FB2022_02, released March 29, 2022

Gene: Dmel\sxc

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General Information
Symbol
Dmel\sxc
Species
D. melanogaster
Name
super sex combs
Annotation Symbol
CG10392
Feature Type
protein_coding_gene
FlyBase ID
FBgn0261403
Gene Model Status
Current
Stock Availability
17 publicly available
Enzyme Name (EC)
Protein O-GlcNAc transferase (2.4.1.255)
Protein N-acetylglucosaminyltransferase (2.4.1.94)
Gene Summary
super sex combs (sxc) is a polycomb group gene that encodes a O-GlcNAc transferase involved in epigenetic gene silencing. [Date last reviewed: 2019-09-12] (FlyBase Gene Snapshot)
All Summaries
Also Known As

Ogt, O-GlcNAc transferase, l(2)NC130, l(2)02637, O-glycosyltransferase

Key Links
Genomic Location
Cytogenetic map
41C1-41C2
Sequence location
Recombination map
2-55
RefSeq locus
NT_033778 REGION:5307288..5329555
Sequence
Get Decorated FASTA
Genomic Maps
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
NCBI
UCSC
Ensembl
PopFly
Function
GO Summary Ribbons
Gene Ontology (GO) Annotations (10 terms)
Molecular Function (3 terms)
Terms Based on Experimental Evidence (2 terms)
CV Term
Evidence
References
enables glycosyltransferase activity
inferred from mutant phenotype
(Gambetta and Müller, 2014)
enables protein O-GlcNAc transferase activity
inferred from mutant phenotype
(Gambetta and Müller, 2014, Sinclair et al., 2009)
inferred from mutant phenotype
(assigned by UniProt )
(Radermacher et al., 2014)
inferred from direct assay
(Mariappa et al., 2011)
Terms Based on Predictions or Assertions (1 term)
CV Term
Evidence
References
enables protein N-acetylglucosaminyltransferase activity
inferred from biological aspect of ancestor with PANTHER:PTN002892972
(assigned by GO_Central )
(Gaudet et al., 2011)
Biological Process (7 terms)
Terms Based on Experimental Evidence (7 terms)
CV Term
Evidence
References
involved_in glycoprotein metabolic process
inferred from mutant phenotype
(assigned by UniProt )
(Radermacher et al., 2014)
involved_in locomotor rhythm
inferred from mutant phenotype
(Kaasik et al., 2013)
involved_in positive regulation of fibroblast growth factor receptor signaling pathway
inferred from genetic interaction with FLYBASE:nst; FB:FBgn0036298
(Mariappa et al., 2011)
involved_in protein O-linked glycosylation
inferred from mutant phenotype
(Pravata et al., 2019, Mariappa et al., 2018, Gambetta and Müller, 2014, Gambetta et al., 2009)
inferred from direct assay
(Mariappa et al., 2011)
involved_in regulation of gene expression
inferred from mutant phenotype
(Akan et al., 2016)
involved_in response to temperature stimulus
inferred from mutant phenotype
(assigned by UniProt )
(Radermacher et al., 2014)
involved_in wing disc development
inferred from mutant phenotype
(Gambetta et al., 2009)
Terms Based on Predictions or Assertions (1 term)
CV Term
Evidence
References
involved_in protein O-linked glycosylation
inferred from biological aspect of ancestor with PANTHER:PTN002892972
(assigned by GO_Central )
(Gaudet et al., 2011)
Cellular Component (0 terms)
Terms Based on Experimental Evidence (0 terms)
Terms Based on Predictions or Assertions (0 terms)
Gene Group (FlyBase)
Pathway (FlyBase)
Protein Family (UniProt)
-
Protein Signatures (InterPro)
Catalytic Activity (EC)
Experimental Evidence
(1) UDP-N-acetyl-alpha-D-glucosamine + [protein]-L-serine = UDP + [protein]-3-O-(N-acetyl-beta-D-glucosaminyl)-L-serine (2.4.1.255)
(2) UDP-N-acetyl-alpha-D-glucosamine + [protein]-L-threonine = UDP + [protein]-3-O-(N-acetyl-beta-D-glucosaminyl)-L-threonine (2.4.1.255)
Predictions / Assertions
UDP-N-acetyl-D-glucosamine + [protein]-L-asparagine = UDP + [protein]- N(4)-(N-acetyl-D-glucosaminyl)-L-asparagine (2.4.1.94)
Summaries
Gene Snapshot
super sex combs (sxc) is a polycomb group gene that encodes a O-GlcNAc transferase involved in epigenetic gene silencing. [Date last reviewed: 2019-09-12]
Pathway (FlyBase)
Positive Regulators of FGFR Signaling Pathway -
Positive regulators of Fibroblast Growth Factor Receptor signaling up-regulate the pathway, enhancing the activation of ERK kinase (rl) or acting on other effectors.
Gene Group (FlyBase)
PROTEIN O-GLCNAC TRANSFERASES -
Protein O-GlcNAc transferases catalyze the transfer of N-acetylglucosamine (GlcNAc) from UDP-GlcNAc to the oxygen atom of serine/threonine hydroxyl groups of proteins. The OGT protein has this activity for intracellular proteins, while the EOGT protein specifically catalyzes O-GlcNAcetylation of EGF repeats on certain secreted/membrane proteins.
Phenotypic Description (Red Book; Lindsley and Zimm 1992)
sxc: super sex combs (P.W. Ingham)
Homozygous adults exhibit homeotic transformation of antenna to first leg, of second and third legs to first leg, of wing to haltere, and of abdominal segments A1, A4, and A5 to A2, A5, and A6, respectively. Homozygotes derived from homozygous female germ line exhibit transformation of larval thoracic and abdominal segments toward A8.
Gene Model and Products
Number of Transcripts
3
Number of Unique Polypeptides
1

