A Database of Drosophila Genes & Genomes

FB2013_03, released May 7th, 2013
 

Gene Dmel\Thor

General Information
SymbolDmel\ThorSpeciesD. melanogaster
NameThorAnnotation symbolCG8846
Feature typeprotein_coding_geneFlyBase IDFBgn0261560
Gene Model StatusCurrent Stock availability 15 publicly available
Also Known As4E-BP, d4E-BP, 4EBP, d4EBP, Phas1, 4E-BP1, l(2)k07736
Genomic Location
Chromosome (arm)2LRecombination map
Cytogenetic map23F3-23F6Sequence location2L:3,478,434..3,479,612 [+]

Genomic Maps

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Automatically generated summary

See sections below for more information
The gene Thor is referred to in FlyBase by the symbol Dmel\Thor (CG8846, FBgn0261560). It is a protein_coding_gene from Drosophila melanogaster. There is experimental evidence that it has the molecular function: eukaryotic initiation factor 4E binding. There is experimental evidence that it is involved in the biological process: response to starvation; immune response; determination of adult lifespan; response to oxidative stress; regulation of cell growth; triglyceride metabolic process; negative regulation of cell size; response to stress; antibacterial humoral response; regulation of mitochondrial translation. 29 alleles are reported. The phenotypes of these alleles are annotated with: wing disc; 1st posterior cell; retina; embryonic/larval fat body; wing; type I bouton; adult brain; abdominal adult fat mass; muscle cell. It has one annotated transcript and one annotated polypeptide. Protein features are: Eukaryotic translation initiation factor 4E binding. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of very high expression to a trough of moderate expression. Peak expression observed within 18-24 hour embryonic stages, at stages throughout the larval period, during early pupal stages, in stages of adults of both sexes. Summary of FlyAtlas Anatomical Expression Data: Nearly all larval and adult organs/tissues expressed at high levels. Expression at high levels in the following post-embryonic organs or tissues: adult head, adult eye, adult crop, larval/adult midgut, larval/adult hindgut, larval/adult Malpighian tubules, adult heart, larval/adult fat body, larval/adult salivary gland, larval trachea, adult spermathecae, adult male accessory gland, larval/adult carcass. Expression at moderate levels in the following post-embryonic organs or tissues: adult thoracico-abdominal ganglion, adult ovary, adult testis. Comments on Affy2 ProbeSet: ProbeSet 1635900_at completely aligns to an exonic region of the only FlyBase-annotated transcript isoform of Thor. Gene sequence location is 2L:3478434..3479612.

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Description
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FB2013_03
FB2013_02
All updates Click here to see a list of all updates to this record from FB2010_08 and on.
hide Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map
Evidence for location
23F3-23F6  
Limits computationally determined from genome sequence between P{EP}ThorEP818&P{lacW}Thork07736 and P{PZ}oddrF111&P{PZ}for06860; Left limit from in situ hybridisation (FBrf0067338) Right limit from in situ hybridisation (FBrf0067338)  
Experimentally Determined Cytological Location
Cytogenetic map
Notes
References
23F5-23F6  
(determined by in situ hybridisation)  
(Spradling et al., 1999)
23F-24A  
(determined by in situ hybridisation)  
(Rodriguez et al., 1996)
23F5-23F6  
 
