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Gene Dmel\nbs

General Information
Symbol	Dmel\nbs	Species	D. melanogaster
Name	nbs	Annotation symbol	CG6754
Feature type	protein_coding_gene	FlyBase ID	FBgn0261530
Gene Model Status	Current	Stock availability	7 publicly available
Also Known As	l(3)67BDp, Nbs1
Genomic Location
Chromosome (arm)	3L	Recombination map	3-[28]
Cytogenetic map	67B1-67C5	Sequence location	3L:9,713,514..9,716,294 [-]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents Beta	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene nbs is referred to in FlyBase by the symbol Dmel\nbs (CG6754, FBgn0261530). It is a protein_coding_gene from Drosophila melanogaster. Its molecular function is unknown. There is experimental evidence that it is involved in the biological process: double-strand break repair via synthesis-dependent strand annealing; response to DNA damage stimulus; telomere maintenance; mitotic G2 DNA damage checkpoint; chromosome organization; signal transduction in response to DNA damage; telomere capping; intrinsic apoptotic signaling pathway in response to DNA damage. 16 alleles are reported. The phenotypes of these alleles are annotated with: eye; chromosome, telomeric region; macrochaeta; mesothoracic tergum; condensed chromosome; imaginal disc; ommatidium; nucleus. It has 3 annotated transcripts and 3 annotated polypeptides. Protein features are: BRCT domain; Forkhead-associated (FHA) domain; Nibrin; SMAD/FHA domain. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of low expression. Peak expression observed within 00-06 hour embryonic stages, in adult female stages. Summary of FlyAtlas Anatomical Expression Data: Expression at moderate levels in the following post-embryonic organs or tissues: adult central nervous system, adult ovary, adult testis. Comments on Affy2 ProbeSet: ProbeSet 1632161_at completely aligns to an exonic region of the only FlyBase-annotated transcript isoform of nbs. Gene sequence location is 3L:9713514..9716294.
User Contributed Data
	Beta version, feedback welcome
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 67B1-67C5   Left limit from non-inclusion within Df(3L)29A6 (citation unavailable) Right limit from inclusion within Df(3L)AC1 (citation unavailable); Limits computationally determined from genome sequence between P{PZ}fry02240 and P{lacW}l(3)L0539L0539&P{PZ}Dhh1rL562
Experimentally Determined Cytological Location
Cytogenetic map Notes References 67C10-67D1     (Flores, 1999.3.11)
Experimentally Determined Recombination Data
Location	3-[28]
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\nbs for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
	Gene model reviewed during 5.45 Mutation/variant in sequenced strain; G to A mutation in 2nd intron splice donor relative to other Dmel strains. Alternative downstream splice donor may be used. DGC clone LD44438 appears problematic: incomplete CDS; does not match other known nibrin proteins.::DATE:2002-06-13 14:54:45::TS:1023994485000
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) nbs-RD FBtr0306039  NM_001259773   2593   816 nbs-RE FBtr0306040  NM_143716   2599   818 nbs-RF FBtr0306041  NM_001259774   2597   331
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein nbs-PD   FBpp0297181   91.2   816   7.96     NP_001246702   AFH04373 nbs-PE   FBpp0297182   91.5   818   8.12     NP_651973   AAF50215 nbs-PF   FBpp0297183   37.6   331   9.41     NP_001246703   AFH04374
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • SMAD/FHA domain (IPR008984) BRCT domain (IPR001357) Forkhead-associated (FHA) domain (IPR000253) Nibrin (IPR016592)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA803525   AA817325   AA942604   AA948961   AA949732   AE014296 AAF50215   AE014296 AFH04373   AE014296 AFH04374   AI387777   AI387909   AI512537   AI532958   AI534586   AW943722   AY061478 AAL29026   BF494626   BF496007   BF504426   BG634731   BP555854   BQ103319   CK132136   CO182426   CO186120   CO288311   CO340213   CO345122   EC068414   EC230599   EC260303   EC260755   EV597803   GH753881   GH758212   GH758536   GH758759   GH777639   GH783274   GH789109   GH790917   GH793743   GH797580   GH798591   GH799310   GH801183   GH807789   GH811442   GH816208   GH819245   GH821785   GH824878   GH826653   GH828321   GH828800   GH834740   GH836970   GH839982   GH840776   GH844276   GH847229   GH850275   GH858861   GH869584   GH872409   GH873143   GH876232   GH882827   GH883450   GH883929   GH884749   GH886822   GH887993   GH890855   GH892637   GH893014   GH894689   GH897118   GH899380   GH901908   GH903376   GH906384   GH907914   GH915473   GH924569   GH924932   GH927773   GH928980   GH931604
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL	Q9VT40 Q95RC6
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Polypeptide Expression
Additional Descriptive Data
Marker for
Subcellular Localization (GO Cellular Component)
CV term Evidence References
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools
Reference	See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes.
FlyAtlas Anatomy Microarray
FlyAtlas Anatomical Expression Data (FlyAtlas-RNA.adult) (FlyAtlas-RNA.larva)    Styles Linear Logarithmic Heatmap Back-to-back    Scales gene max expression Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Expression at moderate levels in the following post-embryonic organs or tissues: adult central nervous system, adult ovary, adult testis. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (>999.999) Linear, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    83.2 Larval Midgut    22.1 Larval Hindgut    53.1 Larval Malpighian Tubules    51 Larval Fat Body    45.8 Larval Salivary Gland    37.7 Larval Trachea    65.975 Larval Carcass    29.225 Adult Head    58.9 Adult Eye    65.2 Adult Brain    121.3 Adult Thoracic-Abdominal Ganglion    120.6 Adult Crop    66.6 Adult Midgut    34.7 Adult Hindgut    68.4 Adult Malpighian Tubules    38.4 Adult Fat Body    24.7 Adult Salivary Gland    41.2 Adult Heart    31.3 Adult VirginFemale Spermatheca    38.7 Adult InseminatedFemale Spermatheca    36.7 Adult Ovary    269.5 Adult Testis    171.5 Adult Male Accessory Gland    82.7 Adult Carcass    36.5 Expression Level Scale  None   Low   Moderate  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    83.2 Larval Midgut    22.1 Larval Hindgut    53.1 Larval Malpighian Tubules    51 Larval Fat Body    45.8 Larval Salivary Gland    37.7 Larval Trachea    65.975 Larval Carcass    29.225 Adult Head    58.9 Adult Eye    65.2 Adult Brain    121.3 Adult Thoracic-Abdominal Ganglion    120.6 Adult Crop    66.6 Adult Midgut    34.7 Adult Hindgut    68.4 Adult Malpighian Tubules    38.4 Adult Fat Body    24.7 Adult Salivary Gland    41.2 Adult