whir, white rabbit
Please see the JBrowse view of Dmel\RhoGAP18B for information on other features
To submit a correction to a gene model please use the Contact FlyBase form
AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.
Gene model reviewed during 5.55
Gene model reviewed during 5.42
Low-frequency RNA-Seq exon junction(s) not annotated.
Annotated transcripts do not represent all possible combinations of alternative exons and/or alternative promoters.
Transposon in 3' UTR.
Gene model reviewed during 5.49
Gene model reviewed during 5.56
The group(s) of polypeptides indicated below share identical sequence to each other.
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\RhoGAP18B using the Feature Mapper tool.
Comment: maternally deposited
Comment: reported as head epidermis primordium
Comment: reported as head epidermis primordium
Comment: reported as head epidermis primordium
Comment: isoforms RA, RC and RD
Expression in stage P3 pupal leg discs is ubiquitous.
RhoGAP18B isoform RD is detected in both adult head and body whereas isoform RA is just detected in the body and isoform RC predominantly in the adult head.
GBrowse - Visual display of RNA-Seq signals
View Dmel\RhoGAP18B in GBrowse 21-62
1-60.4
Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
Source for identity of: whir 5-131
Source for merge of: RhoGAP18B CG7502
Source for merge of: RhoGAP18B whir
Source for merge of: CG7481 CG7531
Source for merge of: RhoGAP18B CG17015
Annotations CG7481 and CG7502 merged as CG42274 in release 5.8 of the genome annotation.
Annotations CG7481, CG17015 and CG7531 merged as CG7481 in release 3 of the genome annotation.
Source for merge of CG7481 CG7531 was a shared cDNA ( date:010720 ).
Different isoforms of RhoGAP18B act via inhibiting distinct Rho-family GTPases to regulate actin dynamics.
RhoGAP18B is transcribed from at least two promoters separated by approximately 11kb.
RhoGAP18B mutants exhibit strong resistance to the sedating effects of ethanol.
Mutants show resistance to the behavioral effects of nicotine and altered responses to ethanol.
dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R+ cell morphology.
RNAi screen using dsRNA made from templates generated with primers directed against this gene causes a phenotype when assayed in Kc167 and S2R+ cells: increased or polarized (uneven) accumulation of F-actin.
Mutants are resistant to the behavioral effects of both nicotine and ethanol. Mutants show a strongly accentuated and prolonged startle response, suggesting that they are more sensitive to the sensory input of the alcohol smell, or more responsive to it.
Named 'white rabbit' for its diverse role in regulating responses to abused drugs as described in the song 'White Rabbit' by Jefferson Airplane.