FlyBase Gene Report: Dmel\SdhA

General Information

Symbol

Dmel\SdhA

Species

D. melanogaster

Name

Succinate dehydrogenase, subunit A (flavoprotein)

Annotation Symbol

CG17246

Feature Type

protein_coding_gene

FlyBase ID

FBgn0261439

Gene Model Status

Current

Stock Availability

12 publicly available

Gene Snapshot

Succinate dehydrogenase, subunit A (flavoprotein) (SdhA) encodes the FAD-containing subunit of the succinate dehydrogenase complex. It directly oxidizes succinate to fumarate and transfers the electrons to other subunits and eventually to quinones. [Date last reviewed: 2019-09-26]

Other Summaries

Alliance
Auto summary
Gene Group
UniProtKB
Red Book
Interactive Fly

Also Known As

Scs-fp, succinate dehydrogenase, Succinyl coenzyme A synthetase flavoprotein subunit, Succinate dehydrogenase A, sdh

Key Links

Genomic Location

Cytogenetic map

56D3-56D3

Sequence location

2R:19,391,863..19,395,971 [-]

Recombination map

2-89

RefSeq locus

NT_033778 REGION:19391863..19395971

Sequence

Get Decorated FASTA

Genomic Maps

JBrowse GBrowse

Help me choose

Other Genome Views

The following external sites may use different assemblies or annotations than FlyBase.

Function

GO Summary Ribbons

Gene Ontology (GO) Annotations (12 terms)

Molecular Function (4 terms)

Terms Based on Experimental Evidence (0 terms)

Terms Based on Predictions or Assertions (4 terms)

CV Term

Evidence

References

enables electron transfer activity

inferred from biological aspect of ancestor with PANTHER:PTN000180228

(assigned by GO_Central )

(Gaudet et al., 2011)

enables flavin adenine dinucleotide binding

inferred from biological aspect of ancestor with PANTHER:PTN000180228

(assigned by GO_Central )

(Gaudet et al., 2011)

enables succinate dehydrogenase (ubiquinone) activity

inferred from biological aspect of ancestor with PANTHER:PTN000180258

(assigned by GO_Central )

(Gaudet et al., 2011)

inferred from sequence or structural similarity with UniProtKB:P31040

(FlyBase Curators, 2008--)

enables succinate dehydrogenase activity

inferred from biological aspect of ancestor with PANTHER:PTN000180228

(assigned by GO_Central )

(Gaudet et al., 2011)

Biological Process (6 terms)

Terms Based on Experimental Evidence (1 term)

CV Term

Evidence

References

involved_in electron transport chain

inferred from mutant phenotype

(assigned by UniProt )

(Mast et al., 2008)

Terms Based on Predictions or Assertions (5 terms)

CV Term

Evidence

References

involved_in mitochondrial electron transport, succinate to ubiquinone

inferred from biological aspect of ancestor with PANTHER:PTN000180258

(assigned by GO_Central )

(Gaudet et al., 2011)

involved_in oxidation-reduction process

inferred from electronic annotation with InterPro:IPR003952, InterPro:IPR011281, InterPro:IPR014006, InterPro:IPR015939, InterPro:IPR037099

(assigned by InterPro )

(FlyBase Curators et al., 2004-)

involved_in respiratory electron transport chain

inferred from sequence or structural similarity with UniProtKB:P31040

(FlyBase Curators, 2008--)

involved_in succinate metabolic process

inferred from sequence or structural similarity with UniProtKB:P31040

(FlyBase Curators, 2008--)

involved_in tricarboxylic acid cycle

inferred from electronic annotation with InterPro:IPR011281

(assigned by InterPro )

(FlyBase Curators et al., 2004-)

Cellular Component (2 terms)

Terms Based on Experimental Evidence (1 term)

CV Term

Evidence

References

located_in mitochondrion

inferred from high throughput direct assay

(Alonso et al., 2005)

Terms Based on Predictions or Assertions (1 term)

