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General Information
Symbol
Dmel\hpo
Species
D. melanogaster
Name
hippo
Annotation Symbol
CG11228
Feature Type
FlyBase ID
FBgn0261456
Gene Model Status
Stock Availability
Gene Snapshot
hippo (hpo) encodes a kinase in the Salvador-Warts-Hippo pathway. It controls tissue growth by controlling cell growth, proliferation and apoptosis. It has several roles in post-mitotic cells including fate specification of photoreceptors and tiling of dendritic neurons. [Date last reviewed: 2019-03-07]
Also Known As
dMST, MST, MST2
Key Links
Genomic Location
Cytogenetic map
Sequence location
2R:19,493,996..19,496,856 [-]
Recombination map
2-89
Sequence
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
Function
GO Summary Ribbons
Gene Group (FlyBase)
Protein Family (UniProt)
Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily. (Q8T0S6)
Summaries
Gene Group (FlyBase)
GERMINAL CENTER KINASES -
Germinal center kinases (GCKs) are serine/threonine kinases characterised by an N-terminal STE20 kinase domain. They have diverse roles in signaling pathways; some are MAPK kinase kinase kinases, activating MAPK kinase kinases. (Adapted from FBrf0225276 and FBrf0228279).
Pathway (FlyBase)
Hippo Signaling Pathway Core Components -
The Hippo signaling pathway is an intracellular kinase cascade in which hpo kinase in complex with sav, phosphorylates wts kinase which, in turn, phosphorylates yki transcriptional co-activator leading to its cytosolic retention. Activation of the Hippo pathway results in the down-regulation of cell proliferation and up-regulation of apoptosis, limiting tissue size. (Adapted from FBrf0224870).
Protein Function (UniProtKB)
Plays a key role in the Hippo/SWH (Sav/Wts/Hpo) signaling pathway, a signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein Hippo (Hpo), in complex with its regulatory protein Salvador (Sav), phosphorylates and activates Warts (Wts) in complex with its regulatory protein Mats, which in turn phosphorylates and inactivates the Yorkie (Yki) oncoprotein. The Hippo/SWH signaling pathway inhibits the activity of the transcriptional complex formed by Scalloped (sd) and Yki and the target genes of this pathway include cyclin-E (cycE), diap1 and bantam. Phosphorylates Sav, Wts and Th/DIAP1. Regulates the level of Th/DIAP1 apoptosis inhibitor.
(UniProt, Q8T0S6)
Summary (Interactive Fly)
a serine/threonine kinase - acts in conjunction with Salvador and Warts to restrict cell growth - promotes cell death by decreasing the level of Thread, an inhibitor of apoptosis - polycomb genes interact with the tumor suppressor genes and in the maintenance of sensory neuron dendrites
Gene Model and Products
Number of Transcripts
2
Number of Unique Polypeptides
1

Please see the GBrowse view of Dmel\hpo or the JBrowse view of Dmel\hpo for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Comments on Gene Model
Gene model reviewed during 5.45
Low-frequency RNA-Seq exon junction(s) not annotated.
Sequence Ontology: Class of Gene
Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
FBtr0086500
2503
669
FBtr0331920
2804
669
Additional Transcript Data and Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
RefSeq ID
GenBank
FBpp0085688
75.1
669
4.95
FBpp0304253
75.1
669
4.95
Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

669 aa isoforms: hpo-PA, hpo-PB
Additional Polypeptide Data and Comments
Reported size (kDa)
Comments
External Data
Subunit Structure (UniProtKB)
Homodimer. Interacts with Sav and Wts. Interacts (via SARAH domain) with Ex. Interacts with Kibra.
(UniProt, Q8T0S6)
Post Translational Modification
Autophosphorylated.
(UniProt, Q8T0S6)
Linkouts
Sequences Consistent with the Gene Model
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\hpo using the Feature Mapper tool.

