• Home
• Tools
  • Tools Overview
  • Query Tools

    
    • QuickSearch
    • QueryBuilder
    • TermLink
    • CytoSearch
    • RNA-Seq Search
    • Interactions Browser
    • ImageBrowse
    • Find A Person
    • Google™ FlyBase
  • Genomic/Map Tools

    
    • BLAST
    • GBrowse
    • GBrowse 2 Beta
    • CytoSearch
    • Feature Mapper
    • Aberrations Maps
    • Chromosome Maps
    • Coordinates Converter
  • Retrieve/Convert

    
    • Batch Download
    • Coordinates Converter
    • ID Converter
  • Data Submission

    
    • Fast-Track Your Paper
    • Submit Personal Comm
    • Add A New Person
    • Update Person Info
  • People

    
    • Find A Person
    • Add A New Person
    • Update Person Info
• Files
  • Files Overview
  • Current release
  • Archived releases
  • Map Conversion
  • FTP site:
  • Releases (FTP)
  • Genomes (FTP)
• Species
  • Phylogeny
  • Sequenced Species
  • Synteny Table
  • Color Illustrations
  • Abbreviations
• Documents
  • About FlyBase
  • Reference Manual:
  • Sections
  • Contents
  • Nomenclature
  • Release Notes
• Resources
  • All Resources
  • Model Organisms
  • Stock Collections
  • Vectors & Constructs
  • Other links:
  • BDGP
  • DGRC
  • DIS by issue
  • FlyExpress
  • Interactive Fly
  • modENCODE
  • Textpresso for Fly
• News
  • News
  • FlyBase Forum
  • FlyBase Positions
  • Meetings
  • Courses
  • Fly Board
  • White papers
  • Funding
  • bionet.dros
• Help
  • Google™ FlyBase
  • Site Map
  • FAQs
  • FlyBase Guides
  • Video Tutorials
  • Report help
  • New to Flies
  • Pers. comm.
  • Author guidelines
  • Contact FlyBase
• Archives
  • Prior Release
  • Other Archives
  • Coordinate Converter

Gene Dmel\RhoGAP18B

General Information
Symbol	Dmel\RhoGAP18B	Species	D. melanogaster
Name	Rho GTPase activating protein at 18B	Annotation symbol	CG42274
Feature type	protein_coding_gene	FlyBase ID	FBgn0261461
Gene Model Status	Current	Stock availability	48 publicly available
Also Known As	CG7481, whir, CG7502
Genomic Location
Chromosome (arm)	X	Recombination map
Cytogenetic map	18A3-18A4	Sequence location	X:19,030,259..19,061,115 [-]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents Beta	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene Rho GTPase activating protein at 18B is referred to in FlyBase by the symbol Dmel\RhoGAP18B (CG42274, FBgn0261461). It is a protein_coding_gene from Drosophila melanogaster. There is experimental evidence that it has the molecular function: GTPase activator activity. There is experimental evidence that it is involved in the biological process: behavioral response to nicotine; behavioral response to ethanol; actin filament organization. 69 alleles are reported. The phenotypes of these alleles are annotated with: trichogen cell; mesothoracic tergum. It has 5 annotated transcripts and 5 annotated polypeptides. Protein features are: Rho GTPase activation protein; Rho GTPase-activating protein domain. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of low expression. Peak expression observed within 06-18 hour embryonic stages. Summary of FlyAtlas Anatomical Expression Data: Two or more Affy2 ProbeSets identify exons of this gene. This is a summary of the tissue expression peaks exhibited in at least one of these ProbeSets. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, adult eye, adult thoracico-abdominal ganglion, adult crop, larval/adult midgut, larval/adult hindgut, adult heart, larval/adult fat body, adult salivary gland, larval trachea. Gene sequence location is X:19030259..19061115.
User Contributed Data
	Beta version, feedback welcome
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
Update Feed	Click the icon below to subscribe to this FlyBase record and receive updates automatically through your feed reader.
FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 18A3-18A4   Limits computationally determined from genome sequence between P{EP}CG7326EP1133 and P{EP}CG7502EP1326
Experimentally Determined Cytological Location
Cytogenetic map Notes References
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\RhoGAP18B for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
	Gene model reviewed during 5.42 Gene model reviewed during 5.49 Gene merge based on EST/cDNA data Low-frequency RNA-Seq exon junction(s) not annotated. Annotated transcripts do not represent all possible combinations of alternative exons and/or alternative promoters. Transposon in 3' UTR.
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) RhoGAP18B-RB FBtr0299622  NM_133123   2208   468 RhoGAP18B-RC FBtr0299623  NM_133124   4576   1317 RhoGAP18B-RD FBtr0299624  NM_001144748   3928   752 RhoGAP18B-RF FBtr0299625  NM_001144749   1689   468 RhoGAP18B-RH FBtr0339261     1787   468
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein RhoGAP18B-PB   FBpp0288897   52.2   468   8.27     NP_573351   AAF48919 RhoGAP18B-PC   FBpp0288898   147.3   1317   6.87     NP_573352   AAF48921 RhoGAP18B-PD   FBpp0288899   84.5   752   4.85     NP_001138220   ACL82950 RhoGAP18B-PF   FBpp0288900   52.2   468   8.27     NP_001138221   ACL82951 RhoGAP18B-PH   FBpp0308368   52.2   468   8.27
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Rho GTPase-activating protein domain (IPR000198) Rho GTPase activation protein (IPR008936)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA439889   AA539040   AA698251   AA699035   AA941531   AE014298 AAF48919   AE014298 AAF48921   AE014298 ACL82950   AE014298 ACL82951   AI531523   AI531524   AI532572   AI542316   AQ025465   AQ025545   AQ073192   AW942810   AY061332 AAL28880   BG639842   BH610005   BI163520   BI356380   BI369973   BI572109   BI606465   BI609295   BI637008   BI640502   BP551468   BT099667   CO154748   CO155692   CO156160   CO191067   CO263721   CO270067   CO270841   CO271069   CO273964   CO275179   CO275535   CO276233   CO283373   CO284580   CO290993   CO297107   CO297185   CO301827   CO302390   CO304574   CO305304   CO307956   CO308284   CO309370   CO312648   CO313100   CO313538   CO314432   CO316446   CO316874   CO319596   CO319973   CO321322   CO324467   CO324545   CO326895   CO327292   CO327318   CO327723   CO327751   CO327880   CO329965   CO333294   CO341217   CZ471960   CZ472704   CZ474428   CZ475841   CZ476451   CZ476452   CZ476755   CZ476869   CZ480148   CZ480149   CZ480168   CZ483668   CZ486329   CZ486330   CZ488739   DQ486141 ABF50837   DQ486142 ABF50838   DQ486143 ABF50839   EC065156   EC067417   EC072176   EC085486   EC085533   EC089911   EC195212   EC205357   EC209516   EC210495   EC214037   EC238133   EC242346   EC254052   EC258003   EC260153   EC265763   GH749150   GH751493   GH751815   GH753239   GH770221   GH772129   GH772890   GH774333   GH776541   GH778893   GH783887   GH788945   GH791097   GH793651   GH798646   GH799657   GH812145   GH813794   GH815869   GH816673   GH820192   GH820883   GH824402   GH827981   GH830067   GH832629   GH838341   GH838412   GH848490   GH849309   GH851124   GH856429   GH858477   GH870375   GH872926   GH874223   GH874309   GH882150   GH887764   GH892095   GH893003   GH897050   GH899866   GH901403   GH906697   GH906926   GH909979   GH928774   GH931360   GH933692   GH934006   GH934537   GH936238   GH937947   GH940097   GH940880
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL	Q9VWL9 Q00IN0 Q9VWL7 Q00IM9
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
in situ Stage Tissue/Position (including subcellular localization) Reference embryonic stage 1 -- 3   organism   (Fisher et al., 2012) Comment:maternally deposited embryonic stage 4 -- 6   organism   (Fisher et al., 2012) embryonic stage 11 -- 12   dorsal epidermis primordium   (Fisher et al., 2012) dorsal head epidermis primordium   (Fisher et al., 2012) Comment:reported as head epidermis primordium lateral head epidermis primordium   (Fisher et al., 2012) Comment:reported as head epidermis primordium ventral head epidermis primordium   (Fisher et al., 2012) Comment:reported as head epidermis primordium ventral epidermis primordium   (Fisher et al., 2012) embryonic stage 13 -- 16   embryonic dorsal epidermis   (Fisher et al., 2012) embryonic head epidermis   (Fisher et al., 2012) embryonic ventral epidermis   (Fisher et al., 2012)
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Polypeptide Expression
Additional Descriptive Data
Marker for
Subcellular Localization (GO Cellular Component)
CV term Evidence References
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools
Reference	See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes.
