• Home
• Tools
  • Tools Overview
  • Query Tools

    
    • QuickSearch
    • QueryBuilder
    • TermLink
    • CytoSearch
    • RNA-Seq Search
    • Interactions Browser
    • ImageBrowse
    • Find A Person
    • Google™ FlyBase
  • Genomic/Map Tools

    
    • BLAST
    • GBrowse
    • GBrowse 2 Beta
    • CytoSearch
    • Feature Mapper
    • Aberrations Maps
    • Chromosome Maps
    • Coordinates Converter
  • Retrieve/Convert

    
    • Batch Download
    • Coordinates Converter
    • ID Converter
  • Data Submission

    
    • Fast-Track Your Paper
    • Submit Personal Comm
    • Add A New Person
    • Update Person Info
  • People

    
    • Find A Person
    • Add A New Person
    • Update Person Info
• Files
  • Files Overview
  • Current release
  • Archived releases
  • Map Conversion
  • FTP site:
  • Releases (FTP)
  • Genomes (FTP)
• Species
  • Phylogeny
  • Sequenced Species
  • Synteny Table
  • Color Illustrations
  • Abbreviations
• Documents
  • About FlyBase
  • Reference Manual:
  • Sections
  • Contents
  • Nomenclature
  • Release Notes
• Resources
  • All Resources
  • Model Organisms
  • Stock Collections
  • Vectors & Constructs
  • Other links:
  • BDGP
  • DGRC
  • DIS by issue
  • FlyExpress
  • Interactive Fly
  • modENCODE
  • Textpresso for Fly
• News
  • News
  • FlyBase Forum
  • FlyBase Positions
  • Meetings
  • Courses
  • Fly Board
  • White papers
  • Funding
  • bionet.dros
• Help
  • Google™ FlyBase
  • Site Map
  • FAQs
  • FlyBase Guides
  • Video Tutorials
  • Report help
  • New to Flies
  • Pers. comm.
  • Author guidelines
  • Contact FlyBase
• Archives
  • Prior Release
  • Other Archives
  • Coordinate Converter

Gene Dmel\capt

General Information
Symbol	Dmel\capt	Species	D. melanogaster
Name	capulet	Annotation symbol	CG33979
Feature type	protein_coding_gene	FlyBase ID	FBgn0261458
Gene Model Status	Current	Stock availability	15 publicly available
Also Known As	CAP, acu, l(2)06955, CG5061
Genomic Location
Chromosome (arm)	2L	Recombination map
Cytogenetic map	21F1-21F1	Sequence location	2L:1,151,678..1,158,262 [-]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents Beta	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene capulet is referred to in FlyBase by the symbol Dmel\capt (CG33979, FBgn0261458). It is a protein_coding_gene from Drosophila melanogaster. Based on sequence similarity, it is predicted to have molecular function: actin binding; adenylate cyclase binding. There is experimental evidence for 12 unique biological process terms, many of which group under: cellular component organization or biogenesis; single-organism developmental process; sensory organ development; biological regulation; organelle organization; actin filament-based process; multicellular organism reproduction; system development; regulation of developmental process; establishment or maintenance of cytoskeleton polarity; compound eye photoreceptor development; photoreceptor cell axon guidance. 21 alleles are reported. The phenotypes of these alleles are annotated with: yolk; filopodium. It has 3 annotated transcripts and 3 annotated polypeptides. Protein features are: Adenylate cyclase-associated CAP; Adenylate cyclase-associated CAP, C-terminal; Adenylate cyclase-associated CAP, N-terminal; C-CAP/cofactor C-like domain; CAP, conserved site; CARP motif; Cyclase-associated protein CAP/septum formation inhibitor MinC, C-terminal; WH2 domain. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of very high expression to a trough of moderately high expression. Peak expression observed within 00-06 hour embryonic stages, during late pupal stages. Summary of FlyAtlas Anatomical Expression Data: Two or more Affy2 ProbeSets identify exons of this gene. This is a summary of the tissue expression peaks exhibited in at least one of these ProbeSets. Expression at high levels in the following post-embryonic organs or tissues: larval/adult central nervous system, adult crop, larval/adult midgut, larval/adult hindgut, larval/adult Malpighian tubules, adult heart, larval/adult salivary gland, larval trachea, adult ovary, adult male accessory gland, larval carcass. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, adult eye, adult brain, larval/adult fat body, adult spermathecae, adult testis, adult carcass. Gene sequence location is 2L:1151678..1158262.
User Contributed Data
	Beta version, feedback welcome
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
Update Feed	Click the icon below to subscribe to this FlyBase record and receive updates automatically through your feed reader.
FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 21F1-21F1   Limits computationally determined from genome sequence between P{PZ}l(2)1068510685&P{lacW}Tango14k00619 and P{lacW}RFeSPk11704
Experimentally Determined Cytological Location
Cytogenetic map Notes References 21E3-22B7     (Medina et al., 2006) 21F1-21F2     (Treisman, 2000.3.3) 21F-21F     (Baum, 1999.9.26) 21F1-21F2   (determined by in situ hybridisation)   (Spradling et al., 1999) 21F1-21F2   (determined by in situ hybridisation)   (Perrimon et al., 1996) 21F1-21F2     (BDGP Project Members, 1994-1999)
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\capt for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
	Gene model reviewed during 5.45 Annotated transcripts do not represent all supported alternative splices within 5' UTR.
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) capt-RA FBtr0100022  NM_001038780   2040   424 capt-RB FBtr0100023  NM_001038781   3049   783 capt-RC FBtr0332274  NM_001272927   2422   424
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein capt-PA   FBpp0099390   45.6   424   7.07     NP_001033869   AAF51408 capt-PB   FBpp0099391   84.5   783   4.84     NP_001033870   AAF51409 capt-PC   FBpp0304563   45.6   424   7.07     NP_001259856   AGB92393
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Adenylate cyclase-associated CAP (IPR001837) WH2 domain (IPR003124) CARP motif (IPR006599) CAP, conserved site (IPR018106) Adenylate cyclase-associated CAP, C-terminal (IPR013912) Adenylate cyclase-associated CAP, N-terminal (IPR013992) Cyclase-associated protein CAP/septum formation inhibitor MinC, C-terminal (IPR016098) C-CAP/cofactor C-like domain (IPR017901)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA201122   AA202065   AA246213   AA246472   AA246603   AA263744   AA391827   AA392042   AA392638   AA439109   AA440001   AA440686   AA536563   AA539092   AA539225   AA539695   AA695785   AA696714   AA735577   AA801684   AA816845   AA816988   AA817022   AA817286   AA820425   AA820579   AA820749   AA940966   AA941829   AA942036   AA942409   AA949078   AA950168   AA950539   AA950708   AA951143   AA951950   AA979692   AE014134 AAF51408   AE014134 AAF51409   AF132566 AAD27865   AE014134 AGB92393   AI061667   AI061754   AI063741   AI108743   AI109121   AI135277   AI260299   AI294386   AI388148   AI389350   AI455463   AI455782   AI455807   AI455982   AI456061   AI511875   AI512056   AI512329   AI512445   AI512570   AI514349   AI514797   AI516705   AI517328   AI518218   AI518384   AI518613   AI519501   AI519839   AI519912   AI519931   AI520152   AI531301   AI531787   AI531922   AI532166   AI534122   AI542530   AI543393   AI543404   AI543886   AI543901   AI546233   BG632409   BG633041   BG635710   BG637391   BG640142   BG640964   BI141858   BI142053   BI161742   BI162799   BI163207   BI163755   BI166194   BI166433   BI167067   BI167375   BI167448   BI167451   BI167901   BI168187   BI168730   BI170425   BI170573   BI171084   BI213806   BI214101   BI214719   BI216694   BI216756   BI216761   BI227954   BI232569   BI237049   BI237075   BI237418   BI238712   BI239129   BI240080   BI240124   BI241702   BI242176   BI242394   BI242567   BI352791   BI356212   BI357269   BI357792   BI358011   BI361459   BI363669   BI364484   BI365076   BI366806   BI369676   BI372300   BI373247   BI373254   BI374388   BI483918   BI564723   BI566709   BI573057   BI578050   BI580192   BI584231   BI615104   BI622146   BI632118   BI632193   BI632338   BI632611   BI632628   BI633329   BI633623   BI633831   BI633975   BI635151   BI635175   BI635548   BI636245   BI637595   BI637994   BI638738   BI638791   BI639019   BI639244   BI639265   BI639821   BI639937   BI640009   BI641063   BI641091   BI641503   BI641747   BQ103716   BT021236 AAX33384   CK135908   CK660161   CK660539   CK660980   CK661581   CK662237   CO153277   CO156065   CO156126   CO157089   CO283220   CO290022   CO290793   CO290815   CO292208   CO294087   CO306767   CO306996   CO307376   CO307421   CO309645   CO311347   CO324713   CO325766   CO335469   CO335692   CO335716   CO336712   CO337456   CO337926   CO338637   EC068252   EC079698   EC088916   EC210848   EC214683   EC217859   EC219261   EC225240   EC226461   EC230884   EC235426   EC235565   EC238078   EC247314   EC247861   EC248045   EC248162   EC261308   EC261784   EC262212   EC264346   EC265756   EC265928   EC266244   ES691454   EV585559   EV592121   EV599231   G00453   GH975003   GH977648
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL	Q9VPX6 Q9VPX7 Q7KN55
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
in situ Stage Tissue/Position (including subcellular localization) Reference embryonic stage 1 -- 3   organism | ubiquitous   (Benlali et al., 2000) organism   (Fisher et al., 2012) Comment:maternally deposited embryonic stage 4 -- 6   organism | ubiquitous   (Fisher et al., 2012) embryonic stage 5 -- 8   amnioproctodeal invagination   (Benlali et al., 2000) ventral furrow   (Benlali et al., 2000) anterior transverse furrow   (Benlali et al., 2000) cephalic furrow   (Benlali et al., 2000) embryonic stage 7 -- 8   organism | ubiquitous   (Fisher et al., 2012) embryonic stage 9 -- 10   organism | ubiquitous   (Fisher et al., 2012) embryonic stage 11 -- 12   central brain primordium   (Fisher et al., 2012) organism | faint & ubiquitous   (Fisher et al., 2012) ventral nerve cord primordium   (Fisher et al., 2012) embryonic stage 13 -- 16   adult hindgut precursor   (Fisher et al., 2012) embryonic brain   (Fisher et al., 2012) embryonic central brain neuron   (Fisher et al., 2012) embryonic hindgut   (Fisher et al., 2012) embryonic/larval muscle system   (Fisher et al., 2012) embryonic/larval nervous system   (Fisher et al., 2012) ventral midline   (Fisher et al., 2012) ventral nerve cord   (Fisher et al., 2012) embryonic stage 13 -- 17   presumptive embryonic/larval central nervous system   (Benlali et al., 2000) wandering third instar larval stage   eye disc anterior to the morphogenetic furrow   (Benlali et al., 2000) antennal disc | restricted   (Benlali et al., 2000) Comment:concentric ring pattern
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Polypeptide Expression
immunolocalization Stage Tissue/Position (including subcellular localization) Reference embryonic stage 4   organism | ubiquitous   (Wills et al., 2002) embryonic stage 12 -- 13   mesoderm   (Wills et al., 2002) presumptive embryonic/larval central nervous system   (Wills et al., 2002) epithelium of embryonic/larval gut   (Wills et al., 2002) embryonic stage 16 -- 17   embryonic/larval central nervous system   (Wills et al., 2002) mass spectroscopy Stage Tissue/Position (including subcellular localization) Reference day 7 of adulthood -- day 49 of adulthood   adult heart   (Cammarato et al., 2011)
Additional Descriptive Data
Marker for
Subcellular Localization (GO Cellular Component)
CV term Evidence References
cytoplasm inferred from direct assay (Medina et al., 2008)
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools
Reference	See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes.