(BDGP Project Members, 1994-1999)
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
hide Gene Model & Products
Please see the GBrowse view of Dmel\Thor for information on other features GBrowse View Help
To submit a correction to a gene model please use the Contact FlyBase form
detailed view FBtr0333249 FBtr0077524 FBtr0077568 FBpp0077213 FBpp0077257 FBti0056784 FBti0054493 FBti0107684 FBti0058842 FBti0077961 FBti0105478 FBti0107740 FBti0026213 FBti0026161 FBti0110253 FBti0107420 FBti0010969 FBti0111771 FBti0007751 FBti0070518 FBti0104132 FBti0054424 FBti0040002 FBti0033712 FBti0006930 FBti0106358 FBti0069572 FBti0029427 FBti0103419 FBti0100795 FBti0010987 FBti0036842 FBti0100907 FBti0111266 FBti0110052 FBti0033644 FBti0010835 FBti0105882 FBti0035802 FBti0010978 FBti0034889 FBti0103987 FBti0009315 FBti0115483 FBti0016928 FBti0011060 FBti0006439 FBti0007702 FBti0005305 FBti0006675_1 FBti0111061 FBti0011230 FBti0112515 FBti0006675_2 FBti0109702 FBti0034039 FBti0105404 FBti0107629 FBti0143993 FBti0010777 FBti0024766 FBti0049865
Comments on Gene Model
Gene model reviewed during 5.46
Low-frequency RNA-Seq exon junction(s) not annotated.
hide Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Associated CDS (aa)
Thor-RA
FBtr0077524
 NM_057947
  755
  117
Additional Transcript Data & Comments
Reported size (kB)
0.85 (northern blot)
(Bernal and Kimbrell, 2000)
Comments
External Data
Crossreferences
hide Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
RefSeq ID
GenBank protein
Thor-PA  
FBpp0077213  
12.9  
117  
10.19  
  NP_477295
  AAF51100
Additional Polypeptide Data & Comments
Reported size (kDa)
117 (aa)
(Bernal and Kimbrell, 2000)
Comments
External Data
Linkouts
Crossreferences
InterPro domains - A database of protein families, domains, and functional sites
•
Eukaryotic translation initiation factor 4E binding (IPR008606)
hide Sequences Consistent with the Gene Model
DDBJ /
EMBL /
GenBank
DNA sequence
Protein sequence
Name
AA699260
 