Heart    31.3 Adult VirginFemale Spermatheca    38.7 Adult InseminatedFemale Spermatheca    36.7 Adult Ovary    269.5 Adult Testis    171.5 Adult Male Accessory Gland    82.7 Adult Carcass    36.5 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    83.2 Larval Midgut    22.1 Larval Hindgut    53.1 Larval Malpighian Tubules    51 Larval Fat Body    45.8 Larval Salivary Gland    37.7 Larval Trachea    65.975 Larval Carcass    29.225 Adult Head    58.9 Adult Eye    65.2 Adult Brain    121.3 Adult Thoracic-Abdominal Ganglion    120.6 Adult Crop    66.6 Adult Midgut    34.7 Adult Hindgut    68.4 Adult Malpighian Tubules    38.4 Adult Fat Body    24.7 Adult Salivary Gland    41.2 Adult Heart    31.3 Adult VirginFemale Spermatheca    38.7 Adult InseminatedFemale Spermatheca    36.7 Adult Ovary    269.5 Adult Testis    171.5 Adult Male Accessory Gland    82.7 Adult Carcass    36.5 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    83.2 Larval Midgut    22.1 Larval Hindgut    53.1 Larval Malpighian Tubules    51 Larval Fat Body    45.8 Larval Salivary Gland    37.7 Larval Trachea    65.975 Larval Carcass    29.225 Adult Head    58.9 Adult Eye    65.2 Adult Brain    121.3 Adult Thoracic-Abdominal Ganglion    120.6 Adult Crop    66.6 Adult Midgut    34.7 Adult Hindgut    68.4 Adult Malpighian Tubules    38.4 Adult Fat Body    24.7 Adult Salivary Gland    41.2 Adult Heart    31.3 Adult VirginFemale Spermatheca    38.7 Adult InseminatedFemale Spermatheca    36.7 Adult Ovary    269.5 Adult Testis    171.5 Adult Male Accessory Gland    82.7 Adult Carcass    36.5 Expression Level Scale  Very high  log, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    83.2 Larval Midgut    22.1 Larval Hindgut    53.1 Larval Malpighian Tubules    51 Larval Fat Body    45.8 Larval Salivary Gland    37.7 Larval Trachea    65.975 Larval Carcass    29.225 Adult Head    58.9 Adult Eye    65.2 Adult Brain    121.3 Adult Thoracic-Abdominal Ganglion    120.6 Adult Crop    66.6 Adult Midgut    34.7 Adult Hindgut    68.4 Adult Malpighian Tubules    38.4 Adult Fat Body    24.7 Adult Salivary Gland    41.2 Adult Heart    31.3 Adult VirginFemale Spermatheca    38.7 Adult InseminatedFemale Spermatheca    36.7 Adult Ovary    269.5 Adult Testis    171.5 Adult Male Accessory Gland    82.7 Adult Carcass    36.5 Expression Level Scale  None   Low   Moderate  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    83.2 Larval Midgut    22.1 Larval Hindgut    53.1 Larval Malpighian Tubules    51 Larval Fat Body    45.8 Larval Salivary Gland    37.7 Larval Trachea    65.975 Larval Carcass    29.225 Adult Head    58.9 Adult Eye    65.2 Adult Brain    121.3 Adult Thoracic-Abdominal Ganglion    120.6 Adult Crop    66.6 Adult Midgut    34.7 Adult Hindgut    68.4 Adult Malpighian Tubules    38.4 Adult Fat Body    24.7 Adult Salivary Gland    41.2 Adult Heart    31.3 Adult VirginFemale Spermatheca    38.7 Adult InseminatedFemale Spermatheca    36.7 Adult Ovary    269.5 Adult Testis    171.5 Adult Male Accessory Gland    82.7 Adult Carcass    36.5 Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    83.2 Larval Midgut    22.1 Larval Hindgut    53.1 Larval Malpighian Tubules    51 Larval Fat Body    45.8 Larval Salivary Gland    37.7 Larval Trachea    65.975 Larval Carcass    29.225 Adult Head    58.9 Adult Eye    65.2 Adult Brain    121.3 Adult Thoracic-Abdominal Ganglion    120.6 Adult Crop    66.6 Adult Midgut    34.7 Adult Hindgut    68.4 Adult Malpighian Tubules    38.4 Adult Fat Body    24.7 Adult Salivary Gland    41.2 Adult Heart    31.3 Adult VirginFemale Spermatheca    38.7 Adult InseminatedFemale Spermatheca    36.7 Adult Ovary    269.5 Adult Testis    171.5 Adult Male Accessory Gland    82.7 Adult Carcass    36.5 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    83.2 Larval Midgut    22.1 Larval Hindgut    53.1 Larval Malpighian Tubules    51 Larval Fat Body    45.8 Larval Salivary Gland    37.7 Larval Trachea    65.975 Larval Carcass    29.225 Adult Head    58.9 Adult Eye    65.2 Adult Brain    121.3 Adult Thoracic-Abdominal Ganglion    120.6 Adult Crop    66.6 Adult Midgut    34.7 Adult Hindgut    68.4 Adult Malpighian Tubules    38.4 Adult Fat Body    24.7 Adult Salivary Gland    41.2 Adult Heart    31.3 Adult VirginFemale Spermatheca    38.7 Adult InseminatedFemale Spermatheca    36.7 Adult Ovary    269.5 Adult Testis    171.5 Adult Male Accessory Gland    82.7 Adult Carcass    36.5 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    58.9   NA  Eye    65.2   NA  Brain    121.3   83.2  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    120.6   NA  Crop    66.6   22.1  Midgut    34.7   53.1  Hindgut    68.4   51  Malpighian Tubules    38.4   45.8  Fat Body    24.7   37.7  Salivary Gland    41.2   NA  Heart    31.3   65.975  Trachea    NA   NA  VirginFemale Spermatheca    38.7   NA  InseminatedFemale Spermatheca    36.7   NA  Ovary    269.5   NA  Testis    171.5   NA  Male Accessory Gland    82.7   29.225  Carcass    36.5 FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
modENCODE Anatomy RNA-Seq
modENCODE Tissue Expression Data (modENCODE_mRNA-Seq_tissues)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    16 central nervous system, larvae L3    12 central nervous system, pupae P8    10 head, virgin 1-day female    8 head, virgin 4-day female    7 head, virgin 20-day female    7 head, mated 1-day female    6 head, mated 4-day female    5 head, mated 20-day female    6 head, mated 1-day male    11 head, mated 4-day male    10 head, mated 20-day male    13 salivary gland, larvae L3 wandering    1 salivary gland, white prepupae    2 digestive system, larvae L3 wandering    9 digestive system, 1-day adult    6 digestive system, 4-day adult    8 digestive system, 20-day adult    7 fat body, larvae L3 wandering    2 fat body, white prepupae    5 fat body, pupae P8    6 carcass, larvae L3 wandering    9 carcass, 1-day adult    4 carcass, 4-day adult    6 carcass, 20-day adult    7 ovary, virgin 4-day female    59 ovary, mated 4-day female    55 testis, mated 4-day male    12 accessory gland, mated 4-day male    5 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  Linear, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering    16 central nervous system, larvae L3    12 central nervous system, pupae P8    10 head, virgin 1-day female    8 head, virgin 4-day female    7 head, virgin 20-day female    7 head, mated 1-day female    6 head, mated 4-day female    5 head, mated 20-day female    6 head, mated 1-day male    11 head, mated 4-day male    10 head, mated 20-day male    13 salivary gland, larvae L3 wandering    1 salivary gland, white prepupae    2 digestive system, larvae L3 wandering    9 digestive system, 1-day adult    6 digestive system, 4-day