FlyBase Gene Report: Dmel\α-Est5

General Information

Symbol

Dmel\α-Est5

Species

D. melanogaster

Name

α-Esterase-5

Annotation Symbol

CG1089

Feature Type

protein_coding_gene

FlyBase ID

FBgn0261393

Gene Model Status

Current

Stock Availability

10 publicly available

Enzyme Name (EC)

Carboxylesterase (3.1.1.1)

Gene Summary

Contribute a Gene Snapshot for this gene.

All Summaries

Alliance
Auto summary
Gene Group
Red Book
Interactive Fly

Also Known As

αE5, DmαE5, Est-C

Key Links

Genomic Location

Cytogenetic map

84D9-84D5

Sequence location

3R:7,533,496..7,536,390 [-]

Recombination map

3-48

RefSeq locus

NT_033777 REGION:7533496..7536390

Sequence

Get Decorated FASTA

Genomic Maps

JBrowse GBrowse

Help me choose

Other Genome Views

The following external sites may use different assemblies or annotations than FlyBase.

Function

GO Summary Ribbons

Gene Ontology (GO) Annotations (2 terms)

Molecular Function (2 terms)

Terms Based on Experimental Evidence (2 terms)

CV Term

Evidence

References

enables carboxylic ester hydrolase activity

inferred from direct assay

(Birner-Gruenberger et al., 2012, Campbell et al., 2003)

enables serine hydrolase activity

inferred from high throughput direct assay

(Kumar et al., 2021)

Terms Based on Predictions or Assertions (0 terms)

Biological Process (0 terms)

Terms Based on Experimental Evidence (0 terms)

Terms Based on Predictions or Assertions (0 terms)

Cellular Component (0 terms)

Terms Based on Experimental Evidence (0 terms)

Terms Based on Predictions or Assertions (0 terms)

Gene Group (FlyBase)

OTHER CARBOXYLESTERASES

S9 NON-PEPTIDASE HOMOLOGS

Protein Family (UniProt)

Protein Signatures (InterPro)

Catalytic Activity (EC)

Experimental Evidence

A carboxylic ester + H(2)O = an alcohol + a carboxylate (3.1.1.1)

Predictions / Assertions

Summaries

Gene Group (FlyBase)

OTHER CARBOXYLESTERASES -: OTHER CARBOXYLESTERASES are carboxylesterases that do not fall into any other major carboxylesterase group.
S9 NON-PEPTIDASE HOMOLOGS -: S9 non-peptidase homologs are similar in amino acid sequence to S9 serine peptidases but lack one or more of the expected catalytic residues. (Adapted from FBrf0239469.)

Phenotypic Description (Red Book; Lindsley and Zimm 1992)

Est-C

Specifies EST-C (EC 3.1.1.1), the next-to-most rapidly migrating of six anodally migrating esterases detectable with α-napthyl acetate and Fast Blue BB following starch gel electrophoresis. Enzyme a monomer. Putative null alleles homozygous viable, consistent with failure to find lethal complementation group within the interval.

Gene Model and Products

Number of Transcripts

Number of Unique Polypeptides

Please see the JBrowse view of Dmel\α-Est5 for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)

Isoform displayed:

Pfam protein domains

InterPro name

classification

start

end

Protein Domains (via SMART)

Isoform displayed:

SMART protein domains

InterPro name

classification

start

end

Structure New Section

Protein 3D structure (Predicted by AlphaFold) (AlphaFold entry A0A0B4K6V8)

If you don't see the viewer to the right, refresh your browser.

Model Confidence:

Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Comments on Gene Model

Gene model reviewed during 5.49

Sequence Ontology: Class of Gene

gene

nuclear_gene

protein_coding_gene

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Assoc. CDS (aa)

α-Est5-RA

FBtr0081547

NM_079541

1754

542

α-Est5-RB

FBtr0307274

NM_001260036

2490

543

Additional Transcript Data and Comments

Reported size (kB)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kDa)

Length (aa)

Theoretical pI

RefSeq ID

GenBank

α-Est5-PA

FBpp0081071

61.4

542

6.08

NP_524265

AAF54006

α-Est5-PB

FBpp0298275

61.5

543

6.08

NP_001246965

AFH06284

Polypeptides with Identical Sequences

None of the polypeptides share 100% sequence identity.

