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Gene Dmel\didum

General Information
Symbol	Dmel\didum	Species	D. melanogaster
Name	dilute class unconventional myosin	Annotation symbol	CG2146
Feature type	protein_coding_gene	FlyBase ID	FBgn0261397
Gene Model Status	Current	Stock availability	4 publicly available
Also Known As	MyoV, DmV
Genomic Location
Chromosome (arm)	2R	Recombination map
Cytogenetic map	43C7-43D1	Sequence location	2R:3,387,652..3,396,130 [+]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents Beta	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene dilute class unconventional myosin is referred to in FlyBase by the symbol Dmel\didum (CG2146, FBgn0261397). It is a protein_coding_gene from Drosophila melanogaster. There is experimental evidence that it has the molecular function: actin binding; actin-dependent ATPase activity; ATP binding; calmodulin binding; myosin light chain binding. There is experimental evidence that it is involved in the biological process: positive regulation of pole plasm oskar mRNA localization; mitochondrion transport along microtubule; sperm individualization; rhabdomere development; actin filament-based movement; anterior/posterior axis specification, embryo. 18 alleles are reported. The phenotypes of these alleles are annotated with: male genitalia; spermatid cyst; spermatozoon. It has 3 annotated transcripts and 3 annotated polypeptides. Protein features are: Dil domain; Dilute; IQ motif, EF-hand binding site; Myosin head, motor domain. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of low expression. Peak expression observed within 00-06 hour embryonic stages, at stages throughout the pupal period, in stages of adults of both sexes. Summary of FlyAtlas Anatomical Expression Data: Many larval and adult organs/tissues expressed at moderate levels. Expression at high levels in the following post-embryonic organs or tissues: adult eye, larval/adult salivary gland. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, larval/adult central nervous system, adult crop, larval/adult midgut, larval/adult hindgut, larval/adult Malpighian tubules, larval trachea, adult female reproductive system, adult male accessory gland, larval carcass. Comments on Affy2 ProbeSet: ProbeSet 1635040_a_at completely aligns to an exonic region of only a subset of 2 of the 3 FlyBase-annotated transcript isoforms of didum. Gene sequence location is 2R:3387652..3396130.
User Contributed Data
	Beta version, feedback welcome
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2013_03
FB2013_02	Controlled Vocabulary Terms Cul2-RING ubiquitin ligase complex positive regulation of stress-activated MAPK cascade
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 43C7-43D1   Limits computationally determined from genome sequence between P{lacW}cosk16101 and P{EP}CG1600EP398
Experimentally Determined Cytological Location
Cytogenetic map Notes References 43B-43B     (Maciver, 1996.9.17) 43C-43D     (Bonafe, 1997.5.12) 43B-43C   (determined by in situ hybridisation)   (MacIver et al., 1998) 43C-43D   (determined by in situ hybridisation)   (Bonafe and Sellers, 1998) 43B-43C   (determined by in situ hybridisation)   (McCormack et al., 1996)
Experimentally Determined Recombination Data
Location	2- (Luschnig et al., 2004, McCormack et al., 1996)
Left of (cM)	c (Krauss et al., 2009)
Right of (cM)
Notes	Maps to 2R. (Luschnig et al., 2004)
Gene Model & Products
Please see the GBrowse view of Dmel\didum for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
	Gene model reviewed during 5.48
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) didum-RA FBtr0089745  NM_057838   6478   1792 didum-RB FBtr0089744  NM_165536   5992   1196 didum-RC FBtr0089743  NM_165535   6114   1800
Additional Transcript Data & Comments
Reported size (kB)	6.5 (northern blot) (MacIver et al., 1998) 6.0 (northern blot) (Bonafe and Sellers, 1998)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein didum-PA   FBpp0088686   207.3   1792   8.52     NP_477186   AAF59241 didum-PB   FBpp0088685   137.9   1196   9.45     NP_724570   AAM68903 didum-PC   FBpp0088684   208.2   1800   8.60     NP_724569   AAM68902
Additional Polypeptide Data & Comments
Reported size (kDa)	1792 (aa); 207 (kD predicted) (Bonafe and Sellers, 1998)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • P-loop containing nucleoside triphosphate hydrolase (IPR027417) IQ motif, EF-hand binding site (IPR000048) Myosin head, motor domain (IPR001609) Dilute (IPR002710) Dil domain (IPR018444)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA941590   AE013599 AAF59241   AE013599 AAM68902   AE013599 AAM68903   AC004280   AF003826 AAC99496   AI064168   AI403143   AI945561   AX093905   BE977946   BF485763   BF486085   BF486222   BF486282   BF486962   BF487278   BF488104   BF490245   BF490470   BF490647   BF492262   BF492402   BF492770   BF492771   BF497807   BF501449   BF502827   BF504794   BG632162   BG634051   BG634512   BH840533   BI234491   BT010003 AAQ22472   CK132863   CO189902   CO191037   CO275243   CO276632   CO278241   CO279613   CO290147   CO297527   CO302902   CO340333   EC051268   EC052814   EC053294   EC055168   EC079127   EC207052   EC211825   EC224295   EC232197   EC233125   EC241288   EC245753   EC260317   GH948546   GH951020   GH965219   GH971415   GH980631   GH982312   GH984396   Y08160 CAA69352
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL	A1Z700 A1Z6Z9 A1Z6Z8 O97417 Q94882 Q7YU40
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
northern blot Stage Tissue/Position (including subcellular localization) Reference embryonic stage     (MacIver et al., 1998) embryonic stage & adult stage     (Bonafe and Sellers, 1998) embryonic stage 1 -- 6   organism | ubiquitous   (Bonafe and Sellers, 1998) embryonic stage 16   embryonic/larval hindgut   (Bonafe and Sellers, 1998) adult stage | male   testis   (MacIver et al., 1998) adult stage | female   ovary   (MacIver et al., 1998) adult stage & oogenesis   oocyte   (MacIver et al., 1998) adult stageoogenesis stage S6 -- S8   oocyte | anterior   (MacIver et al., 1998) adult stageoogenesis stage S10 -- S14   nurse cell   (MacIver et al., 1998)
Additional Descriptive Data
	didum transcripts are detected in embryos and adults on northern blots. Maternally derived transcripts are uniformly distributed in embryos up to stage 6. Later in embryogenesis, high levels of didum transcript are observed in the ectodermal tissue of the hindgut. (Bonafe and Sellers, 1998) didum transcripts are detected in adult ovaries and testes and at low levels in embryos by northern blots. They are detected by in situ hybridization in ovaries. They are localized to the oocyte from germarial stage 2 and are confined to the anterior margin of the oocyte during the middle stages of oogenesis (6-8). In late vitellogenic stages (9-11), there is strong staining in nurse cells and a loss of anterior localization in the oocyte. (MacIver et al., 1998)
Marker for
Subcellular Localization
CV Term
Polypeptide Expression
Additional Descriptive Data
Marker for
Subcellular Localization (GO Cellular Component)
CV term Evidence References
myosin V complex inferred from physical interaction with Cam (Martin and Bayley, 2004) inferred from physical interaction with Mlc-c (Franke et al., 2006)
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools
Reference	See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes.