External Data
Crossreferences
Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
Linkouts
Gene Ontology (37 terms)
Molecular Function (4 terms)
Terms Based on Experimental Evidence (3 terms)
CV Term
Evidence
References
Terms Based on Predictions or Assertions (2 terms)
CV Term
Evidence
References
inferred from electronic annotation with InterPro:IPR000719, InterPro:IPR002290, InterPro:IPR017441
(assigned by InterPro )
inferred from biological aspect of ancestor with PANTHER:PTN000684825
(assigned by GO_Central )
Biological Process (28 terms)
Terms Based on Experimental Evidence (24 terms)
CV Term
Evidence
References
inferred from mutant phenotype
inferred from mutant phenotype
inferred from genetic interaction with FLYBASE:ft; FB:FBgn0001075
inferred from genetic interaction with FLYBASE:wts; FB:FBgn0011739
inferred from mutant phenotype
inferred from mutant phenotype
(assigned by BHF-UCL )
inferred from mutant phenotype
(assigned by UniProt )
inferred from mutant phenotype
inferred from direct assay
inferred from mutant phenotype
(assigned by UniProt )
inferred from direct assay
inferred from direct assay
(assigned by UniProt )
inferred from direct assay
Terms Based on Predictions or Assertions (5 terms)
CV Term
Evidence
References
inferred from biological aspect of ancestor with PANTHER:PTN000684825
(assigned by GO_Central )
traceable author statement
(assigned by UniProt )
inferred from biological aspect of ancestor with PANTHER:PTN000685430
(assigned by GO_Central )
inferred from biological aspect of ancestor with PANTHER:PTN000684825
(assigned by GO_Central )
Cellular Component (5 terms)
Terms Based on Experimental Evidence (4 terms)
CV Term
Evidence
References
inferred from direct assay
inferred from direct assay
inferred from direct assay
(assigned by UniProt )
Terms Based on Predictions or Assertions (1 term)
CV Term
Evidence
References
inferred from biological aspect of ancestor with PANTHER:PTN000684825
(assigned by GO_Central )
Expression Data
Expression Summary Ribbons
Colored tiles in ribbon indicate that expression data has been curated by FlyBase for that anatomical location. Colorless tiles indicate that there is no curated data for that location.
For complete stage-specific expression data, view the modENCODE Development RNA-Seq section under High-Throughput Expression below.
Transcript Expression
in situ
Stage
Tissue/Position (including subcellular localization)
Reference
organism

Comment: maternally deposited

Additional Descriptive Data
hpo transcript was detected in all imaginal discs with unpatterned expression.
Marker for
 
Subcellular Localization
CV Term
Polypeptide Expression
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Evidence
References
inferred from direct assay
inferred from direct assay
inferred from direct assay
(assigned by UniProt )
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\hpo in GBrowse 2
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
FLIGHT - Cell culture data for RNAi and other high-throughput technologies
Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
Images
Alleles, Insertions, and Transgenic Constructs
Classical and Insertion Alleles ( 20 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 44 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of hpo
Transgenic constructs containing regulatory region of hpo
Deletions and Duplications ( 1 )
Phenotypes
For more details about a specific phenotype click on the relevant allele symbol.
Lethality
Allele
Sterility
Allele
Other Phenotypes
Allele
Phenotype manifest in
Allele
Orthologs
Human Orthologs (via DIOPT v7.1)
Homo sapiens (Human) (31)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Alignment
Complementation?
Transgene?
12 of 15
Yes
Yes
 
 
11 of 15
No
Yes
 
2 of 15
No
No
 
2 of 15
No
No
2 of 15
No
No
2 of 15
No
No
2 of 15
No
No
1 of 15
No
Yes
1 of 15
No
Yes
1 of 15
No
Yes
1 of 15
No
No
1 of 15
No
Yes
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
 