Additional Polypeptide Data and Comments

Reported size (kDa)

Comments

External Data

Crossreferences

InterPro - A database of protein families, domains and functional sites

Linkouts

Sequences Consistent with the Gene Model

Nucleotide / Polypeptide Records

UniProt

Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\α-Est5 using the Feature Mapper tool.

External Data

Crossreferences

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

alpha-Est5_1

Linkouts

Expression Data

Expression Summary Ribbons

Colored tiles in ribbon indicate that expression data has been curated by FlyBase for that anatomical location. Colorless tiles indicate that there is no curated data for that location.

For complete stage-specific expression data, view the modENCODE Development RNA-Seq section under High-Throughput Expression below.

Transcript Expression

in situ

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage 1 -- 3

organism

Comment: maternally deposited

(Fisher et al., 2012)

embryonic stage 4 -- 6

organism | faint | ubiquitous

(Fisher et al., 2012)

embryonic stage 7 -- 8

organism | faint | ubiquitous

(Fisher et al., 2012)

embryonic stage 13 -- 16

embryonic midgut chamber

(Fisher et al., 2012)

embryonic/larval midgut

(Fisher et al., 2012)

northern blot

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage

organism | intense

(Campbell et al., 2003)

first instar larval stage -- second instar larval stage

organism | faint

(Campbell et al., 2003)

third instar larval stage

organism

(Campbell et al., 2003)

day 1 of adulthood

organism | faint

(Campbell et al., 2003)

adult head | faint

(Campbell et al., 2003)

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Polypeptide Expression

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Evidence

References

Expression Deduced from Reporters

High-Throughput Expression Data

Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\α-Est5 in GBrowse 2

RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region

View exonic expression by developmental stage for Dmel\α-Est5

View exonic expression by tissue for Dmel\α-Est5

Bulk Downloads

RNA-Seq RPKM values for all genes

Reference

See Gelbart and Emmert, 2013 for analysis details and data files for all genes.

Developmental Proteome: Life Cycle

Developmental Proteome: Embryogenesis

External Data and Images

Linkouts

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0261393

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

40905/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0261393

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0015573

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0261393

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG1089

Flygut - An atlas of the Drosophila adult midgut

FBgn0261393

Images

FlyBase Wiki

Image Based Resources

Alleles, Insertions, Transgenic Constructs, and Aberrations

Classical and Insertion Alleles ( 19 )

For All Classical and Insertion Alleles Show

Other relevant insertions

Transgenic Constructs ( 4 )

For All Alleles Carried on Transgenic Constructs Show

Transgenic constructs containing/affecting coding region of α-Est5

Transgenic constructs containing regulatory region of α-Est5

Aberrations (Deficiencies and Duplications) ( 14 )

Inferred from experimentation ( 14 )

Gene not disrupted in

Df(3R)Antp-A41

(Cavener et al., 1986)

Df(3R)Antp-X1

(Cavener et al., 1986)

Df(3R)dsx2D

(Ohnishi and Voelker, 1982)

Df(3R)F76

(Cavener et al., 1986)

Df(3R)Scr

(Cavener et al., 1986, Ohnishi and Voelker, 1982)

Df(3R)Scx2

(Cavener et al., 1986)

Df(3R)Scx4

(Cavener et al., 1986)

Df(3R)Tpl10

(Cavener et al., 1986)

Df(3R)WIN3

(Cavener et al., 1986)

Gene disrupted in

Df(3R)Antp17

(Ohnishi and Voelker, 1982)

Df(3R)D6

(Cavener et al., 1986)

Df(3R)dsx2M

(Cavener et al., 1986)

Df(3R)dsx10M

(Cavener et al., 1986)

Df(3R)dsx29

(Cavener et al., 1986)

Inferred from location ( 0 )

Alleles Representing Disease-Implicated Variants

Phenotypes

For more details about a specific phenotype click on the relevant allele symbol.

