FlyBase Gene Report: Dmel\CG17528

General Information

Symbol

Dmel\CG17528

Species

D. melanogaster

Name

Annotation Symbol

CG17528

Feature Type

protein_coding_gene

FlyBase ID

FBgn0261387

Gene Model Status

Current

Stock Availability

7 publicly available

Enzyme Name (EC)

calcium/calmodulin-dependent protein kinase (2.7.11.17)

Gene Summary

Contribute a Gene Snapshot for this gene.

All Summaries

Alliance
Auto summary
Gene Group
Interactive Fly

Also Known As

zyg8

Key Links

Genomic Location

Cytogenetic map

41C2-41C2

Sequence location

2R:4,815,426..4,824,319 [-]

Recombination map

2-55

RefSeq locus

NT_033778 REGION:4815426..4824319

Sequence

Get Decorated FASTA

Genomic Maps

JBrowse

Other Genome Views

The following external sites may use different assemblies or annotations than FlyBase.

Function

Gene Ontology (GO) Annotations (9 terms)

Molecular Function (6 terms)

Terms Based on Experimental Evidence (0 terms)

Terms Based on Predictions or Assertions (6 terms)

CV Term

Evidence

References

enables ATP binding

inferred from electronic annotation with InterPro:IPR000719, InterPro:IPR017441

(InterPro Project Members, 2004-)

enables calcium-dependent protein serine/threonine kinase activity

inferred from biological aspect of ancestor with PANTHER:PTN000681419

(GO Reference Genome Project, 2011-)

enables calcium/calmodulin-dependent protein kinase activity

inferred from biological aspect of ancestor with PANTHER:PTN000681419

(GO Reference Genome Project, 2011-)

enables calmodulin binding

inferred from biological aspect of ancestor with PANTHER:PTN000681419

(GO Reference Genome Project, 2011-)

enables protein kinase activity

inferred from electronic annotation with InterPro:IPR000719, InterPro:IPR008271

(InterPro Project Members, 2004-)

enables protein serine/threonine kinase activity

inferred from sequence or structural similarity with UniProtKB:P0C1X8

(Gene Ontology Curators, 2002-)

Biological Process (1 term)

Terms Based on Experimental Evidence (0 terms)

Terms Based on Predictions or Assertions (1 term)

CV Term

Evidence

References

involved_in intracellular signal transduction

inferred from electronic annotation with InterPro:IPR003533, InterPro:IPR036572

(InterPro Project Members, 2004-)

inferred from biological aspect of ancestor with PANTHER:PTN000681419

(GO Reference Genome Project, 2011-)

Cellular Component (2 terms)

Terms Based on Experimental Evidence (0 terms)

Terms Based on Predictions or Assertions (2 terms)

CV Term

Evidence

References

is_active_in cytoplasm

inferred from biological aspect of ancestor with PANTHER:PTN000681419

(GO Reference Genome Project, 2011-)

is_active_in nucleus

inferred from biological aspect of ancestor with PANTHER:PTN000681419

(GO Reference Genome Project, 2011-)

Gene Group (FlyBase)

CALCIUM/CALMODULIN-DEPENDENT PROTEIN KINASES

Protein Family (UniProt)

Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CaMK subfamily. (Q7PLI7)

Protein Signatures (InterPro)

Catalytic Activity (EC/Rhea)

calcium/calmodulin-dependent protein kinase activity

(1) L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+) (2.7.11.17)

(2) L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+) (2.7.11.17)

Summaries

Gene Group (FlyBase)

CALCIUM/CALMODULIN-DEPENDENT PROTEIN KINASES -: The Calcium/Calmodulin-dependent kinase family are serine/threonine kinases which, in general, prefer substrates containing basic residues. Many, but not all, members are regulated by calcium or calmodulin. (Adapted from FBrf0132098).

