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Gene Dmel\hpo

General Information
Symbol	Dmel\hpo	Species	D. melanogaster
Name	hippo	Annotation symbol	CG11228
Feature type	protein_coding_gene	FlyBase ID	FBgn0261456
Gene Model Status	Current	Stock availability	8 publicly available
Also Known As	dMST
Genomic Location
Chromosome (arm)	2R	Recombination map
Cytogenetic map	56D13-56D13	Sequence location	2R:15,381,501..15,384,361 [-]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents Beta	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene hippo is referred to in FlyBase by the symbol Dmel\hpo (CG11228, FBgn0261456). It is a protein_coding_gene from Drosophila melanogaster. There is experimental evidence that it has the molecular function: protein binding; protein serine/threonine kinase activity; protein homodimerization activity; kinase activity. There is experimental evidence for 16 unique biological process terms, many of which group under: biological regulation; regulation of apoptotic process; single-organism developmental process; cell proliferation; sensory organ development; programmed cell death; cell death; macromolecule modification; response to ionizing radiation; growth. 64 alleles are reported. The phenotypes of these alleles are annotated with: organ system subdivision; external compound sense organ; imaginal precursor; adult segment; thoracic segment; organ system; adult; peripheral nervous system; embryonic/larval imaginal precursor; pigment cell. It has 2 annotated transcripts and 2 annotated polypeptides. Protein features are: Mst1 SARAH domain; Protein kinase, ATP binding site; Protein kinase, catalytic domain; Protein kinase-like domain; SARAH domain; Serine/threonine- / dual specificity protein kinase, catalytic domain. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of moderate expression. Peak expression observed within 00-12 hour embryonic stages. Summary of FlyAtlas Anatomical Expression Data: Nearly all larval and adult tissues/organs expressed at moderate levels. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, larval/adult central nervous system, adult crop, larval midgut, larval/adult hindgut, larval/adult Malpighian tubules, adult heart, larval/adult fat body, larval/adult salivary gland, larval trachea, adult female reproductive system, adult male accessory gland, larval/adult carcass. Comments on Affy2 ProbeSet: ProbeSet 1634303_at partially aligns to an exonic region of the only FlyBase-annotated transcript isoform of hpo: 6 out of 14 probes fall into this exonic region. Gene sequence location is 2R:15381501..15384361.
User Contributed Data
	Beta version, feedback welcome
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 56D13-56D13   Limits computationally determined from genome sequence between P{lacW}l(2)k00705k00705&P{lacW}mei-W68k05603 and P{EP}CG11007EP736
Experimentally Determined Cytological Location
Cytogenetic map Notes References
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\hpo for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
	Gene model reviewed during 5.45
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) hpo-RA FBtr0086500  NM_137583   2503   669 hpo-RB FBtr0331920  NM_001274163   2804   669
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein hpo-PA   FBpp0085688   75.1   669   4.95     NP_611427   AAF57543 hpo-PB   FBpp0304253   75.1   669   4.95     NP_001261092   AGB93624
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Protein kinase, catalytic domain (IPR000719) Serine/threonine- / dual specificity protein kinase, catalytic domain (IPR002290) Protein kinase-like domain (IPR011009) SARAH domain (IPR011524) Protein kinase, ATP binding site (IPR017441) Mst1 SARAH domain (IPR024205)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA263901   AA391266   AA391329   AA392706   AA392854   AA438795   AA735171   AE013599 AAF57543   AE013599 AGB93624   AI113866   AI512446   AW940359   AY069088 AAL39233   BF498073   BI163872   BI166415   BI168237   BI172686   BI214689   BI215068   BI215222   BI215924   BI228480   BI241991   BI358004   BI358199   BI366561   BI367968   BI368674   BI368735   BI371955   BI373555   BI486465   BI617921   BI641047   BI641608   CO190412   CO268038   CO269305   CO281358   CO281683   CO301637   CO313386   CO314429   CO318669   CO323505   CO323564   CO329665   CO343246   EC051017   EC053519   EC054010   EC054017   EC056450   EC060121   EC060711   EC065224   EC073596   EC074636   EC077806   EC082450   EC089843   EC200673   EC204839   EC208624   EC210828   EC211362   EC213517   EC222375   EC227341   EC236682   EC244813   EC245305   EC245487   GH739325   GH739696   GH739919   GH740016   GH740574   GH741114   GH741736   GH742366   GH742589   GH742888   GH742965   GH743534   GH743545   GH743936   GH744456   GH744477   GH744553   GH744554   GH744555   GH744602   GH745031   GH745328   GH745333   GH745375   GH745477   GH745529   GH745851   GH746041   GH746118   GH746171   GH746191   GH746192   GH746279   GH746454   GH746550   GH746679   GH746980   GH747109   GH747161   GH747228   GH747240   GH761415   GH761536   GH761835   GH761851   GH761882   GH762232   GH762291   GH762544   GH762597   GH762982   GH763038   GH763607   GH764141   GH764347   GH764417   GH764572   GH765008   GH765608   GH765818   GH766228   GH766348   GH766548   GH766659   GH766786   GH766811   GH766936   GH767092   GH767216   GH767771   GH767838   GH767850   GH768135   GH768218   GH768617   GH768683   GH768860   GH769227   GH769515   GH769835
UniProtKB/Swiss-Prot	Q8T0S6
UniProtKB/TrEMBL
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
in situ Stage Tissue/Position (including subcellular localization) Reference embryonic stage 1 -- 3   organism   (Fisher et al., 2012) Comment:maternally deposited embryonic stage 4 -- 6   organism | faint & ubiquitous   (Fisher et al., 2012) embryonic stage 7 -- 8   organism | faint & ubiquitous   (Fisher et al., 2012) organism | ubiquitous   (Fisher et al., 2012) embryonic stage 9 -- 10   organism | faint & ubiquitous   (Fisher et al., 2012) organism | ubiquitous   (Fisher et al., 2012) third instar larval stage   imaginal disc   (Harvey et al., 2003)
Additional Descriptive Data
	hpo transcript was detected in all imaginal discs with unpatterned expression. (Harvey et al., 2003)
Marker for
Subcellular Localization
CV Term
Polypeptide Expression
Additional Descriptive Data
Marker for
Subcellular Localization (GO Cellular Component)
CV term Evidence References
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools
Reference	See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes.
FlyAtlas Anatomy Microarray
FlyAtlas Anatomical Expression Data (FlyAtlas-RNA.adult) (FlyAtlas-RNA.larva)    Styles Linear Logarithmic Heatmap Back-to-back    Scales gene max expression Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Nearly all larval and adult tissues/organs expressed at moderate levels. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, larval/adult central nervous system, adult crop, larval midgut, larval/adult hindgut, larval/adult Malpighian tubules, adult heart, larval/adult fat body, larval/adult salivary gland, larval trachea, adult female reproductive system, adult male accessory gland, larval/adult carcass. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (>999.999) Linear, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    366.25 Larval Midgut    113.2 Larval Hindgut    350.1 Larval Malpighian Tubules    459.5 Larval Fat Body    395.5 Larval Salivary Gland    332.5 Larval Trachea    314.95 Larval Carcass    338 Adult Head    141.7 Adult Eye    90.825 Adult Brain    164.2 Adult Thoracic-Abdominal Ganglion    192 Adult Crop    204.5 Adult Midgut    80.6 Adult Hindgut    151.4 Adult Malpighian Tubules    120.8 Adult Fat Body    206.7 Adult Salivary Gland    184.6 Adult Heart    218.125 Adult VirginFemale Spermatheca    315.4 Adult InseminatedFemale Spermatheca    308.9 Adult Ovary    424.8 Adult Testis    69.1 Adult Male Accessory Gland    116.9 Adult Carcass    114.1 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    366.25 Larval Midgut    113.2 Larval Hindgut    350.1 Larval Malpighian Tubules    459.5 Larval Fat Body    395.5 Larval Salivary Gland    332.5 Larval Trachea    314.95 Larval Carcass    338 Adult Head    141.7 Adult Eye    90.825 Adult Brain    164.2 Adult Thoracic-Abdominal Ganglion    192 Adult Crop    204.5 Adult Midgut    80.6 Adult Hindgut    151.4 Adult Malpighian Tubules    120.8 Adult Fat Body    206.7 Adult Salivary Gland    184.6 Adult Heart    218.125 Adult VirginFemale Spermatheca    315.4 Adult InseminatedFemale Spermatheca    308.9 Adult Ovary    424.8 Adult Testis    69.1 Adult Male Accessory Gland    116.9 Adult Carcass    114.1 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    366.25 Larval Midgut    113.2 Larval Hindgut    350.1 Larval Malpighian Tubules    459.5 Larval Fat Body    395.5 Larval Salivary Gland    332.5 Larval Trachea    314.95 Larval Carcass    338 Adult Head    141.7 Adult Eye    90.825 Adult Brain    164.2 Adult Thoracic-Abdominal Ganglion    192 Adult Crop    204.5 Adult Midgut    80.6 Adult Hindgut    151.4 Adult Malpighian Tubules    120.8 Adult Fat Body    206.7 Adult Salivary Gland    184.6 Adult Heart    218.125 Adult VirginFemale Spermatheca    315.4 Adult InseminatedFemale Spermatheca    308.9 Adult Ovary    424.8 Adult Testis    69.1 Adult Male Accessory Gland    116.9 Adult Carcass    114.1 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    366.25 Larval Midgut    113.2 Larval Hindgut    350.1 Larval Malpighian Tubules    459.5 Larval Fat Body    395.5 Larval Salivary Gland    332.5 Larval Trachea    314.95 Larval Carcass    338 Adult Head    141.7 Adult Eye    90.825 Adult Brain    164.2 Adult Thoracic-Abdominal Ganglion    192 Adult Crop    204.5 Adult Midgut    80.6 Adult Hindgut    151.4 Adult Malpighian Tubules    