FlyAtlas Anatomy Microarray
FlyAtlas Anatomical Expression Data (FlyAtlas-RNA.adult) (FlyAtlas-RNA.larva)    Styles Linear Logarithmic Heatmap Back-to-back    Scales gene max expression Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Two or more Affy2 ProbeSets identify exons of this gene. This is a summary of the tissue expression peaks exhibited in at least one of these ProbeSets. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, adult eye, adult thoracico-abdominal ganglion, adult crop, larval/adult midgut, larval/adult hindgut, adult heart, larval/adult fat body, adult salivary gland, larval trachea. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (>999.999) Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
modENCODE Anatomy RNA-Seq
modENCODE Tissue Expression Data (modENCODE_mRNA-Seq_tissues)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    5 central nervous system, larvae L3    6 central nervous system, pupae P8    4 head, virgin 1-day female    7 head, virgin 4-day female    7 head, virgin 20-day female    6 head, mated 1-day female    7 head, mated 4-day female    6 head, mated 20-day female    6 head, mated 1-day male    9 head, mated 4-day male    8 head, mated 20-day male    8 salivary gland, larvae L3 wandering    1 salivary gland, white prepupae    3 digestive system, larvae L3 wandering    11 digestive system, 1-day adult    5 digestive system, 4-day adult    7 digestive system, 20-day adult    9 fat body, larvae L3 wandering    8 fat body, white prepupae    9 fat body, pupae P8    8 carcass, larvae L3 wandering    6 carcass, 1-day adult    5 carcass, 4-day adult    5 carcass, 20-day adult    6 ovary, virgin 4-day female    8 ovary, mated 4-day female    10 testis, mated 4-day male    1 accessory gland, mated 4-day male    1 Expression Level Scale  Very low   Low   Moderate  Linear, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering    5 central nervous system, larvae L3    6 central nervous system, pupae P8    4 head, virgin 1-day female    7 head, virgin 4-day female    7 head, virgin 20-day female    6 head, mated 1-day female    7 head, mated 4-day female    6 head, mated 20-day female    6 head, mated 1-day male    9 head, mated 4-day male    8 head, mated 20-day male    8 salivary gland, larvae L3 wandering    1 salivary gland, white prepupae    3 digestive system, larvae L3 wandering    11 digestive system, 1-day adult    5 digestive system, 4-day adult    7 digestive system, 20-day adult    9 fat body, larvae L3 wandering    8 fat body, white prepupae    9 fat body, pupae P8    8 carcass, larvae L3 wandering    6 carcass, 1-day adult    5 carcass, 4-day adult    5 carcass, 20-day adult    6 ovary, virgin 4-day female    8 ovary, mated 4-day female    10 testis, mated 4-day male    1 accessory gland, mated 4-day male    1 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    5 central nervous system, larvae L3    6 central nervous system, pupae P8    4 head, virgin 1-day female    7 head, virgin 4-day female    7 head, virgin 20-day female    6 head, mated 1-day female    7 head, mated 4-day female    6 head, mated 20-day female    6 head, mated 1-day male    9 head, mated 4-day male    8 head, mated 20-day male    8 salivary gland, larvae L3 wandering    1 salivary gland, white prepupae    3 digestive system, larvae L3 wandering    11 digestive system, 1-day adult    5 digestive system, 4-day adult    7 digestive system, 20-day adult    9 fat body, larvae L3 wandering    8 fat body, white prepupae    9 fat body, pupae P8    8 carcass, larvae L3 wandering    6 carcass, 1-day adult    5 carcass, 4-day adult    5 carcass, 20-day adult    6 ovary, virgin 4-day female    8 ovary, mated 4-day female    10 testis, mated 4-day male    1 accessory gland, mated 4-day male    1 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    5 central nervous system, larvae L3    6 central nervous system, pupae P8    4 head, virgin 1-day female    7 head, virgin 4-day female    7 head, virgin 20-day female    6 head, mated 1-day female    7 head, mated 4-day female    6 head, mated 20-day female    6 head, mated 1-day male    9 head, mated 4-day male    8 head, mated 20-day male    8 salivary gland, larvae L3 wandering    1 salivary gland, white prepupae    3 digestive system, larvae L3 wandering    11 digestive system, 1-day adult    5 digestive system, 4-day adult    7 digestive system, 20-day adult    9 fat body, larvae L3 wandering    8 fat body, white prepupae    9 fat body, pupae P8    8 carcass, larvae L3 wandering    6 carcass, 1-day adult    5 carcass, 4-day adult    5 carcass, 20-day adult    6 ovary, virgin 4-day female    8 ovary, mated 4-day female    10 testis, mated 4-day male    1 accessory gland, mated 4-day male    1 Expression Level Scale  Extremely high  log, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    5 central nervous system, larvae L3    6 central nervous system, pupae P8    4 head, virgin 1-day female    7 head, virgin 4-day female    7 head, virgin 20-day female    6 head, mated 1-day female    7 head, mated 4-day female    6 head, mated 20-day female    6 head, mated 1-day male    9 head, mated 4-day male    8 head, mated 20-day male    8 salivary gland, larvae L3 wandering    1 salivary gland, white prepupae    3 digestive system, larvae L3 wandering    11 digestive system, 1-day adult    5 digestive system, 4-day adult    7 digestive system, 20-day adult    9 fat body, larvae L3 wandering    8 fat body, white prepupae    9 fat body, pupae P8    8 carcass, larvae L3 wandering    6 carcass, 1-day adult    5 carcass, 4-day adult    5 carcass, 20-day adult    6 ovary, virgin 4-day female    8 ovary, mated 4-day female    10 testis, mated 4-day male    1 accessory gland, mated 4-day male    1 Expression Level Scale  Very low   Low   Moderate  log, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering    5 central nervous system, larvae L3    6 central nervous system, pupae P8    4 head, virgin 1-day female    7 head, virgin 4-day female    7 head, virgin 20-day female    6 head, mated 1-day female    7 head, mated 4-day female    6 head, mated 20-day female    6 head, mated 1-day male    9 head, mated 4-day male    8 head, mated 20-day male    8 salivary gland, larvae L3 wandering    1 salivary gland, white prepupae    3 digestive system, larvae L3 wandering    11 digestive system, 1-day adult    5 digestive system, 4-day adult    7 digestive system, 20-day adult    9 fat body, larvae L3 wandering    8 fat body, white prepupae    9 fat body, pupae P8    