Please see the JBrowse view of Dmel\sxc for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Structure New Section
Protein 3D structure   (Predicted by AlphaFold)   (AlphaFold entry Q7KJA9)

If you don't see the viewer to the right, refresh your browser.
Model Confidence:
  • Very high (pLDDT > 90)
  • Confident (90 > pLDDT > 70)
  • Low (70 > pLDDT > 50)
  • Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Comments on Gene Model

Low-frequency RNA-Seq exon junction(s) not annotated.

Gene model reviewed during 5.47

Sequence Ontology: Class of Gene
gene
nuclear_gene
protein_coding_gene
Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
sxc-RA
FBtr0086085
NM_165426
3557
1059
sxc-RB
FBtr0086084
NM_078896
3498
1059
sxc-RC
FBtr0086086
NM_165427
3678
1059
Additional Transcript Data and Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
RefSeq ID
GenBank
sxc-PA
FBpp0085421
118.6
1059
7.16
NP_724406
AAG22338
sxc-PB
FBpp0085420
118.6
1059
7.16
NP_523620
AAF57338
sxc-PC
FBpp0085422
118.6
1059
7.16
NP_724407
AAG22339
Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

1059 aa isoforms: sxc-PA, sxc-PB, sxc-PC
Additional Polypeptide Data and Comments
Reported size (kDa)
Comments
External Data
Crossreferences
InterPro - A database of protein families, domains and functional sites
Linkouts
Sequences Consistent with the Gene Model
Nucleotide / Polypeptide Records
 
UniProt
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\sxc using the Feature Mapper tool.