120.8 Adult Fat Body    206.7 Adult Salivary Gland    184.6 Adult Heart    218.125 Adult VirginFemale Spermatheca    315.4 Adult InseminatedFemale Spermatheca    308.9 Adult Ovary    424.8 Adult Testis    69.1 Adult Male Accessory Gland    116.9 Adult Carcass    114.1 Expression Level Scale  Very high  log, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    366.25 Larval Midgut    113.2 Larval Hindgut    350.1 Larval Malpighian Tubules    459.5 Larval Fat Body    395.5 Larval Salivary Gland    332.5 Larval Trachea    314.95 Larval Carcass    338 Adult Head    141.7 Adult Eye    90.825 Adult Brain    164.2 Adult Thoracic-Abdominal Ganglion    192 Adult Crop    204.5 Adult Midgut    80.6 Adult Hindgut    151.4 Adult Malpighian Tubules    120.8 Adult Fat Body    206.7 Adult Salivary Gland    184.6 Adult Heart    218.125 Adult VirginFemale Spermatheca    315.4 Adult InseminatedFemale Spermatheca    308.9 Adult Ovary    424.8 Adult Testis    69.1 Adult Male Accessory Gland    116.9 Adult Carcass    114.1 Expression Level Scale  None   Low   Moderate   High  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    366.25 Larval Midgut    113.2 Larval Hindgut    350.1 Larval Malpighian Tubules    459.5 Larval Fat Body    395.5 Larval Salivary Gland    332.5 Larval Trachea    314.95 Larval Carcass    338 Adult Head    141.7 Adult Eye    90.825 Adult Brain    164.2 Adult Thoracic-Abdominal Ganglion    192 Adult Crop    204.5 Adult Midgut    80.6 Adult Hindgut    151.4 Adult Malpighian Tubules    120.8 Adult Fat Body    206.7 Adult Salivary Gland    184.6 Adult Heart    218.125 Adult VirginFemale Spermatheca    315.4 Adult InseminatedFemale Spermatheca    308.9 Adult Ovary    424.8 Adult Testis    69.1 Adult Male Accessory Gland    116.9 Adult Carcass    114.1 Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    366.25 Larval Midgut    113.2 Larval Hindgut    350.1 Larval Malpighian Tubules    459.5 Larval Fat Body    395.5 Larval Salivary Gland    332.5 Larval Trachea    314.95 Larval Carcass    338 Adult Head    141.7 Adult Eye    90.825 Adult Brain    164.2 Adult Thoracic-Abdominal Ganglion    192 Adult Crop    204.5 Adult Midgut    80.6 Adult Hindgut    151.4 Adult Malpighian Tubules    120.8 Adult Fat Body    206.7 Adult Salivary Gland    184.6 Adult Heart    218.125 Adult VirginFemale Spermatheca    315.4 Adult InseminatedFemale Spermatheca    308.9 Adult Ovary    424.8 Adult Testis    69.1 Adult Male Accessory Gland    116.9 Adult Carcass    114.1 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    366.25 Larval Midgut    113.2 Larval Hindgut    350.1 Larval Malpighian Tubules    459.5 Larval Fat Body    395.5 Larval Salivary Gland    332.5 Larval Trachea    314.95 Larval Carcass    338 Adult Head    141.7 Adult Eye    90.825 Adult Brain    164.2 Adult Thoracic-Abdominal Ganglion    192 Adult Crop    204.5 Adult Midgut    80.6 Adult Hindgut    151.4 Adult Malpighian Tubules    120.8 Adult Fat Body    206.7 Adult Salivary Gland    184.6 Adult Heart    218.125 Adult VirginFemale Spermatheca    315.4 Adult InseminatedFemale Spermatheca    308.9 Adult Ovary    424.8 Adult Testis    69.1 Adult Male Accessory Gland    116.9 Adult Carcass    114.1 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    141.7   NA  Eye    90.825   NA  Brain    164.2   366.25  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    192   NA  Crop    204.5   113.2  Midgut    80.6   350.1  Hindgut    151.4   459.5  Malpighian Tubules    120.8   395.5  Fat Body    206.7   332.5  Salivary Gland    184.6   NA  Heart    218.125   314.95  Trachea    NA   NA  VirginFemale Spermatheca    315.4   NA  InseminatedFemale Spermatheca    308.9   NA  Ovary    424.8   NA  Testis    69.1   NA  Male Accessory Gland    116.9   338  Carcass    114.1 FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
modENCODE Anatomy RNA-Seq
modENCODE Tissue Expression Data (modENCODE_mRNA-Seq_tissues)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    16 central nervous system, larvae L3    22 central nervous system, pupae P8    9 head, virgin 1-day female    6 head, virgin 4-day female    5 head, virgin 20-day female    5 head, mated 1-day female    6 head, mated 4-day female    5 head, mated 20-day female    5 head, mated 1-day male    7 head, mated 4-day male    7 head, mated 20-day male    9 salivary gland, larvae L3 wandering    7 salivary gland, white prepupae    34 digestive system, larvae L3 wandering    11 digestive system, 1-day adult    3 digestive system, 4-day adult    4 digestive system, 20-day adult    4 fat body, larvae L3 wandering    4 fat body, white prepupae    14 fat body, pupae P8    6 carcass, larvae L3 wandering    20 carcass, 1-day adult    5 carcass, 4-day adult    5 carcass, 20-day adult    5 ovary, virgin 4-day female    28 ovary, mated 4-day female    25 testis, mated 4-day male    7 accessory gland, mated 4-day male    4 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering    16 central nervous system, larvae L3    22 central nervous system, pupae P8    9 head, virgin 1-day female    6 head, virgin 4-day female    5 head, virgin 20-day female    5 head, mated 1-day female    6 head, mated 4-day female    5 head, mated 20-day female    5 head, mated 1-day male    7 head, mated 4-day male    7 head, mated 20-day male    9 salivary gland, larvae L3 wandering    7 salivary gland, white prepupae  (34) digestive system, larvae L3 wandering    11 digestive system, 1-day adult    3 digestive system, 4-day adult    4 digestive system, 20-day adult    4 fat body, larvae L3 wandering    4 fat body, white prepupae    14 fat body, pupae P8    6 carcass, larvae L3 wandering    20 carcass, 1-day adult    5 carcass, 4-day adult    5 carcass, 20-day adult    5 ovary, virgin 4-day female  (28) ovary, mated 4-day female    25 testis, mated 4-day male    7 accessory gland, mated 4-day male    4 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    16 central nervous system, larvae L3    22 central nervous system, pupae P8    9 head, virgin 1-day female    6 head, virgin 4-day female    5 head, virgin 20-day female    5 head, mated 1-day female    6 head, mated 4-day female    5 head, mated 20-day female    5 head, mated 1-day male    7 head, mated 4-day male    7 head, mated 20-day male    9 salivary gland, larvae L3 wandering    7 salivary gland, white prepupae    34 digestive system, larvae L3 wandering    11 digestive system, 1-day adult    3 digestive system, 4-day adult    4 digestive system, 20-day adult    4 fat body, larvae L3 wandering    4 fat body, white prepupae    14 fat body, pupae P8    6 carcass, larvae L3 wandering    20 carcass, 1-day adult    5 carcass, 4-day adult    5 carcass, 20-day adult    5 ovary, virgin 4-day female    28 ovary, mated 4-day female    25 testis, mated 4-day male    7 accessory gland, mated 4-day male    4 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    16 central nervous system, larvae L3    22 central nervous system, pupae P8    9 head, virgin 1-day female    6 head, virgin 4-day female    5 head, virgin 20-day female    5 head, mated 1-day female    6 head, mated 4-day female    5 head, mated 20-day female    5 head, mated 1-day male    7 head, mated 4-day male    7 head, mated 20-day male    9 salivary gland, larvae L3 wandering    7 salivary gland, white prepupae    34 digestive system, larvae L3 wandering    11 digestive system, 1-day adult    3 digestive system, 4-day adult    4 digestive system, 20-day adult    4 fat body, larvae L3 wandering    4 fat body, white prepupae    14 fat body, pupae P8    6 carcass, larvae L3 wandering    20 carcass, 1-day adult    5 carcass, 4-day adult    5 carcass, 20-day adult    5 ovary, virgin 4-day female    28 ovary, mated 4-day female    25 testis, mated 4-day male    7 accessory gland, mated 4-day male    4 Expression Level Scale  Extremely high  log, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    16 central nervous system, larvae L3    22 central nervous system, pupae P8    9 head, virgin 1-day female    6 head, virgin 4-day female    5 head, virgin 20-day female    5 head, mated 1-day female    6 head, mated 4-day female    5 head, mated 20-day female    5 head, mated 1-day male    7 head, mated 4-day male    7 head, mated 20-day male    9 salivary gland, larvae L3 wandering    7 salivary gland, white prepupae    34 digestive system, larvae L3 wandering    11 digestive system, 1-day adult    3 digestive system, 4-day adult    4 digestive system, 20-day adult    4 fat body, larvae L3 wandering    4 fat body, white prepupae    14 fat body, pupae P8    6 carcass, larvae L3 wandering    20 carcass, 1-day adult    5 carcass, 4-day adult    5 carcass, 20-day adult    5 ovary, virgin 4-day female    28 ovary, mated 4-day female    25 testis, mated 4-day male    7 accessory gland, mated 4-day male    4 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering    16 central nervous system, larvae L3    22 central nervous system, pupae P8    9 head, virgin 1-day female    6 head, virgin 4-day female    5 head, virgin 20-day female    5 head, mated 1-day female    6 head, mated 4-day female    5 head, mated 20-day female    5 head, mated 1-day male    7 head, mated 4-day male    7 head, mated 20-day male    9 salivary gland, larvae L3 wandering    7 salivary gland, white prepupae  (34) digestive system, larvae L3 wandering    11 digestive system, 1-day adult    3 digestive system, 4-day adult    4 digestive system, 20-day adult    4 fat body, larvae L3 wandering    4 fat body, white prepupae    14 fat body, pupae P8    6 carcass, larvae L3 wandering    20 carcass, 1-day adult    5 carcass, 4-day adult    5 carcass, 20-day adult    5 ovary, virgin 4-day female  28 ovary, mated 4-day female    25 testis, mated 4-day male    7 accessory gland, mated 4-day male    4 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    16 central nervous system, larvae L3    