FlyAtlas Anatomy Microarray
FlyAtlas Anatomical Expression Data (FlyAtlas-RNA.adult) (FlyAtlas-RNA.larva)    Styles Linear Logarithmic Heatmap Back-to-back    Scales gene max expression Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Many larval and adult organs/tissues expressed at moderate levels. Expression at high levels in the following post-embryonic organs or tissues: adult eye, larval/adult salivary gland. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, larval/adult central nervous system, adult crop, larval/adult midgut, larval/adult hindgut, larval/adult Malpighian tubules, larval trachea, adult female reproductive system, adult male accessory gland, larval carcass. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (>999.999) Linear, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    114.275 Larval Midgut    290.8 Larval Hindgut    255.3 Larval Malpighian Tubules    261.4 Larval Fat Body    73.5 Larval Salivary Gland    742.3 Larval Trachea    108.5 Larval Carcass    112.875 Adult Head    255 Adult Eye    934.25 Adult Brain    292.6 Adult Thoracic-Abdominal Ganglion    293 Adult Crop    225.9 Adult Midgut    314.2 Adult Hindgut    239.9 Adult Malpighian Tubules    326 Adult Fat Body    68.4 Adult Salivary Gland    670.7 Adult Heart    44.375 Adult VirginFemale Spermatheca    115.8 Adult InseminatedFemale Spermatheca    137.2 Adult Ovary    416.7 Adult Testis    38.2 Adult Male Accessory Gland    314.4 Adult Carcass    81.6 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    114.275 Larval Midgut    290.8 Larval Hindgut    255.3 Larval Malpighian Tubules    261.4 Larval Fat Body    73.5 Larval Salivary Gland  (742.3) Larval Trachea    108.5 Larval Carcass    112.875 Adult Head    255 Adult Eye  (934.25) Adult Brain    292.6 Adult Thoracic-Abdominal Ganglion    293 Adult Crop    225.9 Adult Midgut    314.2 Adult Hindgut    239.9 Adult Malpighian Tubules    326 Adult Fat Body    68.4 Adult Salivary Gland  (670.7) Adult Heart    44.375 Adult VirginFemale Spermatheca    115.8 Adult InseminatedFemale Spermatheca    137.2 Adult Ovary    416.7 Adult Testis    38.2 Adult Male Accessory Gland    314.4 Adult Carcass    81.6 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    114.275 Larval Midgut    290.8 Larval Hindgut    255.3 Larval Malpighian Tubules    261.4 Larval Fat Body    73.5 Larval Salivary Gland    742.3 Larval Trachea    108.5 Larval Carcass    112.875 Adult Head    255 Adult Eye    934.25 Adult Brain    292.6 Adult Thoracic-Abdominal Ganglion    293 Adult Crop    225.9 Adult Midgut    314.2 Adult Hindgut    239.9 Adult Malpighian Tubules    326 Adult Fat Body    68.4 Adult Salivary Gland    670.7 Adult Heart    44.375 Adult VirginFemale Spermatheca    115.8 Adult InseminatedFemale Spermatheca    137.2 Adult Ovary    416.7 Adult Testis    38.2 Adult Male Accessory Gland    314.4 Adult Carcass    81.6 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    114.275 Larval Midgut    290.8 Larval Hindgut    255.3 Larval Malpighian Tubules    261.4 Larval Fat Body    73.5 Larval Salivary Gland    742.3 Larval Trachea    108.5 Larval Carcass    112.875 Adult Head    255 Adult Eye    934.25 Adult Brain    292.6 Adult Thoracic-Abdominal Ganglion    293 Adult Crop    225.9 Adult Midgut    314.2 Adult Hindgut    239.9 Adult Malpighian Tubules    326 Adult Fat Body    68.4 Adult Salivary Gland    670.7 Adult Heart    44.375 Adult VirginFemale Spermatheca    115.8 Adult InseminatedFemale Spermatheca    137.2 Adult Ovary    416.7 Adult Testis    38.2 Adult Male Accessory Gland    314.4 Adult Carcass    81.6 Expression Level Scale  Very high  log, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    114.275 Larval Midgut    290.8 Larval Hindgut    255.3 Larval Malpighian Tubules    261.4 Larval Fat Body    73.5 Larval Salivary Gland    742.3 Larval Trachea    108.5 Larval Carcass    112.875 Adult Head    255 Adult Eye    934.25 Adult Brain    292.6 Adult Thoracic-Abdominal Ganglion    293 Adult Crop    225.9 Adult Midgut    314.2 Adult Hindgut    239.9 Adult Malpighian Tubules    326 Adult Fat Body    68.4 Adult Salivary Gland    670.7 Adult Heart    44.375 Adult VirginFemale Spermatheca    115.8 Adult InseminatedFemale Spermatheca    137.2 Adult Ovary    416.7 Adult Testis    38.2 Adult Male Accessory Gland    314.4 Adult Carcass    81.6 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    114.275 Larval Midgut    290.8 Larval Hindgut    255.3 Larval Malpighian Tubules    261.4 Larval Fat Body    73.5 Larval Salivary Gland  742.3 Larval Trachea    108.5 Larval Carcass    112.875 Adult Head    255 Adult Eye  (934.25) Adult Brain    292.6 Adult Thoracic-Abdominal Ganglion    293 Adult Crop    225.9 Adult Midgut    314.2 Adult Hindgut    239.9 Adult Malpighian Tubules    326 Adult Fat Body    68.4 Adult Salivary Gland  670.7 Adult Heart    44.375 Adult VirginFemale Spermatheca    115.8 Adult InseminatedFemale Spermatheca    137.2 Adult Ovary    416.7 Adult Testis    38.2 Adult Male Accessory Gland    314.4 Adult Carcass    81.6 Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    114.275 Larval Midgut    290.8 Larval Hindgut    255.3 Larval Malpighian Tubules    261.4 Larval Fat Body    73.5 Larval Salivary Gland    742.3 Larval Trachea    108.5 Larval Carcass    112.875 Adult Head    255 Adult Eye    934.25 Adult Brain    292.6 Adult Thoracic-Abdominal Ganglion    293 Adult Crop    225.9 Adult Midgut    314.2 Adult Hindgut    239.9 Adult Malpighian Tubules    326 Adult Fat Body    68.4 Adult Salivary Gland    670.7 Adult Heart    44.375 Adult VirginFemale Spermatheca    115.8 Adult InseminatedFemale Spermatheca    137.2 Adult Ovary    416.7 Adult Testis    38.2 Adult Male Accessory Gland    314.4 Adult Carcass    81.6 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    114.275 Larval Midgut    290.8 Larval Hindgut    255.3 Larval Malpighian Tubules    261.4 Larval Fat Body    73.5 Larval Salivary Gland    742.3 Larval Trachea    108.5 Larval Carcass    112.875 Adult Head    255 Adult Eye    934.25 Adult Brain    292.6 Adult Thoracic-Abdominal Ganglion    293 Adult Crop    225.9 Adult Midgut    314.2 Adult Hindgut    239.9 Adult Malpighian Tubules    326 Adult Fat Body    68.4 Adult Salivary Gland    670.7 Adult Heart    44.375 Adult VirginFemale Spermatheca    115.8 Adult InseminatedFemale Spermatheca    137.2 Adult Ovary    416.7 Adult Testis    38.2 Adult Male Accessory Gland    314.4 Adult Carcass    81.6 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    255   NA  Eye    934.25   NA  Brain    292.6   114.275  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    293   NA  Crop    225.9   290.8  Midgut    314.2   255.3  Hindgut    239.9   261.4  Malpighian Tubules    326   73.5  Fat Body    68.4   742.3  Salivary Gland    670.7   NA  Heart    44.375   108.5  Trachea    NA   NA  VirginFemale Spermatheca    115.8   NA  InseminatedFemale Spermatheca    137.2   NA  Ovary    416.7   NA  Testis    38.2   NA  Male Accessory Gland    314.4   112.875  Carcass    81.6 FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
modENCODE Anatomy RNA-Seq