External Data
Crossreferences
Linkouts
Expression Data
Expression Summary Ribbons
Colored tiles in ribbon indicate that expression data has been curated by FlyBase for that anatomical location. Colorless tiles indicate that there is no curated data for that location.
For complete stage-specific expression data, view the modENCODE Development RNA-Seq section under High-Throughput Expression below.
Transcript Expression
Polypeptide Expression
mass spectroscopy
Stage
Tissue/Position (including subcellular localization)
Reference
adult stage
adult head
(Aradska et al., 2015)
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Evidence
References
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\sxc in GBrowse 2
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Bulk Downloads
RNA-Seq RPKM values for all genes
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
Flygut - An atlas of the Drosophila adult midgut
Images
FlyBase Wiki
Image Based Resources
Alleles, Insertions, Transgenic Constructs, and Aberrations
Classical and Insertion Alleles ( 15 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 20 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of sxc
Transgenic constructs containing regulatory region of sxc
Aberrations (Deficiencies and Duplications) ( 31 )
Inferred from experimentation ( 31 )
Gene disrupted in
Df(2R)M41A4
(Sinclair et al., 2009)
Df(2R)M41A8
(Gambetta and Müller, 2009.8.18, Gambetta et al., 2009, Sinclair et al., 2009, Myster et al., 2004)
Df(2R)nap1
(Gambetta and Müller, 2009.8.18, Gambetta et al., 2009, Myster et al., 2004)
Df(2R)nap4
(Gambetta and Müller, 2009.8.18)
Df(2R)nap8
(Gambetta and Müller, 2009.8.18)
Df(2R)NC13
(Myster et al., 2004, Myster and Peifer, 2003.9.11)
Df(2R)NC31
(Sinclair et al., 2009)
Df(2R)NC32
(Gambetta and Müller, 2009.8.18, Myster et al., 2004, Myster and Peifer, 2003.9.11)
Df(2R)NC50
(Myster et al., 2004)
Df(2R)NC68
(Myster et al., 2004)
Df(2R)NC73
(Myster et al., 2004, Myster and Peifer, 2003.9.11)
Df(2R)NC125
(Myster et al., 2004)
Df(2R)NC167
(Myster et al., 2004)
Df(2R)NC191
(Myster et al., 2004)
Df(2R)NC202
(Myster et al., 2004)
Df(2R)NC218
(Myster et al., 2004)
Df(2R)NC228
(Myster et al., 2004, Myster and Peifer, 2003.9.11)
Df(2R)Nipped-D263.3
(Sinclair et al., 2009)
Gene not disrupted in
Df(2R)244
(Myster et al., 2004)
Df(2R)247
(Myster et al., 2004)
Df(2R)Dark2
(Myster et al., 2004)
Df(2R)M41A2
(Myster et al., 2004)
Df(2R)M41A10
(Gambetta and Müller, 2009.8.18, Gambetta et al., 2009, Sinclair et al., 2009, Myster et al., 2004)
Df(2R)nap11
(Gambetta and Müller, 2009.8.18, Gambetta et al., 2009)
Df(2R)NC98
(Myster et al., 2004)
Df(2R)NC168
(Myster et al., 2004)
Df(2R)NC195
(Myster et al., 2004)
Df(2R)NC207
(Myster et al., 2004)
Df(2R)NC219
(Myster et al., 2004)
Df(2R)NC1198
(Myster et al., 2004)
Df(2R)Nipped-D
(Myster et al., 2004)
Inferred from location ( 0 )
Alleles Representing Disease-Implicated Variants
Phenotypes
For more details about a specific phenotype click on the relevant allele symbol.
Lethality
Allele
lethal
lethal, with Scer\GAL4Act5C.PU
lethal, with Scer\GAL4Tub.PU
lethal, with Scer\GAL4Tub.PU, sxc3
lethal, with Scer\GAL4Tub.PU, sxcdsRNA.Sym.UAS
lethal (with Df(2R)BSC630)
lethal (with sxc1)
lethal (with sxc3)
lethal (with sxc6)
lethal (with sxc02637)
lethal (with sxcK872M)
lethal | recessive
lethal - all die before end of larval stage | maternal effect, with Scer\GAL4Tub.PU, sxc6/sxc1
lethal - all die before end of larval stage | maternal effect (with sxc1), with Scer\GAL4Tub.PU, sxcD955A.UAS
lethal - all die before end of larval stage | maternal effect (with sxc6), with Scer\GAL4Tub.PU, sxcD955A.UAS
lethal - all die before end of larval stage | recessive
lethal - all die before end of P-stage (with Df(2R)nap1)
lethal - all die before end of P-stage (with sxc1)
lethal - all die before end of P-stage (with sxc3)
lethal - all die before end of P-stage (with sxc4)
lethal - all die before end of P-stage (with sxc5)
lethal - all die before end of P-stage (with sxc6)
lethal - all die before end of P-stage (with sxc7)
partially lethal - majority die, with Scer\GAL4pnr-MD237
partially lethal - majority die | female, with Scer\GAL4esg.PU
viable
viable, with Dcr-2UAS.cDa, Scer\GAL4elav.PLu
viable, with Scer\GAL4tin.CΔ4
viable (with sxc1)
viable (with sxc2)
viable (with sxc3)
viable (with sxc4)
viable (with sxc5)
viable (with sxc6)
viable (with sxc7)
viable (with sxcH537A)
viable (with sxcN595K-10.3)
viable (with sxcN595K-19.1)
Sterility
Allele
fertile (with sxc1)
fertile (with sxc2)
fertile (with sxc3)
fertile (with sxc4)
fertile (with sxc5)
fertile (with sxc6)
