    22 cold shock, 4-day adult    22 heat shock, 4-day adult    129 Cadmium 50 mM 6 hrs, larvae L3    260 Cadmium 50 mM 12 hrs, larvae L3    100 Cadmium 50 mM 48 hrs, 4-day adult    171 Cadmium 100 mM 48 hrs, 4-day adult    8 Copper 0.5 mM 12 hrs, larvae L3    169 Copper 15 mM 48 hrs, 4-day adult    7 Zinc 5 mM 12 hrs, larvae L3    139 Zinc 4.5 mM 48 hrs, 4-day adult    17 Ethanol 2.5% 3 hrs, larvae L3    6 Ethanol 5% 3 hrs, larvae L3    154 Ethanol 10% 3 hrs, larvae L3    234 Caffeine 1.5 mg/ml 4 hrs, larvae L3    95 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    5 Caffeine 25 mg/ml 48 hrs, 4-day adult    23 Paraquat 5 mM 48 hrs, 4-day adult    9 Paraquat 10 mM 48 hrs, 4-day adult    17 Rotenone 2 μg 12 hrs, larvae L3    203 Rotenone 8 μg 12 hrs, larvae L3    283 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult    22 cold shock, 4-day adult    22 heat shock, 4-day adult  (129) Cadmium 50 mM 6 hrs, larvae L3  (260) Cadmium 50 mM 12 hrs, larvae L3  (100) Cadmium 50 mM 48 hrs, 4-day adult  (171) Cadmium 100 mM 48 hrs, 4-day adult    8 Copper 0.5 mM 12 hrs, larvae L3  (169) Copper 15 mM 48 hrs, 4-day adult    7 Zinc 5 mM 12 hrs, larvae L3  (139) Zinc 4.5 mM 48 hrs, 4-day adult    17 Ethanol 2.5% 3 hrs, larvae L3    6 Ethanol 5% 3 hrs, larvae L3  (154) Ethanol 10% 3 hrs, larvae L3  (234) Caffeine 1.5 mg/ml 4 hrs, larvae L3  (95) Caffeine 2.5 mg/ml 48 hrs, 4-day adult    5 Caffeine 25 mg/ml 48 hrs, 4-day adult    23 Paraquat 5 mM 48 hrs, 4-day adult    9 Paraquat 10 mM 48 hrs, 4-day adult    17 Rotenone 2 μg 12 hrs, larvae L3  (203) Rotenone 8 μg 12 hrs, larvae L3  (283) Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    22 cold shock, 4-day adult    22 heat shock, 4-day adult  129 Cadmium 50 mM 6 hrs, larvae L3  (260) Cadmium 50 mM 12 hrs, larvae L3    100 Cadmium 50 mM 48 hrs, 4-day adult  (171) Cadmium 100 mM 48 hrs, 4-day adult    8 Copper 0.5 mM 12 hrs, larvae L3  (169) Copper 15 mM 48 hrs, 4-day adult    7 Zinc 5 mM 12 hrs, larvae L3  139 Zinc 4.5 mM 48 hrs, 4-day adult    17 Ethanol 2.5% 3 hrs, larvae L3    6 Ethanol 5% 3 hrs, larvae L3  (154) Ethanol 10% 3 hrs, larvae L3  (234) Caffeine 1.5 mg/ml 4 hrs, larvae L3    95 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    5 Caffeine 25 mg/ml 48 hrs, 4-day adult    23 Paraquat 5 mM 48 hrs, 4-day adult    9 Paraquat 10 mM 48 hrs, 4-day adult    17 Rotenone 2 μg 12 hrs, larvae L3  (203) Rotenone 8 μg 12 hrs, larvae L3  (283) Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    22 cold shock, 4-day adult    22 heat shock, 4-day adult    129 Cadmium 50 mM 6 hrs, larvae L3    260 Cadmium 50 mM 12 hrs, larvae L3    100 Cadmium 50 mM 48 hrs, 4-day adult    171 Cadmium 100 mM 48 hrs, 4-day adult    8 Copper 0.5 mM 12 hrs, larvae L3    169 Copper 15 mM 48 hrs, 4-day adult    7 Zinc 5 mM 12 hrs, larvae L3    139 Zinc 4.5 mM 48 hrs, 4-day adult    17 Ethanol 2.5% 3 hrs, larvae L3    6 Ethanol 5% 3 hrs, larvae L3    154 Ethanol 10% 3 hrs, larvae L3    234 Caffeine 1.5 mg/ml 4 hrs, larvae L3    95 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    5 Caffeine 25 mg/ml 48 hrs, 4-day adult    23 Paraquat 5 mM 48 hrs, 4-day adult    9 Paraquat 10 mM 48 hrs, 4-day adult    17 Rotenone 2 μg 12 hrs, larvae L3    203 Rotenone 8 μg 12 hrs, larvae L3    283 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Treatment   Expression Level extended cold, 4-day adult     cold shock, 4-day adult     heat shock, 4-day adult     Cadmium 50 mM 6 hrs, larvae L3     Cadmium 50 mM 12 hrs, larvae L3     Cadmium 