modENCODE Tissue Expression Data (modENCODE_mRNA-Seq_tissues)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    31 central nervous system, larvae L3    10 central nervous system, pupae P8    15 head, virgin 1-day female    22 head, virgin 4-day female    21 head, virgin 20-day female    18 head, mated 1-day female    20 head, mated 4-day female    22 head, mated 20-day female    14 head, mated 1-day male    30 head, mated 4-day male    33 head, mated 20-day male    36 salivary gland, larvae L3 wandering    5 salivary gland, white prepupae    12 digestive system, larvae L3 wandering    15 digestive system, 1-day adult    15 digestive system, 4-day adult    20 digestive system, 20-day adult    18 fat body, larvae L3 wandering    3 fat body, white prepupae    10 fat body, pupae P8    12 carcass, larvae L3 wandering    11 carcass, 1-day adult    8 carcass, 4-day adult    13 carcass, 20-day adult    8 ovary, virgin 4-day female    70 ovary, mated 4-day female    65 testis, mated 4-day male    61 accessory gland, mated 4-day male    13 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  Linear, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering  (31) central nervous system, larvae L3    10 central nervous system, pupae P8    15 head, virgin 1-day female    22 head, virgin 4-day female    21 head, virgin 20-day female    18 head, mated 1-day female    20 head, mated 4-day female    22 head, mated 20-day female    14 head, mated 1-day male  (30) head, mated 4-day male  (33) head, mated 20-day male  (36) salivary gland, larvae L3 wandering    5 salivary gland, white prepupae    12 digestive system, larvae L3 wandering    15 digestive system, 1-day adult    15 digestive system, 4-day adult    20 digestive system, 20-day adult    18 fat body, larvae L3 wandering    3 fat body, white prepupae    10 fat body, pupae P8    12 carcass, larvae L3 wandering    11 carcass, 1-day adult    8 carcass, 4-day adult    13 carcass, 20-day adult    8 ovary, virgin 4-day female  (70) ovary, mated 4-day female  (65) testis, mated 4-day male  (61) accessory gland, mated 4-day male    13 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    31 central nervous system, larvae L3    10 central nervous system, pupae P8    15 head, virgin 1-day female    22 head, virgin 4-day female    21 head, virgin 20-day female    18 head, mated 1-day female    20 head, mated 4-day female    22 head, mated 20-day female    14 head, mated 1-day male    30 head, mated 4-day male    33 head, mated 20-day male    36 salivary gland, larvae L3 wandering    5 salivary gland, white prepupae    12 digestive system, larvae L3 wandering    15 digestive system, 1-day adult    15 digestive system, 4-day adult    20 digestive system, 20-day adult    18 fat body, larvae L3 wandering    3 fat body, white prepupae    10 fat body, pupae P8    12 carcass, larvae L3 wandering    11 carcass, 1-day adult    8 carcass, 4-day adult    13 carcass, 20-day adult    8 ovary, virgin 4-day female    70 ovary, mated 4-day female    65 testis, mated 4-day male    61 accessory gland, mated 4-day male    13 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    31 central nervous system, larvae L3    10 central nervous system, pupae P8    15 head, virgin 1-day female    22 head, virgin 4-day female    21 head, virgin 20-day female    18 head, mated 1-day female    20 head, mated 4-day female    22 head, mated 20-day female    14 head, mated 1-day male    30 head, mated 4-day male    33 head, mated 20-day male    36 salivary gland, larvae L3 wandering    5 salivary gland, white prepupae    12 digestive system, larvae L3 wandering    15 digestive system, 1-day adult    15 digestive system, 4-day adult    20 digestive system, 20-day adult    18 fat body, larvae L3 wandering    3 fat body, white prepupae    10 fat body, pupae P8    12 carcass, larvae L3 wandering    11 carcass, 1-day adult    8 carcass, 4-day adult    13 carcass, 20-day adult    8 ovary, virgin 4-day female    70 ovary, mated 4-day female    65 testis, mated 4-day male    61 accessory gland, mated 4-day male    13 Expression Level Scale  Extremely high  log, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    31 central nervous system, larvae L3    10 central nervous system, pupae P8    15 head, virgin 1-day female    22 head, virgin 4-day female    21 head, virgin 20-day female    18 head, mated 1-day female    20 head, mated 4-day female    22 head, mated 20-day female    14 head, mated 1-day male    30 head, mated 4-day male    33 head, mated 20-day male    36 salivary gland, larvae L3 wandering    5 salivary gland, white prepupae    12 digestive system, larvae L3 wandering    15 digestive system, 1-day adult    15 digestive system, 4-day adult    20 digestive system, 20-day adult    18 fat body, larvae L3 wandering    3 fat body, white prepupae    10 fat body, pupae P8    12 carcass, larvae L3 wandering    11 carcass, 1-day adult    8 carcass, 4-day adult    13 carcass, 20-day adult    8 ovary, virgin 4-day female    70 ovary, mated 4-day female    65 testis, mated 4-day male    61 accessory gland, mated 4-day male    13 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering  31 central nervous system, larvae L3    10 central nervous system, pupae P8    15 head, virgin 1-day female    22 head, virgin 4-day female    21 head, virgin 20-day female    18 head, mated 1-day female    20 head, mated 4-day female    22 head, mated 20-day female    14 head, mated 1-day male  30 head, mated 4-day male  (33) head, mated 20-day male  (36) salivary gland, larvae L3 wandering    5 salivary gland, white prepupae    12 digestive system, larvae L3 wandering    15 digestive system, 1-day adult    15 digestive system, 4-day adult    20 digestive system, 20-day adult    18 fat body, larvae L3 wandering    3 fat body, white prepupae    10 fat body, pupae P8    12 carcass, larvae L3 wandering    11 carcass, 1-day adult    8 carcass, 4-day adult    13 carcass, 20-day adult    8 ovary, virgin 4-day female  (70) ovary, mated 4-day female  (65) testis, mated 4-day male  (61) accessory gland, mated 4-day male    13 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    31 central nervous system, larvae L3    10 central nervous system, pupae P8    15 head, virgin 1-day female    22 head, virgin 4-day female    21 head, virgin 20-day female    18 head, mated 1-day female    20 head, mated 4-day female    22 head, mated 20-day female    14 head, mated 1-day male    30 head, mated 4-day male    33 head, mated 20-day male    36 salivary gland, larvae L3 wandering    5 salivary gland, white prepupae    12 digestive system, larvae L3 wandering    15 digestive system, 1-day adult    15 digestive system, 4-day adult    20 digestive system, 20-day adult    18 fat body, larvae L3 wandering    3 fat body, white prepupae    10 fat body, pupae P8    12 carcass, larvae L3 wandering    11 carcass, 1-day adult    8 carcass, 4-day adult    13 carcass, 20-day adult    8 ovary, virgin 4-day female    70 ovary, mated 4-day female    65 testis, mated 4-day male    61 accessory gland, mated 4-day male    13 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    31 central nervous system, larvae L3    10 central nervous system, pupae P8    15 head, virgin 1-day female    22 head, virgin 4-day female    21 head, virgin 20-day female    18 head, mated 1-day female    20 head, mated 4-day female    22 head, mated 20-day female    14 head, mated 1-day male    30 head, mated 4-day male    33 head, mated 20-day male    36 salivary gland, larvae L3 wandering    5 salivary gland, white prepupae    12 digestive system, larvae L3 wandering    15 digestive system, 1-day adult    15 digestive system, 4-day adult    20 digestive system, 20-day adult    18 fat body, larvae L3 wandering    3 fat body, white prepupae    10 fat body, pupae P8    12 carcass, larvae L3 wandering    11 carcass, 1-day adult    8 carcass, 4-day adult    13 carcass, 20-day adult    8 ovary, virgin 4-day female    70 ovary, mated 4-day female    65 testis, mated 4-day male    61 accessory gland, mated 4-day male    13 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Tissue   Expression Level imaginal disc, larvae L3 wandering     central nervous system, larvae L3     central nervous system, pupae P8     head, virgin 1-day female     head, virgin 4-day female     head, virgin 20-day female     head, mated 1-day female     head, mated 4-day female     head, mated 20-day female     head, mated 1-day male     head, mated 4-day male     head, mated 20-day male     salivary gland, larvae L3 wandering     salivary gland, white prepupae     digestive system, larvae L3 wandering     digestive system, 1-day adult     digestive system, 4-day adult     digestive system, 20-day adult     fat body, larvae L3 wandering     fat body, white prepupae     fat body, pupae P8     carcass, larvae L3 wandering     carcass, 1-day adult     carcass, 4-day adult     carcass, 20-day adult     ovary, virgin 4-day female     ovary, mated 4-day female     testis, mated 4-day male     accessory gland, mated 4-day male
