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Gene Dmel\CG42668

General Information
Symbol	Dmel\CG42668	Species	D. melanogaster
Name		Annotation symbol	CG42668
Feature type	protein_coding_gene	FlyBase ID	FBgn0261550
Gene Model Status	Current	Stock availability	7 publicly available
Also Known As	CG5077
Genomic Location
Chromosome (arm)	3R	Recombination map
Cytogenetic map	92E2-92E2	Sequence location	3R:16,135,263..16,149,918 [+]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents modENCODE GBrowse	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	This gene is referred to in FlyBase by the symbol Dmel\CG42668 (FBgn0261550). It is a protein_coding_gene from Drosophila melanogaster. Based on sequence similarity, it is predicted to have molecular function: oxysterol binding. The biological processes in which it is involved are not known. 8 alleles are reported. No phenotypic data is available. It has 9 annotated transcripts and 9 annotated polypeptides. Protein features are: Oxysterol-binding protein; Oxysterol-binding protein, conserved site; Pleckstrin homology domain; Pleckstrin homology-type. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of low expression. Peak expression observed within 00-06 and 12-24 hour embryonic stages, during early larval stages, at stages throughout the pupal period, in stages of adults of both sexes. Summary of FlyAtlas Anatomical Expression Data: Two or more Affy2 ProbeSets identify exons of this gene. This is a summary of the tissue expression peaks exhibited in at least one of these ProbeSets. Expression at high levels in the following post-embryonic organs or tissues: adult central nervous system. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, adult eye, larval central nervous system, adult crop, larval/adult midgut, larval/adult hindgut, larval/adult Malpighian tubules, adult heart, adult fat body, adult salivary gland, larval trachea, adult female reproductive system, adult male accessory gland, larval/adult carcass. Gene sequence location is 3R:16135263..16149918.
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2011_10	Controlled Vocabulary Terms day 42 of adulthood day 41 of adulthood day 30 of adulthood day 49 of adulthood day 17 of adulthood day 45 of adulthood day 6 of adulthood day 5 of adulthood day 8 of adulthood day 26 of adulthood day 21 of adulthood day 13 of adulthood day 25 of adulthood day 22 of adulthood day 20 of adulthood day 39 of adulthood day 7 of adulthood day 36 of adulthood day 11 of adulthood day 37 of adulthood day 27 of adulthood day 18 of adulthood day 19 of adulthood day 28 of adulthood day 9 of adulthood day 29 of adulthood adult heart day 40 of adulthood day 16 of adulthood day 24 of adulthood day 15 of adulthood day 33 of adulthood day 43 of adulthood day 47 of adulthood day 38 of adulthood day 32 of adulthood day 48 of adulthood day 35 of adulthood day 23 of adulthood day 12 of adulthood day 10 of adulthood day 31 of adulthood spermatozoon day 34 of adulthood day 44 of adulthood day 14 of adulthood male day 46 of adulthood
FB2012_01	Sequence features BKN31315 BKN28193 HFA15712
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 92E2-92E2   Limits computationally determined from genome sequence between P{PZ}l(3)1058510585 and P{EP}SyndEP409
Experimentally Determined Cytological Location
Cytogenetic map Notes References
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\CG42668 for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
	Gene merge based on RNAseq data.