22 central nervous system, pupae P8    9 head, virgin 1-day female    6 head, virgin 4-day female    5 head, virgin 20-day female    5 head, mated 1-day female    6 head, mated 4-day female    5 head, mated 20-day female    5 head, mated 1-day male    7 head, mated 4-day male    7 head, mated 20-day male    9 salivary gland, larvae L3 wandering    7 salivary gland, white prepupae    34 digestive system, larvae L3 wandering    11 digestive system, 1-day adult    3 digestive system, 4-day adult    4 digestive system, 20-day adult    4 fat body, larvae L3 wandering    4 fat body, white prepupae    14 fat body, pupae P8    6 carcass, larvae L3 wandering    20 carcass, 1-day adult    5 carcass, 4-day adult    5 carcass, 20-day adult    5 ovary, virgin 4-day female    28 ovary, mated 4-day female    25 testis, mated 4-day male    7 accessory gland, mated 4-day male    4 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    16 central nervous system, larvae L3    22 central nervous system, pupae P8    9 head, virgin 1-day female    6 head, virgin 4-day female    5 head, virgin 20-day female    5 head, mated 1-day female    6 head, mated 4-day female    5 head, mated 20-day female    5 head, mated 1-day male    7 head, mated 4-day male    7 head, mated 20-day male    9 salivary gland, larvae L3 wandering    7 salivary gland, white prepupae    34 digestive system, larvae L3 wandering    11 digestive system, 1-day adult    3 digestive system, 4-day adult    4 digestive system, 20-day adult    4 fat body, larvae L3 wandering    4 fat body, white prepupae    14 fat body, pupae P8    6 carcass, larvae L3 wandering    20 carcass, 1-day adult    5 carcass, 4-day adult    5 carcass, 20-day adult    5 ovary, virgin 4-day female    28 ovary, mated 4-day female    25 testis, mated 4-day male    7 accessory gland, mated 4-day male    4 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Tissue   Expression Level imaginal disc, larvae L3 wandering     central nervous system, larvae L3     central nervous system, pupae P8     head, virgin 1-day female     head, virgin 4-day female     head, virgin 20-day female     head, mated 1-day female     head, mated 4-day female     head, mated 20-day female     head, mated 1-day male     head, mated 4-day male     head, mated 20-day male     salivary gland, larvae L3 wandering     salivary gland, white prepupae     digestive system, larvae L3 wandering     digestive system, 1-day adult     digestive system, 4-day adult     digestive system, 20-day adult     fat body, larvae L3 wandering     fat body, white prepupae     fat body, pupae P8     carcass, larvae L3 wandering     carcass, 1-day adult     carcass, 4-day adult     carcass, 20-day adult     ovary, virgin 4-day female     ovary, mated 4-day female     testis, mated 4-day male     accessory gland, mated 4-day male
modENCODE Development RNA-Seq
modENCODE Temporal Expression Data (modENCODE_mRNA-Seq_U)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of moderate expression. Peak expression observed within 00-12 hour embryonic stages. [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    54 embryo 02-04hr    94 embryo 04-06hr    94 embryo 06-08hr    63 embryo 08-10hr    55 embryo 10-12hr    59 embryo 12-14hr    34 embryo 14-16hr    26 embryo 16-18hr    21 embryo 18-20hr    13 embryo 20-22hr    31 embryo 22-24hr    24 larva L1    10 larva L2    9 larva L3 12hr old    11 larva L3 puffstage 1-2    12 larva L3 puffstage 3-6    22 larva L3 puffstage 7-9    31 white prepupae new    40 white prepupae 12hr    39 white prepupae 24hr    32 pupae 2d postWPP    17 pupae 3d postWPP    10 pupae 4d postWPP    8 adult male 01day    10 adult male 05day    9 adult male 30day    7 adult female 01day    20 adult female 05day    31 adult female 30day    30 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (54) embryo 02-04hr  (94) embryo 04-06hr  (94) embryo 06-08hr  (63) embryo 08-10hr  (55) embryo 10-12hr  (59) embryo 12-14hr  (34) embryo 14-16hr  26 embryo 16-18hr    21 embryo 18-20hr    13 embryo 20-22hr  (31) embryo 22-24hr    24 larva L1    10 larva L2    9 larva L3 12hr old    11 larva L3 puffstage 1-2    12 larva L3 puffstage 3-6    22 larva L3 puffstage 7-9  (31) white prepupae new  (40) white prepupae 12hr  (39) white prepupae 24hr  (32) pupae 2d postWPP    17 pupae 3d postWPP    10 pupae 4d postWPP    8 adult male 01day    10 adult male 05day    9 adult male 30day    7 adult female 01day    20 adult female 05day  (31) adult female 30day  (30) Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    54 embryo 02-04hr    94 embryo 04-06hr    94 embryo 06-08hr    63 embryo 08-10hr    55 embryo 10-12hr    59 embryo 12-14hr    34 embryo 14-16hr    26 embryo 16-18hr    21 embryo 18-20hr    13 embryo 20-22hr    31 embryo 22-24hr    24 larva L1    10 larva L2    9 larva L3 12hr old    11 larva L3 puffstage 1-2    12 larva L3 puffstage 3-6    22 larva L3 puffstage 7-9    31 white prepupae new    40 white prepupae 12hr    39 white prepupae 24hr    32 pupae 2d postWPP    17 pupae 3d postWPP    10 pupae 4d postWPP    8 adult male 01day    10 adult male 05day    9 adult male 30day    7 adult female 01day    20 adult female 05day    31 adult female 30day    30 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    54 embryo 02-04hr    94 embryo 04-06hr    94 embryo 06-08hr    63 embryo 08-10hr    55 embryo 10-12hr    59 embryo 12-14hr    34 embryo 14-16hr    26 embryo 16-18hr    21 embryo 18-20hr    13 embryo 20-22hr    31 embryo 22-24hr    24 larva L1    10 larva L2    9 larva L3 12hr old    11 larva L3 puffstage 1-2    12 larva L3 puffstage 3-6    22 larva L3 puffstage 7-9    31 white prepupae new    40 white prepupae 12hr    39 white prepupae 24hr    32 pupae 2d postWPP    17 pupae 3d postWPP    10 pupae 4d postWPP    8 adult male 01day    10 adult male 05day    9 adult male 30day    7 adult female 01day    20 adult female 05day    31 adult female 30day    30 Expression Level Scale  Extremely high  log, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    54 embryo 02-04hr    94 embryo 04-06hr    94 embryo 06-08hr    63 embryo 08-10hr    55 embryo 10-12hr    59 embryo 12-14hr    34 embryo 14-16hr    26 embryo 16-18hr    21 embryo 18-20hr    13 embryo 20-22hr    31 embryo 22-24hr    24 larva L1    10 larva L2    9 larva L3 12hr old    11 larva L3 puffstage 1-2    12 larva L3 puffstage 3-6    22 larva L3 puffstage 7-9    31 white prepupae new    40 white prepupae 12hr    39 white prepupae 24hr    32 pupae 2d postWPP    17 pupae 3d postWPP    10 pupae 4d postWPP    8 adult male 01day    10 adult male 05day    9 adult male 30day    7 adult female 01day    20 adult female 05day    31 adult female 30day    30 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (54) embryo 02-04hr  (94) embryo 04-06hr  (94) embryo 06-08hr  (63) embryo 08-10hr  (55) embryo 10-12hr  (59) embryo 12-14hr  (34) embryo 14-16hr  26 embryo 16-18hr    21 embryo 18-20hr    13 embryo 20-22hr  31 embryo 22-24hr    24 larva L1    10 larva L2    9 larva L3 12hr old    11 larva L3 puffstage 1-2    12 larva L3 puffstage 3-6    22 larva L3 puffstage 7-9  31 white prepupae new  (40) white prepupae 12hr  (39) white prepupae 24hr  32 pupae 2d postWPP    17 pupae 3d postWPP    10 pupae 4d postWPP    8 adult male 01day    10 adult male 05day    9 adult male 30day    7 adult female 01day    20 adult female 05day  31 adult female 30day  30 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    54 embryo 02-04hr    94 embryo 04-06hr    94 embryo 06-08hr    63 embryo 08-10hr    55 embryo 10-12hr    59 embryo 12-14hr    34 embryo 14-16hr    26 embryo 16-18hr    21 embryo 18-20hr    13 embryo 20-22hr    31 embryo 22-24hr    24 larva L1    10 larva L2    9 larva L3 12hr old    11 larva L3 puffstage 1-2    12 larva L3 puffstage 3-6    22 larva L3 puffstage 7-9    31 white prepupae new    40 white prepupae 12hr    39 white prepupae 24hr    32 pupae 2d postWPP    17 pupae 3d postWPP    10 pupae 4d postWPP    8 adult male 01day    10 adult male 05day    9 adult male 30day    7 adult female 01day    20 adult female 05day    31 adult female 30day    30 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    54 embryo 02-04hr    94 embryo 04-06hr    94 embryo 06-08hr    63 embryo 08-10hr    55 embryo 10-12hr    59 embryo 12-14hr    34 embryo 14-16hr    26 embryo 16-18hr    21 embryo 18-20hr    13 embryo 20-22hr    31 embryo 22-24hr    24 larva L1    10 larva L2    9 larva L3 12hr old    11 larva L3 puffstage 1-2    12 larva L3 puffstage 3-6    22 larva L3 puffstage 7-9    31 white prepupae new    40 white prepupae 12hr    39 white prepupae 24hr    32 pupae 2d postWPP    17 pupae 3d postWPP    10 pupae 4d postWPP    8 adult male 01day    10 adult male 05day    9 adult male 30day    7 adult female 01day    20 adult female 05day    31 adult female 30day    30 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     modENCODE Temporal Expression Data (Graveley et al., 2011)
modENCODE Cell Lines RNA-Seq
