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Gene Dmel\CSN8

General Information
Symbol	Dmel\CSN8	Species	D. melanogaster
Name	COP9 complex homolog subunit 8	Annotation symbol	CG42522
Feature type	protein_coding_gene	FlyBase ID	FBgn0261437
Gene Model Status	Current	Stock availability	1 publicly available
Also Known As	CG13383
Genomic Location
Chromosome (arm)	2L	Recombination map
Cytogenetic map	29B2-29B2	Sequence location	2L:8,364,855..8,365,663 [+]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents Beta	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene COP9 complex homolog subunit 8 is referred to in FlyBase by the symbol Dmel\CSN8 (CG42522, FBgn0261437). It is a protein_coding_gene from Drosophila melanogaster. Its molecular function is unknown. There is experimental evidence that it is involved in the biological process: protein stabilization; mitotic G2 DNA damage checkpoint; defense response to bacterium; oogenesis; imaginal disc-derived wing morphogenesis; compound eye morphogenesis. 7 alleles are reported. No phenotypic data is available. It has one annotated transcript and one annotated polypeptide. Protein features are: COP9 signalosome, subunit CSN8. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of moderate expression. Peak expression observed within 00-18 hour embryonic stages. This gene is annotated by FlyBase as a dicistronic gene, meaning that some or all of its transcripts encode two or more polypeptide-coding open reading frames (ORFs) , with each ORF assigned to a different gene. The distribution of RNA-Seq coverage data amongst the different encoded genes cannot be determined. Summary of FlyAtlas Anatomical Expression Data: High or moderate levels of expression observed in all larval and adult organs/tissues. Expression at high levels in the following post-embryonic organs or tissues: larval central nervous system, adult ovary. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, adult eye, adult central nervous system, adult crop, larval/adult midgut, larval/adult hindgut, larval/adult Malpighian tubules, adult heart, larval/adult fat body, larval/adult salivary gland, larval trachea, adult spermathecae, adult male reproductive system, larval/adult carcass. Comments on Affy2 ProbeSet: ProbeSet 1624894_s_at partially aligns to an exonic region of the only FlyBase-annotated transcript isoform of CSN8: 11 out of 14 probes fall into this exonic region. Gene sequence location is 2L:8364855..8365663.
User Contributed Data
	Beta version, feedback welcome
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
Update Feed	Click the icon below to subscribe to this FlyBase record and receive updates automatically through your feed reader.
FB2013_03	Controlled Vocabulary Terms regulation of cell cycle
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 29B2-29B2   Limits computationally determined from genome sequence between P{EP}EP646EP646&P{lacW}RpS13k09614 and P{lacW}l(2)k12914k12914&P{lacW}Akap200k07118a
Experimentally Determined Cytological Location
Cytogenetic map Notes References 29A1-29A2     (Oh et al., 2003)
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\CSN8 for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
	Gene model reviewed during 5.50 Low-frequency RNA-Seq exon junction(s) not annotated.
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) CSN8-RB FBtr0079646  NM_164809   641   182
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein CSN8-PB   FBpp0079262   21.4   182   4.52     NP_723378   AAN10662
Additional Polypeptide Data & Comments
Reported size (kDa)	156 (aa) (Freilich et al., 1999)
Comments
External Data
Linkouts
Crossreferences
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA391357   AE014134 AAN10662   AB082663   AW942119   BP550752   BP550753   BT011518   BT021405   EV580725   EV599532
UniProtKB/Swiss-Prot	Q7KTH8
UniProtKB/TrEMBL
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
in situ Stage Tissue/Position (including subcellular localization) Reference embryonic stage 1 -- 3   organism | ubiquitous   (Fisher et al., 2012) Comment:maternally deposited embryonic stage 4 -- 6   organism | ubiquitous   (Fisher et al., 2012) embryonic stage 7 -- 8   organism | ubiquitous   (Fisher et al., 2012) embryonic stage 9 -- 10   organism | ubiquitous   (Fisher et al., 2012) embryonic stage 11 -- 12   organism | ubiquitous   (Fisher et al., 2012) embryonic stage 13 -- 16   organism | ubiquitous   (Fisher et al., 2012) RT-PCR Stage Tissue/Position (including subcellular localization) Reference embryonic stage   organism   (Oren-Giladi et al., 2008) first instar larval stage   organism   (Oren-Giladi et al., 2008) second instar larval stage   organism   (Oren-Giladi et al., 2008) third instar larval stage   organism   (Oren-Giladi et al., 2008) adult stage   organism   (Oren-Giladi et al., 2008)
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Polypeptide Expression
mass spectroscopy Stage Tissue/Position (including subcellular localization) Reference day 7 of adulthood -- day 49 of adulthood   adult heart   (Cammarato et al., 2011) western blot Stage Tissue/Position (including subcellular localization) Reference embryonic stage   organism   (Oren-Giladi et al., 2008) first instar larval stage   organism   (Oren-Giladi et al., 2008) second instar larval stage   organism   (Oren-Giladi et al., 2008) third instar larval stage   organism   (Oren-Giladi et al., 2008) pupal stage   organism   (Oren-Giladi et al., 2008) adult stage   organism   (Oren-Giladi et al., 2008) unfertilized egg stage   organism   (Oren-Giladi et al., 2008)
Additional Descriptive Data
Marker for
Subcellular Localization (GO Cellular Component)
CV term Evidence References
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools
Reference	See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes.
FlyAtlas Anatomy Microarray
FlyAtlas Anatomical Expression Data (FlyAtlas-RNA.adult) (FlyAtlas-RNA.larva)    Styles Linear Logarithmic Heatmap Back-to-back    Scales gene max expression Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: High or moderate levels of expression observed in all larval and adult organs/tissues. Expression at high levels in the following post-embryonic organs or tissues: larval central nervous system, adult ovary. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, adult eye, adult central nervous system, adult crop, larval/adult midgut, larval/adult hindgut, larval/adult Malpighian tubules, adult heart, larval/adult fat body, larval/adult salivary gland, larval trachea, adult spermathecae, adult male reproductive system, larval/adult carcass. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (>999.999) Linear, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    612.5 Larval Midgut    276.5 Larval Hindgut    271.3 Larval Malpighian Tubules    372 Larval Fat Body    320 Larval Salivary Gland    369.2 Larval Trachea    486.95 Larval Carcass    312.525 Adult Head    269.2 Adult Eye    383.025 Adult Brain    227.4 Adult Thoracic-Abdominal Ganglion    249.4 Adult Crop    277.2 Adult Midgut    238.2 Adult Hindgut    180.7 Adult Malpighian Tubules    259.2 Adult Fat Body    237.8 Adult Salivary Gland    235.5 Adult Heart    304.975 Adult VirginFemale Spermatheca    408.6 Adult InseminatedFemale Spermatheca    412.1 Adult Ovary    550.3 Adult Testis    134.3 Adult Male Accessory Gland    257.5 Adult Carcass    184.6 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System  (612.5) Larval Midgut    276.5 Larval Hindgut    271.3 Larval Malpighian Tubules    372 Larval Fat Body    320 Larval Salivary Gland    369.2 Larval Trachea    486.95 Larval Carcass    312.525 Adult Head    269.2 Adult Eye    383.025 Adult Brain    227.4 Adult Thoracic-Abdominal Ganglion    249.4 Adult Crop    277.2 Adult Midgut    238.2 Adult Hindgut    180.7 Adult Malpighian Tubules    259.2 Adult Fat Body    237.8 Adult Salivary Gland    235.5 Adult Heart    304.975 Adult VirginFemale Spermatheca    408.6 Adult InseminatedFemale Spermatheca    412.1 Adult Ovary  (550.3) Adult Testis    134.3 Adult Male Accessory Gland    257.5 Adult Carcass    184.6 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    612.5 Larval Midgut    276.5 Larval Hindgut    271.3 Larval Malpighian Tubules    372 Larval Fat Body    320 Larval Salivary Gland    369.2 Larval Trachea    486.95 Larval Carcass    312.525 Adult Head    269.2 Adult Eye    383.025 Adult Brain    227.4 Adult Thoracic-Abdominal Ganglion    249.4 Adult Crop    277.2 Adult Midgut    238.2 Adult Hindgut    180.7 Adult Malpighian Tubules    259.2 Adult Fat Body    237.8 Adult Salivary Gland    235.5 Adult Heart    304.975 Adult VirginFemale Spermatheca    408.6 Adult InseminatedFemale Spermatheca    412.1 Adult Ovary    550.3 Adult Testis    134.3 Adult Male Accessory Gland    257.5 Adult Carcass    184.6 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    612.5 Larval Midgut    276.5 Larval Hindgut    271.3 Larval Malpighian Tubules    372 Larval Fat Body    320 Larval Salivary Gland    369.2 Larval Trachea    486.95 Larval Carcass    312.525 Adult Head    269.2 Adult Eye    383.025 Adult Brain    227.4 Adult Thoracic-Abdominal Ganglion    249.4 Adult Crop    277.2 Adult Midgut    238.2 Adult Hindgut    180.7 Adult Malpighian Tubules    259.2 Adult Fat Body    237.8 Adult Salivary Gland    235.5 Adult Heart    304.975 Adult VirginFemale Spermatheca    408.6 Adult InseminatedFemale Spermatheca    412.1 Adult Ovary    550.3 Adult Testis    134.3 Adult Male Accessory Gland    257.5 Adult Carcass    184.6 Expression Level Scale  Very high  log, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    612.5 Larval Midgut    276.5 Larval Hindgut    271.3 Larval Malpighian Tubules    372 Larval Fat Body    320 Larval Salivary Gland    369.2 Larval Trachea    486.95 Larval Carcass    312.525 Adult Head    269.2 Adult Eye    383.025 Adult Brain    227.4 Adult Thoracic-Abdominal Ganglion    249.4 Adult Crop    277.2 Adult Midgut    238.2 Adult Hindgut    180.7 Adult Malpighian Tubules    259.2 Adult Fat Body    237.8 Adult Salivary Gland    235.5 Adult Heart    304.975 Adult VirginFemale Spermatheca    408.6 Adult InseminatedFemale Spermatheca    412.1 Adult Ovary    550.3 Adult Testis    134.3 Adult Male Accessory Gland    257.5 Adult Carcass    184.6 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System  612.5 Larval Midgut    276.5 Larval Hindgut    271.3 Larval Malpighian Tubules    372 Larval Fat Body    320 Larval Salivary Gland    369.2 Larval Trachea    486.95 Larval Carcass    312.525 Adult Head    269.2 Adult Eye    383.025 Adult Brain    227.4 Adult Thoracic-Abdominal Ganglion    249.4 Adult Crop    277.2 Adult Midgut    238.2 Adult Hindgut    180.7 Adult Malpighian Tubules    259.2 Adult Fat Body    237.8 Adult Salivary Gland    235.5 Adult Heart    304.975 Adult VirginFemale Spermatheca    408.6 Adult InseminatedFemale Spermatheca    412.1 Adult Ovary  550.3 Adult Testis    134.3 Adult Male Accessory Gland    257.5 Adult Carcass    184.6 Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    612.5 Larval Midgut    276.5 Larval Hindgut    271.3 Larval Malpighian Tubules    372 Larval Fat Body    320 Larval Salivary Gland    369.2 Larval Trachea    486.95 Larval Carcass    312.525 Adult Head    269.2 Adult Eye    383.025 Adult Brain    227.4 Adult Thoracic-Abdominal Ganglion    249.4 Adult Crop    277.2 Adult Midgut    238.2 Adult Hindgut    180.7 Adult Malpighian Tubules    259.2 Adult Fat Body    237.8 Adult Salivary Gland    235.5 Adult Heart    304.975 Adult VirginFemale Spermatheca    408.6 Adult InseminatedFemale Spermatheca    412.1 Adult Ovary    550.3 Adult Testis    134.3 Adult Male Accessory Gland    257.5 Adult Carcass    184.6 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    612.5 Larval Midgut    276.5 Larval Hindgut    271.3 Larval Malpighian Tubules    372 Larval Fat Body    320 Larval Salivary Gland    369.2 Larval Trachea    486.95 Larval Carcass    312.525 Adult Head    269.2 Adult Eye    383.025 Adult Brain    227.4 Adult Thoracic-Abdominal Ganglion    249.4 Adult Crop    277.2 Adult Midgut    238.2 Adult Hindgut    180.7 Adult Malpighian Tubules    259.2 Adult Fat Body    237.8 Adult Salivary Gland    235.5 Adult Heart    304.975 Adult VirginFemale Spermatheca    408.6 Adult InseminatedFemale Spermatheca    412.1 Adult Ovary    550.3 Adult Testis    134.3 Adult Male Accessory Gland    257.5 Adult Carcass    184.6 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    269.2   NA  Eye    383.025   NA  Brain    227.4   612.5  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    249.4   NA  Crop    277.2   276.5  Midgut    238.2   271.3  Hindgut    180.7   372  Malpighian Tubules    259.2   320  Fat Body    237.8   369.2  Salivary Gland    235.5   NA  Heart    304.975   486.95  Trachea    NA   NA  VirginFemale Spermatheca    408.6   NA  InseminatedFemale Spermatheca    412.1   NA  Ovary    550.3   NA  Testis    134.3   NA  Male Accessory Gland    257.5   312.525  Carcass    184.6 FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
modENCODE Anatomy RNA-Seq