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
Model Organism Orthologs (via DIOPT v7.1)
Mus musculus (laboratory mouse) (29)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Alignment
Complementation?
Transgene?
13 of 15
Yes
Yes
11 of 15
No
Yes
2 of 15
No
No
2 of 15
No
No
2 of 15
No
No
2 of 15
No
No
2 of 15
No
No
1 of 15
No
Yes
1 of 15
No
Yes
1 of 15
No
Yes
1 of 15
No
Yes
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
Rattus norvegicus (Norway rat) (30)
9 of 13
Yes
Yes
9 of 13
Yes
Yes
2 of 13
No
No
2 of 13
No
No
2 of 13
No
No
2 of 13
No
No
1 of 13
No
No
1 of 13
No
Yes
1 of 13
No
Yes
1 of 13
No
Yes
1 of 13
No
Yes
1 of 13
No
Yes
1 of 13
No
No
1 of 13
No
No
1 of 13
No
No
1 of 13
No
No
1 of 13
No
No
1 of 13
No
No
1 of 13
No
No
1 of 13
No
No
1 of 13
No
No
1 of 13
No
No
1 of 13
No
No
1 of 13
No
No
1 of 13
No
No
1 of 13
No
No
1 of 13
No
No
1 of 13
No
No
1 of 13
No
No
1 of 13
No
No
Xenopus tropicalis (Western clawed frog) (19)
8 of 12
Yes
Yes
7 of 12
No
Yes
2 of 12
No
No
1 of 12
No
Yes
1 of 12
No
Yes
1 of 12
No
Yes
1 of 12
No
Yes
1 of 12
No
Yes
1 of 12
No
Yes
1 of 12
No
No
1 of 12
No
Yes
1 of 12
No
No
1 of 12
No
No
1 of 12
No
No
1 of 12
No
No
1 of 12
No
No
1 of 12
No
No
1 of 12
No
No
1 of 12
No
No
Danio rerio (Zebrafish) (35)
13 of 15
Yes
Yes
2 of 15
No
No
2 of 15
No
No
2 of 15
No
No
2 of 15
No
No
2 of 15
No
No
2 of 15
No
No
2 of 15
No
No
2 of 15
No
No
2 of 15
No
No
1 of 15
No
Yes
1 of 15
No
Yes
1 of 15
No
Yes
1 of 15
No
Yes
1 of 15
No
No
1 of 15
No
Yes
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
Caenorhabditis elegans (Nematode, roundworm) (17)
13 of 15
Yes
Yes
13 of 15
Yes
Yes
2 of 15
No
No
1 of 15
No
Yes
1 of 15
No
Yes
1 of 15
No
Yes
1 of 15
No
Yes
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
1 of 15
No
Yes
1 of 15
No
No
Arabidopsis thaliana (thale-cress) (27)
4 of 9
Yes
Yes
1 of 9
No
No
1 of 9
No
No
1 of 9
No
No
1 of 9
No
No
1 of 9
No
No
1 of 9
No
No
1 of 9
No
No
1 of 9
No
No
1 of 9
No
No
1 of 9
No
Yes
1 of 9
No
No
1 of 9
No
No
1 of 9
No
No
1 of 9
No
No
1 of 9
No
Yes
1 of 9
No
Yes
1 of 9
No
Yes
1 of 9
No
Yes
1 of 9
No
Yes
1 of 9
No
No
1 of 9
No
Yes
1 of 9
No
No
1 of 9
No
No
1 of 9
No
No
1 of 9
No
No
Saccharomyces cerevisiae (Brewer's yeast) (12)
4 of 15
Yes
No
3 of 15
No
No
2 of 15
No
Yes
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
Schizosaccharomyces pombe (Fission yeast) (12)
2 of 12
Yes
Yes
2 of 12
Yes
No
2 of 12
Yes
No
2 of 12
Yes
No
2 of 12
Yes
No
1 of 12
No
Yes
1 of 12
No
No
1 of 12
No
Yes
1 of 12
No
No
1 of 12
No
No
1 of 12
No
No
1 of 12
No
No
Orthologs in Drosophila Species (via OrthoDB v9.1) ( EOG091905XZ )
Organism
Common Name
Gene
AAA Syntenic Ortholog
Multiple Dmel Genes in this Orthologous Group
Drosophila melanogaster
fruit fly
Drosophila suzukii
Spotted wing Drosophila
Drosophila simulans
Drosophila sechellia
Drosophila erecta
Drosophila yakuba
Drosophila ananassae
Drosophila pseudoobscura pseudoobscura
Drosophila persimilis
Drosophila willistoni
Drosophila virilis
Drosophila mojavensis
