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Gene Dmel\rad

General Information
Symbol	Dmel\rad	Species	D. melanogaster
Name	radish	Annotation symbol	CG42628
Feature type	protein_coding_gene	FlyBase ID	FBgn0261379
Gene Model Status	Current	Stock availability	3 publicly available
Also Known As	rsh
Genomic Location
Chromosome (arm)	X	Recombination map
Cytogenetic map	11E1-11E1	Sequence location	X:12,882,648..12,928,682 [+]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents modENCODE GBrowse	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene radish is referred to in FlyBase by the symbol Dmel\rad (CG42628, FBgn0261379). It is a protein_coding_gene from Drosophila melanogaster. An electronic pipeline based on InterPro domains suggests that it has the molecular function: calcium ion binding; phospholipase A2 activity. There is experimental evidence that it is involved in the biological process: regulation of heart contraction; anesthesia-resistant memory. 5 alleles are reported. The phenotype of these alleles is annotated with: mesothoracic tergum. It has 3 annotated transcripts and 3 annotated polypeptides. Protein features are: Phospholipase A2; Phospholipase A2, active site; Phospholipase A2, eukaryotic. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of low expression to a trough of no expression detected. Peak expression observed within 12-24 hour embryonic stages, during early larval stages, during late pupal stages. Summary of FlyAtlas Anatomical Expression Data: No expression detected in any larval or adult organs/tissues. Comments on Affy2 ProbeSet: ProbeSet 1637855_at completely aligns to an exonic region of the only FlyBase-annotated transcript isoform of rad. Gene sequence location is X:12882648..12928682.
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
Update Feed	Click the icon below to subscribe to this FlyBase record and receive updates automatically through your feed reader.
FB2012_01	Sequence features BKN29743 BKN30189 HFA19687 HFA19891
FB2011_10
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 11E1-11E1   Limits computationally determined from genome sequence between P{EP}EP1461 and P{EP}CG1640EP1626
Experimentally Determined Cytological Location
Cytogenetic map Notes References
Experimentally Determined Recombination Data
Location
Left of (cM)	f (Folkers et al., 1991)
Right of (cM)	v (Folkers et al., 1991)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\rad for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
	Gene model reviewed during 5.41 Gene splerge based on EST/cDNA data.
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) rad-RA FBtr0302269  NM_132620   2091   583 rad-RC FBtr0309876     2592   560 rad-RD FBtr0309877     2368   583
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein rad-PA   FBpp0291475   64.6   583   11.20     NP_572848   AAF48220 rad-PC   FBpp0301610   61.9   560   11.22       rad-PD   FBpp0301611   64.6   583   11.20
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Phospholipase A2, active site (IPR013090) Phospholipase A2 (IPR016090) Phospholipase A2, eukaryotic (IPR001211)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AE014298 AAF48220   AI107615   AI135423   AI293306   EW713098   EW713105   FE527474   FL502542   GH291423
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL	Q8SZ42 Q9VYG9 Q9VYH5
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
Polypeptide Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
High-Throughput Expression Data
or