8 carcass, larvae L3 wandering    6 carcass, 1-day adult    5 carcass, 4-day adult    5 carcass, 20-day adult    6 ovary, virgin 4-day female    8 ovary, mated 4-day female    10 testis, mated 4-day male    1 accessory gland, mated 4-day male    1 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    5 central nervous system, larvae L3    6 central nervous system, pupae P8    4 head, virgin 1-day female    7 head, virgin 4-day female    7 head, virgin 20-day female    6 head, mated 1-day female    7 head, mated 4-day female    6 head, mated 20-day female    6 head, mated 1-day male    9 head, mated 4-day male    8 head, mated 20-day male    8 salivary gland, larvae L3 wandering    1 salivary gland, white prepupae    3 digestive system, larvae L3 wandering    11 digestive system, 1-day adult    5 digestive system, 4-day adult    7 digestive system, 20-day adult    9 fat body, larvae L3 wandering    8 fat body, white prepupae    9 fat body, pupae P8    8 carcass, larvae L3 wandering    6 carcass, 1-day adult    5 carcass, 4-day adult    5 carcass, 20-day adult    6 ovary, virgin 4-day female    8 ovary, mated 4-day female    10 testis, mated 4-day male    1 accessory gland, mated 4-day male    1 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    5 central nervous system, larvae L3    6 central nervous system, pupae P8    4 head, virgin 1-day female    7 head, virgin 4-day female    7 head, virgin 20-day female    6 head, mated 1-day female    7 head, mated 4-day female    6 head, mated 20-day female    6 head, mated 1-day male    9 head, mated 4-day male    8 head, mated 20-day male    8 salivary gland, larvae L3 wandering    1 salivary gland, white prepupae    3 digestive system, larvae L3 wandering    11 digestive system, 1-day adult    5 digestive system, 4-day adult    7 digestive system, 20-day adult    9 fat body, larvae L3 wandering    8 fat body, white prepupae    9 fat body, pupae P8    8 carcass, larvae L3 wandering    6 carcass, 1-day adult    5 carcass, 4-day adult    5 carcass, 20-day adult    6 ovary, virgin 4-day female    8 ovary, mated 4-day female    10 testis, mated 4-day male    1 accessory gland, mated 4-day male    1 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Tissue   Expression Level imaginal disc, larvae L3 wandering     central nervous system, larvae L3     central nervous system, pupae P8     head, virgin 1-day female     head, virgin 4-day female     head, virgin 20-day female     head, mated 1-day female     head, mated 4-day female     head, mated 20-day female     head, mated 1-day male     head, mated 4-day male     head, mated 20-day male     salivary gland, larvae L3 wandering     salivary gland, white prepupae     digestive system, larvae L3 wandering     digestive system, 1-day adult     digestive system, 4-day adult     digestive system, 20-day adult     fat body, larvae L3 wandering     fat body, white prepupae     fat body, pupae P8     carcass, larvae L3 wandering     carcass, 1-day adult     carcass, 4-day adult     carcass, 20-day adult     ovary, virgin 4-day female     ovary, mated 4-day female     testis, mated 4-day male     accessory gland, mated 4-day male
modENCODE Development RNA-Seq
modENCODE Temporal Expression Data (modENCODE_mRNA-Seq_U)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of low expression. Peak expression observed within 06-18 hour embryonic stages. [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    9 embryo 02-04hr    5 embryo 04-06hr    4 embryo 06-08hr    11 embryo 08-10hr    16 embryo 10-12hr    18 embryo 12-14hr    12 embryo 14-16hr    23 embryo 16-18hr    16 embryo 18-20hr    14 embryo 20-22hr    11 embryo 22-24hr    12 larva L1    5 larva L2    5 larva L3 12hr old    4 larva L3 puffstage 1-2    4 larva L3 puffstage 3-6    8 larva L3 puffstage 7-9    10 white prepupae new    12 white prepupae 12hr    10 white prepupae 24hr    9 pupae 2d postWPP    6 pupae 3d postWPP    4 pupae 4d postWPP    9 adult male 01day    5 adult male 05day    5 adult male 30day    6 adult female 01day    6 adult female 05day    5 adult female 30day    6 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    9 embryo 02-04hr    5 embryo 04-06hr    4 embryo 06-08hr    11 embryo 08-10hr    16 embryo 10-12hr    18 embryo 12-14hr    12 embryo 14-16hr    23 embryo 16-18hr    16 embryo 18-20hr    14 embryo 20-22hr    11 embryo 22-24hr    12 larva L1    5 larva L2    5 larva L3 12hr old    4 larva L3 puffstage 1-2    4 larva L3 puffstage 3-6    8 larva L3 puffstage 7-9    10 white prepupae new    12 white prepupae 12hr    10 white prepupae 24hr    9 pupae 2d postWPP    6 pupae 3d postWPP    4 pupae 4d postWPP    9 adult male 01day    5 adult male 05day    5 adult male 30day    6 adult female 01day    6 adult female 05day    5 adult female 30day    6 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    9 embryo 02-04hr    5 embryo 04-06hr    4 embryo 06-08hr    11 embryo 08-10hr    16 embryo 10-12hr    18 embryo 12-14hr    12 embryo 14-16hr    23 embryo 16-18hr    16 embryo 18-20hr    14 embryo 20-22hr    11 embryo 22-24hr    12 larva L1    5 larva L2    5 larva L3 12hr old    4 larva L3 puffstage 1-2    4 larva L3 puffstage 3-6    8 larva L3 puffstage 7-9    10 white prepupae new    12 white prepupae 12hr    10 white prepupae 24hr    9 pupae 2d postWPP    6 pupae 3d postWPP    4 pupae 4d postWPP    9 adult male 01day    5 adult male 05day    5 adult male 30day    6 adult female 01day    6 adult female 05day    5 adult female 30day    6 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    9 embryo 02-04hr    5 embryo 04-06hr    4 embryo 06-08hr    11 embryo 08-10hr    16 embryo 10-12hr    18 embryo 12-14hr    12 embryo 14-16hr    23 embryo 16-18hr    16 embryo 18-20hr    14 embryo 20-22hr    11 embryo 22-24hr    12 larva L1    5 larva L2    5 larva L3 12hr old    4 larva L3 puffstage 1-2    4 larva L3 puffstage 3-6    8 larva L3 puffstage 7-9    10 white prepupae new    12 white prepupae 12hr    10 white prepupae 24hr    9 pupae 2d postWPP    6 pupae 3d postWPP    4 pupae 4d postWPP    9 adult male 01day    5 adult male 05day    5 adult male 30day    6 adult female 01day    6 adult female 05day    5 adult female 30day    6 Expression Level Scale  Extremely high  log, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    9 embryo 02-04hr    5 embryo 04-06hr    4 embryo 06-08hr    11 embryo 08-10hr    16 embryo 10-12hr    18 embryo 12-14hr    12 embryo 14-16hr    23 embryo 16-18hr    16 embryo 18-20hr    14 embryo 20-22hr    11 embryo 22-24hr    12 