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) CG42668-RD FBtr0302666  NM_169894   2092   625 CG42668-RE FBtr0302668  NM_001144614   3798   957 CG42668-RF FBtr0302669  NM_169892   3321   798 CG42668-RG FBtr0302670  NM_169893   3747   958 CG42668-RH FBtr0302667  NM_142621   3375   816 CG42668-RK FBtr0302673  NM_001202322   4280   956 CG42668-RL FBtr0303586  NM_001202323   4007   956 CG42668-RM FBtr0306633     4145   990 CG42668-RN FBtr0306634     3324   817
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein CG42668-PD   FBpp0291806   70.3   625   7.15     NP_732501   AAN13827 CG42668-PE   FBpp0291808   107.2   957   8.31     NP_001138086   ACL83542 CG42668-PF   FBpp0291809   89.5   798   8.12     NP_732499   AAN13825 CG42668-PG   FBpp0291810   107.3   958   8.31     NP_732500   AAN13826 CG42668-PH   FBpp0291807   91.6   816   7.83     NP_650878   AAG22160 CG42668-PK   FBpp0291813   104.6   956   7.98     NP_001189251   ADV37342 CG42668-PL   FBpp0292619   104.6   956   7.98     NP_001189252   ADV37343 CG42668-PM   FBpp0297588   108.3   990   8.39       CG42668-PN   FBpp0297589   91.7   817   7.83
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Oxysterol-binding protein (IPR000648) Pleckstrin homology domain (IPR001849) Pleckstrin homology-type (IPR011993) Oxysterol-binding protein, conserved site (IPR018494)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AE014297 AAG22160   AE014297 AAN13825   AE014297 AAN13826   AE014297 AAN13827   AE014297 ACL83542   AE014297 ADV37342   AE014297 ADV37343   AI063542   AI293514   AI405834   AI944454   AW941003   AY051614 AAK93038   BF488079   BF489483   BF490262   BF496742   BG633911   BG639570   BI352641   BI355695   BI567480   BI576395   BI582679   BI585989   BI586276   BI606487   BI621768   BT003800   BT011470   BT099594   BT099929   CA804829   CK658723   CO176796   CO271973   CO272713   CO273453   CO286133   CO290508   CO294665   CO302204   CO305966   CO323084   CO323308   CO326906   CO328258   CO340566   EC060160   EC065127   EC065493   EC080146   EC086487   EC200702   EC202458   EC209140   EC209242   EC214833   EC223565   EC226758   EC227564   EC230361   EC232471   EC237914   EC240639   EC247267   EC257062
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL	B7Z0M9 Q9VDN5 Q7KSB3 Q8IN55 Q8IN56 Q9I7I8
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
Polypeptide Expression
mass spectroscopy Stage Tissue/Position (including subcellular localization) Reference day 5 of adulthood & male -- day 7 of adulthood & male   spermatozoon   (Wasbrough et al., 2010) day 7 of adulthood -- day 49 of adulthood   adult heart   (Cammarato et al., 2011)
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
High-Throughput Expression Data
or
See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes. modENCODE Temporal Expression Data for FBgn0261550    Styles Linear Logarithmic Heatmap    Scales max expr for FBgn0261550 Very low expression bin max Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of low expression. Peak expression observed within 00-06 and 12-24 hour embryonic stages, during early larval stages, at stages throughout the pupal period, in stages of adults of both sexes. [download data (TSV)] Guide to modENCODE expression level colors   No expression (0 - 0)   Extremely low expression (1 - 10)   Very low expression (11 - 100)   Low expression (101 - 400)   Moderate expression (401 - 1400)   Moderately high expression (1401 - 4000)   High expression (4001 - 10000)   Very high expression (10001 - 100000)   Extremely high expression (100001 - 2000000) Linear, scaled to maximum FBgn0261550 expression level Developmental Stage   Expression Level embryo 00-02hr    2498 embryo 02-04hr    1274 embryo 04-06hr    237 embryo 06-08hr    