adult    8 digestive system, 20-day adult    7 fat body, larvae L3 wandering    2 fat body, white prepupae    5 fat body, pupae P8    6 carcass, larvae L3 wandering    9 carcass, 1-day adult    4 carcass, 4-day adult    6 carcass, 20-day adult    7 ovary, virgin 4-day female  (59) ovary, mated 4-day female  (55) testis, mated 4-day male    12 accessory gland, mated 4-day male    5 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    16 central nervous system, larvae L3    12 central nervous system, pupae P8    10 head, virgin 1-day female    8 head, virgin 4-day female    7 head, virgin 20-day female    7 head, mated 1-day female    6 head, mated 4-day female    5 head, mated 20-day female    6 head, mated 1-day male    11 head, mated 4-day male    10 head, mated 20-day male    13 salivary gland, larvae L3 wandering    1 salivary gland, white prepupae    2 digestive system, larvae L3 wandering    9 digestive system, 1-day adult    6 digestive system, 4-day adult    8 digestive system, 20-day adult    7 fat body, larvae L3 wandering    2 fat body, white prepupae    5 fat body, pupae P8    6 carcass, larvae L3 wandering    9 carcass, 1-day adult    4 carcass, 4-day adult    6 carcass, 20-day adult    7 ovary, virgin 4-day female    59 ovary, mated 4-day female    55 testis, mated 4-day male    12 accessory gland, mated 4-day male    5 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    16 central nervous system, larvae L3    12 central nervous system, pupae P8    10 head, virgin 1-day female    8 head, virgin 4-day female    7 head, virgin 20-day female    7 head, mated 1-day female    6 head, mated 4-day female    5 head, mated 20-day female    6 head, mated 1-day male    11 head, mated 4-day male    10 head, mated 20-day male    13 salivary gland, larvae L3 wandering    1 salivary gland, white prepupae    2 digestive system, larvae L3 wandering    9 digestive system, 1-day adult    6 digestive system, 4-day adult    8 digestive system, 20-day adult    7 fat body, larvae L3 wandering    2 fat body, white prepupae    5 fat body, pupae P8    6 carcass, larvae L3 wandering    9 carcass, 1-day adult    4 carcass, 4-day adult    6 carcass, 20-day adult    7 ovary, virgin 4-day female    59 ovary, mated 4-day female    55 testis, mated 4-day male    12 accessory gland, mated 4-day male    5 Expression Level Scale  Extremely high  log, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    16 central nervous system, larvae L3    12 central nervous system, pupae P8    10 head, virgin 1-day female    8 head, virgin 4-day female    7 head, virgin 20-day female    7 head, mated 1-day female    6 head, mated 4-day female    5 head, mated 20-day female    6 head, mated 1-day male    11 head, mated 4-day male    10 head, mated 20-day male    13 salivary gland, larvae L3 wandering    1 salivary gland, white prepupae    2 digestive system, larvae L3 wandering    9 digestive system, 1-day adult    6 digestive system, 4-day adult    8 digestive system, 20-day adult    7 fat body, larvae L3 wandering    2 fat body, white prepupae    5 fat body, pupae P8    6 carcass, larvae L3 wandering    9 carcass, 1-day adult    4 carcass, 4-day adult    6 carcass, 20-day adult    7 ovary, virgin 4-day female    59 ovary, mated 4-day female    55 testis, mated 4-day male    12 accessory gland, mated 4-day male    5 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  log, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering    16 central nervous system, larvae L3    12 central nervous system, pupae P8    10 head, virgin 1-day female    8 head, virgin 4-day female    7 head, virgin 20-day female    7 head, mated 1-day female    6 head, mated 4-day female    5 head, mated 20-day female    6 head, mated 1-day male    11 head, mated 4-day male    10 head, mated 20-day male    13 salivary gland, larvae L3 wandering    1 salivary gland, white prepupae    2 digestive system, larvae L3 wandering    9 digestive system, 1-day adult    6 digestive system, 4-day adult    8 digestive system, 20-day adult    7 fat body, larvae L3 wandering    2 fat body, white prepupae    5 fat body, pupae P8    6 carcass, larvae L3 wandering    9 carcass, 1-day adult    4 carcass, 4-day adult    6 carcass, 20-day adult    7 ovary, virgin 4-day female  (59) ovary, mated 4-day female  (55) testis, mated 4-day male    12 accessory gland, mated 4-day male    5 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    16 central nervous system, larvae L3    12 central nervous system, pupae P8    10 head, virgin 1-day female    8 head, virgin 4-day female    7 head, virgin 20-day female    7 head, mated 1-day female    6 head, mated 4-day female    5 head, mated 20-day female    6 head, mated 1-day male    11 head, mated 4-day male    10 head, mated 20-day male    13 salivary gland, larvae L3 wandering    1 salivary gland, white prepupae    2 digestive system, larvae L3 wandering    9 digestive system, 1-day adult    6 digestive system, 4-day adult    8 digestive system, 20-day adult    7 fat body, larvae L3 wandering    2 fat body, white prepupae    5 fat body, pupae P8    6 carcass, larvae L3 wandering    9 carcass, 1-day adult    4 carcass, 4-day adult    6 carcass, 20-day adult    7 ovary, virgin 4-day female    59 ovary, mated 4-day female    55 testis, mated 4-day male    12 accessory gland, mated 4-day male    5 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    16 central nervous system, larvae L3    12 central nervous system, pupae P8    10 head, virgin 1-day female    8 head, virgin 4-day female    7 head, virgin 20-day female    7 head, mated 1-day female    6 head, mated 4-day female    5 head, mated 20-day female    6 head, mated 1-day male    11 head, mated 4-day male    10 head, mated 20-day male    13 salivary gland, larvae L3 wandering    1 salivary gland, white prepupae    2 digestive system, larvae L3 wandering    9 digestive system, 1-day adult    6 digestive system, 4-day adult    8 digestive system, 20-day adult    7 fat body, larvae L3 wandering    2 fat body, white prepupae    5 fat body, pupae P8    6 carcass, larvae L3 wandering    9 carcass, 1-day adult    4 carcass, 4-day adult    6 carcass, 20-day adult    7 ovary, virgin 4-day female    59 ovary, mated 4-day female    55 testis, mated 4-day male    12 accessory gland, mated 4-day male    5 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Tissue   Expression Level imaginal disc, larvae L3 wandering     central nervous system, larvae L3     central nervous system, pupae P8     head, virgin 1-day female     head, virgin 4-day female     head, virgin 20-day female     head, mated 1-day female     head, mated 4-day female     head, mated 20-day female     head, mated 1-day male     head, mated 4-day male     head, mated 20-day male     salivary gland, larvae L3 wandering     salivary gland, white prepupae     digestive system, larvae L3 wandering     digestive system, 1-day adult     digestive system, 4-day adult     digestive system, 20-day adult     fat body, larvae L3 wandering     fat body, white prepupae     fat body, pupae P8     carcass, larvae L3 wandering     carcass, 1-day adult     carcass, 4-day adult     carcass, 20-day adult     ovary, virgin 4-day female     ovary, mated 4-day female     testis, mated 4-day male     accessory gland, mated 4-day male