Drosophila grimshawi
Orthologs in non-Drosophila Dipterans (via OrthoDB v9.1) ( EOG091503TZ )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Musca domestica
House fly
Musca domestica
House fly
Glossina morsitans
Tsetse fly
Lucilia cuprina
Australian sheep blowfly
Mayetiola destructor
Hessian fly
Aedes aegypti
Yellow fever mosquito
Anopheles darlingi
American malaria mosquito
Anopheles gambiae
Malaria mosquito
Culex quinquefasciatus
Southern house mosquito
Orthologs in non-Dipteran Insects (via OrthoDB v9.1) ( EOG090W04KX )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Bombyx mori
Silkmoth
Danaus plexippus
Monarch butterfly
Heliconius melpomene
Postman butterfly
Apis florea
Little honeybee
Apis mellifera
Western honey bee
Bombus impatiens
Common eastern bumble bee
Bombus terrestris
Buff-tailed bumblebee
Linepithema humile
Argentine ant
Megachile rotundata
Alfalfa leafcutting bee
Nasonia vitripennis
Parasitic wasp
Dendroctonus ponderosae
Mountain pine beetle
Dendroctonus ponderosae
Mountain pine beetle
Dendroctonus ponderosae
Mountain pine beetle
Dendroctonus ponderosae
Mountain pine beetle
Tribolium castaneum
Red flour beetle
Pediculus humanus
Human body louse
Rhodnius prolixus
Kissing bug
Cimex lectularius
Bed bug
Acyrthosiphon pisum
Pea aphid
Acyrthosiphon pisum
Pea aphid
Zootermopsis nevadensis
Nevada dampwood termite
Orthologs in non-Insect Arthropods (via OrthoDB v9.1) ( EOG090X04HK )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strigamia maritima
European centipede
Ixodes scapularis
Black-legged tick
Stegodyphus mimosarum
African social velvet spider
Tetranychus urticae
Two-spotted spider mite
Tetranychus urticae
Two-spotted spider mite
Daphnia pulex
Water flea
Orthologs in non-Arthropod Metazoa (via OrthoDB v9.1) ( EOG091G065P )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strongylocentrotus purpuratus
Purple sea urchin
Ciona intestinalis
Vase tunicate
Gallus gallus
Domestic chicken
Gallus gallus
Domestic chicken
Paralogs
Paralogs (via DIOPT v7.1)
Drosophila melanogaster (Fruit fly) (16)
4 of 10
3 of 10
2 of 10
2 of 10
2 of 10
2 of 10
2 of 10
2 of 10
2 of 10
2 of 10
1 of 10
1 of 10
1 of 10
1 of 10
1 of 10
1 of 10
Human Disease Associations
FlyBase Human Disease Model Reports
Disease Model Summary Ribbon
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 1 )
Allele
Disease
Evidence
References
Potential Models Based on Orthology ( 0 )
Human Ortholog
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 1 )
Allele
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease Associations of Human Orthologs (via DIOPT v7.1 and OMIM)
Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
Functional Complementation Data
Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
Dmel gene
Ortholog showing functional complementation
Supporting References
Interactions
Summary of Physical Interactions
esyN Network Diagram
Show neighbor-neighbor interactions:
Select Layout:
Legend:
Protein
RNA
Selected Interactor(s)
Interactions Browser