CV Term

Evidence

References

part_of mitochondrial respiratory chain complex II, succinate dehydrogenase complex (ubiquinone)

inferred from biological aspect of ancestor with PANTHER:PTN000180258

(assigned by GO_Central )

(Gaudet et al., 2011)

Gene Group (FlyBase)

MITOCHONDRIAL COMPLEX II - SUCCINATE DEHYDROGENASE SUBUNITS

SUCCINATE DEHYDROGENASES

Protein Family (UniProt)

Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily. (Q94523)

Protein Signatures (InterPro)

Summaries

Gene Group (FlyBase)

MITOCHONDRIAL COMPLEX II - SUCCINATE DEHYDROGENASE SUBUNITS -: The succinate dehydrogenase complex (Mitochondrial Complex II) oxidizes succinate to fumarate during the Krebs cycle and reduces ubiquinone in the electron transport chain. (Adapted from PMID:22689576).
SUCCINATE DEHYDROGENASES -: Succinate dehydrogenases (Complex II) during the electron transport chain donate electrons from FADH2 to reduce ubiquinone to ubiquinol, and in the Krebs cycle metabolize succinate to fumarate. (Adapted from PMID:22689576).

Protein Function (UniProtKB)

Flavoprotein (FP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q). Maintaining electron transport chain function is required to prevent neurodegenerative changes seen in both early- and late-onset disorders.

(UniProt, Q94523)

Phenotypic Description (Red Book; Lindsley and Zimm 1992)

Sdh: Succinic dehydrogenase

The structural gene for succinic dehydrogenase (EC 1.3.99.1). Null mutations are homozygous lethal and lethal in heteroallelic combinations; however clones of homozygous cells survive and develop normally. Detected in clones by a cytochemical test for enzyme activity; cell autonomous with low perdurance; an excellent cell marker.

Gene Model and Products

Number of Transcripts

Number of Unique Polypeptides

Please see the JBrowse view of Dmel\SdhA for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)

Isoform displayed:

Pfam protein domains

InterPro name

classification

start

end

Protein Domains (via SMART)

Isoform displayed:

SMART protein domains

InterPro name

classification

start

end

Comments on Gene Model

Low-frequency RNA-Seq exon junction(s) not annotated.

Gene model reviewed during 5.51

Sequence Ontology: Class of Gene

gene

nuclear_gene

protein_coding_gene

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Assoc. CDS (aa)

SdhA-RA

FBtr0086553

NM_057862

2750

661

SdhA-RB

FBtr0086552

NM_166343

2617

661

SdhA-RC

FBtr0086554

NM_166344

2663

661

Additional Transcript Data and Comments

Reported size (kB)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kDa)

Length (aa)

Theoretical pI

RefSeq ID

GenBank

SdhA-PA

FBpp0085737

72.3

661

7.12

NP_477210

AAG22257

SdhA-PB

FBpp0085736

72.3

661

7.12

NP_725881

AAM70849

SdhA-PC

FBpp0085738

72.3

661

7.12

NP_725882

AAN16127

Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

661 aa isoforms: SdhA-PA, SdhA-PB, SdhA-PC

Additional Polypeptide Data and Comments

Reported size (kDa)

Comments

External Data

Subunit Structure (UniProtKB)

Component of complex II composed of four subunits: a flavoprotein (FP), an iron-sulfur protein (IP), and a cytochrome b composed of a large and a small subunit.

(UniProt, Q94523)

Crossreferences

InterPro - A database of protein families, domains and functional sites

Linkouts

Sequences Consistent with the Gene Model

Nucleotide / Polypeptide Records

UniProt

Q94523

Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\SdhA using the Feature Mapper tool.

External Data

Crossreferences

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

SdhA_1

Linkouts

Expression Data

Expression Summary Ribbons

Colored tiles in ribbon indicate that expression data has been curated by FlyBase for that anatomical location. Colorless tiles indicate that there is no curated data for that location.

For complete stage-specific expression data, view the modENCODE Development RNA-Seq section under High-Throughput Expression below.

