FlyBase Gene Report: Dmel\l(2)34Fc

General Information

Symbol

Dmel\l(2)34Fc

Species

D. melanogaster

Name

lethal (2) 34Fc

Annotation Symbol

CG7532

Feature Type

protein_coding_gene

FlyBase ID

FBgn0261534

Gene Model Status

Current

Stock Availability

12 publicly available

Gene Summary

May have antimicrobial activity. A late response immune regulated gene that is negatively regulated by spz during the immune response. (UniProt, Q9V3Y3)

Contribute a Gene Snapshot for this gene.

All Summaries

Alliance
Auto summary
UniProtKB
Interactive Fly

Also Known As

l(2)br8, BG:DS01068.5 , DS01068.5

Key Links

Genomic Location

Cytogenetic map

35A4-35A4

Sequence location

2L:14,349,020..14,351,513 [-]

Recombination map

2-50

RefSeq locus

NT_033779 REGION:14349020..14351513

Sequence

Get Decorated FASTA

Genomic Maps

JBrowse

Other Genome Views

The following external sites may use different assemblies or annotations than FlyBase.

Function

Gene Ontology (GO) Annotations (4 terms)

Molecular Function (0 terms)

Terms Based on Experimental Evidence (0 terms)

Terms Based on Predictions or Assertions (0 terms)

Biological Process (2 terms)

Terms Based on Experimental Evidence (2 terms)

CV Term

Evidence

References

involved_in defense response to protozoan

inferred from mutant phenotype

(De Gregorio et al., 2002)

involved_in negative regulation of immune response

inferred from mutant phenotype

(De Gregorio et al., 2002)

Terms Based on Predictions or Assertions (0 terms)

Cellular Component (2 terms)

Terms Based on Experimental Evidence (0 terms)

Terms Based on Predictions or Assertions (2 terms)

CV Term

Evidence

References

located_in extracellular region

inferred from sequence or structural similarity with UniProtKB:Q0Q029

(Gene Ontology Curators, 2002-)

is_active_in membrane

inferred from biological aspect of ancestor with PANTHER:PTN005253508

(GO Reference Genome Project, 2011-)

Gene Group (FlyBase)

Protein Family (UniProt)

Belongs to the insect defense protein family. (Q9V3Y3)

Protein Signatures (InterPro)

Summaries

Protein Function (UniProtKB)

May have antimicrobial activity. A late response immune regulated gene that is negatively regulated by spz during the immune response.

(UniProt, Q9V3Y3)

Gene Model and Products

Number of Transcripts

Number of Unique Polypeptides

Please see the JBrowse view of Dmel\l(2)34Fc for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)

Isoform displayed:

Pfam protein domains

InterPro name

classification

start

end

Protein Domains (via SMART)

Isoform displayed:

SMART protein domains

InterPro name

classification

start

end

Structure

Protein 3D structure (Predicted by AlphaFold) (AlphaFold entry Q9V3Y3)

If you don't see a structure in the viewer, refresh your browser.

Model Confidence:

Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Experimentally Determined Structures

Crossreferences

Comments on Gene Model

Gene model reviewed during 5.52

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Assoc. CDS (aa)

l(2)34Fc-RA

FBtr0080640

NM_135866

656

159

l(2)34Fc-RB

FBtr0343680

NM_001299001

733

159

Additional Transcript Data and Comments

Reported size (kB)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kDa)

Length (aa)

Theoretical pI

UniProt

RefSeq ID

GenBank

l(2)34Fc-PA

FBpp0080212

17.2

159

8.48

FBpp0310269

17.2

159

8.48

Q9V3Y3

NP_001285930

AHN54444

Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

159 aa isoforms: l(2)34Fc-PA, l(2)34Fc-PB

Additional Polypeptide Data and Comments

Reported size (kDa)

Comments

External Data

Crossreferences

InterPro - A database of protein families, domains and functional sites

Linkouts

Sequences Consistent with the Gene Model

Nucleotide / Polypeptide Records

UniProt

Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\l(2)34Fc using the Feature Mapper tool.

