a serine/threonine kinase - acts in conjunction with Salvador and Warts to restrict cell growth - promotes cell death by decreasing the level of Thread, an inhibitor of apoptosis - polycomb genes interact with the tumor suppressor genes and in the maintenance of sensory neuron dendrites
AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.
Gene model reviewed during 5.45
Low-frequency RNA-Seq exon junction(s) not annotated.
Homodimer. Interacts with Sav and Wts. Interacts (via SARAH domain) with Ex. Interacts with Kibra.
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\hpo using the Feature Mapper tool.
GBrowse - Visual display of RNA-Seq signalsView Dmel\hpo in GBrowse 2
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
dsRNA has been made from templates generated with primers directed against this gene.
dsRNA made from templates generated with primers directed against this gene is tested in an S2 cell phosphorylation experiment to assess teh hpo signal transduction pathway.
When dsRNA constructs are made and transiently transfected into S2 cells in RNAi experiments, spindle abnormalities and lagging chromatids are seen.
Named "hippo" because of the dark, folded and overgrown cuticle of the mutant heads.