Transcript Expression

in situ

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage 1 -- 3

organism

Comment: maternally deposited

(Fisher et al., 2012)

embryonic stage 4 -- 6

organism | ubiquitous

(Fisher et al., 2012)

embryonic stage 7 -- 8

organism | faint | ubiquitous

(Fisher et al., 2012)

embryonic stage 9 -- 10

organism | faint | ubiquitous

(Fisher et al., 2012)

embryonic stage 11 -- 12

anterior midgut primordium

(Fisher et al., 2012)

dorsal pharyngeal muscle primordium

(Fisher et al., 2012)

head visceral muscle primordium

(Fisher et al., 2012)

organism | faint | ubiquitous

(Fisher et al., 2012)

posterior midgut primordium

(Fisher et al., 2012)

somatic muscle primordium

Comment: reported as muscle system primordium

(Fisher et al., 2012)

visceral muscle primordium

Comment: reported as muscle system primordium

(Fisher et al., 2012)

wandering third instar larval stage

wing pouch | restricted

(Molnar et al., 2012)

wing hinge primordium | restricted

(Molnar et al., 2012)

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Polypeptide Expression

mass spectroscopy

Stage

Tissue/Position (including subcellular localization)

Reference

day 5 of adulthood & male -- day 7 of adulthood & male

spermatozoon

(Wasbrough et al., 2010, Dorus et al., 2006)

day 7 of adulthood -- day 49 of adulthood

adult heart

(Cammarato et al., 2011)

adult stage

adult head

• membrane

(Aradska et al., 2015)

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Evidence

References

located_in mitochondrion

inferred from high throughput direct assay

(Alonso et al., 2005)

Expression Deduced from Reporters

High-Throughput Expression Data

Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\SdhA in GBrowse 2

RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region

View exonic expression by developmental stage for Dmel\SdhA

View exonic expression by tissue for Dmel\SdhA

Bulk Downloads

RNA-Seq RPKM values for all genes

Reference

See Gelbart and Emmert, 2013 for analysis details and data files for all genes.

Developmental Proteome: Life Cycle

Developmental Proteome: Embryogenesis

External Data and Images

Linkouts

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0261439

FLIGHT - Cell culture data for RNAi and other high-throughput technologies

FBgn0261439

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG17246

Images

FlyBase Wiki

Image Based Resources

Alleles, Insertions, Transgenic Constructs, and Aberrations

Classical and Insertion Alleles ( 16 )

For All Classical and Insertion Alleles Show

Other relevant insertions

Transgenic Constructs ( 6 )

For All Alleles Carried on Transgenic Constructs Show

Transgenic constructs containing/affecting coding region of SdhA

Transgenic constructs containing regulatory region of SdhA

Aberrations (Deficiencies and Duplications) ( 0 )

Inferred from experimentation

Inferred from location

Phenotypes

For more details about a specific phenotype click on the relevant allele symbol.

Lethality

Allele

lethal

lethal, with Scer\GAL4^Mef2.PU

SdhA^KK101728

lethal | heat sensitive

SdhA⁸

lethal | recessive

lethal - all die during first instar larval stage | recessive

SdhA^LA374

viable

SdhA²

viable, with Scer\GAL4^nSyb.PS

SdhA^KK101728

viable, with Scer\GAL4^repo.PU

SdhA^KK101728

Other Phenotypes

Allele

abnormal neurophysiology | adult stage

Phenotype manifest in

Allele

eye photoreceptor cell | somatic clone

mitochondrion & eye photoreceptor cell | somatic clone

SdhA¹¹¹⁰

ommatidium | somatic clone

SdhA¹¹¹⁰

ovariole, with Scer\GAL4^bab1-Pgal4-2

SdhA^KK101728

ovariole, with Scer\GAL4^tj.PU

SdhA^KK101728

photoreceptor cell R7

SdhA^LA374

photoreceptor cell R8

SdhA^LA374

retina | somatic clone

SdhA¹¹¹⁰

rhabdomere | somatic clone

SdhA¹¹¹⁰

Orthologs

Downloads

Download All DIOPT Orthologs

Download All OrthoDB Orthologs

Human Orthologs (via DIOPT v8.0)