Gene Model and Products

Number of Transcripts

Number of Unique Polypeptides

Please see the JBrowse view of Dmel\CG17528 for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)

Isoform displayed:

Pfam protein domains

InterPro name

classification

start

end

Protein Domains (via SMART)

Isoform displayed:

SMART protein domains

InterPro name

classification

start

end

Structure

Protein 3D structure (Predicted by AlphaFold) (AlphaFold entry Q7PLI7)

If you don't see a structure in the viewer, refresh your browser.

Model Confidence:

Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Experimentally Determined Structures

Crossreferences

Comments on Gene Model

Gene model reviewed during 5.47

Annotated transcripts do not represent all supported alternative splices within 5' UTR.

Low-frequency RNA-Seq exon junction(s) not annotated.

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Assoc. CDS (aa)

CG17528-RC

FBtr0111274

NM_001042998

2645

748

CG17528-RD

FBtr0111277

NM_001042997

4686

748

Additional Transcript Data and Comments

Reported size (kB)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kDa)

Length (aa)

Theoretical pI

UniProt

RefSeq ID

GenBank

CG17528-PC

FBpp0110466

83.0

748

7.83

FBpp0110579

83.0

748

7.83

Q7PLI7

NP_001036462

EAA46000

Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

748 aa isoforms: CG17528-PC, CG17528-PD

Additional Polypeptide Data and Comments

Reported size (kDa)

Comments

External Data

Crossreferences

InterPro - A database of protein families, domains and functional sites

Linkouts

Sequences Consistent with the Gene Model

Nucleotide / Polypeptide Records

UniProt

Q7PLI7

Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\CG17528 using the Feature Mapper tool.

External Data

Crossreferences

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

CG17528_1

Linkouts

Expression Data

Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

0.01

Transcript Expression

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Polypeptide Expression

mass spectroscopy

Stage

Tissue/Position (including subcellular localization)

Reference

adult stage

adult head

• membrane

(Aradska et al., 2015)

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Evidence

References

Expression Deduced from Reporters

High-Throughput Expression Data

Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\CG17528 in JBrowse

RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region

View exonic expression by developmental stage for Dmel\CG17528

View exonic expression by tissue for Dmel\CG17528

Bulk Downloads

RNA-Seq RPKM values for all genes

Reference

See Gelbart and Emmert, 2013 for analysis details and data files for all genes.

Developmental Proteome: Life Cycle

Developmental Proteome: Embryogenesis

External Data and Images

Linkouts

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

3355134/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0261387

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0032999

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0261387

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG40283

Flygut - An atlas of the Drosophila adult midgut

FBgn0261387

Images

FlyBase Wiki

Image Based Resources

Alleles, Insertions, Transgenic Constructs, and Aberrations

Classical and Insertion Alleles ( 5 )

For All Classical and Insertion Alleles Show

Other relevant insertions

Transgenic Constructs ( 6 )

For All Alleles Carried on Transgenic Constructs Show

Transgenic constructs containing/affecting coding region of CG17528

Transgenic constructs containing regulatory region of CG17528

Aberrations (Deficiencies and Duplications) ( 5 )

Inferred from experimentation ( 5 )

Gene disrupted in

Df(2R)conu⁶

(Neisch et al., 2013)

Df(2R)M41A2

(Myster et al., 2004)

Df(2R)M41A8

(Myster et al., 2004)

Df(2R)M41A10

(Myster et al., 2004)

Df(2R)Nipped-D

(Myster et al., 2004)

Inferred from location ( 1 )

Dp(2;3)GV-CH321-73A16

Variants

Variant Molecular Consequences

Alleles Representing Disease-Implicated Variants

Phenotypes

For more details about a specific phenotype click on the relevant allele symbol.