FlyAtlas Anatomy Microarray
FlyAtlas Anatomical Expression Data (FlyAtlas-RNA.adult) (FlyAtlas-RNA.larva)    Styles Linear Logarithmic Heatmap Back-to-back    Scales gene max expression Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Two or more Affy2 ProbeSets identify exons of this gene. This is a summary of the tissue expression peaks exhibited in at least one of these ProbeSets. Expression at high levels in the following post-embryonic organs or tissues: larval/adult central nervous system, adult crop, larval/adult midgut, larval/adult hindgut, larval/adult Malpighian tubules, adult heart, larval/adult salivary gland, larval trachea, adult ovary, adult male accessory gland, larval carcass. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, adult eye, adult brain, larval/adult fat body, adult spermathecae, adult testis, adult carcass. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (>999.999) Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
modENCODE Anatomy RNA-Seq
modENCODE Tissue Expression Data (modENCODE_mRNA-Seq_tissues)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    109 central nervous system, larvae L3    164 central nervous system, pupae P8    119 head, virgin 1-day female    25 head, virgin 4-day female    33 head, virgin 20-day female    28 head, mated 1-day female    31 head, mated 4-day female    26 head, mated 20-day female    27 head, mated 1-day male    36 head, mated 4-day male    42 head, mated 20-day male    38 salivary gland, larvae L3 wandering    57 salivary gland, white prepupae    115 digestive system, larvae L3 wandering    131 digestive system, 1-day adult    85 digestive system, 4-day adult    70 digestive system, 20-day adult    102 fat body, larvae L3 wandering    21 fat body, white prepupae    44 fat body, pupae P8    103 carcass, larvae L3 wandering    147 carcass, 1-day adult    44 carcass, 4-day adult    34 carcass, 20-day adult    40 ovary, virgin 4-day female    79 ovary, mated 4-day female    74 testis, mated 4-day male    32 accessory gland, mated 4-day male    45 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering  (109) central nervous system, larvae L3  (164) central nervous system, pupae P8  (119) head, virgin 1-day female    25 head, virgin 4-day female  (33) head, virgin 20-day female  (28) head, mated 1-day female  (31) head, mated 4-day female  26 head, mated 20-day female  (27) head, mated 1-day male  (36) head, mated 4-day male  (42) head, mated 20-day male  (38) salivary gland, larvae L3 wandering  (57) salivary gland, white prepupae  (115) digestive system, larvae L3 wandering  (131) digestive system, 1-day adult  (85) digestive system, 4-day adult  (70) digestive system, 20-day adult  (102) fat body, larvae L3 wandering    21 fat body, white prepupae  (44) fat body, pupae P8  (103) carcass, larvae L3 wandering  (147) carcass, 1-day adult  (44) carcass, 4-day adult  (34) carcass, 20-day adult  (40) ovary, virgin 4-day female  (79) ovary, mated 4-day female  (74) testis, mated 4-day male  (32) accessory gland, mated 4-day male  (45) Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering  (109) central nervous system, larvae L3  (164) central nervous system, pupae P8  (119) head, virgin 1-day female    25 head, virgin 4-day female    33 head, virgin 20-day female    28 head, mated 1-day female    31 head, mated 4-day female    26 head, mated 20-day female    27 head, mated 1-day male    36 head, mated 4-day male    42 head, mated 20-day male    38 salivary gland, larvae L3 wandering    57 salivary gland, white prepupae  (115) digestive system, larvae L3 wandering  (131) digestive system, 1-day adult    85 digestive system, 4-day adult    70 digestive system, 20-day adult  102 fat body, larvae L3 wandering    21 fat body, white prepupae    44 fat body, pupae P8  103 carcass, larvae L3 wandering  (147) carcass, 1-day adult    44 carcass, 4-day adult    34 carcass, 20-day adult    40 ovary, virgin 4-day female    79 ovary, mated 4-day female    74 testis, mated 4-day male    32 accessory gland, mated 4-day male    45 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    109 central nervous system, larvae L3    164 central nervous system, pupae P8    119 head, virgin 1-day female    25 head, virgin 4-day female    33 head, virgin 20-day female    28 head, mated 1-day female    31 head, mated 4-day female    26 head, mated 20-day female    27 head, mated 1-day male    36 head, mated 4-day male    42 head, mated 20-day male    38 salivary gland, larvae L3 wandering    57 salivary gland, white prepupae    115 digestive system, larvae L3 wandering    131 digestive system, 1-day adult    85 digestive system, 4-day adult    70 digestive system, 20-day adult    102 fat body, larvae L3 wandering    21 fat body, white prepupae    44 fat body, pupae P8    103 carcass, larvae L3 wandering    147 carcass, 1-day adult    44 carcass, 4-day adult    34 carcass, 20-day adult    40 ovary, virgin 4-day female    79 ovary, mated 4-day female    74 testis, mated 4-day male    32 accessory gland, mated 4-day male    45 Expression Level Scale  Extremely high  log, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    109 central nervous system, larvae L3    164 central nervous system, pupae P8    119 head, virgin 1-day female    25 head, virgin 4-day female    33 head, virgin 20-day female    28 head, mated 1-day female    31 head, mated 4-day female    26 head, mated 20-day female    27 head, mated 1-day male    36 head, mated 4-day male    42 head, mated 20-day male    38 salivary gland, larvae L3 wandering    57 salivary gland, white prepupae    115 digestive system, larvae L3 wandering    131 digestive system, 1-day adult    85 digestive system, 4-day adult    70 digestive system, 20-day adult    102 fat body, larvae L3 wandering    21 fat body, white prepupae    44 fat body, pupae P8    103 carcass, larvae L3 wandering    147 carcass, 1-day adult    44 carcass, 4-day adult    34 carcass, 20-day adult    40 ovary, virgin 4-day female    79 ovary, mated 4-day female    74 testis, mated 4-day male    32 accessory gland, mated 4-day male    45 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering  (109) central nervous system, larvae L3  (164) central nervous system, pupae P8  (119) head, virgin 1-day female    25 head, virgin 4-day female  (33) head, virgin 20-day female  28 head, mated 1-day female  31 head, mated 4-day female  26 head, mated 20-day female  27 head, mated 1-day male  (36) head, mated 4-day male  (42) head, mated 20-day male  (38) salivary gland, larvae L3 wandering  (57) salivary gland, white prepupae  (115) digestive system, larvae L3 wandering  (131) digestive system, 1-day adult  (85) digestive system, 4-day adult  (70) digestive system, 20-day adult  (102) fat body, larvae L3 wandering    21 fat body, white prepupae  (44) fat body, pupae P8  (103) carcass, larvae L3 wandering  (147) carcass, 1-day adult  (44) carcass, 4-day adult  (34) carcass, 20-day adult  (40) ovary, virgin 4-day female  (79) ovary, mated 4-day female  (74) testis, mated 4-day male  32 accessory gland, mated 4-day male  (45) Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering  109 central nervous system, larvae L3  (164) central nervous system, pupae P8  119 head, virgin 1-day female    25 head, virgin 4-day female    33 head, virgin 20-day female    28 head, mated 1-day female    31 head, mated 4-day female    26 head, mated 20-day female    27 head, mated 1-day male    36 head, mated 4-day male    42 head, mated 20-day male    38 salivary gland, larvae L3 wandering    57 salivary gland, white prepupae  115 digestive system, larvae L3 wandering  131 digestive system, 1-day adult    85 digestive system, 4-day adult    70 digestive system, 20-day adult  102 fat body, larvae L3 wandering    21 fat body, white prepupae    44 fat body, pupae P8  103 carcass, larvae L3 wandering  (147) carcass, 1-day adult    44 carcass, 4-day adult    34 carcass, 20-day adult    40 ovary, virgin 4-day female    79 ovary, mated 4-day female    74 testis, mated 4-day male    32 accessory gland, mated 4-day male    45 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    109 central nervous system, larvae L3    164 central nervous system, pupae P8    119 head, virgin 1-day female    25 head, virgin 4-day female    33 head, virgin 20-day female    28 head, mated 1-day female    31 head, mated 4-day female    26 head, mated 20-day female    27 