Lethality

Allele

viable

viable, with Dcr-2^UAS.cDa, Scer\GAL4^elav.PLu

α-Est5^GD7116

viable, with Scer\GAL4^Mef2.PR

α-Est5^GD7116

viable, with Scer\GAL4^pnr-MD237

α-Est5^GD7116

viable, with Scer\GAL4^tin.CΔ4

α-Est5^GD7116

Other Phenotypes

Allele

electrophoretic variant

Phenotype manifest in

Allele

Orthologs

Downloads

Download All DIOPT Orthologs

Human Orthologs (via DIOPT v8.0)

Homo sapiens (Human) (18)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Hsap\CES1

5 of 15

Yes

Hsap\CES2

5 of 15

Yes

Hsap\CES3

5 of 15

Yes

Hsap\CES4A

5 of 15

Yes

Hsap\CES5A

5 of 15

Yes

4 of 15

3 of 15

3 of 15

3 of 15

3 of 15

3 of 15

3 of 15

3 of 15

2 of 15

Yes

Hsap\NLGN4Y

2 of 15

Hsap\CD74

1 of 15

Yes

Hsap\NID1

1 of 15

Hsap\NID2

1 of 15

Model Organism Orthologs (via DIOPT v8.0)

Mus musculus (laboratory mouse) (33)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Mmus\Ces1a

5 of 15

Yes

Mmus\Ces1b

5 of 15

Yes

Mmus\Ces1c

5 of 15

Yes

Mmus\Ces1d

5 of 15

Yes

Mmus\Ces1e

5 of 15

Yes

Mmus\Ces1g

5 of 15

Yes

Mmus\Ces2a

5 of 15

Yes

Mmus\Ces2b

5 of 15

Yes

Mmus\Ces2e

5 of 15

Yes

Mmus\Ces2f

5 of 15

Yes

Mmus\Ces2g

5 of 15

Yes

Mmus\Ces2h

5 of 15

Yes

Mmus\Ces3a

5 of 15

Yes

Mmus\Ces3b

5 of 15

Yes

Mmus\Ces5a

5 of 15

Yes

4 of 15

4 of 15

4 of 15

4 of 15

4 of 15

3 of 15

3 of 15

3 of 15

3 of 15

3 of 15

2 of 15

1 of 15

1 of 15

Yes

Mmus\Clspn

1 of 15

Mmus\Gm2399

1 of 15

Yes

Mmus\Nid1

1 of 15

Mmus\Nid2

1 of 15

Mmus\Plekhg5

1 of 15

Rattus norvegicus (Norway rat) (37)

Rnor\Ces1a

6 of 13

Yes

Rnor\Ces1f

6 of 13

Yes

Rnor\Ces2g

6 of 13

Yes

Rnor\Ces2h

6 of 13

Yes

Rnor\Ces4a

6 of 13

Yes

Rnor\Ces5a

6 of 13

Yes

Rnor\Ces1c

5 of 13

Rnor\Ces1d

5 of 13

Yes

5 of 13

4 of 13

4 of 13

4 of 13

4 of 13

Yes

Rnor\LOC679149

4 of 13

Rnor\LOC100910040

4 of 13

Yes

3 of 13

3 of 13

3 of 13

3 of 13

3 of 13

3 of 13

3 of 13

Yes

Rnor\Ache

2 of 13

Rnor\Ces3a

2 of 13

Yes

Rnor\Cesl1

2 of 13

Rnor\LOC688542

2 of 13

Yes

Rnor\LOC102548129

2 of 13

Yes

Rnor\Nlgn1

2 of 13

Rnor\Cd74

1 of 13

Yes

Rnor\LOC291863

1 of 13

Yes

Rnor\LOC679356

1 of 13

Yes

Rnor\LOC679368

1 of 13

Yes

Rnor\LOC100365112

1 of 13

Yes

Rnor\LOC102557406

1 of 13

Yes

Rnor\LOC108348093

1 of 13

Yes

Rnor\Nid1

1 of 13

Rnor\Nid2

1 of 13

Xenopus tropicalis (Western clawed frog) (22)