532 embryo 08-10hr    639 embryo 10-12hr    1379 embryo 12-14hr    1288 embryo 14-16hr    1736 embryo 16-18hr    1839 embryo 18-20hr    2384 embryo 20-22hr    2293 embryo 22-24hr    2129 larva L1    1563 larva L2    1094 larva L3 12hr old    1119 larva L3 puffstage 1-2    851 larva L3 puffstage 3-6    909 larva L3 puffstage 7-9    878 white prepupae new    938 white prepupae 12hr    1736 white prepupae 24hr    1982 pupae 2d postWPP    1926 pupae 3d postWPP    1824 pupae 4d postWPP    2695 adult male 01day    2816 adult male 05day    3512 adult male 30day    3692 adult female 01day    1760 adult female 05day    1862 adult female 30day    2053 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High  Linear, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (2498) embryo 02-04hr  (1274) embryo 04-06hr  (237) embryo 06-08hr  (532) embryo 08-10hr  (639) embryo 10-12hr  (1379) embryo 12-14hr  (1288) embryo 14-16hr  (1736) embryo 16-18hr  (1839) embryo 18-20hr  (2384) embryo 20-22hr  (2293) embryo 22-24hr  (2129) larva L1  (1563) larva L2  (1094) larva L3 12hr old  (1119) larva L3 puffstage 1-2  (851) larva L3 puffstage 3-6  (909) larva L3 puffstage 7-9  (878) white prepupae new  (938) white prepupae 12hr  (1736) white prepupae 24hr  (1982) pupae 2d postWPP  (1926) pupae 3d postWPP  (1824) pupae 4d postWPP  (2695) adult male 01day  (2816) adult male 05day  (3512) adult male 30day  (3692) adult female 01day  (1760) adult female 05day  (1862) adult female 30day  (2053) Expression Level Scale  None   Extremely low   Very low   Low  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (2498) embryo 02-04hr    1274 embryo 04-06hr    237 embryo 06-08hr    532 embryo 08-10hr    639 embryo 10-12hr    1379 embryo 12-14hr    1288 embryo 14-16hr  (1736) embryo 16-18hr  (1839) embryo 18-20hr  (2384) embryo 20-22hr  (2293) embryo 22-24hr  (2129) larva L1  (1563) larva L2    1094 larva L3 12hr old    1119 larva L3 puffstage 1-2    851 larva L3 puffstage 3-6    909 larva L3 puffstage 7-9    878 white prepupae new    938 white prepupae 12hr  (1736) white prepupae 24hr  (1982) pupae 2d postWPP  (1926) pupae 3d postWPP  (1824) pupae 4d postWPP  (2695) adult male 01day  (2816) adult male 05day  (3512) adult male 30day  (3692) adult female 01day  (1760) adult female 05day  (1862) adult female 30day  (2053) Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    2498 embryo 02-04hr    1274 embryo 04-06hr    237 embryo 06-08hr    532 embryo 08-10hr    639 embryo 10-12hr    1379 embryo 12-14hr    1288 embryo 14-16hr    1736 embryo 16-18hr    1839 embryo 18-20hr    2384 embryo 20-22hr    2293 embryo 22-24hr    2129 larva L1    1563 larva L2    1094 larva L3 12hr old    1119 larva L3 puffstage 1-2    851 larva L3 puffstage 3-6    909 larva L3 puffstage 7-9    878 white prepupae new    938 white prepupae 12hr    1736 white prepupae 24hr    1982 pupae 2d postWPP    1926 pupae 3d postWPP    1824 pupae 4d postWPP    2695 adult male 01day    2816 adult male 05day    3512 adult male 30day    3692 adult female 01day    1760 adult female 05day    1862 adult female 30day    2053 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    2498 embryo 02-04hr    1274 embryo 04-06hr    237 embryo 06-08hr    532 embryo 08-10hr    639 embryo 10-12hr    1379 embryo 12-14hr    1288 embryo 14-16hr    1736 embryo 16-18hr    1839 embryo 18-20hr    2384 embryo 20-22hr    2293 embryo 22-24hr    2129 larva L1    1563 larva L2    1094 larva L3 12hr old    1119 larva L3 puffstage 1-2    851 larva L3 puffstage 3-6    909 larva L3 puffstage 7-9    878 white prepupae new    938 white prepupae 12hr    1736 white prepupae 24hr    1982 pupae 2d postWPP    1926 pupae 3d postWPP    1824 pupae 4d postWPP    2695 adult male 01day    2816 adult male 05day    