Sterility

Allele

female semi-sterile, with Scer\GAL4^{VP16.mat.αTub67C}

CG17528^HMJ02234

Other Phenotypes

Allele

abnormal neuroanatomy | adult stage, with Scer\GAL4^peb-GAL4

CG17528^HMJ02234

Phenotype manifest in

Allele

adult antennal lobe glomerulus, with Scer\GAL4^peb-GAL4

CG17528^HMJ02234

adult antennal olfactory receptor neuron, with Scer\GAL4^peb-GAL4

CG17528^HMJ02234

Orthologs

Downloads

Download All DIOPT Orthologs

Human Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Homo sapiens (Human) (108)

Hsap\DCLK2

12 of 14

Yes

Hsap\DCLK1

11 of 14

Yes

Hsap\CAMK4

4 of 14

Hsap\DCLK3

4 of 14

Yes

Hsap\DCX

4 of 14

Yes

3 of 14

3 of 14

3 of 14

3 of 14

3 of 14

3 of 14

3 of 14

3 of 14

Yes

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

Yes

Hsap\DAPK3

2 of 14

Yes

Hsap\DCDC2B

2 of 14

Yes

Hsap\DCDC2C

2 of 14

Yes

Hsap\DCDC2

2 of 14

Yes

2 of 14

2 of 14

2 of 14

2 of 14

Yes

Hsap\RP1L1

2 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Hsap\ULK1

1 of 14

Hsap\ULK2

1 of 14

Hsap\ULK3

1 of 14

Model Organism Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Rattus norvegicus (Norway rat) (60)

Rnor\Dclk2

11 of 14

Yes

Rnor\Dclk1

9 of 14

Yes

Rnor\Dcx

5 of 14

Yes

4 of 14

3 of 14

3 of 14

3 of 14

3 of 14

Yes

Rnor\Stk33

3 of 14

Yes

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

Yes

2 of 14

2 of 14

2 of 14

2 of 14

Yes

Rnor\Rp1

2 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Rnor\Dcdc2c

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Rnor\Ulk1

1 of 14

Rnor\Ulk2

1 of 14

Rnor\Ulk3

1 of 14

Mus musculus (laboratory mouse) (68)

Mmus\Dclk2

12 of 14

Yes

Mmus\Dclk1

11 of 14

Yes

Mmus\Dcx

5 of 14

Yes

4 of 14

3 of 14

3 of 14

3 of 14

3 of 14

Yes

Mmus\Pnck

3 of 14

Mmus\Pskh1

3 of 14

Mmus\Stk33

3 of 14

Yes

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

Yes

Mmus\Dcdc2b

2 of 14

Yes

Mmus\Dcdc2c

2 of 14

Yes

Mmus\Phkg1

2 of 14

Mmus\Phkg2

2 of 14

Mmus\Rp1l1

2 of 14

Yes

Mmus\Rp1

2 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Mmus\Ulk1

1 of 14

Mmus\Ulk2

1 of 14

Mmus\Ulk3

1 of 14

Xenopus tropicalis (Western clawed frog) (64)

Xtro\dclk1

9 of 13

Yes

Xtro\dclk2

7 of 13

Yes

Xtro\dcx

3 of 13

Yes

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

Yes

2 of 13

2 of 13

2 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Yes

Xtro\dapk3

1 of 13

Xtro\dcdc2b

1 of 13

Yes

Xtro\dcdc2

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Danio rerio (Zebrafish) (79)

Drer\dclk2a

12 of 14

Yes

Drer\dclk1a

11 of 14

Yes

Drer\dclk1b

9 of 14

Yes

4 of 14

4 of 14

3 of 14

3 of 14

3 of 14

3 of 14

3 of 14

3 of 14

3 of 14

Yes

Drer\pnck

3 of 14

Drer\pskh1

3 of 14

Drer\stk33

3 of 14

Yes

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

Yes

Drer\dapk3

2 of 14

Yes

Drer\dcdc2b

2 of 14

Yes

Drer\dclk3

2 of 14

Yes

Drer\mylk3

2 of 14

Drer\phkg2

2 of 14

Drer\rp1l1a

2 of 14

Yes

2 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Drer\dcdc2c

1 of 14

Yes

Drer\ikbkb

1 of 14

Drer\ikbke

1 of 14

Drer\LOC100537554

1 of 14

Yes

Drer\LOC101887148

1 of 14

Yes

Drer\map3k3

1 of 14

Drer\map3k14a

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Drer\ulk1a

1 of 14

Drer\ulk1b

1 of 14

Drer\ulk2

1 of 14

Caenorhabditis elegans (Nematode, roundworm) (46)