modENCODE Cell Line Expression Data (modENCODE_mRNA-Seq_cell.A) (modENCODE_mRNA-Seq_cell.B)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    29 Schneider line 2 Sg4    30 embryonic 1182-4H    13 embryonic GM2    18 embryonic Kc167    13 embryonic S1    22 embryonic S3    21 leg disc CME L1    26 wing disc CME-W2    20 wing disc ML-DmD8    25 wing disc ML-DmD9    21 wing disc ML-DmD16-c3    19 wing disc ML-DmD21    29 wing disc ML-DmD32    14 haltere disc ML-DmD17-c3    25 eye-antennal disc ML-DmD11    24 antennal disc ML-DmD20-c5    29 mixed discs ML-DmD4-c1    31 CNS ML-DmBG1-c1    22 CNS ML-DmBG2-c2    14 tumorous blood cells mbn2    28 ovary fGS/OSS    28 ovary OSC    17 ovary OSS    8 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+  (29) Schneider line 2 Sg4  (30) embryonic 1182-4H    13 embryonic GM2    18 embryonic Kc167    13 embryonic S1    22 embryonic S3    21 leg disc CME L1  26 wing disc CME-W2    20 wing disc ML-DmD8    25 wing disc ML-DmD9    21 wing disc ML-DmD16-c3    19 wing disc ML-DmD21  (29) wing disc ML-DmD32    14 haltere disc ML-DmD17-c3    25 eye-antennal disc ML-DmD11    24 antennal disc ML-DmD20-c5  (29) mixed discs ML-DmD4-c1  (31) CNS ML-DmBG1-c1    22 CNS ML-DmBG2-c2    14 tumorous blood cells mbn2  (28) ovary fGS/OSS  (28) ovary OSC    17 ovary OSS    8 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    29 Schneider line 2 Sg4    30 embryonic 1182-4H    13 embryonic GM2    18 embryonic Kc167    13 embryonic S1    22 embryonic S3    21 leg disc CME L1    26 wing disc CME-W2    20 wing disc ML-DmD8    25 wing disc ML-DmD9    21 wing disc ML-DmD16-c3    19 wing disc ML-DmD21    29 wing disc ML-DmD32    14 haltere disc ML-DmD17-c3    25 eye-antennal disc ML-DmD11    24 antennal disc ML-DmD20-c5    29 mixed discs ML-DmD4-c1    31 CNS ML-DmBG1-c1    22 CNS ML-DmBG2-c2    14 tumorous blood cells mbn2    28 ovary fGS/OSS    28 ovary OSC    17 ovary OSS    8 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    29 Schneider line 2 Sg4    30 embryonic 1182-4H    13 embryonic GM2    18 embryonic Kc167    13 embryonic S1    22 embryonic S3    21 leg disc CME L1    26 wing disc CME-W2    20 wing disc ML-DmD8    25 wing disc ML-DmD9    21 wing disc ML-DmD16-c3    19 wing disc ML-DmD21    29 wing disc ML-DmD32    14 haltere disc ML-DmD17-c3    25 eye-antennal disc ML-DmD11    24 antennal disc ML-DmD20-c5    29 mixed discs ML-DmD4-c1    31 CNS ML-DmBG1-c1    22 CNS ML-DmBG2-c2    14 tumorous blood cells mbn2    28 ovary fGS/OSS    28 ovary OSC    17 ovary OSS    8 Expression Level Scale  Extremely high  log, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    29 Schneider line 2 Sg4    30 embryonic 1182-4H    13 embryonic GM2    18 embryonic Kc167    13 embryonic S1    22 embryonic S3    21 leg disc CME L1    26 wing disc CME-W2    20 wing disc ML-DmD8    25 wing disc ML-DmD9    21 wing disc ML-DmD16-c3    19 wing disc ML-DmD21    29 wing disc ML-DmD32    14 haltere disc ML-DmD17-c3    25 eye-antennal disc ML-DmD11    24 antennal disc ML-DmD20-c5    29 mixed discs ML-DmD4-c1    31 CNS ML-DmBG1-c1    22 CNS ML-DmBG2-c2    14 tumorous blood cells mbn2    28 ovary fGS/OSS    28 ovary OSC    17 ovary OSS    8 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+  29 Schneider line 2 Sg4  30 embryonic 1182-4H    13 embryonic GM2    18 embryonic Kc167    13 embryonic S1    22 embryonic S3    21 leg disc CME L1  26 wing disc CME-W2    20 wing disc ML-DmD8    25 wing disc ML-DmD9    21 wing disc ML-DmD16-c3    19 wing disc ML-DmD21  29 wing disc ML-DmD32    14 haltere disc ML-DmD17-c3    25 eye-antennal disc ML-DmD11    24 antennal disc ML-DmD20-c5  29 mixed discs ML-DmD4-c1  31 CNS ML-DmBG1-c1    22 CNS ML-DmBG2-c2    14 tumorous blood cells mbn2  28 ovary fGS/OSS  28 ovary OSC    17 ovary OSS    8 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    29 Schneider line 2 Sg4    30 embryonic 1182-4H    13 embryonic GM2    18 embryonic Kc167    13 embryonic S1    22 embryonic S3    21 leg disc CME L1    26 wing disc CME-W2    20 wing disc ML-DmD8    25 wing disc ML-DmD9    21 wing disc ML-DmD16-c3    19 wing disc ML-DmD21    29 wing disc ML-DmD32    14 haltere disc ML-DmD17-c3    25 eye-antennal disc ML-DmD11    24 antennal disc ML-DmD20-c5    29 mixed discs ML-DmD4-c1    31 CNS ML-DmBG1-c1    22 CNS ML-DmBG2-c2    14 tumorous blood cells mbn2    28 ovary fGS/OSS    28 ovary OSC    17 ovary OSS    8 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    29 Schneider line 2 Sg4    30 embryonic 1182-4H    13 embryonic GM2    18 embryonic Kc167    13 embryonic S1    22 embryonic S3    21 leg disc CME L1    26 wing disc CME-W2    20 wing disc ML-DmD8    25 wing disc ML-DmD9    21 wing disc ML-DmD16-c3    19 wing disc ML-DmD21    29 wing disc ML-DmD32    14 haltere disc ML-DmD17-c3    25 eye-antennal disc ML-DmD11    24 antennal disc ML-DmD20-c5    29 mixed discs ML-DmD4-c1    31 CNS ML-DmBG1-c1    22 CNS ML-DmBG2-c2    14 tumorous blood cells mbn2    28 ovary fGS/OSS    28 ovary OSC    17 ovary OSS    8 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Cell Line   Expression Level Schneider line 2 S2R+     Schneider line 2 Sg4     embryonic 1182-4H     embryonic GM2     embryonic Kc167     embryonic S1     embryonic S3     leg disc CME L1     wing disc CME-W2     wing disc ML-DmD8     wing disc ML-DmD9     wing disc ML-DmD16-c3     wing disc ML-DmD21     wing disc ML-DmD32     haltere disc ML-DmD17-c3     eye-antennal disc ML-DmD11     antennal disc ML-DmD20-c5     mixed discs ML-DmD4-c1     CNS ML-DmBG1-c1     CNS ML-DmBG2-c2     tumorous blood cells mbn2     ovary fGS/OSS     ovary OSC     ovary OSS
modENCODE Treatments RNA-Seq
modENCODE Treatment Expression Data (modENCODE_mRNA-Seq_treatments)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    11 cold shock, 4-day adult    9 heat shock, 4-day adult    12 Cadmium 50 mM 6 hrs, larvae L3    9 Cadmium 50 mM 12 hrs, larvae L3    14 Cadmium 50 mM 48 hrs, 4-day adult    12 Cadmium 100 mM 48 hrs, 4-day adult    16 Copper 0.5 mM 12 hrs, larvae L3    10 Copper 15 mM 48 hrs, 4-day adult    11 Zinc 5 mM 12 hrs, larvae L3    7 Zinc 4.5 mM 48 hrs, 4-day adult    6 Ethanol 2.5% 3 hrs, larvae L3    19 Ethanol 5% 3 hrs, larvae L3    8 Ethanol 10% 3 hrs, larvae L3    7 Caffeine 1.5 mg/ml 4 hrs, larvae L3    9 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    17 Caffeine 25 mg/ml 48 hrs, 4-day adult    11 Paraquat 5 mM 48 hrs, 4-day adult    13 Paraquat 10 mM 48 hrs, 4-day adult    14 Rotenone 2 μg 12 hrs, larvae L3    9 Rotenone 8 μg 12 hrs, larvae L3    9 Expression Level Scale  Very low   Low   Moderate  Linear, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult    11 cold shock, 4-day adult    9 heat shock, 4-day adult    12 Cadmium 50 mM 6 hrs, larvae L3    9 Cadmium 50 mM 12 hrs, larvae L3    14 Cadmium 50 mM 48 hrs, 4-day adult    12 Cadmium 100 mM 48 hrs, 4-day adult    16 Copper 0.5 mM 12 hrs, larvae L3    10 Copper 15 mM 48 hrs, 4-day adult    11 Zinc 5 mM 12 hrs, larvae L3    7 Zinc 4.5 mM 48 hrs, 4-day adult    6 Ethanol 2.5% 3 hrs, larvae L3    19 Ethanol 5% 3 hrs, larvae L3    8 Ethanol 10% 3 hrs, larvae L3    7 Caffeine 1.5 mg/ml 4 hrs, larvae L3    9 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    17 Caffeine 25 mg/ml 48 hrs, 4-day adult    11 Paraquat 5 mM 48 hrs, 4-day adult    13 Paraquat 10 mM 48 hrs, 4-day adult    14 Rotenone 2 μg 12 hrs, larvae L3    9 Rotenone 8 μg 12 hrs, larvae L3    9 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    11 cold shock, 4-day adult    9 heat shock, 4-day adult    12 Cadmium 50 mM 6 hrs, larvae L3    9 Cadmium 50 mM 12 hrs, larvae L3    14 Cadmium 50 mM 48 hrs, 4-day adult    12 Cadmium 100 mM 48 hrs, 4-day adult    16 Copper 0.5 mM 12 hrs, larvae L3    10 Copper 15 mM 48 hrs, 4-day adult    11 Zinc 5 mM 12 hrs, larvae L3    7 Zinc 4.5 mM 48 hrs, 4-day adult    6 Ethanol 2.5% 3 hrs, larvae L3    19 Ethanol 5% 3 hrs, larvae L3    8 Ethanol 10% 3 hrs, larvae L3    7 Caffeine 1.5 mg/ml 4 hrs, larvae L3    9 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    17 Caffeine 25 mg/ml 48 hrs, 4-day adult    11 Paraquat 5 mM 48 hrs, 4-day adult    13 Paraquat 10 mM 48 hrs, 4-day adult    14 Rotenone 2 μg 12 hrs, larvae L3    9 Rotenone 8 μg 12 hrs, larvae L3    9 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    11 cold shock, 4-day adult    9 heat shock, 4-day adult    12 Cadmium 50 mM 6 hrs, larvae L3    9 Cadmium 50 mM 12 hrs, larvae L3    14 Cadmium 50 mM 48 hrs, 4-day adult    12 Cadmium 100 mM 48 hrs, 4-day adult    16 Copper 0.5 mM 12 hrs, larvae L3    10 Copper 15 mM 48 hrs, 4-day adult    11 Zinc 5 mM 12 hrs, larvae L3    7 Zinc 4.5 mM 48 hrs, 4-day adult    6 Ethanol 2.5% 3 hrs, larvae L3    19 Ethanol 5% 3 hrs, larvae L3    8 Ethanol 10% 3 hrs, larvae L3    7 Caffeine 1.5 mg/ml 4 hrs, larvae L3    9 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    17 Caffeine 25 mg/ml 48 hrs, 4-day adult    11 Paraquat 5 mM 48 hrs, 4-day adult    13 Paraquat 10 mM 48 hrs, 4-day adult    14 Rotenone 2 μg 12 hrs, larvae L3    9 Rotenone 8 μg 12 hrs, larvae L3    9 Expression Level Scale  Extremely high  log, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    11 cold shock, 4-day adult    9 heat shock, 4-day adult    12 Cadmium 50 mM 6 hrs, larvae L3    9 Cadmium 50 mM 12 hrs, larvae L3    14 Cadmium 50 mM 48 hrs, 4-day adult    12 Cadmium 100 mM 48 hrs, 4-day adult    16 Copper 0.5 mM 12 hrs, larvae L3    10 Copper 15 mM 48 hrs, 4-day adult    11 Zinc 5 mM 12 hrs, larvae L3    7 Zinc 4.5 mM 48 hrs, 4-day adult    6 Ethanol 2.5% 3 hrs, larvae L3    19 Ethanol 5% 3 hrs, larvae L3    8 Ethanol 10% 3 hrs, larvae L3    7 Caffeine 1.5 mg/ml 4 hrs, larvae L3    9 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    17 Caffeine 25 mg/ml 48 hrs, 4-day adult    11 Paraquat 5 mM 48 hrs, 4-day adult    13 Paraquat 10 mM 48 hrs, 4-day adult    14 Rotenone 2 μg 12 hrs, larvae L3    9 Rotenone 8 μg 12 hrs, larvae L3    9 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult    11 cold shock, 4-day adult    9 heat shock, 4-day adult    12 Cadmium 50 mM 6 hrs, larvae L3    9 Cadmium 50 mM 12 hrs, larvae L3    14 Cadmium 50 mM 48 hrs, 4-day adult    12 Cadmium 100 mM 48 hrs, 4-day adult    16 Copper 0.5 mM 12 hrs, larvae L3    10 Copper 15 mM 48 hrs, 4-day adult    11 Zinc 5 mM 12 hrs, larvae L3    7 Zinc 4.5 mM 48 hrs, 4-day adult    6 Ethanol 2.5% 3 hrs, larvae L3    19 Ethanol 5% 3 hrs, larvae L3    8 Ethanol 10% 3 hrs, larvae L3    7 Caffeine 1.5 mg/ml 4 hrs, larvae L3    9 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    17 Caffeine 25 mg/ml 48 hrs, 4-day adult    11 Paraquat 5 mM 48 hrs, 4-day adult    13 Paraquat 10 mM 48 hrs, 4-day adult    14 Rotenone 2 μg 12 hrs, larvae L3    9 Rotenone 8 μg 12 hrs, larvae L3    9 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    11 cold shock, 