Xtro\ache

4 of 12

Yes

Xtro\ces2

4 of 12

Yes

Xtro\ces3

4 of 12

Yes

Xtro\LOC100494782

4 of 12

Yes

3 of 12

3 of 12

3 of 12

3 of 12

3 of 12

3 of 12

Yes

Xtro\bche

2 of 12

Xtro\ces1

2 of 12

Yes

Xtro\ces5a

2 of 12

Yes

Xtro\LOC100493652

2 of 12

Yes

Xtro\LOC100493819

2 of 12

Yes

Xtro\LOC100493994

2 of 12

Yes

Xtro\LOC100494295

2 of 12

Yes

Xtro\cd74

1 of 12

Yes

Xtro\LOC100492444

1 of 12

Yes

Xtro\nid1

1 of 12

Xtro\nid2

1 of 12

Xtro\nlgn1

1 of 12

Danio rerio (Zebrafish) (21)

Drer\ces2

5 of 15

Yes

Drer\ces3

5 of 15

Yes

Drer\ache

4 of 15

Drer\LOC100334697

4 of 15

Drer\si:dkey-30c15.17

4 of 15

Yes

3 of 15

3 of 15

3 of 15

3 of 15

3 of 15

3 of 15

3 of 15

3 of 15

3 of 15

3 of 15

3 of 15

3 of 15

Yes

Drer\cd74a

1 of 15

Yes

Drer\nid1a

1 of 15

Drer\nid2a

1 of 15

Drer\si:dkey-193c22.1

1 of 15

Caenorhabditis elegans (Nematode, roundworm) (47)

Cele\F07C4.12

9 of 15

Yes

Cele\F15A8.6

8 of 15

Cele\F56C11.6

8 of 15

Yes

Cele\K11G9.3

8 of 15

Yes

Cele\Y71H2AM.13

8 of 15

Yes

Cele\C52A10.1

7 of 15

Yes

Cele\F13H6.3

7 of 15

Yes

Cele\K11G9.2

7 of 15

Yes

Cele\B0238.7

6 of 15

Yes

6 of 15

6 of 15

5 of 15

5 of 15

5 of 15

4 of 15

4 of 15

4 of 15

4 of 15

4 of 15

Yes

4 of 15

4 of 15

4 of 15

4 of 15

4 of 15

4 of 15

4 of 15

4 of 15

4 of 15

4 of 15

4 of 15

4 of 15

3 of 15

3 of 15

3 of 15

3 of 15

3 of 15

3 of 15

3 of 15

3 of 15

3 of 15

2 of 15

2 of 15

2 of 15

2 of 15

1 of 15

1 of 15

1 of 15

Yes

Arabidopsis thaliana (thale-cress) (18)

Atha\AT1G19190

1 of 9

Yes

Atha\AT1G47480

1 of 9

Yes

Atha\AT1G49640

1 of 9

Yes

Atha\AT1G49650

1 of 9

Yes

Atha\AT1G68620

1 of 9

Yes

Atha\AT2G03550

1 of 9

Yes

Atha\AT2G45600

1 of 9

Yes

Atha\AT2G45610

1 of 9

Yes

Atha\AT5G06570

1 of 9

Yes

Atha\CXE5

1 of 9

Yes

Atha\CXE12

1 of 9

Yes

Atha\CXE13

1 of 9

Yes

Atha\CXE17

1 of 9

Yes

Atha\CXE18

1 of 9

Yes

Atha\CXE20

1 of 9

Yes

Atha\GID1A

1 of 9

Yes

Atha\GID1B

1 of 9

Yes

Atha\GID1C

1 of 9

Yes

Saccharomyces cerevisiae (Brewer's yeast) (0)

No records found.