larva L1    5 larva L2    5 larva L3 12hr old    4 larva L3 puffstage 1-2    4 larva L3 puffstage 3-6    8 larva L3 puffstage 7-9    10 white prepupae new    12 white prepupae 12hr    10 white prepupae 24hr    9 pupae 2d postWPP    6 pupae 3d postWPP    4 pupae 4d postWPP    9 adult male 01day    5 adult male 05day    5 adult male 30day    6 adult female 01day    6 adult female 05day    5 adult female 30day    6 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    9 embryo 02-04hr    5 embryo 04-06hr    4 embryo 06-08hr    11 embryo 08-10hr    16 embryo 10-12hr    18 embryo 12-14hr    12 embryo 14-16hr    23 embryo 16-18hr    16 embryo 18-20hr    14 embryo 20-22hr    11 embryo 22-24hr    12 larva L1    5 larva L2    5 larva L3 12hr old    4 larva L3 puffstage 1-2    4 larva L3 puffstage 3-6    8 larva L3 puffstage 7-9    10 white prepupae new    12 white prepupae 12hr    10 white prepupae 24hr    9 pupae 2d postWPP    6 pupae 3d postWPP    4 pupae 4d postWPP    9 adult male 01day    5 adult male 05day    5 adult male 30day    6 adult female 01day    6 adult female 05day    5 adult female 30day    6 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    9 embryo 02-04hr    5 embryo 04-06hr    4 embryo 06-08hr    11 embryo 08-10hr    16 embryo 10-12hr    18 embryo 12-14hr    12 embryo 14-16hr    23 embryo 16-18hr    16 embryo 18-20hr    14 embryo 20-22hr    11 embryo 22-24hr    12 larva L1    5 larva L2    5 larva L3 12hr old    4 larva L3 puffstage 1-2    4 larva L3 puffstage 3-6    8 larva L3 puffstage 7-9    10 white prepupae new    12 white prepupae 12hr    10 white prepupae 24hr    9 pupae 2d postWPP    6 pupae 3d postWPP    4 pupae 4d postWPP    9 adult male 01day    5 adult male 05day    5 adult male 30day    6 adult female 01day    6 adult female 05day    5 adult female 30day    6 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    9 embryo 02-04hr    5 embryo 04-06hr    4 embryo 06-08hr    11 embryo 08-10hr    16 embryo 10-12hr    18 embryo 12-14hr    12 embryo 14-16hr    23 embryo 16-18hr    16 embryo 18-20hr    14 embryo 20-22hr    11 embryo 22-24hr    12 larva L1    5 larva L2    5 larva L3 12hr old    4 larva L3 puffstage 1-2    4 larva L3 puffstage 3-6    8 larva L3 puffstage 7-9    10 white prepupae new    12 white prepupae 12hr    10 white prepupae 24hr    9 pupae 2d postWPP    6 pupae 3d postWPP    4 pupae 4d postWPP    9 adult male 01day    5 adult male 05day    5 adult male 30day    6 adult female 01day    6 adult female 05day    5 adult female 30day    6 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     modENCODE Temporal Expression Data (Graveley et al., 2011)
modENCODE Cell Lines RNA-Seq
modENCODE Cell Line Expression Data (modENCODE_mRNA-Seq_cell.A) (modENCODE_mRNA-Seq_cell.B)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    114 Schneider line 2 Sg4    15 embryonic 1182-4H    18 embryonic GM2    20 embryonic Kc167    20 embryonic S1    7 embryonic S3    9 leg disc CME L1    17 wing disc CME-W2    9 wing disc ML-DmD8    27 wing disc ML-DmD9    15 wing disc ML-DmD16-c3    23 wing disc ML-DmD21    45 wing disc ML-DmD32    23 haltere disc ML-DmD17-c3    42 eye-antennal disc ML-DmD11    20 antennal disc ML-DmD20-c5    6 mixed discs ML-DmD4-c1    40 CNS ML-DmBG1-c1    48 CNS ML-DmBG2-c2    18 tumorous blood cells mbn2    11 ovary fGS/OSS    32 ovary OSC    18 ovary OSS    7 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+  (114) Schneider line 2 Sg4    15 embryonic 1182-4H    18 embryonic GM2    20 embryonic Kc167    20 embryonic S1    7 embryonic S3    9 leg disc CME L1    17 wing disc CME-W2    9 wing disc ML-DmD8  (27) wing disc ML-DmD9    15 wing disc ML-DmD16-c3    23 wing disc ML-DmD21  (45) wing disc ML-DmD32    23 haltere disc ML-DmD17-c3  (42) eye-antennal disc ML-DmD11    20 antennal disc ML-DmD20-c5    6 mixed discs ML-DmD4-c1  (40) CNS ML-DmBG1-c1  (48) CNS ML-DmBG2-c2    18 tumorous blood cells mbn2    11 ovary fGS/OSS  (32) ovary OSC    18 ovary OSS    7 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+  (114) Schneider line 2 Sg4    15 embryonic 1182-4H    18 embryonic GM2    20 embryonic Kc167    20 embryonic S1    7 embryonic S3    9 leg disc CME L1    17 wing disc CME-W2    9 wing disc ML-DmD8    27 wing disc ML-DmD9    15 wing disc ML-DmD16-c3    23 wing disc ML-DmD21    45 wing disc ML-DmD32    23 haltere disc ML-DmD17-c3    42 eye-antennal disc ML-DmD11    20 antennal disc ML-DmD20-c5    6 mixed discs ML-DmD4-c1    40 CNS ML-DmBG1-c1    48 CNS ML-DmBG2-c2    18 tumorous blood cells mbn2    11 ovary fGS/OSS    32 ovary OSC    18 ovary OSS    7 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    114 Schneider line 2 Sg4    15 embryonic 1182-4H    18 embryonic GM2    20 embryonic Kc167    20 embryonic S1    7 embryonic S3    9 leg disc CME L1    17 wing disc CME-W2    9 wing disc ML-DmD8    27 wing disc ML-DmD9    15 wing disc ML-DmD16-c3    23 wing disc ML-DmD21    45 wing disc ML-DmD32    23 haltere disc ML-DmD17-c3    42 eye-antennal disc ML-DmD11    20 antennal disc ML-DmD20-c5    6 mixed discs ML-DmD4-c1    40 CNS ML-DmBG1-c1    48 CNS ML-DmBG2-c2    18 tumorous blood cells mbn2    11 ovary fGS/OSS    32 ovary OSC    18 ovary OSS    7 Expression Level Scale  Extremely high  log, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    114 Schneider line 2 Sg4    15 embryonic 1182-4H    18 embryonic GM2    20 embryonic Kc167    20 embryonic S1    7 embryonic S3    9 leg disc CME L1    17 wing disc CME-W2    9 wing disc ML-DmD8    27 wing disc ML-DmD9    15 wing disc ML-DmD16-c3    23 wing disc ML-DmD21    45 wing disc ML-DmD32    23 haltere disc ML-DmD17-c3    42 eye-antennal disc ML-DmD11    20 antennal disc ML-DmD20-c5    6 mixed discs ML-DmD4-c1    40 CNS ML-DmBG1-c1    48 CNS ML-DmBG2-c2    18 tumorous blood cells mbn2    11 ovary fGS/OSS    32 ovary OSC    18 ovary OSS    7 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+  (114) Schneider line 2 Sg4    15 embryonic 1182-4H    18 embryonic GM2    20 embryonic Kc167    20 embryonic S1    7 embryonic S3    9 leg disc CME L1    17 wing disc CME-W2    9 wing disc ML-DmD8  27 wing disc ML-DmD9    15 wing disc ML-DmD16-c3    23 wing disc ML-DmD21  (45) wing disc ML-DmD32    23 haltere disc ML-DmD17-c3  (42) eye-antennal disc ML-DmD11    20 antennal disc ML-DmD20-c5    6 mixed discs ML-DmD4-c1  (40) CNS ML-DmBG1-c1  (48) CNS ML-DmBG2-c2    18 tumorous blood cells mbn2    11 ovary fGS/OSS  32 ovary OSC    18 ovary OSS    7 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+  114 Schneider line 