3512 adult male 30day    3692 adult female 01day    1760 adult female 05day    1862 adult female 30day    2053 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  log, scaled to maximum FBgn0261550 expression level Developmental Stage   Expression Level embryo 00-02hr    2498 embryo 02-04hr    1274 embryo 04-06hr    237 embryo 06-08hr    532 embryo 08-10hr    639 embryo 10-12hr    1379 embryo 12-14hr    1288 embryo 14-16hr    1736 embryo 16-18hr    1839 embryo 18-20hr    2384 embryo 20-22hr    2293 embryo 22-24hr    2129 larva L1    1563 larva L2    1094 larva L3 12hr old    1119 larva L3 puffstage 1-2    851 larva L3 puffstage 3-6    909 larva L3 puffstage 7-9    878 white prepupae new    938 white prepupae 12hr    1736 white prepupae 24hr    1982 pupae 2d postWPP    1926 pupae 3d postWPP    1824 pupae 4d postWPP    2695 adult male 01day    2816 adult male 05day    3512 adult male 30day    3692 adult female 01day    1760 adult female 05day    1862 adult female 30day    2053 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High  log, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (2498) embryo 02-04hr  (1274) embryo 04-06hr  (237) embryo 06-08hr  (532) embryo 08-10hr  (639) embryo 10-12hr  (1379) embryo 12-14hr  (1288) embryo 14-16hr  (1736) embryo 16-18hr  (1839) embryo 18-20hr  (2384) embryo 20-22hr  (2293) embryo 22-24hr  (2129) larva L1  (1563) larva L2  (1094) larva L3 12hr old  (1119) larva L3 puffstage 1-2  (851) larva L3 puffstage 3-6  (909) larva L3 puffstage 7-9  (878) white prepupae new  (938) white prepupae 12hr  (1736) white prepupae 24hr  (1982) pupae 2d postWPP  (1926) pupae 3d postWPP  (1824) pupae 4d postWPP  (2695) adult male 01day  (2816) adult male 05day  (3512) adult male 30day  (3692) adult female 01day  (1760) adult female 05day  (1862) adult female 30day  (2053) Expression Level Scale  None   Extremely low   Very low   Low  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (2498) embryo 02-04hr    1274 embryo 04-06hr    237 embryo 06-08hr    532 embryo 08-10hr    639 embryo 10-12hr    1379 embryo 12-14hr    1288 embryo 14-16hr  1736 embryo 16-18hr  1839 embryo 18-20hr  2384 embryo 20-22hr  2293 embryo 22-24hr  2129 larva L1  1563 larva L2    1094 larva L3 12hr old    1119 larva L3 puffstage 1-2    851 larva L3 puffstage 3-6    909 larva L3 puffstage 7-9    878 white prepupae new    938 white prepupae 12hr  1736 white prepupae 24hr  1982 pupae 2d postWPP  1926 pupae 3d postWPP  1824 pupae 4d postWPP  (2695) adult male 01day  (2816) adult male 05day  (3512) adult male 30day  (3692) adult female 01day  1760 adult female 05day  1862 adult female 30day  2053 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    2498 embryo 02-04hr    1274 embryo 04-06hr    237 embryo 06-08hr    532 embryo 08-10hr    639 embryo 10-12hr    1379 embryo 12-14hr    1288 embryo 14-16hr    1736 embryo 16-18hr    1839 embryo 18-20hr    2384 embryo 20-22hr    2293 embryo 22-24hr    2129 larva L1    1563 larva L2    1094 larva L3 12hr old    1119 larva L3 puffstage 1-2    851 larva L3 puffstage 3-6    909 larva L3 puffstage 7-9    878 white prepupae new    938 white prepupae 12hr    1736 white prepupae 24hr    1982 pupae 2d postWPP    1926 pupae 3d postWPP    1824 pupae 4d postWPP    2695 adult male 01day    2816 adult male 05day    3512 adult male 30day    3692 adult female 01day    1760 adult female 05day    1862 adult female 30day    2053 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    2498 embryo 02-04hr    1274 embryo 04-06hr    237 embryo 06-08hr    532 embryo 08-10hr    639 embryo 10-12hr    1379 embryo 12-14hr    1288 embryo 14-16hr    1736 embryo 16-18hr    1839 embryo 18-20hr    2384 embryo 20-22hr    2293 embryo 22-24hr    2129 larva L1    1563 larva L2    