50 mM 48 hrs, 4-day adult     Cadmium 100 mM 48 hrs, 4-day adult     Copper 0.5 mM 12 hrs, larvae L3     Copper 15 mM 48 hrs, 4-day adult     Zinc 5 mM 12 hrs, larvae L3     Zinc 4.5 mM 48 hrs, 4-day adult     Ethanol 2.5% 3 hrs, larvae L3     Ethanol 5% 3 hrs, larvae L3     Ethanol 10% 3 hrs, larvae L3     Caffeine 1.5 mg/ml 4 hrs, larvae L3     Caffeine 2.5 mg/ml 48 hrs, 4-day adult     Caffeine 25 mg/ml 48 hrs, 4-day adult     Paraquat 5 mM 48 hrs, 4-day adult     Paraquat 10 mM 48 hrs, 4-day adult     Rotenone 2 μg 12 hrs, larvae L3     Rotenone 8 μg 12 hrs, larvae L3
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (Graveley et al., 2011) mE1_20_mRNA_expression_cluster_10
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0261341
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele lethal | embryonic stage vermKG07819 lethal | pupal stage, with Scer\GAL4pnr-MD237 vermGD6045 vermGD16311 Other Phenotypes Allele visual behavior defective | adult stage | heat sensitive verma.hs.PM Phenotype manifest in Allele cuticle vermKG07819 cuticle | embryonic stage 16 vermKG07819 dorsal trunk primordium | heat sensitive verma.hs.PM embryonic/first instar larval cuticle vermKG07819 embryonic/larval dorsal trunk vermKG07819 embryonic/larval dorsal trunk | embryonic stage 16 vermKG07819 embryonic/larval trachea vermKG07819 embryonic/larval tracheal system vermKG07819 embryonic/larval tracheal system, with Scer\GAL4btl.PS vermScer\UAS.D vermScer\UAS.T:Avic\GFP-EGFP tracheal branch primordium | heat sensitive verma.hs.PM
Classical Alleles ( 3 )
For All Classical Alleles Show
Allele of verm Class Mutagen Stocks Known lesion verm76BDx-6 1 -- vermKG07819 loss of function allele P-element activity 1 Yes vermex7 0 Yes
Alleles Carried on Transgenic Constructs ( 9 )
For All Alleles Carried on Transgenic Constructs Show
Allele of verm Class Mutagen Stocks Known lesion vermGD6045 in vitro construct - RNAi in vitro construct - regulatory fusion 2 Yes vermGD16311 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes verma.hs.PM in vitro construct - regulatory fusion 0 Yes vermhs.PM in vitro construct - regulatory fusion 0 Yes vermKK111195 in vitro construct - RNAi in vitro construct - regulatory fusion 0 Yes vermNIG.8756R in vitro construct - RNAi in vitro construct - regulatory fusion 0 Yes vermScer\UAS.D 0 Yes vermScer\UAS.T:Avic\GFP-EGFP in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes vermScer\UAS.T:Disc\RFP-mRFP in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes
Aneuploid Aberrations
Not disrupted in	Df(3L)25-21 (Cooper et al., 2010) Df(3L)BSC2 (Cooper et al., 2010) Df(3L)BSC20 (Cooper et al., 2010) Df(3L)BSC417 (Cooper et al., 2010) Df(3L)BSC445 (Cooper et al., 2010) Df(3L)ED4799 (Cooper et al., 2010) Df(3L)ED4858 (Cooper et al., 2010) Df(3L)Exel9011 (Cooper et al., 2010) Df(3L)Exel9045 (Cooper et al., 2010) Df(3L)Exel9046 (Cooper et al., 2010) Df(3L)kto22 (Cooper et al., 2010) Df(3L)pipeA13 (Cooper et al., 2010) Df(3L)XS411 (Cooper et al., 2010)
Disrupted in	Df(3L)A23 (Cooper et al., 2010) Df(3L)ash1A16 (Cooper et al., 2010) Df(3L)ED228 (Cooper et al., 2010) Df(3L)Exel6135 (Ryder, 2004.4.26, Luschnig et al., 2006, Cooper et al., 2010) Df(3L)Exel9007 (Cooper et al., 2010) Df(3L)Exel9008 (Cooper et al., 2010) Df(3L)Exel9009 (Cooper et al., 2010) Df(3L)kto2 (Cook, 2008.12.1, Cooper et al., 2010) Df(3L)XS533 (Cooper et al., 2010) Df(3L)XS543 (Cooper et al., 2010) Df(3L)XS572 (Cooper et al., 2010) Df(3L)XS705 (Cooper et al., 2010) Df(3L)XS917 (Cooper et al., 2010) Df(3L)XS2182 (Cooper et al., 2010)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{KK111195} NA P{NIG.8756R} NA P{UAS-verm.RFP} NA
