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Gene Dmel\RhoGAP18B

General Information
Symbol	Dmel\RhoGAP18B	Species	D. melanogaster
Name	RhoGAP18B	Annotation symbol	CG42274
Feature type	protein_coding_gene	FlyBase ID	FBgn0261461
Gene Model Status	Current	Stock availability	48 publicly available
Also Known As	whir, CG7481, CG7502
Genomic Location
Chromosome (arm)	X	Recombination map
Cytogenetic map	18A3-18A4	Sequence location	X:19,030,259..19,059,362 [-]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents modENCODE GBrowse	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene RhoGAP18B is referred to in FlyBase by the symbol Dmel\RhoGAP18B (CG42274, FBgn0261461). It is a protein_coding_gene from Drosophila melanogaster. There is experimental evidence that it has the molecular function: GTPase activator activity. There is experimental evidence that it is involved in the biological process: behavioral response to nicotine; behavioral response to ethanol; actin filament organization. 67 alleles are reported. The phenotypes of these alleles are annotated with: trichogen cell; mesothoracic tergum. It has 5 annotated transcripts and 5 annotated polypeptides. Protein features are: Rho GTPase activation protein; Rho GTPase-activating protein domain. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of low expression. Peak expression observed within 06-18 hour embryonic stages. Summary of FlyAtlas Anatomical Expression Data: Two or more Affy2 ProbeSets identify exons of this gene. This is a summary of the tissue expression peaks exhibited in at least one of these ProbeSets. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, adult eye, adult thoracico-abdominal ganglion, adult crop, larval/adult midgut, larval/adult hindgut, adult heart, larval/adult fat body, adult salivary gland, larval trachea. Gene sequence location is X:19030259..19059362.
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2012_01	Sequence features BKN33207 HFA19763 BKN45065 HFA20048 HFA20047 BKN30544 HFA20049
FB2011_10	Clones RP003671801 RP003072191 RP003192137 RP003443110 Polypeptides RhoGAP18B-PG Transcripts RhoGAP18B-RG
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 18A3-18A4   Limits computationally determined from genome sequence between P{EP}CG7326EP1133 and P{EP}CG7502EP1326
Experimentally Determined Cytological Location
Cytogenetic map Notes References
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\RhoGAP18B for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
	Gene model reviewed during 5.42 Gene merge based on EST/cDNA data
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) RhoGAP18B-RB FBtr0299622  NM_133123   2192   468 RhoGAP18B-RC FBtr0299623  NM_133124   4576   1317 RhoGAP18B-RD FBtr0299624  NM_001144748   3928   752 RhoGAP18B-RF FBtr0299625  NM_001144749   1673   468 RhoGAP18B-RG FBtr0310063     1410   298
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein RhoGAP18B-PB   FBpp0288897   52.2   468   8.27     NP_573351   AAF48919 RhoGAP18B-PC   FBpp0288898   147.3   1317   6.87     NP_573352   AAF48921 RhoGAP18B-PD   FBpp0288899   84.5   752   4.85     NP_001138220   ACL82950 RhoGAP18B-PF   FBpp0288900   52.2   468   8.27     NP_001138221   ACL82951 RhoGAP18B-PG   FBpp0301764   34.4   298   9.33
