Please see the JBrowse view of Dmel\CSN8 for information on other features
To submit a correction to a gene model please use the Contact FlyBase form
AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.
Low-frequency RNA-Seq exon junction(s) not annotated.
Gene model reviewed during 5.50
There is only one protein coding transcript and one polypeptide associated with this gene
156 (aa)
Essential component of the CSN complex, probably composed of CSN1b, alien/CSN2, CSN3, CSN4, CSN5, CSN6, CSN7 and CSN8.
The PCI domain is necessary and sufficient for interactions with other CSN subunits of the complex.
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\CSN8 using the Feature Mapper tool.
The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).
JBrowse - Visual display of RNA-Seq signals
View Dmel\CSN8 in JBrowse2-31
2-27.7
Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
polyclonal
3 alleles of l(2)SH1829 recovered in a P-insertion screen.
Identification: On the basis of sequence similarity to COP9 signalosome units.
COP9 signalosome is essential for development.
Source for merge of: CSN8 l(2)SH1829
The symbol "CG13383" has been used erroneously in FlyBase to name 2 adjacent annotations in different releases of the genome annotation. The two annotations represent the CSN8 and Pp2A-29B genes. In release 2 of the genome annotation, the "CG13383" annotation corresponded to the CSN8 open reading frame (ORF), and the annotation corresponding to Pp2A-29B was labelled "CG17291". In release 3.1 of the genome annotation, the "CG13383" annotation corresponded to the Pp2A-29B open reading frame (ORF). In release 3.2 of the genome annotation, the two genes were annotated as part of a dicistronic transcript represented by the "CG33297" annotation. In release 5.1 of the genome annotation, the two genes were annotated as monocistronic transcripts, as there was no longer sufficient evidence to support a processed dicistronic transcript, with the annotation representing the Pp2A-29B gene being labelled "CG17291" and the annotation representing the CSN8 gene being labelled "CG13383". Since the "CG13383" symbol has been used for two different annotations, the annotation for the CSN8 gene has been renamed to "CG42522" in release 5.13 of the genome annotation to avoid confusion.
RT-PCR analysis of CSN8 and Pp2A-29B transcription provides no evidence that a dicistronic transcript containing both open reading frames is produced. Thus it is concluded that CSN8 is transcribed independently of Pp2A-29B and that a dicistronic transcript is unlikely or is present at undetectable levels.
CSN8 and Pp2A-29B were annotated as being non-overlapping open reading frames derived from a processed dicistronic transcript in release 3.2 of the genome based on the LD10247 cDNA. However, this clone appears to be problematic and there is no longer sufficient evidence to support a processed dicistronic transcript, thus CSN8 and Pp2A-29B have been annotated as genes encoded by monocistronic transcripts in release 5.1 of the genome annotation.