fertile (with sxc7)
Other Phenotypes
Allele
abnormal flight, with Scer\GAL4Mef2.PR
abnormal locomotor behavior | adult stage, with Scer\GAL4elav-C155
abnormal locomotor behavior | adult stage, with Scer\GAL4Mef2.PR
abnormal locomotor rhythm, with Scer\GAL4tim.UAS
abnormal locomotor rhythm | adult stage, with Scer\GAL4tim.UAS
decreased body size | adult stage, with Scer\GAL4Ilp2.PR
decreased body size | third instar larval stage, with Scer\GAL4Ilp2.PR
homeotic | embryonic stage | maternal effect
increased body size | adult stage, with Scer\GAL4Ilp2.PR
increased body size | third instar larval stage, with Scer\GAL4Ilp2.PR
increased mortality during development | temperature conditional
majority die during embryonic stage | maternal effect | heat sensitive, with Scer\GAL4da.G32, sxc1/sxc02637
majority die during embryonic stage | maternal effect | heat sensitive, with Scer\GAL4VP16.mat.αTub67C
majority die during embryonic stage | maternal effect | heat sensitive (with sxc1), with Scer\GAL4da.G32, sxcUAS.cSa
majority die during embryonic stage | maternal effect | heat sensitive (with sxc02637), with Scer\GAL4da.G32, sxcUAS.cSa
some die during larval stage | recessive
some die during pharate adult stage (with Df(2R)nap1)
some die during pharate adult stage (with sxc1)
some die during pharate adult stage (with sxc3)
some die during pharate adult stage (with sxc4)
some die during pharate adult stage (with sxc5)
some die during pharate adult stage (with sxc6)
some die during pharate adult stage (with sxc7)
some die during pupal stage, with Scer\GAL4pnr-MD237
visible, with Scer\GAL4pnr-MD237
visible, with Scer\GAL4Tub.PU, sxc6/sxc1
visible (with sxc1), with Scer\GAL4Tub.PU, sxcD955A.UAS
visible (with sxc1), with Scer\GAL4Tub.PU, sxcH537A.UAS
visible (with sxc1), with Scer\GAL4Tub.PU, sxcH596F.UAS
visible (with sxc1), with Scer\GAL4Tub.PU, sxcUAS.cMa
visible (with sxc6), with Scer\GAL4Tub.PU, sxcD955A.UAS
visible (with sxc6), with Scer\GAL4Tub.PU, sxcH537A.UAS
visible (with sxc6), with Scer\GAL4Tub.PU, sxcH596F.UAS
visible (with sxc6), with Scer\GAL4Tub.PU, sxcUAS.cMa
visible | adult stage, with Scer\GAL4esg.PU
Phenotype manifest in
Allele
abdominal segment 1
abdominal segment 4
abdominal segment 5
antenna
embryonic/first instar larval cuticle | maternal effect
larval abdominal segment 1
larval abdominal segment 2
larval abdominal segment 3
larval abdominal segment 4
larval abdominal segment 5
larval abdominal segment 6
larval abdominal segment 7
larval mesothoracic segment
larval metathoracic segment
larval prothoracic segment
mesothoracic leg
mesothoracic tergum, with Scer\GAL4pnr-MD237
metathoracic leg
posterior crossvein, with Scer\GAL4sd-SG29.1
sex comb | ectopic, with Scer\GAL4Tub.PU, sxc3
sex comb | ectopic, with Scer\GAL4Tub.PU, sxcdsRNA.Sym.UAS
wing
wing, with Scer\GAL4esg.PU
wing, with Scer\GAL4Tub.PU, sxc6/sxc1
wing (with sxc1)
wing (with sxc1), with Scer\GAL4Tub.PU, sxcD955A.UAS
wing (with sxc1), with Scer\GAL4Tub.PU, sxcH537A.UAS
wing (with sxc1), with Scer\GAL4Tub.PU, sxcH596F.UAS
wing (with sxc1), with Scer\GAL4Tub.PU, sxcUAS.cMa
wing (with sxc2)
wing (with sxc3)
wing (with sxc4)
wing (with sxc5)
wing (with sxc6)
wing (with sxc6), with Scer\GAL4Tub.PU, sxcD955A.UAS
wing (with sxc6), with Scer\GAL4Tub.PU, sxcH537A.UAS
wing (with sxc6), with Scer\GAL4Tub.PU, sxcH596F.UAS
wing (with sxc6), with Scer\GAL4Tub.PU, sxcUAS.cMa
wing (with sxc7)
wing vein, with Scer\GAL4A9
wing vein, with Scer\GAL4Bx-MS1096
wing vein | ectopic
wing vein | ectopic, with Scer\GAL4Tub.PU, sxc3/sxc02637
wing vein | ectopic, with Scer\GAL4Tub.PU, sxc6/sxc1
wing vein | ectopic (with sxc1), with Scer\GAL4Tub.PU, sxcD955A.UAS
wing vein | ectopic (with sxc1), with Scer\GAL4Tub.PU, sxcH537A.UAS
wing vein | ectopic (with sxc1), with Scer\GAL4Tub.PU, sxcH596F.UAS
wing vein | ectopic (with sxc1), with Scer\GAL4Tub.PU, sxcUAS.cMa
wing vein | ectopic (with sxc3), with Scer\GAL4Tub.PU, sxcUAS.cSa
wing vein | ectopic (with sxc6), with Scer\GAL4Tub.PU, sxcD955A.UAS
wing vein | ectopic (with sxc6), with Scer\GAL4Tub.PU, sxcH537A.UAS
wing vein | ectopic (with sxc6), with Scer\GAL4Tub.PU, sxcH596F.UAS
wing vein | ectopic (with sxc6), with Scer\GAL4Tub.PU, sxcUAS.cMa
wing vein | ectopic (with sxc02637), with Scer\GAL4Tub.PU, sxcUAS.cSa
Orthologs
Downloads
Download All DIOPT Orthologs
Human Orthologs (via DIOPT v8.0)
Homo sapiens (Human) (2)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
eggNOG
Hieranoid
Homologene
Inparanoid
Isobase
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
RoundUp
TreeFam
ZFIN
Alignment
Complementation?
Transgene?
Hsap\OGT
13 of 15
Yes
Yes
 