See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes. modENCODE Temporal Expression Data for FBgn0261379    Styles Linear Logarithmic Heatmap    Scales max expr for FBgn0261379 Very low expression bin max Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of low expression to a trough of no expression detected. Peak expression observed within 12-24 hour embryonic stages, during early larval stages, during late pupal stages. [download data (TSV)] Guide to modENCODE expression level colors   No expression (0 - 0)   Extremely low expression (1 - 10)   Very low expression (11 - 100)   Low expression (101 - 400)   Moderate expression (401 - 1400)   Moderately high expression (1401 - 4000)   High expression (4001 - 10000)   Very high expression (10001 - 100000)   Extremely high expression (100001 - 2000000) Linear, scaled to maximum FBgn0261379 expression level Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    1 embryo 04-06hr    1 embryo 06-08hr    1 embryo 08-10hr    2 embryo 10-12hr    2 embryo 12-14hr    11 embryo 14-16hr    96 embryo 16-18hr    170 embryo 18-20hr    317 embryo 20-22hr    329 embryo 22-24hr    212 larva L1    330 larva L2    63 larva L3 12hr old    28 larva L3 puffstage 1-2    4 larva L3 puffstage 3-6    14 larva L3 puffstage 7-9    12 white prepupae new    11 white prepupae 12hr    17 white prepupae 24hr    36 pupae 2d postWPP    54 pupae 3d postWPP    66 pupae 4d postWPP    138 adult male 01day    65 adult male 05day    98 adult male 30day    79 adult female 01day    44 adult female 05day    10 adult female 30day    7 Expression Level Scale  None   Extremely low   Very low   Low  Linear, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    1 embryo 04-06hr    1 embryo 06-08hr    1 embryo 08-10hr    2 embryo 10-12hr    2 embryo 12-14hr    11 embryo 14-16hr    96 embryo 16-18hr  (170) embryo 18-20hr  (317) embryo 20-22hr  (329) embryo 22-24hr  (212) larva L1  (330) larva L2    63 larva L3 12hr old    28 larva L3 puffstage 1-2    4 larva L3 puffstage 3-6    14 larva L3 puffstage 7-9    12 white prepupae new    11 white prepupae 12hr    17 white prepupae 24hr    36 pupae 2d postWPP    54 pupae 3d postWPP    66 pupae 4d postWPP  (138) adult male 01day    65 adult male 05day    98 adult male 30day    79 adult female 01day    44 adult female 05day    10 adult female 30day    7 Expression Level Scale  None   Extremely low   Very low   Low  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    1 embryo 04-06hr    1 embryo 06-08hr    1 embryo 08-10hr    2 embryo 10-12hr    2 embryo 12-14hr    11 embryo 14-16hr    96 embryo 16-18hr    170 embryo 18-20hr    317 embryo 20-22hr    329 embryo 22-24hr    212 larva L1    330 larva L2    63 larva L3 12hr old    28 larva L3 puffstage 1-2    4 larva L3 puffstage 3-6    14 larva L3 puffstage 7-9    12 white prepupae new    11 white prepupae 12hr    17 white prepupae 24hr    36 pupae 2d postWPP    54 pupae 3d postWPP    66 pupae 4d postWPP    138 adult male 01day    65 adult male 05day    98 adult male 30day    79 adult female 01day    44 adult female 05day    10 adult female 30day    7 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    1 embryo 04-06hr    1 embryo 06-08hr    1 embryo 08-10hr    2 embryo 10-12hr    2 embryo 12-14hr    11 embryo 14-16hr    96 embryo 16-18hr    170 embryo 18-20hr    317 embryo 20-22hr    329 embryo 22-24hr    212 larva L1    330 larva L2    63 larva L3 12hr old    28 larva L3 puffstage 1-2    4 larva L3 puffstage 3-6    14 larva L3 puffstage 7-9    12 white prepupae new    11 white prepupae 12hr    17 white prepupae 24hr    36 pupae 2d postWPP    54 pupae 3d postWPP    66 pupae 4d postWPP    138 adult male 01day    65 adult male 05day    98 adult male 30day    79 adult female 01day    44 adult female 05day    10 adult female 30day    7 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    1 embryo 04-06hr    1 embryo 06-08hr    1 embryo 08-10hr    2 embryo 10-12hr    2 embryo 12-14hr    11 embryo 14-16hr    96 embryo 16-18hr    170 embryo 18-20hr    317 embryo 20-22hr    329 embryo 22-24hr    212 larva L1    330 larva L2    63 larva L3 12hr old    28 larva L3 puffstage 1-2    4 larva L3 puffstage 3-6    14 larva L3 puffstage 7-9    12 white prepupae new    11 white prepupae 12hr    17 white prepupae 24hr    36 pupae 2d postWPP    54 pupae 3d postWPP    66 pupae 4d postWPP    