modENCODE Development RNA-Seq
modENCODE Temporal Expression Data (modENCODE_mRNA-Seq_U)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of low expression. Peak expression observed within 00-06 hour embryonic stages, at stages throughout the pupal period, in stages of adults of both sexes. [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    38 embryo 02-04hr    5 embryo 04-06hr    5 embryo 06-08hr    4 embryo 08-10hr    4 embryo 10-12hr    3 embryo 12-14hr    5 embryo 14-16hr    5 embryo 16-18hr    6 embryo 18-20hr    6 embryo 20-22hr    5 embryo 22-24hr    7 larva L1    8 larva L2    8 larva L3 12hr old    6 larva L3 puffstage 1-2    7 larva L3 puffstage 3-6    12 larva L3 puffstage 7-9    14 white prepupae new    14 white prepupae 12hr    18 white prepupae 24hr    25 pupae 2d postWPP    27 pupae 3d postWPP    28 pupae 4d postWPP    22 adult male 01day    42 adult male 05day    50 adult male 30day    49 adult female 01day    26 adult female 05day    44 adult female 30day    44 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (38) embryo 02-04hr    5 embryo 04-06hr    5 embryo 06-08hr    4 embryo 08-10hr    4 embryo 10-12hr    3 embryo 12-14hr    5 embryo 14-16hr    5 embryo 16-18hr    6 embryo 18-20hr    6 embryo 20-22hr    5 embryo 22-24hr    7 larva L1    8 larva L2    8 larva L3 12hr old    6 larva L3 puffstage 1-2    7 larva L3 puffstage 3-6    12 larva L3 puffstage 7-9    14 white prepupae new    14 white prepupae 12hr    18 white prepupae 24hr    25 pupae 2d postWPP  (27) pupae 3d postWPP  (28) pupae 4d postWPP    22 adult male 01day  (42) adult male 05day  (50) adult male 30day  (49) adult female 01day  26 adult female 05day  (44) adult female 30day  (44) Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    38 embryo 02-04hr    5 embryo 04-06hr    5 embryo 06-08hr    4 embryo 08-10hr    4 embryo 10-12hr    3 embryo 12-14hr    5 embryo 14-16hr    5 embryo 16-18hr    6 embryo 18-20hr    6 embryo 20-22hr    5 embryo 22-24hr    7 larva L1    8 larva L2    8 larva L3 12hr old    6 larva L3 puffstage 1-2    7 larva L3 puffstage 3-6    12 larva L3 puffstage 7-9    14 white prepupae new    14 white prepupae 12hr    18 white prepupae 24hr    25 pupae 2d postWPP    27 pupae 3d postWPP    28 pupae 4d postWPP    22 adult male 01day    42 adult male 05day    50 adult male 30day    49 adult female 01day    26 adult female 05day    44 adult female 30day    44 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    38 embryo 02-04hr    5 embryo 04-06hr    5 embryo 06-08hr    4 embryo 08-10hr    4 embryo 10-12hr    3 embryo 12-14hr    5 embryo 14-16hr    5 embryo 16-18hr    6 embryo 18-20hr    6 embryo 20-22hr    5 embryo 22-24hr    7 larva L1    8 larva L2    8 larva L3 12hr old    6 larva L3 puffstage 1-2    7 larva L3 puffstage 3-6    12 larva L3 puffstage 7-9    14 white prepupae new    14 white prepupae 12hr    18 white prepupae 24hr    25 pupae 2d postWPP    27 pupae 3d postWPP    28 pupae 4d postWPP    22 adult male 01day    42 adult male 05day    50 adult male 30day    49 adult female 01day    26 adult female 05day    44 adult female 30day    44 Expression Level Scale  Extremely high  log, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    38 embryo 02-04hr    5 embryo 04-06hr    5 embryo 06-08hr    4 embryo 08-10hr    4 embryo 10-12hr    3 embryo 12-14hr    5 embryo 14-16hr    5 embryo 16-18hr    6 embryo 18-20hr    6 embryo 20-22hr    5 embryo 22-24hr    7 larva L1    8 larva L2    8 larva L3 12hr old    6 larva L3 puffstage 1-2    7 larva L3 puffstage 3-6    12 larva L3 puffstage 7-9    14 white prepupae new    14 white prepupae 12hr    18 white prepupae 24hr    25 pupae 2d postWPP    27 pupae 3d postWPP    28 pupae 4d postWPP    22 adult male 01day    42 adult male 05day    50 adult male 30day    49 adult female 01day    26 adult female 05day    44 adult female 30day    44 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (38) embryo 02-04hr    5 embryo 04-06hr    5 embryo 06-08hr    4 embryo 08-10hr    4 embryo 10-12hr    3 embryo 12-14hr    5 embryo 14-16hr    5 embryo 16-18hr    6 embryo 18-20hr    6 embryo 20-22hr    5 embryo 22-24hr    7 larva L1    8 larva L2    8 larva L3 12hr old    6 larva L3 puffstage 1-2    7 larva L3 puffstage 3-6    12 larva L3 puffstage 7-9    14 white prepupae new    14 white prepupae 12hr    18 white prepupae 24hr    25 pupae 2d postWPP  27 pupae 3d postWPP  28 pupae 4d postWPP    22 adult male 01day  (42) adult male 05day  (50) adult male 30day  (49) adult female 01day  26 adult female 05day  (44) adult female 30day  (44) Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    38 embryo 02-04hr    5 embryo 04-06hr    5 embryo 06-08hr    4 embryo 08-10hr    4 embryo 10-12hr    3 embryo 12-14hr    5 embryo 14-16hr    5 embryo 16-18hr    6 embryo 18-20hr    6 embryo 20-22hr    5 embryo 22-24hr    7 larva L1    8 larva L2    8 larva L3 12hr old    6 larva L3 puffstage 1-2    7 larva L3 puffstage 3-6    12 larva L3 puffstage 7-9    14 white prepupae new    14 white prepupae 12hr    18 white prepupae 24hr    25 pupae 2d postWPP    27 pupae 3d postWPP    28 pupae 4d postWPP    22 adult male 01day    42 adult male 05day    50 adult male 30day    49 adult female 01day    26 adult female 05day    44 adult female 30day    44 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    38 embryo 02-04hr    5 embryo 04-06hr    5 embryo 06-08hr    4 embryo 08-10hr    4 embryo 10-12hr    3 embryo 12-14hr    5 embryo 14-16hr    5 embryo 16-18hr    6 embryo 18-20hr    6 embryo 20-22hr    5 embryo 22-24hr    7 larva L1    8 larva L2    8 larva L3 12hr old    6 larva L3 puffstage 1-2    7 larva L3 puffstage 3-6    12 larva L3 puffstage 7-9    14 white prepupae new    14 white prepupae 12hr    18 white prepupae 24hr    25 pupae 2d postWPP    27 pupae 3d postWPP    28 pupae 4d postWPP    22 adult male 01day    42 adult male 05day    50 adult male 30day    49 adult female 01day    26 adult female 05day    44 adult female 30day    44 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     modENCODE Temporal Expression Data (Graveley et al., 2011)
modENCODE Cell Lines RNA-Seq
modENCODE Cell Line Expression Data (modENCODE_mRNA-Seq_cell.A) (modENCODE_mRNA-Seq_cell.B)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    40 Schneider line 2 Sg4    9 embryonic 1182-4H    12 embryonic GM2    24 embryonic Kc167    23 embryonic S1    15 embryonic S3    23 leg disc CME L1    11 wing disc CME-W2    17 wing disc ML-DmD8    11 wing disc ML-DmD9    13 wing disc ML-DmD16-c3    18 wing disc ML-DmD21    4 wing disc ML-DmD32    10 haltere disc ML-DmD17-c3    17 eye-antennal disc ML-DmD11    14 antennal disc ML-DmD20-c5    11 mixed discs ML-DmD4-c1    8 CNS ML-DmBG1-c1    19 CNS ML-DmBG2-c2    27 tumorous blood cells mbn2    33 ovary fGS/OSS    34 ovary OSC    15 ovary OSS    12 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+  (40) Schneider line 2 Sg4    9 embryonic 1182-4H    12 embryonic GM2    24 embryonic Kc167    23 embryonic S1    15 embryonic S3    23 leg disc CME L1    11 wing disc CME-W2    17 wing disc ML-DmD8    11 wing disc ML-DmD9    13 wing disc ML-DmD16-c3    18 wing disc ML-DmD21    4 wing disc ML-DmD32    10 haltere disc ML-DmD17-c3    17 eye-antennal disc ML-DmD11    14 antennal disc ML-DmD20-c5    11 mixed discs ML-DmD4-c1    8 CNS ML-DmBG1-c1    19 CNS ML-DmBG2-c2  (27) tumorous blood cells mbn2  (33) ovary fGS/OSS  (34) ovary OSC    15 ovary OSS    12 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    40 Schneider