Cele\zyg-8

11 of 14

Yes

3 of 14

3 of 14

2 of 14

2 of 14

2 of 14

Yes

2 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Cele\R02C2.1

1 of 14

Cele\rpi-1

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Anopheles gambiae (African malaria mosquito) (32)

Agam\AgaP_AGAP009034

11 of 12

Yes

3 of 12

2 of 12

2 of 12

2 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

Arabidopsis thaliana (thale-cress) (94)

Atha\CDPK1

3 of 13

Yes

Atha\CDPK2

3 of 13

Yes

Atha\CDPK9

3 of 13

Yes

Atha\CPK1

3 of 13

Yes

Atha\CPK2

3 of 13

Yes

Atha\CPK4

3 of 13

Yes

Atha\CPK7

3 of 13

Yes

Atha\CPK9

3 of 13

Yes

Atha\CPK14

3 of 13

Yes

Atha\CPK15

3 of 13

Yes

Atha\CPK17

3 of 13

Yes

Atha\CPK19

3 of 13

Yes

Atha\CPK21

3 of 13

Yes

Atha\CPK23

3 of 13

Yes

Atha\CPK25

3 of 13

Yes

Atha\CPK29

3 of 13

Yes

Atha\CPK30

3 of 13

Yes

Atha\CPK33

3 of 13

Yes

Atha\CPK34

3 of 13

Yes

Atha\PEPKR1

3 of 13

Yes

Atha\PEPKR2

3 of 13

Yes

Atha\PPCK2

3 of 13

Yes

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

1 of 13

1 of 13

1 of 13

Yes

Atha\AT1G79570

1 of 13

Atha\AT2G29220

1 of 13

Yes

Atha\AT2G45670

1 of 13

Atha\AT3G50730

1 of 13

Atha\AT3G53380

1 of 13

Yes

Atha\AT3G53930

1 of 13

Atha\AT3G56370

1 of 13

Atha\AT3G59740

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Yes

Atha\LYK3

1 of 13

Yes

Atha\MAP3KA

1 of 13

Atha\MAPKKK14

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Yes

Saccharomyces cerevisiae (Brewer's yeast) (18)

Scer\CMK1

2 of 13

Yes

Scer\CMK2

2 of 13

Yes

Scer\DUN1

2 of 13

Yes

Scer\TDA1

2 of 13

Yes

Scer\ATG1

1 of 13

Scer\BUD32

1 of 13

Scer\FMP48

1 of 13

Yes

Scer\IKS1

1 of 13

Yes

Scer\KIC1

1 of 13

Scer\KSP1

1 of 13

Yes

Scer\MEK1

1 of 13

Scer\NNK1

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Schizosaccharomyces pombe (Fission yeast) (12)

Spom\cmk1

2 of 12

Yes

Spom\mek1

2 of 12

Yes

Spom\srk1

2 of 12

Yes

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

Yes

Spom\mkh1

1 of 12

Spom\plo1

1 of 12

Spom\ran1

1 of 12

Yes

Spom\win1

1 of 12

Escherichia coli (enterobacterium) (0)

Other Organism Orthologs (via OrthoDB)

Data provided directly from OrthoDB:CG17528. Refer to their site for version information.

Paralogs

Downloads

Download All DIOPT Paralogs

Paralogs (via DIOPT v9.1)

Gene Symbol

Score

Source

Alignment

Drosophila melanogaster (Fruit fly) (41)

CaMKI

3 of 13

Lk6

3 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

Ack

1 of 13

Alk

1 of 13

Ask1

1 of 13

Atg1

1 of 13

babo

1 of 13

Btk

1 of 13

btl

1 of 13

cdi

1 of 13

Cdk5

1 of 13

CG10126

1 of 13

CG31345

1 of 13

hop

1 of 13

htl

1 of 13

IKKβ

1 of 13

IKKε

1 of 13

KP78a

1 of 13

lok

1 of 13

Mekk1

1 of 13

niki

1 of 13

Obsc

1 of 13

otk

1 of 13

Pka-C1

1 of 13

PKD

1 of 13

put

1 of 13

Ret

1 of 13

robo3

1 of 13

sax

1 of 13

Sik2

1 of 13

Sik3

1 of 13

sqa

1 of 13

Src42A

1 of 13

Tcs5

1 of 13

tkv

1 of 13

wit

1 of 13

Human Disease Associations

FlyBase Human Disease Model Reports

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Allele

Disease

Evidence

References

Potential Models Based on Orthology ( 2 )