Homo sapiens (Human) (1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Hsap\SDHA

15 of 15

Yes

Model Organism Orthologs (via DIOPT v8.0)

Mus musculus (laboratory mouse) (1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Mmus\Sdha

14 of 15

Yes

Rattus norvegicus (Norway rat) (1)

Rnor\Sdha

12 of 13

Yes

Xenopus tropicalis (Western clawed frog) (1)

Xtro\sdha

13 of 12

Yes

Danio rerio (Zebrafish) (1)

Drer\sdha

14 of 15

Yes

Caenorhabditis elegans (Nematode, roundworm) (2)

Cele\sdha-1

14 of 15

Yes

Cele\sdha-2

12 of 15

Yes

Arabidopsis thaliana (thale-cress) (3)

Atha\SDH1-1

9 of 9

Yes

Atha\SDH1-2

8 of 9

Yes

Atha\AO

1 of 9

Yes

Saccharomyces cerevisiae (Brewer's yeast) (4)

Scer\SDH1

13 of 15

Yes

Scer\YJL045W

13 of 15

Yes

Scer\FRD1

2 of 15

Yes

Scer\OSM1

2 of 15

Yes

Schizosaccharomyces pombe (Fission yeast) (1)

Spom\sdh1

11 of 12

Yes

Ortholog(s) in Drosophila Species (via OrthoDB v9.1) ( EOG091903UH )

Organism

Common Name

Gene

AAA Syntenic Ortholog

Multiple Dmel Genes in this Orthologous Group

Drosophila suzukii

Spotted wing Drosophila

Drosophila simulans

Drosophila sechellia

Drosophila erecta

Drosophila yakuba

Drosophila ananassae

Drosophila pseudoobscura pseudoobscura

Dpse\GA14410

Drosophila persimilis

Dper\GL11254

Drosophila willistoni

Dwil\GK22213

Drosophila virilis

Dvir\GJ21546

Drosophila mojavensis

Dmoj\GI18459

Drosophila grimshawi

Dgri\GH22974

Orthologs in non-Drosophila Dipterans (via OrthoDB v9.1) ( EOG0915025O )

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Musca domestica

House fly

Mdoa\17021293

Lucilia cuprina

Australian sheep blowfly

Lcup\FF38_12166

Mayetiola destructor

Hessian fly

Mdes\Mdes000023

Aedes aegypti

Yellow fever mosquito

Aaeg\AAEL010608

Anopheles darlingi

American malaria mosquito

Adar\ADAC000022

Anopheles gambiae

Malaria mosquito

Agam\AGAP010429

Culex quinquefasciatus

Southern house mosquito

Cqui\CPIJ006167

Orthologs in non-Dipteran Insects (via OrthoDB v9.1) ( EOG090W01XW )