Insertions
	Type of insertions Name Expression data miscellaneous insertions P{SUPor-P}vermKG07819 NA
Gene Ontology: Function, Process & Cellular Component ( 11 unique terms )
Terms Based on Experimental Evidence ( 7 terms )
Molecular Function
CV term Evidence References
chitin binding inferred from mutant phenotype (Luschnig et al., 2006) chitin deacetylase activity inferred from mutant phenotype (Luschnig et al., 2006)
Biological Process
CV term Evidence References
dorsal trunk growth, open tracheal system inferred from mutant phenotype (McKay et al., 2008) open tracheal system development inferred from mutant phenotype (Luschnig et al., 2006, Wang et al., 2006) regulation of tube length, open tracheal system inferred from mutant phenotype (Luschnig et al., 2006, Wang et al., 2006) trachea morphogenesis inferred from mutant phenotype (McKay et al., 2008) visual behavior inferred from mutant phenotype (McKay et al., 2008)
Cellular Component ( 0 terms)
Terms Based on Predictions or Assertions ( 4 terms )
Molecular Function
CV term Evidence References
low-density lipoprotein receptor activity inferred from sequence or structural similarity (McKay et al., 1996)
Biological Process
CV term Evidence References
carbohydrate metabolic process inferred from electronic annotation with InterPro:IPR002509, InterPro:IPR011330 (FlyBase Curators et al., 2004-) chitin metabolic process inferred from electronic annotation with InterPro:IPR002557 (FlyBase Curators et al., 2004-)
Cellular Component
CV term Evidence References
extracellular region inferred from electronic annotation with InterPro:IPR002557 (FlyBase Curators et al., 2004-)
Sequence Ontology: Class of Gene
	gene   nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
protein-protein
Interacting group Assay References
verm - CG11107 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) verm - Cdc5 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) verm - Imp anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) verm - Pdi anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) verm - Rsf1 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) verm - Ugt anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) verm - Wbp2 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) verm - prtp anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) verm - yrt anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23)
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions verm allele Gene References
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 65419 DPiM - DPiM, Drosophila Protein interaction Map • FBgn0261341 DroID - A comprehensive database of gene and protein interactions. • FBgn0261341 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 40149
Orthologs
OrthoDB Orthologs (35) - based on analysis using Dmel annotation version 5.41
OrthoDB Ortholog Groups
	OrthoDB orthology group searches (Waterhouse et al., 2011, Nucleic Acids Res. 39(Database issue): D283--D288) Drosophila inclusive ortholog search EOG605SKM Dipteran inclusive ortholog search EOG6V43GV Insect inclusive ortholog search EOG6280WS Arthropod inclusive ortholog search EOG6ZW3S7 Metazoa inclusive ortholog search EOG66XB20
Orthologs in Drosophila Species (EOG605SKM)