head, mated 1-day male    36 head, mated 4-day male    42 head, mated 20-day male    38 salivary gland, larvae L3 wandering    57 salivary gland, white prepupae    115 digestive system, larvae L3 wandering    131 digestive system, 1-day adult    85 digestive system, 4-day adult    70 digestive system, 20-day adult    102 fat body, larvae L3 wandering    21 fat body, white prepupae    44 fat body, pupae P8    103 carcass, larvae L3 wandering    147 carcass, 1-day adult    44 carcass, 4-day adult    34 carcass, 20-day adult    40 ovary, virgin 4-day female    79 ovary, mated 4-day female    74 testis, mated 4-day male    32 accessory gland, mated 4-day male    45 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Tissue   Expression Level imaginal disc, larvae L3 wandering     central nervous system, larvae L3     central nervous system, pupae P8     head, virgin 1-day female     head, virgin 4-day female     head, virgin 20-day female     head, mated 1-day female     head, mated 4-day female     head, mated 20-day female     head, mated 1-day male     head, mated 4-day male     head, mated 20-day male     salivary gland, larvae L3 wandering     salivary gland, white prepupae     digestive system, larvae L3 wandering     digestive system, 1-day adult     digestive system, 4-day adult     digestive system, 20-day adult     fat body, larvae L3 wandering     fat body, white prepupae     fat body, pupae P8     carcass, larvae L3 wandering     carcass, 1-day adult     carcass, 4-day adult     carcass, 20-day adult     ovary, virgin 4-day female     ovary, mated 4-day female     testis, mated 4-day male     accessory gland, mated 4-day male
modENCODE Development RNA-Seq
modENCODE Temporal Expression Data (modENCODE_mRNA-Seq_U)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of very high expression to a trough of moderately high expression. Peak expression observed within 00-06 hour embryonic stages, during late pupal stages. [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    115 embryo 02-04hr    151 embryo 04-06hr    82 embryo 06-08hr    44 embryo 08-10hr    58 embryo 10-12hr    73 embryo 12-14hr    46 embryo 14-16hr    67 embryo 16-18hr    57 embryo 18-20hr    56 embryo 20-22hr    64 embryo 22-24hr    57 larva L1    60 larva L2    63 larva L3 12hr old    73 larva L3 puffstage 1-2    68 larva L3 puffstage 3-6    91 larva L3 puffstage 7-9    93 white prepupae new    85 white prepupae 12hr    69 white prepupae 24hr    84 pupae 2d postWPP    152 pupae 3d postWPP    48 pupae 4d postWPP    57 adult male 01day    35 adult male 05day    42 adult male 30day    43 adult female 01day    61 adult female 05day    75 adult female 30day    75 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (115) embryo 02-04hr  (151) embryo 04-06hr  (82) embryo 06-08hr  (44) embryo 08-10hr  (58) embryo 10-12hr  (73) embryo 12-14hr  (46) embryo 14-16hr  (67) embryo 16-18hr  (57) embryo 18-20hr  (56) embryo 20-22hr  (64) embryo 22-24hr  (57) larva L1  (60) larva L2  (63) larva L3 12hr old  (73) larva L3 puffstage 1-2  (68) larva L3 puffstage 3-6  (91) larva L3 puffstage 7-9  (93) white prepupae new  (85) white prepupae 12hr  (69) white prepupae 24hr  (84) pupae 2d postWPP  (152) pupae 3d postWPP  (48) pupae 4d postWPP  (57) adult male 01day  (35) adult male 05day  (42) adult male 30day  (43) adult female 01day  (61) adult female 05day  (75) adult female 30day  (75) Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr  (115) embryo 02-04hr  (151) embryo 04-06hr    82 embryo 06-08hr    44 embryo 08-10hr    58 embryo 10-12hr    73 embryo 12-14hr    46 embryo 14-16hr    67 embryo 16-18hr    57 embryo 18-20hr    56 embryo 20-22hr    64 embryo 22-24hr    57 larva L1    60 larva L2    63 larva L3 12hr old    73 larva L3 puffstage 1-2    68 larva L3 puffstage 3-6    91 larva L3 puffstage 7-9    93 white prepupae new    85 white prepupae 12hr    69 white prepupae 24hr    84 pupae 2d postWPP  (152) pupae 3d postWPP    48 pupae 4d postWPP    57 adult male 01day    35 adult male 05day    42 adult male 30day    43 adult female 01day    61 adult female 05day    75 adult female 30day    75 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    115 embryo 02-04hr    151 embryo 04-06hr    82 embryo 06-08hr    44 embryo 08-10hr    58 embryo 10-12hr    73 embryo 12-14hr    46 embryo 14-16hr    67 embryo 16-18hr    57 embryo 18-20hr    56 embryo 20-22hr    64 embryo 22-24hr    57 larva L1    60 larva L2    63 larva L3 12hr old    73 larva L3 puffstage 1-2    68 larva L3 puffstage 3-6    91 larva L3 puffstage 7-9    93 white prepupae new    85 white prepupae 12hr    69 white prepupae 24hr    84 pupae 2d postWPP    152 pupae 3d postWPP    48 pupae 4d postWPP    57 adult male 01day    35 adult male 05day    42 adult male 30day    43 adult female 01day    61 adult female 05day    75 adult female 30day    75 Expression Level Scale  Extremely high  log, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    115 embryo 02-04hr    151 embryo 04-06hr    82 embryo 06-08hr    44 embryo 08-10hr    58 embryo 10-12hr    73 embryo 12-14hr    46 embryo 14-16hr    67 embryo 16-18hr    57 embryo 18-20hr    56 embryo 20-22hr    64 embryo 22-24hr    57 larva L1    60 larva L2    63 larva L3 12hr old    73 larva L3 puffstage 1-2    68 larva L3 puffstage 3-6    91 larva L3 puffstage 7-9    93 white prepupae new    85 white prepupae 12hr    69 white prepupae 24hr    84 pupae 2d postWPP    152 pupae 3d postWPP    48 pupae 4d postWPP    57 adult male 01day    35 adult male 05day    42 adult male 30day    43 adult female 01day    61 adult female 05day    75 adult female 30day    75 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (115) embryo 02-04hr  (151) embryo 04-06hr  (82) embryo 06-08hr  (44) embryo 08-10hr  (58) embryo 10-12hr  (73) embryo 12-14hr  (46) embryo 14-16hr  (67) embryo 16-18hr  (57) embryo 18-20hr  (56) embryo 20-22hr  (64) embryo 22-24hr  (57) larva L1  (60) larva L2  (63) larva L3 12hr old  (73) larva L3 puffstage 1-2  (68) larva L3 puffstage 3-6  (91) larva L3 puffstage 7-9  (93) white prepupae new  (85) white prepupae 12hr  (69) white prepupae 24hr  (84) pupae 2d postWPP  (152) pupae 3d postWPP  (48) pupae 4d postWPP  (57) adult male 01day  (35) adult male 05day  (42) adult male 30day  (43) adult female 01day  (61) adult female 05day  (75) adult female 30day  (75) Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr  115 embryo 02-04hr  (151) embryo 04-06hr    82 embryo 06-08hr    44 embryo 08-10hr    58 embryo 10-12hr    73 embryo 12-14hr    46 embryo 14-16hr    67 embryo 16-18hr    57 embryo 18-20hr    56 embryo 20-22hr    64 embryo 22-24hr    57 larva L1    60 larva L2    63 larva L3 12hr old    73 larva L3 puffstage 1-2    68 larva L3 puffstage 3-6    91 larva L3 puffstage 7-9    93 white prepupae new    85 white prepupae 12hr    69 white prepupae 24hr    84 pupae 2d postWPP  (152) pupae 3d postWPP    48 pupae 4d postWPP    57 adult male 01day    35 adult male 05day    42 adult male 30day    43 adult female 01day    61 adult female 05day    75 adult female 30day    75 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    115 embryo 02-04hr    151 embryo 04-06hr    82 embryo 06-08hr    44 embryo 08-10hr    58 embryo 10-12hr    73 embryo 12-14hr    46 embryo 14-16hr    67 embryo 16-18hr    57 embryo 18-20hr    56 embryo 20-22hr    64 embryo 22-24hr    57 larva L1    60 larva L2    63 larva L3 12hr old    73 larva L3 puffstage 1-2    68 larva L3 puffstage 3-6    91 larva L3 puffstage 7-9    93 white prepupae new    85 white prepupae 12hr    69 white prepupae 24hr    84 pupae 2d postWPP    152 pupae 3d postWPP    48 pupae 4d postWPP    57 adult male 01day    35 adult male 05day    42 adult male 30day    43 adult female 01day    61 adult female 05day    75 adult female 30day    75 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     modENCODE Temporal Expression Data (Graveley et al., 2011)
modENCODE Cell Lines RNA-Seq