External Data

Crossreferences

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

l(2)34Fc_1

Linkouts

Expression Data

Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

-0.61

Transcript Expression

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Polypeptide Expression

mass spectroscopy

Stage

Tissue/Position (including subcellular localization)

Reference

adult stage

adult head

• membrane

(Aradska et al., 2015)

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Evidence

References

Expression Deduced from Reporters

High-Throughput Expression Data

Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\l(2)34Fc in JBrowse

RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region

View exonic expression by developmental stage for Dmel\l(2)34Fc

View exonic expression by tissue for Dmel\l(2)34Fc

Bulk Downloads

RNA-Seq RPKM values for all genes

Reference

See Gelbart and Emmert, 2013 for analysis details and data files for all genes.

Developmental Proteome: Life Cycle

Developmental Proteome: Embryogenesis

External Data and Images

Linkouts

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

34838/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0261534

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0028915

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0261534

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG7532

Images

FlyBase Wiki

Image Based Resources

Alleles, Insertions, Transgenic Constructs, and Aberrations

Classical and Insertion Alleles ( 16 )

For All Classical and Insertion Alleles Show

Other relevant insertions

Transgenic Constructs ( 4 )

For All Alleles Carried on Transgenic Constructs Show

Transgenic constructs containing/affecting coding region of l(2)34Fc

Transgenic constructs containing regulatory region of l(2)34Fc

Aberrations (Deficiencies and Duplications) ( 139 )

Inferred from experimentation ( 139 )

Gene not disrupted in

Df(2L)A48

(Roote et al., 1996, Fossett et al., 1994, Gubb et al., 1990, Ashburner et al., 1982, Ashburner et al., 1982)

Df(2L)A63

(Roote et al., 1996, Fossett et al., 1994, Ashburner et al., 1982, Ashburner et al., 1982)

Df(2L)A72

(Fossett et al., 1994, Ashburner et al., 1982, Ashburner et al., 1982)

Df(2L)A178

(Roote et al., 1996, Fossett et al., 1994, Ashburner et al., 1982, Ashburner et al., 1982)

Df(2L)A220

(Fossett et al., 1994, Ashburner et al., 1982)

Df(2L)A245

(Roote et al., 1996, Fossett et al., 1994, Ashburner et al., 1982)

Df(2L)A260

(Ashburner et al., 1982)

Df(2L)A264

(Fossett et al., 1994, Ashburner et al., 1982)

Df(2L)A266

(Fossett et al., 1994, Ashburner et al., 1982, Ashburner et al., 1982)

Df(2L)A267

(Roote et al., 1996, Fossett et al., 1994, Ashburner et al., 1982, Ashburner et al., 1982)

Df(2L)A379

(Fossett et al., 1994, Ashburner et al., 1982, Ashburner et al., 1982)

Df(2L)A400

(Roote et al., 1996, Fossett et al., 1994, Ashburner et al., 1982, Ashburner et al., 1982)

Df(2L)A445

(Roote et al., 1996, Fossett et al., 1994, Ashburner et al., 1982)

Df(2L)Adh-nBR102

(Roote et al., 1996, Fossett et al., 1994)

Df(2L)Adh-nBR105

(Fossett et al., 1994)

Df(2L)Adh-nBR106

(Fossett et al., 1994)

Df(2L)Adh-nBR107

(Fossett et al., 1994)

Df(2L)Adh-nBR118

(Fossett et al., 1994)

Df(2L)Adh-nBR119

(Fossett et al., 1994)

Df(2L)Adh-nBR121

(Fossett et al., 1994)

Df(2L)Adh-nBR122

(Fossett et al., 1994)

Df(2L)Adh-nBR126

(Fossett et al., 1994)

Df(2L)Adh-nBR127

(Fossett et al., 1994)

Df(2L)Adh-nBR128

(Fossett et al., 1994)

Df(2L)Adh-nBR129

(Fossett et al., 1994)

Df(2L)ARR1

(Roote et al., 1996)

Df(2L)b75

(Gubb et al., 1990, Woodruff and Ashburner, 1979)

Df(2L)b78j

(Roote, 2009.11.24)

Df(2L)ED8185

(Roote, 2009.11.24, Roote, 2009.11.24)