Organism Common Name Gene AAA Syntenic Ortholog Multiple Dmel Genes in this Orthologous Group Drosophila melanogaster fruit fly  Dmel\verm     Drosophila simulans   Dsim\GD12256 Y   Drosophila sechellia   Dsec\GM16731     Drosophila erecta   Dere\GG13378 Y   Drosophila yakuba   Dyak\GE22471     Drosophila yakuba   Dyak\GE22474     Drosophila yakuba   Dyak\GE22472 Y   Drosophila ananassae   Dana\GF10716 Y   Drosophila pseudoobscura pseudoobscura   Dpse\GA21299 Y   Drosophila persimilis   Dper\GL20872     Drosophila willistoni   Dwil\GK25749 Y   Drosophila virilis   Dvir\GJ11863 Y   Drosophila mojavensis   Dmoj\GI13502 Y   Drosophila grimshawi   Dgri\GH14614 Y
Orthologs in non-Drosophila Dipterans (EOG6V43GV)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Aedes aegypti Yellow fever mosquito  Aaeg\AAEL003425   Anopheles gambiae Malaria mosquito  Agam\AGAP011937   Culex quinquefasciatus Southern house mosquito  Cqui\CPIJ008266
Orthologs in non-Dipteran Insects (EOG6280WS)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Apis mellifera Western honey bee  Amel\verm   Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG014030   Acromyrmex echinatior Panamanian leafcutter ant  Aech\AECH19072   Atta cephalotes Leafcutter ant  Acep\ACEP21691   Camponotus floridanus Florida carpenter ant  Cflo\CFLO22557   Harpegnathos saltator Jerdons jumping ant  Hsal\HSAL19734   Linepithema humile Argentine ant  Lhum\LH24439   Pogonomyrmex barbatus Red harvester ant  Pbar\PB19814   Solenopsis invicta Red fire ant  Sinv\SINV22645   Acyrthosiphon pisum Pea aphid  Apim\ACYPI000227   Acyrthosiphon pisum Pea aphid  Apim\ACYPI088287   Bombyx mori Silkmoth  Bmor\BGIBMGA006214   Pediculus humanus Human body louse  Phum\PHUM148860   Tribolium castaneum Red flour beetle  Tcas\TC014101
Orthologs in non-Insect Arthropods (EOG6ZW3S7)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Daphnia pulex Water flea  Dpux\COI Y Daphnia pulex Water flea  Dpux\JGI_V11_309273 Y Ixodes scapularis Deer tick  Isca\ISCW013286 Y
Orthologs in non-Arthropod Metazoa (EOG66XB20)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Caenorhabditis elegans Nematode  Cele\C54G7.3 Y
Human Orthologs (0)
Gene OMIM HGNC
AAA Orthologs (9) based on analysis using Dmel annotation version 4.3
Organism Gene Drosophila simulans Dsim\GD12256 Drosophila erecta Dere\GG13378 Drosophila yakuba Dyak\GE22472 Drosophila ananassae Dana\GF10716 Drosophila pseudoobscura pseudoobscura Dpse\GA21299 Drosophila willistoni Dwil\GK25749 Drosophila virilis Dvir\GJ11863 Drosophila mojavensis Dmoj\GI13502 Drosophila grimshawi Dgri\GH14614
Stocks & Reagents
Stocks Listed in FlyBase ( 5 )
Bloomington	14660 y1; P{SUPor-P}vermKG07819 ry506/TM3, Sb1 Ser1 26177 verm76BDx-6 red1 e4/TM6B, Sb1 Tb1 ca1
VDRC	v15464 w1118; P{GD6045}v15464 v15465 w1118; P{GD6045}v15465 v47128 w1118; P{GD16311}v47128
Genomic Clones ( 1 )
	BACR23N10 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 129 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	GH05968 LD36620 LP01646 LP14866 LP19581 RH70707
Other clones	DPiM_LD36620
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	AT16064 AT16170 AT19763 GH09321 HL01656 LD25884 LD38123 LP02669 LP03233 LP03352 LP03484 LP03643 LP06254 LP10872 LP11123 LP11540 LP14714 LP15221 LP15794 LP17277 LP17323 LP20275 LP23244 RE04023 RE22170 RE22933 RE23140 RE24431 RE29613 RE32344 RE37356 RE44852 RE45873 RE47583 RE49855 RE54719 RE66705 RE67236 RE67918 RE75076 RH04828 RH05093 RH05865 RH06502 RH08070 RH23762 RH23992 RH24556 RH34573 RH35864 RH36534 RH36540 RH39785 RH44733 RH45467 RH50507 RH54760