modENCODE Cell Line Expression Data (modENCODE_mRNA-Seq_cell.A) (modENCODE_mRNA-Seq_cell.B)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    335 Schneider line 2 Sg4    149 embryonic 1182-4H    357 embryonic GM2    117 embryonic Kc167    152 embryonic S1    147 embryonic S3    70 leg disc CME L1    160 wing disc CME-W2    118 wing disc ML-DmD8    99 wing disc ML-DmD9    262 wing disc ML-DmD16-c3    220 wing disc ML-DmD21    222 wing disc ML-DmD32    341 haltere disc ML-DmD17-c3    209 eye-antennal disc ML-DmD11    235 antennal disc ML-DmD20-c5    534 mixed discs ML-DmD4-c1    130 CNS ML-DmBG1-c1    137 CNS ML-DmBG2-c2    63 tumorous blood cells mbn2    202 ovary fGS/OSS    96 ovary OSC    93 ovary OSS    70 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+  (335) Schneider line 2 Sg4  (149) embryonic 1182-4H  (357) embryonic GM2  (117) embryonic Kc167  (152) embryonic S1  (147) embryonic S3  (70) leg disc CME L1  (160) wing disc CME-W2  (118) wing disc ML-DmD8  (99) wing disc ML-DmD9  (262) wing disc ML-DmD16-c3  (220) wing disc ML-DmD21  (222) wing disc ML-DmD32  (341) haltere disc ML-DmD17-c3  (209) eye-antennal disc ML-DmD11  (235) antennal disc ML-DmD20-c5  (534) mixed discs ML-DmD4-c1  (130) CNS ML-DmBG1-c1  (137) CNS ML-DmBG2-c2  (63) tumorous blood cells mbn2  (202) ovary fGS/OSS  (96) ovary OSC  (93) ovary OSS  (70) Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+  (335) Schneider line 2 Sg4  (149) embryonic 1182-4H  (357) embryonic GM2  (117) embryonic Kc167  (152) embryonic S1  (147) embryonic S3    70 leg disc CME L1  (160) wing disc CME-W2  (118) wing disc ML-DmD8    99 wing disc ML-DmD9  (262) wing disc ML-DmD16-c3  (220) wing disc ML-DmD21  (222) wing disc ML-DmD32  (341) haltere disc ML-DmD17-c3  (209) eye-antennal disc ML-DmD11  (235) antennal disc ML-DmD20-c5  (534) mixed discs ML-DmD4-c1  (130) CNS ML-DmBG1-c1  (137) CNS ML-DmBG2-c2    63 tumorous blood cells mbn2  (202) ovary fGS/OSS    96 ovary OSC    93 ovary OSS    70 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    335 Schneider line 2 Sg4    149 embryonic 1182-4H    357 embryonic GM2    117 embryonic Kc167    152 embryonic S1    147 embryonic S3    70 leg disc CME L1    160 wing disc CME-W2    118 wing disc ML-DmD8    99 wing disc ML-DmD9    262 wing disc ML-DmD16-c3    220 wing disc ML-DmD21    222 wing disc ML-DmD32    341 haltere disc ML-DmD17-c3    209 eye-antennal disc ML-DmD11    235 antennal disc ML-DmD20-c5    534 mixed discs ML-DmD4-c1    130 CNS ML-DmBG1-c1    137 CNS ML-DmBG2-c2    63 tumorous blood cells mbn2    202 ovary fGS/OSS    96 ovary OSC    93 ovary OSS    70 Expression Level Scale  Extremely high  log, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    335 Schneider line 2 Sg4    149 embryonic 1182-4H    357 embryonic GM2    117 embryonic Kc167    152 embryonic S1    147 embryonic S3    70 leg disc CME L1    160 wing disc CME-W2    118 wing disc ML-DmD8    99 wing disc ML-DmD9    262 wing disc ML-DmD16-c3    220 wing disc ML-DmD21    222 wing disc ML-DmD32    341 haltere disc ML-DmD17-c3    209 eye-antennal disc ML-DmD11    235 antennal disc ML-DmD20-c5    534 mixed discs ML-DmD4-c1    130 CNS ML-DmBG1-c1    137 CNS ML-DmBG2-c2    63 tumorous blood cells mbn2    202 ovary fGS/OSS    96 ovary OSC    93 ovary OSS    70 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+  (335) Schneider line 2 Sg4  (149) embryonic 1182-4H  (357) embryonic GM2  (117) embryonic Kc167  (152) embryonic S1  (147) embryonic S3  (70) leg disc CME L1  (160) wing disc CME-W2  (118) wing disc ML-DmD8  (99) wing disc ML-DmD9  (262) wing disc ML-DmD16-c3  (220) wing disc ML-DmD21  (222) wing disc ML-DmD32  (341) haltere disc ML-DmD17-c3  (209) eye-antennal disc ML-DmD11  (235) antennal disc ML-DmD20-c5  (534) mixed discs ML-DmD4-c1  (130) CNS ML-DmBG1-c1  (137) CNS ML-DmBG2-c2  (63) tumorous blood cells mbn2  (202) ovary fGS/OSS  (96) ovary OSC  (93) ovary OSS  (70) Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+  (335) Schneider line 2 Sg4  (149) embryonic 1182-4H  (357) embryonic GM2  117 embryonic Kc167  (152) embryonic S1  (147) embryonic S3    70 leg disc CME L1  (160) wing disc CME-W2  118 wing disc ML-DmD8    99 wing disc ML-DmD9  (262) wing disc ML-DmD16-c3  (220) wing disc ML-DmD21  (222) wing disc ML-DmD32  (341) haltere disc ML-DmD17-c3  (209) eye-antennal disc ML-DmD11  (235) antennal disc ML-DmD20-c5  (534) mixed discs ML-DmD4-c1  130 CNS ML-DmBG1-c1  137 CNS ML-DmBG2-c2    63 tumorous blood cells mbn2  (202) ovary fGS/OSS    96 ovary OSC    93 ovary OSS    70 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    335 Schneider line 2 Sg4    149 embryonic 1182-4H    357 embryonic GM2    117 embryonic Kc167    152 embryonic S1    147 embryonic S3    70 leg disc CME L1    160 wing disc CME-W2    118 wing disc ML-DmD8    99 wing disc ML-DmD9    262 wing disc ML-DmD16-c3    220 wing disc ML-DmD21    222 wing disc ML-DmD32    341 haltere disc ML-DmD17-c3    209 eye-antennal disc ML-DmD11    235 antennal disc ML-DmD20-c5    534 mixed discs ML-DmD4-c1    130 CNS ML-DmBG1-c1    137 CNS ML-DmBG2-c2    63 tumorous blood cells mbn2    202 ovary fGS/OSS    96 ovary OSC    93 ovary OSS    70 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Cell Line   Expression Level Schneider line 2 S2R+     Schneider line 2 Sg4     embryonic 1182-4H     embryonic GM2     embryonic Kc167     embryonic S1     embryonic S3     leg disc CME L1     wing disc CME-W2     wing disc ML-DmD8     wing disc ML-DmD9     wing disc ML-DmD16-c3     wing disc ML-DmD21     wing disc ML-DmD32     haltere disc ML-DmD17-c3     eye-antennal disc ML-DmD11     antennal disc ML-DmD20-c5     mixed discs ML-DmD4-c1     CNS ML-DmBG1-c1     CNS ML-DmBG2-c2     tumorous blood cells mbn2     ovary fGS/OSS     ovary OSC     ovary OSS
modENCODE Treatments RNA-Seq
modENCODE Treatment Expression Data (modENCODE_mRNA-Seq_treatments)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    68 cold shock, 4-day adult    48 heat shock, 4-day adult    78 Cadmium 50 mM 6 hrs, larvae L3    124 Cadmium 50 mM 12 hrs, larvae L3    83 Cadmium 50 mM 48 hrs, 4-day adult    81 Cadmium 100 mM 48 hrs, 4-day adult    81 Copper 0.5 mM 12 hrs, larvae L3    71 Copper 15 mM 48 hrs, 4-day adult    32 Zinc 5 mM 12 hrs, larvae L3    65 Zinc 4.5 mM 48 hrs, 4-day adult    35 Ethanol 2.5% 3 hrs, larvae L3    88 Ethanol 5% 3 hrs, larvae L3    94 Ethanol 10% 3 hrs, larvae L3    96 Caffeine 1.5 mg/ml 4 hrs, larvae L3    76 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    68 Caffeine 25 mg/ml 48 hrs, 4-day adult    42 Paraquat 5 mM 48 hrs, 4-day adult    61 Paraquat 10 mM 48 hrs, 4-day adult    74 Rotenone 2 μg 12 hrs, larvae L3    98 Rotenone 8 μg 12 hrs, larvae L3    134 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult  (68) cold shock, 4-day adult  (48) heat shock, 4-day adult  (78) Cadmium 50 mM 6 hrs, larvae L3  (124) Cadmium 50 mM 12 hrs, larvae L3  (83) Cadmium 50 mM 48 hrs, 4-day adult  (81) Cadmium 100 mM 48 hrs, 4-day adult  (81) Copper 0.5 mM 12 hrs, larvae L3  (71) Copper 15 mM 48 hrs, 4-day adult  (32) Zinc 5 mM 12 hrs, larvae L3  (65) Zinc 4.5 mM 48 hrs, 4-day adult  (35) Ethanol 2.5% 3 hrs, larvae L3  (88) Ethanol 5% 3 hrs, larvae L3  (94) Ethanol 10% 3 hrs, larvae L3  (96) Caffeine 1.5 mg/ml 4 hrs, larvae L3  (76) Caffeine 2.5 mg/ml 48 hrs, 4-day adult  (68) Caffeine 25 mg/ml 48 hrs, 4-day adult  (42) Paraquat 5 mM 48 hrs, 4-day adult  (61) Paraquat 10 mM 48 hrs, 4-day adult  (74) Rotenone 2 μg 12 hrs, larvae L3  (98) Rotenone 8 μg 12 hrs, larvae L3  (134) Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    68 cold shock, 4-day adult    48 heat shock, 4-day adult    78 Cadmium 50 mM 6 hrs, larvae L3  (124) Cadmium 50 mM 12 hrs, larvae L3    83 Cadmium 50 mM 48 hrs, 4-day adult    81 Cadmium 100 mM 48 hrs, 4-day adult    81 Copper 0.5 mM 12 hrs, larvae L3    71 Copper 15 mM 48 hrs, 4-day adult    32 Zinc 5 mM 12 hrs, larvae L3    65 Zinc 4.5 mM 48 hrs, 4-day adult    35 Ethanol 2.5% 3 hrs, larvae L3    88 Ethanol 5% 3 hrs, larvae L3    94 Ethanol 10% 3 hrs, larvae L3    96 Caffeine 1.5 mg/ml 4 hrs, larvae L3    76 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    68 Caffeine 25 mg/ml 48 hrs, 4-day adult    42 Paraquat 5 mM 48 hrs, 4-day adult    61 Paraquat 10 mM 48 hrs, 4-day adult    74 Rotenone 2 μg 12 hrs, larvae L3    98 Rotenone 8 μg 12 hrs, larvae L3  (134) Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    68 cold shock, 4-day adult    48 heat shock, 4-day adult    78 Cadmium 50 mM 6 hrs, larvae L3    124 Cadmium 50 mM 12 hrs, larvae L3    83 Cadmium 50 mM 48 hrs, 4-day adult    81 Cadmium 100 mM 48 hrs, 4-day adult    81 Copper 0.5 mM 12 hrs, larvae L3    71 Copper 15 mM 48 hrs, 4-day adult    32 Zinc 5 mM 12 hrs, larvae L3    65 Zinc 4.5 mM 48 hrs, 4-day adult    35 Ethanol 2.5% 3 hrs, larvae L3    88 Ethanol 5% 3 hrs, larvae L3    94 Ethanol 10% 3 hrs, larvae L3    96 Caffeine 1.5 mg/ml 4 hrs, larvae