FlyBase Gene Report: Dmel\sgl

General Information

Symbol

Dmel\sgl

Species

D. melanogaster

Name

sugarless

Annotation Symbol

CG10072

Feature Type

protein_coding_gene

FlyBase ID

FBgn0261445

Gene Model Status

Current

Stock Availability

24 publicly available

Enzyme Name (EC)

UDP-glucose 6-dehydrogenase (1.1.1.22)

Gene Summary

Involved in the biosynthesis of glycosaminoglycans; hyaluronan, chondroitin sulfate and heparan sulfate. Required for wingless signaling in different tissues. (UniProt, O02373)

Contribute a Gene Snapshot for this gene.

All Summaries

Alliance
Auto summary
Gene Group
UniProtKB
Interactive Fly

Also Known As

kiwi, suppenkasper, ska, UDPGDH, UDP-GlcDH

Key Links

Genomic Location

Cytogenetic map

65D4-65D5

Sequence location

3L:6,959,554..6,964,758 [-]

Recombination map

3-18

RefSeq locus

NT_037436 REGION:6959554..6964758

Sequence

Get Decorated FASTA

Genomic Maps

JBrowse GBrowse

Help me choose

Other Genome Views

The following external sites may use different assemblies or annotations than FlyBase.

Function

GO Summary Ribbons

Gene Ontology (GO) Annotations (11 terms)

Molecular Function (2 terms)

Terms Based on Experimental Evidence (1 term)

CV Term

Evidence

References

enables UDP-glucose 6-dehydrogenase activity

inferred from mutant phenotype

(assigned by UniProt )

(Toyoda et al., 2000)

Terms Based on Predictions or Assertions (1 term)

CV Term

Evidence

References

enables NAD binding

inferred from electronic annotation with InterPro:IPR001732, InterPro:IPR014026, InterPro:IPR014027

(assigned by InterPro )

(FlyBase Curators et al., 2004-)

Biological Process (7 terms)

Terms Based on Experimental Evidence (7 terms)

CV Term

Evidence

References

involved_in chondroitin sulfate biosynthetic process

inferred from mutant phenotype

(assigned by UniProt )

(Toyoda et al., 2000)

involved_in epithelial cell migration, open tracheal system

inferred from mutant phenotype

(assigned by UniProt )

(Lin et al., 1999)

inferred from genetic interaction with UniProtKB:Q09147

(assigned by UniProt )

(Lin et al., 1999)

acts_upstream_of_positive_effect fibroblast growth factor receptor signaling pathway

inferred from mutant phenotype

(assigned by UniProt )

(Lin et al., 1999)

inferred from genetic interaction with UniProtKB:Q07407

(assigned by UniProt )

(Lin et al., 1999)

involved_in glycosaminoglycan biosynthetic process

inferred from mutant phenotype

(assigned by UniProt )

(Toyoda et al., 2000)

involved_in heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process

inferred from mutant phenotype

(assigned by UniProt )

(Toyoda et al., 2000)

involved_in mesoderm migration involved in gastrulation

inferred from mutant phenotype

(assigned by UniProt )

(Lin et al., 1999)

involved_in segment polarity determination

inferred from mutant phenotype

(Zhu et al., 2005)

Terms Based on Predictions or Assertions (1 term)

CV Term

Evidence

References

involved_in glycosaminoglycan biosynthetic process

inferred from biological aspect of ancestor with PANTHER:PTN000146693

(assigned by GO_Central )

(Gaudet et al., 2011)

Cellular Component (2 terms)

Terms Based on Experimental Evidence (0 terms)

Terms Based on Predictions or Assertions (2 terms)

CV Term

Evidence

References

is_active_in cytosol

inferred from biological aspect of ancestor with PANTHER:PTN000146693

(assigned by GO_Central )

(Gaudet et al., 2011)

is_active_in nucleus

inferred from biological aspect of ancestor with PANTHER:PTN000146693

(assigned by GO_Central )

(Gaudet et al., 2011)

Gene Group (FlyBase)

OTHER CH-OH OXIDOREDUCTASES, NAD OR NADP AS ACCEPTOR

Protein Family (UniProt)

Belongs to the UDP-glucose/GDP-mannose dehydrogenase family. (O02373)

Protein Signatures (InterPro)

Catalytic Activity (EC)

Experimental Evidence

UDP-glucose + 2 NAD(+) + H(2)O = UDP-glucuronate + 2 NADH (1.1.1.22)

Predictions / Assertions

Summaries

Gene Group (FlyBase)

OTHER CH-OH OXIDOREDUCTASES, NAD OR NADP AS ACCEPTOR -: The Other CH-OH oxidoreductases, NAD or NADP as acceptor group, is a collection of oxidoreductases that do not fit into any of the other major CH-OH oxidoreductases, NAD or NADP as acceptor group.