1094 larva L3 12hr old    1119 larva L3 puffstage 1-2    851 larva L3 puffstage 3-6    909 larva L3 puffstage 7-9    878 white prepupae new    938 white prepupae 12hr    1736 white prepupae 24hr    1982 pupae 2d postWPP    1926 pupae 3d postWPP    1824 pupae 4d postWPP    2695 adult male 01day    2816 adult male 05day    3512 adult male 30day    3692 adult female 01day    1760 adult female 05day    1862 adult female 30day    2053 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     FlyAtlas Anatomical Expression Data for FBgn0261550    Styles Linear Logarithmic Heatmap Back-to-back    Scales max expr for FBgn0261550 Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Two or more Affy2 ProbeSets identify exons of this gene. This is a summary of the tissue expression peaks exhibited in at least one of these ProbeSets. Expression at high levels in the following post-embryonic organs or tissues: adult central nervous system. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, adult eye, larval central nervous system, adult crop, larval/adult midgut, larval/adult hindgut, larval/adult Malpighian tubules, adult heart, adult fat body, adult salivary gland, larval trachea, adult female reproductive system, adult male accessory gland, larval/adult carcass. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (1000 - 25000) Heatmap Tissue   Expression Level Larval Central Nervous System no informative data Larval Midgut no informative data Larval Hindgut no informative data Larval Malpighian Tubules no informative data Larval Fat Body     Larval Salivary Gland     Larval Trachea no informative data Larval Carcass no informative data Adult Head no informative data Adult Eye no informative data Adult Brain no informative data Adult Thoracic-Abdominal Ganglion no informative data Adult Crop no informative data Adult Midgut no informative data Adult Hindgut no informative data Adult Malpighian Tubules no informative data Adult Fat Body no informative data Adult Salivary Gland no informative data Adult Heart no informative data Adult VirginFemale Spermatheca no informative data Adult InseminatedFemale Spermatheca no informative data Adult Ovary no informative data Adult Testis no informative data Adult Male Accessory Gland no informative data Adult Carcass no informative data modENCODE Temporal Expression Data (Graveley et al., 2011) FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
Expression Clusters
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0038785
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele viable, with Scer\GAL4pnr-MD237 CG42668GD476 CG42668GD9085 Phenotype manifest in Allele
Classical Alleles ( 2 )
For All Classical Alleles Show
Allele of CG42668 Class Mutagen Stocks Known lesion CG42668MB04427 1 -- CG42668MI02333 1 --
Alleles Carried on Transgenic Constructs ( 6 )
For All Alleles Carried on Transgenic Constructs Show
Allele of CG42668 Class Mutagen Stocks Known lesion CG42668GD476 in vitro construct - RNAi in vitro construct - regulatory fusion 3 Yes CG42668HMS01223 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes CG42668KK111315 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes CG42668GD9085 in vitro construct - RNAi in vitro construct - regulatory fusion 0 Yes CG42668KK108193 in vitro construct - RNAi in vitro construct - regulatory fusion 0 Yes CG42668Scer\UAS.cMa in vitro construct - regulatory fusion 0 Yes
Aneuploid Aberrations
Disrupted in	Df(3R)Exel6185 (Ryder, 2004.4.26)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{KK108193} NA P{TRiP.HMS01223} NA P{UAS-CG5077.m} NA
Insertions
	Type of insertions Name Expression data miscellaneous insertions Mi{MIC}CG42668MI02333 NA P{GT1}BG01881 NA insertion of enhancer trap binary system Mi{ET1}CG42668MB04427 No