1  
Hsap\TTC13
1 of 15
No
Yes
Model Organism Orthologs (via DIOPT v8.0)
Mus musculus (laboratory mouse) (2)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
eggNOG
Hieranoid
Homologene
Inparanoid
Isobase
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
RoundUp
TreeFam
ZFIN
Alignment
Complementation?
Transgene?
Mmus\Ogt
13 of 15
Yes
Yes
Mmus\Ttc13
1 of 15
No
Yes
Rattus norvegicus (Norway rat) (2)
Rnor\Ogt
13 of 13
Yes
Yes
Rnor\Ttc13
1 of 13
No
Yes
Xenopus tropicalis (Western clawed frog) (2)
Xtro\ogt
8 of 12
Yes
Yes
Xtro\ttc13
1 of 12
No
Yes
Danio rerio (Zebrafish) (3)
Drer\ogt.2
11 of 15
Yes
Yes
Drer\ogt.1
10 of 15
No
Yes
Drer\ttc13
1 of 15
No
Yes
Caenorhabditis elegans (Nematode, roundworm) (1)
Cele\ogt-1
14 of 15
Yes
Yes
Arabidopsis thaliana (thale-cress) (2)
Atha\SEC
8 of 9
Yes
Yes
Atha\SPY
2 of 9
No
Yes
Saccharomyces cerevisiae (Brewer's yeast) (0)
No records found.
Schizosaccharomyces pombe (Fission yeast) (0)
No records found.
Other Organism Orthologs (via OrthoDB)
Paralogs
Downloads
Download All DIOPT Paralogs
Paralogs (via DIOPT v8.0)
Drosophila melanogaster (Fruit fly) (6)
Gene Symbol
Score
Source
Compara
eggNOG
Homologene
Inparanoid
Isobase
OrthoDB
OrthoFinder
orthoMCL
Panther
RoundUp
Alignment
BBS4
1 of 10
BBS8
1 of 10
CG4341
1 of 10
CG5038
1 of 10
CG31690
1 of 10
Tmtc3
1 of 10
Human Disease Associations
FlyBase Human Disease Model Reports
    Disease Model Summary Ribbon
    Disease Ontology (DO) Annotations
    Models Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Evidence
    References
    Potential Models Based on Orthology ( 1 )
    Modifiers Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Interaction
    References
    Disease Associations of Human Orthologs (via DIOPT v8.0 and OMIM)
    Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
    Homo sapiens (Human)
    Gene name
    Score
    OMIM
    OMIM Phenotype
    DO term
    Complementation?
    Transgene?
    OGT; O-linked N-acetylglucosamine (GlcNAc) transferase
    13 of 15
    300255
     