4-day adult    9 heat shock, 4-day adult    12 Cadmium 50 mM 6 hrs, larvae L3    9 Cadmium 50 mM 12 hrs, larvae L3    14 Cadmium 50 mM 48 hrs, 4-day adult    12 Cadmium 100 mM 48 hrs, 4-day adult    16 Copper 0.5 mM 12 hrs, larvae L3    10 Copper 15 mM 48 hrs, 4-day adult    11 Zinc 5 mM 12 hrs, larvae L3    7 Zinc 4.5 mM 48 hrs, 4-day adult    6 Ethanol 2.5% 3 hrs, larvae L3    19 Ethanol 5% 3 hrs, larvae L3    8 Ethanol 10% 3 hrs, larvae L3    7 Caffeine 1.5 mg/ml 4 hrs, larvae L3    9 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    17 Caffeine 25 mg/ml 48 hrs, 4-day adult    11 Paraquat 5 mM 48 hrs, 4-day adult    13 Paraquat 10 mM 48 hrs, 4-day adult    14 Rotenone 2 μg 12 hrs, larvae L3    9 Rotenone 8 μg 12 hrs, larvae L3    9 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    11 cold shock, 4-day adult    9 heat shock, 4-day adult    12 Cadmium 50 mM 6 hrs, larvae L3    9 Cadmium 50 mM 12 hrs, larvae L3    14 Cadmium 50 mM 48 hrs, 4-day adult    12 Cadmium 100 mM 48 hrs, 4-day adult    16 Copper 0.5 mM 12 hrs, larvae L3    10 Copper 15 mM 48 hrs, 4-day adult    11 Zinc 5 mM 12 hrs, larvae L3    7 Zinc 4.5 mM 48 hrs, 4-day adult    6 Ethanol 2.5% 3 hrs, larvae L3    19 Ethanol 5% 3 hrs, larvae L3    8 Ethanol 10% 3 hrs, larvae L3    7 Caffeine 1.5 mg/ml 4 hrs, larvae L3    9 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    17 Caffeine 25 mg/ml 48 hrs, 4-day adult    11 Paraquat 5 mM 48 hrs, 4-day adult    13 Paraquat 10 mM 48 hrs, 4-day adult    14 Rotenone 2 μg 12 hrs, larvae L3    9 Rotenone 8 μg 12 hrs, larvae L3    9 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Treatment   Expression Level extended cold, 4-day adult     cold shock, 4-day adult     heat shock, 4-day adult     Cadmium 50 mM 6 hrs, larvae L3     Cadmium 50 mM 12 hrs, larvae L3     Cadmium 50 mM 48 hrs, 4-day adult     Cadmium 100 mM 48 hrs, 4-day adult     Copper 0.5 mM 12 hrs, larvae L3     Copper 15 mM 48 hrs, 4-day adult     Zinc 5 mM 12 hrs, larvae L3     Zinc 4.5 mM 48 hrs, 4-day adult     Ethanol 2.5% 3 hrs, larvae L3     Ethanol 5% 3 hrs, larvae L3     Ethanol 10% 3 hrs, larvae L3     Caffeine 1.5 mg/ml 4 hrs, larvae L3     Caffeine 2.5 mg/ml 48 hrs, 4-day adult     Caffeine 25 mg/ml 48 hrs, 4-day adult     Paraquat 5 mM 48 hrs, 4-day adult     Paraquat 10 mM 48 hrs, 4-day adult     Rotenone 2 μg 12 hrs, larvae L3     Rotenone 8 μg 12 hrs, larvae L3
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (Graveley et al., 2011) mE1_20_mRNA_expression_cluster_03
External Data & Images
Linkouts	BDGP expression data • GH10354 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0261456
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele lethal, with Scer\GAL4GMR.PF hpoScer\UAS.cWa lethal | first instar larval stage hpoKC202 hpoKC221 hpoKS240 lethal | larval stage | recessive hpoBF33 hpoJM1 lethal | pupal stage, with Scer\GAL4GMR.PU hpoScer\UAS.WT.T:Zzzz\FLAG lethal | recessive hpo42-20 hpo42-47 hpo42-48 partially lethal - majority die | pupal stage | somatic clone hpo42-47 hpo42-48 viable, with Scer\GAL4pnr-MD237 hpoGD1570 Sterility Allele fertile, with Scer\GAL4nos.UTR.T:Hsim\VP16 hpoScer\UAS.cUa Other Phenotypes Allele cell death defective | somatic clone hpoKC202 cell growth defective hpoKC203 hpoKC221 hpoKS240 cell growth defective | somatic clone hpoKC202 decreased cell death | pupal stage | somatic clone hpo42-47 decreased cell death | somatic clone hpoBF33 hpoMGH1 hpoMGH3 decreased cell death | somatic clone, with Scer\GAL4Act5C.PP hpodsRNA.Scer\UAS decreased cell number | somatic clone, with Scer\GAL4Act5C.PP hpoScer\UAS.cPa developmental rate defective | pharate adult stage, with Scer\GAL4GMR.PF hpoScer\UAS.cUa hyperplasia | somatic clone hpo42-47 increased cell death, with Scer\GAL4C5 hpoScer\UAS.cUa increased cell death, with Scer\GAL4GMR.PF hpoN.Scer\UAS.T:Zzzz\FLAG hpoScer\UAS.cPa hpoScer\UAS.cUa increased cell death, with Scer\GAL4hs.PB hpoScer\UAS.cUa increased cell death, with Scer\GAL4nub-AC-62 hpoΔauto.Scer\UAS increased cell number | cell non-autonomous | somatic clone hpoBF33 increased cell number | somatic clone hpoBF33 hpoMGH1 hpoMGH3 increased cell number | somatic clone, with Scer\GAL4Act5C.PP hpodsRNA.Scer\UAS increased cell number | third instar larval stage, with Scer\GAL4repo.PU hpoKK101704 mitotic cell cycle defective hpoKC202 mitotic cell cycle defective | cell non-autonomous | somatic clone hpoBF33 mitotic cell cycle defective | somatic clone hpoBF33 hpoMGH1 hpoMGH3 mitotic cell cycle defective | somatic clone, with Scer\GAL4Act5C.PP hpodsRNA.Scer\UAS hpoScer\UAS.cPa neuroanatomy defective hpoMGH4 size defective | adult stage hpoGMR.PW size defective | adult stage, with Scer\GAL4en-e16E hpodsRNA.Scer\UAS stress response defective | somatic clone hpo42-47 tumorigenic | somatic clone hpoBF33 visible hpoGMR.PW visible, with Scer\GAL4Bx-MS1096 hpoI634D.Scer\UAS.T:Zzzz\FLAG hpoK71R.Scer\UAS hpoM242E.Scer\UAS.T:Zzzz\FLAG hpoScer\UAS.WT.T:Zzzz\FLAG hpoT189A.Scer\UAS.T:Zzzz\FLAG hpoT189E.Scer\UAS.T:Zzzz\FLAG hpoT195A.Scer\UAS.T:Zzzz\FLAG hpoT195A-Δ.Scer\UAS.T:Zzzz\FLAG hpoT195E.Scer\UAS.T:Zzzz\FLAG hpoT195E-Δ.Scer\UAS.T:Zzzz\FLAG hpoΔ238-246.Scer\UAS.T:Zzzz\FLAG visible, with Scer\GAL4GMR.PF hpoN.Scer\UAS.T:Zzzz\FLAG hpoScer\UAS.cUa visible, with Scer\GAL4nub-AC-62 hpoScer\UAS.cUa visible, with Scer\GAL4pnr-MD237 hpoGD1570 visible | adult stage hpoGMR.PW visible | adult stage, with Scer\GAL4en-e16E hpodsRNA.Scer\UAS visible | recessive hpo42-47 hpoKC202 visible | somatic clone hpo42-47 hpoBF33 hpoMGH1 hpounspecified Phenotype manifest in Allele adult cuticle | somatic clone hpo42-47 adult external head | somatic clone hpo42-47 hpo42-20 adult head, with Scer\GAL4C5 hpoScer\UAS.cUa adult head | somatic clone hpo42-48 hpo42-47 dorsal multidendritic neuron ddaC | somatic clone hpoMGH4 embryonic/larval brain | third instar larval stage, with Scer\GAL4repo.PU hpoKK101704 embryonic/larval glial cell | third instar larval stage, with Scer\GAL4repo.PU hpoKK101704 eye hpoKS240 hpoKC221 hpo42-47 hpoKC203 hpoKC202 hpoGMR.PW eye, with Scer\GAL4GMR.PF hpoScer\UAS.cUa hpoN.Scer\UAS.T:Zzzz\FLAG eye | P-stage | somatic clone hpo42-47 eye | pupal stage | somatic clone, with Scer\GAL4αTub84B.PL hpodsRNA.Scer\UAS eye | somatic clone hpo42-47 hpoMGH1 hpo42-20 hpoBF33 hpounspecified eye | temperature conditional, with Scer\GAL4GMR.PF hpoScer\UAS.cUa eye-antennal disc, with Scer\GAL4Act5C.PP hpoScer\UAS.cPa hpodsRNA.Scer\UAS eye-antennal disc, with Scer\GAL4GMR.PF hpoScer\UAS.cPa eye disc, with Scer\GAL4GMR.PF hpoScer\UAS.cUa eye disc | posterior | somatic clone hpo42-47 eye disc | third instar larval stage, with Scer\GAL4GMR.PF hpoScer\UAS.cUa eye disc | third instar larval stage, with Scer\GAL4repo.PU hpoKK101704 haltere hpoKC202 haltere, with Scer\GAL4Act5C.PP hpodsRNA.Scer\UAS head & cuticle hpoKS240 hpoKC221 hpoKC203 hpoKC202 imaginal disc, with Scer\GAL4Act5C.PP hpodsRNA.Scer\UAS interommatidial bristle, with Scer\GAL4GMR.PF hpoScer\UAS.cUa interommatidial bristle | somatic clone hpoMGH1 interommatidial bristle | somatic clone | supernumerary hpoBF33 inter-ommatidial cell | pupal stage, with Scer\GAL4GMR.PF hpoScer\UAS.cUa inter-ommatidial cell | pupal stage | supernumerary hpo42-47 intestinal stem cell | somatic clone hpoBF33 leg hpoKC202 mesothoracic tergum, with Scer\GAL4pnr-MD237 hpoGD1570 ommatidium hpoGMR.PW ommatidium, with Scer\GAL4GMR.PF hpoScer\UAS.cUa ommatidium | somatic clone hpo42-47 hpoMGH1 hpo42-20 photoreceptor cell hpoKC202 photoreceptor cell, with Scer\GAL4GMR.PF hpoScer\UAS.cUa photoreceptor cell R8 of pale ommatidium | supernumerary hpoKC203 photoreceptor cell R8 of pale ommatidium | supernumerary, with Scer\GAL4GMR.long hpoK71R.Scer\UAS photoreceptor cell R8 of yellow ommatidium hpoKC203 photoreceptor cell R8 of yellow ommatidium, with Scer\GAL4GMR.long hpoK71R.Scer\UAS pigment cell, with Scer\GAL4GMR.PF hpoScer\UAS.cUa pigment cell | ectopic | somatic clone hpo42-47 retina, with Scer\GAL4GMR.PF hpoScer\UAS.cUa retina | P-stage | somatic clone hpoMGH3 hpoMGH1 thorax hpoKC202 wing hpoKC202 wing, with Scer\GAL4Bx-MS1096 hpoK71R.Scer\UAS hpoScer\UAS.cWa hpo318-669.Scer\UAS hpoScer\UAS.WT.T:Zzzz\FLAG hpoI634D.Scer\UAS.T:Zzzz\FLAG hpoT189A.Scer\UAS.T:Zzzz\FLAG hpoT195A.Scer\UAS.T:Zzzz\FLAG hpoM242E.Scer\UAS.T:Zzzz\FLAG hpoT195E.Scer\UAS.T:Zzzz\FLAG hpoT189E.Scer\UAS.T:Zzzz\FLAG hpoΔ238-246.Scer\UAS.T:Zzzz\FLAG hpoT195E-Δ.Scer\UAS.T:Zzzz\FLAG hpoT195A-Δ.Scer\UAS.T:Zzzz\FLAG wing, with Scer\GAL4C5 hpoScer\UAS.cUa wing, with Scer\GAL4nub-AC-62 hpoScer\UAS.cUa wing | posterior, with Scer\GAL4en-e16E hpodsRNA.Scer\UAS wing disc, with Scer\GAL4hs.PB hpoScer\UAS.cUa wing disc, with Scer\GAL4nub-AC-62 hpoΔauto.Scer\UAS wing disc | larval stage | somatic clone hpo42-47 wing disc | somatic clone, with Scer\GAL4Act5C.PI hpoScer\UAS.T:Zzzz\FLAG wing disc | somatic clone, with Scer\GAL4unspecified hpoScer\UAS.cPa wing hinge primordium, with Scer\GAL4sd-SG29.1 hpodsRNA.Scer\UAS
Classical Alleles ( 20 )
For All Classical Alleles Show
Allele of hpo Class Mutagen Stocks Known lesion hpoG3315 P-element activity 1 Yes hpoKC202 loss of function allele FLPase ethyl methanesulfonate 1 Yes hpoKS240 loss of function allele FLPase ethyl methanesulfonate 1 Yes hpo3D 0 Yes hpo40-47 0 -- hpo42-20 hypomorphic allele - genetic evidence X ray 0 Yes hpo42-47 loss of function allele X ray 0 Yes hpo42-48 X ray 0 Yes hpo5.1 P-element activity 0 Yes hpoBF33 loss of function allele ethyl methanesulfonate 0 Yes hpoJM1 ethyl methanesulfonate 0 Yes hpoJM4 ethyl methanesulfonate 0 -- hpoKC203 loss of function allele FLPase ethyl methanesulfonate 0 Yes hpoKC221 loss of function allele FLPase ethyl methanesulfonate 0 Yes hpoMGH1 ethyl methanesulfonate 0 Yes hpoMGH2 ethyl methanesulfonate 0 Yes hpoMGH3 ethyl methanesulfonate 0 Yes hpoMGH4 loss of function allele 0 -- hpoT195A.Act5C.T:Hsap\MYC 0 Yes hpounspecified 0 --