modENCODE Development RNA-Seq
modENCODE Temporal Expression Data (modENCODE_mRNA-Seq_U)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of low expression. Peak expression observed within 00-06 hour embryonic stages, in adult female stages. [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    23 embryo 02-04hr    8 embryo 04-06hr    18 embryo 06-08hr    11 embryo 08-10hr    8 embryo 10-12hr    4 embryo 12-14hr    4 embryo 14-16hr    3 embryo 16-18hr    3 embryo 18-20hr    3 embryo 20-22hr    4 embryo 22-24hr    5 larva L1    5 larva L2    4 larva L3 12hr old    3 larva L3 puffstage 1-2    4 larva L3 puffstage 3-6    5 larva L3 puffstage 7-9    8 white prepupae new    7 white prepupae 12hr    10 white prepupae 24hr    12 pupae 2d postWPP    11 pupae 3d postWPP    6 pupae 4d postWPP    5 adult male 01day    7 adult male 05day    9 adult male 30day    8 adult female 01day    13 adult female 05day    24 adult female 30day    24 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    23 embryo 02-04hr    8 embryo 04-06hr    18 embryo 06-08hr    11 embryo 08-10hr    8 embryo 10-12hr    4 embryo 12-14hr    4 embryo 14-16hr    3 embryo 16-18hr    3 embryo 18-20hr    3 embryo 20-22hr    4 embryo 22-24hr    5 larva L1    5 larva L2    4 larva L3 12hr old    3 larva L3 puffstage 1-2    4 larva L3 puffstage 3-6    5 larva L3 puffstage 7-9    8 white prepupae new    7 white prepupae 12hr    10 white prepupae 24hr    12 pupae 2d postWPP    11 pupae 3d postWPP    6 pupae 4d postWPP    5 adult male 01day    7 adult male 05day    9 adult male 30day    8 adult female 01day    13 adult female 05day    24 adult female 30day    24 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    23 embryo 02-04hr    8 embryo 04-06hr    18 embryo 06-08hr    11 embryo 08-10hr    8 embryo 10-12hr    4 embryo 12-14hr    4 embryo 14-16hr    3 embryo 16-18hr    3 embryo 18-20hr    3 embryo 20-22hr    4 embryo 22-24hr    5 larva L1    5 larva L2    4 larva L3 12hr old    3 larva L3 puffstage 1-2    4 larva L3 puffstage 3-6    5 larva L3 puffstage 7-9    8 white prepupae new    7 white prepupae 12hr    10 white prepupae 24hr    12 pupae 2d postWPP    11 pupae 3d postWPP    6 pupae 4d postWPP    5 adult male 01day    7 adult male 05day    9 adult male 30day    8 adult female 01day    13 adult female 05day    24 adult female 30day    24 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    23 embryo 02-04hr    8 embryo 04-06hr    18 embryo 06-08hr    11 embryo 08-10hr    8 embryo 10-12hr    4 embryo 12-14hr    4 embryo 14-16hr    3 embryo 16-18hr    3 embryo 18-20hr    3 embryo 20-22hr    4 embryo 22-24hr    5 larva L1    5 larva L2    4 larva L3 12hr old    3 larva L3 puffstage 1-2    4 larva L3 puffstage 3-6    5 larva L3 puffstage 7-9    8 white prepupae new    7 white prepupae 12hr    10 white prepupae 24hr    12 pupae 2d postWPP    11 pupae 3d postWPP    6 pupae 4d postWPP    5 adult male 01day    7 adult male 05day    9 adult male 30day    8 adult female 01day    13 adult female 05day    24 adult female 30day    24 Expression Level Scale  Extremely high  log, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    23 embryo 02-04hr    8 embryo 04-06hr    18 embryo 06-08hr    11 embryo 08-10hr    8 embryo 10-12hr    4 embryo 12-14hr    4 embryo 14-16hr    3 embryo 16-18hr    3 embryo 18-20hr    3 embryo 20-22hr    4 embryo 22-24hr    5 larva L1    5 larva L2    4 larva L3 12hr old    3 larva L3 puffstage 1-2    4 larva L3 puffstage 3-6    5 larva L3 puffstage 7-9    8 white prepupae new    7 white prepupae 12hr    10 white prepupae 24hr    12 pupae 2d postWPP    11 pupae 3d postWPP    6 pupae 4d postWPP    5 adult male 01day    7 adult male 05day    9 adult male 30day    8 adult female 01day    13 adult female 05day    24 adult female 30day    24 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    23 embryo 02-04hr    8 embryo 04-06hr    18 embryo 06-08hr    11 embryo 08-10hr    8 embryo 10-12hr    4 embryo 12-14hr    4 embryo 14-16hr    3 embryo 16-18hr    3 embryo 18-20hr    3 embryo 20-22hr    4 embryo 22-24hr    5 larva L1    5 larva L2    4 larva L3 12hr old    3 larva L3 puffstage 1-2    4 larva L3 puffstage 3-6    5 larva L3 puffstage 7-9    8 white prepupae new    7 white prepupae 12hr    10 white prepupae 24hr    12 pupae 2d postWPP    11 pupae 3d postWPP    6 pupae 4d postWPP    5 adult male 01day    7 adult male 05day    9 adult male 30day    8 adult female 01day    13 adult female 05day    24 adult female 30day    24 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    23 embryo 02-04hr    8 embryo 04-06hr    18 embryo 06-08hr    11 embryo 08-10hr    8 embryo 10-12hr    4 embryo 12-14hr    4 embryo 14-16hr    3 embryo 16-18hr    3 embryo 18-20hr    3 embryo 20-22hr    4 embryo 22-24hr    5 larva L1    5 larva L2    4 larva L3 12hr old    3 larva L3 puffstage 1-2    4 larva L3 puffstage 3-6    5 larva L3 puffstage 7-9    8 white prepupae new    7 white prepupae 12hr    10 white prepupae 24hr    12 pupae 2d postWPP    11 pupae 3d postWPP    6 pupae 4d postWPP    5 adult male 01day    7 adult male 05day    9 adult male 30day    8 adult female 01day    13 adult female 05day    24 adult female 30day    24 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    23 embryo 02-04hr    8 embryo 04-06hr    18 embryo 06-08hr    11 embryo 08-10hr    8 embryo 10-12hr    4 embryo 12-14hr    4 embryo 14-16hr    3 embryo 16-18hr    3 embryo 18-20hr    3 embryo 20-22hr    4 embryo 22-24hr    5 larva L1    5 larva L2    4 larva L3 12hr old    3 larva L3 puffstage 1-2    4 larva L3 puffstage 3-6    5 larva L3 puffstage 7-9    8 white prepupae new    7 white prepupae 12hr    10 white prepupae 24hr    12 pupae 2d postWPP    11 pupae 3d postWPP    6 pupae 4d postWPP    5 adult male 01day    7 adult male 05day    9 adult male 30day    8 adult female 01day    13 adult female 05day    24 adult female 30day    24 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     modENCODE Temporal Expression Data (Graveley et al., 2011)
modENCODE Cell Lines RNA-Seq