Protein Function (UniProtKB)

Involved in the biosynthesis of glycosaminoglycans; hyaluronan, chondroitin sulfate and heparan sulfate. Required for wingless signaling in different tissues.

(UniProt, O02373)

Gene Model and Products

Number of Transcripts

Number of Unique Polypeptides

Please see the JBrowse view of Dmel\sgl for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)

Isoform displayed:

Pfam protein domains

InterPro name

classification

start

end

Protein Domains (via SMART)

Isoform displayed:

SMART protein domains

InterPro name

classification

start

end

Structure New Section

Protein 3D structure (Predicted by AlphaFold) (AlphaFold entry O02373)

If you don't see the viewer to the right, refresh your browser.

Model Confidence:

Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Comments on Gene Model

Gene model reviewed during 5.46

Sequence Ontology: Class of Gene

gene

(Sambandan et al., 2006)

nuclear_gene

protein_coding_gene

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Assoc. CDS (aa)

sgl-RA

FBtr0076938

NM_057632

2275

476

Additional Transcript Data and Comments

Reported size (kB)

2.4 (northern blot)

(Binari et al., 1997)

2.3 (northern blot)

(Hacker et al., 1997, Haerry et al., 1997)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kDa)

Length (aa)

Theoretical pI

RefSeq ID

GenBank

sgl-PA

FBpp0076647

52.9

476

6.08

NP_476980

AAF50631

Polypeptides with Identical Sequences

There is only one protein coding transcript and one polypeptide associated with this gene

Additional Polypeptide Data and Comments

Reported size (kDa)

476 (aa)

(Binari et al., 1997, Hacker et al., 1997)

476 (aa); 53 (kD predicted)

(Haerry et al., 1997)

Comments

External Data

Crossreferences

InterPro - A database of protein families, domains and functional sites

Linkouts

Sequences Consistent with the Gene Model

Nucleotide / Polypeptide Records

UniProt

Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\sgl using the Feature Mapper tool.

External Data

Crossreferences

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

sgl_1

Linkouts

Expression Data

Expression Summary Ribbons

Colored tiles in ribbon indicate that expression data has been curated by FlyBase for that anatomical location. Colorless tiles indicate that there is no curated data for that location.

For complete stage-specific expression data, view the modENCODE Development RNA-Seq section under High-Throughput Expression below.

Transcript Expression

No Assay Recorded

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage

(Hacker et al., 1997)

in situ

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage 1 -- 3

organism | ubiquitous

(Binari et al., 1997)

organism

Comment: maternally deposited

(Fisher et al., 2012)

embryonic stage 3

organism | ubiquitous

(Haerry et al., 1997)

embryonic stage 4 -- 6

organism | ubiquitous

(Fisher et al., 2012)

embryonic stage 7 -- 8

amnioserosa

(Fisher et al., 2012)

organism | faint | ubiquitous

(Fisher et al., 2012)

extended germ band stage

mesoderm

(Haerry et al., 1997)

embryonic stage 9 -- 10

amnioserosa

(Fisher et al., 2012)

head mesoderm

(Fisher et al., 2012)

organism | faint | ubiquitous

(Fisher et al., 2012)

embryonic stage 9 -- 14

amnioserosa | presumptive

(Binari et al., 1997)

embryonic stage 10 -- 17

cephalic furrow | surrounding

(Binari et al., 1997)

embryonic stage 11 -- 12

amnioserosa

(Fisher et al., 2012)

organism | faint | ubiquitous

(Fisher et al., 2012)

plasmatocyte primordium

Comment: reported as plasmatocytes anlage

(Fisher et al., 2012)

procrystal cell

(Fisher et al., 2012)

embryonic stage 13

embryonic/larval midgut

(Haerry et al., 1997)

embryonic stage 16 -- 17

embryonic/larval proventriculus

(Haerry et al., 1997)

embryonic/larval hindgut

(Haerry et al., 1997)

embryonic stage 17

embryonic/larval pharynx

(Haerry et al., 1997)

third instar larval stage

eye disc morphogenetic furrow

(Haerry et al., 1997)

imaginal disc

(Haerry et al., 1997)

Additional Descriptive Data

sgl transcript is distributed uniformly in the embryo before stage 4. By stage 9, sgl expression has become restricted to the areas surrounding the cephalic furrow, and the presumptive amnioserosa. Expression in the amnioserosa persists at least until stage 14 of embryogenesis.