Gene Ontology: Function, Process & Cellular Component ( 1 unique term )
Terms Based on Experimental Evidence ( 0 terms )
Terms Based on Predictions or Assertions ( 1 term )
Molecular Function
CV term Evidence References
oxysterol binding inferred from sequence or structural similarity with EMBL:Y12693 (FlyBase, 1992-)
Biological Process ( 0 terms)
Cellular Component ( 0 terms)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Protein-protein
Interacting group Assay References
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions CG42668 allele Gene References
External Data
Linkouts	DroID - A comprehensive database of gene and protein interactions. • FBgn0261550 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 42412
Orthologs
Genome-wide drosophilid orthologs	Dana\GF23022 Dana\GF23024 Dere\GG23834 Dere\GG23845 Dgri\GH22536 Dgri\GH22541 Dmoj\GI22227 Dper\GL23459 Dper\GL23461 Dpse\GA30150 Dsec\GM23105 Dsec\GM23106 Dsim\GD19346 Dsim\GD19347 Dvir\GJ24348 Dvir\GJ24349 Dwil\GK22444 Dyak\GE25660 Dyak\GE25661
Curated drosophilid orthologs	Dpse\GA30150
Linkouts	OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • PB10044 NV15630 LH23271 ISCW002574 FBgn0229037 FBgn0224421 FBgn0211429 FBgn0177974 JGI_V11_225360 FBgn0078643 FBgn0161051 FBgn0144955 FBgn0129999 FBgn0115984 FBgn0100016 CPIJ018803 BGIBMGA001811 GB18854 AGAP003484 AAEL010483 PHUM459060 GLEAN_16041
Stocks & Reagents
Stocks Listed in FlyBase ( 7 )
Bloomington	24702 w1118; Mi{ET1}CG42668MB04427 34315 y1 w*; Mi{MIC}CG42668MI02333 34743 y1 sc* v1; P{TRiP.HMS01223}attP2
VDRC	v104813 P{KK111315}VIE-260B v6765 w1118; P{GD476}v6765 v6766 w1118; P{GD476}v6766 v24491 w1118; P{GD476}v24491/TM3
Genomic Clones ( 1 )
	BACR38H07 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 56 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	AT13393 AT23163 GH25973 RE22568
Other clones	FI12001
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	AT10650 AT25438 AT26587 AT29888 GH03414 GM20163 GM32002 LP06678 LP15903 RH20964 RH25706 RH26161 RH32948 RH37882 RH53169 RH72985 SD02686
Other clones	341 2178 8840 10820 63071 64182 70636 75262 104420 105835 118494 146427 147433 159063 177731 214471.62 bs01f02 CK01.14A.F1 CK01.79D.D12 EK051023 EK061848 EK074205 EK105345 EK108122 EK111013 EK183408 EK189636 EK190144 EK207415 EK249916 EP04941 EP08835 EP10913 ESG0115b.B21_G01
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0261550 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 42411 42412
Antibody Information
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of
Source for database merge of	Source for merge of: CG15684 (FlyBase Genome Annotators, 2010)
Additional comments	Annotations CG15684 and CG5077 merged as CG42668 in release 5.25 of the genome annotation. (FlyBase Genome Annotators, 2010)
Other Comments
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_142621 NM_169892 NM_169893 NM_169894 NM_001144614 NM_001202322 NM_001202323 RefSeq (Proteins) • NP_650878 NP_732499 NP_732500 NP_732501 NP_001138086 NP_001189251 NP_001189252 DDBJ / EMBL / GenBank • AAG22160 AAG22160.1 AAK93038 AAN13825 AAN13825.1 AAN13826 AAN13826.1 AAN13826.2 AAN13827 AAN13827.1 ACL83542 ADV37340 ADV37341 ADV37342 ADV37343 AI405834 AI944454 AW941003 AY051614 BF488079 Entrez Gene - A searchable database of RefSeq genes. • 42411 42412 UniProtKB/TrEMBL • B7Z0M9 Q7KSB3 Q8IN55 Q8IN56 Q9I7I8 Q9VDN5
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Oxysterol-binding protein (IPR000648) Pleckstrin homology domain (IPR001849) Pleckstrin homology-type (IPR011993) Oxysterol-binding protein, conserved site (IPR018494)
Linkouts