modENCODE Cell Line Expression Data (modENCODE_mRNA-Seq_cell.A) (modENCODE_mRNA-Seq_cell.B)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    24 Schneider line 2 Sg4    13 embryonic 1182-4H    34 embryonic GM2    25 embryonic Kc167    66 embryonic S1    33 embryonic S3    19 leg disc CME L1    25 wing disc CME-W2    41 wing disc ML-DmD8    26 wing disc ML-DmD9    29 wing disc ML-DmD16-c3    29 wing disc ML-DmD21    9 wing disc ML-DmD32    21 haltere disc ML-DmD17-c3    29 eye-antennal disc ML-DmD11    33 antennal disc ML-DmD20-c5    20 mixed discs ML-DmD4-c1    19 CNS ML-DmBG1-c1    38 CNS ML-DmBG2-c2    17 tumorous blood cells mbn2    19 ovary fGS/OSS    34 ovary OSC    30 ovary OSS    10 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  Linear, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+    24 Schneider line 2 Sg4    13 embryonic 1182-4H  (34) embryonic GM2    25 embryonic Kc167  (66) embryonic S1  (33) embryonic S3    19 leg disc CME L1    25 wing disc CME-W2  (41) wing disc ML-DmD8  26 wing disc ML-DmD9  (29) wing disc ML-DmD16-c3  (29) wing disc ML-DmD21    9 wing disc ML-DmD32    21 haltere disc ML-DmD17-c3  (29) eye-antennal disc ML-DmD11  (33) antennal disc ML-DmD20-c5    20 mixed discs ML-DmD4-c1    19 CNS ML-DmBG1-c1  (38) CNS ML-DmBG2-c2    17 tumorous blood cells mbn2    19 ovary fGS/OSS  (34) ovary OSC  (30) ovary OSS    10 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    24 Schneider line 2 Sg4    13 embryonic 1182-4H    34 embryonic GM2    25 embryonic Kc167    66 embryonic S1    33 embryonic S3    19 leg disc CME L1    25 wing disc CME-W2    41 wing disc ML-DmD8    26 wing disc ML-DmD9    29 wing disc ML-DmD16-c3    29 wing disc ML-DmD21    9 wing disc ML-DmD32    21 haltere disc ML-DmD17-c3    29 eye-antennal disc ML-DmD11    33 antennal disc ML-DmD20-c5    20 mixed discs ML-DmD4-c1    19 CNS ML-DmBG1-c1    38 CNS ML-DmBG2-c2    17 tumorous blood cells mbn2    19 ovary fGS/OSS    34 ovary OSC    30 ovary OSS    10 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    24 Schneider line 2 Sg4    13 embryonic 1182-4H    34 embryonic GM2    25 embryonic Kc167    66 embryonic S1    33 embryonic S3    19 leg disc CME L1    25 wing disc CME-W2    41 wing disc ML-DmD8    26 wing disc ML-DmD9    29 wing disc ML-DmD16-c3    29 wing disc ML-DmD21    9 wing disc ML-DmD32    21 haltere disc ML-DmD17-c3    29 eye-antennal disc ML-DmD11    33 antennal disc ML-DmD20-c5    20 mixed discs ML-DmD4-c1    19 CNS ML-DmBG1-c1    38 CNS ML-DmBG2-c2    17 tumorous blood cells mbn2    19 ovary fGS/OSS    34 ovary OSC    30 ovary OSS    10 Expression Level Scale  Extremely high  log, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    24 Schneider line 2 Sg4    13 embryonic 1182-4H    34 embryonic GM2    25 embryonic Kc167    66 embryonic S1    33 embryonic S3    19 leg disc CME L1    25 wing disc CME-W2    41 wing disc ML-DmD8    26 wing disc ML-DmD9    29 wing disc ML-DmD16-c3    29 wing disc ML-DmD21    9 wing disc ML-DmD32    21 haltere disc ML-DmD17-c3    29 eye-antennal disc ML-DmD11    33 antennal disc ML-DmD20-c5    20 mixed discs ML-DmD4-c1    19 CNS ML-DmBG1-c1    38 CNS ML-DmBG2-c2    17 tumorous blood cells mbn2    19 ovary fGS/OSS    34 ovary OSC    30 ovary OSS    10 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  log, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+    24 Schneider line 2 Sg4    13 embryonic 1182-4H  (34) embryonic GM2    25 embryonic Kc167  (66) embryonic S1  (33) embryonic S3    19 leg disc CME L1    25 wing disc CME-W2  (41) wing disc ML-DmD8  26 wing disc ML-DmD9  29 wing disc ML-DmD16-c3  29 wing disc ML-DmD21    9 wing disc ML-DmD32    21 haltere disc ML-DmD17-c3  29 eye-antennal disc ML-DmD11  (33) antennal disc ML-DmD20-c5    20 mixed discs ML-DmD4-c1    19 CNS ML-DmBG1-c1  (38) CNS ML-DmBG2-c2    17 tumorous blood cells mbn2    19 ovary fGS/OSS  (34) ovary OSC  30 ovary OSS    10 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    24 Schneider line 2 Sg4    13 embryonic 1182-4H    34 embryonic GM2    25 embryonic Kc167    66 embryonic S1    33 embryonic S3    19 leg disc CME L1    25 wing disc CME-W2    41 wing disc ML-DmD8    26 wing disc ML-DmD9    29 wing disc ML-DmD16-c3    29 wing disc ML-DmD21    9 wing disc ML-DmD32    21 haltere disc ML-DmD17-c3    29 eye-antennal disc ML-DmD11    33 antennal disc ML-DmD20-c5    20 mixed discs ML-DmD4-c1    19 CNS ML-DmBG1-c1    38 CNS ML-DmBG2-c2    17 tumorous blood cells mbn2    19 ovary fGS/OSS    34 ovary OSC    30 ovary OSS    10 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    24 Schneider line 2 Sg4    13 embryonic 1182-4H    34 embryonic GM2    25 embryonic Kc167    66 embryonic S1    33 embryonic S3    19 leg disc CME L1    25 wing disc CME-W2    41 wing disc ML-DmD8    26 wing disc ML-DmD9    29 wing disc ML-DmD16-c3    29 wing disc ML-DmD21    9 wing disc ML-DmD32    21 haltere disc ML-DmD17-c3    29 eye-antennal disc ML-DmD11    33 antennal disc ML-DmD20-c5    20 mixed discs ML-DmD4-c1    19 CNS ML-DmBG1-c1    38 CNS ML-DmBG2-c2    17 tumorous blood cells mbn2    19 ovary fGS/OSS    34 ovary OSC    30 ovary OSS    10 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Cell Line   Expression Level Schneider line 2 S2R+     Schneider line 2 Sg4     embryonic 1182-4H     embryonic GM2     embryonic Kc167     embryonic S1     embryonic S3     leg disc CME L1     wing disc CME-W2     wing disc ML-DmD8     wing disc ML-DmD9     wing disc ML-DmD16-c3     wing disc ML-DmD21     wing disc ML-DmD32     haltere disc ML-DmD17-c3     eye-antennal disc ML-DmD11     antennal disc ML-DmD20-c5     mixed discs ML-DmD4-c1     CNS ML-DmBG1-c1     CNS ML-DmBG2-c2     tumorous blood cells mbn2     ovary fGS/OSS     ovary OSC     ovary OSS
modENCODE Treatments RNA-Seq
modENCODE Treatment Expression Data (modENCODE_mRNA-Seq_treatments)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    9 cold shock, 4-day adult    6 heat shock, 4-day adult    15 Cadmium 50 mM 6 hrs, larvae L3    4 Cadmium 50 mM 12 hrs, larvae L3    7 Cadmium 50 mM 48 hrs, 4-day adult    15 Cadmium 100 mM 48 hrs, 4-day adult    38 Copper 0.5 mM 12 hrs, larvae L3    2 Copper 15 mM 48 hrs, 4-day adult    25 Zinc 5 mM 12 hrs, larvae L3    3 Zinc 4.5 mM 48 hrs, 4-day adult    14 Ethanol 2.5% 3 hrs, larvae L3    30 Ethanol 5% 3 hrs, larvae L3    6 Ethanol 10% 3 hrs, larvae L3    4 Caffeine 1.5 mg/ml 4 hrs, larvae L3    8 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    34 Caffeine 25 mg/ml 48 hrs, 4-day adult    11 Paraquat 5 mM 48 hrs, 4-day adult    27 Paraquat 10 mM 48 hrs, 4-day adult    25 Rotenone 2 μg 12 hrs, larvae L3    6 Rotenone 8 μg 12 hrs, larvae L3    2 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult    9 cold shock, 4-day adult    6 heat shock, 4-day adult    15 Cadmium 50 mM 6 hrs, larvae L3    4 Cadmium 50 mM 12 hrs, larvae L3    7 Cadmium 50 mM 48 hrs, 4-day adult    15 Cadmium 100 mM 48 hrs, 4-day