Please see the Physical Interaction reports below for full details
protein-protein
Physical Interaction
Assay
References
Summary of Genetic Interactions
esyN Network Diagram
esyN Network Key:
Suppression
Enhancement

Please look at the allele data for full details of the genetic interactions
Starting gene(s)
Interaction type
Interacting gene(s)
Reference
Starting gene(s)
Interaction type
Interacting gene(s)
Reference
suppressible
External Data
Subunit Structure (UniProtKB)
Homodimer. Interacts with Sav and Wts. Interacts (via SARAH domain) with Ex. Interacts with Kibra.
(UniProt, Q8T0S6 )
Linkouts
DroID - A comprehensive database of gene and protein interactions.
InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.
MIST (genetic) - An integrated Molecular Interaction Database
MIST (protein-protein) - An integrated Molecular Interaction Database
Pathways
Gene Group - Pathway Membership (FlyBase)
Hippo Signaling Pathway Core Components -
The Hippo signaling pathway is an intracellular kinase cascade in which hpo kinase in complex with sav, phosphorylates wts kinase which, in turn, phosphorylates yki transcriptional co-activator leading to its cytosolic retention. Activation of the Hippo pathway results in the down-regulation of cell proliferation and up-regulation of apoptosis, limiting tissue size. (Adapted from FBrf0224870).
External Data
Genomic Location and Detailed Mapping Data
Chromosome (arm)
2R
Recombination map
2-89
Cytogenetic map
Sequence location
2R:19,493,996..19,496,856 [-]
FlyBase Computed Cytological Location
Cytogenetic map
Evidence for location
56D13-56D13
Limits computationally determined from genome sequence between P{lacW}l(2)k00705k00705&P{lacW}mei-W68k05603 and P{EP}CG11007EP736
Experimentally Determined Cytological Location
Cytogenetic map
Notes
References
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Stocks and Reagents
Stocks (10)
Genomic Clones (17)
 

Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

cDNA Clones (157)
 

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequences
BDGP DGC clones
Other clones
Drosophila Genomics Resource Center cDNA clones

For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

cDNA Clones, End Sequenced (ESTs)
RNAi and Array Information
Linkouts
DRSC - Results frm RNAi screens
GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
Antibody Information
Laboratory Generated Antibodies
Commercially Available Antibodies
 
Other Information
Relationship to Other Genes
Source for database identify of
Source for database merge of
Source for merge of: hippo CG11228
Source for merge of: hpo MST
Additional comments
Other Comments
hpo acts cell autonomously in class IV neurons.
hpo acts through trc and wts to regulate dendritic tiling and maintenance, respectively.
hpo regulates expression of the ban miRNA.
dsRNA has been made from templates generated with primers directed against this gene.
dsRNA made from templates generated with primers directed against this gene is tested in an S2 cell phosphorylation experiment to assess teh hpo signal transduction pathway.
yki is a kinase substrate of wts, becoming phosphorylated by wts upon activation of the hpo pathway.
When dsRNA constructs are made and transiently transfected into S2 cells in RNAi experiments, spindle abnormalities and lagging chromatids are seen.
Origin and Etymology
Discoverer
Etymology
Named "hippo" because of the dark, folded and overgrown cuticle of the mutant heads.
Identification
External Crossreferences and Linkouts ( 54 )
Sequence Crossreferences
NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information
UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information
Other crossreferences
BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones
Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
FlyMine - An integrated database for Drosophila genomics
Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)
KEGG Genes - Molecular building blocks of life in the genomic space.
KEGG Pathways - Wiring diagrams of molecular interactions, reactions and relations.
modMine - A data warehouse for the modENCODE project
SignaLink - A signaling pathway resource with multi-layered regulatory networks.
Linkouts
DPiM - Drosophila Protein interaction map
DroID - A comprehensive database of gene and protein interactions.
DRSC - Results frm RNAi screens
FLIGHT - Cell culture data for RNAi and other high-throughput technologies
Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution
InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.
KEGG Pathways - Wiring diagrams of molecular interactions, reactions and relations.
MIST (genetic) - An integrated Molecular Interaction Database
MIST (protein-protein) - An integrated Molecular Interaction Database
Synonyms and Secondary IDs (12)
Reported As
Symbol Synonym
Hpo
(Gokhale and Pfleger, 2019, Matsui and Lai, 2019, Bae and Luo, 2018, Bohère et al., 2018, Cairns et al., 2018, Cho et al., 2018, de Vreede et al., 2018, Elbediwy and Thompson, 2018, Fulford et al., 2018, Gou et al., 2018, Kim and Jho, 2018, Simón-Carrasco et al., 2018, Jang et al., 2017, Kulaberoglu et al., 2017, Liu and Jin, 2017, Ma et al., 2017, Richardson and Portela, 2017, Tue et al., 2017, Bhadra et al., 2016, Fallahi et al., 2016, Hu et al., 2016, Jahanshahi et al., 2016, Jiang et al., 2016, Meng et al., 2016, Saadin and Starz-Gaiano, 2016, Aerne et al., 2015, Cao et al., 2015, Dent et al., 2015, Di Cara et al., 2015, Ni et al., 2015, Thompson and Sahai, 2015, Amoyel and Bach, 2014, Chen et al., 2014, Sadeqzadeh et al., 2014, Andersen et al., 2013, Degoutin et al., 2013, Deng et al., 2013, Enderle and McNeill, 2013, Jin et al., 2013, Johnston, 2013, Koontz et al., 2013, Losick et al., 2013, Matsui and Lai, 2013, Rister et al., 2013, Vilmos et al., 2013, Wu and Wu, 2013, Yin et al., 2013, Yu and Guan, 2013, Fausti et al., 2012, Jin et al., 2012, Kango-Singh, 2012.10.31, Liu et al., 2012, Yue et al., 2012, Chan et al., 2011, Genevet and Tapon, 2011, Halder and Johnson, 2011, Laprise, 2011, Losick et al., 2011, Richter et al., 2011, Salah and Aqeilan, 2011, Zhang et al., 2011, Zhao et al., 2011, Yu et al., 2010, Badouel et al., 2009, Hamaratoglu et al., 2009, Koike-Kumagai et al., 2009, Oh and Irvine, 2009, Zhang et al., 2009, Dutta and Baehrecke, 2008, Jukam and Claude, 2008, Zhai et al., 2008, Dong et al., 2007, Hamaratoglu et al., 2007, Jukam and Desplan, 2007, Martin et al., 2007, Polesello and Tapon, 2007, Emoto et al., 2006, Hariharan, 2006, Polesello et al., 2006, Silva, 2006, Silva et al., 2006, Formstecher et al., 2005)
hpo