line 2 Sg4    9 embryonic 1182-4H    12 embryonic GM2    24 embryonic Kc167    23 embryonic S1    15 embryonic S3    23 leg disc CME L1    11 wing disc CME-W2    17 wing disc ML-DmD8    11 wing disc ML-DmD9    13 wing disc ML-DmD16-c3    18 wing disc ML-DmD21    4 wing disc ML-DmD32    10 haltere disc ML-DmD17-c3    17 eye-antennal disc ML-DmD11    14 antennal disc ML-DmD20-c5    11 mixed discs ML-DmD4-c1    8 CNS ML-DmBG1-c1    19 CNS ML-DmBG2-c2    27 tumorous blood cells mbn2    33 ovary fGS/OSS    34 ovary OSC    15 ovary OSS    12 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    40 Schneider line 2 Sg4    9 embryonic 1182-4H    12 embryonic GM2    24 embryonic Kc167    23 embryonic S1    15 embryonic S3    23 leg disc CME L1    11 wing disc CME-W2    17 wing disc ML-DmD8    11 wing disc ML-DmD9    13 wing disc ML-DmD16-c3    18 wing disc ML-DmD21    4 wing disc ML-DmD32    10 haltere disc ML-DmD17-c3    17 eye-antennal disc ML-DmD11    14 antennal disc ML-DmD20-c5    11 mixed discs ML-DmD4-c1    8 CNS ML-DmBG1-c1    19 CNS ML-DmBG2-c2    27 tumorous blood cells mbn2    33 ovary fGS/OSS    34 ovary OSC    15 ovary OSS    12 Expression Level Scale  Extremely high  log, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    40 Schneider line 2 Sg4    9 embryonic 1182-4H    12 embryonic GM2    24 embryonic Kc167    23 embryonic S1    15 embryonic S3    23 leg disc CME L1    11 wing disc CME-W2    17 wing disc ML-DmD8    11 wing disc ML-DmD9    13 wing disc ML-DmD16-c3    18 wing disc ML-DmD21    4 wing disc ML-DmD32    10 haltere disc ML-DmD17-c3    17 eye-antennal disc ML-DmD11    14 antennal disc ML-DmD20-c5    11 mixed discs ML-DmD4-c1    8 CNS ML-DmBG1-c1    19 CNS ML-DmBG2-c2    27 tumorous blood cells mbn2    33 ovary fGS/OSS    34 ovary OSC    15 ovary OSS    12 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  log, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+  (40) Schneider line 2 Sg4    9 embryonic 1182-4H    12 embryonic GM2    24 embryonic Kc167    23 embryonic S1    15 embryonic S3    23 leg disc CME L1    11 wing disc CME-W2    17 wing disc ML-DmD8    11 wing disc ML-DmD9    13 wing disc ML-DmD16-c3    18 wing disc ML-DmD21    4 wing disc ML-DmD32    10 haltere disc ML-DmD17-c3    17 eye-antennal disc ML-DmD11    14 antennal disc ML-DmD20-c5    11 mixed discs ML-DmD4-c1    8 CNS ML-DmBG1-c1    19 CNS ML-DmBG2-c2  27 tumorous blood cells mbn2  (33) ovary fGS/OSS  (34) ovary OSC    15 ovary OSS    12 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    40 Schneider line 2 Sg4    9 embryonic 1182-4H    12 embryonic GM2    24 embryonic Kc167    23 embryonic S1    15 embryonic S3    23 leg disc CME L1    11 wing disc CME-W2    17 wing disc ML-DmD8    11 wing disc ML-DmD9    13 wing disc ML-DmD16-c3    18 wing disc ML-DmD21    4 wing disc ML-DmD32    10 haltere disc ML-DmD17-c3    17 eye-antennal disc ML-DmD11    14 antennal disc ML-DmD20-c5    11 mixed discs ML-DmD4-c1    8 CNS ML-DmBG1-c1    19 CNS ML-DmBG2-c2    27 tumorous blood cells mbn2    33 ovary fGS/OSS    34 ovary OSC    15 ovary OSS    12 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    40 Schneider line 2 Sg4    9 embryonic 1182-4H    12 embryonic GM2    24 embryonic Kc167    23 embryonic S1    15 embryonic S3    23 leg disc CME L1    11 wing disc CME-W2    17 wing disc ML-DmD8    11 wing disc ML-DmD9    13 wing disc ML-DmD16-c3    18 wing disc ML-DmD21    4 wing disc ML-DmD32    10 haltere disc ML-DmD17-c3    17 eye-antennal disc ML-DmD11    14 antennal disc ML-DmD20-c5    11 mixed discs ML-DmD4-c1    8 CNS ML-DmBG1-c1    19 CNS ML-DmBG2-c2    27 tumorous blood cells mbn2    33 ovary fGS/OSS    34 ovary OSC    15 ovary OSS    12 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Cell Line   Expression Level Schneider line 2 S2R+     Schneider line 2 Sg4     embryonic 1182-4H     embryonic GM2     embryonic Kc167     embryonic S1     embryonic S3     leg disc CME L1     wing disc CME-W2     wing disc ML-DmD8     wing disc ML-DmD9     wing disc ML-DmD16-c3     wing disc ML-DmD21     wing disc ML-DmD32     haltere disc ML-DmD17-c3     eye-antennal disc ML-DmD11     antennal disc ML-DmD20-c5     mixed discs ML-DmD4-c1     CNS ML-DmBG1-c1     CNS ML-DmBG2-c2     tumorous blood cells mbn2     ovary fGS/OSS     ovary OSC     ovary OSS
modENCODE Treatments RNA-Seq
modENCODE Treatment Expression Data (modENCODE_mRNA-Seq_treatments)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    20 cold shock, 4-day adult    17 heat shock, 4-day adult    23 Cadmium 50 mM 6 hrs, larvae L3    5 Cadmium 50 mM 12 hrs, larvae L3    8 Cadmium 50 mM 48 hrs, 4-day adult    23 Cadmium 100 mM 48 hrs, 4-day adult    50 Copper 0.5 mM 12 hrs, larvae L3    9 Copper 15 mM 48 hrs, 4-day adult    42 Zinc 5 mM 12 hrs, larvae L3    10 Zinc 4.5 mM 48 hrs, 4-day adult    33 Ethanol 2.5% 3 hrs, larvae L3    44 Ethanol 5% 3 hrs, larvae L3    8 Ethanol 10% 3 hrs, larvae L3    6 Caffeine 1.5 mg/ml 4 hrs, larvae L3    6 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    38 Caffeine 25 mg/ml 48 hrs, 4-day adult    20 Paraquat 5 mM 48 hrs, 4-day adult    40 Paraquat 10 mM 48 hrs, 4-day adult    44 Rotenone 2 μg 12 hrs, larvae L3    8 Rotenone 8 μg 12 hrs, larvae L3    5 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  Linear, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult    20 cold shock, 4-day adult    17 heat shock, 4-day adult    23 Cadmium 50 mM 6 hrs, larvae L3    5 Cadmium 50 mM 12 hrs, larvae L3    8 Cadmium 50 mM 48 hrs, 4-day adult    23 Cadmium 100 mM 48 hrs, 4-day adult  (50) Copper 0.5 mM 12 hrs, larvae L3    9 Copper 15 mM 48 hrs, 4-day adult  (42) Zinc 5 mM 12 hrs, larvae L3    10 Zinc 4.5 mM 48 hrs, 4-day adult  (33) Ethanol 2.5% 3 hrs, larvae L3  (44) Ethanol 5% 3 hrs, larvae L3    8 Ethanol 10% 3 hrs, larvae L3    6 Caffeine 1.5 mg/ml 4 hrs, larvae L3    6 Caffeine 2.5 mg/ml 48 hrs, 4-day adult  (38) Caffeine 25 mg/ml 48 hrs, 4-day adult    20 Paraquat 5 mM 48 hrs, 4-day adult  (40) Paraquat 10 mM 48 hrs, 4-day adult  (44) Rotenone 2 μg 12 hrs, larvae L3    8 Rotenone 8 μg 12 hrs, larvae L3    5 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    20 cold shock, 4-day adult    17 heat shock, 4-day adult    23 Cadmium 50 mM 6 hrs, larvae L3    5 Cadmium 50 mM 12 hrs, larvae L3    8 Cadmium 50 mM 48 hrs, 4-day adult    23 Cadmium 100 mM 48 hrs, 4-day adult    50 Copper 0.5 mM 12 hrs, larvae L3    9 Copper 15 mM 48 hrs, 4-day adult    42 Zinc 5 mM 12 hrs, larvae L3    10 Zinc 4.5 mM 48 hrs, 4-day adult    33 Ethanol 2.5% 3 hrs, larvae L3    44 Ethanol 5% 3 hrs, larvae L3    8 Ethanol 10% 3 hrs, larvae L3    6 Caffeine 1.5 mg/ml 4 hrs, larvae L3    6 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    38 Caffeine 25 mg/ml 48 hrs, 4-day adult    20 Paraquat 5 mM 48 hrs, 4-day adult    40 Paraquat 10 mM 48 hrs, 4-day adult    44 Rotenone 2 μg 12 hrs, larvae L3    8 Rotenone 8 μg 12 hrs, larvae L3    5 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    20 cold shock, 4-day adult    17 heat shock, 4-day adult    23 Cadmium 50 mM 6 hrs, larvae L3    5 Cadmium 50 mM 12 hrs, larvae L3    8 Cadmium 50 mM 48 hrs, 4-day adult    23 Cadmium 100 mM 48 hrs, 4-day adult    50 Copper 0.5 mM 12 hrs, larvae L3    9 Copper 15 mM 48 hrs, 4-day adult    42 Zinc 5 mM 12 hrs, larvae L3    10 Zinc 4.5 mM 48 hrs, 4-day adult    33 Ethanol 2.5% 3 hrs, larvae L3    44 Ethanol 5% 3 hrs, larvae L3    8 Ethanol 10% 3 hrs, larvae L3    6 Caffeine 1.5 mg/ml 4 hrs, larvae L3    6 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    38 Caffeine 25 mg/ml 48 hrs, 4-day adult    20 Paraquat 5 mM 48 hrs, 4-day adult    40 Paraquat 10 mM 48 hrs, 4-day adult    44 Rotenone 2 μg 12 hrs, larvae L3    8 Rotenone 8 μg 12 hrs, larvae L3    5 Expression Level Scale  Extremely high  log, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    20 cold shock, 4-day adult    17 heat shock, 