adult  (38) Copper 0.5 mM 12 hrs, larvae L3    2 Copper 15 mM 48 hrs, 4-day adult    25 Zinc 5 mM 12 hrs, larvae L3    3 Zinc 4.5 mM 48 hrs, 4-day adult    14 Ethanol 2.5% 3 hrs, larvae L3  (30) Ethanol 5% 3 hrs, larvae L3    6 Ethanol 10% 3 hrs, larvae L3    4 Caffeine 1.5 mg/ml 4 hrs, larvae L3    8 Caffeine 2.5 mg/ml 48 hrs, 4-day adult  (34) Caffeine 25 mg/ml 48 hrs, 4-day adult    11 Paraquat 5 mM 48 hrs, 4-day adult  (27) Paraquat 10 mM 48 hrs, 4-day adult    25 Rotenone 2 μg 12 hrs, larvae L3    6 Rotenone 8 μg 12 hrs, larvae L3    2 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    9 cold shock, 4-day adult    6 heat shock, 4-day adult    15 Cadmium 50 mM 6 hrs, larvae L3    4 Cadmium 50 mM 12 hrs, larvae L3    7 Cadmium 50 mM 48 hrs, 4-day adult    15 Cadmium 100 mM 48 hrs, 4-day adult    38 Copper 0.5 mM 12 hrs, larvae L3    2 Copper 15 mM 48 hrs, 4-day adult    25 Zinc 5 mM 12 hrs, larvae L3    3 Zinc 4.5 mM 48 hrs, 4-day adult    14 Ethanol 2.5% 3 hrs, larvae L3    30 Ethanol 5% 3 hrs, larvae L3    6 Ethanol 10% 3 hrs, larvae L3    4 Caffeine 1.5 mg/ml 4 hrs, larvae L3    8 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    34 Caffeine 25 mg/ml 48 hrs, 4-day adult    11 Paraquat 5 mM 48 hrs, 4-day adult    27 Paraquat 10 mM 48 hrs, 4-day adult    25 Rotenone 2 μg 12 hrs, larvae L3    6 Rotenone 8 μg 12 hrs, larvae L3    2 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    9 cold shock, 4-day adult    6 heat shock, 4-day adult    15 Cadmium 50 mM 6 hrs, larvae L3    4 Cadmium 50 mM 12 hrs, larvae L3    7 Cadmium 50 mM 48 hrs, 4-day adult    15 Cadmium 100 mM 48 hrs, 4-day adult    38 Copper 0.5 mM 12 hrs, larvae L3    2 Copper 15 mM 48 hrs, 4-day adult    25 Zinc 5 mM 12 hrs, larvae L3    3 Zinc 4.5 mM 48 hrs, 4-day adult    14 Ethanol 2.5% 3 hrs, larvae L3    30 Ethanol 5% 3 hrs, larvae L3    6 Ethanol 10% 3 hrs, larvae L3    4 Caffeine 1.5 mg/ml 4 hrs, larvae L3    8 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    34 Caffeine 25 mg/ml 48 hrs, 4-day adult    11 Paraquat 5 mM 48 hrs, 4-day adult    27 Paraquat 10 mM 48 hrs, 4-day adult    25 Rotenone 2 μg 12 hrs, larvae L3    6 Rotenone 8 μg 12 hrs, larvae L3    2 Expression Level Scale  Extremely high  log, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    9 cold shock, 4-day adult    6 heat shock, 4-day adult    15 Cadmium 50 mM 6 hrs, larvae L3    4 Cadmium 50 mM 12 hrs, larvae L3    7 Cadmium 50 mM 48 hrs, 4-day adult    15 Cadmium 100 mM 48 hrs, 4-day adult    38 Copper 0.5 mM 12 hrs, larvae L3    2 Copper 15 mM 48 hrs, 4-day adult    25 Zinc 5 mM 12 hrs, larvae L3    3 Zinc 4.5 mM 48 hrs, 4-day adult    14 Ethanol 2.5% 3 hrs, larvae L3    30 Ethanol 5% 3 hrs, larvae L3    6 Ethanol 10% 3 hrs, larvae L3    4 Caffeine 1.5 mg/ml 4 hrs, larvae L3    8 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    34 Caffeine 25 mg/ml 48 hrs, 4-day adult    11 Paraquat 5 mM 48 hrs, 4-day adult    27 Paraquat 10 mM 48 hrs, 4-day adult    25 Rotenone 2 μg 12 hrs, larvae L3    6 Rotenone 8 μg 12 hrs, larvae L3    2 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  log, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult    9 cold shock, 4-day adult    6 heat shock, 4-day adult    15 Cadmium 50 mM 6 hrs, larvae L3    4 Cadmium 50 mM 12 hrs, larvae L3    7 Cadmium 50 mM 48 hrs, 4-day adult    15 Cadmium 100 mM 48 hrs, 4-day adult  (38) Copper 0.5 mM 12 hrs, larvae L3    2 Copper 15 mM 48 hrs, 4-day adult    25 Zinc 5 mM 12 hrs, larvae L3    3 Zinc 4.5 mM 48 hrs, 4-day adult    14 Ethanol 2.5% 3 hrs, larvae L3  30 Ethanol 5% 3 hrs, larvae L3    6 Ethanol 10% 3 hrs, larvae L3    4 Caffeine 1.5 mg/ml 4 hrs, larvae L3    8 Caffeine 2.5 mg/ml 48 hrs, 4-day adult  (34) Caffeine 25 mg/ml 48 hrs, 4-day adult    11 Paraquat 5 mM 48 hrs, 4-day adult  27 Paraquat 10 mM 48 hrs, 4-day adult    25 Rotenone 2 μg 12 hrs, larvae L3    6 Rotenone 8 μg 12 hrs, larvae L3    2 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    9 cold shock, 4-day adult    6 heat shock, 4-day adult    15 Cadmium 50 mM 6 hrs, larvae L3    4 Cadmium 50 mM 12 hrs, larvae L3    7 Cadmium 50 mM 48 hrs, 4-day adult    15 Cadmium 100 mM 48 hrs, 4-day adult    38 Copper 0.5 mM 12 hrs, larvae L3    2 Copper 15 mM 48 hrs, 4-day adult    25 Zinc 5 mM 12 hrs, larvae L3    3 Zinc 4.5 mM 48 hrs, 4-day adult    14 Ethanol 2.5% 3 hrs, larvae L3    30 Ethanol 5% 3 hrs, larvae L3    6 Ethanol 10% 3 hrs, larvae L3    4 Caffeine 1.5 mg/ml 4 hrs, larvae L3    8 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    34 Caffeine 25 mg/ml 48 hrs, 4-day adult    11 Paraquat 5 mM 48 hrs, 4-day adult    27 Paraquat 10 mM 48 hrs, 4-day adult    25 Rotenone 2 μg 12 hrs, larvae L3    6 Rotenone 8 μg 12 hrs, larvae L3    2 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    9 cold shock, 4-day adult    6 heat shock, 4-day adult    15 Cadmium 50 mM 6 hrs, larvae L3    4 Cadmium 50 mM 12 hrs, larvae L3    7 Cadmium 50 mM 48 hrs, 4-day adult    15 Cadmium 100 mM 48 hrs, 4-day adult    38 Copper 0.5 mM 12 hrs, larvae L3    2 Copper 15 mM 48 hrs, 4-day adult    25 Zinc 5 mM 12 hrs, larvae L3    3 Zinc 4.5 mM 48 hrs, 4-day adult    14 Ethanol 2.5% 3 hrs, larvae L3    30 Ethanol 5% 3 hrs, larvae L3    6 Ethanol 10% 3 hrs, larvae L3    4 Caffeine 1.5 mg/ml 4 hrs, larvae L3    8 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    34 Caffeine 25 mg/ml 48 hrs, 4-day adult    11 Paraquat 5 mM 48 hrs, 4-day adult    27 Paraquat 10 mM 48 hrs, 4-day adult    25 Rotenone 2 μg 12 hrs, larvae L3    6 Rotenone 8 μg 12 hrs, larvae L3    2 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Treatment   Expression Level extended cold, 4-day adult     cold shock, 4-day adult     heat shock, 4-day adult     Cadmium 50 mM 6 hrs, larvae L3     Cadmium 50 mM 12 hrs, larvae L3     Cadmium 50 mM 48 hrs, 4-day adult     Cadmium 100 mM 48 hrs, 4-day adult     Copper 0.5 mM 12 hrs, larvae L3     Copper 15 mM 48 hrs, 4-day adult     Zinc 5 mM 12 hrs, larvae L3     Zinc 4.5 mM 48 hrs, 4-day adult     Ethanol 2.5% 3 hrs, larvae L3     Ethanol 5% 3 hrs, larvae L3     Ethanol 10% 3 hrs, larvae L3     Caffeine 1.5 mg/ml 4 hrs, larvae L3     Caffeine 2.5 mg/ml 48 hrs, 4-day adult     Caffeine 25 mg/ml 48 hrs, 4-day adult     Paraquat 5 mM 48 hrs, 4-day adult     Paraquat 10 mM 48 hrs, 4-day adult     Rotenone 2 μg 12 hrs, larvae L3     Rotenone 8 μg 12 hrs, larvae L3
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (Graveley et al., 2011) mE1_20_mRNA_expression_cluster_05
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0086349