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Rho GTPase-activating protein domain (IPR000198) Rho GTPase activation protein (IPR008936)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA439889   AA539040   AA698251   AA699035   AA941531   AE014298 AAF48919   AE014298 AAF48921   AE014298 ACL82950   AE014298 ACL82951   AI531523   AI531524   AI532572   AI542316   AQ025465   AQ025545   AQ073192   AW942810   AY061332 AAL28880   BG639842   BH610005   BI163520   BI356380   BI369973   BI572109   BI606465   BI609295   BI637008   BI640502   BP551468   BT099667   CO154748   CO155692   CO156160   CO191067   CO263721   CO270067   CO270841   CO271069   CO273964   CO275179   CO275535   CO276233   CO283373   CO284580   CO290993   CO297107   CO297185   CO301827   CO302390   CO304574   CO305304   CO307956   CO308284   CO309370   CO312648   CO313100   CO313538   CO314432   CO316446   CO316874   CO319596   CO319973   CO321322   CO324467   CO324545   CO326895   CO327292   CO327318   CO327723   CO327751   CO327880   CO329965   CO333294   CO341217   CZ471960   CZ472704   CZ474428   CZ475841   CZ476451   CZ476452   CZ476755   CZ476869   CZ480148   CZ480149   CZ480168   CZ483668   CZ486329   CZ486330   CZ488739   DQ486141 ABF50837   DQ486142 ABF50838   DQ486143 ABF50839   EC065156   EC067417   EC072176   EC085486   EC085533   EC089911   EC195212   EC205357   EC209516   EC210495   EC214037   EC238133   EC242346   EC254052   EC258003   EC260153   EC265763   GH749150   GH751493   GH751815   GH753239   GH770221   GH772129   GH772890   GH774333   GH776541   GH778893   GH783887   GH788945   GH791097   GH793651   GH798646   GH799657   GH812145   GH813794   GH815869   GH816673   GH820192   GH820883   GH824402   GH827981   GH830067   GH832629   GH838341   GH838412   GH848490   GH849309   GH851124   GH856429   GH858477   GH870375   GH872926   GH874223   GH874309   GH882150   GH887764   GH892095   GH893003   GH897050   GH899866   GH901403   GH906697   GH906926   GH909979   GH928774   GH931360   GH933692   GH934006   GH934537   GH936238   GH937947   GH940097   GH940880
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL	Q9VWL9 Q00IN0 Q00IM9 Q9VWL7
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
Polypeptide Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
High-Throughput Expression Data
or
See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes. modENCODE Temporal Expression Data for FBgn0261461    Styles Linear Logarithmic Heatmap    Scales max expr for FBgn0261461 Very low expression bin max Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of low expression. Peak expression observed within 06-18 hour embryonic stages. [download data (TSV)] Guide to modENCODE expression level colors   No expression (0 - 0)   Extremely low expression (1 - 10)   Very low expression (11 - 100)   Low expression (101 - 400)   Moderate expression (401 - 1400)   Moderately high expression (1401 - 4000)   High expression (4001 - 10000)   Very high expression (10001 - 100000)   Extremely high expression (100001 - 2000000) Linear, scaled to maximum FBgn0261461 expression level Developmental Stage   Expression Level embryo 00-02hr    719 embryo 02-04hr    405 embryo 04-06hr    355 embryo 06-08hr    887 embryo 08-10hr    1274 embryo 10-12hr    1440 embryo 12-14hr    971 embryo 14-16hr    1854 embryo 16-18hr    1244 embryo 18-20hr    1148 embryo 20-22hr    894 embryo 22-24hr    915 larva L1    426 larva L2    361 larva L3 12hr old    332 larva L3 puffstage 1-2    316 larva L3 puffstage 3-6    603 larva L3 puffstage 7-9    783 white prepupae new    934 white prepupae 12hr    806 white prepupae 24hr    678 pupae 2d postWPP    463 pupae 3d postWPP    331 pupae 4d postWPP    696 adult male 01day    370 adult male 05day    396 adult male 30day    467 adult female 01day    494 adult female 05day    435 adult female 30day    458 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  Linear, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (719) embryo 02-04hr  (405) embryo 04-06hr  (355) embryo 06-08hr  (887) embryo 08-10hr  (1274) embryo 10-12hr  (1440) embryo 12-14hr  (971) embryo 14-16hr  (1854) embryo 16-18hr  (1244) embryo 18-20hr  (1148) embryo 20-22hr  (894) embryo 