2 Sg4    15 embryonic 1182-4H    18 embryonic GM2    20 embryonic Kc167    20 embryonic S1    7 embryonic S3    9 leg disc CME L1    17 wing disc CME-W2    9 wing disc ML-DmD8    27 wing disc ML-DmD9    15 wing disc ML-DmD16-c3    23 wing disc ML-DmD21    45 wing disc ML-DmD32    23 haltere disc ML-DmD17-c3    42 eye-antennal disc ML-DmD11    20 antennal disc ML-DmD20-c5    6 mixed discs ML-DmD4-c1    40 CNS ML-DmBG1-c1    48 CNS ML-DmBG2-c2    18 tumorous blood cells mbn2    11 ovary fGS/OSS    32 ovary OSC    18 ovary OSS    7 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    114 Schneider line 2 Sg4    15 embryonic 1182-4H    18 embryonic GM2    20 embryonic Kc167    20 embryonic S1    7 embryonic S3    9 leg disc CME L1    17 wing disc CME-W2    9 wing disc ML-DmD8    27 wing disc ML-DmD9    15 wing disc ML-DmD16-c3    23 wing disc ML-DmD21    45 wing disc ML-DmD32    23 haltere disc ML-DmD17-c3    42 eye-antennal disc ML-DmD11    20 antennal disc ML-DmD20-c5    6 mixed discs ML-DmD4-c1    40 CNS ML-DmBG1-c1    48 CNS ML-DmBG2-c2    18 tumorous blood cells mbn2    11 ovary fGS/OSS    32 ovary OSC    18 ovary OSS    7 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Cell Line   Expression Level Schneider line 2 S2R+     Schneider line 2 Sg4     embryonic 1182-4H     embryonic GM2     embryonic Kc167     embryonic S1     embryonic S3     leg disc CME L1     wing disc CME-W2     wing disc ML-DmD8     wing disc ML-DmD9     wing disc ML-DmD16-c3     wing disc ML-DmD21     wing disc ML-DmD32     haltere disc ML-DmD17-c3     eye-antennal disc ML-DmD11     antennal disc ML-DmD20-c5     mixed discs ML-DmD4-c1     CNS ML-DmBG1-c1     CNS ML-DmBG2-c2     tumorous blood cells mbn2     ovary fGS/OSS     ovary OSC     ovary OSS
modENCODE Treatments RNA-Seq
modENCODE Treatment Expression Data (modENCODE_mRNA-Seq_treatments)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    7 cold shock, 4-day adult    6 heat shock, 4-day adult    5 Cadmium 50 mM 6 hrs, larvae L3    4 Cadmium 50 mM 12 hrs, larvae L3    3 Cadmium 50 mM 48 hrs, 4-day adult    6 Cadmium 100 mM 48 hrs, 4-day adult    13 Copper 0.5 mM 12 hrs, larvae L3    5 Copper 15 mM 48 hrs, 4-day adult    8 Zinc 5 mM 12 hrs, larvae L3    4 Zinc 4.5 mM 48 hrs, 4-day adult    8 Ethanol 2.5% 3 hrs, larvae L3    12 Ethanol 5% 3 hrs, larvae L3    5 Ethanol 10% 3 hrs, larvae L3    4 Caffeine 1.5 mg/ml 4 hrs, larvae L3    4 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    10 Caffeine 25 mg/ml 48 hrs, 4-day adult    9 Paraquat 5 mM 48 hrs, 4-day adult    9 Paraquat 10 mM 48 hrs, 4-day adult    10 Rotenone 2 μg 12 hrs, larvae L3    3 Rotenone 8 μg 12 hrs, larvae L3    3 Expression Level Scale  Very low   Low   Moderate  Linear, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult    7 cold shock, 4-day adult    6 heat shock, 4-day adult    5 Cadmium 50 mM 6 hrs, larvae L3    4 Cadmium 50 mM 12 hrs, larvae L3    3 Cadmium 50 mM 48 hrs, 4-day adult    6 Cadmium 100 mM 48 hrs, 4-day adult    13 Copper 0.5 mM 12 hrs, larvae L3    5 Copper 15 mM 48 hrs, 4-day adult    8 Zinc 5 mM 12 hrs, larvae L3    4 Zinc 4.5 mM 48 hrs, 4-day adult    8 Ethanol 2.5% 3 hrs, larvae L3    12 Ethanol 5% 3 hrs, larvae L3    5 Ethanol 10% 3 hrs, larvae L3    4 Caffeine 1.5 mg/ml 4 hrs, larvae L3    4 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    10 Caffeine 25 mg/ml 48 hrs, 4-day adult    9 Paraquat 5 mM 48 hrs, 4-day adult    9 Paraquat 10 mM 48 hrs, 4-day adult    10 Rotenone 2 μg 12 hrs, larvae L3    3 Rotenone 8 μg 12 hrs, larvae L3    3 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    7 cold shock, 4-day adult    6 heat shock, 4-day adult    5 Cadmium 50 mM 6 hrs, larvae L3    4 Cadmium 50 mM 12 hrs, larvae L3    3 Cadmium 50 mM 48 hrs, 4-day adult    6 Cadmium 100 mM 48 hrs, 4-day adult    13 Copper 0.5 mM 12 hrs, larvae L3    5 Copper 15 mM 48 hrs, 4-day adult    8 Zinc 5 mM 12 hrs, larvae L3    4 Zinc 4.5 mM 48 hrs, 4-day adult    8 Ethanol 2.5% 3 hrs, larvae L3    12 Ethanol 5% 3 hrs, larvae L3    5 Ethanol 10% 3 hrs, larvae L3    4 Caffeine 1.5 mg/ml 4 hrs, larvae L3    4 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    10 Caffeine 25 mg/ml 48 hrs, 4-day adult    9 Paraquat 5 mM 48 hrs, 4-day adult    9 Paraquat 10 mM 48 hrs, 4-day adult    10 Rotenone 2 μg 12 hrs, larvae L3    3 Rotenone 8 μg 12 hrs, larvae L3    3 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    7 cold shock, 4-day adult    6 heat shock, 4-day adult    5 Cadmium 50 mM 6 hrs, larvae L3    4 Cadmium 50 mM 12 hrs, larvae L3    3 Cadmium 50 mM 48 hrs, 4-day adult    6 Cadmium 100 mM 48 hrs, 4-day adult    13 Copper 0.5 mM 12 hrs, larvae L3    5 Copper 15 mM 48 hrs, 4-day adult    8 Zinc 5 mM 12 hrs, larvae L3    4 Zinc 4.5 mM 48 hrs, 4-day adult    8 Ethanol 2.5% 3 hrs, larvae L3    12 Ethanol 5% 3 hrs, larvae L3    5 Ethanol 10% 3 hrs, larvae L3    4 Caffeine 1.5 mg/ml 4 hrs, larvae L3    4 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    10 Caffeine 25 mg/ml 48 hrs, 4-day adult    9 Paraquat 5 mM 48 hrs, 4-day adult    9 Paraquat 10 mM 48 hrs, 4-day adult    10 Rotenone 2 μg 12 hrs, larvae L3    3 Rotenone 8 μg 12 hrs, larvae L3    3 Expression Level Scale  Extremely high  log, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    7 cold shock, 4-day adult    6 heat shock, 4-day adult    5 Cadmium 50 mM 6 hrs, larvae L3    4 Cadmium 50 mM 12 hrs, larvae L3    3 Cadmium 50 mM 48 hrs, 4-day adult    6 Cadmium 100 mM 48 hrs, 4-day adult    13 Copper 0.5 mM 12 hrs, larvae L3    5 Copper 15 mM 48 hrs, 4-day adult    8 Zinc 5 mM 12 hrs, larvae L3    4 Zinc 4.5 mM 48 hrs, 4-day adult    8 Ethanol 2.5% 3 hrs, larvae L3    12 Ethanol 5% 3 hrs, larvae L3    5 Ethanol 10% 3 hrs, larvae L3    4 Caffeine 1.5 mg/ml 4 hrs, larvae L3    4 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    10 Caffeine 25 mg/ml 48 hrs, 4-day adult    9 Paraquat 5 mM 48 hrs, 4-day adult    9 Paraquat 10 mM 48 hrs, 4-day adult    10 Rotenone 2 μg 12 hrs, larvae L3    3 Rotenone 8 μg 12 hrs, larvae L3    3 Expression Level Scale  Very low   Low   Moderate  log, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult    7 cold shock, 4-day adult    6 heat shock, 4-day adult    5 Cadmium 50 mM 6 hrs, larvae L3    4 Cadmium 50 mM 12 hrs, larvae L3    3 Cadmium 50 mM 48 hrs, 4-day adult    6 Cadmium 100 mM 48 hrs, 4-day adult    13 Copper 0.5 mM 12 hrs, larvae L3    5 Copper 15 mM 48 hrs, 4-day adult    8 Zinc 5 mM 12 hrs, larvae L3    4 Zinc 4.5 mM 48 hrs, 4-day adult    8 Ethanol 2.5% 3 hrs, larvae L3    12 