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele lethal nbs2 lethal | larval stage | recessive nbs1 lethal | pharate adult stage nbs1 lethal | pharate adult stage (with nbs1) nbs2 lethal | pharate adult stage (with nbs2) nbs1 lethal | pupal stage | recessive nbs1 nbsM7 viable nbs434.T:SV5\V5 nbsEY15506 viable, with Scer\GAL4pnr-MD237 nbsGD12399 viable (with nbs1) nbsEY15506 viable (with nbsEY15506) nbs1 Sterility Allele female sterile nbsΔ180 fertile nbs434.T:SV5\V5 nbsEY15506 male fertile nbsΔ180 Other Phenotypes Allele body color defective, with Scer\GAL4pnr-MD237 nbsGD12399 DNA repair defective (with nbs1) nbsSM9 DNA repair defective (with nbsSM9) nbs1 DNA repair defective | dominant nbs1 increased cell death nbs1 increased cell death (with nbs1) nbs2 increased cell death (with nbs2) nbs1 mitotic cell cycle defective nbsΔ180 mitotic cell cycle defective (with Df(3R)PG4) nbs1 radiation sensitive nbs1 radiation sensitive (with nbs1) nbsEY15506 nbsSM9 radiation sensitive (with nbsEY15506) nbs1 radiation sensitive (with nbsSM9) nbs1 Phenotype manifest in Allele chromosome, telomeric region nbs1 chromosome, telomeric region (with Df(3L)AC1) nbs1 chromosome & neuroblast | third instar larval stage 2 nbs1 condensed chromosome nbs1 condensed chromosome (with Df(3L)AC1) nbs1 eye nbs1 eye (with nbs1) nbs2 eye (with nbs2) nbs1 imaginal disc nbs1 macrochaeta nbs1 macrochaeta (with nbs1) nbs2 macrochaeta (with nbs2) nbs1 mesothoracic tergum, with Scer\GAL4pnr-MD237 nbsGD12399 nucleus nbsΔ180 ommatidium nbs1
Classical Alleles ( 13 )
For All Classical Alleles Show
Allele of nbs Class Mutagen Stocks Known lesion nbs1 amorphic allele - genetic evidence ethyl methanesulfonate 2 Yes nbs2 ethyl methanesulfonate 2 Yes nbsEY15506 hypomorphic allele - genetic evidence P-element activity 1 Yes nbs434.T:SV5\V5 recombination ends-in gene targeting 0 Yes nbsdefl-Δ Delta2-3 0 Yes nbsM1.T:SV5\V5 recombination I-CreI endonuclease 0 Yes nbsM2.T:SV5\V5 recombination I-CreI endonuclease 0 Yes nbsM3.T:SV5\V5 recombination I-CreI endonuclease 0 Yes nbsM4.T:SV5\V5 recombination I-CreI endonuclease 0 Yes nbsM5.T:SV5\V5 recombination I-CreI endonuclease 0 Yes nbsM7 recombination I-CreI endonuclease 0 Yes nbsSM9 P-element activity 0 Yes nbsΔ180 0 Yes
Alleles Carried on Transgenic Constructs ( 3 )
For All Alleles Carried on Transgenic Constructs Show
Allele of nbs Class Mutagen Stocks Known lesion nbsGD12399 in vitro construct - RNAi in vitro construct - regulatory fusion 2 Yes nbsKK101013 in vitro construct - RNAi in vitro construct - regulatory fusion 0 Yes nbsScer\UAS.cOa in vitro construct - regulatory fusion 0 Yes
Aneuploid Aberrations
Disrupted in	Df(3L)BSC46 (Andrade and Cook, 2003.12.11)
Partially disrupted in	Df(3L)deflΔ (Rutkowski and Warren, 2009)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD12399} NA P{KK101013} NA P{UAS-nbs.O} NA
Insertions
	Type of insertions Name Expression data insertion of mobile activating element P{EPgy2}nbsEY15506 NA miscellaneous insertions P{5'EPgy2.SM9}nbsSM9 NA
Gene Ontology: Function, Process & Cellular Component ( 8 unique terms )
Terms Based on Experimental Evidence ( 8 terms )
Molecular Function ( 0 terms)
Biological Process
CV term Evidence References
chromosome organization inferred from mutant phenotype (Ciapponi et al., 2006) double-strand break repair via synthesis-dependent strand annealing inferred from mutant phenotype (Mukherjee et al., 2009) intrinsic apoptotic signaling pathway in response to DNA damage inferred from mutant phenotype (Oikemus et al., 2006) mitotic G2 DNA damage checkpoint inferred from mutant phenotype (Mukherjee et al., 2009) response to DNA damage stimulus inferred from mutant phenotype (Ravi et al., 2009) signal transduction in response to DNA damage inferred from mutant phenotype (Oikemus et al., 2006) telomere capping inferred from direct assay (Gao et al., 2009) inferred from mutant phenotype (Ciapponi et al., 2006) telomere maintenance inferred from mutant phenotype (Bi et al., 2005)
Cellular Component ( 0 terms)
Terms Based on Predictions or Assertions ( 0 terms )
Sequence Ontology: Class of Gene
	gene   nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions nbs allele Gene References unspecified mei-41 (Ciapponi et al., 2006) rad50 (Ciapponi et al., 2006) tefu (Ciapponi et al., 2006)
External Data
Linkouts	DroID - A comprehensive database of gene and protein interactions. • FBgn0261530 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 44259 SignaLink - A protein-protein and protein-miRNA interaction database with multi-layered structure and multiple confidence scores. • Q9VT40
Orthologs
OrthoDB Orthologs (41) - based on analysis using Dmel annotation version 5.41
OrthoDB Ortholog Groups
	OrthoDB orthology group searches (Waterhouse et al., 2011, Nucleic Acids Res. 39(Database issue): D283--D288) Drosophila inclusive ortholog search EOG6JM88J Dipteran inclusive ortholog search EOG6VX2DP Insect inclusive ortholog search EOG6PG4W7 Arthropod inclusive ortholog search EOG663XT7 Metazoa inclusive ortholog search EOG622PC0
Orthologs in Drosophila Species (EOG6JM88J)
Organism Common Name Gene AAA Syntenic Ortholog Multiple Dmel Genes in this Orthologous Group Drosophila melanogaster fruit fly  Dmel\nbs     Drosophila simulans   Dsim\GD12898     Drosophila sechellia   Dsec\GM24846     Drosophila erecta   Dere\GG14012     Drosophila yakuba   Dyak\GE21214     Drosophila ananassae   Dana\GF25130     Drosophila pseudoobscura pseudoobscura   Dpse\GA19836     Drosophila persimilis   Dper\GL16334     Drosophila willistoni   Dwil\GK11834     Drosophila virilis   Dvir\GJ13224     Drosophila mojavensis   Dmoj\GI12286     Drosophila grimshawi   Dgri\GH16022
Orthologs in non-Drosophila Dipterans (EOG6VX2DP)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Aedes aegypti Yellow fever mosquito  Aaeg\AAEL014377   Anopheles gambiae Malaria mosquito  Agam\AGAP003213   Culex quinquefasciatus Southern house mosquito  Cqui\CPIJ016385
Orthologs in non-Dipteran Insects (EOG6PG4W7)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Apis mellifera Western honey bee  Amel\GB48908   Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG013963   Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG025046   Camponotus floridanus Florida carpenter ant  Cflo\CFLO18137   Harpegnathos saltator Jerdons jumping ant  Hsal\HSAL14603   Linepithema humile Argentine ant  Lhum\LH18991   Linepithema humile Argentine ant  Lhum\LH18992   Linepithema humile Argentine ant  Lhum\LH18989   Pogonomyrmex barbatus Red harvester ant  Pbar\PB18639   Solenopsis invicta Red fire ant  Sinv\SINV13487   Solenopsis invicta Red fire ant  Sinv\SINV13486   Solenopsis invicta Red fire ant  Sinv\SINV12413   Acyrthosiphon pisum Pea aphid  Apim\ACYPI004059   Acyrthosiphon pisum Pea aphid  Apim\ACYPI087994   Pediculus humanus Human body louse  Phum\PHUM095740   Tribolium castaneum Red flour beetle  Tcas\nbs