22-24hr  (915) larva L1  (426) larva L2  (361) larva L3 12hr old  (332) larva L3 puffstage 1-2  (316) larva L3 puffstage 3-6  (603) larva L3 puffstage 7-9  (783) white prepupae new  (934) white prepupae 12hr  (806) white prepupae 24hr  (678) pupae 2d postWPP  (463) pupae 3d postWPP  (331) pupae 4d postWPP  (696) adult male 01day  (370) adult male 05day  (396) adult male 30day  (467) adult female 01day  (494) adult female 05day  (435) adult female 30day  (458) Expression Level Scale  None   Extremely low   Very low   Low  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    719 embryo 02-04hr    405 embryo 04-06hr    355 embryo 06-08hr    887 embryo 08-10hr    1274 embryo 10-12hr  1440 embryo 12-14hr    971 embryo 14-16hr  (1854) embryo 16-18hr    1244 embryo 18-20hr    1148 embryo 20-22hr    894 embryo 22-24hr    915 larva L1    426 larva L2    361 larva L3 12hr old    332 larva L3 puffstage 1-2    316 larva L3 puffstage 3-6    603 larva L3 puffstage 7-9    783 white prepupae new    934 white prepupae 12hr    806 white prepupae 24hr    678 pupae 2d postWPP    463 pupae 3d postWPP    331 pupae 4d postWPP    696 adult male 01day    370 adult male 05day    396 adult male 30day    467 adult female 01day    494 adult female 05day    435 adult female 30day    458 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    719 embryo 02-04hr    405 embryo 04-06hr    355 embryo 06-08hr    887 embryo 08-10hr    1274 embryo 10-12hr    1440 embryo 12-14hr    971 embryo 14-16hr    1854 embryo 16-18hr    1244 embryo 18-20hr    1148 embryo 20-22hr    894 embryo 22-24hr    915 larva L1    426 larva L2    361 larva L3 12hr old    332 larva L3 puffstage 1-2    316 larva L3 puffstage 3-6    603 larva L3 puffstage 7-9    783 white prepupae new    934 white prepupae 12hr    806 white prepupae 24hr    678 pupae 2d postWPP    463 pupae 3d postWPP    331 pupae 4d postWPP    696 adult male 01day    370 adult male 05day    396 adult male 30day    467 adult female 01day    494 adult female 05day    435 adult female 30day    458 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    719 embryo 02-04hr    405 embryo 04-06hr    355 embryo 06-08hr    887 embryo 08-10hr    1274 embryo 10-12hr    1440 embryo 12-14hr    971 embryo 14-16hr    1854 embryo 16-18hr    1244 embryo 18-20hr    1148 embryo 20-22hr    894 embryo 22-24hr    915 larva L1    426 larva L2    361 larva L3 12hr old    332 larva L3 puffstage 1-2    316 larva L3 puffstage 3-6    603 larva L3 puffstage 7-9    783 white prepupae new    934 white prepupae 12hr    806 white prepupae 24hr    678 pupae 2d postWPP    463 pupae 3d postWPP    331 pupae 4d postWPP    696 adult male 01day    370 adult male 05day    396 adult male 30day    467 adult female 01day    494 adult female 05day    435 adult female 30day    458 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  log, scaled to maximum FBgn0261461 expression level Developmental Stage   Expression Level embryo 00-02hr    719 embryo 02-04hr    405 embryo 04-06hr    355 embryo 06-08hr    887 embryo 08-10hr    1274 embryo 10-12hr    1440 embryo 12-14hr    971 embryo 14-16hr    1854 embryo 16-18hr    1244 embryo 18-20hr    1148 embryo 20-22hr    894 embryo 22-24hr    915 larva L1    426 larva L2    361 larva L3 12hr old    332 larva L3 puffstage 1-2    316 larva L3 puffstage 3-6    603 larva L3 puffstage 7-9    783 white prepupae new    934 white prepupae 12hr    806 white prepupae 24hr    678 pupae 2d postWPP    463 pupae 3d postWPP    331 pupae 4d postWPP    696 adult male 01day    370 adult male 05day    396 adult male 30day    467 adult female 01day    494 adult female 05day    435 adult female 30day    458 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  log, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (719) embryo 02-04hr  (405) embryo 04-06hr  (355) embryo 06-08hr  (887) embryo 08-10hr  (1274) embryo 10-12hr  (1440) embryo 12-14hr  (971) embryo 14-16hr  (1854) embryo 16-18hr  (1244) embryo 18-20hr  (1148) embryo 20-22hr  (894) embryo 22-24hr  (915) larva L1  (426) larva L2  (361) larva L3 12hr old  (332) larva L3 puffstage 1-2  (316) larva L3 puffstage 3-6  (603) larva L3 puffstage 7-9  (783) white prepupae new  (934) white prepupae 12hr  (806) white prepupae 24hr  (678) pupae 2d postWPP  (463) pupae 3d postWPP  (331) pupae 4d postWPP  (696) adult male 01day  (370) adult male 05day  (396) adult male 30day  (467) adult female 01day  (494) adult female 05day  (435) adult female 30day  (458) Expression Level Scale  None   Extremely low   Very low   Low  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    719 embryo 02-04hr    405 embryo 04-06hr    355 embryo 06-08hr    887 embryo 08-10hr    1274 embryo 10-12hr  1440 embryo 12-14hr    971 embryo 14-16hr  1854 embryo 16-18hr    1244 embryo 18-20hr    1148 embryo 20-22hr    894 embryo 22-24hr    915 larva L1    426 larva L2    361 larva L3 12hr old    332 larva L3 puffstage 1-2    316 larva L3 puffstage 3-6    603 larva L3 puffstage 7-9    783 white prepupae new    934 white prepupae 12hr    806 white prepupae 24hr    678 pupae 2d postWPP    463 pupae 3d postWPP    331 pupae 4d postWPP    696 adult male 01day    370 adult male 05day    396 adult male 30day    467 adult female 01day    494 adult female 05day    435 adult female 30day    458 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    719 embryo 02-04hr    405 embryo 04-06hr    355 embryo 06-08hr    887 embryo 08-10hr    1274 embryo 10-12hr    1440 embryo 12-14hr    971 embryo 14-16hr    1854 embryo 16-18hr    1244 embryo 18-20hr    1148 embryo 20-22hr    894 embryo 22-24hr    915 larva L1    426 larva L2    361 larva L3 12hr old    332 larva L3 puffstage 1-2    316 larva L3 puffstage 3-6    603 larva L3 puffstage 7-9    783 white prepupae new    934 white prepupae 12hr    806 white prepupae 24hr    678 pupae 2d postWPP    463 pupae 3d postWPP    331 pupae 4d postWPP    696 adult male 01day    370 adult male 05day    396 adult male 30day    467 adult female 01day    494 adult female 05day    435 adult female 30day    458 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    719 embryo 02-04hr    405 embryo 04-06hr    355 embryo 06-08hr    887 embryo 08-10hr    1274 embryo 10-12hr    1440 embryo 12-14hr    971 embryo 14-16hr    1854 embryo 16-18hr    1244 embryo 18-20hr    1148 embryo 20-22hr    894 embryo 22-24hr    915 larva L1    426 larva L2    361 larva L3 12hr old    332 larva L3 puffstage 1-2    316 larva L3 puffstage 3-6    603 larva L3 puffstage 7-9    783 white prepupae new    934 white prepupae 12hr    806 white prepupae 24hr    678 pupae 2d postWPP    463 pupae 3d postWPP    331 pupae 4d postWPP    696 adult male 01day    370 adult male 05day    396 adult male 30day    467 adult female 01day    494 adult female 05day    435 adult female 30day    458 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     FlyAtlas Anatomical Expression Data for FBgn0261461    Styles Linear Logarithmic Heatmap Back-to-back    Scales max expr for FBgn0261461 Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Two or more Affy2 ProbeSets identify exons of this gene. This is a summary of the tissue expression peaks exhibited in at least one of these ProbeSets. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, adult eye, adult thoracico-abdominal ganglion, adult crop, larval/adult midgut, larval/adult hindgut, adult heart, larval/adult fat body, adult salivary gland, larval trachea. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (1000 - 25000) Heatmap Tissue   Expression Level Larval Central Nervous System no informative data Larval Midgut no informative data Larval Hindgut no informative data Larval Malpighian Tubules no informative data Larval Fat Body no informative data Larval Salivary Gland no informative data Larval Trachea no informative data Larval Carcass no informative data Adult Head no informative data Adult Eye no informative data Adult Brain no informative data Adult Thoracic-Abdominal Ganglion no informative data Adult Crop no informative data Adult Midgut no informative data Adult Hindgut no informative data Adult Malpighian Tubules no informative data Adult Fat Body no informative data Adult Salivary Gland no informative data Adult Heart no informative data Adult VirginFemale Spermatheca no informative data Adult InseminatedFemale Spermatheca no informative data Adult Ovary no informative data Adult Testis     Adult Male Accessory Gland no informative data Adult Carcass no informative data modENCODE Temporal Expression Data (Graveley et al., 2011) FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
Expression Clusters
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0259169
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele lethal | recessive RhoGAP18BPG43 semi-lethal | pupal stage, with Scer\GAL4pnr-MD237 RhoGAP18BGD12266 semi-viable RhoGAP18B3 viable RhoGAP18B1 RhoGAP18B2 RhoGAP18B4 RhoGAP18B5 RhoGAP18B6 viable, with Scer\GAL4pnr-MD237 RhoGAP18BGD12250 RhoGAP18BGD12256 RhoGAP18BGD15353 Other Phenotypes Allele chemical resistant RhoGAP18B1 RhoGAP18B2 RhoGAP18B3 RhoGAP18B4 RhoGAP18B5 RhoGAP18B6 RhoGAP18BEP1439 RhoGAP18BEP1621 RhoGAP18BΔRC chemical resistant, with Scer\GAL4whir3 RhoGAP18BdsRNA.RA smell perception defective RhoGAP18B1 visible, with Scer\GAL4pnr-MD237 RhoGAP18BGD12266 Phenotype manifest in Allele mesothoracic tergum, with Scer\GAL4pnr-MD237 RhoGAP18BGD12266 trichogen cell, with Scer\GAL4pnr-MD237 RhoGAP18BGD12266
Classical Alleles ( 58 )
For All Classical Alleles Show
Allele of RhoGAP18B Class Mutagen Stocks Known lesion RhoGAP18BNP4129 2 -- RhoGAP18B5-HA-2717 1 -- RhoGAP18B5-HA-2901 1 -- RhoGAP18B5-HA-5069 1 -- RhoGAP18B5-SZ-3083 1 -- RhoGAP18B5-SZ-3417 1 -- RhoGAP18B5-SZ-4080 1 -- RhoGAP18B5-SZ-4094 1 -- RhoGAP18Bd01002 P-element activity 1 -- RhoGAP18Bd05271 P-element activity 1 -- RhoGAP18Bd08872 P-element activity 1 -- RhoGAP18Bd11122a 1 -- RhoGAP18Be01679 1 -- RhoGAP18Be02324 piggyBac transposase 1 -- RhoGAP18Be02346 piggyBac transposase 1 -- RhoGAP18BEP1326 P-element activity 1 -- RhoGAP18Bf01190 piggyBac transposase 1 -- RhoGAP18Bf03742 piggyBac transposase 1 -- RhoGAP18Bf06094 piggyBac transposase 1 -- RhoGAP18BKG00160 P-element activity 1 -- RhoGAP18BMI01863 1 -- RhoGAP18BNP0770 1 -- RhoGAP18BNP1089 1 -- RhoGAP18BNP1097 1 -- RhoGAP18BNP1514 1 -- RhoGAP18BNP2188 1 -- RhoGAP18BNP3169 1 -- RhoGAP18BNP3178 1 -- RhoGAP18BNP4163 1 -- RhoGAP18BNP5055 1 -- RhoGAP18BNP5121 1 -- RhoGAP18BNP6001 1 -- RhoGAP18BNP6092 1 -- RhoGAP18BNP7136 1 -- RhoGAP18BNP7160 1 -- RhoGAP18BNP7275 1 -- RhoGAP18B1 P-element activity 0 Yes RhoGAP18B2 P-element activity 0 Yes RhoGAP18B3 P-element activity 0 Yes RhoGAP18B4 P-element activity 0 Yes RhoGAP18B5-HA-2090 0 -- RhoGAP18B5-HA-2119 0 -- RhoGAP18B5-HA-2284 0 -- RhoGAP18B5 P-element activity 0 Yes RhoGAP18B6 P-element activity 0 Yes RhoGAP18Bd02256 P-element activity 0 -- RhoGAP18Bd07621 P-element activity 0 -- RhoGAP18Bd09463 P-element activity 0 -- RhoGAP18Bd09663 P-element activity 0 -- RhoGAP18BdsRNA.RA 0 Yes RhoGAP18BEP1439 P-element activity 0 -- RhoGAP18BEP1621 P-element activity 0 -- RhoGAP18BGG01006 0 -- RhoGAP18BGG01250 0 -- RhoGAP18BGG01618 0 -- RhoGAP18BGS9097 0 -- RhoGAP18BPG43 Delta2-3 0 -- RhoGAP18BΔRC Delta2-3 0 Yes