modENCODE Tissue Expression Data (modENCODE_mRNA-Seq_tissues)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    28 central nervous system, larvae L3    32 central nervous system, pupae P8    26 head, virgin 1-day female    14 head, virgin 4-day female    14 head, virgin 20-day female    8 head, mated 1-day female    9 head, mated 4-day female    12 head, mated 20-day female    8 head, mated 1-day male    14 head, mated 4-day male    16 head, mated 20-day male    21 salivary gland, larvae L3 wandering    7 salivary gland, white prepupae    15 digestive system, larvae L3 wandering    20 digestive system, 1-day adult    15 digestive system, 4-day adult    16 digestive system, 20-day adult    11 fat body, larvae L3 wandering    6 fat body, white prepupae    15 fat body, pupae P8    9 carcass, larvae L3 wandering    22 carcass, 1-day adult    8 carcass, 4-day adult    9 carcass, 20-day adult    6 ovary, virgin 4-day female    47 ovary, mated 4-day female    41 testis, mated 4-day male    13 accessory gland, mated 4-day male    9 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  Linear, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering  (28) central nervous system, larvae L3  (32) central nervous system, pupae P8  26 head, virgin 1-day female    14 head, virgin 4-day female    14 head, virgin 20-day female    8 head, mated 1-day female    9 head, mated 4-day female    12 head, mated 20-day female    8 head, mated 1-day male    14 head, mated 4-day male    16 head, mated 20-day male    21 salivary gland, larvae L3 wandering    7 salivary gland, white prepupae    15 digestive system, larvae L3 wandering    20 digestive system, 1-day adult    15 digestive system, 4-day adult    16 digestive system, 20-day adult    11 fat body, larvae L3 wandering    6 fat body, white prepupae    15 fat body, pupae P8    9 carcass, larvae L3 wandering    22 carcass, 1-day adult    8 carcass, 4-day adult    9 carcass, 20-day adult    6 ovary, virgin 4-day female  (47) ovary, mated 4-day female  (41) testis, mated 4-day male    13 accessory gland, mated 4-day male    9 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    28 central nervous system, larvae L3    32 central nervous system, pupae P8    26 head, virgin 1-day female    14 head, virgin 4-day female    14 head, virgin 20-day female    8 head, mated 1-day female    9 head, mated 4-day female    12 head, mated 20-day female    8 head, mated 1-day male    14 head, mated 4-day male    16 head, mated 20-day male    21 salivary gland, larvae L3 wandering    7 salivary gland, white prepupae    15 digestive system, larvae L3 wandering    20 digestive system, 1-day adult    15 digestive system, 4-day adult    16 digestive system, 20-day adult    11 fat body, larvae L3 wandering    6 fat body, white prepupae    15 fat body, pupae P8    9 carcass, larvae L3 wandering    22 carcass, 1-day adult    8 carcass, 4-day adult    9 carcass, 20-day adult    6 ovary, virgin 4-day female    47 ovary, mated 4-day female    41 testis, mated 4-day male    13 accessory gland, mated 4-day male    9 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    28 central nervous system, larvae L3    32 central nervous system, pupae P8    26 head, virgin 1-day female    14 head, virgin 4-day female    14 head, virgin 20-day female    8 head, mated 1-day female    9 head, mated 4-day female    12 head, mated 20-day female    8 head, mated 1-day male    14 head, mated 4-day male    16 head, mated 20-day male    21 salivary gland, larvae L3 wandering    7 salivary gland, white prepupae    15 digestive system, larvae L3 wandering    20 digestive system, 1-day adult    15 digestive system, 4-day adult    16 digestive system, 20-day adult    11 fat body, larvae L3 wandering    6 fat body, white prepupae    15 fat body, pupae P8    9 carcass, larvae L3 wandering    22 carcass, 1-day adult    8 carcass, 4-day adult    9 carcass, 20-day adult    6 ovary, virgin 4-day female    47 ovary, mated 4-day female    41 testis, mated 4-day male    13 accessory gland, mated 4-day male    9 Expression Level Scale  Extremely high  log, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    28 central nervous system, larvae L3    32 central nervous system, pupae P8    26 head, virgin 1-day female    14 head, virgin 4-day female    14 head, virgin 20-day female    8 head, mated 1-day female    9 head, mated 4-day female    12 head, mated 20-day female    8 head, mated 1-day male    14 head, mated 4-day male    16 head, mated 20-day male    21 salivary gland, larvae L3 wandering    7 salivary gland, white prepupae    15 digestive system, larvae L3 wandering    20 digestive system, 1-day adult    15 digestive system, 4-day adult    16 digestive system, 20-day adult    11 fat body, larvae L3 wandering    6 fat body, white prepupae    15 fat body, pupae P8    9 carcass, larvae L3 wandering    22 carcass, 1-day adult    8 carcass, 4-day adult    9 carcass, 20-day adult    6 ovary, virgin 4-day female    47 ovary, mated 4-day female    41 testis, mated 4-day male    13 accessory gland, mated 4-day male    9 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  log, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering  28 central nervous system, larvae L3  32 central nervous system, pupae P8  26 head, virgin 1-day female    14 head, virgin 4-day female    14 head, virgin 20-day female    8 head, mated 1-day female    9 head, mated 4-day female    12 head, mated 20-day female    8 head, mated 1-day male    14 head, mated 4-day male    16 head, mated 20-day male    21 salivary gland, larvae L3 wandering    7 salivary gland, white prepupae    15 digestive system, larvae L3 wandering    20 digestive system, 1-day adult    15 digestive system, 4-day adult    16 digestive system, 20-day adult    11 fat body, larvae L3 wandering    6 fat body, white prepupae    15 fat body, pupae P8    9 carcass, larvae L3 wandering    22 carcass, 1-day adult    8 carcass, 4-day adult    9 carcass, 20-day adult    6 ovary, virgin 4-day female  (47) ovary, mated 4-day female  (41) testis, mated 4-day male    13 accessory gland, mated 4-day male    9 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    28 central nervous system, larvae L3    32 central nervous system, pupae P8    26 head, virgin 1-day female    14 head, virgin 4-day female    14 head, virgin 20-day female    8 head, mated 1-day female    9 head, mated 4-day female    12 head, mated 20-day female    8 head, mated 1-day male    14 head, mated 4-day male    16 head, mated 20-day male    21 salivary gland, larvae L3 wandering    7 salivary gland, white prepupae    15 digestive system, larvae L3 wandering    20 digestive system, 1-day adult    15 digestive system, 4-day adult    16 digestive system, 20-day adult    11 fat body, larvae L3 wandering    6 fat body, white prepupae    15 fat body, pupae P8    9 carcass, larvae L3 wandering    22 carcass, 1-day adult    8 carcass, 4-day adult    9 carcass, 20-day adult    6 ovary, virgin 4-day female    47 ovary, mated 4-day female    41 testis, mated 4-day male    13 accessory gland, mated 4-day male    9 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    28 central nervous system, larvae L3    32 central nervous system, pupae P8    26 head, virgin 1-day female    14 head, virgin 4-day female    14 head, virgin 20-day female    8 head, mated 1-day female    9 head, mated 4-day female    12 head, mated 20-day female    8 head, mated 1-day male    14 head, mated 4-day male    16 head, mated 20-day male    21 salivary gland, larvae L3 wandering    7 salivary gland, white prepupae    15 digestive system, larvae