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Bombyx mori

Silkmoth

Bmor\BGIBMGA009000

Bombyx mori

Silkmoth

Bmor\BGIBMGA012226

Danaus plexippus

Monarch butterfly

Dple\DPOGS200427-PA

Danaus plexippus

Monarch butterfly

Dple\DPOGS203282-PA

Heliconius melpomene

Postman butterfly

Hmel\HMEL002503

Apis florea

Little honeybee

Aflo\2185572500

Apis florea

Little honeybee

Aflo\2553398020

Apis mellifera

Western honey bee

Amel\SdhA

Apis mellifera

Western honey bee

Amel\GB47042

Bombus impatiens

Common eastern bumble bee

Bimp\BIMP10486

Bombus impatiens

Common eastern bumble bee

Bimp\BIMP10487

Bombus terrestris

Buff-tailed bumblebee

Bter\15203280

Bombus terrestris

Buff-tailed bumblebee

Bter\15203459

Linepithema humile

Argentine ant

Lhum\LH26193

Linepithema humile

Argentine ant

Lhum\LH26194

Megachile rotundata

Alfalfa leafcutting bee

Mrot\MROTU:001c29

Megachile rotundata

Alfalfa leafcutting bee

Mrot\MROTU:001c27

Nasonia vitripennis

Parasitic wasp

Nvit\Nasvi2EG005214

Nasonia vitripennis

Parasitic wasp

Nvit\Nasvi2EG005216

Dendroctonus ponderosae

Mountain pine beetle

Dpod\YQE_05566

Dendroctonus ponderosae

Mountain pine beetle

Dpod\YQE_05339

Tribolium castaneum

Red flour beetle

Tcas\TC006271

Tribolium castaneum

Red flour beetle

Tcas\GLEAN_07374

Pediculus humanus

Human body louse

Phum\PHUM530140

Rhodnius prolixus

Kissing bug

Rpro\RPRC013824

Cimex lectularius

Bed bug

Clec\CLEC000845

Cimex lectularius

Bed bug

Clec\CLEC013787

Acyrthosiphon pisum

Pea aphid

Apim\ACYPI007401

Zootermopsis nevadensis

Nevada dampwood termite

Znev\Znev_11125

Orthologs in non-Insect Arthropods (via OrthoDB v9.1) ( EOG090X01VH )

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Strigamia maritima

European centipede

Smar\SMAR002835

Ixodes scapularis

Black-legged tick

Isca\ISCW016038

Ixodes scapularis

Black-legged tick

Isca\ISCW000555

Stegodyphus mimosarum

African social velvet spider

Smim\KFM81245.1

Tetranychus urticae

Two-spotted spider mite

Turt\tetur08g03210

Daphnia pulex

Water flea

Dpux\DAPPUDRAFT_114606

Daphnia pulex

Water flea

Dpux\DAPPUDRAFT_117582

Daphnia pulex

Water flea

Dpux\DAPPUDRAFT_228809

Orthologs in non-Arthropod Metazoa (via OrthoDB v9.1) ( EOG091G041Z )

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Strongylocentrotus purpuratus

Purple sea urchin

Spur\Sp-Sdha_1

Strongylocentrotus purpuratus

Purple sea urchin

Spur\Sp-Sdha

Ciona intestinalis

Vase tunicate

Cint\LOC100183000

Gallus gallus

Domestic chicken

Ggal\SDHA

Paralogs

Downloads

Download All DIOPT Paralogs

Paralogs (via DIOPT v8.0)

Drosophila melanogaster (Fruit fly) (1)

Gene Symbol

Score

Source

Alignment

7 of 10

Human Disease Associations

FlyBase Human Disease Model Reports

mitochondrial complex II deficiency, SDHA/B-related

Disease Model Summary Ribbon

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Allele

Disease

Evidence

References

Potential Models Based on Orthology ( 4 )

Human Ortholog

Disease

Evidence

References

SDHA; succinate dehydrogenase complex flavoprotein subunit A

model of Leigh disease

IEA

(FlyBase, 2019-)

model of mitochondrial complex II deficiency

IEA

(FlyBase, 2019-)

model of paraganglioma

IEA

(FlyBase, 2019-)

model of dilated cardiomyopathy 1GG

IEA

(FlyBase, 2019-)

Modifiers Based on Experimental Evidence ( 0 )

Allele

Disease

Interaction

References

Disease Associations of Human Orthologs (via DIOPT v8.0 and OMIM)

Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.

Homo sapiens (Human)

Gene name

Score

OMIM

OMIM Phenotype

DO term

Complementation?

Transgene?

SDHA; succinate dehydrogenase complex flavoprotein subunit A

15 of 15

600857

Functional Complementation Data

Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.

Interactions

Summary of Physical Interactions

esyN Network Diagram

Interactions Browser

View in Interactions Browser

Please see the Physical Interaction reports below for full details

RNA-protein

Physical Interaction

Assay

References

SdhA - smg

anti bait coimmunoprecipitation, primer specific pcr

(Chartier et al., 2015)

protein-protein

Physical Interaction

Assay

References

SdhA - CG14036

experimental knowledge based

(Guruharsha et al., 2011)

SdhA - CG1532

experimental knowledge based

(Guruharsha et al., 2011)

SdhA - CG18789

experimental knowledge based

(Guruharsha et al., 2011)

SdhA - Ccs

experimental knowledge based

(Guruharsha et al., 2011)

SdhA - SdhB

blue native page, peptide massfingerprinting

(Rahman et al., 2014)

Summary of Genetic Interactions

esyN Network Diagram

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

External Data

Subunit Structure (UniProtKB)

Component of complex II composed of four subunits: a flavoprotein (FP), an iron-sulfur protein (IP), and a cytochrome b composed of a large and a small subunit.