Df(2L)ED8186

(Roote, 2009.11.24, Roote, 2009.11.24)

Df(2L)el14

(Roote et al., 1996)

Df(2L)fn2

(Roote et al., 1996, Ashburner et al., 1982, Ashburner et al., 1982, Woodruff and Ashburner, 1979, O'Donnell et al., 1977)

Df(2L)fn3

(Ashburner et al., 1982, Woodruff and Ashburner, 1979, O'Donnell et al., 1977)

Df(2L)fn15

(Ashburner et al., 1982, O'Donnell et al., 1977)

Df(2L)fn27

(Ashburner et al., 1982, Ashburner et al., 1982, O'Donnell et al., 1977)

Df(2L)k08712-rv21

(Roote, 2009.11.24)

Df(2L)k08712-rv34

(Roote, 2009.11.24)

Df(2L)n78l3

(Ashburner et al., 1982)

Df(2L)osp29

(Roote et al., 1996, Ashburner et al., 1982)

Df(2L)osp144

(Roote et al., 1996, Ashburner et al., 1982)

Df(2L)Sco^rv4

(Woodruff and Ashburner, 1979)

Df(2L)TE35B-1

(Gubb et al., 1985)

Df(2L)TE35B-6

(Gubb et al., 1985)

Df(2L)TE35B-7

(Roote et al., 1996, Gubb et al., 1985)

Df(2L)TE35B-11

(Roote et al., 1996, Gubb et al., 1985)

Df(2L)TE35B-12

(Roote et al., 1996, Gubb et al., 1985)

Df(2L)TE35B-54^L

(Roote et al., 1996)

Df(2L)TE35BC-1

(Gubb et al., 1984)

Df(2L)TE35BC-3

(Gubb et al., 1984, Ashburner et al., 1982)

Df(2L)TE35BC-4

(Roote et al., 1996, Gubb et al., 1984, Ashburner et al., 1982)

Df(2L)TE35BC-7

(Gubb et al., 1984)

Df(2L)TE35BC-8

(Gubb et al., 1984)

Df(2L)TE35BC-24

(Gubb et al., 1984)

Df(2L)TE35BC-28

(Gubb et al., 1984)

Df(2L)TE35BC-34

(Gubb et al., 1984)

Df(2L)TE35BC-35

(Gubb et al., 1984)

Dp(2;2)Cam12

(Roote et al., 1996)

In(2L)TE35B-13

(Gubb et al., 1985)

In(2LR)el^6LA379^R

(Roote et al., 1996)

T(2;3)Sco^rv7

(Woodruff and Ashburner, 1979)

T(2;4)GT6

(Roote, 1999.6.8)

T(Y;2)A80^DR15^P

(Ashburner et al., 1982, Woodruff and Ashburner, 1979)

T(Y;2)J165^DP58^P

(Woodruff and Ashburner, 1979)

T(Y;2)R15^DJ165^P

(Woodruff and Ashburner, 1979)

Tp(2;2)A446

(Roote et al., 1996, Fossett et al., 1994, Ashburner et al., 1982, Ashburner et al., 1982)

Ts(2Lt;3Lt)dpp^s19+Ts(2Rt;3Rt)el24

(Roote et al., 1996)

Ts(2Lt;3Lt)TE35B-28+Ts(2Rt;3Rt)osp⁹⁰

(Roote et al., 1996)

Ts(2Lt;3Rt)GT10+Ts(2Rt;3Lt)TE35B-209

(Roote et al., 1996)

Ts(Y;2Lt)el⁴+Ts(YSt;2Rt)A80

(Roote et al., 1996)

Ts(Y;2Lt)el⁴+Ts(YSt;2Rt)R15

(Roote et al., 1996, Ashburner et al., 1982)

Ts(Y;2Lt)GT2+Ts(YSt;2Rt)A80

(Roote et al., 1996)

Gene not duplicated in

Dp(2;2)TE35B-54^L

(Roote et al., 1996)

Dp(2;3)osp³

(Roote et al., 1996)

In(2L)C163.41^LC158^R

(Roote et al., 1996)