L3 wandering    20 digestive system, 1-day adult    15 digestive system, 4-day adult    16 digestive system, 20-day adult    11 fat body, larvae L3 wandering    6 fat body, white prepupae    15 fat body, pupae P8    9 carcass, larvae L3 wandering    22 carcass, 1-day adult    8 carcass, 4-day adult    9 carcass, 20-day adult    6 ovary, virgin 4-day female    47 ovary, mated 4-day female    41 testis, mated 4-day male    13 accessory gland, mated 4-day male    9 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Tissue   Expression Level imaginal disc, larvae L3 wandering     central nervous system, larvae L3     central nervous system, pupae P8     head, virgin 1-day female     head, virgin 4-day female     head, virgin 20-day female     head, mated 1-day female     head, mated 4-day female     head, mated 20-day female     head, mated 1-day male     head, mated 4-day male     head, mated 20-day male     salivary gland, larvae L3 wandering     salivary gland, white prepupae     digestive system, larvae L3 wandering     digestive system, 1-day adult     digestive system, 4-day adult     digestive system, 20-day adult     fat body, larvae L3 wandering     fat body, white prepupae     fat body, pupae P8     carcass, larvae L3 wandering     carcass, 1-day adult     carcass, 4-day adult     carcass, 20-day adult     ovary, virgin 4-day female     ovary, mated 4-day female     testis, mated 4-day male     accessory gland, mated 4-day male
modENCODE Development RNA-Seq
modENCODE Temporal Expression Data (modENCODE_mRNA-Seq_U)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of moderate expression. Peak expression observed within 00-18 hour embryonic stages. This gene is annotated by FlyBase as a dicistronic gene, meaning that some or all of its transcripts encode two or more polypeptide-coding open reading frames (ORFs) , with each ORF assigned to a different gene. The distribution of RNA-Seq coverage data amongst the different encoded genes cannot be determined. [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    46 embryo 02-04hr    87 embryo 04-06hr    93 embryo 06-08hr    63 embryo 08-10hr    61 embryo 10-12hr    46 embryo 12-14hr    52 embryo 14-16hr    16 embryo 16-18hr    19 embryo 18-20hr    11 embryo 20-22hr    12 embryo 22-24hr    19 larva L1    17 larva L2    20 larva L3 12hr old    16 larva L3 puffstage 1-2    20 larva L3 puffstage 3-6    26 larva L3 puffstage 7-9    39 white prepupae new    34 white prepupae 12hr    33 white prepupae 24hr    39 pupae 2d postWPP    29 pupae 3d postWPP    17 pupae 4d postWPP    7 adult male 01day    11 adult male 05day    11 adult male 30day    8 adult female 01day    16 adult female 05day    37 adult female 30day    32 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (46) embryo 02-04hr  (87) embryo 04-06hr  (93) embryo 06-08hr  (63) embryo 08-10hr  (61) embryo 10-12hr  (46) embryo 12-14hr  (52) embryo 14-16hr    16 embryo 16-18hr    19 embryo 18-20hr    11 embryo 20-22hr    12 embryo 22-24hr    19 larva L1    17 larva L2    20 larva L3 12hr old    16 larva L3 puffstage 1-2    20 larva L3 puffstage 3-6  26 larva L3 puffstage 7-9  (39) white prepupae new  (34) white prepupae 12hr  (33) white prepupae 24hr  (39) pupae 2d postWPP  (29) pupae 3d postWPP    17 pupae 4d postWPP    7 adult male 01day    11 adult male 05day    11 adult male 30day    8 adult female 01day    16 adult female 05day  (37) adult female 30day  (32) Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    46 embryo 02-04hr    87 embryo 04-06hr    93 embryo 06-08hr    63 embryo 08-10hr    61 embryo 10-12hr    46 embryo 12-14hr    52 embryo 14-16hr    16 embryo 16-18hr    19 embryo 18-20hr    11 embryo 20-22hr    12 embryo 22-24hr    19 larva L1    17 larva L2    20 larva L3 12hr old    16 larva L3 puffstage 1-2    20 larva L3 puffstage 3-6    26 larva L3 puffstage 7-9    39 white prepupae new    34 white prepupae 12hr    33 white prepupae 24hr    39 pupae 2d postWPP    29 pupae 3d postWPP    17 pupae 4d postWPP    7 adult male 01day    11 adult male 05day    11 adult male 30day    8 adult female 01day    16 adult female 05day    37 adult female 30day    32 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    46 embryo 02-04hr    87 embryo 04-06hr    93 embryo 06-08hr    63 embryo 08-10hr    61 embryo 10-12hr    46 embryo 12-14hr    52 embryo 14-16hr    16 embryo 16-18hr    19 embryo 18-20hr    11 embryo 20-22hr    12 embryo 22-24hr    19 larva L1    17 larva L2    20 larva L3 12hr old    16 larva L3 puffstage 1-2    20 larva L3 puffstage 3-6    26 larva L3 puffstage 7-9    39 white prepupae new    34 white prepupae 12hr    33 white prepupae 24hr    39 pupae 2d postWPP    29 pupae 3d postWPP    17 pupae 4d postWPP    7 adult male 01day    11 adult male 05day    11 adult male 30day    8 adult female 01day    16 adult female 05day    37 adult female 30day    32 Expression Level Scale  Extremely high  log, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    46 embryo 02-04hr    87 embryo 04-06hr    93 embryo 06-08hr    63 embryo 08-10hr    61 embryo 10-12hr    46 embryo 12-14hr    52 embryo 14-16hr    16 embryo 16-18hr    19 embryo 18-20hr    11 embryo 20-22hr    12 embryo 22-24hr    19 larva L1    17 larva L2    20 larva L3 12hr old    16 larva L3 puffstage 1-2    20 larva L3 puffstage 3-6    26 larva L3 puffstage 7-9    39 white prepupae new    34 white prepupae 12hr    33 white prepupae 24hr    39 pupae 2d postWPP    29 pupae 3d postWPP    17 pupae 4d postWPP    7 adult male 01day    11 adult male 05day    11 adult male 30day    8 adult female 01day    16 adult female 05day    37 adult female 30day    32 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (46) embryo 02-04hr  (87) embryo 04-06hr  (93) embryo 06-08hr  (63) embryo 08-10hr  (61) embryo 10-12hr  (46) embryo 12-14hr  (52) embryo 14-16hr    16 embryo 16-18hr    19 embryo 18-20hr    11 embryo 20-22hr    12 embryo 22-24hr    19 larva L1    17 larva L2    20 larva L3 12hr old    16 larva L3 puffstage 1-2    20 larva L3 puffstage 3-6  26 larva L3 puffstage 7-9  (39) white prepupae new  (34) white prepupae 12hr  (33) white prepupae 24hr  (39) pupae 2d postWPP  29 pupae 3d postWPP    17 pupae 4d postWPP    7 adult male 01day    11 adult male 05day    11 adult male 30day    8 adult female 01day    16 adult female 05day  (37) adult female 30day  32 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    46 embryo 02-04hr    87 embryo 04-06hr    93 embryo 06-08hr    63 embryo 08-10hr    61 embryo 10-12hr    46 embryo 12-14hr    52 embryo 14-16hr    16 embryo 16-18hr    19 embryo 18-20hr    11 embryo 20-22hr    12 embryo 22-24hr    19 larva L1    17 larva L2    20 larva L3 12hr old    16 larva L3 puffstage 1-2    20 larva L3 puffstage 3-6    26 larva L3 puffstage 7-9    39 white prepupae new    34 white prepupae 12hr    33 white prepupae 24hr    39 pupae 2d postWPP    29 pupae 3d postWPP    17 pupae 4d postWPP    7 adult male 01day    11 adult male 05day    11 adult male 30day    8 adult female 01day    16 adult female 05day    37 adult female 30day    32 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    46 embryo 02-04hr    87 embryo 04-06hr    93 embryo 06-08hr    63 embryo 08-10hr    61 embryo 10-12hr    46 embryo 12-14hr    52 embryo 14-16hr    16 embryo 16-18hr    19 embryo 18-20hr    11 embryo 20-22hr    12 embryo 22-24hr    19 larva L1    17 larva L2    20 larva L3 12hr old    16 larva L3 puffstage 1-2    20 larva L3 puffstage 3-6    26 larva L3 puffstage 7-9    39 white prepupae new    34 white prepupae 12hr    33 white prepupae 24hr    39 pupae 2d postWPP    29 pupae 3d postWPP    17 pupae 4d postWPP    7 adult male 01day    11 adult male 05day    11 adult male 30day    8 adult female 01day    16 adult female 05day    37 adult female 30day    32 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     modENCODE Temporal Expression Data (Graveley et al., 2011)