L3    76 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    68 Caffeine 25 mg/ml 48 hrs, 4-day adult    42 Paraquat 5 mM 48 hrs, 4-day adult    61 Paraquat 10 mM 48 hrs, 4-day adult    74 Rotenone 2 μg 12 hrs, larvae L3    98 Rotenone 8 μg 12 hrs, larvae L3    134 Expression Level Scale  Extremely high  log, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    68 cold shock, 4-day adult    48 heat shock, 4-day adult    78 Cadmium 50 mM 6 hrs, larvae L3    124 Cadmium 50 mM 12 hrs, larvae L3    83 Cadmium 50 mM 48 hrs, 4-day adult    81 Cadmium 100 mM 48 hrs, 4-day adult    81 Copper 0.5 mM 12 hrs, larvae L3    71 Copper 15 mM 48 hrs, 4-day adult    32 Zinc 5 mM 12 hrs, larvae L3    65 Zinc 4.5 mM 48 hrs, 4-day adult    35 Ethanol 2.5% 3 hrs, larvae L3    88 Ethanol 5% 3 hrs, larvae L3    94 Ethanol 10% 3 hrs, larvae L3    96 Caffeine 1.5 mg/ml 4 hrs, larvae L3    76 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    68 Caffeine 25 mg/ml 48 hrs, 4-day adult    42 Paraquat 5 mM 48 hrs, 4-day adult    61 Paraquat 10 mM 48 hrs, 4-day adult    74 Rotenone 2 μg 12 hrs, larvae L3    98 Rotenone 8 μg 12 hrs, larvae L3    134 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult  (68) cold shock, 4-day adult  (48) heat shock, 4-day adult  (78) Cadmium 50 mM 6 hrs, larvae L3  (124) Cadmium 50 mM 12 hrs, larvae L3  (83) Cadmium 50 mM 48 hrs, 4-day adult  (81) Cadmium 100 mM 48 hrs, 4-day adult  (81) Copper 0.5 mM 12 hrs, larvae L3  (71) Copper 15 mM 48 hrs, 4-day adult  32 Zinc 5 mM 12 hrs, larvae L3  (65) Zinc 4.5 mM 48 hrs, 4-day adult  (35) Ethanol 2.5% 3 hrs, larvae L3  (88) Ethanol 5% 3 hrs, larvae L3  (94) Ethanol 10% 3 hrs, larvae L3  (96) Caffeine 1.5 mg/ml 4 hrs, larvae L3  (76) Caffeine 2.5 mg/ml 48 hrs, 4-day adult  (68) Caffeine 25 mg/ml 48 hrs, 4-day adult  (42) Paraquat 5 mM 48 hrs, 4-day adult  (61) Paraquat 10 mM 48 hrs, 4-day adult  (74) Rotenone 2 μg 12 hrs, larvae L3  (98) Rotenone 8 μg 12 hrs, larvae L3  (134) Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    68 cold shock, 4-day adult    48 heat shock, 4-day adult    78 Cadmium 50 mM 6 hrs, larvae L3  124 Cadmium 50 mM 12 hrs, larvae L3    83 Cadmium 50 mM 48 hrs, 4-day adult    81 Cadmium 100 mM 48 hrs, 4-day adult    81 Copper 0.5 mM 12 hrs, larvae L3    71 Copper 15 mM 48 hrs, 4-day adult    32 Zinc 5 mM 12 hrs, larvae L3    65 Zinc 4.5 mM 48 hrs, 4-day adult    35 Ethanol 2.5% 3 hrs, larvae L3    88 Ethanol 5% 3 hrs, larvae L3    94 Ethanol 10% 3 hrs, larvae L3    96 Caffeine 1.5 mg/ml 4 hrs, larvae L3    76 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    68 Caffeine 25 mg/ml 48 hrs, 4-day adult    42 Paraquat 5 mM 48 hrs, 4-day adult    61 Paraquat 10 mM 48 hrs, 4-day adult    74 Rotenone 2 μg 12 hrs, larvae L3    98 Rotenone 8 μg 12 hrs, larvae L3  134 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    68 cold shock, 4-day adult    48 heat shock, 4-day adult    78 Cadmium 50 mM 6 hrs, larvae L3    124 Cadmium 50 mM 12 hrs, larvae L3    83 Cadmium 50 mM 48 hrs, 4-day adult    81 Cadmium 100 mM 48 hrs, 4-day adult    81 Copper 0.5 mM 12 hrs, larvae L3    71 Copper 15 mM 48 hrs, 4-day adult    32 Zinc 5 mM 12 hrs, larvae L3    65 Zinc 4.5 mM 48 hrs, 4-day adult    35 Ethanol 2.5% 3 hrs, larvae L3    88 Ethanol 5% 3 hrs, larvae L3    94 Ethanol 10% 3 hrs, larvae L3    96 Caffeine 1.5 mg/ml 4 hrs, larvae L3    76 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    68 Caffeine 25 mg/ml 48 hrs, 4-day adult    42 Paraquat 5 mM 48 hrs, 4-day adult    61 Paraquat 10 mM 48 hrs, 4-day adult    74 Rotenone 2 μg 12 hrs, larvae L3    98 Rotenone 8 μg 12 hrs, larvae L3    134 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Treatment   Expression Level extended cold, 4-day adult     cold shock, 4-day adult     heat shock, 4-day adult     Cadmium 50 mM 6 hrs, larvae L3     Cadmium 50 mM 12 hrs, larvae L3     Cadmium 50 mM 48 hrs, 4-day adult     Cadmium 100 mM 48 hrs, 4-day adult     Copper 0.5 mM 12 hrs, larvae L3     Copper 15 mM 48 hrs, 4-day adult     Zinc 5 mM 12 hrs, larvae L3     Zinc 4.5 mM 48 hrs, 4-day adult     Ethanol 2.5% 3 hrs, larvae L3     Ethanol 5% 3 hrs, larvae L3     Ethanol 10% 3 hrs, larvae L3     Caffeine 1.5 mg/ml 4 hrs, larvae L3     Caffeine 2.5 mg/ml 48 hrs, 4-day adult     Caffeine 25 mg/ml 48 hrs, 4-day adult     Paraquat 5 mM 48 hrs, 4-day adult     Paraquat 10 mM 48 hrs, 4-day adult     Rotenone 2 μg 12 hrs, larvae L3     Rotenone 8 μg 12 hrs, larvae L3
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (Graveley et al., 2011) mE1_20_mRNA_expression_cluster_10
External Data & Images
Linkouts	BDGP expression data • LD24380 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0028388
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele lethal (with captE636) captK304 lethal (with captK304) captE636 lethal (with Df(2L)ast5) captK304 lethal (with Df(2L)Exel6004) captK304 lethal (with Df(2L)Exel7006) captK304 lethal | larval stage | recessive capt06955 lethal | recessive capt06955 captE593 captE636 captK304 captk01217 viable, with Scer\GAL4pnr-MD237 captGD11526 Sterility Allele female sterile capt06955 female sterile | germline clone | recessive captE593 captE636 Other Phenotypes Allele neuroanatomy defective, with Scer\GAL4109(2)80 captScer\UAS.cBa neuroanatomy defective | larval stage captE636 captK304 neuroanatomy defective | larval stage (with captE636) captK304 neuroanatomy defective | larval stage (with captK304) captE636 neuroanatomy defective | larval stage (with Df(2L)ast5) captK304 visible | recessive | somatic clone captE593 captE636 Phenotype manifest in Allele dendrite | larval stage captK304 captE636 dendrite | larval stage (with captE636) captK304 dendrite | larval stage (with captK304) captE636 dendrite | larval stage (with Df(2L)ast5) captK304 egg | germline clone captE636 capt06955 captE593 eye | somatic clone captE636 captE593 eye disc & actin filament | somatic clone captE636 eye disc | somatic clone captE636 capt40-42 captE593 filopodium, with Scer\GAL4109(2)80 captScer\UAS.cBa follicle cell & actin filament | ectopic | somatic clone capt10 follicle cell & actin filament | somatic clone capt10 morphogenetic furrow | somatic clone captE636 captE593 neuron & eye disc | posterior | somatic clone captE636 captE593 oocyte & actin filament | ectopic | germ-line clone captunspecified captk01217 capt06955 capt10 oocyte & actin filament | germ-line clone captunspecified ovariole | germline clone capt06955 photoreceptor cell & eye disc | somatic clone captE636 captE593 wing disc | cell non-autonomous | dorsal/ventral compartment boundary captE636 wing margin bristle | somatic clone captE636 captE593 yolk captunspecified yolk granule | germline clone captunspecified
Classical Alleles ( 12 )
For All Classical Alleles Show
Allele of capt Class Mutagen Stocks Known lesion captf00786 piggyBac transposase 2 -- captk01217 P-element activity 2 Yes capt06955 P-element activity 1 Yes captd00534 1 -- captd05685 1 -- captE593 ethyl methanesulfonate 1 Yes captE636 ethyl methanesulfonate 1 Yes capt10 0 -- capt40-42 ethyl methanesulfonate 0 -- captB99 0 -- captK304 ethyl methanesulfonate 0 Yes captunspecified 0 --
Alleles Carried on Transgenic Constructs ( 9 )
For All Alleles Carried on Transgenic Constructs Show
Allele of capt Class Mutagen Stocks Known lesion captGD11526 in vitro construct - RNAi in vitro construct - regulatory fusion 2 Yes captScer\UAS.cBa in vitro construct - regulatory fusion 2 Yes captHMS00810 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes captKK103925 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes captAct5C.T:Ivir\HA1 in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes captC.Scer\UAS in vitro construct - regulatory fusion 0 Yes captGD1396 in vitro construct - RNAi in vitro construct - regulatory fusion 0 Yes captNIG.5061R in vitro construct - regulatory fusion in vitro construct - RNAi 0 Yes captScer\UAS.T:Disc\RFP-mCherry in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes
Aneuploid Aberrations
Disrupted in	Df(2L)ast1 (BDGP Project Members, 1994-1999) Df(2L)ast2 (BDGP Project Members, 1994-1999, Spradling et al., 1999) Df(2L)ast5 (Medina et al., 2008) Df(2L)ast10 (BDGP Project Members, 1994-1999) Df(2L)BSC481 (Christensen et al., 2008.4.15) Df(2L)Exel6004 (Medina et al., 2008, Ryder, 2004.4.26) Df(2L)Exel7006 (Medina et al., 2008) Df(2L)S3 (Benlali et al., 2000) In(2L)ast-1 (BDGP Project Members, 1994-1999)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD1396} NA P{GD11526} NA P{KK103925} NA P{TRiP.HMS00810} NA P{UAS-capt.B} NA P{UAS-capt.C} NA P{UAS-mCherry-capt} NA characterization construct P{NIG.5061R} NA