Alleles Carried on Transgenic Constructs ( 9 )
For All Alleles Carried on Transgenic Constructs Show
Allele of RhoGAP18B Class Mutagen Stocks Known lesion RhoGAP18BdsRNA.Scer\UAS in vitro construct - regulatory fusion in vitro construct - RNAi 2 Yes RhoGAP18BGD12250 in vitro construct - RNAi in vitro construct - regulatory fusion 2 Yes RhoGAP18BGD12256 in vitro construct - RNAi in vitro construct - regulatory fusion 2 Yes RhoGAP18BGD12266 in vitro construct - RNAi in vitro construct - regulatory fusion 2 Yes RhoGAP18BGD15353 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes RhoGAP18BJF01658 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes RhoGAP18BKK110544 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes RhoGAP18BRA.Scer\UAS in vitro construct - regulatory fusion 0 Yes RhoGAP18BRC.Scer\UAS in vitro construct - regulatory fusion 0 Yes
Aneuploid Aberrations
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD12250} NA P{GD12266} NA P{GD15353} NA P{KK110544} NA P{TRiP.JF01658} NA P{UAS-RhoGAP18B.RA} NA P{UAS-RhoGAP18B.RC} NA P{UAS-RhoGAP18B-dsRNA} NA
Insertions
	Type of insertions Name Expression data insertion of mobile activating element P{EP}RhoGAP18BEP1326 NA P{EP}RhoGAP18BEP1439 NA P{EP}RhoGAP18BEP1621 NA P{GSV6}RhoGAP18BGS9097 NA P{Mae-UAS.6.11}RhoGAP18BGG01006 NA P{Mae-UAS.6.11}RhoGAP18BGG01250 NA P{Mae-UAS.6.11}RhoGAP18BGG01618 NA P{XP}RhoGAP18Bd01002 NA P{XP}RhoGAP18Bd02256 NA P{XP}RhoGAP18Bd05271 NA P{XP}RhoGAP18Bd07621 NA P{XP}RhoGAP18Bd08872 NA P{XP}RhoGAP18Bd09463 NA P{XP}RhoGAP18Bd09663 NA P{XP}RhoGAP18Bd11122a NA miscellaneous insertions Mi{MIC}RhoGAP18BMI01863 NA P{RS5}RhoGAP18B5-HA-2090 NA P{RS5}RhoGAP18B5-HA-2119 NA P{RS5}RhoGAP18B5-HA-2284 NA P{RS5}RhoGAP18B5-HA-2717 NA P{RS5}RhoGAP18B5-HA-2901 NA P{RS5}RhoGAP18B5-HA-5069 NA P{RS5}RhoGAP18B5-SZ-3083 NA P{RS5}RhoGAP18B5-SZ-3417 NA P{RS5}RhoGAP18B5-SZ-4080 NA P{RS5}RhoGAP18B5-SZ-4094 NA P{SUPor-P}RhoGAP18BKG00160 NA PBac{RB}RhoGAP18Be01679 NA PBac{RB}RhoGAP18Be02324 NA PBac{RB}RhoGAP18Be02346 NA PBac{WH}RhoGAP18Bf01190 NA PBac{WH}RhoGAP18Bf03742 NA PBac{WH}RhoGAP18Bf06094 NA insertion of enhancer trap binary system P{GawB}RhoGAP18BNP0770 No P{GawB}RhoGAP18BNP1089 No P{GawB}RhoGAP18BNP1097 No P{GawB}RhoGAP18BNP1514 No P{GawB}RhoGAP18BNP2188 No P{GawB}RhoGAP18BNP3169 No P{GawB}RhoGAP18BNP3178 No P{GawB}RhoGAP18BNP4129 No P{GawB}RhoGAP18BNP4163 No P{GawB}RhoGAP18BNP5055 No P{GawB}RhoGAP18BNP5121 No P{GawB}RhoGAP18BNP6001 No P{GawB}RhoGAP18BNP6092 No P{GawB}RhoGAP18BNP7136 No P{GawB}RhoGAP18BNP7160 No P{GawB}RhoGAP18BNP7275 No P{GawB}RhoGAP18BPG43 No
Gene Ontology: Function, Process & Cellular Component ( 6 unique terms )
Terms Based on Experimental Evidence ( 4 terms )
Molecular Function
CV term Evidence References
GTPase activator activity inferred from direct assay (Rothenfluh et al., 2006)
Biological Process
CV term Evidence References
actin filament organization inferred from mutant phenotype (Kiger et al., 2003) behavioral response to ethanol inferred from mutant phenotype (Rothenfluh et al., 2004) behavioral response to nicotine inferred from mutant phenotype (Rothenfluh et al., 2004)
Cellular Component ( 0 terms)
Terms Based on Predictions or Assertions ( 3 terms )
Molecular Function
CV term Evidence References
GTPase activator activity inferred from sequence or structural similarity with NCBI:NP_064656 (FlyBase Genome Annotators, 2002-2003)
Biological Process
CV term Evidence References
signal transduction inferred from electronic annotation with InterPro:IPR000198, InterPro:IPR008936 (FlyBase Curators et al., 2004-)
Cellular Component
CV term Evidence References
intracellular inferred from electronic annotation with InterPro:IPR000198, InterPro:IPR008936 (FlyBase Curators et al., 2004-)
