FB2021_06, released December 14, 2021
Gene: Dmel\CG42637
Gene: Dmel\CG42637
Please see the JBrowse view of Dmel\CG42637 for information on other features
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A large (31.4 kb) polymorphic duplication flanked by Doc elements, contains the coding exons of Gyc76C and CG42637, which are identical in amino acid sequence and share 5' noncoding exons. (see FBrf0211329)
Low-frequency RNA-Seq exon junction(s) not annotated.
Annotated transcripts do not represent all supported alternative splices within 5' UTR.
Gene model reviewed during 5.46
Shares 5' UTR with upstream gene as a result of gene duplication..
Gene model reviewed during 5.48
The group(s) of polypeptides indicated below share identical sequence to each other.
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\CG42637 using the Feature Mapper tool.
GBrowse - Visual display of RNA-Seq signals
View Dmel\CG42637 in GBrowse 23-46
3-43.1
Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
The 76BD region of the iso-1 strain used to sequence the D. melanogaster genome contains a duplication that is flanked by Doc elements. This duplication has not been found in any of the other strains tested (Oregon R, Canton-S and a red1 e4 strain). The presence of the middle Doc element that forms the junction between the two duplicated segments in the annotated genome could not be confirmed in the lab copy of the iso-1 strain. The duplication may thus have arisen after the iso-1 strain was constructed in the lab in 1986 (see FBrf0072686) but before the BAC and WGS genomic libraries used to sequence the genome were made in 1998 and 1999 respectively. The duplication in the annotated iso-1 strain is 31.4kb and involves three transcription units. Two of the transcription units are completely duplicated (Trpml/CG42638 and CG42529/ms(3)76Ca pairs), while only the coding exons of the third gene are duplicated, with several non-coding exons proximal to and outside of the tandem duplication (this pair corresponds to Gyc76C (CG42636) and CG42637).
The release 5 genome sequence has been assembled with a duplication of 26.68kb on chromosome arm 3L (the two copies of the duplication are at coordinates 19,706,343..19,733,031 and 19,737,759..19,764,445). The duplication is a polymorphic variant that is present in the sequenced strain, but does not exist in other D.melanogaster strains. The duplicated region contains coding sequences, such that duplicated copies of these coding regions exist in the release 5 genome annotation. The order of the duplicated segments is Doc{}1052--duplicated copy 1 (CG8743 CG42637 CG42529)--duplicated copy 2 (CG42638 CG42636 CG14101)--Doc{}1053--(5'UTR sequences of CG42636). The annotations CG8743 (trpml) and CG42638 are sequence-identical, and the annotations CG42529 and CG14101 are sequence-identical. In addition, the coding sequence (but not untranslated sequences) of the CG42636 annotation (Gyc76C) are duplicated, with the second copy of the coding sequences annotated as CG42637.