138 adult male 01day    65 adult male 05day    98 adult male 30day    79 adult female 01day    44 adult female 05day    10 adult female 30day    7 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  log, scaled to maximum FBgn0261379 expression level Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    1 embryo 04-06hr    1 embryo 06-08hr    1 embryo 08-10hr    2 embryo 10-12hr    2 embryo 12-14hr    11 embryo 14-16hr    96 embryo 16-18hr    170 embryo 18-20hr    317 embryo 20-22hr    329 embryo 22-24hr    212 larva L1    330 larva L2    63 larva L3 12hr old    28 larva L3 puffstage 1-2    4 larva L3 puffstage 3-6    14 larva L3 puffstage 7-9    12 white prepupae new    11 white prepupae 12hr    17 white prepupae 24hr    36 pupae 2d postWPP    54 pupae 3d postWPP    66 pupae 4d postWPP    138 adult male 01day    65 adult male 05day    98 adult male 30day    79 adult female 01day    44 adult female 05day    10 adult female 30day    7 Expression Level Scale  None   Extremely low   Very low   Low   Moderate  log, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    1 embryo 04-06hr    1 embryo 06-08hr    1 embryo 08-10hr    2 embryo 10-12hr    2 embryo 12-14hr    11 embryo 14-16hr    96 embryo 16-18hr  (170) embryo 18-20hr  (317) embryo 20-22hr  (329) embryo 22-24hr  (212) larva L1  (330) larva L2    63 larva L3 12hr old    28 larva L3 puffstage 1-2    4 larva L3 puffstage 3-6    14 larva L3 puffstage 7-9    12 white prepupae new    11 white prepupae 12hr    17 white prepupae 24hr    36 pupae 2d postWPP    54 pupae 3d postWPP    66 pupae 4d postWPP  138 adult male 01day    65 adult male 05day    98 adult male 30day    79 adult female 01day    44 adult female 05day    10 adult female 30day    7 Expression Level Scale  None   Extremely low   Very low   Low  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    1 embryo 04-06hr    1 embryo 06-08hr    1 embryo 08-10hr    2 embryo 10-12hr    2 embryo 12-14hr    11 embryo 14-16hr    96 embryo 16-18hr    170 embryo 18-20hr    317 embryo 20-22hr    329 embryo 22-24hr    212 larva L1    330 larva L2    63 larva L3 12hr old    28 larva L3 puffstage 1-2    4 larva L3 puffstage 3-6    14 larva L3 puffstage 7-9    12 white prepupae new    11 white prepupae 12hr    17 white prepupae 24hr    36 pupae 2d postWPP    54 pupae 3d postWPP    66 pupae 4d postWPP    138 adult male 01day    65 adult male 05day    98 adult male 30day    79 adult female 01day    44 adult female 05day    10 adult female 30day    7 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    1 embryo 04-06hr    1 embryo 06-08hr    1 embryo 08-10hr    2 embryo 10-12hr    2 embryo 12-14hr    11 embryo 14-16hr    96 embryo 16-18hr    170 embryo 18-20hr    317 embryo 20-22hr    329 embryo 22-24hr    212 larva L1    330 larva L2    63 larva L3 12hr old    28 larva L3 puffstage 1-2    4 larva L3 puffstage 3-6    14 larva L3 puffstage 7-9    12 white prepupae new    11 white prepupae 12hr    17 white prepupae 24hr    36 pupae 2d postWPP    54 pupae 3d postWPP    66 pupae 4d postWPP    138 adult male 01day    65 adult male 05day    98 adult male 30day    79 adult female 01day    44 adult female 05day    10 adult female 30day    7 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    1 embryo 04-06hr    1 embryo 06-08hr    1 embryo 08-10hr    2 embryo 10-12hr    2 embryo 12-14hr    11 embryo 14-16hr    96 embryo 16-18hr    170 embryo 18-20hr    317 embryo 20-22hr    329 embryo 22-24hr    212 larva L1    330 larva L2    63 larva L3 12hr old    28 larva L3 puffstage 1-2    4 larva L3 puffstage 3-6    14 larva L3 puffstage 7-9    12 white prepupae new    11 white prepupae 12hr    17 white prepupae 24hr    36 pupae 2d postWPP    54 pupae 3d postWPP    66 pupae 4d postWPP    138 adult male 01day    65 adult male 05day    98 adult male 30day    79 adult female 01day    44 adult female 05day    10 adult female 30day    7 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     FlyAtlas Anatomical Expression Data for FBgn0261379    Styles Linear Logarithmic Heatmap Back-to-back    Scales max expr for FBgn0261379 Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: No expression detected in any larval or adult organs/tissues. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (1000 - 25000) Linear, scaled to maximum FBgn0261379 expression level Tissue   Expression Level Larval Central Nervous System    5.55 Larval Midgut    3.9 Larval Hindgut    3.3 Larval Malpighian Tubules    5.4 Larval Fat Body    5.6 Larval Salivary Gland    7.7 Larval Trachea    1.375 Larval Carcass    3.1 Adult Head    2.6 Adult Eye    2.6 Adult Brain no informative data Adult Thoracic-Abdominal Ganglion    6 Adult Crop    4.7 Adult Midgut    3.7 Adult Hindgut    6.1 Adult Malpighian Tubules    2.5 Adult Fat Body    2.3 Adult Salivary Gland    2.6 Adult Heart    1.125 Adult VirginFemale Spermatheca    1.4 Adult InseminatedFemale Spermatheca    5.4 Adult Ovary    1.2 Adult Testis    2.7 Adult Male Accessory Gland    5.3 Adult Carcass    2.1 Expression Level Scale  None   Low  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    5.55 Larval Midgut    3.9 Larval Hindgut    3.3 Larval Malpighian Tubules    5.4 Larval Fat Body    5.6 Larval Salivary Gland    7.7 Larval Trachea    1.375 Larval Carcass    3.1 Adult Head    2.6 Adult Eye    2.6 Adult Brain no informative data Adult Thoracic-Abdominal Ganglion    6 Adult Crop    4.7 Adult Midgut    3.7 Adult Hindgut    6.1 Adult Malpighian Tubules    2.5 Adult Fat Body    2.3 Adult Salivary Gland    2.6 Adult Heart    1.125 Adult VirginFemale Spermatheca    1.4 Adult InseminatedFemale Spermatheca    5.4 Adult Ovary    1.2 Adult Testis    2.7 Adult Male Accessory Gland    5.3 Adult Carcass    2.1 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    5.55 Larval Midgut    3.9 Larval Hindgut    3.3 Larval Malpighian Tubules    5.4 Larval Fat Body    5.6 Larval Salivary Gland    7.7 Larval Trachea    1.375 Larval Carcass    3.1 Adult Head    2.6 Adult Eye    2.6 Adult Brain no informative data Adult Thoracic-Abdominal Ganglion    6 Adult Crop    4.7 Adult Midgut    3.7 Adult Hindgut    6.1 Adult Malpighian Tubules    2.5 Adult Fat Body    2.3 Adult Salivary Gland    2.6 Adult Heart    1.125 Adult VirginFemale Spermatheca    1.4 Adult InseminatedFemale Spermatheca    5.4 Adult Ovary    1.2 Adult Testis    2.7 Adult Male Accessory Gland    5.3 Adult Carcass    2.1 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    5.55 Larval Midgut    3.9 Larval Hindgut    3.3 Larval Malpighian Tubules    5.4 Larval Fat Body    5.6 Larval Salivary Gland    7.7 Larval Trachea    1.375 Larval Carcass    3.1 Adult Head    2.6 Adult Eye    2.6 Adult Brain no informative data Adult Thoracic-Abdominal Ganglion    6 Adult Crop    4.7 Adult Midgut    3.7 Adult Hindgut    6.1 Adult Malpighian Tubules    2.5 Adult Fat Body    2.3 Adult Salivary Gland    2.6 Adult Heart    1.125 Adult VirginFemale Spermatheca    1.4 Adult InseminatedFemale Spermatheca    5.4 Adult Ovary    1.2 Adult Testis    2.7 Adult Male Accessory Gland    5.3 Adult Carcass    2.1 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to maximum FBgn0261379 expression level Tissue   Expression Level Larval Central Nervous System    5.55 Larval Midgut    3.9 Larval Hindgut    3.3 Larval Malpighian Tubules    5.4 Larval Fat Body    5.6 Larval Salivary Gland    7.7 Larval Trachea    1.375 Larval Carcass    3.1 Adult Head    2.6 Adult Eye    2.6 Adult Brain no informative data Adult Thoracic-Abdominal Ganglion    6 Adult Crop    4.7 Adult Midgut    3.7 Adult Hindgut    6.1 Adult Malpighian Tubules    2.5 Adult Fat Body    2.3 Adult Salivary Gland    2.6 Adult Heart    1.125 Adult VirginFemale Spermatheca    1.4 Adult InseminatedFemale Spermatheca    5.4 Adult Ovary    1.2 Adult Testis    2.7 Adult Male Accessory Gland    5.3 Adult Carcass    2.1 Expression Level