Alleles Carried on Transgenic Constructs ( 44 )
For All Alleles Carried on Transgenic Constructs Show
Allele of hpo Class Mutagen Stocks Known lesion hpoGD1570 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes hpoGL00046 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes hpoHMS00006 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes hpoJF02740 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes hpoKK101704 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes hpo+t4.0 in vitro construct - genomic fragment 0 Yes hpo318-669.Scer\UAS in vitro construct - deletion 0 Yes hpoAct5C.cCa.T:Hsap\MYC in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes hpoAct5C.T:Avic\GFP in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes hpoAct5C.T:Hsap\MYC in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes hpoAct5C.T:Zzzz\FLAG in vitro construct - coding region fusion in vitro construct - regulatory fusion 0 Yes hpoC.Scer\UAS.T:Zzzz\FLAG in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes hpodsRNA.0.7 in vitro construct - RNAi 0 Yes hpodsRNA.cCa in vitro construct - RNAi 0 Yes hpodsRNA.cHa in vitro construct - RNAi 0 Yes hpodsRNA.Scer\UAS in vitro construct - RNAi 0 Yes hpoGMR.PH in vitro construct - regulatory fusion 0 Yes hpoGMR.PW in vitro construct - regulatory fusion 0 Yes hpoI634D.Scer\UAS.T:Zzzz\FLAG in vitro construct - regulatory fusion in vitro construct - coding region fusion in vitro construct - amino acid replacement 0 Yes hpoK71R.Act5C.T:Hsap\MYC in vitro construct - site directed mutagenesis 0 Yes hpoK71R.Act5C.T:Zzzz\FLAG in vitro construct - regulatory fusion in vitro construct - site directed mutagenesis in vitro construct - coding region fusion 0 Yes hpoK71R.Scer\UAS.cUa in vitro construct - site directed mutagenesis in vitro construct - regulatory fusion 0 Yes hpoK71R.Scer\UAS in vitro construct - site directed mutagenesis 0 Yes hpoM242E.Scer\UAS.T:Zzzz\FLAG in vitro construct - regulatory fusion in vitro construct - coding region fusion in vitro construct - amino acid replacement 0 Yes hpoN.KR.Scer\UAS.T:Zzzz\FLAG in vitro construct - site directed mutagenesis 0 Yes hpoN.Scer\UAS.T:Zzzz\FLAG in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes hpoNES1-2.Scer\UAS.T:Zzzz\FLAG in vitro construct - regulatory fusion in vitro construct - coding region fusion in vitro construct - amino acid replacement 0 Yes hpoScer\UAS.cEa in vitro construct - regulatory fusion 0 Yes hpoScer\UAS.cHa in vitro construct - regulatory fusion 0 Yes hpoScer\UAS.cPa in vitro construct - regulatory fusion 0 Yes hpoScer\UAS.cUa in vitro construct - regulatory fusion 0 Yes hpoScer\UAS.cWa in vitro construct - regulatory fusion 0 Yes hpoScer\UAS.T:Zzzz\FLAG in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes hpoScer\UAS.WT.T:Zzzz\FLAG in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes hpoT189A.Scer\UAS.T:Zzzz\FLAG in vitro construct - regulatory fusion in vitro construct - coding region fusion in vitro construct - amino acid replacement 0 Yes hpoT189E.Scer\UAS.T:Zzzz\FLAG in vitro construct - regulatory fusion in vitro construct - coding region fusion in vitro construct - amino acid replacement 0 Yes hpoT195A-Δ.Scer\UAS.T:Zzzz\FLAG in vitro construct - regulatory fusion in vitro construct - coding region fusion in vitro construct - deletion in vitro construct - amino acid replacement 0 Yes hpoT195A.Scer\UAS.T:Zzzz\FLAG in vitro construct - regulatory fusion in vitro construct - coding region fusion in vitro construct - amino acid replacement 0 Yes hpoT195E-Δ.Scer\UAS.T:Zzzz\FLAG in vitro construct - regulatory fusion in vitro construct - coding region fusion in vitro construct - deletion in vitro construct - amino acid replacement 0 Yes hpoT195E.Scer\UAS.T:Zzzz\FLAG in vitro construct - regulatory fusion in vitro construct - coding region fusion in vitro construct - amino acid replacement 0 Yes hpoαTub84B.T:Zzzz\FLAG in vitro construct - regulatory fusion 0 Yes hpoΔ238-246.Scer\UAS.T:Zzzz\FLAG in vitro construct - regulatory fusion in vitro construct - coding region fusion in vitro construct - deletion 0 Yes hpoΔauto.Scer\UAS in vitro construct - deletion in vitro construct - regulatory fusion 0 Yes hpoΔC.Act5C.T:Zzzz\FLAG in vitro construct - deletion in vitro construct - coding region fusion in vitro construct - regulatory fusion 0 Yes
Aneuploid Aberrations
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD1570} NA P{KK101704} NA P{TRiP.GL00046} NA P{TRiP.HMS00006} NA P{TRiP.JF02740} NA P{UAS-dMST.C.FLAG} NA P{UAS-dMST.FLAG} NA P{UAS-dMST.N.FLAG} NA P{UAS-dMST.N.KR.FLAG} NA P{UAS-hpo.318-669} NA P{UAS-hpo.E} NA P{UAS-hpo.I634D.FLAG} NA P{UAS-hpo.K71R.U} NA P{UAS-hpo.K71R} NA P{UAS-hpo.M242E.FLAG} NA P{UAS-hpo.NES1-2.FLAG} NA P{UAS-hpo.P} NA P{UAS-hpo.T189A.FLAG} NA P{UAS-hpo.T189E.FLAG} NA P{UAS-hpo.T195A.FLAG} NA P{UAS-hpo.T195A-Δ.FLAG} NA P{UAS-hpo.T195E.FLAG} NA P{UAS-hpo.T195E-Δ.FLAG} NA P{UAS-hpo.U} NA P{UAS-hpo.W} NA P{UAS-hpo.WT.FLAG} NA P{UAS-hpo.Δ238-246.FLAG} NA P{UAS-hpo.Δauto} NA P{UAS-RNAi-hpo.P} NA characterization construct P{GMR-hpo.H} NA P{GMR-hpo.W} NA P{hpo.t4.0} NA P{tub-dMST.FLAG} NA
Insertions
	Type of insertions Name Expression data insertion of mobile activating element P{EP}hpoG3315 NA
Gene Ontology: Function, Process & Cellular Component ( 23 unique terms )
	There is no information supporting a cellular component term for this gene. (Based on a review of available data on: 2006-10-26)
Terms Based on Experimental Evidence ( 20 terms )
Molecular Function
CV term Evidence References
kinase activity inferred from direct assay (Colombani et al., 2006) protein binding inferred from physical interaction with ex (Yu et al., 2010) inferred from physical interaction with Rassf (Polesello et al., 2006) inferred from physical interaction with sav (Polesello et al., 2006) protein homodimerization activity inferred from direct assay (Jin et al., 2012) protein serine/threonine kinase activity inferred from direct assay (assigned by UniProtKB) (Wu et al., 2003)
Biological Process
CV term Evidence References
apoptotic process inferred from mutant phenotype (assigned by UniProtKB) (Wu et al., 2003) cell proliferation inferred from mutant phenotype (Jia et al., 2004) inferred from mutant phenotype (assigned by UniProtKB) (Wu et al., 2003) eye development inferred from mutant phenotype (Nolo et al., 2006) induction of apoptosis inferred from mutant phenotype (Udan et al., 2003, Nolo et al., 2006) intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator inferred from genetic interaction with p53 (Colombani et al., 2006) morphogenesis of an epithelial sheet inferred from mutant phenotype (Thompson and Cohen, 2006) negative regulation of apoptotic process inferred from mutant phenotype (Jia et al., 2004) negative regulation of cell proliferation inferred from mutant phenotype (Udan et al., 2003) negative regulation of glial cell proliferation inferred from mutant phenotype (Reddy and Irvine, 2011) negative regulation of neuron apoptotic process inferred from mutant phenotype (Herz et al., 2006) organ growth inferred from direct assay (Verghese et al., 2012) protein phosphorylation inferred from direct assay (assigned by UniProtKB) (Wu et al., 2003) R8 cell fate specification inferred from mutant phenotype (Mikeladze-Dvali et al., 2005) regulation of cell proliferation inferred from mutant phenotype (Nolo et al., 2006) response to ionizing radiation inferred from mutant phenotype (Colombani et al., 2006) stem cell proliferation inferred from direct assay (Ren et al., 2010)
Cellular Component ( 0 terms)
Terms Based on Predictions or Assertions ( 4 terms )
Molecular Function
CV term Evidence References
ATP binding inferred from electronic annotation with InterPro:IPR000719, InterPro:IPR002290, InterPro:IPR017441 (FlyBase Curators et al., 2004-) receptor signaling protein serine/threonine kinase activity inferred from sequence or structural similarity with EMBL:U28726 (FlyBase, 1992-) non-traceable author statement (Morrison et al., 2000)
Biological Process
CV term Evidence References
negative regulation of organ growth traceable author statement (Hafen and Stocker, 2003) protein phosphorylation non-traceable author statement (Morrison et al., 2000)
Cellular Component ( 0 terms)
Sequence Ontology: Class of Gene
	gene   nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
protein-protein
Interacting group Assay References
hpo - Aats-lys anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) hpo - CG10158 anti tag coimmunoprecipitation, anti tag western blot, peptide massfingerprinting (Ribeiro et al., 2010) hpo - CG10306 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) hpo - CG10887 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) hpo - CG11526 anti tag coimmunoprecipitation, peptide massfingerprinting (Ribeiro et al., 2010) hpo - CG17494 anti tag coimmunoprecipitation, peptide massfingerprinting, experimental knowledge based (Mintseris et al., 2009.11.23, Guruharsha et al., 2011) hpo - CG1785 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) hpo - CG3817 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) hpo - CG7414 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) hpo - Cka anti tag coimmunoprecipitation, anti tag western blot, peptide massfingerprinting (Ribeiro et al., 2010) hpo - Csl4 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) hpo - Mer anti tag coimmunoprecipitation, anti tag western blot (Reddy and Irvine, 2011) hpo - Mob4 anti tag coimmunoprecipitation, peptide massfingerprinting (Ribeiro et al., 2010) hpo - Patr-1 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) hpo - Pp1-87B anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) hpo - Pp2A-29B anti tag coimmunoprecipitation, peptide massfingerprinting (Ribeiro et al., 2010) hpo - Rassf anti tag coimmunoprecipitation, peptide massfingerprinting, anti tag western blot (Ribeiro et al., 2010) hpo - RpS11 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) hpo - Tao protein kinase assay, anti tag western blot (Boggiano et al., 2011) hpo - Top1 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) hpo - alt anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) hpo - eIF3-S8 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) hpo - ex anti tag coimmunoprecipitation, anti tag western blot (Reddy and Irvine, 2011) hpo - l(2)03709 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) hpo - mts anti tag coimmunoprecipitation, peptide massfingerprinting (Ribeiro et al., 2010) hpo - sav anti tag coimmunoprecipitation, peptide massfingerprinting, anti tag western blot (Ribeiro et al., 2010, Reddy and Irvine, 2011)