In(2LR)TE35B-226^LDTD128^R

(Roote et al., 1996)

Ts(Y;2Lt)TE35B-18+Ts(YSt;2Rt)A80

(Roote et al., 1996)

Ts(YLt;2Lt)A80+Ts(Y;2Rt)el⁴

(Roote et al., 1996)

Ts(YLt;2Lt)R15+Ts(Y;2Rt)el⁴

(Roote et al., 1996)

Ts(YLt;2Lt)R15+Ts(Y;2Rt)TE35B-18

(Roote et al., 1996)

Ts(YLt;2Lt)R15+Ts(YSt;2Rt)A80

(Roote et al., 1996)

Gene disrupted in

Df(2L)64j

(Woodruff and Ashburner, 1979, O'Donnell et al., 1977)

Df(2L)A47

(Roote et al., 1996, Fossett et al., 1994, Gubb et al., 1990, Ashburner et al., 1982)

Df(2L)A215

(Fossett et al., 1994, Ashburner et al., 1982)

Df(2L)A217

(Roote et al., 1996, Fossett et al., 1994, Ashburner et al., 1982)

Df(2L)A246

(Fossett et al., 1994, Ashburner et al., 1982)

Df(2L)A263

(Ashburner et al., 1982)

Df(2L)A337

(Fossett et al., 1994)

Df(2L)A376

(Fossett et al., 1994, Ashburner et al., 1982)

Df(2L)A377

(Ashburner et al., 1982)

Df(2L)Adh-nBR100

(Fossett et al., 1994)

Df(2L)Adh-nBR101

(Fossett et al., 1994)

Df(2L)Adh-nBR103

(Fossett et al., 1994)

Df(2L)Adh-nBR117

(Fossett et al., 1994)

Df(2L)Adh-nBR120

(Fossett et al., 1994)

Df(2L)Adh-nBR125

(Fossett et al., 1994)

Df(2L)Adh-nBR130

(Fossett et al., 1994)

Df(2L)Adh-nBR131

(Fossett et al., 1994)

Df(2L)b80e3

(Roote et al., 1996, Ashburner et al., 1982)

Df(2L)b81a1

(Roote et al., 1996, Ashburner et al., 1982)

Df(2L)b83d29a

(Roote et al., 1996)

Df(2L)b84a2

(Roote et al., 1996)

Df(2L)b84a4

(Roote et al., 1996)

Df(2L)b88h49

(Roote et al., 1996)

Df(2L)do1

(Roote, 1996.8)

Df(2L)el77

(Woodruff and Ashburner, 1979)

Df(2L)EP(2)2039-rv4

(Roote, 2000.6.13)

Df(2L)Exel6035

(Ryder, 2004.4.26)

Df(2L)fn1

(Ashburner et al., 1982, Ashburner et al., 1982, Woodruff and Ashburner, 1979, O'Donnell et al., 1977)

Df(2L)fn5

(Ashburner et al., 1982, O'Donnell et al., 1977)

Df(2L)fn7

(Ashburner et al., 1982, Woodruff and Ashburner, 1979, O'Donnell et al., 1977)

Df(2L)fn12

(Ashburner et al., 1982, Woodruff and Ashburner, 1979, O'Donnell et al., 1977)

Df(2L)fn26

(Ashburner et al., 1982, O'Donnell et al., 1977)

Df(2L)fn30

(Ashburner et al., 1982, O'Donnell et al., 1977)

Df(2L)fn31

(Ashburner et al., 1982, O'Donnell et al., 1977)

Df(2L)fn36

(Ashburner et al., 1982, O'Donnell et al., 1977)

Df(2L)GT4

(Gubb et al., 1990)

Df(2L)GT5

(Gubb et al., 1990)

Df(2L)TE35B-2

(Gubb et al., 1985)

Df(2L)TE35B-3

(Gubb et al., 1985)

Df(2L)TE35B-4

(Gubb et al., 1985)

Df(2L)TE35B-5

(Gubb et al., 1985)

Df(2L)TE35B-8

(Roote et al., 1996, Gubb et al., 1985)

Df(2L)TE35B-9

(Gubb et al., 1985)