AE014134
AAF51100
 
AC008323
 
AF132557
AAD27856
 
AF244353
AAF82476
 
AI108456
 
AI109714
 
AI114128
 
AI134284
 
AI135041
 
AI135483
 
AI237972
 
AI258497
 
AI260206
 
AI260954
 
AI293568
 
AI297034
 
AI297649
 
AI387089
 
AI388839
 
AI405614
 
AI405877
 
AI405902
 
AI517778
 
AQ025649
 
AQ025845
 
AQ074032
 
AW941465
 
AX260196
 
BE978766
 
BG635890
 
BG637178
 
BG640084
 
BI168989
 
BI357224
 
BI358006
 
BI633289
 
BI637797
 
BI641139
 
BI641270
 
CA803296
 
CA803531
 
CA803669
 
CA803696
 
CA804034
 
CA804305
 
CA804416
 
CA804635
 
CA804772
 
CA804805
 
CA805027
 
CA805197
 
CA805555
 
CA805963
 
CA806057
 
CA806114
 
CA806125
 
CA806258
 
CA806325
 
CA807088
 
CA807497
 
CA807525
 
CA807615
 
CA807784
 
CO181821
 
CO182480
 
CO184297
 
CO192484
 
CO194037
 
CO195288
 
CO276311
 
CO278145
 
CO284487
 
CO308034
 
CO314406
 
CO323788
 
EC063263
 
EC071527
 
EC088049
 
EC214986
 
EC221472
 
EC222149
 
EC224090
 
EL883358
 
EV576286
 
FF579042
 
FF579117
 
FF579235
 
FF579247
 
 
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL
hide Mapped Features
Mapped Features have been reorganized, please see this article for details.
Additional mapped features and mutations can be found on GBrowse or related reports.
Type
Symbol & Location
Additional Notes
References
protein binding site
FBsf0000159867
2L:3,478,149..3,478,161
comment=bound_moiety is NF-kB
evidence=predicted
(Bernal and Kimbrell, 2000)
protein binding site
FBsf0000159866
2L:3,478,137..3,478,146
comment=bound_moiety is NF-kB
evidence=predicted
(Bernal and Kimbrell, 2000)
hide External Data
Linkouts
Crossreferences
hide Expression Data
hideTranscript Expression
in situ
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage 4 -- 6  
anlage in statu nascendi  
(Fisher et al., 2012)
central brain anlage in statu nascendi  
(Fisher et al., 2012)
posterior ectoderm anlage  
(Fisher et al., 2012)
Comment:anlage in statu nascendi
ventral ectoderm anlage  
(Fisher et al., 2012)
Comment:anlage in statu nascendi
antennal anlage in statu nascendi  
(Fisher et al., 2012)
Comment:reported as procephalic ectoderm anlage in statu nascendi
dorsal head epidermis anlage in statu nascendi  
(Fisher et al., 2012)
Comment:reported as procephalic ectoderm anlage in statu nascendi
visual anlage in statu nascendi  
(Fisher et al., 2012)
Comment:reported as procephalic ectoderm anlage in statu nascendi
embryonic stage 7 -- 8  
antennal anlage  
(Fisher et al., 2012)
Comment:reported as procephalic ectoderm anlage
central brain anlage  
(Fisher et al., 2012)
Comment:reported as procephalic ectoderm anlage
dorsal head epidermis anlage  
(Fisher et al., 2012)
Comment:reported as procephalic ectoderm anlage
visual anlage  
(Fisher et al., 2012)
Comment:reported as procephalic ectoderm anlage
anterior endoderm anlage  
(Fisher et al., 2012)
posterior endoderm  
(Fisher et al., 2012)
embryonic stage 9 -- 10  
amnioserosa  
(Fisher et al., 2012)
antennal primordium  
(Fisher et al., 2012)
Comment:reported as procephalic ectoderm primordium
central brain primordium  
(Fisher et al., 2012)
Comment:reported as procephalic ectoderm primordium
visual primordium  
(Fisher et al., 2012)
Comment:reported as procephalic ectoderm primordium
dorsal head epidermis primordium  
(Fisher et al., 2012)
Comment:reported as procephalic ectoderm primordium
lateral head epidermis primordium  
(Fisher et al., 2012)
Comment:reported as procephalic ectoderm primordium
ventral head epidermis primordium  
(Fisher et al., 2012)
Comment:reported as procephalic ectoderm primordium
anterior endoderm  
(Fisher et al., 2012)
posterior endoderm  
(Fisher et al., 2012)
ventral nerve cord primordium  
(Fisher et al., 2012)
embryonic stage 11 -- 12  
amnioserosa  
(Fisher et al., 2012)
central brain primordium  
(Fisher et al., 2012)
ventral nerve cord primordium  
(Fisher et al., 2012)
embryonic stage 13 -- 16  
apoptotic amnioserosa  
(Fisher et al., 2012)
embryonic brain  
(Fisher et al., 2012)
embryonic Malpighian tubule  
(Fisher et al., 2012)
embryonic/larval nervous system  
(Fisher et al., 2012)
embryonic/larval salivary gland  
(Fisher et al., 2012)
lateral cord neuron  
(Fisher et al., 2012)
ventral midline  
(Fisher et al., 2012)
ventral nerve cord  
(Fisher et al., 2012)
northern blot
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage  
presumptive embryonic/larval central nervous system  
(Bernal and Kimbrell, 2000)
embryonic stage -- adult stage  
 
(Bernal and Kimbrell, 2000)
third instar larval stage  
testis  
(Bernal and Kimbrell, 2000)
adult stage & oogenesis  
nurse cell  
(Bernal and Kimbrell, 2000)
ovary  
(Bernal and Kimbrell, 2000)
Additional Descriptive Data
Thor transcripts are detected at all stages on northern blots and are strongly induced upon infection. They are observed by in situ hybridization in the embryonic central nervous system and in the reproductive systems of males and females. They are observed third instar male testis and in adult female ovaries.
(Bernal and Kimbrell, 2000)
Marker for
Subcellular Localization
CV Term
hide Polypeptide Expression
Additional Descriptive Data
Marker for
Subcellular Localization (GO Cellular Component)
CV term
Evidence
References
hide Expression Deduced from Reporters
Reporter: P{lacW}Thork13517
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage  
presumptive embryonic/larval central nervous system  
(Rodriguez et al., 1996)
larval stage  
embryonic/larval midgut  
(Rodriguez et al., 1996)
ring gland  
(Rodriguez et al., 1996)
mouth hooks  
(Rodriguez et al., 1996)
gastric caecum  
(Rodriguez et al., 1996)
embryonic/larval esophagus  
(Rodriguez et al., 1996)
embryonic/larval salivary gland  
(Rodriguez et al., 1996)
embryonic/larval proventriculus | restricted  
(Rodriguez et al., 1996)
larval stage & adult stage  
Malpighian tubule  
(Rodriguez et al., 1996)
fat body  
(Rodriguez et al., 1996)
adult stage  
eye  
(Rodriguez et al., 1996)
adult esophagus  
(Rodriguez et al., 1996)
adult midgut  
(Rodriguez et al., 1996)
adult salivary gland  
(Rodriguez et al., 1996)
hide High-Throughput Expression Data
Associated Tools
Reference
See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes.
hide FlyAtlas Anatomy Microarray

FlyAtlas Anatomical Expression Data

(FlyAtlas-RNA.adult)

(FlyAtlas-RNA.larva)