Orthologs in non-Insect Arthropods (EOG663XT7)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Daphnia pulex Water flea  Dpux\Gtf2f2   Ixodes scapularis Deer tick  Isca\ISCW012706
Orthologs in non-Arthropod Metazoa (EOG622PC0)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_021525gn   Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_018395gn   Danio rerio Zebrafish  Drer\nbn   Xenopus tropicalis Western clawed frog  Xtro\nbn   Gallus gallus Domestic chicken  Ggal\NBN   Mus musculus House mouse  Mmus\Nbn   Rattus norvegicus Norway rat  Rnor\Nbn   Homo sapiens Human  Hsap\NBN
Human Orthologs (1)
Gene OMIM HGNC Hsap\NBN
AAA Orthologs (0) based on analysis using Dmel annotation version 4.3
No orthologs identified
Stocks & Reagents
Stocks Listed in FlyBase ( 7 )
Bloomington	21141 y1 w67c23; P{EPgy2}nbsEY15506 2554 nbs1 kniri-1 pp/TM3, Sb1 2557 nbs2 kniri-1 pp/TM3, Sb1
Kyoto	107399 nbs1 kniri-1 pp/TM3, Sb1 107401 nbs2 kniri-1 pp/TM3, Sb1
VDRC	v28215 w1118; P{GD12399}v28215 v28216 w1118; P{GD12399}v28216
Genomic Clones ( 2 )
	BACR02B01 BACR07E07 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 83 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	LD44438
Other clones
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	AT03327 AT05781 AT09710 AT31044 GH18430 GH18605 GM13403 LD22566 LD26919 LD27676 LD29727 LP13419 SD04620 SD07492
Other clones	214217.39 214377.35 CK01.16A.H10 CK01.86B.E9 Dmel_neb_013478_0940_1918 EC22637 EK015963 EK068217 EP10222 EP21347 FGM237E08 RP003016193 RP003051574 RP003067597 RP003102178 RP003106924 RP003129956 RP003131916 RP003167862 RP003176968 RP003214523 RP003236505 RP003246692 RP003265406 RP003281786 RP003286216 RP003293398 RP003297932 RP003301976 RP003306935 RP003311027 RP003314281 RP003333333 RP003338309 RP003342066 RP003343077 RP003352062 RP003357248 RP003412325 RP003435658 RP003449280 RP003458503 RP003461410 RP003462349 RP003464654 RP003475955 RP003479872 RP003481262 RP003487964 RP003517782 RP003520135 RP003525029 RP003526820 RP003539972 RP003568838 RP003574022 RP003593890 RP003600457 RP003606370 RP003607805 RP003609988 RP003618134 RP003631035 RP003636229 RP003642781 RP003671963 RP003677697 UUGC0722
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0261530 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 44259
Antibody Information
	polyclonal (Gao et al., 2009)
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of
Source for database merge of	Source for merge of: nbs CG6754 (Flores, 2000.6.9) Source for merge of: nbs l(3)67BDp (Ciapponi et al., 2006) Source for merge of: nbs l(3)67BDr (Oikemus et al., 2006)
Additional comments	FlyBase curator comment: the insertion in the "c06100" Exelixis line (PBac{PB}deflc06100) was originally assigned to the nbs gene in FBrf0179797, resulting in the "nbsc06100" (FBal0158901) allele. However, FBrf0184340 shows that the insertion is actually within defl. (Bloomington Drosophila Stock Center, 2004.11.6)
Other Comments
	nbs is required to maintain chromosome integrity and to prevent telomere fusion. nbs mediates transport of the mre11/rad50 complex in the nucleus. nbs and the mre11/rad50 complex play partially independent roles in telomere protection and nbs appears to function in both mei-41- and tefu-controlled telomere protection pathways. (Ciapponi et al., 2006) nbs is essential for cell cycle arrest at high doses of X-irradiation. (Oikemus et al., 2006) Identification: Defined on basis of DNA sequence similarity to NBS (Nijmegen Breakage Syndrome). (Flores and Engels, 1999)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_143716 NM_001259773 NM_001259774 RefSeq (Proteins) • NP_651973 NP_001246702 NP_001246703 DDBJ / EMBL / GenBank • AAF50215 AAL29026 AFH04373 AFH04374 AI512537 AW943722 AY061478 Entrez Gene - A searchable database of RefSeq genes. • 44259 UniProtKB/TrEMBL • Q9VT40 Q95RC6
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • SMAD/FHA domain (IPR008984) BRCT domain (IPR001357) Forkhead-associated (FHA) domain (IPR000253) Nibrin (IPR016592)
Linkouts
	DroID - A comprehensive database of gene and protein interactions. • FBgn0261530 DRSC - Results from RNAi screens. • FBgn0261530 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0086349 FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0261530 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 44259 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 44259 modMine - Data generated by the modENCODE project. • FBgn0261530 SignaLink - A protein-protein and protein-miRNA interaction database with multi-layered structure and multiple confidence scores. • Q9VT40
Synonyms & Secondary IDs ( 14 )
Reported As
Symbol Synonym	6754 (Ravi et al., 2009) CG6754 (Flores, 2000.6.9, Keleman et al., 2009.8.5) Dnbs1 (Rutkowski and Warren, 2009) l(3)67BDp (Ciapponi et al., 2006, Bi et al., 2005) l(3)67BDr (Oikemus et al., 2006) l(3)e77A1   nbs (Lafave and Sekelsky, 2011, Gao et al., 2008, Gao et al., 2009, Gao et al., 2009, Ciapponi et al., 2006, Oikemus et al., 2007, Bi et al., 2005, Rutkowski and Warren, 2009, Oikemus et al., 2006, Mavrich et al., 2008, Rong, 2008, Dronamraju and Mason, 2009, Gao et al., 2010, Kondo and Perrimon, 2011, Mukherjee et al., 2009) Nbs (Raffa et al., 2011, Kurzhals et al., 2011, Hochwagen, 2006, Gao et al., 2008) NBS (Dronamraju and Mason, 2009) Nbs1 (Bangash et al., 2005) NBS1 (Kondo and Perrimon, 2011)
Name Synonym	lethal (3) 67BDp   lethal (3) 67BDr   nbs   Nijmegen breakage syndrome (Bi et al., 2005, )
Secondary FlyBase IDs
	FBgn0002218 FBgn0002220 FBgn0026198 FBgn0036037 FBgn0086349
References ( 42 )
Generate a list of	All references relating to this gene ( 42 )
List References by type	Research paper  ( 19 ) Supplementary material  ( 4 ) Review  ( 1 ) Personal communication to FlyBase  ( 9 ) Abstract  ( 6 ) FlyBase analysis  ( 1 ) Book  ( 1 ) Curated genome annotation  ( 1 )
Recent research papers ( 5 )
	Beaucher et al., 2012, Genetics 191(2): 407--417 Multiple pathways suppress telomere addition to DNA breaks in the Drosophila germline. [FBrf0218640] Kondo and Perrimon, 2011, Sci. Signal. 4(154): rs1 A Genome-Wide RNAi Screen Identifies Core Components of the G2-M DNA Damage Checkpoint. [FBrf0212700] Kurzhals et al., 2011, PLoS Genet. 7(6): e1002103 Chk2 and p53 are haploinsufficient with dependent and independent functions to eliminate cells after telomere loss. [FBrf0216299] Lafave and Sekelsky, 2011, Genetics 188(3): 749--752 Transcription Initiation From Within P Elements Generates Hypomorphic Mutations in Drosophila melanogaster. [FBrf0214251] Raffa et al., 2011, Nucleus 2(5): 383--391 Terminin: A protein complex that mediates epigenetic maintenance of Drosophila telomeres. [FBrf0216520] Show all research papers ...
Recent reviews (0)
	All reviews listed in FlyBase were published before 2011 Show reviews ...