Scale  None   Low  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    5.55 Larval Midgut    3.9 Larval Hindgut    3.3 Larval Malpighian Tubules    5.4 Larval Fat Body    5.6 Larval Salivary Gland    7.7 Larval Trachea    1.375 Larval Carcass    3.1 Adult Head    2.6 Adult Eye    2.6 Adult Brain no informative data Adult Thoracic-Abdominal Ganglion    6 Adult Crop    4.7 Adult Midgut    3.7 Adult Hindgut    6.1 Adult Malpighian Tubules    2.5 Adult Fat Body    2.3 Adult Salivary Gland    2.6 Adult Heart    1.125 Adult VirginFemale Spermatheca    1.4 Adult InseminatedFemale Spermatheca    5.4 Adult Ovary    1.2 Adult Testis    2.7 Adult Male Accessory Gland    5.3 Adult Carcass    2.1 Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    5.55 Larval Midgut    3.9 Larval Hindgut    3.3 Larval Malpighian Tubules    5.4 Larval Fat Body    5.6 Larval Salivary Gland    7.7 Larval Trachea    1.375 Larval Carcass    3.1 Adult Head    2.6 Adult Eye    2.6 Adult Brain no informative data Adult Thoracic-Abdominal Ganglion    6 Adult Crop    4.7 Adult Midgut    3.7 Adult Hindgut    6.1 Adult Malpighian Tubules    2.5 Adult Fat Body    2.3 Adult Salivary Gland    2.6 Adult Heart    1.125 Adult VirginFemale Spermatheca    1.4 Adult InseminatedFemale Spermatheca    5.4 Adult Ovary    1.2 Adult Testis    2.7 Adult Male Accessory Gland    5.3 Adult Carcass    2.1 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    5.55 Larval Midgut    3.9 Larval Hindgut    3.3 Larval Malpighian Tubules    5.4 Larval Fat Body    5.6 Larval Salivary Gland    7.7 Larval Trachea    1.375 Larval Carcass    3.1 Adult Head    2.6 Adult Eye    2.6 Adult Brain no informative data Adult Thoracic-Abdominal Ganglion    6 Adult Crop    4.7 Adult Midgut    3.7 Adult Hindgut    6.1 Adult Malpighian Tubules    2.5 Adult Fat Body    2.3 Adult Salivary Gland    2.6 Adult Heart    1.125 Adult VirginFemale Spermatheca    1.4 Adult InseminatedFemale Spermatheca    5.4 Adult Ovary    1.2 Adult Testis    2.7 Adult Male Accessory Gland    5.3 Adult Carcass    2.1 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain no informative data Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    2.6   NA  Eye    2.6   NA  Brain    no informative data   5.55  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    6   NA  Crop    4.7   3.9  Midgut    3.7   3.3  Hindgut    6.1   5.4  Malpighian Tubules    2.5   5.6  Fat Body    2.3   7.7  Salivary Gland    2.6   NA  Heart    1.125   1.375  Trachea    NA   NA  VirginFemale Spermatheca    1.4   NA  InseminatedFemale Spermatheca    5.4   NA  Ovary    1.2   NA  Testis    2.7   NA  Male Accessory Gland    5.3   3.1  Carcass    2.1 modENCODE Temporal Expression Data (Graveley et al., 2011) FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
Expression Clusters
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0261379
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele semi-lethal | pupal stage, with Scer\GAL4pnr-MD237 radGD8769 Other Phenotypes Allele behavior defective rad1 learning defective | recessive rad1 learning defective | semidominant rad1 memory defective rad1 visible, with Scer\GAL4pnr-MD237 radGD8769 Phenotype manifest in Allele adult heart | P-stage rad1 mesothoracic tergum, with Scer\GAL4pnr-MD237 radGD8769
Classical Alleles ( 2 )
For All Classical Alleles Show
Allele of rad Class Mutagen Stocks Known lesion rad1 0 Yes radunspecified 0 --
Alleles Carried on Transgenic Constructs ( 3 )
For All Alleles Carried on Transgenic Constructs Show
Allele of rad Class Mutagen Stocks Known lesion radGD8769 in vitro construct - RNAi in vitro construct - regulatory fusion 2 Yes radKK109743 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes radhs.PF in vitro construct - regulatory fusion 0 Yes
Aneuploid Aberrations