4-day adult    23 Cadmium 50 mM 6 hrs, larvae L3    5 Cadmium 50 mM 12 hrs, larvae L3    8 Cadmium 50 mM 48 hrs, 4-day adult    23 Cadmium 100 mM 48 hrs, 4-day adult    50 Copper 0.5 mM 12 hrs, larvae L3    9 Copper 15 mM 48 hrs, 4-day adult    42 Zinc 5 mM 12 hrs, larvae L3    10 Zinc 4.5 mM 48 hrs, 4-day adult    33 Ethanol 2.5% 3 hrs, larvae L3    44 Ethanol 5% 3 hrs, larvae L3    8 Ethanol 10% 3 hrs, larvae L3    6 Caffeine 1.5 mg/ml 4 hrs, larvae L3    6 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    38 Caffeine 25 mg/ml 48 hrs, 4-day adult    20 Paraquat 5 mM 48 hrs, 4-day adult    40 Paraquat 10 mM 48 hrs, 4-day adult    44 Rotenone 2 μg 12 hrs, larvae L3    8 Rotenone 8 μg 12 hrs, larvae L3    5 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  log, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult    20 cold shock, 4-day adult    17 heat shock, 4-day adult    23 Cadmium 50 mM 6 hrs, larvae L3    5 Cadmium 50 mM 12 hrs, larvae L3    8 Cadmium 50 mM 48 hrs, 4-day adult    23 Cadmium 100 mM 48 hrs, 4-day adult  (50) Copper 0.5 mM 12 hrs, larvae L3    9 Copper 15 mM 48 hrs, 4-day adult  (42) Zinc 5 mM 12 hrs, larvae L3    10 Zinc 4.5 mM 48 hrs, 4-day adult  (33) Ethanol 2.5% 3 hrs, larvae L3  (44) Ethanol 5% 3 hrs, larvae L3    8 Ethanol 10% 3 hrs, larvae L3    6 Caffeine 1.5 mg/ml 4 hrs, larvae L3    6 Caffeine 2.5 mg/ml 48 hrs, 4-day adult  (38) Caffeine 25 mg/ml 48 hrs, 4-day adult    20 Paraquat 5 mM 48 hrs, 4-day adult  (40) Paraquat 10 mM 48 hrs, 4-day adult  (44) Rotenone 2 μg 12 hrs, larvae L3    8 Rotenone 8 μg 12 hrs, larvae L3    5 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    20 cold shock, 4-day adult    17 heat shock, 4-day adult    23 Cadmium 50 mM 6 hrs, larvae L3    5 Cadmium 50 mM 12 hrs, larvae L3    8 Cadmium 50 mM 48 hrs, 4-day adult    23 Cadmium 100 mM 48 hrs, 4-day adult    50 Copper 0.5 mM 12 hrs, larvae L3    9 Copper 15 mM 48 hrs, 4-day adult    42 Zinc 5 mM 12 hrs, larvae L3    10 Zinc 4.5 mM 48 hrs, 4-day adult    33 Ethanol 2.5% 3 hrs, larvae L3    44 Ethanol 5% 3 hrs, larvae L3    8 Ethanol 10% 3 hrs, larvae L3    6 Caffeine 1.5 mg/ml 4 hrs, larvae L3    6 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    38 Caffeine 25 mg/ml 48 hrs, 4-day adult    20 Paraquat 5 mM 48 hrs, 4-day adult    40 Paraquat 10 mM 48 hrs, 4-day adult    44 Rotenone 2 μg 12 hrs, larvae L3    8 Rotenone 8 μg 12 hrs, larvae L3    5 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    20 cold shock, 4-day adult    17 heat shock, 4-day adult    23 Cadmium 50 mM 6 hrs, larvae L3    5 Cadmium 50 mM 12 hrs, larvae L3    8 Cadmium 50 mM 48 hrs, 4-day adult    23 Cadmium 100 mM 48 hrs, 4-day adult    50 Copper 0.5 mM 12 hrs, larvae L3    9 Copper 15 mM 48 hrs, 4-day adult    42 Zinc 5 mM 12 hrs, larvae L3    10 Zinc 4.5 mM 48 hrs, 4-day adult    33 Ethanol 2.5% 3 hrs, larvae L3    44 Ethanol 5% 3 hrs, larvae L3    8 Ethanol 10% 3 hrs, larvae L3    6 Caffeine 1.5 mg/ml 4 hrs, larvae L3    6 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    38 Caffeine 25 mg/ml 48 hrs, 4-day adult    20 Paraquat 5 mM 48 hrs, 4-day adult    40 Paraquat 10 mM 48 hrs, 4-day adult    44 Rotenone 2 μg 12 hrs, larvae L3    8 Rotenone 8 μg 12 hrs, larvae L3    5 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Treatment   Expression Level extended cold, 4-day adult     cold shock, 4-day adult     heat shock, 4-day adult     Cadmium 50 mM 6 hrs, larvae L3     Cadmium 50 mM 12 hrs, larvae L3     Cadmium 50 mM 48 hrs, 4-day adult     Cadmium 100 mM 48 hrs, 4-day adult     Copper 0.5 mM 12 hrs, larvae L3     Copper 15 mM 48 hrs, 4-day adult     Zinc 5 mM 12 hrs, larvae L3     Zinc 4.5 mM 48 hrs, 4-day adult     Ethanol 2.5% 3 hrs, larvae L3     Ethanol 5% 3 hrs, larvae L3     Ethanol 10% 3 hrs, larvae L3     Caffeine 1.5 mg/ml 4 hrs, larvae L3     Caffeine 2.5 mg/ml 48 hrs, 4-day adult     Caffeine 25 mg/ml 48 hrs, 4-day adult     Paraquat 5 mM 48 hrs, 4-day adult     Paraquat 10 mM 48 hrs, 4-day adult     Rotenone 2 μg 12 hrs, larvae L3     Rotenone 8 μg 12 hrs, larvae L3
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (Graveley et al., 2011) mE1_20_mRNA_expression_cluster_09
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0261397
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele lethal | embryonic stage | germline clone | maternal effect | recessive didum154 lethal | embryonic stage | germline clone | non-rescuable maternal effect | recessive didum88 didum89 didum154 didum219 didum234 lethal | larval stage | recessive didumunspecified lethal | recessive | third instar larval stage didumQ1052st viable, with Scer\GAL4pnr-MD237 didumGD1848 Sterility Allele female fertile didumQ1052st female fertile | germline clone didumQ1052st male sterile | recessive didumQ1052st Other Phenotypes Allele developmental rate defective didumunspecified developmental rate defective | recessive didumQ1052st Phenotype manifest in Allele embryo | germline clone | maternal effect | posterior didum154 didum89 didum219 didum234 didum88 embryonic abdomen | germline clone | maternal effect didum154 embryonic head | germline clone | maternal effect didum154 didum89 didum219 didum234 didum88 eye photoreceptor cell | somatic clone didumQ1052st filzkorper | germline clone | maternal effect didum154 didum89 didum219 didum234 didum88 male genitalia, with Scer\GAL4Abd-B-LDN didumGD1848 male genitalia, with Scer\GAL4tsh-md621 didumGD1848 ovary | germline clone | maternal effect didum154 didumKG04384 pole cell | germline clone | maternal effect didum154 didum89 didum219 didum234 didum88 rhabdomere | ectopic didumKG04384 rhabdomere | ectopic | somatic clone didumQ1052st rhabdomere | somatic clone didumQ1052st spermatid cyst didumQ1052st spermatozoon didumQ1052st
Classical Alleles ( 10 )
For All Classical Alleles Show
Allele of didum Class Mutagen Stocks Known lesion didumKG04384 P-element activity 1 Yes didum154 ethyl methanesulfonate 0 Yes didum219 ethyl methanesulfonate 0 Yes didum234 ethyl methanesulfonate 0 Yes didum88 ethyl methanesulfonate 0 Yes didum89 ethyl methanesulfonate 0 Yes didumd28 P-element activity 0 Yes didumQ1024st 0 -- didumQ1052st loss of function allele ethyl methanesulfonate 0 Yes didumunspecified 0 --
Alleles Carried on Transgenic Constructs ( 8 )
For All Alleles Carried on Transgenic Constructs Show
Allele of didum Class Mutagen Stocks Known lesion didumGD1848 in vitro construct - RNAi in vitro construct - regulatory fusion 3 Yes didum+t7.52 in vitro construct - genomic fragment 0 Yes didumCT.Scer\UAS.T:Avic\GFP in vitro construct - regulatory fusion 0 Yes didumdsRNA.1501-1860.Scer\UAS in vitro construct - regulatory fusion in vitro construct - RNAi 0 Yes didumdsRNA.4801-5160.Scer\UAS in vitro construct - regulatory fusion in vitro construct - RNAi 0 Yes didumGT.Scer\UAS.P\T in vitro construct - regulatory fusion 0 Yes didumMotor.Scer\UAS.P\T in vitro construct - regulatory fusion 0 Yes didumScer\UAS.P\T.T:Avic\GFP-EGFP in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes
Aneuploid Aberrations
Disrupted in	Df(2R)del28 (Mermall et al., 2005) Df(2R)Drlrv21 (Mermall et al., 2005) Df(2R)Drlrv22 (Mermall et al., 2005) Df(2R)Exel6052 (Ryder, 2004.4.26)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD1848} NA P{UAS-didum.CT-GFP} NA P{UAS-didum.RNAi.1501-1860} NA P{UAS-didum.RNAi.4801-5160} NA P{UASp-didum.FL.EGFP} NA P{UASp-didum.GT} NA P{UASp-didum.Motor} NA characterization construct P{didum+t7.52} NA
Insertions
	Type of insertions Name Expression data miscellaneous insertions P{SUPor-P}didumKG04384 NA
Gene Ontology: Function, Process & Cellular Component ( 16 unique terms )
Terms Based on Experimental Evidence ( 13 terms )
Molecular Function
CV term Evidence References