(Binari et al., 1997)

sgl is expressed both maternally and ubiquitously throughout embryonic development.

(Hacker et al., 1997)

sgl transcript is found in the early embryo. After germ band extension, signal is more intense in the mesoderm. After germ band retraction, sgl is expressed in the midgut. After dorsal closure, sgl expression is detected in the pharynx and hindgut. sgl is detected ubiquitously in most third instar larval imaginal discs. Low levels of sgl are detected in the eye imaginal disc, with the highest concentration found in the morphogenetic furrow.

(Haerry et al., 1997)

Marker for

Subcellular Localization

CV Term

Polypeptide Expression

mass spectroscopy

Stage

Tissue/Position (including subcellular localization)

Reference

adult stage

adult head

• membrane

(Aradska et al., 2015)

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Evidence

References

Expression Deduced from Reporters

High-Throughput Expression Data

Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\sgl in GBrowse 2

RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region

View exonic expression by developmental stage for Dmel\sgl

View exonic expression by tissue for Dmel\sgl

Bulk Downloads

RNA-Seq RPKM values for all genes

Reference

See Gelbart and Emmert, 2013 for analysis details and data files for all genes.

Developmental Proteome: Life Cycle

Developmental Proteome: Embryogenesis

External Data and Images

Linkouts

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0261445

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

38760/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0261445

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0010851

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0261445

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG10072

Images

FlyBase Wiki

Image Based Resources

Alleles, Insertions, Transgenic Constructs, and Aberrations

Classical and Insertion Alleles ( 38 )

For All Classical and Insertion Alleles Show

Other relevant insertions

Transgenic Constructs ( 8 )

For All Alleles Carried on Transgenic Constructs Show

Transgenic constructs containing/affecting coding region of sgl

Transgenic constructs containing regulatory region of sgl

Aberrations (Deficiencies and Duplications) ( 6 )

Inferred from experimentation ( 6 )

Gene disrupted in

Df(3L)BSC27

(Deal et al., 2002.12.17)

Df(3L)vvl7247-Mis12

(Sotillos et al., 2010)

Df(3L)W5.4

(Benevolenskaya et al., 1998, Hacker et al., 1997, Anderson et al., 1995)

Gene not disrupted in

Df(3L)XAS96

(Anderson et al., 1995)

Df(3L)XBB70

(Anderson et al., 1995)

Df(3L)ZN47

(Spradling et al., 1999, BDGP Project Members, 1994-1999)

Inferred from location ( 0 )

Alleles Representing Disease-Implicated Variants

Phenotypes

For more details about a specific phenotype click on the relevant allele symbol.