Insertions
	Type of insertions Name Expression data insertion of enhancer trap P{lacW}captk01217 No P{lacW}l(2)SH1357SH1357 No P{lacW}Tango14k00619 No P{PZ}capt06955 No insertion of mobile activating element P{XP}captd00534 NA P{XP}captd05685 NA miscellaneous insertions PBac{WH}captf00786 NA
Gene Ontology: Function, Process & Cellular Component ( 15 unique terms )
Terms Based on Experimental Evidence ( 13 terms )
Molecular Function ( 0 terms)
Biological Process
CV term Evidence References
actin filament organization inferred from mutant phenotype (Baum et al., 2000, Baum and Perrimon, 2001, Medina et al., 2008) actin polymerization or depolymerization inferred from mutant phenotype (Benlali et al., 2000) cell morphogenesis inferred from mutant phenotype (Rogers et al., 2003, D'Ambrosio and Vale, 2010) chaeta morphogenesis inferred from mutant phenotype (Benlali et al., 2000) compound eye development inferred from mutant phenotype (Benlali et al., 2000) muscle cell homeostasis inferred from genetic interaction with Dys (Kucherenko et al., 2011) oocyte microtubule cytoskeleton polarization inferred from mutant phenotype (Baum et al., 2000) oogenesis inferred from mutant phenotype (Benlali et al., 2000) photoreceptor cell axon guidance inferred from mutant phenotype (Marrone et al., 2011) regulation of cell shape inferred from mutant phenotype (Benlali et al., 2000) rhabdomere development inferred from mutant phenotype (Marrone et al., 2011) wing disc dorsal/ventral pattern formation inferred from mutant phenotype (Major and Irvine, 2005)
Cellular Component
CV term Evidence References
cytoplasm inferred from direct assay (Medina et al., 2008)
Terms Based on Predictions or Assertions ( 2 terms )
Molecular Function
CV term Evidence References
actin binding inferred from electronic annotation with InterPro:IPR001837, InterPro:IPR013912, InterPro:IPR013992, InterPro:IPR018106 (FlyBase Curators et al., 2004-) inferred from sequence or structural similarity (Baum et al., 2000) adenylate cyclase binding inferred from sequence or structural similarity with GeneDB_Spombe:SPCC306.09c (FlyBase, 1992-)
Biological Process ( 0 terms)
Cellular Component ( 0 terms)
Sequence Ontology: Class of Gene
	gene (Medina et al., 2006) nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
protein-protein
Interacting group Assay References
capt - Aats-his anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) capt - Act57B experimental knowledge based (Guruharsha et al., 2011) capt - Akap200 experimental knowledge based (Guruharsha et al., 2011) capt - Ald experimental knowledge based (Guruharsha et al., 2011) capt - AnxB10 experimental knowledge based (Guruharsha et al., 2011) capt - Arpc2 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) capt - Bacc experimental knowledge based (Guruharsha et al., 2011) capt - CG10425 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) capt - CG10638 experimental knowledge based (Guruharsha et al., 2011) capt - CG11279 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) capt - CG11771 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) capt - CG11876 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) capt - CG12034 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) capt - CG12171 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) capt - CG12207 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) capt - CG13539 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) capt - CG14647 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) capt - CG14715 experimental knowledge based (Guruharsha et al., 2011) capt - CG14968 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) capt - CG14969 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) capt - CG15141 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) capt - CG16817 experimental knowledge based (Guruharsha et al., 2011) capt - CG17124 anti tag coimmunoprecipitation, peptide massfingerprinting, experimental knowledge based (Mintseris et al., 2009.11.23, Guruharsha et al., 2011) capt - CG17162 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) capt - CG17337 experimental knowledge based (Guruharsha et al., 2011) capt - CG17470 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) capt - CG18335 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) capt - CG18347 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) capt - CG1910 experimental knowledge based (Guruharsha et al., 2011) capt - CG2540 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) capt - CG2852 experimental knowledge based (Guruharsha et al., 2011) capt - CG2862 experimental knowledge based (Guruharsha et al., 2011) capt - CG2931 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) capt - CG2982 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) capt - CG30339 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) capt - CG3542 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) capt - CG40160 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) capt - CG4278 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) capt - CG4598 experimental knowledge based (Guruharsha et al., 2011) capt - CG5174 experimental knowledge based (Guruharsha et al., 2011) capt - CG5382 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) capt - CG5646 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) capt - CG5886 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) capt - CG6084 experimental knowledge based (Guruharsha et al., 2011) capt - CG6321 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) capt - CG6543 experimental knowledge based (Guruharsha et al., 2011) capt - CG7091 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) capt - CG7197 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) capt - CG7272 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) capt - CG7288 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) capt - CG7889 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) capt - CG8036 experimental knowledge based (Guruharsha et al., 2011) capt - CG8117 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) capt - CG8654 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) capt - CG8680 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) capt - CG8891 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) capt - CG9588 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) capt - Chd64 experimental knowledge based (Guruharsha et al., 2011) capt - Cpr11B anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) capt - Crc experimental knowledge based (Guruharsha et al., 2011) capt - Csat anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) capt - CycK anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) capt - Cyt-b5-r anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) capt - D1 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) capt - Der-2 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) capt - Df31 experimental knowledge based (Guruharsha et al., 2011) capt - Dim1 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) capt - E(spl)mγ-HLH anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) capt - Eb1 experimental knowledge based (Guruharsha et al., 2011) capt - Ef1γ experimental knowledge based (Guruharsha et al., 2011) capt - Ef2b experimental knowledge based (Guruharsha et al., 2011) capt - EndoGI experimental knowledge based (Guruharsha et al., 2011) capt - Eno experimental knowledge based (Guruharsha et al., 2011) capt - FK506-bp2 experimental knowledge based (Guruharsha et al., 2011) capt - Fim experimental knowledge based (Guruharsha et al., 2011) capt - Fkbp13 experimental knowledge based (Guruharsha et al., 2011) capt - GM130 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) capt - Gdi experimental knowledge based (Guruharsha et al., 2011) capt - Gip anti tag coimmunoprecipitation, peptide massfingerprinting, experimental knowledge based (Mintseris et al., 2009.11.23, Guruharsha et al., 2011) capt - GstE6 experimental knowledge based (Guruharsha et al., 2011) capt - GstO3 experimental knowledge based (Guruharsha et al., 2011) capt - Hop experimental knowledge based (Guruharsha et al., 2011) capt - Inos experimental knowledge based (Guruharsha et al., 2011) capt - Irk2 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) capt - MFS3 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) capt - Mdh2 experimental knowledge based (Guruharsha et al., 2011) capt - Men experimental knowledge based (Guruharsha et al., 2011) capt - Mkk4 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) capt - Moe experimental knowledge based (Guruharsha et al., 2011) capt - Nacα experimental knowledge based (Guruharsha et al., 2011) capt - Ndfip anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) capt - Nlp experimental knowledge based (Guruharsha et al., 2011) capt - Nsun2 experimental knowledge based (Guruharsha et al., 2011) capt - Ntf-2 experimental knowledge based (Guruharsha et al., 2011) capt - Oat anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) capt - PHGPx experimental knowledge based (Guruharsha et al., 2011) capt - Pdi experimental knowledge based (Guruharsha et al., 2011) capt - Pgd experimental knowledge based (Guruharsha et al., 2011) capt - Picot anti tag coimmunoprecipitation, peptide massfingerprinting, experimental knowledge based (Mintseris et al., 2009.11.23, Guruharsha et al., 2011) capt - Proct anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) capt - Prosα1 experimental knowledge based (Guruharsha et al., 2011) capt - Prx2540-2 experimental knowledge based (Guruharsha et al., 2011) capt - Rbp1-like anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) capt - RhoGDI experimental knowledge based (Guruharsha et al., 2011) capt - SP2637 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) capt - Sh3β experimental knowledge based (Guruharsha et al., 2011) capt - Snx3 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) capt - Spf45 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) capt - TER94 experimental knowledge based (Guruharsha et al., 2011) capt - Uch experimental knowledge based (Guruharsha et al., 2011) capt - ZnT63C anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) capt - aur anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) capt - awd experimental knowledge based (Guruharsha et al., 2011) capt - bys anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) capt - chic experimental knowledge based (Guruharsha et al., 2011) capt - cib experimental knowledge based (Guruharsha et al., 2011) capt - dUTPase experimental knowledge based (Guruharsha et al., 2011) capt - eEF1δ experimental knowledge based (Guruharsha et al., 2011) capt - eIF-4B experimental knowledge based (Guruharsha et al., 2011) capt - eIF-5A experimental knowledge based (Guruharsha et al., 2011) capt - fabp experimental knowledge based (Guruharsha et al., 2011) capt - fax experimental knowledge based (Guruharsha et al., 2011) capt - igl anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) capt - loqs experimental knowledge based, anti tag coimmunoprecipitation, peptide massfingerprinting (Guruharsha et al., 2011, Mintseris et al., 2009.11.23) capt - mab-21 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) capt - mus209 experimental knowledge based (Guruharsha et al., 2011) capt - nes anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) capt - regucalcin experimental knowledge based (Guruharsha et al., 2011) capt - scf experimental knowledge based (Guruharsha et al., 2011) capt - scu experimental knowledge based (Guruharsha et al., 2011) capt - smt3 experimental knowledge based (Guruharsha et al., 2011) capt - tub anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) capt - yip2 experimental knowledge based (Guruharsha et al., 2011)
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions capt allele Gene References capt10 Abl (Wills et al., 2002) l(2)gl (Baum and Perrimon, 2001) sli (Wills et al., 2002) capt06955 Abl (Wills et al., 2002) S (Gaengel and Mlodzik, 2003) captB99 sli (Wills et al., 2002) captk01217 Abl (Wills et al., 2002) Pka-R1 (Baum et al., 2000) robo (Wills et al., 2002) sli (Wills et al., 2002) unspecified lea (Wills et al., 2002)
External Data
Linkouts	DroID - A comprehensive database of gene and protein interactions. • FBgn0261458 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 45233
Orthologs
OrthoDB Orthologs (48) - based on analysis using Dmel annotation version 5.41
OrthoDB Ortholog Groups
	OrthoDB orthology group searches (Waterhouse et al., 2011, Nucleic Acids Res. 39(Database issue): D283--D288) Drosophila inclusive ortholog search EOG63XVP3 Dipteran inclusive ortholog search EOG683DCS Insect inclusive ortholog search EOG666TGK Arthropod inclusive ortholog search EOG6V6WZ7 Metazoa inclusive ortholog search EOG63FVQF
Orthologs in Drosophila Species (EOG63XVP3)
Organism Common Name Gene AAA Syntenic Ortholog Multiple Dmel Genes in this Orthologous Group Drosophila melanogaster fruit fly  Dmel\capt     Drosophila simulans   Dsim\GD22924 Y   Drosophila sechellia   Dsec\GM16624 Y   Drosophila erecta   Dere\GG24610 Y   Drosophila yakuba   Dyak\GE15744 Y   Drosophila ananassae   Dana\GF14733 Y   Drosophila pseudoobscura pseudoobscura   Dpse\GA25429 Y   Drosophila persimilis   Dper\GL15023 Y   Drosophila willistoni   Dwil\GK24366 Y   Drosophila virilis   Dvir\GJ17828 Y   Drosophila mojavensis   Dmoj\GI21941 Y   Drosophila grimshawi   Dgri\GH10564 Y
Orthologs in non-Drosophila Dipterans (EOG683DCS)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Aedes aegypti Yellow fever mosquito  Aaeg\AAEL013074   Aedes aegypti Yellow fever mosquito  Aaeg\AAEL011821   Anopheles gambiae Malaria mosquito  Agam\AGAP010175   Culex quinquefasciatus Southern house mosquito  Cqui\CPIJ003125
Orthologs in non-Dipteran Insects (EOG666TGK)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Apis mellifera Western honey bee  Amel\LOC410158   Apis mellifera Western honey bee  Amel\GB53981   Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG003293   Acromyrmex echinatior Panamanian leafcutter ant  Aech\AECH11964   Atta cephalotes Leafcutter ant  Acep\ACEP23661   Camponotus floridanus Florida carpenter ant  Cflo\CFLO15968   Harpegnathos saltator Jerdons jumping ant  Hsal\HSAL17376   Linepithema humile Argentine ant  Lhum\LH16986   Pogonomyrmex barbatus Red harvester ant  Pbar\PB13247   Solenopsis invicta Red fire ant  Sinv\SINV15968   Acyrthosiphon pisum Pea aphid  Apim\ACYPI006133   Bombyx mori Silkmoth  Bmor\BGIBMGA003515   Pediculus humanus Human body louse  Phum\PHUM428000   Tribolium castaneum Red flour beetle  Tcas\TC001635
Orthologs in non-Insect Arthropods (EOG6V6WZ7)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Daphnia pulex Water flea  Dpux\Tspyl1   Ixodes scapularis Deer tick  Isca\ISCW023355
Orthologs in non-Arthropod Metazoa (EOG63FVQF)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Caenorhabditis elegans Nematode  Cele\cas-2   Caenorhabditis elegans Nematode  Cele\cas-1   Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_009423gn   Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_009422gn   Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_024705gn   Danio rerio Zebrafish  Drer\cap2   Danio rerio Zebrafish  Drer\cap1   Xenopus tropicalis Western clawed frog  Xtro\cap2   Xenopus tropicalis Western clawed frog  Xtro\cap1   Gallus gallus Domestic chicken  Ggal\CAP1   Gallus gallus Domestic chicken  Ggal\CAP2   Mus musculus House mouse  Mmus\Cap1   Mus musculus House mouse  Mmus\Cap2   Rattus norvegicus Norway rat  Rnor\Cap1   Homo sapiens Human  Hsap\CAP2   Homo sapiens Human  Hsap\CAP1
Human Orthologs (2)
Gene OMIM HGNC Hsap\CAP2     Hsap\CAP1
AAA Orthologs (11) based on analysis using Dmel annotation version 4.3
Organism Gene Drosophila simulans Dsim\GD22924 Drosophila sechellia Dsec\GM16624 Drosophila erecta Dere\GG24610 Drosophila yakuba Dyak\GE15744 Drosophila ananassae Dana\GF14733 Drosophila pseudoobscura pseudoobscura Dpse\GA25429 Drosophila persimilis Dper\GL15023 Drosophila willistoni Dwil\GK24366 Drosophila virilis Dvir\GJ17828 Drosophila mojavensis Dmoj\GI21941 Drosophila grimshawi Dgri\GH10564
Stocks & Reagents
Stocks Listed in FlyBase ( 15 )
Bloomington	5943 w*; P{UAS-capt.B}1 5942 w*; captE593 P{neoFRT}40A/CyO 5944 w*; captE636 P{neoFRT}40A/CyO 18370 w1118; PBac{WH}captf00786/CyO 12330 cn1 P{PZ}capt06955/CyO; ry506
Harvard	- P{XP}captd00534 - P{XP}captd05685 - PBac{WH}captf00786
Kyoto	108495 w*; P{UAS-capt.B}1
VDRC	v101588 P{KK103925}VIE-260B v21995 w1118; P{GD11526}v21995 v21996 w1118; P{GD11526}v21996
	More stocks available...