	DroID - A comprehensive database of gene and protein interactions. • FBgn0261550 DRSC - Results from RNAi screens. • FBgn0261550 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0038785 FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0261550 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 42411 42412 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 42412 modMine - Data generated by the modENCODE project. • FBgn0261550 OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • PB10044 NV15630 LH23271 ISCW002574 FBgn0229037 FBgn0224421 FBgn0211429 FBgn0177974 JGI_V11_225360 FBgn0078643 FBgn0161051 FBgn0144955 FBgn0129999 FBgn0115984 FBgn0100016 CPIJ018803 BGIBMGA001811 GB18854 AGAP003484 AAEL010483 PHUM459060 GLEAN_16041
Synonyms & Secondary IDs ( 3 )
Reported As
Symbol Synonym	CG5077 (Okumura et al., 2007, Ma et al., 2010, Keleman et al., 2009.8.5, Cammarato et al., 2011) CG15684 (Keleman et al., 2009.8.5) CG42668 (FlyBase Genome Annotators, 2010, Ma et al., 2010, Ni et al., 2010.12.1, Wasbrough et al., 2010)
Name Synonym
Secondary FlyBase IDs
	FBgn0038785 FBgn0038786
References ( 18 )
Research paper	Ma et al., 2010, Development 137(22): 3775--3784 OSBP- and FAN-mediated sterol requirement for spermatogenesis in Drosophila. [FBrf0212194] Okumura et al., 2007, Gene Expression Patterns 7(1-2): 178--186 GATAe-dependent and -independent expressions of genes in the differentiated endodermal midgut of Drosophila. [FBrf0194340]
Supplementary material	Cammarato et al., 2011, PLoS ONE 6(4): Table S1. Proteins & Peptides. [FBrf0214682] Wasbrough et al., 2010, J. Proteomics 73(11): Supplemental Table 1. Mass spectrometry data. [FBrf0213252] Mummery-Widmer et al., 2009, Nature 458(7241): Supplementary Table 2 - Genome-wide bristle screen results. [FBrf0214518]
Personal communication to FlyBase	Bellen, 2011.1.31, set919.xml set919.xml [FBrf0212923] Ni et al., 2010.12.1, A genome-scale shRNA resource for transgenic RNAi in Drosophila. A genome-scale shRNA resource for transgenic RNAi in Drosophila. [FBrf0212437] Keleman et al., 2009.8.5, RNAi-phiC31 construct and insertion data submitted by the Vienna Drosophila RNAi Center RNAi-phiC31 construct and insertion data submitted by the Vienna Drosophila RNAi Center [FBrf0208510] BDGP TI submission, 2007.10.30, batch763.xml batch763.xml [FBrf0200261] Dickson et al., 2007.7.18, RNAi construct and insertion data submitted by the Vienna Drosophila RNAi Center RNAi construct and insertion data submitted by the Vienna Drosophila RNAi Center [FBrf0200327] Ryder, 2004.4.26, Exelixis CG deletion data. Exelixis CG deletion data. [FBrf0184335] Oliver, 2001.8.16, File from B. Oliver containing information on ESTs expressed in the Drosophila testis, described in Andrews et al., 2000, Genome Res. 10(12): 2030-2043 (FBrf0132348). File from B. Oliver containing information on ESTs expressed in the Drosophila testis, described in Andrews et al., 2000, Genome Res. 10(12): 2030-2043 (FBrf0132348). [FBrf0137492]
FlyBase analysis	FlyBase Genome Annotators, 2010, Changes affecting gene model number or type in release 5.25 of the annotated D.melanogaster genome. Changes affecting gene model number or type in release 5.25 of the annotated D.melanogaster genome. [FBrf0209656] FlyBase, 1992-, FlyBase curation FlyBase curation. [FBrf0105495]
Computer file	Gene Disruption Project members, 2001-, [title not yet available] [title not yet available] [FBrf0132177] BDGP Project Members, 2000-, Berkeley Drosophila Genome Project. Berkeley Drosophila Genome Project. [FBrf0125078]
Automatic genome annotation	FamiliarityBreedsContempt, 1999.11, [Annotations performed at the Celera Jamboreee.] [Annotations performed at the Celera Jamboreee.] [FBrf0126705]
Curated genome annotation	Milshina, 1999.11, [Annotations performed at the Celera Jamboreee.] [Annotations performed at the Celera Jamboreee.] [FBrf0126686]