Lethality

Allele

lethal | larval stage | recessive

sgl⁰⁸³¹⁰

lethal | recessive

partially lethal | recessive | rescuable maternal effect

sgl⁰⁸³¹⁰

partially lethal - majority die

sgl⁰⁵⁰⁰⁷

partially lethal - majority die | recessive

sgl⁰⁵⁰⁰⁷

viable

viable, with Dcr-2^UAS.cDa, Scer\GAL4^elav.PLu

sgl^GD14861

viable, with Scer\GAL4^Mef2.PR

sgl^GD14861

viable, with Scer\GAL4^pnr-MD237

sgl^GD14861

viable, with Scer\GAL4^tin.CΔ4

sgl^GD14861

Sterility

Allele

fertile

sgl^EY04671

Other Phenotypes

Allele

abnormal behavior | recessive

sgl^BG01214

abnormal locomotor behavior | third instar larval stage, with Scer\GAL4^da.G32

sgl^UY771

abnormal neuroanatomy | third instar larval stage, with Scer\GAL4^da.G32

sgl^UY771

chemical resistant, with Scer\GAL4^da.G32

sgl^UY771

increased cell number | adult stage, with Scer\GAL4^esg.PU

sgl^HMC06100

increased occurrence of cell division | adult stage, with Scer\GAL4^esg.PU

sgl^HMC06100

segment polarity phenotype | germline clone

sgl⁰⁸³¹⁰

segment polarity phenotype | partially | recessive | rescuable maternal effect

sgl⁰⁸³¹⁰

some die during embryonic stage | rescuable maternal effect

sgl⁰⁸³¹⁰

visible | somatic clone

sgl⁰⁸³¹⁰

wild-type

sgl^Ubi-p63E.PH

Phenotype manifest in

Allele

adult midgut epithelium, with Scer\GAL4^esg.PU

sgl^HMC06100

adult mushroom body alpha'-lobe

sgl^BG01214

adult mushroom body alpha-lobe

sgl^BG01214

adult mushroom body beta'-lobe

sgl^BG01214

adult mushroom body beta-lobe

sgl^BG01214

cuticle

sgl⁰⁸³¹⁰

denticle belt

sgl⁰⁸³¹⁰

denticle belt | germline clone

sgl⁰⁸³¹⁰

embryo | germline clone

sgl⁰⁸³¹⁰

embryonic/first instar larval cuticle

sgl⁰⁸³¹⁰

embryonic/first instar larval cuticle | dorsal

sgl⁰⁸³¹⁰

embryonic/first instar larval cuticle | germline clone

sgl⁰⁸³¹⁰

embryonic/larval ganglionic tracheal branch

sgl⁰⁸³¹⁰

embryonic/larval neuromuscular junction | third instar larval stage, with Scer\GAL4^da.G32

sgl^UY771

embryonic/larval tracheal dorsal trunk

sgl⁰⁸³¹⁰

embryonic/larval tracheal lateral trunk

sgl⁰⁸³¹⁰

embryonic/larval tracheal system

sgl⁰⁸³¹⁰

embryonic/larval tracheal system | germline clone

sgl⁰⁸³¹⁰

embryonic Malpighian tubule | germline clone

sgl⁰⁸³¹⁰

embryonic midgut constriction 2 | germline clone

sgl⁰⁸³¹⁰

eye-antennal disc

imaginal disc | larval stage

sgl^SG9

imaginal disc | P-stage

sgl^SG9

macrochaeta

sgl^BG01914

mesoderm | germline clone

sgl⁰⁸³¹⁰

NMJ bouton | third instar larval stage, with Scer\GAL4^da.G32

sgl^UY771

segment | ventral

sgl⁰⁸³¹⁰

stomodeal invagination | germline clone

sgl⁰⁸³¹⁰

synapse | third instar larval stage, with Scer\GAL4^da.G32

sgl^UY771

wing

sgl^W27

wing | somatic clone

sgl⁰⁸³¹⁰

wing margin bristle | somatic clone

sgl⁰⁸³¹⁰

wing margin taste bristle | decreased number, with Scer\GAL4^rn-GAL4-13

sgl^{UAS.ORF.Tag:HA}

Orthologs

Downloads

Download All DIOPT Orthologs

Human Orthologs (via DIOPT v8.0)

Homo sapiens (Human) (16)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Hsap\UGDH

15 of 15

Yes

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

Model Organism Orthologs (via DIOPT v8.0)

Mus musculus (laboratory mouse) (15)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Mmus\Ugdh

13 of 15

Yes

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

Rattus norvegicus (Norway rat) (16)

Rnor\Ugdh

13 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Yes

Rnor\Plcl1

1 of 13

Yes

Rnor\Plcl2

1 of 13

Rnor\Plcz1

1 of 13

Xenopus tropicalis (Western clawed frog) (18)

Xtro\ugdh

13 of 12

Yes

Xtro\ugdh.2

12 of 12

Yes

Xtro\LOC100488276

1 of 12

Yes

Xtro\LOC100496658

1 of 12

Yes

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

Yes

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

Yes

Xtro\plcl2

1 of 12

Danio rerio (Zebrafish) (23)

Drer\ugdh

15 of 15

Yes

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

Yes

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

Yes

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

Drer\si:ch211-210g13.5

1 of 15

Drer\si:ch211-260p9.3

1 of 15

Caenorhabditis elegans (Nematode, roundworm) (7)

Cele\sqv-4

14 of 15

Yes

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

Arabidopsis thaliana (thale-cress) (14)

Atha\UDG4

9 of 9

Yes

Atha\UGD2

9 of 9

Yes

Atha\UGD3

9 of 9

Yes

Atha\UGD1

8 of 9

Yes

Atha\AT3G01010

2 of 9

Yes

1 of 9

1 of 9

1 of 9

1 of 9

1 of 9

1 of 9

1 of 9

1 of 9

1 of 9

Saccharomyces cerevisiae (Brewer's yeast) (0)

No records found.