Sequence Ontology: Class of Gene
	gene   nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Protein-protein
Interacting group Assay References
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions RhoGAP18B allele Gene References
External Data
Linkouts	DroID - A comprehensive database of gene and protein interactions. • FBgn0261461 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 32898
Orthologs
Genome-wide drosophilid orthologs	Dgri\GH24224 Dper\GL14654 Dper\GL14655 Dpse\GA20396 Dpse\GA22300
Curated drosophilid orthologs	Dpse\GA20383   Dpse\GA20396
Linkouts	OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • FBgn0233050 FBgn0227056 FBgn0187266 FBgn0177638 FBgn0080391 FBgn0152258 FBgn0110296
Stocks & Reagents
Stocks Listed in FlyBase ( 48 )
Harvard	- P{XP}RhoGAP18Bd01002 - P{XP}RhoGAP18Bd05271 - P{XP}RhoGAP18Bd08872 - PBac{RB}RhoGAP18Be01679 - PBac{RB}RhoGAP18Be02324 - PBac{RB}RhoGAP18Be02346 - PBac{WH}RhoGAP18Bf01190 - PBac{WH}RhoGAP18Bf03742 - PBac{WH}RhoGAP18Bf06094
VDRC	v104589 P{KK110544}VIE-260B v28047 w1118; P{GD12256}v28047 v28039 w1118; P{GD12250}v28039/TM3
	More stocks available...
Genomic Clones ( 1 )
	BACR49A05 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 137 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	LD25711 LP06920
Other clones
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	HL04030 HL07341 LD14570 LD18742 RE02940 RE42510 RE56328 RH07461 RH14057 RH72954 SD02606 SD02607 SD04127 SD07452 SD08603 SD18884 SD23384
Other clones	14324 15070 37120 55431 55998 106066 107586 152917 175466 191674 214315.62 214379.59 214505.58 281211 527204 CK01.41C.F11 CK01.97D.B4 EK050616 EK075738 EK089406 EK097306 EK100462 EK101904 EK112748 EK116659 EK117847 EK120108 EK162951 EK166337 EK182252 EK184046 EK193908 EK194208 EK216012 EK216322 EK217438 EK229560 EK231354 EK233325 EK236220 EK245164 EK248129 EK256257 EK257401 EK264961 EK266071 EK279264 EK281621 EK290810 EK294249 EK306420 EN04723 EN06559 EN07449 EP04927 EP06728 EP06756 EP07928 EP07956 EP08208 EP12048 FGM213A08 RP003021566 RP003044103 RP003045273 RP003056774 RP003072191 RP003083248 RP003089788 RP003114960 RP003117334 RP003119653 RP003121454 RP003122743 RP003126193 RP003134583 RP003146686 RP003162017 RP003163682 RP003164705 RP003178907 RP003192137 RP003225695 RP003234420 RP003260939 RP003263809 RP003277159 RP003297397 RP003317128 RP003321418 RP003329929 RP003355537 RP003382276 RP003392614 RP003427487 RP003440333 RP003443110 RP003480937 RP003501010 RP003503578 RP003504736 RP003518591 RP003519538 RP003526764 RP003539968 RP003544134 RP003544416 RP003561721 RP003572909 RP003589942 RP003607649 RP003613648 RP003624979 RP003634105 RP003661265 RP003668578 RP003671801 RP003682496
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0261461 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 32898 32899
Antibody Information
Other Information
Discoverer
Etymology
	Named 'white rabbit' for its diverse role in regulating responses to abused drugs as described in the song 'White Rabbit' by Jefferson Airplane. (Rothenfluh et al., 2006)
Identification
Relationship to Other Genes
Source for database identity of	Source for identity of: whir 5-131 (Rothenfluh, 2004.2.23)
Source for database merge of	Source for merge of: CG7481 CG7531 (FlyBase, 1996-) Source for merge of: RhoGAP18B CG7502 (FlyBase Genome Annotators, 2008) Source for merge of: RhoGAP18B CG17015 (FlyBase Genome Annotators, 2002-2003) Source for merge of: RhoGAP18B whir (Rothenfluh et al., 2006)
Additional comments	Annotations CG7481 and CG7502 merged as CG42274 in release 5.8 of the genome annotation. (FlyBase Genome Annotators, 2008) Annotations CG7481, CG17015 and CG7531 merged as CG7481 in release 3 of the genome annotation. (FlyBase Genome Annotators, 2002-2003) Source for merge of CG7481 CG7531 was a shared cDNA (date:010720). (FlyBase, 1996-)