Ethanol 5% 3 hrs, larvae L3    5 Ethanol 10% 3 hrs, larvae L3    4 Caffeine 1.5 mg/ml 4 hrs, larvae L3    4 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    10 Caffeine 25 mg/ml 48 hrs, 4-day adult    9 Paraquat 5 mM 48 hrs, 4-day adult    9 Paraquat 10 mM 48 hrs, 4-day adult    10 Rotenone 2 μg 12 hrs, larvae L3    3 Rotenone 8 μg 12 hrs, larvae L3    3 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    7 cold shock, 4-day adult    6 heat shock, 4-day adult    5 Cadmium 50 mM 6 hrs, larvae L3    4 Cadmium 50 mM 12 hrs, larvae L3    3 Cadmium 50 mM 48 hrs, 4-day adult    6 Cadmium 100 mM 48 hrs, 4-day adult    13 Copper 0.5 mM 12 hrs, larvae L3    5 Copper 15 mM 48 hrs, 4-day adult    8 Zinc 5 mM 12 hrs, larvae L3    4 Zinc 4.5 mM 48 hrs, 4-day adult    8 Ethanol 2.5% 3 hrs, larvae L3    12 Ethanol 5% 3 hrs, larvae L3    5 Ethanol 10% 3 hrs, larvae L3    4 Caffeine 1.5 mg/ml 4 hrs, larvae L3    4 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    10 Caffeine 25 mg/ml 48 hrs, 4-day adult    9 Paraquat 5 mM 48 hrs, 4-day adult    9 Paraquat 10 mM 48 hrs, 4-day adult    10 Rotenone 2 μg 12 hrs, larvae L3    3 Rotenone 8 μg 12 hrs, larvae L3    3 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    7 cold shock, 4-day adult    6 heat shock, 4-day adult    5 Cadmium 50 mM 6 hrs, larvae L3    4 Cadmium 50 mM 12 hrs, larvae L3    3 Cadmium 50 mM 48 hrs, 4-day adult    6 Cadmium 100 mM 48 hrs, 4-day adult    13 Copper 0.5 mM 12 hrs, larvae L3    5 Copper 15 mM 48 hrs, 4-day adult    8 Zinc 5 mM 12 hrs, larvae L3    4 Zinc 4.5 mM 48 hrs, 4-day adult    8 Ethanol 2.5% 3 hrs, larvae L3    12 Ethanol 5% 3 hrs, larvae L3    5 Ethanol 10% 3 hrs, larvae L3    4 Caffeine 1.5 mg/ml 4 hrs, larvae L3    4 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    10 Caffeine 25 mg/ml 48 hrs, 4-day adult    9 Paraquat 5 mM 48 hrs, 4-day adult    9 Paraquat 10 mM 48 hrs, 4-day adult    10 Rotenone 2 μg 12 hrs, larvae L3    3 Rotenone 8 μg 12 hrs, larvae L3    3 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Treatment   Expression Level extended cold, 4-day adult     cold shock, 4-day adult     heat shock, 4-day adult     Cadmium 50 mM 6 hrs, larvae L3     Cadmium 50 mM 12 hrs, larvae L3     Cadmium 50 mM 48 hrs, 4-day adult     Cadmium 100 mM 48 hrs, 4-day adult     Copper 0.5 mM 12 hrs, larvae L3     Copper 15 mM 48 hrs, 4-day adult     Zinc 5 mM 12 hrs, larvae L3     Zinc 4.5 mM 48 hrs, 4-day adult     Ethanol 2.5% 3 hrs, larvae L3     Ethanol 5% 3 hrs, larvae L3     Ethanol 10% 3 hrs, larvae L3     Caffeine 1.5 mg/ml 4 hrs, larvae L3     Caffeine 2.5 mg/ml 48 hrs, 4-day adult     Caffeine 25 mg/ml 48 hrs, 4-day adult     Paraquat 5 mM 48 hrs, 4-day adult     Paraquat 10 mM 48 hrs, 4-day adult     Rotenone 2 μg 12 hrs, larvae L3     Rotenone 8 μg 12 hrs, larvae L3
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (Graveley et al., 2011) mE1_20_mRNA_expression_cluster_03
External Data & Images
Linkouts	BDGP expression data • LD25711 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0259169
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele lethal | recessive RhoGAP18BPG43 partially lethal - majority die | pupal stage, with Scer\GAL4pnr-MD237 RhoGAP18BGD12266 viable RhoGAP18B1 RhoGAP18B2 RhoGAP18B4 RhoGAP18B5 RhoGAP18B6 viable, with Scer\GAL4pnr-MD237 RhoGAP18BGD12250 RhoGAP18BGD12256 RhoGAP18BGD15353 Other Phenotypes Allele chemical resistant RhoGAP18B1 RhoGAP18B2 RhoGAP18B4 RhoGAP18B5 RhoGAP18B6 RhoGAP18BEP1439 RhoGAP18BEP1621 RhoGAP18BΔRC chemical resistant, with Scer\GAL4RhoGAP18B-NP1514 RhoGAP18BdsRNA.RA smell perception defective RhoGAP18B1 visible, with Scer\GAL4pnr-MD237 RhoGAP18BGD12266 Phenotype manifest in Allele mesothoracic tergum, with Scer\GAL4pnr-MD237 RhoGAP18BGD12266 trichogen cell, with Scer\GAL4pnr-MD237 RhoGAP18BGD12266
Classical Alleles ( 57 )
For All Classical Alleles Show
Allele of RhoGAP18B Class Mutagen Stocks Known lesion RhoGAP18BNP4129 2 -- RhoGAP18B5-HA-2717 1 -- RhoGAP18B5-HA-2901 1 -- RhoGAP18B5-HA-5069 1 -- RhoGAP18B5-SZ-3083 1 -- RhoGAP18B5-SZ-3417 1 -- RhoGAP18B5-SZ-4080 1 -- RhoGAP18B5-SZ-4094 1 -- RhoGAP18Bd01002 P-element activity 1 -- RhoGAP18Bd05271 P-element activity 1 -- RhoGAP18Bd08872 P-element activity 1 -- RhoGAP18Bd11122a 1 -- RhoGAP18Be01679 1 -- RhoGAP18Be02324 piggyBac transposase 1 -- RhoGAP18Be02346 piggyBac transposase 1 -- RhoGAP18BEP1326 P-element activity 1 -- RhoGAP18Bf01190 piggyBac transposase 1 -- RhoGAP18Bf03742 piggyBac transposase 1 -- RhoGAP18Bf06094 piggyBac transposase 1 -- RhoGAP18BKG00160 P-element activity 1 -- RhoGAP18BMI01863 1 -- RhoGAP18BNP0770 1 -- RhoGAP18BNP1089 1 -- RhoGAP18BNP1097 1 -- RhoGAP18BNP1514 P-element activity 1 Yes RhoGAP18BNP2188 1 -- RhoGAP18BNP3169 1 -- RhoGAP18BNP3178 1 -- RhoGAP18BNP4163 1 -- RhoGAP18BNP5055 1 -- RhoGAP18BNP5121 1 -- RhoGAP18BNP6001 1 -- RhoGAP18BNP6092 1 -- RhoGAP18BNP7136 1 -- RhoGAP18BNP7160 1 -- RhoGAP18BNP7275 1 -- RhoGAP18B1 P-element activity 0 Yes RhoGAP18B2 P-element activity 0 Yes RhoGAP18B4 P-element activity 0 -- RhoGAP18B5-HA-2090 0 -- RhoGAP18B5-HA-2119 0 -- RhoGAP18B5-HA-2284 0 -- RhoGAP18B5 P-element activity 0 -- RhoGAP18B6 P-element activity 0 -- RhoGAP18Bd02256 P-element activity 0 -- RhoGAP18Bd07621 P-element activity 0 -- RhoGAP18Bd09463 P-element activity 0 -- RhoGAP18Bd09663 P-element activity 0 -- RhoGAP18BdsRNA.RA 0 Yes RhoGAP18BEP1439 P-element activity 0 -- RhoGAP18BEP1621 P-element activity 0 -- RhoGAP18BGG01006 0 -- RhoGAP18BGG01250 0 -- RhoGAP18BGG01618 0 -- RhoGAP18BGS9097 0 -- RhoGAP18BPG43 Delta2-3 0 -- RhoGAP18BΔRC Delta2-3 0 Yes
Alleles Carried on Transgenic Constructs ( 12 )
For All Alleles Carried on Transgenic Constructs Show
Allele of RhoGAP18B Class Mutagen Stocks Known lesion RhoGAP18BdsRNA.Scer\UAS in vitro construct - regulatory fusion in vitro construct - RNAi 2 Yes RhoGAP18BGD12250 in vitro construct - RNAi in vitro construct - regulatory fusion 2 Yes RhoGAP18BGD12256 in vitro construct - RNAi in vitro construct - regulatory fusion 2 Yes RhoGAP18BGD12266 in vitro construct - RNAi in vitro construct - regulatory fusion 2 Yes RhoGAP18BGD15353 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes RhoGAP18BJF01658 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes RhoGAP18BKK110544 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes RhoGAP18BHMS02391 in vitro construct - RNAi in vitro construct - regulatory fusion 0 Yes RhoGAP18BNIG.7502R in vitro construct - RNAi in vitro construct - regulatory fusion 0 Yes RhoGAP18BNIG.7531R in vitro construct - RNAi in vitro construct - regulatory fusion 0 Yes RhoGAP18BRA.Scer\UAS in vitro construct - regulatory fusion 0 Yes RhoGAP18BRC.Scer\UAS in vitro construct - regulatory fusion 0 Yes