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions hpo allele Gene References hpo42-20 wts (Wu et al., 2003) hpodsRNA.Scer\UAS W (Pantalacci et al., 2003) hpoGMR.PW wts (Wu et al., 2003) hpoMGH1 grim (Harvey et al., 2003) hpoN.Scer\UAS.T:Zzzz\FLAG wts (Jia et al., 2003) unspecified ban (Nolo et al., 2006) p53 (Colombani et al., 2006) Rassf (Polesello et al., 2006) Uba1 (Pfleger et al., 2007)
External Data
Linkouts	DPiM - DPiM, Drosophila Protein interaction Map • FBgn0261456 DroID - A comprehensive database of gene and protein interactions. • FBgn0261456 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 37247 SignaLink - A protein-protein and protein-miRNA interaction database with multi-layered structure and multiple confidence scores. • Q8T0S6
Orthologs
OrthoDB Orthologs (67) - based on analysis using Dmel annotation version 5.41
OrthoDB Ortholog Groups
	OrthoDB orthology group searches (Waterhouse et al., 2011, Nucleic Acids Res. 39(Database issue): D283--D288) Drosophila inclusive ortholog search EOG64J33N Dipteran inclusive ortholog search EOG6F4SKD Insect inclusive ortholog search EOG69P8TN Arthropod inclusive ortholog search EOG6CZ8X2 Metazoa inclusive ortholog search EOG664C55
Orthologs in Drosophila Species (EOG64J33N)
Organism Common Name Gene AAA Syntenic Ortholog Multiple Dmel Genes in this Orthologous Group Drosophila melanogaster fruit fly  Dmel\hpo     Drosophila simulans   Dsim\GD25317 Y   Drosophila sechellia   Dsec\GM19825 Y   Drosophila erecta   Dere\GG20903 Y   Drosophila yakuba   Dyak\GE13841 Y   Drosophila ananassae   Dana\GF13179 Y   Drosophila pseudoobscura pseudoobscura   Dpse\GA10852 Y   Drosophila persimilis   Dper\GL10521 Y   Drosophila willistoni   Dwil\GK15703 Y   Drosophila virilis   Dvir\GJ21419 Y   Drosophila mojavensis   Dmoj\GI20569 Y   Drosophila grimshawi   Dgri\GH22772 Y
Orthologs in non-Drosophila Dipterans (EOG6F4SKD)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Aedes aegypti Yellow fever mosquito  Aaeg\AAEL006539   Anopheles gambiae Malaria mosquito  Agam\AGAP006044   Culex quinquefasciatus Southern house mosquito  Cqui\CPIJ000288
Orthologs in non-Dipteran Insects (EOG69P8TN)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Apis mellifera Western honey bee  Amel\GB51064   Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG011381   Acromyrmex echinatior Panamanian leafcutter ant  Aech\AECH11897   Atta cephalotes Leafcutter ant  Acep\ACEP23592   Camponotus floridanus Florida carpenter ant  Cflo\CFLO14123   Harpegnathos saltator Jerdons jumping ant  Hsal\HSAL17385   Linepithema humile Argentine ant  Lhum\LH21463   Pogonomyrmex barbatus Red harvester ant  Pbar\PB16804   Solenopsis invicta Red fire ant  Sinv\SINV21391   Acyrthosiphon pisum Pea aphid  Apim\ACYPI009258   Acyrthosiphon pisum Pea aphid  Apim\ACYPI006337   Bombyx mori Silkmoth  Bmor\BGIBMGA013478   Pediculus humanus Human body louse  Phum\PHUM617080   Tribolium castaneum Red flour beetle  Tcas\TC004606
Orthologs in non-Insect Arthropods (EOG6CZ8X2)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Daphnia pulex Water flea  Dpux\wsp   Ixodes scapularis Deer tick  Isca\ISCW021388
Orthologs in non-Arthropod Metazoa (EOG664C55)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Caenorhabditis elegans Nematode  Cele\cst-2 Y Caenorhabditis elegans Nematode  Cele\F14H12.4 Y Caenorhabditis elegans Nematode  Cele\T19A5.2 Y Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_003403gn Y Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_018724gn Y Danio rerio Zebrafish  Drer\stk24b Y Danio rerio Zebrafish  Drer\zgc:175288 Y Danio rerio Zebrafish  Drer\stk25 Y Danio rerio Zebrafish  Drer\stk24a Y Danio rerio Zebrafish  Drer\stk3 Y Danio rerio Zebrafish  Drer\stk25a Y Xenopus tropicalis Western clawed frog  Xtro\stk25 Y Xenopus tropicalis Western clawed frog  Xtro\mst4 Y Xenopus tropicalis Western clawed frog  Xtro\stk3 Y Xenopus tropicalis Western clawed frog  Xtro\stk24 Y Xenopus tropicalis Western clawed frog  Xtro\stk4 Y Gallus gallus Domestic chicken  Ggal\MST4 Y Gallus gallus Domestic chicken  Ggal\STK4 Y Gallus gallus Domestic chicken  Ggal\STK24 Y Gallus gallus Domestic chicken  Ggal\STK25 Y Gallus gallus Domestic chicken  Ggal\LOC425375 Y Mus musculus House mouse  Mmus\Stk25 Y Mus musculus House mouse  Mmus\2610018G03Rik Y Mus musculus House mouse  Mmus\Stk3 Y Mus musculus House mouse  Mmus\Stk4 Y Mus musculus House mouse  Mmus\Stk24 Y Rattus norvegicus Norway rat  Rnor\Stk3 Y Rattus norvegicus Norway rat  Rnor\ENSRNOG00000011511 Y Rattus norvegicus Norway rat  Rnor\Stk25 Y Rattus norvegicus Norway rat  Rnor\Stk4 Y Rattus norvegicus Norway rat  Rnor\Mst4 Y Homo sapiens Human  Hsap\STK24 Y Homo sapiens Human  Hsap\MST4 Y Homo sapiens Human  Hsap\STK3 Y Homo sapiens Human  Hsap\STK4 Y Homo sapiens Human  Hsap\STK25 Y
Human Orthologs (5)
Gene OMIM HGNC Hsap\STK24     Hsap\MST4     Hsap\STK3     Hsap\STK4     Hsap\STK25
AAA Orthologs (11) based on analysis using Dmel annotation version 4.3
Organism Gene Drosophila simulans Dsim\GD25317 Drosophila sechellia Dsec\GM19825 Drosophila erecta Dere\GG20903 Drosophila yakuba Dyak\GE13841 Drosophila ananassae Dana\GF13179 Drosophila pseudoobscura pseudoobscura Dpse\GA10852 Drosophila persimilis Dper\GL10521 Drosophila willistoni Dwil\GK15703 Drosophila virilis Dvir\GJ21419 Drosophila mojavensis Dmoj\GI20569 Drosophila grimshawi Dgri\GH22772
Stocks & Reagents
Stocks Listed in FlyBase ( 8 )
Bloomington	27661 y1 v1; P{TRiP.JF02740}attP2 33614 y1 v1; P{TRiP.HMS00006}attP2 27105 y1 w*; P{EP}hpoG3315 35176 y1 sc* v1; P{TRiP.GL00046}attP2 25085 P{hsFLP}22, y1 w*; P{neoFRT}42D hpoKS240/CyO 25090 yd2 w1118 P{ey-FLP.N}2; P{neoFRT}42D hpoKC202/CyO, P{GAL4-Kr.C}DC3, P{UAS-GFP.S65T}DC7
VDRC	v104169 P{KK101704}VIE-260B v7823 w1118; P{GD1570}v7823
Genomic Clones ( 2 )
	BACR25K02 BACR26L01 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 150 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	GH10354
Other clones	DPiM_GH10354
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	AT12433 LD01524 LD07131 LD09864 LD10481 LD11810 LD11983 LD13151 LD44326 RE03391 RE06534 RE08831 RE15331 RE20687 RE21269 RE21564 RE22701 RE26033 RE39204 RE44651 RE44888 RE52129 RE53856 RE54681 RE54754 RE58983 RE60875 RE69892 RH48402 SD24134 SD25031
Other clones	20761 34679 42540 43126 43298 45507 45745 54872 63847 64026 100570 100762 106809 158142 174257 190781 CK01.118B.D1 CK01.123C.H2 CK01.170A.E8 EC051017 EC053519 EC054010 EC054017 EC056450 EK048103 EK090013 EK094061 EK156944 EK157963 EK181754 EK190631 EK190842 EK232464 EK236163 EK273401 EK293349 EP16403 RP01180 RP001001523 RP001002889 RP001003181 RP001003892 RP001004699 RP001004769 RP001004990 RP001005079 RP001005496 RP001006425 RP001008266 RP001010507 RP001011358 RP001012763 RP001013449 RP001013656 RP001014632 RP001015721 RP001016516 RP001016572 RP001017032 RP001017263 RP001017400 RP001017422 RP001017688 RP001018440 RP001018522 RP001018693 RP001019432 RP001020096 RP001020479 RP001021147 RP001021296 RP001021978 RP001022783 RP001022922 RP001023142 RP001024177 RP001026498 RP001026577 RP001029378 RP001033201 RP001034609 RP001035069 RP001036458 RP001036706 RP001037375 RP001039706 RP001040004 RP001040677 RP001042226 RP001043150 RP001043156 RP001043574 RP001043612 RP001043725 RP001044593 RP001045115 RP001045188 RP001045577 RP001046851 RP001047094 RP001048523 RP001049014 RP001049294 RP001049982 RP001050133 RP001050804 RP001050815 RP001051077 RP001051169 RP001052892 RP001053190 RP001054294 RP001054433 RP001054838 RP001055585 RP001055801 RP001056117
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0261456 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 37247
Antibody Information
	polyclonal (Jin et al., 2012)
Other Information
Discoverer
Etymology
	Named "hippo" because of the dark, folded and overgrown cuticle of the mutant heads. (Udan et al., 2003)
Identification
Relationship to Other Genes
Source for database identity of
Source for database merge of	Source for merge of: hippo CG11228 (Wu et al., 2003) Source for merge of: hpo MST (Zhang et al., 2008)
Additional comments
Other Comments
	hpo acts cell autonomously in class IV neurons. (Emoto et al., 2006) hpo acts through trc and wts to regulate dendritic tiling and maintenance, respectively. (Emoto et al., 2006) hpo regulates expression of the ban miRNA. (Nolo et al., 2006) dsRNA has been made from templates generated with primers directed against this gene. (Polesello et al., 2006, Colombani et al., 2006) dsRNA made from templates generated with primers directed against this gene is tested in an S2 cell phosphorylation experiment to assess teh hpo signal transduction pathway. (Willecke et al., 2006) yki is a kinase substrate of wts, becoming phosphorylated by wts upon activation of the hpo pathway. (Huang et al., 2005) When dsRNA constructs are made and transiently transfected into S2 cells in RNAi experiments, spindle abnormalities and lagging chromatids are seen. (Bettencourt-Dias et al., 2004)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_137583 NM_001274163 RefSeq (Proteins) • NP_611427 NP_001261092 DDBJ / EMBL / GenBank • AAF57543 AAL39233 AGB93624 AI113866 AW940359 AY069088 Entrez Gene - A searchable database of RefSeq genes. • 37247 UniProtKB/Swiss-Prot • Q8T0S6