Disrupted in	Df(1)C246 (Folkers et al., 1991, Folkers et al., 1993) Df(1)JA26 (Folkers et al., 1993, Folkers et al., 1991) Df(1)N105 (Tully et al., 1994, Folkers et al., 1991, Folkers et al., 1993)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD3339} NA P{KK109743} NA heat-shock construct P{hs-rad.F} NA
Insertions
	Type of insertions Name Expression data
Gene Ontology: Function, Process & Cellular Component ( 7 unique terms )
Terms Based on Experimental Evidence ( 2 terms )
Molecular Function ( 0 terms)
Biological Process
CV term Evidence References
anesthesia-resistant memory inferred from direct assay (Lee et al., 2011) regulation of heart contraction inferred from mutant phenotype (Johnson et al., 2002)
Cellular Component ( 0 terms)
Terms Based on Predictions or Assertions ( 6 terms )
Molecular Function
CV term Evidence References
calcium ion binding inferred from electronic annotation with InterPro:IPR001211 (FlyBase Curators et al., 2004-) phospholipase A2 activity inferred from electronic annotation with InterPro:IPR001211, InterPro:IPR013090 (FlyBase Curators et al., 2004-)
Biological Process
CV term Evidence References
anesthesia-resistant memory traceable author statement (Heisenberg, 2003) lipid catabolic process inferred from electronic annotation with InterPro:IPR001211, InterPro:IPR013090 (FlyBase Curators et al., 2004-) olfactory learning traceable author statement (Roman and Davis, 2001) phospholipid metabolic process inferred from electronic annotation with InterPro:IPR013090 (FlyBase Curators et al., 2004-)
Cellular Component ( 0 terms)
Sequence Ontology: Class of Gene
	nuclear_gene (FlyBase Genome Annotators, 2009) protein_coding_gene (FlyBase Genome Annotators, 2009)
Interactions & Pathways
Summary of Physical Interactions
Protein-protein
Interacting group Assay References
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions rad allele Gene References
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 58639 DroID - A comprehensive database of gene and protein interactions. • FBgn0261379 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 32251
Orthologs
Genome-wide drosophilid orthologs	Dana\GF21400 Dana\GF22231 Dere\GG17751 Dere\GG17755 Dgri\GH12690 Dgri\GH24429 Dmoj\GI16287 Dmoj\GI16365 Dper\GL14950 Dpse\GA13913 Dpse\GA18124 Dsec\GM11596 Dsec\GM11601 Dsim\GD17097 Dsim\GD17099 Dvir\GJ16527 Dvir\GJ16735 Dwil\GK17378 Dwil\GK25187 Dyak\GE17039 Dyak\GE17044
Curated drosophilid orthologs	Dpse\GA13913
Linkouts	OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • NV50012 LH22420 ISCW017634 FBgn0234523 FBgn0227146 FBgn0203711 FBgn0188667 FBgn0166539 JGI_V11_104136 FBgn0073945 FBgn0139036 FBgn0131885 FBgn0109973 FBgn0098402 CPIJ010273 ACYPI004358 GB12580 AGAP002116 AAEL005089 PB22927 PHUM299660 GLEAN_07720
Stocks & Reagents
Stocks Listed in FlyBase ( 3 )
VDRC	v101811 P{KK109743}VIE-260B v39931 w1118; P{GD8769}v39931 v39932 w1118; P{GD8769}v39932
Genomic Clones ( 2 )
	BACR06C04 BACR39D14 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 7 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones
Other clones
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	GH05389 GH13175 GH16473
Other clones	DMG1-chrX.13.089.a DMG3-chrX.12616.pred.a DMG4-chrX.23.023.pred.a DMG6-chrX.22.045.pred.a
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0261379 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 32251
Antibody Information
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of
Source for database merge of	Source for merge of: rad CG15720 (Folkers et al., 2006)