Other Comments
	RhoGAP18B is transcribed from at least two promoters separated by approximately 11kb. (Rothenfluh et al., 2006) RhoGAP18B mutants exhibit strong resistance to the sedating effects of ethanol. (Rothenfluh et al., 2006) Mutants show resistance to the behavioral effects of nicotine and altered responses to ethanol. (Rothenfluh et al., 2004) RNAi screen using dsRNA made from templates generated with primers directed against this gene causes a phenotype when assayed in Kc167 and S2R+ cells: increased or polarized (uneven) accumulation of F-actin. (Kiger et al., 2003) dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R+ cell morphology. (Kiger et al., 2003) Mutants are resistant to the behavioral effects of both nicotine and ethanol. Mutants show a strongly accentuated and prolonged startle response, suggesting that they are more sensitive to the sensory input of the alcohol smell, or more responsive to it. (Rothenfluh and Heberlein, 2003)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_133123 NM_133124 NM_001144748 NM_001144749 RefSeq (Proteins) • NP_573351 NP_573352 NP_001138220 NP_001138221 DDBJ / EMBL / GenBank • AA941531 AAF48919 AAF48921 AAL28880 ABF50837 ABF50838 ABF50839 ACL82950 ACL82951 AQ025465 AQ025545 AQ073192 AW942810 AY061332 BH610005 BI356380 CZ471960 CZ472704 CZ474428 CZ475841 CZ476451 CZ476452 CZ476755 CZ476869 CZ480148 CZ480149 CZ480168 CZ483668 CZ486329 CZ486330 CZ488739 DQ486141 DQ486142 DQ486143 Entrez Gene - A searchable database of RefSeq genes. • 32898 UniProtKB/TrEMBL • Q00IM9 Q00IN0 Q9VWL7 Q9VWL9
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Rho GTPase-activating protein domain (IPR000198) Rho GTPase activation protein (IPR008936)
Linkouts
	DroID - A comprehensive database of gene and protein interactions. • FBgn0261461 DRSC - Results from RNAi screens. • FBgn0261461 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0259169 FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0261461 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 32898 32899 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 32898 modMine - Data generated by the modENCODE project. • FBgn0261461 OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • FBgn0233050 FBgn0227056 FBgn0187266 FBgn0177638 FBgn0080391 FBgn0152258 FBgn0110296
Synonyms & Secondary IDs ( 9 )
Reported As
Symbol Synonym	5-131   CG7481 (Billuart et al., 2001, Laviolette et al., 2005) CG7502 (Laviolette et al., 2005, Keleman et al., 2009.8.5) CG7531   CG17015   CG42274 (FlyBase Genome Annotators, 2008, Ni et al., 2008) RhoGAP18B (Rothenfluh et al., 2006, Laviolette et al., 2005, Sordella and Van, 2006, Bakal et al., 2007, Kwon et al., 2008, Zeitlinger et al., 2007, Magalhaes et al., 2007) whir (Rothenfluh et al., 2006, Joseph et al., 2009, Devineni and Heberlein, 2009)
Name Synonym	CG7502   CG42274 (FlyBase Genome Annotators, 2008) RhoGAP18B   white rabbit (Rothenfluh et al., 2004, Joseph et al., 2009, Rothenfluh et al., 2006, Devineni and Heberlein, 2009)
Secondary FlyBase IDs
	FBgn0030986 FBgn0030987 FBgn0030988 FBgn0040888 FBgn0065041 FBgn0259169
References ( 35 )
Generate a list of	All references relating to this gene ( 35 )
List References by type	Research paper  ( 12 ) Supplementary material  ( 5 ) Review  ( 1 ) Personal communication to FlyBase  ( 5 ) Abstract  ( 2 ) FlyBase analysis  ( 5 ) Computer file  ( 3 ) Automatic genome annotation  ( 1 ) Curated genome annotation  ( 1 )
Recent research papers (0)
	All research papers listed in FlyBase were published before 2010 Show research papers ...
Recent reviews (0)
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