Human Ortholog

Disease

Evidence

References

DCX; doublecortin

model of X-linked lissencephaly 1

IEA

(FlyBase, 2019-)

STK33; serine/threonine kinase 33

model of spermatogenic failure 93

IEA

(FlyBase, 2019-)

Modifiers Based on Experimental Evidence ( 0 )

Allele

Disease

Interaction

References

Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)

Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.

Homo sapiens (Human)

Gene name

Score

OMIM

OMIM Phenotype

DO term

Complementation?

Transgene?

DCLK2; doublecortin like kinase 2

12 of 14

613166

DCLK1; doublecortin like kinase 1

11 of 14

604742

CAMK4; calcium/calmodulin dependent protein kinase IV

4 of 14

114080

DCLK3; doublecortin like kinase 3

4 of 14

613167

DCX; doublecortin

4 of 14

300121

LISSENCEPHALY, X-LINKED, 1; LISX1

X-linked lissencephaly 1

CAMK1D; calcium/calmodulin dependent protein kinase ID

3 of 14

607957

CAMK1G; calcium/calmodulin dependent protein kinase IG

3 of 14

614994

CAMK1; calcium/calmodulin dependent protein kinase I

3 of 14

604998

CAMKV; CaM kinase like vesicle associated

3 of 14

614993

PNCK; pregnancy up-regulated nonubiquitous CaM kinase

3 of 14

300680

PSKH1; protein serine kinase H1

3 of 14

177015

CHOLESTASIS, PROGRESSIVE FAMILIAL INTRAHEPATIC, 13; PFIC13

PSKH2; protein serine kinase H2

3 of 14

620394

STK33; serine/threonine kinase 33

3 of 14

607670

SPERMATOGENIC FAILURE 93; SPGF93

spermatogenic failure 93

Functional Complementation Data

Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.

Interactions

Summary of Physical Interactions

esyN Network Diagram

Other Interaction Browsers

Summary of Genetic Interactions

esyN Network Diagram

Other Interaction Browsers

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

External Data

Linkouts

BioGRID - A database of protein and genetic interactions.

78259

DroID - A comprehensive database of gene and protein interactions.

FBgn0261387

MIST (protein-protein) - An integrated Molecular Interaction Database

3355134

Pathways

Signaling Pathways (FlyBase)

Metabolic Pathways

FlyBase

External Links

External Data

Linkouts

Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.

SignaLink - A signaling pathway resource with multi-layered regulatory networks.

Q7PLI7

Class of Gene

gene

nuclear_gene

protein_coding_gene

Genomic Location and Detailed Mapping Data

Chromosome (arm)

Recombination map

2-55

Cytogenetic map

41C2-41C2

Sequence location

2R:4,815,426..4,824,319 [-]

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

41C2-41C2

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

41C1-41C6

h46

(Drosophila Heterochromatin Genome Project, 2004)

Experimentally Determined Recombination Data

Location

2-55

(FlyBase, 2016)

2-55.3

(Comeron et al., 2012)

Left of (cM)

Right of (cM)

Notes

Stocks and Reagents

Stocks (7)

Aberrations including deletions of this gene Aberrations including duplications of this gene

Bloomington

26292

y¹ v¹; P{TRiP.JF02061}attP2

42575

y¹ v¹; P{TRiP.HMJ02234}attP40

51404

y¹ sc^* v¹ sev²¹; P{TRiP.GLC01767}attP2

NIG-Fly

HMJ02234

y¹ v¹; P{TRiP.HMJ02234}attP40/CyO

HMJ21522

y¹ v¹; P{TRiP.HMJ21522}attP40/CyO

2RG-0954

y² VhaAC39-1^cho-1 v¹; P{U6-CG17528.NIG.sgRNA}attP40/CyO

VDRC

v342371

P{hsFLP}1, y¹ w¹¹¹⁸; P{HD_CFD02237}attP40/CyO-GFP

Genomic Clones (27)

Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

cDNA Clones (68)

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequenced

BDGP DGC clones

RE56868

Other clones

Drosophila Genomics Resource Center cDNA clones

For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

FBgn0261387

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

Other clones

RNAi and Array Information

Linkouts

DRSC - Results frm RNAi screens

FBgn0261387

Antibody Information

Laboratory Generated Antibodies

Commercially Available Antibodies

Cell Line Information

Publicly Available Cell Lines

Other Stable Cell Lines

Other Comments

One of 42 Drosophila genes identified as being most likely to reveal molecular and cellular mechanisms of nervous system development or plasticity relevant to human Mental Retardation disorders.

(Inlow and Restifo, 2004)

dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R⁺ cell morphology.

(Kiger et al., 2003)

Relationship to Other Genes

Source for database merge of

Additional comments

Source for merge of CG17528 Pk1 was BLAST of GenBank accession U23827 for "Pk1" against the release 5 D.melanogaster genome.

(FlyBase, 1996-)

Identified only as a PCR sequence; identity to other protein kinase encoding genes unknown.

Nomenclature History

Source for database identify of

Nomenclature comments

Etymology

Synonyms and Secondary IDs (7)

Reported As

Symbol Synonym

CAMK-like

(Morrison et al., 2000)

CG17528

(Vien et al., 2024, National Institute of Genetics Fly Stocks, 2023-, Messina et al., 2022, National Institute of Genetics Fly Stocks, 2022-, Bu et al., 2021, Funikov et al., 2020, Wu et al., 2020, Wang et al., 2018, Caizzi et al., 2016, Sopko et al., 2014, Kwon et al., 2013, Di Stefano et al., 2011, Friedman et al., 2011, Ni et al., 2010.12.1, Perkins et al., 2009.3.31, Rossi et al., 2007)

CG40283

(Giot et al., 2003)

PK1

(Winge, 1995.3.31)

Pk1

zyg8

(Vien et al., 2024, Bu et al., 2021)

Name Synonyms

Protein kinase 1

Secondary FlyBase IDs

FBgn0014005
FBgn0032999
FBan0017528
FBgn0058283

Datasets (0)

Study focus (0)

Experimental Role

Project

Project Type

Title

Study result (0)

Result

Result Type

Title

External Crossreferences and Linkouts ( 42 )

Sequence Crossreferences

NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.

3355134

GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.

GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.

RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.

UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.

Q7PLI7

UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information

Q7PLI7

Other crossreferences

AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.

Q7PLI7

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

3355134/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0261387

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0261387

InterPro - A database of protein families, domains and functional sites

KEGG Genes - Molecular building blocks of life in the genomic space.

dme:Dmel_CG17528

MARRVEL_MODEL - MARRVEL (model organism gene)

3355134

Linkouts

BioGRID - A database of protein and genetic interactions.

78259

Cell Signaling Technology - Commercial vendor for primary antibodies and antibody conjugates.

4604

Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones

FBgn0261387

DroID - A comprehensive database of gene and protein interactions.

FBgn0261387

DRSC - Results frm RNAi screens

FBgn0261387

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

CG17528_1

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0032999

FlyCyc Genes - Genes from a BioCyc PGDB for Dmel

FBGN0261387

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG40283

Flygut - An atlas of the Drosophila adult midgut

FBgn0261387

FlyMet - A comprehensive tissue-specific metabolomics resource for Drosophila.

FBgn0261387

iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)

TC016079

MIST (protein-protein) - An integrated Molecular Interaction Database

3355134

Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.

SignaLink - A signaling pathway resource with multi-layered regulatory networks.

Q7PLI7

References (53)

The following external sites may use different assemblies or annotations than FlyBase.

0.01

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