   Styles
   Scales

Summary of FlyAtlas Anatomical Expression Data: Nearly all larval and adult organs/tissues expressed at high levels. Expression at high levels in the following post-embryonic organs or tissues: adult head, adult eye, adult crop, larval/adult midgut, larval/adult hindgut, larval/adult Malpighian tubules, adult heart, larval/adult fat body, larval/adult salivary gland, larval trachea, adult spermathecae, adult male accessory gland, larval/adult carcass. Expression at moderate levels in the following post-embryonic organs or tissues: adult thoracico-abdominal ganglion, adult ovary, adult testis.
[download data (TSV)]

Guide to FlyAtlas expression level colors
 
 No expression (0 - 9.999)
 
 Low expression (10 - 99.999)
 
 Moderate expression (100 - 499.999)
 
 High level expression (500 - 999.999)
 
 Very high expression (>999.999)

Linear, scaled to maximum expression level
Tissue   Expression Level
Larval Central Nervous System
 
 83.5
Larval Midgut
 
 2638.3
Larval Hindgut
 
 1673.2
Larval Malpighian Tubules
 
 1564.3
Larval Fat Body
 
 8156
Larval Salivary Gland
 
 4484.2
Larval Trachea
 
 1765.65
Larval Carcass
 
 2530
Adult Head
 
 1530.5
Adult Eye
 
 1916.275
Adult Brain
 
 86.2
Adult Thoracic-Abdominal Ganglion
 
 111.8
Adult Crop
 
 3061.5
Adult Midgut
 
 3319.5
Adult Hindgut
 
 2347.8
Adult Malpighian Tubules
 
 1858.2
Adult Fat Body
 
 3304.9
Adult Salivary Gland
 
 10501
Adult Heart
 
 3412.625
Adult VirginFemale Spermatheca
 
 2634.2
Adult InseminatedFemale Spermatheca
 
 2463.3
Adult Ovary
 
 358.9
Adult Testis
 
 112.1
Adult Male Accessory Gland
 
 1596.5
Adult Carcass
 
 3274.4
Expression Level Scale
 None 
 Low 
 Moderate 
 High 
 Very high 
Linear, scaled to Moderate expression
Tissue   Expression Level
Larval Central Nervous System
 
 83.5
Larval Midgut
 (2638.3)
Larval Hindgut
 (1673.2)
Larval Malpighian Tubules
 (1564.3)
Larval Fat Body
 (8156)
Larval Salivary Gland
 (4484.2)
Larval Trachea
 (1765.65)
Larval Carcass
 (2530)
Adult Head
 (1530.5)
Adult Eye
 (1916.275)
Adult Brain
 
 86.2
Adult Thoracic-Abdominal Ganglion
 
 111.8
Adult Crop
 (3061.5)
Adult Midgut
 (3319.5)
Adult Hindgut
 (2347.8)
Adult Malpighian Tubules
 (1858.2)
Adult Fat Body
 (3304.9)
Adult Salivary Gland
 (10501)
Adult Heart
 (3412.625)
Adult VirginFemale Spermatheca
 (2634.2)
Adult InseminatedFemale Spermatheca
 (2463.3)
Adult Ovary
 
 358.9
Adult Testis
 
 112.1
Adult Male Accessory Gland
 (1596.5)
Adult Carcass
 (3274.4)
Expression Level Scale
 None 
 Low 
 Moderate 
 High 
Linear, scaled to High level expression
Tissue   Expression Level
Larval Central Nervous System
 
 83.5
Larval Midgut
 (2638.3)
Larval Hindgut
 (1673.2)
Larval Malpighian Tubules
 (1564.3)
Larval Fat Body
 (8156)
Larval Salivary Gland
 (4484.2)
Larval Trachea
 (1765.65)
Larval Carcass
 (2530)
Adult Head
 (1530.5)
Adult Eye
 (1916.275)
Adult Brain
 
 86.2
Adult Thoracic-Abdominal Ganglion
 
 111.8
Adult Crop
 (3061.5)
Adult Midgut
 (3319.5)
Adult Hindgut
 (2347.8)
Adult Malpighian Tubules
 (1858.2)
Adult Fat Body
 (3304.9)
Adult Salivary Gland
 (10501)
Adult Heart
 (3412.625)
Adult VirginFemale Spermatheca
 (2634.2)
Adult InseminatedFemale Spermatheca
 (2463.3)
Adult Ovary
 