Aneuploid Aberrations
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD12250} NA P{GD12266} NA P{GD15353} NA P{KK110544} NA P{NIG.7502R} NA P{NIG.7531R} NA P{TRiP.HMS02391} NA P{TRiP.JF01658} NA P{UAS-RhoGAP18B.RA} NA P{UAS-RhoGAP18B.RC} NA P{UAS-RhoGAP18B-dsRNA} NA
Insertions
	Type of insertions Name Expression data insertion of mobile activating element P{EP}RhoGAP18BEP1326 NA P{EP}RhoGAP18BEP1439 NA P{EP}RhoGAP18BEP1621 NA P{GSV6}RhoGAP18BGS9097 NA P{Mae-UAS.6.11}RhoGAP18BGG01006 NA P{Mae-UAS.6.11}RhoGAP18BGG01250 NA P{Mae-UAS.6.11}RhoGAP18BGG01618 NA P{XP}RhoGAP18Bd01002 NA P{XP}RhoGAP18Bd02256 NA P{XP}RhoGAP18Bd05271 NA P{XP}RhoGAP18Bd07621 NA P{XP}RhoGAP18Bd08872 NA P{XP}RhoGAP18Bd09463 NA P{XP}RhoGAP18Bd09663 NA P{XP}RhoGAP18Bd11122a NA miscellaneous insertions Mi{MIC}RhoGAP18BMI01863 NA P{}RhoGAP18B4 NA P{}RhoGAP18B5 NA P{}RhoGAP18B6 NA P{attP.w+.attP}FS4 NA P{RS5}RhoGAP18B5-HA-2090 NA P{RS5}RhoGAP18B5-HA-2119 NA P{RS5}RhoGAP18B5-HA-2284 NA P{RS5}RhoGAP18B5-HA-2717 NA P{RS5}RhoGAP18B5-HA-2901 NA P{RS5}RhoGAP18B5-HA-5069 NA P{RS5}RhoGAP18B5-SZ-3083 NA P{RS5}RhoGAP18B5-SZ-3417 NA P{RS5}RhoGAP18B5-SZ-4080 NA P{RS5}RhoGAP18B5-SZ-4094 NA P{SUPor-P}RhoGAP18BKG00160 NA PBac{RB}RhoGAP18Be01679 NA PBac{RB}RhoGAP18Be02324 NA PBac{RB}RhoGAP18Be02346 NA PBac{WH}RhoGAP18Bf01190 NA PBac{WH}RhoGAP18Bf03742 NA PBac{WH}RhoGAP18Bf06094 NA insertion of enhancer trap binary system P{GawB}RhoGAP18B1 No P{GawB}RhoGAP18B2 No P{GawB}RhoGAP18BNP0770 No P{GawB}RhoGAP18BNP1089 No P{GawB}RhoGAP18BNP1097 No P{GawB}RhoGAP18BNP1514 No P{GawB}RhoGAP18BNP2188 No P{GawB}RhoGAP18BNP3169 No P{GawB}RhoGAP18BNP3178 No P{GawB}RhoGAP18BNP4129 No P{GawB}RhoGAP18BNP4163 No P{GawB}RhoGAP18BNP5055 No P{GawB}RhoGAP18BNP5121 No P{GawB}RhoGAP18BNP6001 No P{GawB}RhoGAP18BNP6092 No P{GawB}RhoGAP18BNP7136 No P{GawB}RhoGAP18BNP7160 No P{GawB}RhoGAP18BNP7275 No P{GawB}RhoGAP18BPG43 No
Gene Ontology: Function, Process & Cellular Component ( 6 unique terms )
Terms Based on Experimental Evidence ( 4 terms )
Molecular Function
CV term Evidence References
GTPase activator activity inferred from direct assay (Rothenfluh et al., 2006)
Biological Process
CV term Evidence References
actin filament organization inferred from mutant phenotype (Kiger et al., 2003) behavioral response to ethanol inferred from mutant phenotype (Rothenfluh et al., 2004) behavioral response to nicotine inferred from mutant phenotype (Rothenfluh et al., 2004)
Cellular Component ( 0 terms)
Terms Based on Predictions or Assertions ( 3 terms )
Molecular Function
CV term Evidence References
GTPase activator activity inferred from sequence or structural similarity with NCBI:NP_064656 (FlyBase Genome Annotators, 2002-2003)
Biological Process
CV term Evidence References
signal transduction inferred from electronic annotation with InterPro:IPR000198, InterPro:IPR008936 (FlyBase Curators et al., 2004-)
Cellular Component
CV term Evidence References
intracellular inferred from electronic annotation with InterPro:IPR000198, InterPro:IPR008936 (FlyBase Curators et al., 2004-)
Sequence Ontology: Class of Gene
	gene   nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
protein-protein
Interacting group Assay References
RhoGAP18B - Ate1 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) RhoGAP18B - CG1105 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) RhoGAP18B - CG3544 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) RhoGAP18B - CG4338 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) RhoGAP18B - Csp anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) RhoGAP18B - Gαo anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) RhoGAP18B - Pli anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) RhoGAP18B - RagC-D anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) RhoGAP18B - gus anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) RhoGAP18B - lok anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) RhoGAP18B - raps experimental knowledge based (Guruharsha et al., 2011)
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions RhoGAP18B allele Gene References
External Data
Linkouts	DroID - A comprehensive database of gene and protein interactions. • FBgn0261461 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 32898
Orthologs
OrthoDB Orthologs (8) - based on analysis using Dmel annotation version 5.41
OrthoDB Ortholog Groups
	OrthoDB orthology group searches (Waterhouse et al., 2011, Nucleic Acids Res. 39(Database issue): D283--D288) Drosophila inclusive ortholog search EOG6N5WGD Dipteran inclusive ortholog search No orthologs identified Insect inclusive ortholog search No orthologs identified Arthropod inclusive ortholog search No orthologs identified Metazoa inclusive ortholog search No orthologs identified
Orthologs in Drosophila Species (EOG6N5WGD)
Organism Common Name Gene AAA Syntenic Ortholog Multiple Dmel Genes in this Orthologous Group Drosophila melanogaster fruit fly  Dmel\RhoGAP18B     Drosophila simulans   Dsim\GD15601     Drosophila sechellia   Dsec\GM22768     Drosophila erecta   Dere\GG18079     Drosophila yakuba   Dyak\GE15474     Drosophila pseudoobscura pseudoobscura   Dpse\GA20396 Y   Drosophila persimilis   Dper\GL14654 Y   Drosophila willistoni   Dwil\GK25097
Orthologs in non-Drosophila Dipterans (None identified)
No non-Drosophilid orthologies identified
Orthologs in non-Dipteran Insects (None identified)
No non-Dipteran orthologies identified
Orthologs in non-Insect Arthropods (None identified)
No non-Insect Arthropod orthologies identified
Orthologs in non-Arthropod Metazoa (None identified)
No non-Arthropod Metazoa orthologies identified
Human Orthologs (0)
Gene OMIM HGNC
AAA Orthologs (5) based on analysis using Dmel annotation version 4.3
Organism Gene Drosophila pseudoobscura pseudoobscura Dpse\GA20396 Drosophila pseudoobscura pseudoobscura Dpse\GA22300 Drosophila persimilis Dper\GL14654 Drosophila persimilis Dper\GL14655 Drosophila grimshawi Dgri\GH24224
Stocks & Reagents
Stocks Listed in FlyBase ( 48 )
Harvard	- P{XP}RhoGAP18Bd01002 - P{XP}RhoGAP18Bd05271 - P{XP}RhoGAP18Bd08872 - PBac{RB}RhoGAP18Be01679 - PBac{RB}RhoGAP18Be02324 - PBac{RB}RhoGAP18Be02346 - PBac{WH}RhoGAP18Bf01190 - PBac{WH}RhoGAP18Bf03742 - PBac{WH}RhoGAP18Bf06094
VDRC	v104589 P{KK110544}VIE-260B v28047 w1118; P{GD12256}v28047 v28039 w1118; P{GD12250}v28039/TM3
	More stocks available...