(UniProt, Q94523 )

Linkouts

DroID - A comprehensive database of gene and protein interactions.

FBgn0261439

InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.

37228

MIST (protein-protein) - An integrated Molecular Interaction Database

SdhA

Pathways

Signaling Pathways (FlyBase)

Metabolic Pathways

External Data

Linkouts

KEGG Pathways - Wiring diagrams of molecular interactions, reactions and relations.

Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.

Citric acid cycle (TCA cycle)

Genomic Location and Detailed Mapping Data

Chromosome (arm)

Recombination map

2-89

Cytogenetic map

56D3-56D3

Sequence location

2R:19,391,863..19,395,971 [-]

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

56D3-56D3

Limits computationally determined from genome sequence between P{PZ}ena⁰²⁰²⁹&P{lacW}cora^k08713 and P{lacW}hts^k06121

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

56D1-56D1

(Caggese, 1996.10.24)

56D1-56D2

(determined by in situ hybridisation)

(Caggese et al., 1999)

Experimentally Determined Recombination Data

Location

2-89

(FlyBase, 2016)

2-94.5

(Comeron et al., 2012)

(Caggese, 1996.10.24)

Left of (cM)

Right of (cM)

M(2)53

Notes

Mapping based on 199 M(2)53-bw recombinants.

Stocks and Reagents

Stocks (12)

Bloomington

43481

w^*; P{GSV1}SdhA^s-153.1

22087

w¹¹¹⁸; P{EPg}SdhA^HP21216/CyO

51659

SdhA¹¹¹⁰/CyO, P{GAL4-Kr.C}DC3, P{UAS-GFP.S65T}DC7

81120

SdhA¹⁴⁰⁴/CyO, P{GAL4-Kr.C}DC3, P{UAS-GFP.S65T}DC7

1563

cn¹ SdhA⁵ bw¹ speck¹/CyO

76447

y¹ sc^* v¹ sev²¹; P{TKO.GS00620}attP40

78294

y¹ sc^* v¹ sev²¹; P{TOE.GS02376}attP40

82425

y^d2 w¹¹¹⁸ P{ey-FLP.N}2 P{5xglBS-lacZ.38-1}TPN1; P{neoFRT}42D SdhA^JQ171/CyO, P{GAL4-Kr.C}DC3, P{UAS-GFP.S65T}DC7

82426

y^d2 w¹¹¹⁸ P{ey-FLP.N}2 P{5xglBS-lacZ.38-1}TPN1; P{neoFRT}42D SdhA^LA374/CyO, P{GAL4-Kr.C}DC3, P{UAS-GFP.S65T}DC7

Kyoto

114703

y^d2 w¹¹¹⁸ P{ey-FLP.N}2; P{neoFRT}42D P{EPg}SdhA^HP21216 /CyO y⁺

VDRC

v330053

P{VSH330053}attP40

v110440

P{KK101728}VIE-260B

Genomic Clones (19)

Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

cDNA Clones (112)

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequenced

BDGP DGC clones

GH13919

Other clones

RE33070

Drosophila Genomics Resource Center cDNA clones

For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

FBgn0261439

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

Other clones

RNAi and Array Information

Linkouts

DRSC - Results frm RNAi screens

FBgn0261439

GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents

37228

Antibody Information

Laboratory Generated Antibodies

polyclonal

(Murari et al., 2020)

Commercially Available Antibodies

Other Information

Relationship to Other Genes

Source for database identify of

Source for database merge of

Source for merge of: Sdh Scs-fp

(Mast et al., 2008)

Additional comments

Other Comments

Origin and Etymology

Discoverer

Etymology

Identification

External Crossreferences and Linkouts ( 48 )

Sequence Crossreferences

NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.