modENCODE Cell Lines RNA-Seq
modENCODE Cell Line Expression Data (modENCODE_mRNA-Seq_cell.A) (modENCODE_mRNA-Seq_cell.B)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    124 Schneider line 2 Sg4    40 embryonic 1182-4H    24 embryonic GM2    31 embryonic Kc167    61 embryonic S1    63 embryonic S3    68 leg disc CME L1    28 wing disc CME-W2    55 wing disc ML-DmD8    40 wing disc ML-DmD9    51 wing disc ML-DmD16-c3    48 wing disc ML-DmD21    95 wing disc ML-DmD32    28 haltere disc ML-DmD17-c3    84 eye-antennal disc ML-DmD11    34 antennal disc ML-DmD20-c5    42 mixed discs ML-DmD4-c1    31 CNS ML-DmBG1-c1    36 CNS ML-DmBG2-c2    31 tumorous blood cells mbn2    47 ovary fGS/OSS    19 ovary OSC    49 ovary OSS    20 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+  (124) Schneider line 2 Sg4  (40) embryonic 1182-4H    24 embryonic GM2  (31) embryonic Kc167  (61) embryonic S1  (63) embryonic S3  (68) leg disc CME L1  (28) wing disc CME-W2  (55) wing disc ML-DmD8  (40) wing disc ML-DmD9  (51) wing disc ML-DmD16-c3  (48) wing disc ML-DmD21  (95) wing disc ML-DmD32  (28) haltere disc ML-DmD17-c3  (84) eye-antennal disc ML-DmD11  (34) antennal disc ML-DmD20-c5  (42) mixed discs ML-DmD4-c1  (31) CNS ML-DmBG1-c1  (36) CNS ML-DmBG2-c2  (31) tumorous blood cells mbn2  (47) ovary fGS/OSS    19 ovary OSC  (49) ovary OSS    20 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+  (124) Schneider line 2 Sg4    40 embryonic 1182-4H    24 embryonic GM2    31 embryonic Kc167    61 embryonic S1    63 embryonic S3    68 leg disc CME L1    28 wing disc CME-W2    55 wing disc ML-DmD8    40 wing disc ML-DmD9    51 wing disc ML-DmD16-c3    48 wing disc ML-DmD21    95 wing disc ML-DmD32    28 haltere disc ML-DmD17-c3    84 eye-antennal disc ML-DmD11    34 antennal disc ML-DmD20-c5    42 mixed discs ML-DmD4-c1    31 CNS ML-DmBG1-c1    36 CNS ML-DmBG2-c2    31 tumorous blood cells mbn2    47 ovary fGS/OSS    19 ovary OSC    49 ovary OSS    20 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    124 Schneider line 2 Sg4    40 embryonic 1182-4H    24 embryonic GM2    31 embryonic Kc167    61 embryonic S1    63 embryonic S3    68 leg disc CME L1    28 wing disc CME-W2    55 wing disc ML-DmD8    40 wing disc ML-DmD9    51 wing disc ML-DmD16-c3    48 wing disc ML-DmD21    95 wing disc ML-DmD32    28 haltere disc ML-DmD17-c3    84 eye-antennal disc ML-DmD11    34 antennal disc ML-DmD20-c5    42 mixed discs ML-DmD4-c1    31 CNS ML-DmBG1-c1    36 CNS ML-DmBG2-c2    31 tumorous blood cells mbn2    47 ovary fGS/OSS    19 ovary OSC    49 ovary OSS    20 Expression Level Scale  Extremely high  log, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    124 Schneider line 2 Sg4    40 embryonic 1182-4H    24 embryonic GM2    31 embryonic Kc167    61 embryonic S1    63 embryonic S3    68 leg disc CME L1    28 wing disc CME-W2    55 wing disc ML-DmD8    40 wing disc ML-DmD9    51 wing disc ML-DmD16-c3    48 wing disc ML-DmD21    95 wing disc ML-DmD32    28 haltere disc ML-DmD17-c3    84 eye-antennal disc ML-DmD11    34 antennal disc ML-DmD20-c5    42 mixed discs ML-DmD4-c1    31 CNS ML-DmBG1-c1    36 CNS ML-DmBG2-c2    31 tumorous blood cells mbn2    47 ovary fGS/OSS    19 ovary OSC    49 ovary OSS    20 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+  (124) Schneider line 2 Sg4  (40) embryonic 1182-4H    24 embryonic GM2  31 embryonic Kc167  (61) embryonic S1  (63) embryonic S3  (68) leg disc CME L1  28 wing disc CME-W2  (55) wing disc ML-DmD8  (40) wing disc ML-DmD9  (51) wing disc ML-DmD16-c3  (48) wing disc ML-DmD21  (95) wing disc ML-DmD32  28 haltere disc ML-DmD17-c3  (84) eye-antennal disc ML-DmD11  (34) antennal disc ML-DmD20-c5  (42) mixed discs ML-DmD4-c1  31 CNS ML-DmBG1-c1  (36) CNS ML-DmBG2-c2  31 tumorous blood cells mbn2  (47) ovary fGS/OSS    19 ovary OSC  (49) ovary OSS    20 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+  124 Schneider line 2 Sg4    40 embryonic 1182-4H    24 embryonic GM2    31 embryonic Kc167    61 embryonic S1    63 embryonic S3    68 leg disc CME L1    28 wing disc CME-W2    55 wing disc ML-DmD8    40 wing disc ML-DmD9    51 wing disc ML-DmD16-c3    48 wing disc ML-DmD21    95 wing disc ML-DmD32    28 haltere disc ML-DmD17-c3    84 eye-antennal disc ML-DmD11    34 antennal disc ML-DmD20-c5    42 mixed discs ML-DmD4-c1    31 CNS ML-DmBG1-c1    36 CNS ML-DmBG2-c2    31 tumorous blood cells mbn2    47 ovary fGS/OSS    19 ovary OSC    49 ovary OSS    20 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    124 Schneider line 2 Sg4    40 embryonic 1182-4H    24 embryonic GM2    31 embryonic Kc167    61 embryonic S1    63 embryonic S3    68 leg disc CME L1    28 wing disc CME-W2    55 wing disc ML-DmD8    40 wing disc ML-DmD9    51 wing disc ML-DmD16-c3    48 wing disc ML-DmD21    95 wing disc ML-DmD32    28 haltere disc ML-DmD17-c3    84 eye-antennal disc ML-DmD11    34 antennal disc ML-DmD20-c5    42 mixed discs ML-DmD4-c1    31 CNS ML-DmBG1-c1    36 CNS ML-DmBG2-c2    31 tumorous blood cells mbn2    47 ovary fGS/OSS    19 ovary OSC    49 ovary OSS    20 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Cell Line   Expression Level Schneider line 2 S2R+     Schneider line 2 Sg4     embryonic 1182-4H     embryonic GM2     embryonic Kc167     embryonic S1     embryonic S3     leg disc CME L1     wing disc CME-W2     wing disc ML-DmD8     wing disc ML-DmD9     wing disc ML-DmD16-c3     wing disc ML-DmD21     wing disc ML-DmD32     haltere disc ML-DmD17-c3     eye-antennal disc ML-DmD11     antennal disc ML-DmD20-c5     mixed discs ML-DmD4-c1     CNS ML-DmBG1-c1     CNS ML-DmBG2-c2     tumorous blood cells mbn2     ovary fGS/OSS     ovary OSC     ovary OSS
modENCODE Treatments RNA-Seq