Df(2L)TE35B-10

(Gubb et al., 1985)

Df(2L)TE35B-15

(Gubb et al., 1985)

Df(2L)TE35B-300

(Roote et al., 1996)

Df(2L)TE35BC-6

(Gubb et al., 1984)

Df(2L)TE35BC-23

(Gubb et al., 1984)

Df(2L)TE35BC-29

(Gubb et al., 1984)

Df(2L)TE35BC-31

(Gubb et al., 1984)

Df(2L)W

(Ashburner et al., 1982, Woodruff and Ashburner, 1979)

In(2L)75c^LC158.1^R

(Woodruff and Ashburner, 1979)

In(2L)75c

(Woodruff and Ashburner, 1979)

In(2LR)D20^Lnoc^4R

(Roote et al., 1996)

T(2;3)GT10

(Ashburner et al., 1999.10.12, Gubb et al., 1990)

T(2;4)GT6

(Gubb et al., 1990)

Ts(2Lt;4Lt)GT6+Ts(2Rt;4Rt)TE35B-101

(Roote et al., 1996, Roote, 1995.3.27)

Gene duplicated in

Ts(2Lt;4Lt)TE35B-101+Ts(2Rt;4Rt)GT6

(Roote et al., 1996)

Ts(YLt;2Lt)A80+Ts(YLt;2Rt)G74

(Roote et al., 1996)

Gene partially disrupted in

Ts(2Lt;3Rt)GT10+Ts(2Rt;3Lt)TE35BC-8

(Ashburner et al., 1999.10.12)

Inferred from location ( 7 )

Variants

Variant Molecular Consequences

Alleles Representing Disease-Implicated Variants

Phenotypes

For more details about a specific phenotype click on the relevant allele symbol.

Lethality

Allele

lethal | recessive

viable, with Scer\GAL4^Mef2.PR

l(2)34Fc^GD5397

viable, with Scer\GAL4^pnr-MD237

l(2)34Fc^GD5397

Phenotype manifest in

Allele

Orthologs

Downloads

Download All DIOPT Orthologs

Human Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Homo sapiens (Human) (3)

Hsap\FRRS1

5 of 14

Yes

Hsap\REELD1

4 of 14

Hsap\FRRS1L

1 of 14

Model Organism Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Rattus norvegicus (Norway rat) (2)

Rnor\Frrs1

5 of 14

Yes

Rnor\Frrs1l

1 of 14

Mus musculus (laboratory mouse) (2)

Mmus\Frrs1

5 of 14

Yes

Mmus\Frrs1l

1 of 14

Xenopus tropicalis (Western clawed frog) (8)

Xtro\frrs1

4 of 13

Yes

Xtro\LOC100489839

2 of 13

Xtro\reeld1

2 of 13

Xtro\amigo1

1 of 13

Yes

Xtro\cacna1s

1 of 13

Xtro\LOC100491943

1 of 13

Xtro\LOC105947222

1 of 13

Yes

Xtro\slc25a17

1 of 13

Danio rerio (Zebrafish) (12)

Drer\si:dkey-251i10.2

8 of 14

Yes

5 of 14

4 of 14

4 of 14

3 of 14

Yes

Drer\si:ch73-14h1.2

3 of 14

Drer\LOC110440009

2 of 14

Drer\si:ch73-196i15.3

2 of 14

Yes

Drer\si:ch73-196i15.5

2 of 14

Yes

Drer\frrs1l

1 of 14

Drer\spon1a

1 of 14

Drer\spon1b

1 of 14

Caenorhabditis elegans (Nematode, roundworm) (9)

Cele\F23B12.4

4 of 14

Yes

3 of 14

3 of 14

2 of 14

2 of 14

2 of 14

1 of 14

1 of 14

1 of 14

Anopheles gambiae (African malaria mosquito) (4)

Agam\AgaP_AGAP008878

7 of 12

Yes

Agam\AgaP_AGAP005170

2 of 12

Agam\AgaP_AGAP004599

1 of 12

Agam\AgaP_AGAP005169

1 of 12

Arabidopsis thaliana (thale-cress) (0)

Saccharomyces cerevisiae (Brewer's yeast) (0)

Schizosaccharomyces pombe (Fission yeast) (0)

Escherichia coli (enterobacterium) (0)

Other Organism Orthologs (via OrthoDB)

Data provided directly from OrthoDB:l(2)34Fc. Refer to their site for version information.