Genomic Clones ( 1 )
	BACR38A03 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 217 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	LD24380 RH08748
Other clones	DPiM_LD24380
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	GH03714 GH03848 GH12951 GH20494 GH28040 GM03278 GM04468 GM08230 GM20804 LD02336 LD05501 LD12406 LD15065 LD15547 LD17322 LD17988 LD18795 LD18894 LD21556 LD21940 LD22515 LD24039 LD24623 LD26041 LD26605 LD27834 LD30109 LD30805 LD32869 LD34858 LD35468 LD35508 LD35761 LD35888 LD37669 LD37876 LD38225 LD39660 LD39756 LD39783 LD40183 LD42685 LD43425 LD43695 LD44161 LD44325 LD44478 LD45551 LD45578 LD46490 LD47752 LP04059 LP07746 LP18472 LP19175 LP19991 LP21180 LP22296 RE02550 RE03248 RE06239 RE06552 RE07748 RE07836 RE07839 RE08766 RE09579 RE11868 RE12081 RE12756 RE19413 RE19811 RE20826 RE23908 RE24009 RE24017 RE25346 RE28655 RE33203 RE33231 RE33645 RE35231 RE35537 RE36727 RE36773 RE38835 RE39708 RE39944 RE42309 RE43694 RE44663 RE45676 RE50296 RE52422 RE55938 RE59231 RE60507 RE61964 RE71848 RE74340 RH44639 RH53974 RH62221 SD02277 SD03051 SD03229 SD03552 SD06637 SD08877 SD10132 SD10144 SD11103 SD12158 SD15386 SD15812 SD16048 SD16404 SD16440 SD16925 SD17868 SD19645 SD20246 SD21107 SD21171 SD21450 SD21779 SD21810 SD22511 SD22660 SD22759 SD24160 SD24237 SD24856 SD25340 SD25718 SD25835 SD26092 SD26435 SD26454 SD27392 SD27758 SD28003 SD28201
Other clones	147831 527109 542659 CK01.31B.C1 CK01.96D.H6 CK01.97A.D2 CK01.114A.B8 CK01.115D.G10 Dmel_dig_001029_0647_2638 Dmel_neb_013655_0666_3443 Dmel_neb_016572_0961_0422 EK072904 EK075163 EK075234 EK162625 EK194561 EK197420 EK199450 EK205956 EK218715 EK224232 EK252229 EK252963 EK254449 EK254542 EN01632 EN07263 EN07405 EN09919 EN10513 EN11008 EN11044 EN13105 EN14604 EN15611 EN17244 GH07973 GH18952 LD03688 LD05632 LD06002 LD07061 LD10752 LD12871 LD13575 LD20023 LD22007 LD23337 LD25074 LD27131 LD30377 LD31460 LD33741 LD39118 LD40212 RE01162 RE02034 RE07355 RE08393 RE39443 RE44363 RE48583 RE49608 RE60493 RE66882 RH23250 RH36432 RP004284207 RP004351975 SD13184 UUGC1127
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0261458 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 45233
Antibody Information
	polyclonal (Wills et al., 2002, Medina et al., 2008)
Other Information
Discoverer
Etymology
	The gene is named "act up" for its effect on actin. (Benlali et al., 2000)
Identification
	A mutation showing defects in larval dendrite development. 1 allele of punc has been isolated in this screen. (Medina et al., 2006)
Relationship to Other Genes
Source for database identity of	Source for identity of: BcDNA:LD24380 CG5061 (Li, 1999.11)
Source for database merge of	Source for merge of: capt Acap (Baum, 2000.4.17) Source for merge of: capt acu (Baum, 2000.3.9) Source for merge of: capt CG5074 (FlyBase Genome Annotators, 2005) Source for merge of: capt punc (Medina et al., 2008) Source for merge of: capulet l(2)06955 (Baum, 1999.9.26)
Additional comments	Annotations CG5061 and CG5074 merged as CG33979 in release 4.3 of the genome annotation. (FlyBase Genome Annotators, 2005)
Other Comments
	dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R+ cell morphology. (Kiger et al., 2003) dsRNA made from templates generated with primers directed against this gene is tested in an RNAi screen for effects on actin-based lamella formation. (Rogers et al., 2003) capt functions specifically to limit actin-filament formation catalysed by ena protein at apical cell junctions in the follicular epithelium. (Baum and Perrimon, 2001) Mutant show altered F-actin and oocyte polarity during oogenesis. (Baum et al., 2000) capt organises the polarised distribution of F-actin and mRNAs during oogenesis. (Baum et al., 2000) capt is required to prevent excessive polymerisation of actin filaments in the eye disc. It is also required for cells to change shape in the morphogenetic furrow and prevents premature neuronal differentiation in the eye disc. (Benlali et al., 2000) capt is required for cells to constrict apically in the morphogenetic furrow in the eye disc and is also required to prevent premature neuronal differentiation. (Treisman et al., 2000) Identification: identified as a mutation that affects both the actin cytoskeleton and oocyte polarity in female germline clones. (Baum et al., 1999) capt helps control the global distribution of actin filaments in cells. (Baum et al., 1999) Loss of capt function in clones results in the dramatic re-organisation of actin filaments in many tissues, leading to the loss of some actin structures and the accumulation of massive clumps of F-actin at characteristic ectopic sites. (Baum et al., 1999) The autosomal "FLP-DFS" technique (using the P{ovoD1-18} P{FRT(whs)} P{hsFLP} chromosomes) has been used to identify the specific maternal effect phenotype for the zygotic lethal mutation. capt is required for germ cell viability or early oogenesis. (Perrimon et al., 1996)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_001038780 NM_001038781 NM_001272927 RefSeq (Proteins) • NP_001033869 NP_001033870 NP_001259856 DDBJ / EMBL / GenBank • AA820579 AAD27865 AAF51408 AAF51408.2 AAF51409 AAF51409.1 AAX33384 AF132566 AGB92393 AI455463 BI573057 BT021236 G00453 Entrez Gene - A searchable database of RefSeq genes. • 45233 UniProtKB/TrEMBL • Q7KN55 Q9VPX6 Q9VPX7
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Adenylate cyclase-associated CAP (IPR001837) WH2 domain (IPR003124) CARP motif (IPR006599) CAP, conserved site (IPR018106) Adenylate cyclase-associated CAP, C-terminal (IPR013912) Adenylate cyclase-associated CAP, N-terminal (IPR013992) Cyclase-associated protein CAP/septum formation inhibitor MinC, C-terminal (IPR016098) C-CAP/cofactor C-like domain (IPR017901) BDGP expression data - Patterns of gene expression in Drosophila embryogenesis • LD24380
Linkouts
	DroID - A comprehensive database of gene and protein interactions. • FBgn0261458 DRSC - Results from RNAi screens. • FBgn0261458 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0028388 FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0261458 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 45233 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 45233 modMine - Data generated by the modENCODE project. • FBgn0261458
Synonyms & Secondary IDs ( 24 )
Reported As
Symbol Synonym	Acap (Anholt and Mackay, 2001, ) acu (Hudson and Cooley, 2002, Stevenson and Theurkauf, 2000, Benlali et al., 2000, Treisman, 2000.3.3, Baum et al., 2000, Treisman et al., 2000, Minakhina et al., 2005) BcDNA:LD24380 (Montana and Littleton, 2006) CAP (Fernandez, 2004, Jacinto and Baum, 2003, Braga and Harwood, 2001, Baum and Perrimon, 2001, Paunola et al., 2002, Baas and Luo, 2001, Anonymous, 2001, Anonymous, 2001, Rebelo and Janody, 2007) Cap (Baum, 2002, Baum et al., 1999) cap (Hudson and Cooley, 2002, Riechmann and Ephrussi, 2001, Baum et al., 2001, Baum et al., 2000, ) capping protein (Rogers et al., 2003) capt (Bakal et al., 2007, Fernández et al., 2011, Stuart et al., 2007, Quinones-Coello, 2007, Christensen et al., 2008.4.15, Bakal et al., 2007, Baer et al., 2007, Menut et al., 2007, Medina et al., 2008, Junion et al., 2007, Meisel, 2009, Kucherenko et al., 2011, Marrone et al., 2011, Lin et al., 2012) Capt (Ponting et al., 2001, Wang et al., 2012) CG5061 (Rogers et al., 2003, Quinones-Coello, 2007, Meisel, 2009) CG5074   CG33979 (FlyBase Genome Annotators, 2005, Keleman et al., 2009.8.5, Ni et al., 2010.12.1, Cammarato et al., 2011) cyclase-associated protein (Rogers et al., 2003) Dcap (Spradling et al., 1999) l(2)06955 (Spradling et al., 1999, Perrimon et al., 1996, Meister and Braun, 1995.10, BDGP Project Members, 1994-1999, ) punc (Medina et al., 2006)
Name Synonym	act up (Janody et al., 2004, Treisman and Lang, 2002, Benlali et al., 2000, Treisman et al., 2000, Minakhina et al., 2005) Act up (Stevenson and Theurkauf, 2000) Adenylyl cyclase-associated protein (Spradling et al., 1999) capulet (Baum, 1999.9.26, Baum et al., 1999, Herranz and Milan, 2006, Montana and Littleton, 2006, Medina et al., 2008, Cammarato et al., 2011, D'Ambrosio and Vale, 2010, Kucherenko et al., 2011) Capulet (Rogers et al., 2003, Marrone et al., 2011, Wang et al., 2012, Lin et al., 2012) Cyclase-associated protein (Janody and Treisman, 2006) Cyclase Associated Protein Capulet (Rebelo and Janody, 2007) punctate (Medina et al., 2006)
Secondary FlyBase IDs
	FBgn0010632 FBgn0022262 FBgn0027062 FBgn0028388 FBgn0031311 FBgn0053979 FBgn0086304 FBpp0077648 FBpp0077649 FBtr0077983 FBtr0077984
References ( 91 )
Generate a list of	All references relating to this gene ( 91 )
List References by type	Research paper  ( 35 ) Supplementary material  ( 12 ) Review  ( 12 ) Personal communication to FlyBase  ( 18 ) Abstract  ( 6 ) FlyBase analysis  ( 3 ) Conference report  ( 1 ) Curated genome annotation  ( 2 ) Website  ( 1 )
Recent research papers ( 8 )
	Staller et al., 2013, Genetics 193(1): 51--61 Depleting Gene Activities in Early Drosophila Embryos with the "Maternal-Gal4-shRNA" System. [FBrf0220341] Lin et al., 2012, J. Biomed. Sci. 19: 46 Capulet and Slingshot share overlapping functions during Drosophila eye morphogenesis. [FBrf0219121] Wang et al., 2012, Nat. Commun. 3: 769 Drosophila follicle stem cells are regulated by proliferation and niche adhesion as well as mitochondria and ROS. [FBrf0217898] Fernández et al., 2011, Development 138(11): 2337--2346 Actin-Capping Protein and the Hippo pathway regulate F-actin and tissue growth in Drosophila. [FBrf0213674] Kucherenko et al., 2011, Dev. Biol. 352(2): 228--242 Stress and muscular dystrophy: a genetic screen for dystroglycan and dystrophin interactors in Drosophila identifies cellular stress response components. [FBrf0214383] Marrone et al., 2011, BMC Neurosci. 12: 93 New Dystrophin/Dystroglycan interactors control neuron behavior in Drosophila eye. [FBrf0216731] Otani et al., 2011, Dev. Cell 20(2): 219--232 IKKɛ Regulates Cell Elongation through Recycling Endosome Shuttling. [FBrf0212985] Sansores-Garcia et al., 2011, EMBO J. 30(12): 2325--2335 Modulating F-actin organization induces organ growth by affecting the Hippo pathway. [FBrf0213953] Show all research papers ...
Recent reviews (0)
	All reviews listed in FlyBase were published before 2011 Show reviews ...