modENCODE Treatment Expression Data (modENCODE_mRNA-Seq_treatments)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    13 cold shock, 4-day adult    10 heat shock, 4-day adult    20 Cadmium 50 mM 6 hrs, larvae L3    19 Cadmium 50 mM 12 hrs, larvae L3    40 Cadmium 50 mM 48 hrs, 4-day adult    22 Cadmium 100 mM 48 hrs, 4-day adult    29 Copper 0.5 mM 12 hrs, larvae L3    12 Copper 15 mM 48 hrs, 4-day adult    19 Zinc 5 mM 12 hrs, larvae L3    13 Zinc 4.5 mM 48 hrs, 4-day adult    15 Ethanol 2.5% 3 hrs, larvae L3    26 Ethanol 5% 3 hrs, larvae L3    26 Ethanol 10% 3 hrs, larvae L3    16 Caffeine 1.5 mg/ml 4 hrs, larvae L3    22 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    20 Caffeine 25 mg/ml 48 hrs, 4-day adult    7 Paraquat 5 mM 48 hrs, 4-day adult    23 Paraquat 10 mM 48 hrs, 4-day adult    20 Rotenone 2 μg 12 hrs, larvae L3    27 Rotenone 8 μg 12 hrs, larvae L3    15 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult    13 cold shock, 4-day adult    10 heat shock, 4-day adult    20 Cadmium 50 mM 6 hrs, larvae L3    19 Cadmium 50 mM 12 hrs, larvae L3  (40) Cadmium 50 mM 48 hrs, 4-day adult    22 Cadmium 100 mM 48 hrs, 4-day adult  (29) Copper 0.5 mM 12 hrs, larvae L3    12 Copper 15 mM 48 hrs, 4-day adult    19 Zinc 5 mM 12 hrs, larvae L3    13 Zinc 4.5 mM 48 hrs, 4-day adult    15 Ethanol 2.5% 3 hrs, larvae L3  26 Ethanol 5% 3 hrs, larvae L3  26 Ethanol 10% 3 hrs, larvae L3    16 Caffeine 1.5 mg/ml 4 hrs, larvae L3    22 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    20 Caffeine 25 mg/ml 48 hrs, 4-day adult    7 Paraquat 5 mM 48 hrs, 4-day adult    23 Paraquat 10 mM 48 hrs, 4-day adult    20 Rotenone 2 μg 12 hrs, larvae L3  (27) Rotenone 8 μg 12 hrs, larvae L3    15 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    13 cold shock, 4-day adult    10 heat shock, 4-day adult    20 Cadmium 50 mM 6 hrs, larvae L3    19 Cadmium 50 mM 12 hrs, larvae L3    40 Cadmium 50 mM 48 hrs, 4-day adult    22 Cadmium 100 mM 48 hrs, 4-day adult    29 Copper 0.5 mM 12 hrs, larvae L3    12 Copper 15 mM 48 hrs, 4-day adult    19 Zinc 5 mM 12 hrs, larvae L3    13 Zinc 4.5 mM 48 hrs, 4-day adult    15 Ethanol 2.5% 3 hrs, larvae L3    26 Ethanol 5% 3 hrs, larvae L3    26 Ethanol 10% 3 hrs, larvae L3    16 Caffeine 1.5 mg/ml 4 hrs, larvae L3    22 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    20 Caffeine 25 mg/ml 48 hrs, 4-day adult    7 Paraquat 5 mM 48 hrs, 4-day adult    23 Paraquat 10 mM 48 hrs, 4-day adult    20 Rotenone 2 μg 12 hrs, larvae L3    27 Rotenone 8 μg 12 hrs, larvae L3    15 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    13 cold shock, 4-day adult    10 heat shock, 4-day adult    20 Cadmium 50 mM 6 hrs, larvae L3    19 Cadmium 50 mM 12 hrs, larvae L3    40 Cadmium 50 mM 48 hrs, 4-day adult    22 Cadmium 100 mM 48 hrs, 4-day adult    29 Copper 0.5 mM 12 hrs, larvae L3    12 Copper 15 mM 48 hrs, 4-day adult    19 Zinc 5 mM 12 hrs, larvae L3    13 Zinc 4.5 mM 48 hrs, 4-day adult    15 Ethanol 2.5% 3 hrs, larvae L3    26 Ethanol 5% 3 hrs, larvae L3    26 Ethanol 10% 3 hrs, larvae L3    16 Caffeine 1.5 mg/ml 4 hrs, larvae L3    22 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    20 Caffeine 25 mg/ml 48 hrs, 4-day adult    7 Paraquat 5 mM 48 hrs, 4-day adult    23 Paraquat 10 mM 48 hrs, 4-day adult    20 Rotenone 2 μg 12 hrs, larvae L3    27 Rotenone 8 μg 12 hrs, larvae L3    15 Expression Level Scale  Extremely high  log, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    13 cold shock, 4-day adult    10 heat shock, 4-day adult    20 Cadmium 50 mM 6 hrs, larvae L3    19 Cadmium 50 mM 12 hrs, larvae L3    40 Cadmium 50 mM 48 hrs, 4-day adult    22 Cadmium 100 mM 48 hrs, 4-day adult    29 Copper 0.5 mM 12 hrs, larvae L3    12 Copper 15 mM 48 hrs, 4-day adult    19 Zinc 5 mM 12 hrs, larvae L3    13 Zinc 4.5 mM 48 hrs, 4-day adult    15 Ethanol 2.5% 3 hrs, larvae L3    26 Ethanol 5% 3 hrs, larvae L3    26 Ethanol 10% 3 hrs, larvae L3    16 Caffeine 1.5 mg/ml 4 hrs, larvae L3    22 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    20 Caffeine 25 mg/ml 48 hrs, 4-day adult    7 Paraquat 5 mM 48 hrs, 4-day adult    23 Paraquat 10 mM 48 hrs, 4-day adult    20 Rotenone 2 μg 12 hrs, larvae L3    27 Rotenone 8 μg 12 hrs, larvae L3    15 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  log, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult    13 cold shock, 4-day adult    10 heat shock, 4-day adult    20 Cadmium 50 mM 6 hrs, larvae L3    19 Cadmium 50 mM 12 hrs, larvae L3  (40) Cadmium 50 mM 48 hrs, 4-day adult    22 Cadmium 100 mM 48 hrs, 4-day adult  29 Copper 0.5 mM 12 hrs, larvae L3    12 Copper 15 mM 48 hrs, 4-day adult    19 Zinc 5 mM 12 hrs, larvae L3    13 Zinc 4.5 mM 48 hrs, 4-day adult    15 Ethanol 2.5% 3 hrs, larvae L3  26 Ethanol 5% 3 hrs, larvae L3  26 Ethanol 10% 3 hrs, larvae L3    16 Caffeine 1.5 mg/ml 4 hrs, larvae L3    22 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    20 Caffeine 25 mg/ml 48 hrs, 4-day adult    7 Paraquat 5 mM 48 hrs, 4-day adult    23 Paraquat 10 mM 48 hrs, 4-day adult    20 Rotenone 2 μg 12 hrs, larvae L3  27 Rotenone 8 μg 12 hrs, larvae L3    15 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    13 cold shock, 4-day adult    10 heat shock, 4-day adult    20 Cadmium 50 mM 6 hrs, larvae L3    19 Cadmium 50 mM 12 hrs, larvae L3    40 Cadmium 50 mM 48 hrs, 4-day adult    22 Cadmium 100 mM 48 hrs, 4-day adult    29 Copper 0.5 mM 12 hrs, larvae L3    12 Copper 15 mM 48 hrs, 4-day adult    19 Zinc 5 mM 12 hrs, larvae L3    13 Zinc 4.5 mM 48 hrs, 4-day adult    15 Ethanol 2.5% 3 hrs, larvae L3    26 Ethanol 5% 3 hrs, larvae L3    26 Ethanol 10% 3 hrs, larvae L3    16 Caffeine 1.5 mg/ml 4 hrs, larvae L3    22 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    20 Caffeine 25 mg/ml 48 hrs, 4-day adult    7 Paraquat 5 mM 48 hrs, 4-day adult    23 Paraquat 10 mM 48 hrs, 4-day adult    20 Rotenone 2 μg 12 hrs, larvae L3    27 Rotenone 8 μg 12 hrs, larvae L3    15 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    13 cold shock, 4-day adult    10 heat shock, 4-day adult    20 Cadmium 50 mM 6 hrs, larvae L3    19 Cadmium 50 mM 12 hrs, larvae L3    40 Cadmium 50 mM 48 hrs, 4-day adult    22 Cadmium 100 mM 48 hrs, 4-day adult    29 Copper 0.5 mM 12 hrs, larvae L3    12 Copper 15 mM 48 hrs, 4-day adult    19 Zinc 5 mM 12 hrs, larvae L3    13 Zinc 4.5 mM 48 hrs, 4-day adult    15 Ethanol 2.5% 3 hrs, larvae L3    26 Ethanol 5% 3 hrs, larvae L3    26 Ethanol 10% 3 hrs, larvae L3    16 Caffeine 1.5 mg/ml 4 hrs, larvae L3    22 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    20 Caffeine 25 mg/ml 48 hrs, 4-day adult    7 Paraquat 5 mM 48 hrs, 4-day adult    23 Paraquat 10 mM 48 hrs, 4-day adult    20 Rotenone 2 μg 12 hrs, larvae L3    27 Rotenone 8 μg 12 hrs, larvae L3    15 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Treatment   Expression Level extended cold, 4-day adult     cold shock, 4-day adult     heat shock, 4-day adult     Cadmium 50 mM 6 hrs, larvae L3     Cadmium 50 mM 12 hrs, larvae L3     Cadmium 50 mM 48 hrs, 4-day adult     Cadmium 100 mM 48 hrs, 4-day adult     Copper 0.5 mM 12 hrs, larvae L3     Copper 15 mM 48 hrs, 4-day adult     Zinc 5 mM 12 hrs, larvae L3     Zinc 4.5 mM 48 hrs, 4-day adult     Ethanol 2.5% 3 hrs, larvae L3     Ethanol 5% 3 hrs, larvae L3     Ethanol 10% 3 hrs, larvae L3     Caffeine 1.5 mg/ml 4 hrs, larvae L3     Caffeine 2.5 mg/ml 48 hrs, 4-day adult     Caffeine 25 mg/ml 48 hrs, 4-day adult     Paraquat 5 mM 48 hrs, 4-day adult     Paraquat 10 mM 48 hrs, 4-day adult     Rotenone 2 μg 12 hrs, larvae L3     Rotenone 8 μg 12 hrs, larvae L3