 358.9
Adult Testis
 
 112.1
Adult Male Accessory Gland
 (1596.5)
Adult Carcass
 (3274.4)
Expression Level Scale
 None 
 Low 
 Moderate 
 High 
 Very high 
Linear, scaled to Very high expression
Tissue   Expression Level
Larval Central Nervous System
 
 83.5
Larval Midgut
 
 2638.3
Larval Hindgut
 
 1673.2
Larval Malpighian Tubules
 
 1564.3
Larval Fat Body
 
 8156
Larval Salivary Gland
 
 4484.2
Larval Trachea
 
 1765.65
Larval Carcass
 
 2530
Adult Head
 
 1530.5
Adult Eye
 
 1916.275
Adult Brain
 
 86.2
Adult Thoracic-Abdominal Ganglion
 
 111.8
Adult Crop
 
 3061.5
Adult Midgut
 
 3319.5
Adult Hindgut
 
 2347.8
Adult Malpighian Tubules
 
 1858.2
Adult Fat Body
 
 3304.9
Adult Salivary Gland
 
 10501
Adult Heart
 
 3412.625
Adult VirginFemale Spermatheca
 
 2634.2
Adult InseminatedFemale Spermatheca
 
 2463.3
Adult Ovary
 
 358.9
Adult Testis
 
 112.1
Adult Male Accessory Gland
 
 1596.5
Adult Carcass
 
 3274.4
Expression Level Scale
 Very high 
log, scaled to maximum expression level
Tissue   Expression Level
Larval Central Nervous System
 
 83.5
Larval Midgut
 
 2638.3
Larval Hindgut
 
 1673.2
Larval Malpighian Tubules
 
 1564.3
Larval Fat Body
 
 8156
Larval Salivary Gland
 
 4484.2
Larval Trachea
 
 1765.65
Larval Carcass
 
 2530
Adult Head
 
 1530.5
Adult Eye
 
 1916.275
Adult Brain
 
 86.2
Adult Thoracic-Abdominal Ganglion
 
 111.8
Adult Crop
 
 3061.5
Adult Midgut
 
 3319.5
Adult Hindgut
 
 2347.8
Adult Malpighian Tubules
 
 1858.2
Adult Fat Body
 
 3304.9
Adult Salivary Gland
 
 10501
Adult Heart
 
 3412.625
Adult VirginFemale Spermatheca
 
 2634.2
Adult InseminatedFemale Spermatheca
 
 2463.3
Adult Ovary
 
 358.9
Adult Testis
 
 112.1
Adult Male Accessory Gland
 
 1596.5
Adult Carcass
 
 3274.4
Expression Level Scale
 None 
 Low 
 Moderate 
 High 
 Very high 
log, scaled to Moderate expression
Tissue   Expression Level
Larval Central Nervous System
 
 83.5
Larval Midgut
 (2638.3)
Larval Hindgut
 (1673.2)
Larval Malpighian Tubules
 (1564.3)
Larval Fat Body
 (8156)
Larval Salivary Gland
 (4484.2)
Larval Trachea
 (1765.65)
Larval Carcass
 (2530)
Adult Head
 (1530.5)
Adult Eye
 (1916.275)
Adult Brain
 
 86.2
Adult Thoracic-Abdominal Ganglion
 
 111.8
Adult Crop
 (3061.5)
Adult Midgut
 (3319.5)
Adult Hindgut
 (2347.8)
Adult Malpighian Tubules
 (1858.2)
Adult Fat Body
 (3304.9)
Adult Salivary Gland
 (10501)
Adult Heart
 (3412.625)
Adult VirginFemale Spermatheca
 (2634.2)
Adult InseminatedFemale Spermatheca
 (2463.3)
Adult Ovary
 
 358.9
Adult Testis
 
 112.1
Adult Male Accessory Gland
 (1596.5)
Adult Carcass
 (3274.4)
Expression Level Scale
 None 
 Low 
 Moderate 
 High 
log, scaled to High level expression
Tissue   Expression Level
Larval Central Nervous System
 
 83.5
Larval Midgut
 (2638.3)
Larval Hindgut
 1673.2
Larval Malpighian Tubules
 1564.3
Larval Fat Body
 (8156)
Larval Salivary Gland
 (4484.2)
Larval Trachea
 (1765.65)
Larval Carcass
 (2530)
Adult Head
 1530.5
Adult Eye
 (1916.275)
Adult Brain
 