(Meltzer et al., 2019, Sun et al., 2019, Xu et al., 2019, Azuma et al., 2018, Forest et al., 2018, Kushimura et al., 2018, Li et al., 2018, Reilein et al., 2018, Sarkar et al., 2018, Tsuboi et al., 2018, Wang et al., 2018, Yu and Pan, 2018, Baker, 2017, Hevia et al., 2017, Li et al., 2017, Moeller et al., 2017, Neisch et al., 2017, Rossi et al., 2017, Su et al., 2017, Zheng et al., 2017, Boone et al., 2016, Chung et al., 2016, Huang et al., 2016, Kuleesha et al., 2016, Levinson and Cagan, 2016, Liu et al., 2016, Losick et al., 2016, Mao et al., 2016, Poon et al., 2016, Sakuma et al., 2016, Sarov et al., 2016, Suijkerbuijk et al., 2016, Dent et al., 2015, Di Cara et al., 2015, Dong et al., 2015, Enomoto et al., 2015, Fischer et al., 2015, Gailite et al., 2015, Gaspar et al., 2015, Keder et al., 2015, Kwon et al., 2015, Li et al., 2015, Meng et al., 2015, Nie et al., 2015, Wang and Baker, 2015, Wittkorn et al., 2015, Zheng et al., 2015, Djabrayan et al., 2014, Huang and Kalderon, 2014, Hu et al., 2014, Li et al., 2014, Lin et al., 2014, Qing et al., 2014, Robbins et al., 2014, Sopko et al., 2014, Tipping and Perrimon, 2014, Vo et al., 2014, Chen et al., 2013, Guo et al., 2013, Huang et al., 2013, Ilanges et al., 2013, Jukam et al., 2013, Jukam et al., 2013, Kwon et al., 2013, Kwon et al., 2013, Lucas et al., 2013, Marcinkevicius and Zallen, 2013, Southall et al., 2013, Wehr et al., 2013, Yin et al., 2013, Denton et al., 2012, Herranz et al., 2012, Justiniano et al., 2012, Papatheodorou et al., 2012, Poernbacher et al., 2012, Verghese et al., 2012, Ye et al., 2012, Bao et al., 2011, Boggiano et al., 2011, Chen et al., 2011, Fernández et al., 2011, Jukam and Desplan, 2011, Laprise, 2011, Matsubara et al., 2011, Napoletano et al., 2011, Poon et al., 2011, Rauskolb et al., 2011, Reddy and Irvine, 2011, Zhang et al., 2011, Baumgartner et al., 2010, Baumgartner et al., 2010, Chen et al., 2010, Das Thakur et al., 2010, Fang and Adler, 2010, Genevet et al., 2010, Genevet et al., 2010, Grzeschik et al., 2010, Ho et al., 2010, Milton et al., 2010, Neto-Silva et al., 2010, Nicolay et al., 2010, Ren et al., 2010, Ren et al., 2010, Ribeiro et al., 2010, Shaw et al., 2010, Varelas et al., 2010, Yu et al., 2010, Zecca and Struhl, 2010, Zeng et al., 2010, Cruz et al., 2009, Davidson et al., 2009, Genevet et al., 2009, Hamaratoglu et al., 2009, Oh et al., 2009, Zhang et al., 2009, Dutta and Baehrecke, 2008, Goulev et al., 2008, Nicolay and Frolov, 2008, Oh and Irvine, 2008, Sun et al., 2008, Willecke et al., 2008, Wu et al., 2008, Yu et al., 2008, Zhang et al., 2008, Feng and Irvine, 2007, Meignin et al., 2007, Parrish et al., 2007, Pellock et al., 2007, Pfleger et al., 2007, Polesello and Tapon, 2007, Soba et al., 2007, Tyler and Baker, 2007, Tyler et al., 2007, Wei et al., 2007, Wei et al., 2007, Zhao et al., 2007, Bennett and Harvey, 2006, Cho et al., 2006, Colombani et al., 2006, Edgar, 2006, Hamaratoglu et al., 2006, Polesello et al., 2006, Thompson and Cohen, 2006, Willecke et al., 2006, Mikeladze-Dvali et al., 2005, Udan et al., 2003)
Name Synonyms
Hippo
(Matsui and Lai, 2019, Mirzoyan et al., 2019, Cairns et al., 2018, Enomoto et al., 2018, Kim and Jho, 2018, Moon et al., 2018, Stuelten et al., 2018, Takeda et al., 2018, Hergovich, 2017, Bonfini et al., 2016, Boone et al., 2016, Di Gregorio et al., 2016, Hergovich, 2016, Poon et al., 2016, Suijkerbuijk et al., 2016, Yadav et al., 2016, Buchon and Osman, 2015, Copf, 2015, Enomoto et al., 2015, Hariharan, 2015, Irvine and Harvey, 2015, Pasco et al., 2015, Thompson, 2015, Thompson and Sahai, 2015, Amoyel and Bach, 2014, Sadeqzadeh et al., 2014, Degoutin et al., 2013, Deng et al., 2013, Huang et al., 2013, Konsavage and Yochum, 2013, Kwon et al., 2013, Lucas et al., 2013, Pastor-Pareja and Xu, 2013, Pomerantz and Blau, 2013, Puram and Bonni, 2013, Takashima et al., 2013, Vilmos et al., 2013, Wu and Wu, 2013, Yang and Hata, 2013, Hergovich and Hemmings, 2012, Jin et al., 2012, Bao et al., 2011, Finan et al., 2011, Halder and Johnson, 2011, Reddy and Irvine, 2011, Baumgartner et al., 2010, Das Thakur et al., 2010, Genevet et al., 2010, Grzeschik et al., 2010, Ho et al., 2010, Ren et al., 2010, Ribeiro et al., 2010, Yu et al., 2010, Classen et al., 2009, Genevet et al., 2009, Hamaratoglu et al., 2009, Oh et al., 2009, Deng et al., 2008, Dutta and Baehrecke, 2008, Goulev et al., 2008, Mattila et al., 2008, Nicolay and Frolov, 2008, Oh and Irvine, 2008, Yu et al., 2008, Dong et al., 2007, Feng and Irvine, 2007, Hamaratoglu et al., 2007, Jukam and Desplan, 2007, Martin et al., 2007, Polesello and Tapon, 2007, Willecke et al., 2007, Colombani et al., 2006, Emoto et al., 2006, Polesello et al., 2006, Silva, 2006, Silva et al., 2006, Willecke et al., 2006, Wheeler et al., 2004)
Hippo kinase
MST
Secondary FlyBase IDs
  • FBgn0034453
  • FBgn0069363
Datasets (1)
Study focus (1)
Experimental Role
Project
Project Type
Title
  • bait_protein
Interaction map generated by purification of Hippo pathway factors, with identification of copurifying proteins by mass spectrometry.
References (420)