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (Graveley et al., 2011) mE1_20_mRNA_expression_cluster_04
External Data & Images
Linkouts	BDGP expression data • SD12355 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0261437
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele lethal | prepupal stage (with CSN850-2) CSN8SH1829 lethal | prepupal stage (with CSN8SH1829) CSN850-2 lethal | recessive CSN8SH1829 lethal | recessive | third instar larval stage CSN850-2 lethal | third instar larval stage (with CSN850-2) CSN8SH1829 lethal | third instar larval stage (with CSN8SH1829) CSN850-2 Other Phenotypes Allele developmental rate defective | third instar larval stage (with CSN850-2) CSN8SH1829 developmental rate defective | third instar larval stage (with CSN8SH1829) CSN850-2 immune response defective | third instar larval stage (with CSN850-2) CSN8SH1829 immune response defective | third instar larval stage (with CSN8SH1829) CSN850-2 melanotic mass phenotype | recessive | third instar larval stage CSN850-2 small body | recessive | third instar larval stage CSN850-2 visible | somatic clone CSN850-2 CSN8unspecified Phenotype manifest in Allele chaeta & mesothoracic tergum | somatic clone CSN8unspecified eye | somatic clone CSN850-2 melanotic mass | third instar larval stage CSN850-2 mesothoracic tergum | somatic clone CSN8unspecified ovary | germline clone CSN850-2 posterior crossvein | somatic clone CSN8unspecified scutellum | somatic clone CSN8unspecified wing | somatic clone CSN8unspecified wing vein | ectopic | somatic clone CSN8unspecified
Classical Alleles ( 4 )
For All Classical Alleles Show
Allele of CSN8 Class Mutagen Stocks Known lesion CSN840-1 P-element activity 0 Yes CSN850-2 P-element activity 0 Yes CSN8SH1829 P-element activity 0 Yes CSN8unspecified 0 --
Alleles Carried on Transgenic Constructs ( 3 )
For All Alleles Carried on Transgenic Constructs Show
Allele of CSN8 Class Mutagen Stocks Known lesion CSN8HMS00243 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes CSN8dsRNA.cRa in vitro construct - RNAi 0 Yes CSN8NIG.13383R in vitro construct - RNAi in vitro construct - regulatory fusion 0 Yes
Aneuploid Aberrations
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD17585} NA P{NIG.13383R} NA P{TRiP.HMS00243} NA
Insertions
	Type of insertions Name Expression data insertion of enhancer trap P{lacW}CSN8SH1829 No miscellaneous insertions P{?EPgy2}CSN840-1 NA P{?EPgy2}CSN850-2 NA
Gene Ontology: Function, Process & Cellular Component ( 8 unique terms )
Terms Based on Experimental Evidence ( 7 terms )
Molecular Function ( 0 terms)
Biological Process
CV term Evidence References
compound eye morphogenesis inferred from mutant phenotype (Oren-Giladi et al., 2008) defense response to bacterium inferred from mutant phenotype (Oren-Giladi et al., 2008) imaginal disc-derived wing morphogenesis inferred from mutant phenotype (Oren-Giladi et al., 2008) mitotic G2 DNA damage checkpoint inferred from genetic interaction with nbs (Kondo and Perrimon, 2011) oogenesis inferred from mutant phenotype (Oren-Giladi et al., 2008) protein stabilization inferred from mutant phenotype (Ullah et al., 2007) regulation of cell cycle inferred from direct assay (Guest et al., 2011)
Cellular Component ( 0 terms)
Terms Based on Predictions or Assertions ( 1 term )
Molecular Function ( 0 terms)
Biological Process ( 0 terms)
Cellular Component
CV term Evidence References
signalosome inferred from sequence or structural similarity with TAIR:COP9:1944512 (Freilich et al., 1999) inferred from sequence or structural similarity with UniProtKB:Q8VBV7 (FlyBase Genome Annotators, 2004)
Sequence Ontology: Class of Gene
	gene   nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
protein-protein
Interacting group Assay References
CSN8 - CSN4 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23)
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions CSN8 allele Gene References
External Data
Linkouts	DroID - A comprehensive database of gene and protein interactions. • FBgn0261437 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 49077
Orthologs
OrthoDB Orthologs (38) - based on analysis using Dmel annotation version 5.41
OrthoDB Ortholog Groups
	OrthoDB orthology group searches (Waterhouse et al., 2011, Nucleic Acids Res. 39(Database issue): D283--D288) Drosophila inclusive ortholog search EOG63FHHJ Dipteran inclusive ortholog search EOG6HT92M Insect inclusive ortholog search EOG6WDC8F Arthropod inclusive ortholog search EOG6GXD4D Metazoa inclusive ortholog search EOG65BD9R
Orthologs in Drosophila Species (EOG63FHHJ)
Organism Common Name Gene AAA Syntenic Ortholog Multiple Dmel Genes in this Orthologous Group Drosophila melanogaster fruit fly  Dmel\CSN8     Drosophila simulans   Dsim\GD23529 Y   Drosophila sechellia   Dsec\GM16907 Y   Drosophila erecta   Dere\GG10539 Y   Drosophila yakuba   Dyak\GE18760 Y   Drosophila ananassae   Dana\GF15220 Y   Drosophila pseudoobscura pseudoobscura   Dpse\GA25879 Y   Drosophila persimilis   Dper\GL19225 Y   Drosophila willistoni   Dwil\GK24158 Y   Drosophila virilis   Dvir\GJ16140 Y   Drosophila mojavensis   Dmoj\GI17351 Y   Drosophila grimshawi   Dgri\GH10836 Y
Orthologs in non-Drosophila Dipterans (EOG6HT92M)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Aedes aegypti Yellow fever mosquito  Aaeg\AAEL007821   Anopheles gambiae Malaria mosquito  Agam\AGAP008857   Culex quinquefasciatus Southern house mosquito  Cqui\CPIJ005261
Orthologs in non-Dipteran Insects (EOG6WDC8F)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Apis mellifera Western honey bee  Amel\LOC408424   Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG008485   Acromyrmex echinatior Panamanian leafcutter ant  Aech\AECH13406   Atta cephalotes Leafcutter ant  Acep\ACEP24787   Camponotus floridanus Florida carpenter ant  Cflo\CFLO16450   Harpegnathos saltator Jerdons jumping ant  Hsal\HSAL18088   Linepithema humile Argentine ant  Lhum\LH22038   Pogonomyrmex barbatus Red harvester ant  Pbar\PB13201   Solenopsis invicta Red fire ant  Sinv\SINV24889   Acyrthosiphon pisum Pea aphid  Apim\ACYPI008445   Bombyx mori Silkmoth  Bmor\BGIBMGA003205   Pediculus humanus Human body louse  Phum\PHUM074550   Tribolium castaneum Red flour beetle  Tcas\TC030655
Orthologs in non-Insect Arthropods (EOG6GXD4D)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Daphnia pulex Water flea  Dpux\JGI_V11_306778   Ixodes scapularis Deer tick  Isca\ISCW013975