actin binding inferred from direct assay (Toth et al., 2005) actin-dependent ATPase activity inferred from direct assay (Toth et al., 2005) ATP binding inferred from direct assay (Toth et al., 2005) calmodulin binding inferred from physical interaction with Cam (Martin and Bayley, 2004) myosin light chain binding inferred from physical interaction with Cam (Toth et al., 2005) inferred from physical interaction with Mlc-c (Franke et al., 2006, Toth et al., 2005)
Biological Process
CV term Evidence References
actin filament-based movement inferred from direct assay (Toth et al., 2005) anterior/posterior axis specification, embryo inferred from mutant phenotype (Luschnig et al., 2004) mitochondrion transport along microtubule inferred from direct assay (Pathak et al., 2010) NOT oogenesis inferred from mutant phenotype (Mermall et al., 2005) positive regulation of pole plasm oskar mRNA localization inferred from mutant phenotype (Krauss et al., 2009, Krauss et al., 2009) rhabdomere development inferred from mutant phenotype (Li et al., 2007) sperm individualization inferred from mutant phenotype (Mermall et al., 2005)
Cellular Component
CV term Evidence References
myosin V complex inferred from physical interaction with Cam (Martin and Bayley, 2004) inferred from physical interaction with Mlc-c (Franke et al., 2006)
Terms Based on Predictions or Assertions ( 6 terms )
Molecular Function
CV term Evidence References
actin binding inferred from sequence or structural similarity with mouse Myo5a (FlyBase, 1992-, MacIver et al., 1998, Bonafe and Sellers, 1998) ATPase activity, coupled inferred from sequence or structural similarity (Goldstein and Gunawardena, 2000) ATP binding inferred from sequence or structural similarity with mouse Myo5a (MacIver et al., 1998, Bonafe and Sellers, 1998) calmodulin binding inferred from sequence or structural similarity with mouse Myo5a (FlyBase, 1992-) motor activity inferred from sequence or structural similarity with mouse Myo5a (FlyBase, 1992-)
Biological Process ( 0 terms)
Cellular Component
CV term Evidence References
myosin complex inferred from sequence or structural similarity (Goldstein and Gunawardena, 2000) inferred from sequence or structural similarity with mouse Myo5a (FlyBase, 1992-, MacIver et al., 1998, Bonafe and Sellers, 1998)
Sequence Ontology: Class of Gene
	gene   gene_with_edited_transcript (Graveley et al., 2011) nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
protein-protein
Interacting group Assay References
didum - Act57B experimental knowledge based (Guruharsha et al., 2011) didum - Arp2 experimental knowledge based (Guruharsha et al., 2011) didum - Arpc2 experimental knowledge based (Guruharsha et al., 2011) didum - CG1041 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) didum - CG10641 experimental knowledge based (Guruharsha et al., 2011) didum - CG13900 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) didum - CG1971 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) didum - CG31633 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) didum - CG33156 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) didum - CG6453 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) didum - CG9602 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) didum - Cbp20 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) didum - Cks85A anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) didum - Cpr100A anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) didum - Patj anti bait coimmunoprecipitation, peptide massfingerprinting, western blot (Pocha et al., 2011) didum - SP2637 anti tag coimmunoprecipitation, peptide massfingerprinting, experimental knowledge based (Mintseris et al., 2009.11.23, Guruharsha et al., 2011) didum - Tsp42Ed anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) didum - Tudor-SN anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) didum - blp anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) didum - cpa experimental knowledge based (Guruharsha et al., 2011) didum - cpb experimental knowledge based (Guruharsha et al., 2011) didum - sdt anti bait coimmunoprecipitation, western blot, peptide massfingerprinting (Pocha et al., 2011) didum - ste14 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) didum - twin anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) didum - wda anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23)
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions didum allele Gene References
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 61556 DroID - A comprehensive database of gene and protein interactions. • FBgn0261397 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 35680
Orthologs
OrthoDB Orthologs (55) - based on analysis using Dmel annotation version 5.41
OrthoDB Ortholog Groups
	OrthoDB orthology group searches (Waterhouse et al., 2011, Nucleic Acids Res. 39(Database issue): D283--D288) Drosophila inclusive ortholog search EOG6NCMZ1 Dipteran inclusive ortholog search EOG69GKQH Insect inclusive ortholog search EOG6H44ZM Arthropod inclusive ortholog search EOG6PRR5P Metazoa inclusive ortholog search EOG68DCN4
Orthologs in Drosophila Species (EOG6NCMZ1)
Organism Common Name Gene AAA Syntenic Ortholog Multiple Dmel Genes in this Orthologous Group Drosophila melanogaster fruit fly  Dmel\didum     Drosophila simulans   Dsim\GD10485 Y   Drosophila sechellia   Dsec\GM20959 Y   Drosophila erecta   Dere\GG23282 Y   Drosophila yakuba   Dyak\GE19129 Y   Drosophila ananassae   Dana\GF11201 Y   Drosophila pseudoobscura pseudoobscura   Dpse\GA15267 Y   Drosophila persimilis   Dper\GL20011 Y   Drosophila willistoni   Dwil\GK10684 Y   Drosophila virilis   Dvir\GJ22297 Y   Drosophila mojavensis   Dmoj\GI19162 Y   Drosophila grimshawi   Dgri\GH22080 Y
Orthologs in non-Drosophila Dipterans (EOG69GKQH)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Aedes aegypti Yellow fever mosquito  Aaeg\AAEL009357   Anopheles gambiae Malaria mosquito  Agam\AGAP006479   Culex quinquefasciatus Southern house mosquito  Cqui\CPIJ009300
Orthologs in non-Dipteran Insects (EOG6H44ZM)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Apis mellifera Western honey bee  Amel\GB50690   Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG006416   Acromyrmex echinatior Panamanian leafcutter ant  Aech\AECH21565   Atta cephalotes Leafcutter ant  Acep\ACEP15333   Camponotus floridanus Florida carpenter ant  Cflo\CFLO17016   Camponotus floridanus Florida carpenter ant  Cflo\CFLO14594   Harpegnathos saltator Jerdons jumping ant  Hsal\HSAL18691   Linepithema humile Argentine ant  Lhum\LH11771   Pogonomyrmex barbatus Red harvester ant  Pbar\PB12769   Solenopsis invicta Red fire ant  Sinv\SINV15890   Acyrthosiphon pisum Pea aphid  Apim\ACYPI005774   Acyrthosiphon pisum Pea aphid  Apim\ACYPI26900   Bombyx mori Silkmoth  Bmor\BGIBMGA009779   Pediculus humanus Human body louse  Phum\PHUM047290   Tribolium castaneum Red flour beetle  Tcas\TC009935
Orthologs in non-Insect Arthropods (EOG6PRR5P)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Daphnia pulex Water flea  Dpux\JGI_V11_308269   Ixodes scapularis Deer tick  Isca\ISCW021017
Orthologs in non-Arthropod Metazoa (EOG68DCN4)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Caenorhabditis elegans Nematode  Cele\hum-2   Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_001160gn   Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_000832gn   Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_003901gn   Danio rerio Zebrafish  Drer\ENSDARG00000013782   Danio rerio Zebrafish  Drer\myo5ab   Danio rerio Zebrafish  Drer\myo5b   Danio rerio Zebrafish  Drer\myo5aa   Danio rerio Zebrafish  Drer\ENSDARG00000062003   Danio rerio Zebrafish  Drer\si:dkey-110c1.10   Xenopus tropicalis Western clawed frog  Xtro\myo5b   Xenopus tropicalis Western clawed frog  Xtro\ENSXETG00000020739   Xenopus tropicalis Western clawed frog  Xtro\myo5a   Gallus gallus Domestic chicken  Ggal\MYO5C   Gallus gallus Domestic chicken  Ggal\MYO5A   Mus musculus House mouse  Mmus\Myo5b   Mus musculus House mouse  Mmus\Myo5c   Rattus norvegicus Norway rat  Rnor\Myo5b   Rattus norvegicus Norway rat  Rnor\ENSRNOG00000022968   Rattus norvegicus Norway rat  Rnor\ENSRNOG00000008356   Homo sapiens Human  Hsap\MYO5B   Homo sapiens Human  Hsap\MYO5A   Homo sapiens Human  Hsap\MYO5C