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Protein kinase, catalytic domain (IPR000719) Serine/threonine- / dual specificity protein kinase, catalytic domain (IPR002290) Protein kinase-like domain (IPR011009) SARAH domain (IPR011524) Protein kinase, ATP binding site (IPR017441) Mst1 SARAH domain (IPR024205) BDGP expression data - Patterns of gene expression in Drosophila embryogenesis • GH10354
Linkouts
	DPiM - DPiM, Drosophila Protein interaction Map • FBgn0261456 DroID - A comprehensive database of gene and protein interactions. • FBgn0261456 DRSC - Results from RNAi screens. • FBgn0261456 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0261456 FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0261456 FlyReactome - A curated knowledgebase of Drosophila melanogaster pathways • 92399 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 37247 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 37247 modMine - Data generated by the modENCODE project. • FBgn0261456 SignaLink - A protein-protein and protein-miRNA interaction database with multi-layered structure and multiple confidence scores. • Q8T0S6
Synonyms & Secondary IDs ( 9 )
Reported As
Symbol Synonym	CG11228 (Chaudhuri, 2005, Chen et al., 2004, Jia et al., 2003, Harvey et al., 2003, Wu et al., 2003, Egger et al., 2002, Brody et al., 2002, Giot et al., 2003, Udan et al., 2003, Keleman et al., 2009.8.5, Haussmann et al., 2008, Perkins et al., 2009, Formstecher et al., 2005, Ni et al., 2010.12.1, Ni et al., 2011.7.19, Wheeler et al., 2004) dMST (Jia et al., 2003, Zhang et al., 2008, Jia et al., 2004) hipo (Kanao et al., 2012) Hpo (Richter et al., 2011, Zhang et al., 2011, Martin et al., 2007, Hamaratoglu et al., 2007, Jukam and Desplan, 2007, Polesello and Tapon, 2007, Silva et al., 2006, Dong et al., 2007, Polesello et al., 2006, Silva, 2006, Jukam and Claude, 2008, Dutta and Baehrecke, 2008, Hariharan, 2006, Emoto et al., 2006, Oh and Irvine, 2009, Hamaratoglu et al., 2009, Zhang et al., 2009, Koike-Kumagai et al., 2009, Formstecher et al., 2005, Yu et al., 2010, Yue et al., 2012, Badouel et al., 2009, Zhai et al., 2008, Jin et al., 2012, Kango-Singh, 2012.10.31) hpo (Yu et al., 2008, Fernández et al., 2011, Zhang et al., 2011, Oh et al., 2009, Shaw et al., 2010, Chen et al., 2013, Poernbacher et al., 2012, Willecke et al., 2008, Cho et al., 2006, Polesello et al., 2006, Tyler et al., 2007, Wei et al., 2007, Thompson and Cohen, 2006, Udan et al., 2003, Mikeladze-Dvali et al., 2005, Edgar, 2006, Colombani et al., 2006, Pfleger et al., 2007, Bennett and Harvey, 2006, Zhao et al., 2007, Sun et al., 2008, Nicolay and Frolov, 2008, Wei et al., 2007, Zhang et al., 2008, Tyler and Baker, 2007, Oh and Irvine, 2008, Polesello and Tapon, 2007, Meignin et al., 2007, Soba et al., 2007, Goulev et al., 2008, Parrish et al., 2007, Pellock et al., 2007, Dutta and Baehrecke, 2008, Hamaratoglu et al., 2006, Hamaratoglu et al., 2009, Genevet et al., 2009, Willecke et al., 2006, Cruz et al., 2009, Zhang et al., 2009, Feng and Irvine, 2007, Das Thakur et al., 2010, Grzeschik et al., 2010, Ren et al., 2010, Ho et al., 2010, Yu et al., 2010, Baumgartner et al., 2010, Genevet et al., 2010, Zecca and Struhl, 2010, Davidson et al., 2009, Varelas et al., 2010, Fang and Adler, 2010, Baumgartner et al., 2010, Genevet et al., 2010, Ribeiro et al., 2010, Chen et al., 2010, Milton et al., 2010, Nicolay et al., 2010, Neto-Silva et al., 2010, Zeng et al., 2010, Boggiano et al., 2011, Ren et al., 2010, Rauskolb et al., 2011, Matsubara et al., 2011, Wu et al., 2008, Poon et al., 2011, Reddy and Irvine, 2011, Justiniano et al., 2012, Ye et al., 2012, Verghese et al., 2012) MST (Kanao et al., 2012, ) MST2 (Morrison et al., 2000)
Name Synonym	Hippo (Yu et al., 2008, Finan et al., 2011, Oh et al., 2009, Mattila et al., 2008, Martin et al., 2007, Colombani et al., 2006, Hamaratoglu et al., 2007, Jukam and Desplan, 2007, Willecke et al., 2007, Silva et al., 2006, Dong et al., 2007, Polesello et al., 2006, Silva, 2006, Deng et al., 2008, Nicolay and Frolov, 2008, Emoto et al., 2006, Oh and Irvine, 2008, Polesello and Tapon, 2007, Goulev et al., 2008, Dutta and Baehrecke, 2008, Hamaratoglu et al., 2009, Genevet et al., 2009, Willecke et al., 2006, Classen et al., 2009, Feng and Irvine, 2007, Das Thakur et al., 2010, Grzeschik et al., 2010, Ren et al., 2010, Ho et al., 2010, Yu et al., 2010, Baumgartner et al., 2010, Genevet et al., 2010, Ribeiro et al., 2010, Wheeler et al., 2004, Reddy and Irvine, 2011, Jin et al., 2012) hippo (Cho et al., 2006, Hafen and Stocker, 2003, Wu et al., 2003, Nolo et al., 2006, Herz et al., 2006, Wang and Montell, 2005, Bateman and McNeill, 2005, Hariharan, 2006, Sun et al., 2008, Menut et al., 2007, Bakal et al., 2008, Tyler and Baker, 2007, Meignin et al., 2007, Rafel and Milán, 2008, Badouel et al., 2009, Cruz et al., 2009, Zhang et al., 2009, Formstecher et al., 2005, Zecca and Struhl, 2010, Fang and Adler, 2010, Menéndez et al., 2010, Chen et al., 2010, Milton et al., 2010, Justiniano et al., 2012, Verghese et al., 2012) MST
Secondary FlyBase IDs
	FBgn0034453 FBgn0069363
References ( 172 )
Generate a list of	All references relating to this gene ( 172 )
List References by type	Research paper  ( 111 ) Supplementary material  ( 12 ) Review  ( 14 ) Personal communication to FlyBase  ( 10 ) Abstract  ( 17 ) FlyBase analysis  ( 2 ) Website  ( 1 ) Curated genome annotation  ( 2 ) Conference report  ( 2 )
Recent research papers ( 26 )
	Chen et al., 2013, RNA 19(2): 208--218 BCAS2 is essential for Drosophila viability and functions in pre-mRNA splicing. [FBrf0220579] Sansores-Garcia et al., 2013, Curr. Biol. 23(3): 229--235 Mask Is Required for the Activity of the Hippo Pathway Effector Yki/YAP. [FBrf0220780] Acharya et al., 2012, G3 (Bethesda) 2(11): 1459--1472 Evidence for autoregulation and cell signaling pathway regulation from genome-wide binding of the Drosophila retinoblastoma protein. [FBrf0220009] Jin et al., 2012, J. Biol. Chem. 287(8): 5784--5796 Dimerization and cytoplasmic localization regulate Hippo kinase signaling activity in organ size control. [FBrf0217990] Justiniano et al., 2012, PLoS ONE 7(2): e31417 Loss of the Tumor Suppressor Pten Promotes Proliferation of Drosophila melanogaster Cells In Vitro and Gives Rise to Continuous Cell Lines. [FBrf0217611] Kanao et al., 2012, PLoS ONE 7(2): e30958 The Nitric Oxide-Cyclic GMP Pathway Regulates FoxO and Alters Dopaminergic Neuron Survival in Drosophila. [FBrf0217639] Poernbacher et al., 2012, Curr. Biol. 22(5): 389--396 Drosophila Pez acts in hippo signaling to restrict intestinal stem cell proliferation. [FBrf0217766] Sarikaya et al., 2012, Dev. Biol. 363(1): 279--289 The roles of cell size and cell number in determining ovariole number in Drosophila. [FBrf0217485] Sebé-Pedrós et al., 2012, Cell Rep. 1(1): 13--20 Premetazoan origin of the hippo signaling pathway. [FBrf0219051] Straßburger et al., 2012, Dev. Biol. 367(2): 187--196 Insulin/IGF signaling drives cell proliferation in part via Yorkie/YAP. [FBrf0218526] Verghese et al., 2012, Cell Death Differ. 19(10): 1664--1676 Hippo signalling controls Dronc activity to regulate organ size in Drosophila. [FBrf0219371] Ye et al., 2012, Dev. Biol. 369(1): 115--123 Akt is negatively regulated by Hippo signaling for growth inhibition in Drosophila. [FBrf0219022] Yue et al., 2012, Dev. Cell 22(2): 255--267 The cell adhesion molecule echinoid functions as a tumor suppressor and upstream regulator of the hippo signaling pathway. [FBrf0217474] Boggiano et al., 2011, Dev. Cell 21(5): 888--895 Tao-1 phosphorylates Hippo/MST kinases to regulate the Hippo-Salvador-Warts tumor suppressor pathway. [FBrf0217346] Brás-Pereira et al., 2011, Commun. Integr. Biol. 4(5): 612--615 Homeostasis of the Drosophila adult retina by actin-capping protein and the Hippo pathway. [FBrf0216670] Fernández et al., 2011, Development 138(11): 2337--2346 Actin-Capping Protein and the Hippo pathway regulate F-actin and tissue growth in Drosophila. [FBrf0213674] Finan et al., 2011, Proc. Natl. Acad. Sci. U.S.A. 108(14): 5566--5571 From the Cover: Proteomics approach to study the functions of Drosophila myosin VI through identification of multiple cargo-binding proteins. [FBrf0213355] Matsubara et al., 2011, Genes Dev. 25(18): 1982--1996 The seven-pass transmembrane cadherin Flamingo controls dendritic self-avoidance via its binding to a LIM domain protein, Espinas, in Drosophila sensory neurons. [FBrf0215818] Napoletano et al., 2011, EMBO J. 30(5): 945--958 Polyglutamine Atrophin provokes neurodegeneration in Drosophila by repressing fat. [FBrf0213147] Poon et al., 2011, Dev. Cell 21(5): 896--906 The Sterile 20-like Kinase Tao-1 Controls Tissue Growth by Regulating the Salvador-Warts-Hippo Pathway. [FBrf0216620] Rauskolb et al., 2011, PLoS Biol. 9(6): e1000624 Zyxin links fat signaling to the hippo pathway. [FBrf0213900] Reddy and Irvine, 2011, Development 138(23): 5201--5212 Regulation of Drosophila glial cell proliferation by Merlin-Hippo signaling. [FBrf0216584] Richter et al., 2011, Nat. Cell Biol. 13(9): 1029--1039 The tumour suppressor L(3)mbt inhibits neuroepithelial proliferation and acts on insulator elements. [FBrf0215050] Sansores-Garcia et al., 2011, EMBO J. 30(12): 2325--2335 Modulating F-actin organization induces organ growth by affecting the Hippo pathway. [FBrf0213953] Zhang et al., 2011, Cell Death Differ. 18(8): 1346--1355 Wbp2 cooperates with Yorkie to drive tissue growth downstream of the Salvador-Warts-Hippo pathway. [FBrf0214266] Zhang et al., 2011, PLoS ONE 6(7): e22278 Yki/YAP, Sd/TEAD and Hth/MEIS Control Tissue Specification in the Drosophila Eye Disc Epithelium. [FBrf0214606] Show all research papers ...
Recent reviews (0)
	All reviews listed in FlyBase were published before 2011 Show reviews ...