 86.2
Adult Thoracic-Abdominal Ganglion
 
 111.8
Adult Crop
 (3061.5)
Adult Midgut
 (3319.5)
Adult Hindgut
 (2347.8)
Adult Malpighian Tubules
 (1858.2)
Adult Fat Body
 (3304.9)
Adult Salivary Gland
 (10501)
Adult Heart
 (3412.625)
Adult VirginFemale Spermatheca
 (2634.2)
Adult InseminatedFemale Spermatheca
 (2463.3)
Adult Ovary
 
 358.9
Adult Testis
 
 112.1
Adult Male Accessory Gland
 1596.5
Adult Carcass
 (3274.4)
Expression Level Scale
 None 
 Low 
 Moderate 
 High 
 Very high 
log, scaled to Very high expression
Tissue   Expression Level
Larval Central Nervous System
 
 83.5
Larval Midgut
 
 2638.3
Larval Hindgut
 
 1673.2
Larval Malpighian Tubules
 
 1564.3
Larval Fat Body
 
 8156
Larval Salivary Gland
 
 4484.2
Larval Trachea
 
 1765.65
Larval Carcass
 
 2530
Adult Head
 
 1530.5
Adult Eye
 
 1916.275
Adult Brain
 
 86.2
Adult Thoracic-Abdominal Ganglion
 
 111.8
Adult Crop
 
 3061.5
Adult Midgut
 
 3319.5
Adult Hindgut
 
 2347.8
Adult Malpighian Tubules
 
 1858.2
Adult Fat Body
 
 3304.9
Adult Salivary Gland
 
 10501
Adult Heart
 
 3412.625
Adult VirginFemale Spermatheca
 
 2634.2
Adult InseminatedFemale Spermatheca
 
 2463.3
Adult Ovary
 
 358.9
Adult Testis
 
 112.1
Adult Male Accessory Gland
 
 1596.5
Adult Carcass
 
 3274.4
Expression Level Scale
 None 
 Low 
 Moderate 
 High 
 Very high 
Heatmap
Tissue   Expression Level
Larval Central Nervous System
 
 
Larval Midgut
 
 
Larval Hindgut
 
 
Larval Malpighian Tubules
 
 
Larval Fat Body
 
 
Larval Salivary Gland
 
 
Larval Trachea
 
 
Larval Carcass
 
 
Adult Head
 
 
Adult Eye
 
 
Adult Brain
 
 
Adult Thoracic-Abdominal Ganglion
 
 
Adult Crop
 
 
Adult Midgut
 
 
Adult Hindgut
 
 
Adult Malpighian Tubules
 
 
Adult Fat Body
 
 
Adult Salivary Gland
 
 
Adult Heart
 
 
Adult VirginFemale Spermatheca
 
 
Adult InseminatedFemale Spermatheca
 
 
Adult Ovary
 
 
Adult Testis
 
 
Adult Male Accessory Gland
 
 
Adult Carcass
 
 

FlyAtlas Organ/Tissue Expression, larval vs. adult
Larval Expression Level Tissue Adult Expression Level
 
NA 		 Head
 
 1530.5
 
NA 		 Eye
 
 1916.275
 
NA 		 Brain
 
 86.2
 
83.5 		 Central Nervous System
 
 NA
 
NA 		 Thoracic-Abdominal Ganglion
 
 111.8
 
NA 		 Crop
 
 3061.5
 
2638.3 		 Midgut
 
 3319.5
 
1673.2 		 Hindgut
 
 2347.8
 
1564.3 		 Malpighian Tubules
 
 1858.2
 
8156 		 Fat Body
 
 3304.9
 
4484.2 		 Salivary Gland
 
 10501
 
NA 		 Heart
 
 3412.625
 
1765.65 		 Trachea
 
 NA
 
NA 		 VirginFemale Spermatheca
 
 2634.2
 
NA 		 InseminatedFemale Spermatheca
 
 2463.3
 
NA 		 Ovary
 
 358.9
 
NA 		 Testis
 
 112.1
 
NA 		 Male Accessory Gland
 
 1596.5
 
2530 		 Carcass
 
 3274.4

FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
hide modENCODE Anatomy RNA-Seq

modENCODE Tissue Expression Data

(modENCODE_mRNA-Seq_tissues)


   Styles
   Scales


[download data (TSV)]