    Functional Complementation Data
    Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
    Dmel gene
    Ortholog showing functional complementation
    Supporting References
    sxc
    Hsap\OGT
    (Sinclair et al., 2009)
    Interactions
    Summary of Physical Interactions
    esyN Network Diagram
    Show neighbor-neighbor interactions:
    Select Layout:
    Legend:
    Protein
    RNA
    Selected Interactor(s)
    Interactions Browser
    View in Interactions Browser
    Please see the Physical Interaction reports below for full details
    protein-protein
    Physical Interaction
    Assay
    References
    sxc - Clk
    anti tag coimmunoprecipitation, anti tag western blot
    (Kaasik et al., 2013)
    sxc - Hipk
    anti bait coimmunoprecipitation, anti tag western blot, anti tag coimmunoprecipitation, western blot
    (Wong et al., 2020)
    Summary of Genetic Interactions
    esyN Network Diagram
    esyN Network Key:
    Suppression
    Enhancement
    View in Interactions Browser
    Please look at the allele data for full details of the genetic interactions
    Starting gene(s)
    Interaction type
    Interacting gene(s)
    Reference
    sxc
    enhanceable
    Hcf
    (Mariappa et al., 2018)
    Starting gene(s)
    Interaction type
    Interacting gene(s)
    Reference
    ash1|trx
    suppressible
    sxc
    (Gildea et al., 2000)
    brm|trx
    suppressible
    sxc
    (Gildea et al., 2000)
    E(z)
    suppressible
    sxc
    (Bajusz et al., 2001)
    Hcf
    enhanceable
    sxc
    (Mariappa et al., 2018)
    mxc
    enhanceable
    sxc
    (Saget et al., 1998)
    nst
    suppressible
    sxc
    (Mariappa et al., 2011)
    Pc
    enhanceable
    sxc
    (Mariappa et al., 2018)
    skd
    enhanceable
    sxc
    (Mariappa et al., 2018)
    trx|brm
    enhanceable
    sxc
    (Gildea et al., 2000)
    trx|ash1
    enhanceable
    sxc
    (Gildea et al., 2000)
    External Data
    Linkouts
    BioGRID - A database of protein and genetic interactions.
    DroID - A comprehensive database of gene and protein interactions.
    MIST (genetic) - An integrated Molecular Interaction Database
    MIST (protein-protein) - An integrated Molecular Interaction Database
    Pathways
    Signaling Pathways (FlyBase)
    Positive Regulators of FGFR Signaling Pathway -
    Positive regulators of Fibroblast Growth Factor Receptor signaling up-regulate the pathway, enhancing the activation of ERK kinase (rl) or acting on other effectors.
    Metabolic Pathways
    FlyMet - A comprehensive tissue-specific metabolomics resource for Drosophila.
    External Data
    Linkouts
    KEGG Pathways - Wiring diagrams of molecular interactions, reactions and relations.
    Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
    Genomic Location and Detailed Mapping Data
    Chromosome (arm)
    2R
    Recombination map
    2-55
    Cytogenetic map
    41C1-41C2
    Sequence location
    FlyBase Computed Cytological Location
    Cytogenetic map
    Evidence for location
    41C1-41C2
    Left limit from inclusion within Df(2R)M41A4 (citation unavailable) Right limit from inclusion within Df(2R)M41A4 (citation unavailable)
    Experimentally Determined Cytological Location
    Cytogenetic map
    Notes
    References
    Experimentally Determined Recombination Data
    Location