Schizosaccharomyces pombe (Fission yeast) (0)

No records found.

Other Organism Orthologs (via OrthoDB)

Paralogs

Downloads

Download All DIOPT Paralogs

Paralogs (via DIOPT v8.0)

Drosophila melanogaster (Fruit fly) (1)

Gene Symbol

Score

Source

Alignment

1 of 10

Human Disease Associations

FlyBase Human Disease Model Reports

Disease Model Summary Ribbon

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Allele

Disease

Evidence

References

Potential Models Based on Orthology ( 1 )

Human Ortholog

Disease

Evidence

References

UGDH; UDP-glucose 6-dehydrogenase

model of developmental and epileptic encephalopathy 84

IEA

(FlyBase, 2019-)

Modifiers Based on Experimental Evidence ( 1 )

Allele

Disease

Interaction

References

sgl^UY771

ameliorates galactosemia

modeled by Galt^Δ1AP2

(Jumbo-Lucioni et al., 2014)

Disease Associations of Human Orthologs (via DIOPT v8.0 and OMIM)

Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.

Homo sapiens (Human)

Gene name

Score

OMIM

OMIM Phenotype

DO term

Complementation?

Transgene?

UGDH; UDP-glucose 6-dehydrogenase

15 of 15

603370

DEVELOPMENTAL AND EPILEPTIC ENCEPHALOPATHY 84; DEE84

developmental and epileptic encephalopathy 84

Functional Complementation Data

Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.

Interactions

Summary of Physical Interactions

esyN Network Diagram

Interactions Browser

View in Interactions Browser

Please see the Physical Interaction reports below for full details

protein-protein

Physical Interaction

Assay

References

sgl - nmo

experimental knowledge based

(Guruharsha et al., 2011)

Summary of Genetic Interactions

esyN Network Diagram

esyN Network Key:

Suppression

Enhancement

View in Interactions Browser

Please look at the allele data for full details of the genetic interactions

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

sgl

suppressible

bnl

(Lin et al., 1999)

sgl|w

enhanceable

(Benevolenskaya et al., 1998)

sgl

suppressible

htl

(Lin et al., 1999)

sgl

suppressible

(Binari et al., 1997)

sgl|w

suppressible

(Benevolenskaya et al., 1998)

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

suppressible

(Lin et al., 1999)

enhanceable

(Haerry et al., 1997)

Galt

suppressible

sgl

(Jumbo-Lucioni et al., 2014)

Sema1a

enhanceable

sgl

(Cho et al., 2012)

suppressible

sgl

(Moline et al., 2000)

External Data

Linkouts

DroID - A comprehensive database of gene and protein interactions.

FBgn0261445

MIST (genetic) - An integrated Molecular Interaction Database

MIST (protein-protein) - An integrated Molecular Interaction Database

Pathways

Signaling Pathways (FlyBase)

Metabolic Pathways

FlyMet - A comprehensive tissue-specific metabolomics resource for Drosophila.

FBgn0261445

External Data

Linkouts

KEGG Pathways - Wiring diagrams of molecular interactions, reactions and relations.

Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.

Formation of the active cofactor, UDP-glucuronate

Genomic Location and Detailed Mapping Data

Chromosome (arm)

Recombination map

3-18

Cytogenetic map

65D4-65D5

Sequence location

3L:6,959,554..6,964,758 [-]

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

65D4-65D5

Limits computationally determined from genome sequence between P{lacW}l(3)L4060^L4060 and P{PZ}corn⁰⁴²⁰²

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

65D-65D

(determined by in situ hybridisation)

(Weber et al., 2005)

64A-64A

(Haerry, 1997.6.11)

65D4-65D5

(Häcker, 1997.6.17)

65D4-65D6

(Benevolenskaya, 1997.4.25)

65D4-65D5

(determined by in situ hybridisation)

(Spradling et al., 1999, Perrimon et al., 1996)

65D4-65D5

65D4--6

(BDGP Project Members, 1994-1999)

Experimentally Determined Recombination Data

Location

3-18

(FlyBase, 2016)

3-15.8

(Comeron et al., 2012)

3-22.2

Left of (cM)

Right of (cM)

Notes

Stocks and Reagents

Stocks (24)