Other clones	16085 33086 39879 43248 45786 53463 60575 63262 65246 70047 73489 80077 98284 101701 103383 107670 125645 147876 154714 163248 176594 214413.41 CK01.13D.F7 CK01.36C.H6 CK01.38A.F6 CK01.40A.B12 CK01.49B.H2 CK01.60A.A4 CK01.69B.F9 CK01.109D.E1 CK01.118C.D6 CK01.131B.F5 EK039010 EK041461 EK047326 EK055323 EK063334 EK065417 EK099117 EK143415 EK154029 EK157851 EK158807 EK161839 EK171531 EK192013 EK197539 EK202958 EK212529 EK228612 EK233522 EK243241 EK247635 EK253410 EK257456 EK258245 EK267460 EK279701 EK291214 EP15044 IP14979 IP15079 IP15179 LD24476 RP004089501
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0261341 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 40149
Antibody Information
	polyclonal (McKay et al., 2008)
Other Information
Discoverer
Etymology
	Named "vermiform" based on the tracheal phenotypes of the mutants. (Wang et al., 2006)
Identification
Relationship to Other Genes
Source for database identity of	Source for identity of: LCBP1 CG8756 (Wang et al., 2005) Source for identity of: verm LCBP1 (Wang et al., 2006)
Source for database merge of	Source for merge of: verm hlm (McKay et al., 2008)
Additional comments
Other Comments
	Identification: By virtue of its expression in the fruit fly retina during visual system neural network development. Embryonic expression of anti-sense hlm RNA arrests outgrowth and branching in the developing trachea. Expression of anti-sense hlm RNA during visual system formation results in reduced visual acuity as assayed by the optomotor response, indicative of an abnormal neural network. (Pollock et al., 1998) Identified in a subtractive hybridization screen for genes expressed in the adult nervous system. (McKay and Pollock, 1995)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_168809 NM_001169999 RefSeq (Proteins) • NP_730442 NP_001163470 DDBJ / EMBL / GenBank • AAF49121 AAF49122 AAF49123 AAM49966 AAN11656 AAV36978 ABI95428 ACZ94740 ACZ94741 AI258444 AW943978 AY118597 BH900957 BT016093 DQ665308 Entrez Gene - A searchable database of RefSeq genes. • 40149 UniProtKB/TrEMBL • E1JI40 E1JI41 Q06RG9 Q8IQU1 Q8MSU2 Q9VW30 Q9VW31
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Low-density lipoprotein (LDL) receptor class A, conserved site (IPR023415) Chitin binding domain (IPR002557) Low-density lipoprotein (LDL) receptor class A repeat (IPR002172) Polysaccharide deacetylase (IPR002509) Glycoside hydrolase/deacetylase, beta/alpha-barrel (IPR011330)
Linkouts
	BioGRID - A database of protein and genetic interactions • 65419 DPiM - DPiM, Drosophila Protein interaction Map • FBgn0261341 DroID - A comprehensive database of gene and protein interactions. • FBgn0261341 DRSC - Results from RNAi screens. • FBgn0261341 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0261341 FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0261341 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 40149 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 40149 modMine - Data generated by the modENCODE project. • FBgn0261341
Synonyms & Secondary IDs ( 12 )
Reported As
