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FB2025_05
,
released December 11, 2025
Ogt, O-GlcNAc transferase, l(2)02637, l(2)NC130, sxc/Ogt
enzyme and polycomb factor - induces Hipk-mediated tumor-like growth proteasomal degradation - Hipk is O-GlcNAcylated by OGT - cooperates with N-glycanase to regulate proliferation in intestinal stem cells (ISCs) and apoptosis in differentiated enterocytes - controls of synaptic size and synaptic bouton number at the neuromuscular junction - part of a clock-regulated buffering mechanism that prevent excessive O-GlcNAcylation at non-optimal times of the day-night cycle - O-GlcNAcylation of TDP-43 suppresses ALS-associated proteinopathies and promotes TDP-43's splicing function - plays a role in habituation learning - O-GlcNAcylation is needed for Polyhomeotic to form functional, ordered assemblies
Please see the JBrowse view of Dmel\sxc for information on other features
To submit a correction to a gene model please use the Contact FlyBase form
AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.
Low-frequency RNA-Seq exon junction(s) not annotated.
Gene model reviewed during 5.47
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\sxc using the Feature Mapper tool.
The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).
Comment: maternally deposited
JBrowse - Visual display of RNA-Seq signals
View Dmel\sxc in JBrowsePlease Note FlyBase no longer curates genomic clone accessions so this list may not be complete
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
New stable cell line derived from S2-unspecified : S2 cell lines expressing circCG32369, circMCPH1, circeIF5B, circrl, circPde11, circCG17715, circzfh2, circTao, circcrol, circdrn, circMeltrin, circpxb, circfru, circdati, circstw, circSarm, circStim, circCG2991, circPvr, circHil, circmub, circsxc, circbnl, and circCG9743 were created. The author reports new stable cell lines S2-circMCPH1, S2-circCG32369, S2-Flag-Ddx56 , and S2-Flag-gw.
Identification: During an EMS mutagenesis for lethal mutations uncovered by Df(2R)M41A8.
In an effort to subdivide the Pc-group genes functionally, the phenotypes of adult flies heterozygous for every pairwise combination of Pc-group mutation were examined. Genetic interactions have been demonstrated between esc, Asx, E(Pc), Pcl, E(z) and sxc. Most duplications of Pc-group genes neither exhibit anterior transformations nor suppress the extra sex comb phenotype of Pc-group mutations, suggesting that not all Pc-group genes behave as predicted by the mass action model.
The Pc group genes are negative regulators of homeotic genes.
Source for merge of: sxc l(2)NC130
Source for merge of: Ogt BcDNA:GH04245
Source for merge of: sxc Ogt
FlyBase Curator comment: Added "l(2)02637" symbol synonym to sxc as FBrf0209489 states that the lethality associated with the "l(2)02637" line is caused by a second lesion, the Transpac{}sxc02637 insertion, in the sxc gene and not the P{PZ}L02637 insertion in the L gene.
