DNT1, Spz2, Spz-2, spatzle 2
Multiphase exon postulated: exon reading frame differs in alternative transcripts; overlap >20aa.
Gene model reviewed during 5.46
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\NT1 using the Feature Mapper tool.
GBrowse - Visual display of RNA-Seq signalsView Dmel\NT1 in GBrowse 2
Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
NT1 and spz are expressed in the embryonic lateral muscles in a complementary pattern, suggesting that they may aid targeting by different axonal projections and promote the survival of distinct subsets of neurons.
Identification: BLAST and other bioinformatic tools have identified a neurotrophin sequence homologue exhibiting sequence and structural conservation of functionally-important residues of the neurotrophin cystine-knot family.