DAG kinase, DGK
Alternative translation stop created by use of multiphasic reading frames within coding region.
Gene model reviewed during 5.46
Gene model reviewed during 5.53
Gene model reviewed during 6.32
9.0 (northern blot)
None of the polypeptides share 100% sequence identity.
1454 (aa); 116 (kD predicted)
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\rdgA using the Feature Mapper tool.
GBrowse - Visual display of RNA-Seq signalsView Dmel\rdgA in GBrowse 2
Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R+ cell morphology.
RNAi screen using dsRNA made from templates generated with primers directed against this gene causes a phenotype when assayed in Kc167 and S2R+ cells: increased or polarized (uneven) accumulation of F-actin.
The eye specific form of diacylglycerol (DAG) kinase (encoded by rdgA) is involved in the resynthesis of DAG which is essential for production of phosphatidylinositol-4,5-biphosphate (PtdInsP2) needed for signal transduction.
Photoreceptors degenerate during first week of adult life, although electroretinogram is small at time of eclosion when photoreceptors are morphologically normal.
Degeneration of compound eye photoreceptors is not light- or temperature-dependent, such degeneration is photoreceptor-autonomous in mosaics.
Degeneration of compound eye photoreceptors is photoreceptor-autonomous in mosaics.