Paralogs

Downloads

Download All DIOPT Paralogs

Paralogs (via DIOPT v9.1)

Gene Symbol

Score

Source

Alignment

Drosophila melanogaster (Fruit fly) (2)

CG8399

4 of 13

CG14515

3 of 13

Human Disease Associations

FlyBase Human Disease Model Reports

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Allele

Disease

Evidence

References

Potential Models Based on Orthology ( 0 )

Human Ortholog

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Allele

Disease

Interaction

References

Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)

Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.

Homo sapiens (Human)

Gene name

Score

OMIM

OMIM Phenotype

DO term

Complementation?

Transgene?

FRRS1; ferric chelate reductase 1

5 of 14

611578

REELD1; reeler domain containing 1

4 of 14

Functional Complementation Data

Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.

Interactions

Summary of Physical Interactions

esyN Network Diagram

Other Interaction Browsers

Summary of Genetic Interactions

esyN Network Diagram

Other Interaction Browsers

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

External Data

Linkouts

DroID - A comprehensive database of gene and protein interactions.

FBgn0261534

Pathways

Signaling Pathways (FlyBase)

Metabolic Pathways

FlyBase

External Links

External Data

Linkouts

Class of Gene

gene

nuclear_gene

protein_coding_gene

Genomic Location and Detailed Mapping Data

Chromosome (arm)

Recombination map

2-50

Cytogenetic map

35A4-35A4

Sequence location

2L:14,349,020..14,351,513 [-]

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

35A4-35A4

Limits computationally determined from genome sequence between P{lacW}l(2)34Fa^k00811&P{PZ}wb⁰⁹⁴³⁷ and P{EP}elB^EP2039&P{PZ}osp^rJ571

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

Experimentally Determined Recombination Data

Location

2-50

(FlyBase, 2016)

2-46.2

(Comeron et al., 2012)

2-[49]

Left of (cM)

(Woodruff and Ashburner, 1979)

Right of (cM)

Notes

Excisions of Rab14^k08712 show that the gene order is ms(2)34Fe, l(2)34Fd, Rab14, Pgant35A.

(Ashburner et al., 1999.10.12)

Maps 0.19cM to the left of Tp(2;2)Sco.

(Woodruff and Ashburner, 1979)

Stocks and Reagents

Stocks (12)

Aberrations including deletions of this gene Aberrations including duplications of this gene

Bloomington

25221

w¹¹¹⁸; Mi{ET1}l(2)34Fc^MB05436

28419

y¹ w^*; P{EP}l(2)34Fc^G18904

25144

Adc^b-1 l(2)34Fc³ Adhⁿ² pr¹ cn¹/CyO

56023

y¹ sc^* v¹ sev²¹; P{TRiP.HMC04319}attP40/CyO

3774

Adc^b-1 l(2)34Fc⁶ Adhⁿ⁴/In(2L)Cy, In(2R)Cy, Duox^Cy Bl¹ cn²

Kyoto

101314

Adc^b-1 l(2)34Fc⁶ Adhⁿ⁴ / CyO, Duox^Cy dpy^lv1 pr¹ cn²

NIG-Fly

7532R-1

P{NIG.7532R}1

M2L-1708

y¹ w¹¹¹⁸; l(2)34Fc^SK1 P{neoFRT}40A/CyO-Tb

M2L-1709

y¹ w¹¹¹⁸; l(2)34Fc^SK2 P{neoFRT}40A/CyO-Tb

2LG-1209

y² VhaAC39-1^cho-1 v¹; P{U6-l(2)34Fc.NIG.sgRNA}attP40/CyO

VDRC

v12405

w¹¹¹⁸; P{GD5397}v12405

v13490

w¹¹¹⁸; P{GD5397}v13490/CyO

Genomic Clones (17)

Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

cDNA Clones (24)