Additional comments	The CG15720-RB transcript was created in release 5.1 of the genome annotation. This annotation contained sequences corresponding to the IP18538 cDNA clone (BT030283) at its 3' end, and was annotated as part of the CG15720 annotation (which corresponds to the rad locus). In release 5.22 of the genome annotation, the CG15720-RB transcript has been deleted, and sequences corresponding to the IP18538 cDNA clone (BT030283) have instead been joined to sequences from the CG18646 annotation, to form a new annotation, CG42629. The annotation corresponding to the rad locus has been renamed from CG15720 to CG42628 to avoid confusion and consists of a single transcript (CG42628-RA) in release 5.22 of the genome annotation. (FlyBase Genome Annotators, 2009) The gene corresponding to genome annotation CG42237 was named "radish" in FBrf0174475 due to an insertion allele in CG42237 (formerly known as CG4346). The group subsequently published a retraction explaining that this was a mistake and the radish phenotype is not caused by mutation of the CG42237 gene. (Chiang et al., 2007)
Other Comments
	Anaesthesia resistant memory is, though long term memory is not disrupted by mutation at rad. (Tully, 1995) Anesthesia resistant memory is cycloheximide insensitive but is disrupted in rad mutants. Long term memory is cycloheximide sensitive, but is not disrupted by rad mutants. (Tully et al., 1994) The behaviour of rad flies and the genetics of the rad gene have been characterised. Consolidated memory is lacking in rad flies. (Folkers et al., 1993)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_132620 RefSeq (Proteins) • NP_572848 DDBJ / EMBL / GenBank • AAF48220 Entrez Gene - A searchable database of RefSeq genes. • 32251 UniProtKB/TrEMBL • Q8SZ42 Q9VYG9 Q9VYH5
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Phospholipase A2, active site (IPR013090) Phospholipase A2 (IPR016090) Phospholipase A2, eukaryotic (IPR001211)
Linkouts
	BioGRID - A database of protein and genetic interactions • 58639 DroID - A comprehensive database of gene and protein interactions. • FBgn0261379 DRSC - Results from RNAi screens. • FBgn0261379 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0261379 FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0261379 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 32251 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 32251 modMine - Data generated by the modENCODE project. • FBgn0261379 OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • NV50012 LH22420 ISCW017634 FBgn0234523 FBgn0227146 FBgn0203711 FBgn0188667 FBgn0166539 JGI_V11_104136 FBgn0073945 FBgn0139036 FBgn0131885 FBgn0109973 FBgn0098402 CPIJ010273 ACYPI004358 GB12580 AGAP002116 AAEL005089 PB22927 PHUM299660 GLEAN_07720
Synonyms & Secondary IDs ( 7 )
Reported As
Symbol Synonym	CG4346   CG15720 (Keleman et al., 2009.8.5) CG42628 (FlyBase Genome Annotators, 2009, ) rad   radish (Drier et al., 2002) rsh (Folkers et al., 2006, Waddell and Quinn, 2001, Hitier et al., 1998, Dubnau and Tully, 1998, Meller and Davis, 1996, Folkers et al., 1993, van Swinderen, 2007, Dubnau et al., 2003, Chabaud et al., 2009, Lee et al., 2011)
Name Synonym	radish (van Swinderen and Brembs, 2010, Waddell and Quinn, 2001, Folkers and Quinn, 1997, Folkers et al., 2006, Dubnau et al., 2003, Drier et al., 2002, Chabaud et al., 2009, Qin and Dubnau, 2010, Lee et al., 2011) raish (Krashes and Waddell, 2008)
Secondary FlyBase IDs
	FBgn0003193 FBgn0030442 FBgn0030450 FBgn0250864 FBgn0259161 FBgn0261351
References ( 53 )
Generate a list of	All references relating to this gene ( 53 )
List References by type	Research paper  ( 15 ) Supplementary material  ( 1 ) Review  ( 22 ) Retraction  ( 1 ) Personal communication to FlyBase  ( 3 ) Abstract  ( 8 ) FlyBase analysis  ( 3 )
Recent research papers ( 3 )
	Lee et al., 2011, Proc. Natl. Acad. Sci. U.S.A. 108(33): 13794--13799 Serotonin-mushroom body circuit modulating the formation of anesthesia-resistant memory in Drosophila. [FBrf0214737] Qin and Dubnau, 2010, Genes Brain Behav. 9(2): 203--212 Genetic disruptions of Drosophila Pavlovian learning leave extinction learning intact. [FBrf0210733] van Swinderen and Brembs, 2010, J. Neurosci. 30(3): 1003--1014 Attention-like deficit and hyperactivity in a Drosophila memory mutant. [FBrf0209790] Show all research papers ...
Recent reviews (0)
	All reviews listed in FlyBase were published before 2010 Show reviews ...