Schizosaccharomyces pombe (Fission yeast) (1)

Spom\SPCC417.12

3 of 12

Yes

Other Organism Orthologs (via OrthoDB)

Paralogs

Downloads

Download All DIOPT Paralogs

Paralogs (via DIOPT v8.0)

Drosophila melanogaster (Fruit fly) (36)

Gene Symbol

Score

Source

Alignment

7 of 10

7 of 10

7 of 10

7 of 10

7 of 10

7 of 10

gas

7 of 10

6 of 10

6 of 10

6 of 10

6 of 10

5 of 10

5 of 10

5 of 10

5 of 10

5 of 10

5 of 10

5 of 10

Glt

5 of 10

Jhedup

5 of 10

Jhe

5 of 10

Ace

4 of 10

CG6414

4 of 10

CG10175

4 of 10

clt

4 of 10

CG5397

3 of 10

CG10339

3 of 10

CG12869

3 of 10

Gli

3 of 10

Nlg3

3 of 10

Nrt

3 of 10

2 of 10

2 of 10

2 of 10

1 of 10

Ndg

1 of 10

Human Disease Associations

FlyBase Human Disease Model Reports

Disease Model Summary Ribbon

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Allele

Disease

Evidence

References

Potential Models Based on Orthology ( 0 )

Human Ortholog

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Allele

Disease

Interaction

References

Disease Associations of Human Orthologs (via DIOPT v8.0 and OMIM)

Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.

Homo sapiens (Human)

Gene name

Score

OMIM

OMIM Phenotype

DO term

Complementation?

Transgene?

CES1; carboxylesterase 1

5 of 15

114835

DRUG METABOLISM, ALTERED, CES1-RELATED

CES2; carboxylesterase 2

5 of 15

605278

CES3; carboxylesterase 3

5 of 15

605279

CES4A; carboxylesterase 4A

5 of 15

CES5A; carboxylesterase 5A

5 of 15

618678

ACHE; acetylcholinesterase (Cartwright blood group)

4 of 15

100740

YT BLOOD GROUP ANTIGEN

BCHE; butyrylcholinesterase

3 of 15

177400

BUTYRYLCHOLINESTERASE DEFICIENCY; BCHED

CEL; carboxyl ester lipase

3 of 15

114840

MATURITY-ONSET DIABETES OF THE YOUNG, TYPE 8, WITH EXOCRINE DYSFUNCTION; MODY8

maturity-onset diabetes of the young type 8

NLGN1; neuroligin 1

3 of 15

600568

AUTISM, SUSCEPTIBILITY TO, 20; AUTS20

3 of 15

3 of 15

NLGN4X; neuroligin 4 X-linked

3 of 15

300427

TG; thyroglobulin

3 of 15

188450

thyroid dyshormonogenesis 3

Functional Complementation Data

Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.

Interactions

Summary of Physical Interactions

esyN Network Diagram

Interactions Browser

View in Interactions Browser

Please see the Physical Interaction reports below for full details

protein-protein

Physical Interaction

Assay

References

α-Est5 - CG7737

experimental knowledge based

(Guruharsha et al., 2011)

α-Est5 - HIP-R

experimental knowledge based

(Guruharsha et al., 2011)

Summary of Genetic Interactions

esyN Network Diagram

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

External Data

Linkouts

DroID - A comprehensive database of gene and protein interactions.

FBgn0261393

MIST (protein-protein) - An integrated Molecular Interaction Database

alpha-Est5

Pathways

Signaling Pathways (FlyBase)

Metabolic Pathways

External Data

Linkouts

Genomic Location and Detailed Mapping Data

Chromosome (arm)

Recombination map

3-48

Cytogenetic map

84D9-84D5

Sequence location

3R:7,533,496..7,536,390 [-]

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

84D9-84D5

Limits computationally determined from genome sequence between P{EP}EP3060^EP3060 and P{PZ}grn⁰⁵⁹³⁰; Left limit from complementation mapping relative to rn (citation unavailable) Right limit from non-inclusion within Df(3R)D7 (citation unavailable)

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

84D3-84D10

(Robin, 1996.3.11)

84D3-84D10

(determined by in situ hybridisation)

(Russell et al., 1996)

84D3-84E2

(determined by in situ hybridisation)

(Oakeshott et al., 1993)

Experimentally Determined Recombination Data

Location

3-48

(FlyBase, 2016)

3-44.3

(Comeron et al., 2012)

(Robin, 1996.3.11, Choudhary et al., 1992)

3-47.7

(Ohnishi and Voelker, 1982)

Left of (cM)

(Ohnishi and Voelker, 1982, Ohnishi and Voelker, 1979)

Right of (cM)

Notes

The distance between Est-C and Fdh is estimated to be 0.0058 +/- 0.0022.