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequenced

BDGP DGC clones

Other clones

DPiM_RE60882

Drosophila Genomics Resource Center cDNA clones

For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

FBgn0261534

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

Other clones

RNAi and Array Information

Linkouts

DRSC - Results frm RNAi screens

FBgn0261534

Antibody Information

Laboratory Generated Antibodies

Commercially Available Antibodies

Cell Line Information

Publicly Available Cell Lines

Other Stable Cell Lines

Other Comments

Relationship to Other Genes

Source for database merge of

Source for merge of: BG:DS01068.5 anon- EST:ParkEST060

(Bayraktaroglu, 2000.11.2)

Source for merge of: l(2)34Fc CG7532

(Roote, 2009.11.24)

Source for merge of: CG7532 BcDNA:RE60882

(FlyBase, 1996-)

Additional comments

" BG:DS01068.1 ", " BG:DS01068.2 ", " BG:DS01068.10 ", " BG:DS01068.4 ", " BG:DS01068.5 " or " BG:DS01068.11 " may correspond to "l(2)34Fc".

(Ashburner et al., 1999.10.12)

" BG:DS01068.5 " may correspond to "ms(2)34Fe", "l(2)34Fc" or "l(2)34Fd".

(Ashburner et al., 1999.10.12)

Source for merge of CG7532 BcDNA:RE60882 was a shared cDNA ( date:030728 ).

(FlyBase, 1996-)

Nomenclature History

Source for database identify of

Source for identity of: BG:DS01068.5 CG7532

(Kodira, 1999.11)

Nomenclature comments

Etymology

Synonyms and Secondary IDs (13)

Reported As

Symbol Synonym

(O'Donnell et al., 1977)

BG:DS01068.5

(Ashburner et al., 1999, Ashburner et al., 1999, Ashburner et al., 1999.10.12)

BcDNA:RE60882

CG7532

(National Institute of Genetics Fly Stocks, 2022-, Çiçek et al., 2016, Icreverzi et al., 2015, Felix et al., 2012, Japanese National Institute of Genetics, 2012.5.21, Ni et al., 2010.12.1, Roote, 2009.11.24, McGraw et al., 2008)

DS01068.5

(Schmid and Aquadro, 2001, Reese et al., 2000)

anon-EST:ParkEST060

br8

(Gubb et al., 1985)

l(2)34Fc

(Zhou et al., 2021, Felix et al., 2012, Roote, 2009.11.24, Roote, 2009.11.24)

l(2)br8

(The Moscow Regional Drosophila melanogaster Stock Center, Dubna, Gubb et al., 1984, Ashburner et al., 1982, Ashburner et al., 1982, Woodruff and Ashburner, 1979)

l34Fc

(Fossett et al., 1994)

Name Synonyms

lethal (2) 34Fc

lethal 8 in the black-reduced region

(Woodruff and Ashburner, 1979)

lethal group A2

(O'Donnell et al., 1977)

Secondary FlyBase IDs

FBgn0001968
FBgn0028915
FBgn0026299
FBgn0062987

Datasets (0)

Study focus (0)

Experimental Role

Project

Project Type

Title

Study result (0)

Result

Result Type

Title

External Crossreferences and Linkouts ( 36 )

Sequence Crossreferences

NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.

34838

GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.

GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.

RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.

UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.

Q9V3Y3

UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information

Q9V3Y3

UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information

X2J8E8

Other crossreferences

AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.

Q9V3Y3

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

34838/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0261534

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0261534

InterPro - A database of protein families, domains and functional sites

KEGG Genes - Molecular building blocks of life in the genomic space.

dme:Dmel_CG7532

MARRVEL_MODEL - MARRVEL (model organism gene)

34838

Linkouts

Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones

FBgn0261534

DroID - A comprehensive database of gene and protein interactions.

FBgn0261534

DRSC - Results frm RNAi screens

FBgn0261534

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

l(2)34Fc_1

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0028915

FlyCyc Genes - Genes from a BioCyc PGDB for Dmel

FBGN0261534

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG7532

iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)

TC013059

References (63)

The following external sites may use different assemblies or annotations than FlyBase.

-0.61

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