    2-55

    (FlyBase, 2016)

    2-55.5

    (Comeron et al., 2012)

    2-55.3

    Left of (cM)
    Right of (cM)
    Notes
    Stocks and Reagents
    Stocks (17)
    Genomic Clones (31)
    cDNA Clones (255)
     

    Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

    cDNA clones, fully sequenced
    BDGP DGC clones
    Other clones
      Drosophila Genomics Resource Center cDNA clones

      For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

      cDNA Clones, End Sequenced (ESTs)
      BDGP DGC clones
      Other clones
      RNAi and Array Information
      Linkouts
      DRSC - Results frm RNAi screens
      GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
      Antibody Information
      Laboratory Generated Antibodies
       

      polyclonal

      (Liu et al., 2021)
      Commercially Available Antibodies
       
      Other Information
      Relationship to Other Genes
      Source for database identify of
      Source for database merge of

      Source for merge of: sxc l(2)NC130

      (Gambetta et al., 2009)

      Source for merge of: Ogt BcDNA:GH04245

      (Bayraktaroglu, 2000.8.7)

      Source for merge of: sxc Ogt

      (Gambetta et al., 2009)
      Additional comments

      FlyBase Curator comment: Added "l(2)02637" symbol synonym to sxc as FBrf0209489 states that the lethality associated with the "l(2)02637" line is caused by a second lesion, the Transpac{}sxc02637 insertion, in the sxc gene and not the P{PZ}L02637 insertion in the L gene.

      Other Comments

      Identification: During an EMS mutagenesis for lethal mutations uncovered by Df(2R)M41A8.

      (Myster et al., 2004)

      Mutant analysis demonstrates functional interactions between Pc, sxc and Asx in vivo.

      (Milne et al., 1999)

      In an effort to subdivide the Pc-group genes functionally, the phenotypes of adult flies heterozygous for every pairwise combination of Pc-group mutation were examined. Genetic interactions have been demonstrated between esc, Asx, E(Pc), Pcl, E(z) and sxc. Most duplications of Pc-group genes neither exhibit anterior transformations nor suppress the extra sex comb phenotype of Pc-group mutations, suggesting that not all Pc-group genes behave as predicted by the mass action model.

      (Campbell et al., 1995)

      Sections of the Scr regulatory region may be important for regulation of Scr by Polycomb- and trithorax-group genes.

      (Gindhart and Kaufman, 1995)

      The Pc group genes are negative regulators of homeotic genes.