Aberrations including deletions of this gene Aberrations including duplications of this gene

Bloomington

19916

y¹ w^67c23; P{EPgy2}sgl^EY04671

6767

y¹ w^*; P{Mae-UAS.6.11}sgl^UY771

FlyORF

F001141

M{UAS-sgl.ORF.3xHA}ZH-86Fb

Kyoto

113374

w^*; P{GawB}sgl^NP3616

124016

w¹¹¹⁸; P{RS3}sgl^CB-6278-3

124333

w¹¹¹⁸; P{RS3}sgl^UM-8091-3

125063

w¹¹¹⁸; P{RS5}sgl^5-HA-1090

125064

w¹¹¹⁸; P{RS5}sgl^5-HA-1091

125142

w¹¹¹⁸; P{RS5}sgl^5-HA-1209

125292

w¹¹¹⁸; P{RS5}sgl^5-HA-1605

VDRC

v330451

P{VSH330451}attP40

v29434

w¹¹¹⁸; P{GD14861}v29434

More stocks available...

Genomic Clones (9)

Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

cDNA Clones (71)

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequenced

BDGP DGC clones

Other clones

DPiM_SD09476

Drosophila Genomics Resource Center cDNA clones

For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

FBgn0261445

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

Other clones

RNAi and Array Information

Linkouts

DRSC - Results frm RNAi screens

FBgn0261445

GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents

38760

Antibody Information

Laboratory Generated Antibodies

Commercially Available Antibodies

Other Information

Relationship to Other Genes

Source for database identify of

Source for identity of: sgl CG10072

(Gabrielian, 1999.11)

Source for database merge of

Source for merge of: sgl BG01214

(Edwards et al., 2009)

Additional comments

"kiwi" has been used as a valid symbol for FBgn0020295 and as a synonym for sgl, FBgn0010851.

Other Comments

Loss of both maternal and zygotic sgl function results in profound defects in mesoderm and tracheal cell migration in the embryo.

(Lin et al., 1999)

The levels of glycosaminoglycans (in which sgl plays a role) are rate limiting for cell-cell signalling pathways such as those of wg and hh, which mediate changes in gene expression.

(Benevolenskaya et al., 1998)

Identification: Enhancer trap expression pattern survey for loci expressed in the ring gland.

(Harvie et al., 1998)

sgl has been cloned and sequenced. sgl encodes UDP-glucose dehydrogenase and is required for efficient wg function.

(Binari et al., 1997)

sgl mutations impair signaling by wg protein.

(Hacker et al., 1997)

sgl mutants lack UDP-glucose dehydrogenase activity.

(Haerry et al., 1997)

sgl mutants lack glycosaminoglycan chains on proteoglycans.

(Haerry et al., 1997)

Identified by a P-element mutation with a cuticle phenotype similar to that of wg null alleles.

(Lin et al., 1997)

The autosomal "FLP-DFS" technique (using the P{ovoD1-18} P{FRT(w^hs)} P{hsFLP} chromosomes) has been used to identify the specific maternal effect phenotype for the zygotic lethal mutation.

(Perrimon et al., 1996)

Origin and Etymology

Discoverer

Etymology

Identification

External Crossreferences and Linkouts ( 72 )

Sequence Crossreferences

NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.

38760

GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.

GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.

RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.

UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.

O02373

UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information

O02373

UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information

Q95SJ7

Other crossreferences

AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.

O02373

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0261445

Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones

FBgn0261445

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

38760/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0261445

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

sgl_1

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0010851

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0261445

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG10072

FlyMet - A comprehensive tissue-specific metabolomics resource for Drosophila.

FBgn0261445

FlyMine - An integrated database for Drosophila genomics

FBgn0261445

GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents

38760

iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)

InterPro - A database of protein families, domains and functional sites

KEGG Genes - Molecular building blocks of life in the genomic space.

Dmel_CG10072

MARRVEL_MODEL - MARRVEL (model organism gene)

38760

modMine - A data warehouse for the modENCODE project

FBgn0261445

SignaLink - A signaling pathway resource with multi-layered regulatory networks.

Q95SJ7

Linkouts

ApoDroso - Functional genomic database for photoreceptor development, survival and function

12783-sgl[BG02666]

DroID - A comprehensive database of gene and protein interactions.

FBgn0261445

DRSC - Results frm RNAi screens

FBgn0261445

KEGG Pathways - Wiring diagrams of molecular interactions, reactions and relations.