37228

GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.

GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.

RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.

UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information

Q94523

Other crossreferences

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0261439

Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones

FBgn0261439

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

SdhA_1

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG17246

FlyMine - An integrated database for Drosophila genomics

FBgn0261439

GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents

37228

iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)

TC006271

InterPro - A database of protein families, domains and functional sites

KEGG Genes - Molecular building blocks of life in the genomic space.

Dmel_CG17246

modMine - A data warehouse for the modENCODE project

FBgn0261439

Linkouts

DPiM - Drosophila Protein interaction map

FBgn0261439

DroID - A comprehensive database of gene and protein interactions.

FBgn0261439

DRSC - Results frm RNAi screens

FBgn0261439

FLIGHT - Cell culture data for RNAi and other high-throughput technologies

FBgn0261439

InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.

37228

KEGG Pathways - Wiring diagrams of molecular interactions, reactions and relations.

MIST (protein-protein) - An integrated Molecular Interaction Database

SdhA

Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.

Citric acid cycle (TCA cycle)

Synonyms and Secondary IDs (25)

Reported As

Symbol Synonym

2R1

(Bellen, 2020.5.15)

CG17246

(Murari et al., 2020, Kolkhof et al., 2017, Meadows, 2017.1.11, Rosa-Ferreira et al., 2015, Volkenhoff et al., 2015, McEachern et al., 2014, Jaspers et al., 2012, Cammarato et al., 2011, Ling and Salvaterra, 2011, Blagden et al., 2009, Keleman et al., 2009.8.5, Pan and Zhang, 2009, Mast et al., 2008, Porcelli et al., 2007, Caggese et al., 2006)

DHSA

(Caggese et al., 2006)

SDH

(Prasad and Muralidhara, 2014)

Scs-fp

(Japanese National Institute of Genetics, 2012.5.21, Tiefenböck et al., 2010, Langille and Clark, 2007, Caggese et al., 2006, Dorus et al., 2006, Alonso et al., 2005, Tripoli et al., 2005)

Sdh

(de la Cova et al., 2014)

Sdh A

(Kanda et al., 2011)

Sdha

(Drelon et al., 2018, Ling and Salvaterra, 2011)

dSDHA

(Murari et al., 2020)

scs-fp

(Comas et al., 2004)

sdh

(Lerner et al., 2015, Denholm et al., 2003, Fyrberg et al., 1994)

sdhA

(Fan et al., 2019)

Name Synonyms

COMPLEX II: flavoprotein subunit

(Porcelli et al., 2007)

SUCCINYL COENZIME A SYNTHETASE FLAVOPROTEIN SUBUNIT

(Alonso et al., 2005)

Succinate dehydrogenase

(Feng et al., 2015)

Succinate dehydrogenase A

(McEachern et al., 2014, Ling and Salvaterra, 2011)

Succinate dehydrogenase Flavoprotein

(Porcelli et al., 2007)

Succinate dehydrogenase Flavoprotein subunit

(Tripoli et al., 2005)

Succinate dehydrogenase [ubiquinone] flavoprotein subunit

(Caggese et al., 2006)

Succinate dehydrogenase, subunit A (flavoprotein)

(Porcelli and Marygold, 2014.9.16)

Succinyl coenzyme A synthetase flavoprotein subunit

(Jaspers et al., 2012, Cammarato et al., 2011)

succinate dehydrogenase

(Park et al., 2018, de la Cova et al., 2014, Celotto et al., 2011)

succinate dehydrogenase flavoprotein subunit

(Mast et al., 2008, Caggese, 1996.10.24)

succinyl CoA synthetase flavoprotein subunit of complex II

(Tiefenböck et al., 2010)

Secondary FlyBase IDs

FBgn0003347
FBgn0017539

Datasets (0)

Study focus (0)

Experimental Role

Project

Project Type

Title

References (93)

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