      (McKeon and Brock, 1991)
      Origin and Etymology
      Discoverer
      Etymology
      Identification
      External Crossreferences and Linkouts ( 57 )
      Sequence Crossreferences
      NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
      GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
      GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
      RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
      UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.
      UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information
      Other crossreferences
      AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.
      BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
      Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones
      DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
      EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
      FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
      FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
      Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
      Flygut - An atlas of the Drosophila adult midgut
      FlyMet - A comprehensive tissue-specific metabolomics resource for Drosophila.
      FlyMine - An integrated database for Drosophila genomics
      GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
      iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)
      InterPro - A database of protein families, domains and functional sites
      KEGG Genes - Molecular building blocks of life in the genomic space.
      MARRVEL_MODEL - MARRVEL (model organism gene)
      modMine - A data warehouse for the modENCODE project
      SignaLink - A signaling pathway resource with multi-layered regulatory networks.
      Linkouts
      BioGRID - A database of protein and genetic interactions.
      DroID - A comprehensive database of gene and protein interactions.
      DRSC - Results frm RNAi screens
      KEGG Pathways - Wiring diagrams of molecular interactions, reactions and relations.
      MIST (genetic) - An integrated Molecular Interaction Database
      MIST (protein-protein) - An integrated Molecular Interaction Database
      Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
      Synonyms and Secondary IDs (19)
      Reported As
      Symbol Synonym
      BcDNA:GH04245
      CG10392
      (Cotsworth et al., 2022, Yamamoto-Hino et al., 2015, Kaasik et al., 2013, Ni et al., 2010.12.1, Gambetta et al., 2009, Gambetta et al., 2009, Keleman et al., 2009.8.5, Rossi et al., 2007, Labourier et al., 2002)
      DmOGT
      (Mariappa et al., 2015)
      OGT
      (Lam Wong and Verheyen, 2021, Zhao et al., 2021, Li et al., 2020, May et al., 2020, Na et al., 2020, Patke et al., 2020, May et al., 2019, Zhang and Ten Hagen, 2019, Liu et al., 2017, Na et al., 2015, Tataroglu and Emery, 2015, Zhang and Baehrecke, 2015, Na et al., 2013, Mariappa et al., 2011, Park et al., 2011, Matsuura et al., 2008, Jínek et al., 2004)
      Ogt
      (Cotsworth et al., 2022, Nishihara, 2020, Pamudurti et al., 2020, Mattila and Hietakangas, 2017, Akan et al., 2016, Nässel and Vanden Broeck, 2016, Bajusz et al., 2015, Nässel et al., 2015, Ashwal-Fluss et al., 2014, McElroy et al., 2014, Radermacher et al., 2014, Radermacher et al., 2014, Kaasik et al., 2013, Sekine et al., 2010, Gambetta et al., 2009, Sinclair et al., 2009, Sinclair et al., 2009, Liu and Lehmann, 2008, Yasuhara and Wakimoto, 2008, Stuart et al., 2007, Badal et al., 2006, Stanyon et al., 2004)
      P1201
      (Dickson et al., 1995)
      SXC
      (Ma et al., 2021, Liu et al., 2017, Schwartz and Pirrotta, 2007)
      Sxc
      (Yamamoto-Hino et al., 2015, McElroy et al., 2014, Rincon-Arano et al., 2012, Gildea et al., 2000)
      dO-GnT
      (Yamamoto-Hino et al., 2015)
      l(2)02637
      (Spradling et al., 1999, Jackle and Janning, 1998.8.10)
      l(2)NC130
      (Gambetta and Müller, 2009.8.18, Gambetta et al., 2009)
      ogt
      (Akan et al., 2021, Liu et al., 2021, Wong et al., 2020, Li et al., 2019, Akan et al., 2018, Park et al., 2015, Gambetta and Müller, 2014, Na et al., 2013)
      sxc
      (Moulton et al., 2020, Wong et al., 2020, Decourcelle et al., 2019, Honda and Sinclair, 2019.10.21, Liu et al., 2019, May et al., 2019, Pravata et al., 2019, Akan et al., 2018, Lee et al., 2018, Selvan et al., 2017, Akan et al., 2016, Gene Disruption Project members, 2016-, Bajusz et al., 2015, Mariappa et al., 2015, Gambetta and Müller, 2014, Radermacher et al., 2014, Müller et al., 2013, Na et al., 2013, Mariappa et al., 2011, Ashton-Beaucage et al., 2010, Gambetta and Müller, 2009.8.18, Gambetta et al., 2009, Gambetta et al., 2009, Sinclair et al., 2009, Sinclair et al., 2009, Hirose et al., 2001)
      sxc/Ogt
      (Gambetta and Müller, 2009.8.18, Gambetta et al., 2009)
      Name Synonyms
      O-GlcNAc transferase
      (Nishihara, 2020, Mattila and Hietakangas, 2017, Akan et al., 2016, Mariappa et al., 2015)
      O-glycosyltransferase
      (Zhang et al., 2008, Rubenstein, 1999.12.20)
      O-linked N-acetylglucosamine transferase
      (Gambetta et al., 2009)
      lethal (2) NC130
      super sex combs
      (Mattila and Hietakangas, 2017, Mariappa et al., 2015, Mariappa et al., 2015, Mariappa et al., 2011, Gambetta et al., 2009, Sinclair et al., 2009)
      Secondary FlyBase IDs
      • FBgn0067375
      • FBgn0003658
      • FBgn0261392
      • FBgn0040295
      • FBan0010392
      • FBgn0027591
      Datasets (8)
      Study focus (0)
      Experimental Role
      Project
      Project Type
      Title
      Study result (8)
      Result
      Result Type
      Title
      scRNAseq_2020_Cattenoz_NI_seq_clustering
      Clustering analysis of hemocytes from non-infested third instar larvae
      scRNAseq_2020_Cattenoz_WI_seq_clustering
      Clustering analysis of hemocytes from wasp-infested third instar larvae
      scRNAseq_2020_Cho_NI72LG_seq_clustering
      Clustering analysis of lymph gland cells from non-infested larvae at 72 h after egg-laying
      scRNAseq_2020_Cho_NI96LG_seq_clustering
      Clustering analysis of lymph gland cells from non-infested larvae at 96 h after egg-laying
      scRNAseq_2020_Cho_NI120LG_seq_clustering
      Clustering analysis of lymph gland cells from non-infested larvae at 120 h after egg-laying
      scRNAseq_2020_Cho_WI96LG_seq_clustering
      Clustering analysis of lymph gland cells from wasp-infested larvae at 96 h after egg-laying
      scRNAseq_2020_Cho_NI96HL_seq_clustering
      Clustering analysis of circulating hemocytes from non-infested larvae at 96 h after egg-laying
      scRNAseq_2020_Cho_NI120HL_seq_clustering
      Clustering analysis of circulating hemocytes from non-infested larvae at 120 h after egg-laying
      References (142)