MIST (genetic) - An integrated Molecular Interaction Database

MIST (protein-protein) - An integrated Molecular Interaction Database

Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.

Formation of the active cofactor, UDP-glucuronate

Synonyms and Secondary IDs (23)

Reported As

Symbol Synonym

8310

(Harvie et al., 1998)

BG01214

(Sambandan et al., 2006)

CG10072

(Meadows, 2019.11.20, Meadows, 2018.4.4, Schertel et al., 2013, Krejcí et al., 2009, Perkins et al., 2009, Norga et al., 2003, Monnier et al., 2002)

Sgl

(Hagen et al., 2021, Jumbo-Lucioni et al., 2010)

UDP-GlcDH

(Scanga et al., 2001, Scanga and Manoukian, 1999)

UDPGDH

(Heslip et al., 2001, Heslip and Marsh, 2000, Benevolenskaya, 1997.4.25, Benevolenskaya, 1997.4.25)

XIII

(Anderson et al., 1995)

kiwi

(Wilson, 2004, Princivalle and de Agostini, 2002, Dale, 1998, Binari et al., 1997, Manoukian, 1997.4.22)

l(3)05007

l(3)08310

l(3)10503

l(3)65CEd

l(3)SG9

(Lindsley and Zimm, 1992)

ska

(Princivalle and de Agostini, 2002, Dale, 1998, Haerry, 1997.6.11, Haerry et al., 1997, Haerry et al., 1997)

(Lin et al., 1997)

Name Synonyms

Distal W5.4 Group XIII

(Anderson et al., 1995)

Sugarless

(Gim et al., 2001)

UDP-glucose 6-dehydrogenase

UDP-glucose dehydrogenase

(Jumbo-Lucioni et al., 2014, Nohynek et al., 1999)

kiwi

(Cumberledge and Reichsman, 1997)

lethal(3)SG9

sugarless

(Hayes and Melrose, 2021, Nagarajan et al., 2015, Jumbo-Lucioni et al., 2014, Muha and Müller, 2013, Mudiganti et al., 2010, Yan et al., 2010, Edwards et al., 2009, Krejcí et al., 2009, Bornemann et al., 2008, Harbison and Sehgal, 2008, Lujan et al., 2008, Mensch et al., 2008, Morozova et al., 2007, Sambandan et al., 2006, Jordan et al., 2005, Torroja et al., 2005, Strigini and Cohen, 2000, Lin et al., 1997)

suppenkasper

(Wilson, 2004, Princivalle and de Agostini, 2002, Cumberledge and Reichsman, 1997, Haerry et al., 1997, Haerry et al., 1997)

Secondary FlyBase IDs

FBgn0010851
FBgn0002456
FBgn0010929
FBgn0015500
FBgn0086381

Datasets (8)

Study focus (0)

Experimental Role

Project

Project Type

Title

Study result (8)

Result

Result Type

Title

scRNAseq_2020_Cattenoz_NI_seq_clustering

cell clustering analysis

Clustering analysis of hemocytes from non-infested third instar larvae

scRNAseq_2020_Cattenoz_WI_seq_clustering

cell clustering analysis

Clustering analysis of hemocytes from wasp-infested third instar larvae

scRNAseq_2020_Cho_NI72LG_seq_clustering

cell clustering analysis

Clustering analysis of lymph gland cells from non-infested larvae at 72 h after egg-laying

scRNAseq_2020_Cho_NI96LG_seq_clustering

cell clustering analysis

Clustering analysis of lymph gland cells from non-infested larvae at 96 h after egg-laying

scRNAseq_2020_Cho_NI120LG_seq_clustering

cell clustering analysis

Clustering analysis of lymph gland cells from non-infested larvae at 120 h after egg-laying

scRNAseq_2020_Cho_WI96LG_seq_clustering

cell clustering analysis

Clustering analysis of lymph gland cells from wasp-infested larvae at 96 h after egg-laying

scRNAseq_2020_Cho_NI96HL_seq_clustering

cell clustering analysis

Clustering analysis of circulating hemocytes from non-infested larvae at 96 h after egg-laying

scRNAseq_2020_Cho_NI120HL_seq_clustering

cell clustering analysis

Clustering analysis of circulating hemocytes from non-infested larvae at 120 h after egg-laying

References (164)

The following external sites may use different assemblies or annotations than FlyBase.

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