Genomic Clones ( 1 )
	BACR49A05 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 137 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	LD25711 LP06920
Other clones
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	HL04030 HL07341 LD14570 LD18742 RE02940 RE42510 RE56328 RH07461 RH14057 RH72954 SD02606 SD02607 SD04127 SD07452 SD08603 SD18884 SD23384
Other clones	14324 15070 37120 55431 55998 106066 107586 152917 175466 191674 214315.62 214379.59 214505.58 281211 527204 CK01.41C.F11 CK01.97D.B4 EK050616 EK075738 EK089406 EK097306 EK100462 EK101904 EK112748 EK116659 EK117847 EK120108 EK162951 EK166337 EK182252 EK184046 EK193908 EK194208 EK216012 EK216322 EK217438 EK229560 EK231354 EK233325 EK236220 EK245164 EK248129 EK256257 EK257401 EK264961 EK266071 EK279264 EK281621 EK290810 EK294249 EK306420 EN04723 EN06559 EN07449 EP04927 EP06728 EP06756 EP07928 EP07956 EP08208 EP12048 FGM213A08 RP003021566 RP003044103 RP003045273 RP003056774 RP003072191 RP003083248 RP003089788 RP003114960 RP003117334 RP003119653 RP003121454 RP003122743 RP003126193 RP003134583 RP003146686 RP003162017 RP003163682 RP003164705 RP003178907 RP003192137 RP003225695 RP003234420 RP003260939 RP003263809 RP003277159 RP003297397 RP003317128 RP003321418 RP003329929 RP003355537 RP003382276 RP003392614 RP003427487 RP003440333 RP003443110 RP003480937 RP003501010 RP003503578 RP003504736 RP003518591 RP003519538 RP003526764 RP003539968 RP003544134 RP003544416 RP003561721 RP003572909 RP003589942 RP003607649 RP003613648 RP003624979 RP003634105 RP003661265 RP003668578 RP003671801 RP003682496
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0261461 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 32898
Antibody Information
Other Information
Discoverer
Etymology
	Named 'white rabbit' for its diverse role in regulating responses to abused drugs as described in the song 'White Rabbit' by Jefferson Airplane. (Rothenfluh et al., 2006)
Identification
Relationship to Other Genes
Source for database identity of	Source for identity of: whir 5-131 (Rothenfluh, 2004.2.23)
Source for database merge of	Source for merge of: CG7481 CG7531 (FlyBase, 1996-) Source for merge of: RhoGAP18B CG7502 (FlyBase Genome Annotators, 2008) Source for merge of: RhoGAP18B CG17015 (FlyBase Genome Annotators, 2002-2003) Source for merge of: RhoGAP18B whir (Rothenfluh et al., 2006)
Additional comments	Annotations CG7481 and CG7502 merged as CG42274 in release 5.8 of the genome annotation. (FlyBase Genome Annotators, 2008) Annotations CG7481, CG17015 and CG7531 merged as CG7481 in release 3 of the genome annotation. (FlyBase Genome Annotators, 2002-2003) Source for merge of CG7481 CG7531 was a shared cDNA (date:010720). (FlyBase, 1996-)
Other Comments
	RhoGAP18B is transcribed from at least two promoters separated by approximately 11kb. (Rothenfluh et al., 2006) RhoGAP18B mutants exhibit strong resistance to the sedating effects of ethanol. (Rothenfluh et al., 2006) Mutants show resistance to the behavioral effects of nicotine and altered responses to ethanol. (Rothenfluh et al., 2004) RNAi screen using dsRNA made from templates generated with primers directed against this gene causes a phenotype when assayed in Kc167 and S2R+ cells: increased or polarized (uneven) accumulation of F-actin. (Kiger et al., 2003) dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R+ cell morphology. (Kiger et al., 2003) Mutants are resistant to the behavioral effects of both nicotine and ethanol. Mutants show a strongly accentuated and prolonged startle response, suggesting that they are more sensitive to the sensory input of the alcohol smell, or more responsive to it. (Rothenfluh and Heberlein, 2003)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_133123 NM_133124 NM_001144748 NM_001144749 RefSeq (Proteins) • NP_573351 NP_573352 NP_001138220 NP_001138221 DDBJ / EMBL / GenBank • AA941531 AAF48919 AAF48921 AAL28880 ABF50837 ABF50838 ABF50839 ACL82950 ACL82951 AQ025465 AQ025545 AQ073192 AW942810 AY061332 BH610005 BI356380 CZ471960 CZ472704 CZ474428 CZ475841 CZ476451 CZ476452 CZ476755 CZ476869 CZ480148 CZ480149 CZ480168 CZ483668 CZ486329 CZ486330 CZ488739 DQ486141 DQ486142 DQ486143 Entrez Gene - A searchable database of RefSeq genes. • 32898 UniProtKB/TrEMBL • Q00IM9 Q00IN0 Q9VWL7 Q9VWL9
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Rho GTPase-activating protein domain (IPR000198) Rho GTPase activation protein (IPR008936) BDGP expression data - Patterns of gene expression in Drosophila embryogenesis • LD25711
Linkouts
	DroID - A comprehensive database of gene and protein interactions. • FBgn0261461 DRSC - Results from RNAi screens. • FBgn0261461 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0259169 FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0261461 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 32898 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 32898 modMine - Data generated by the modENCODE project. • FBgn0261461
Synonyms & Secondary IDs ( 10 )
Reported As
Symbol Synonym	5-131   CG7481 (Greenberg and Hatini, 2011, Billuart et al., 2001, Laviolette et al., 2005, Bernards, 2003) CG7502 (Laviolette et al., 2005, Keleman et al., 2009.8.5, Japanese National Institute of Genetics, 2012.5.21) CG7531   CG17015   CG42274 (FlyBase Genome Annotators, 2008, Ni et al., 2008, Ni et al., 2010.12.1) RhoGAP18B (Manh et al., 2005, Devineni et al., 2011, Greenberg and Hatini, 2011, Rothenfluh et al., 2006, Laviolette et al., 2005, Sordella and Van, 2006, Bakal et al., 2007, Kwon et al., 2008, Zeitlinger et al., 2007, Magalhaes et al., 2007, Sun et al., 2012, Japanese National Institute of Genetics, 2012.5.21) whir (Rothenfluh et al., 2006, Joseph et al., 2009, Devineni and Heberlein, 2009, Peru Y Colón de Portugal et al., 2012)
Name Synonym	CG7502   CG42274 (FlyBase Genome Annotators, 2008) RhoGAP18B   Rho GTPase activating protein at 18B   white rabbit (Rothenfluh et al., 2004, Joseph et al., 2009, Rothenfluh et al., 2006, Devineni and Heberlein, 2009)
Secondary FlyBase IDs
	FBgn0030986 FBgn0030987 FBgn0030988 FBgn0040888 FBgn0065041 FBgn0259169
References ( 48 )
Generate a list of	All references relating to this gene ( 48 )
List References by type	Research paper  ( 17 ) Supplementary material  ( 7 ) Review  ( 2 ) Personal communication to FlyBase  ( 10 ) Abstract  ( 2 ) FlyBase analysis  ( 6 ) Stock list  ( 1 ) Website  ( 1 ) Curated genome annotation  ( 2 )
Recent research papers ( 4 )
	Peru Y Colón de Portugal et al., 2012, J. Neurosci. 32(49): 17706--17713 Adult Neuronal Arf6 Controls Ethanol-Induced Behavior with Arfaptin Downstream of Rac1 and RhoGAP18B. [FBrf0220158] Sun et al., 2012, G3 (Bethesda) 2(5): 551--553 Simplified insertion of transgenes onto balancer chromosomes via Recombinase-Mediated Cassette Exchange. [FBrf0218264] Devineni et al., 2011, Fly 5(3): 191--199 The genetic relationships between ethanol preference, acute ethanol sensitivity, and ethanol tolerance in Drosophila melanogaster. [FBrf0214716] Greenberg and Hatini, 2011, Mech. Dev. 128(1-2): 5--17 Systematic expression and loss-of-function analysis defines spatially restricted requirements for Drosophila RhoGEFs and RhoGAPs in leg morphogenesis. [FBrf0212976] Show all research papers ...
Recent reviews (0)
	All reviews listed in FlyBase were published before 2011 Show reviews ...