Human Orthologs (3)
Gene OMIM HGNC Hsap\MYO5B     Hsap\MYO5A     Hsap\MYO5C
AAA Orthologs (11) based on analysis using Dmel annotation version 4.3
Organism Gene Drosophila simulans Dsim\GD10485 Drosophila sechellia Dsec\GM20959 Drosophila erecta Dere\GG23282 Drosophila yakuba Dyak\GE19129 Drosophila ananassae Dana\GF11201 Drosophila pseudoobscura pseudoobscura Dpse\GA15267 Drosophila persimilis Dper\GL20011 Drosophila willistoni Dwil\GK10684 Drosophila virilis Dvir\GJ22297 Drosophila mojavensis Dmoj\GI19162 Drosophila grimshawi Dgri\GH22080
Stocks & Reagents
Stocks Listed in FlyBase ( 4 )
Bloomington	14094 y1; P{SUPor-P}didumKG04384/CyO
VDRC	v16902 w1118; P{GD1848}v16902 v44291 w1118; P{GD1848}v44291 v44292 w1118; P{GD1848}v44292
Genomic Clones ( 2 )
	BACR04G20 BACR04H12 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 55 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	RE30195
Other clones
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	AT06823 AT12106 AT16787 AT18660 AT19809 AT20260 AT20454 AT20539 AT21566 AT22028 AT23192 AT26563 AT26945 AT27186 AT29169 AT29341 AT30089 AT30743 GH22522 LD25801
Other clones	823 17234 53083 61397 74184 214471.44 272964 AT01176 bs14c05 bs71c12 CK01.56B.B8 CK01.62D.F11 EC051268 EC052814 EC053294 EC055168 EK045540 EK050524 EK073203 EK116904 EK121717 EK129421 EK135502 EK170019 EK185125 EP10437 GH04445 RP004162553 RP004198062 RP004198303 RP004222604 RP004239531 RP004412683 RP004495064
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0261397 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 35680
Antibody Information
	polyclonal (Krauss et al., 2009, Finan et al., 2011)
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of	Source for identity of: didum CG2146 (Gabrielian, 1999.11)
Source for database merge of	Source for merge of: didum NEST:bs14c05 (FlyBase, 1996-) Source for merge of: soy didum (Krauss et al., 2009)
Additional comments	soy mutants complement tud and stau mutants. (Luschnig et al., 2004) "l(2)43Cc" may correspond to "didum"; there is a band shift in the didum genomic region associated with the "l(2)43Cc4" mutation which is not a polymorphism, although it maps several kilobases 5' of the cloned genomic didum sequence. (MacIver et al., 1998) Source for merge of didum NEST:bs14c05 was sequence comparison (date:031022). (FlyBase, 1996-)
Other Comments
	didum is required for wls protein-containing exosome release at synaptic boutons. (Koles et al., 2012) didum knockdown increases axonal mitochondrial length. didum acts to interrupt mitochondrial transport on microtubules to decrease the duty cycle and perhaps facilitate docking. (Pathak et al., 2010) didum protein associates with the osk mRNA transport complex preferentially at the oocyte cortex. (Krauss et al., 2009) One of 42 Drosophila genes identified as being most likely to reveal molecular and cellular mechanisms of nervous system development or plasticity relevant to human Mental Retardation disorders. (Inlow and Restifo, 2004) dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R+ cell morphology. (Kiger et al., 2003) dsRNA made from templates generated with primers directed against this gene is tested in an RNAi screen for effects on actin-based lamella formation. (Rogers et al., 2003) Area matching Drosophila myosin V gene (inverted), Acc. No. AF003826. (Davies, 2001.3.15)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_057838 NM_165535 NM_165536 RefSeq (Proteins) • NP_477186 NP_724569 NP_724570 DDBJ / EMBL / GenBank • AAC99496 AAF59241 AAM68902 AAM68903 AAQ22472 AC004280 AF003826 AI064168 AI945561 AX093905 BG632162 BH840533 BI234491 BT010003 CAA69352 Y08160 Entrez Gene - A searchable database of RefSeq genes. • 35680 UniProtKB/TrEMBL • A1Z6Z8 A1Z6Z9 A1Z700 O97417 Q7YU40 Q94882
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • P-loop containing nucleoside triphosphate hydrolase (IPR027417) IQ motif, EF-hand binding site (IPR000048) Myosin head, motor domain (IPR001609) Dilute (IPR002710) Dil domain (IPR018444)
Linkouts
	BioGRID - A database of protein and genetic interactions • 61556 DroID - A comprehensive database of gene and protein interactions. • FBgn0261397 DRSC - Results from RNAi screens. • FBgn0261397 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0261397 FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0261397 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 35680 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 35680 modMine - Data generated by the modENCODE project. • FBgn0261397
Synonyms & Secondary IDs ( 21 )
Reported As
Symbol Synonym	43CD (Oliver et al., 1999) CG2146 (Goldstein and Gunawardena, 2000, Rogers et al., 2003, Perkins et al., 2009, Petzoldt et al., 2012) didum (Finan et al., 2011, Krauss et al., 2009, Mermall et al., 2005, Texada et al., 2007, Franke et al., 2006, Stuart et al., 2007, Liebl et al., 2006, Nelson et al., 2005, Wang and Lin, 2007, Haerty et al., 2007, Dworkin et al., 2009, Krauss et al., 2009, Liebl and Featherstone, 2005, Burgler and Macdonald, 2005, Petzoldt et al., 2012) Didum (Liebl and Featherstone, 2008, Bandyopadhyay et al., 2006) DmV (Yamashita et al., 2000, Toth et al., 2005) M5 (Finan et al., 2011) Myo5 (Koles et al., 2012) MyoV (Krauss et al., 2009, Mermall et al., 2005, Yamashita et al., 2000, Li et al., 2007, Satoh et al., 2008, Windler and Bilder, 2010, Gault et al., 2012) MYOV (Goldstein and Gunawardena, 2000) myoV (Massarwa et al., 2009) MyoV43CD (Bonafe and Sellers, 1998, ) NEST:bs14c05   NMC7 (MacIver et al., 1998) soy   unnamed (McCormack et al., 1996)
Name Synonym	dilute class unconventional myosin (Nelson et al., 2005, Wang and Lin, 2007) myosin V (Finan et al., 2011, Welte, 2004, Bonafe et al., 2002, Goldstein and Gunawardena, 2000, Bonafe et al., 1999, Bonafe and Sellers, 1997, Rogers et al., 2003, Bonafe, 1997.5.12, McCormack et al., 1998, Bonafe and Sellers, 1998, Toth et al., 2005, Pathak et al., 2010, Nagy et al., 2009) MyosinV (Shah et al., 2004) myosin-V (Bonafe et al., 1996) Myosin V (Rogers et al., 2003, Satoh et al., 2008, Serio et al., 2010) shorty (Luschnig et al., 2004, Luschnig et al., 2004, Krauss et al., 2009, Krauss et al., 2009)
Secondary FlyBase IDs
	FBgn0015933 FBgn0023490 FBgn0045305 FBgn0069080
References ( 78 )
Generate a list of	All references relating to this gene ( 78 )
List References by type	Research paper  ( 38 ) Supplementary material  ( 12 ) Review  ( 3 ) Personal communication to FlyBase  ( 8 ) Abstract  ( 8 ) FlyBase analysis  ( 2 ) DNA/RNA sequence record  ( 3 ) Curated genome annotation  ( 3 ) Patent  ( 1 )
Recent research papers ( 5 )
	Gault et al., 2012, J. Cell Biol. 196(5): 605--621 Drosophila CK1-γ, gilgamesh, controls PCP-mediated morphogenesis through regulation of vesicle trafficking. [FBrf0217630] Koles et al., 2012, J. Biol. Chem. 287(20): 16820--16834 Mechanism of evenness interrupted (evi)-exosome release at synaptic boutons. [FBrf0218323] Petzoldt et al., 2012, Development 139(10): 1874--1884 DE-Cadherin regulates unconventional Myosin ID and Myosin IC in Drosophila left-right asymmetry establishment. [FBrf0218056] Finan et al., 2011, Proc. Natl. Acad. Sci. U.S.A. 108(14): 5566--5571 From the Cover: Proteomics approach to study the functions of Drosophila myosin VI through identification of multiple cargo-binding proteins. [FBrf0213355] Pocha et al., 2011, J. Cell Biol. 195(5): 827--838 Crumbs regulates rhodopsin transport by interacting with and stabilizing myosin V. [FBrf0217316] Show all research papers ...
Recent reviews (0)
	All reviews listed in FlyBase were published before 2011 Show reviews ...