Orthologs in non-Arthropod Metazoa (EOG65BD9R)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_023079gn   Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_014232gn   Danio rerio Zebrafish  Drer\cops8   Xenopus tropicalis Western clawed frog  Xtro\ENSXETG00000025427   Gallus gallus Domestic chicken  Ggal\COPS8   Mus musculus House mouse  Mmus\Cops8   Rattus norvegicus Norway rat  Rnor\Cops8   Homo sapiens Human  Hsap\COP9
Human Orthologs (1)
Gene OMIM HGNC Hsap\COP9
AAA Orthologs (11) based on analysis using Dmel annotation version 4.3
Organism Gene Drosophila simulans Dsim\GD23529 Drosophila sechellia Dsec\GM16907 Drosophila erecta Dere\GG10539 Drosophila yakuba Dyak\GE18760 Drosophila ananassae Dana\GF15220 Drosophila pseudoobscura pseudoobscura Dpse\GA25879 Drosophila persimilis Dper\GL19225 Drosophila willistoni Dwil\GK24158 Drosophila virilis Dvir\GJ16140 Drosophila mojavensis Dmoj\GI17351 Drosophila grimshawi Dgri\GH10836
Stocks & Reagents
Stocks Listed in FlyBase ( 1 )
Bloomington	33370 y1 sc* v1; P{TRiP.HMS00243}attP2/TM3, Sb1
Genomic Clones ( 1 )
	BACR15P08 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 5 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	LD10247 SD12355
Other clones
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones
Other clones	Dmel_dig_012005_0692_2678 Dmel_neb_014568_0878_2584 FGM208H08
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0261437 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 49077
Antibody Information
	polyclonal (Oren-Giladi et al., 2008)
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of
Source for database merge of	Source for merge of: CSN8 l(2)SH1829 (Oren-Giladi et al., 2008)
Additional comments	The symbol "CG13383" has been used erroneously in FlyBase to name 2 adjacent annotations in different releases of the genome annotation. The two annotations represent the CSN8 and Pp2A-29B genes. In release 2 of the genome annotation, the "CG13383" annotation corresponded to the CSN8 open reading frame (ORF), and the annotation corresponding to Pp2A-29B was labelled "CG17291". In release 3.1 of the genome annotation, the "CG13383" annotation corresponded to the Pp2A-29B open reading frame (ORF). In release 3.2 of the genome annotation, the two genes were annotated as part of a dicistronic transcript represented by the "CG33297" annotation. In release 5.1 of the genome annotation, the two genes were annotated as monocistronic transcripts, as there was no longer sufficient evidence to support a processed dicistronic transcript, with the annotation representing the Pp2A-29B gene being labelled "CG17291" and the annotation representing the CSN8 gene being labelled "CG13383". Since the "CG13383" symbol has been used for two different annotations, the annotation for the CSN8 gene has been renamed to "CG42522" in release 5.13 of the genome annotation to avoid confusion. (FlyBase Genome Annotators, 2008) RT-PCR analysis of CSN8 and Pp2A-29B transcription provides no evidence that a dicistronic transcript containing both open reading frames is produced. Thus it is concluded that CSN8 is transcribed independently of Pp2A-29B and that a dicistronic transcript is unlikely or is present at undetectable levels. (Oren-Giladi et al., 2008) CSN8 and Pp2A-29B were annotated as being non-overlapping open reading frames derived from a processed dicistronic transcript in release 3.2 of the genome based on the LD10247 cDNA. However, this clone appears to be problematic and there is no longer sufficient evidence to support a processed dicistronic transcript, thus CSN8 and Pp2A-29B have been annotated as genes encoded by monocistronic transcripts in release 5.1 of the genome annotation. (FlyBase Genome Annotators, 2006)
Other Comments
	3 alleles of l(2)SH1829 recovered in a P-insertion screen. (Oh et al., 2003) Identification: On the basis of sequence similarity to COP9 signalosome units. (Freilich et al., 1999) No distinct cDNA has been detected for CSN8, but a sequence putatively encoding CSN8 is found in the 5' untranslated region of the Pp2A-29B gene. (Freilich et al., 1999) COP9 signalosome is essential for development. (Freilich et al., 1999)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_164809 RefSeq (Proteins) • NP_723378 DDBJ / EMBL / GenBank • AA391357 AAF52650.2 AAF52651.1 AAN10662 AAN10662.1 AAS64736.1 AB082663 AW942119 Entrez Gene - A searchable database of RefSeq genes. • 49077 UniProtKB/Swiss-Prot • Q7KTH8
Other Crossreferences
	BDGP expression data - Patterns of gene expression in Drosophila embryogenesis • SD12355
Linkouts
	DroID - A comprehensive database of gene and protein interactions. • FBgn0261437 DRSC - Results from RNAi screens. • FBgn0261437 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0261437 FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0261437 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 49077 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 49077 modMine - Data generated by the modENCODE project. • FBgn0261437
Synonyms & Secondary IDs ( 14 )
Reported As
Symbol Synonym	CG13383 (FlyBase Genome Annotators, 2008, Ramet et al., 2002, Robertson, 2001.5.6, Giot et al., 2003, Rogers et al., 2003, Cammarato et al., 2011) CG33297   CG42522 (FlyBase Genome Annotators, 2008, Ni et al., 2010.12.1) CH8   Csn8 (Oron et al., 2007, Ullah et al., 2007) CSN8 (Segal et al., 2007, Buckley et al., 2007, Buckley et al., 2006, Oren-Giladi et al., 2008, Mummery-Widmer et al., 2009, Kondo and Perrimon, 2011, Guruharsha et al., 2011, Guest et al., 2011, Japanese National Institute of Genetics, 2012.5.21) csn8 (Segal et al., 2007, Oren-Giladi et al., 2008, Ullah et al., 2007) Dch8 (Freilich et al., 1999) l(2)SH2 1829 (Oh et al., 2002.3.26) l(2)SH1829
Name Synonym	COP9 complex homolog subunit 8   Cop9 signalosome subunit 8 (Oren-Giladi et al., 2008) CSN8 (Cammarato et al., 2011) Drosophila COP9 signalosome homolog 8 (Freilich et al., 1999) lethal (2) SH1829
Secondary FlyBase IDs
	FBgn0005776 FBgn0028835 FBgn0032027 FBgn0053297 FBgn0065343
References ( 33 )
Generate a list of	All references relating to this gene ( 33 )
List References by type	Research paper  ( 9 ) Supplementary material  ( 6 ) Review  ( 2 ) Personal communication to FlyBase  ( 4 ) Abstract  ( 3 ) FlyBase analysis  ( 6 ) DNA/RNA sequence record  ( 1 ) Stock list  ( 1 ) Website  ( 1 )
Recent research papers ( 3 )
	Guest et al., 2011, BMC Syst. Biol. 5(1): 65 A protein network-guided screen for cell cycle regulators in Drosophila. [FBrf0213913] Guruharsha et al., 2011, Cell 147(3): 690--703 A Protein Complex Network of Drosophila melanogaster. [FBrf0216491] Kondo and Perrimon, 2011, Sci. Signal. 4(154): rs1 A Genome-Wide RNAi Screen Identifies Core Components of the G2-M DNA Damage Checkpoint. [FBrf0212700] Show all research papers ...
Recent reviews (0)
	All reviews listed in FlyBase were published before 2011 Show reviews ...