(Mukai and Voelker, 1977)

Stocks and Reagents

Stocks (10)

Aberrations including deletions of this gene Aberrations including duplications of this gene

Bloomington

4211

Est-6⁰ α-Est5ⁿ

4017

α-Est5^nGB1/TM6, α-Est5^S

13193

y¹ w^67c23; P{SUPor-P}α-Est5^KG01079 ry⁵⁰⁶

4016

Est-6^S α-Est5^F Fdh^S Lap-D^F Acph-1^A Tpi⁶/TM6, Est-6^F α-Est5^S Fdh^F Lap-D^S Acph-1^B Tpi⁴

Kyoto

101636

α-Est5^VF

101637

α-Est5^NC2 / TM3, Sb¹ Ser¹

107556

Est-6^S α-Est5^F Fdh^S Lap-D^F Acph-1^A Tpi⁶/TM6, Est-6^F α-Est5^S Fdh^F Lap-D^S Acph-1^B Tpi⁴

VDRC

v100526

P{KK106201}VIE-260B

v27332

w¹¹¹⁸; P{GD7116}v27332

v318071

PBac{fTRG00181.sfGFP-TVPTBF}VK00033

Genomic Clones (17)

Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

cDNA Clones (10)

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequenced

BDGP DGC clones

GH12017

Other clones

DPiM_GH12017

Drosophila Genomics Resource Center cDNA clones

For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

FBgn0261393

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

Other clones

RNAi and Array Information

Linkouts

DRSC - Results frm RNAi screens

FBgn0261393

GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents

40905

Antibody Information

Laboratory Generated Antibodies

Commercially Available Antibodies

Other Information

Relationship to Other Genes

Source for database identify of

Source for identity of: α-Est5 CG1089

(Zhong, 1999.11)

Source for database merge of

Source for merge of: α-Est5 Est-C

(Campbell et al., 2003)

Additional comments

Other Comments

Eleven putative esterase genes from the region containing the α-esterase cluster are cloned.

(Russell et al., 1996)

Corresponds to Est-9 of FBrf0053202.

(Oakeshott et al., 1993)

Gramoxone has no mutagenic effect on the genetic background of Est-C.

(el Abidin Salam et al., 1993)

No difference in allele fixed in lines selected over 700 generations for high (negative) and low (positive) geotaxis.

(Stoltenberg et al., 1992)

Presumably one of α-Est1 to α-Est10, but precise relationship not determined.

(Healy et al., 1991)

Protein product identified as EST9 isozyme.

(Healy et al., 1991)

Allelic frequencies have been determined between European and African populations. African populations show a greater genetic diversity, as measured by the number of alleles found. Within each geographic group there is a homogeneity of allele frequencies.

(David, 1982)

No linkage disequilibrium has been detected between Gpdh, Mdh1, Adh, Hex-C, Est-C or Fdh.

(Mukai and Voelker, 1977)

Specifies EST-C, the next-to-most rapidly migrating of six anodally migrating esterases detectable with α-napthyl acetate and Fast Blue BB following starch gel electrophoresis. Enzyme a monomer. Putative null alleles homozygous viable, consistent with failure to find lethal complementation group within the interval.

Origin and Etymology

Discoverer

Etymology

Identification

External Crossreferences and Linkouts ( 44 )

Sequence Crossreferences

NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.

40905

GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.

GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.

RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.

UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.

A0A0B4K6V8

UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information

Other crossreferences

AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.