Symbol Synonym	CG8756 (McKay et al., 2008, Apidianakis et al., 2005, Luschnig et al., 2006, Wang et al., 2006, Lecuyer et al., 2007, Lebo et al., 2009, Keleman et al., 2009.8.5, Cirelli et al., 2005) DmCDA2 (Dixit et al., 2008) hlm (McKay et al., 2008, Pollock et al., 2008) l(3)76BDx (Cook, 2008.12.1, Cooper et al., 2010) LCBP1 (Lebo et al., 2009, Cook, 2008.12.1, Japanese National Institute of Genetics, 2012.5.21) N63 (Pollock, 1998.3.10, McKay et al., 1996, McKay, 1995, McKay and Pollock, 1995, ) verm (Petkau et al., 2012, Wang et al., 2006, Luschnig et al., 2006, Swanson and Beitel, 2006, Araujo et al., 2007, Forster et al., 2010, Chung et al., 2009, Laprise et al., 2010, Cooper et al., 2010, Gangishetti et al., 2012, Ile et al., 2012, Förster and Luschnig, 2012) Verm (Dong et al., 2013, Choi et al., 2011, Swanson et al., 2009, Swanson and Beitel, 2006, Paul et al., 2007, Wu et al., 2007, Tsarouhas et al., 2007, Massarwa et al., 2009, Laplante et al., 2010, Forster et al., 2010, Jayaram et al., 2008, Norum et al., 2010, Nelson et al., 2010, Mariappa et al., 2011, Wang et al., 2012, Armbruster and Luschnig, 2012, Yanagihashi et al., 2012)
Name Synonym	helmsman (Pollock et al., 1998, Pollock et al., 2008, McKay et al., 2008) LDLa domain containing chitin binding protein 1 (Wang et al., 2005) vermiform (Choi et al., 2011, Wang et al., 2006, Luschnig et al., 2006, Araujo et al., 2007, Dixit et al., 2008, Chung et al., 2009, Tiklova et al., 2010, Laprise et al., 2010, Cooper et al., 2010) Vermiform (Swanson and Beitel, 2006, Forster et al., 2010, Norum et al., 2010, Nelson et al., 2010)
Secondary FlyBase IDs
	FBgn0013991 FBgn0036901
References ( 61 )
Generate a list of	All references relating to this gene ( 61 )
List References by type	Research paper  ( 33 ) Supplementary material  ( 6 ) Review  ( 2 ) Personal communication to FlyBase  ( 10 ) Abstract  ( 6 ) FlyBase analysis  ( 1 ) Stock list  ( 1 ) Curated genome annotation  ( 2 )
Recent research papers ( 10 )
	Armbruster and Luschnig, 2012, J. Cell Sci. 125(5): 1318--1328 The Drosophila Sec7 domain guanine nucleotide exchange factor protein Gartenzwerg localizes at the cis-Golgi and is essential for epithelial tube expansion. [FBrf0218010] Förster and Luschnig, 2012, Nat. Cell Biol. 14(5): 526--534 Src42A-dependent polarized cell shape changes mediate epithelial tube elongation in Drosophila. [FBrf0218206] Gangishetti et al., 2012, Insect Mol. Biol. 21(3): 283--295 The transcription factor Grainy head and the steroid hormone ecdysone cooperate during differentiation of the skin of Drosophila melanogaster. [FBrf0218253] Ile et al., 2012, Development 139(14): 2535--2546 Wunen, a Drosophila lipid phosphate phosphatase, is required for septate junction-mediated barrier function. [FBrf0218686] Petkau et al., 2012, J. Biol. Chem. 287(25): 21396--21405 Obstructor-a is required for epithelial extracellular matrix dynamics, exoskeleton function, and tubulogenesis. [FBrf0218765] Wang et al., 2012, J. Cell Sci. 125(2): 461--472 GBF1 (Gartenzwerg)-dependent secretion is required for Drosophila tubulogenesis. [FBrf0217573] Yanagihashi et al., 2012, J. Cell Sci. 125(8): 1980--1990 Snakeskin, a membrane protein associated with smooth septate junctions, is required for intestinal barrier function in Drosophila. [FBrf0218431] Baycin-Hizal et al., 2011, J. Proteome Res. 10(6): 2777--2784 GlycoFly: A Database of Drosophila N-linked Glycoproteins Identified Using SPEG-MS Techniques. [FBrf0213834] Choi et al., 2011, Mol. Biol. Cell 22(12): 2010--2030 The single Drosophila ZO-1 protein Polychaetoid regulates embryonic morphogenesis in coordination with Canoe/afadin and Enabled. [FBrf0213894] Mariappa et al., 2011, Sci. Signal. 4(204): ra89 Protein O-GlcNAcylation Is Required for Fibroblast Growth Factor Signaling in Drosophila. [FBrf0217579] Show all research papers ...
Recent reviews ( 1 )
	Broadie et al., 2011, Dev. Neurobiol. 71(11): 1102--1130 Extracellular matrix and its receptors in drosophila neural development. [FBrf0216377] Show all reviews ...