Guide to modENCODE expression level colors
 
 No/Extremely low expression (0 - 0)
 
 Very low expression (1 - 3)
 
 Low expression (4 - 10)
 
 Moderate expression (11 - 25)
 
 Moderately high expression (26 - 50)
 
 High expression (51 - 100)
 
 Very high expression (101 - 1000)
 
 Extremely high expression (>1000)

Linear, scaled to maximum expression level
Tissue   Expression Level
imaginal disc, larvae L3 wandering
 
 60
central nervous system, larvae L3
 
 57
central nervous system, pupae P8
 
 2
head, virgin 1-day female
 
 48
head, virgin 4-day female
 
 106
head, virgin 20-day female
 
 238
head, mated 1-day female
 
 88
head, mated 4-day female
 
 51
head, mated 20-day female
 
 183
head, mated 1-day male
 
 42
head, mated 4-day male
 
 22
head, mated 20-day male
 
 56
salivary gland, larvae L3 wandering
 
 388
salivary gland, white prepupae
 
 69
digestive system, larvae L3 wandering
 
 108
digestive system, 1-day adult
 
 77
digestive system, 4-day adult
 
 38
digestive system, 20-day adult
 
 63
fat body, larvae L3 wandering
 
 228
fat body, white prepupae
 
 243
fat body, pupae P8
 
 13
carcass, larvae L3 wandering
 
 66
carcass, 1-day adult
 
 167
carcass, 4-day adult
 
 114
carcass, 20-day adult
 
 220
ovary, virgin 4-day female
 
 14
ovary, mated 4-day female
 
 13
testis, mated 4-day male
 
 13
accessory gland, mated 4-day male
 
 31
Expression Level Scale
 Very low 
 Low 
 Moderate 
 Moderately high 
 High 
 Very high 
Linear, scaled to Moderate expression
Tissue   Expression Level
imaginal disc, larvae L3 wandering
 (60)
central nervous system, larvae L3
 (57)
central nervous system, pupae P8
 
 2
head, virgin 1-day female
 (48)
head, virgin 4-day female
 (106)
head, virgin 20-day female
 (238)
head, mated 1-day female
 (88)
head, mated 4-day female
 (51)
head, mated 20-day female
 (183)
head, mated 1-day male
 (42)
head, mated 4-day male
 
 22
head, mated 20-day male
 (56)
salivary gland, larvae L3 wandering
 (388)
salivary gland, white prepupae
 (69)
digestive system, larvae L3 wandering
 (108)
digestive system, 1-day adult
 (77)
digestive system, 4-day adult
 (38)
digestive system, 20-day adult
 (63)
fat body, larvae L3 wandering
 (228)
fat body, white prepupae
 (243)
fat body, pupae P8
 
 13
carcass, larvae L3 wandering
 (66)
carcass, 1-day adult
 (167)
carcass, 4-day adult
 (114)
carcass, 20-day adult
 (220)
ovary, virgin 4-day female
 
 14
ovary, mated 4-day female
 
 13
testis, mated 4-day male
 
 13
accessory gland, mated 4-day male
 (31)
Expression Level Scale
 Very low 
 Low 
 Moderate 
 Moderately high 
Linear, scaled to High expression
Tissue   Expression Level
imaginal disc, larvae L3 wandering
 
 60
central nervous system, larvae L3
 
 57
central nervous system, pupae P8
 
 2
head, virgin 1-day female
 
 48
head, virgin 4-day female
 106
head, virgin 20-day female
 (238)
head, mated 1-day female
 
 88
head, mated 4-day female
 
 51
head, mated 20-day female
 (183)
head, mated 1-day male
 
 42
head, mated 4-day male
 
 22
head, mated 20-day male
 
 56
salivary gland, larvae L3 wandering
 (388)
salivary gland, white prepupae
 
 69
digestive system, larvae L3 wandering
 (108)
digestive system, 1-day adult
 
 77
digestive system, 4-day adult
 
 38
digestive system, 20-day adult
 
 63
fat body, larvae L3 wandering
 (228)
fat body, white prepupae
 (243)
fat body, pupae P8
 
 13
carcass, larvae L3 wandering
 
 66
carcass, 1-day adult
 (167)
carcass, 4-day adult
 (114)
carcass, 20-day adult
 (220)
ovary, virgin 4-day female
 
 14
ovary, mated 4-day female
 
 13
testis, mated 4-day male
 
 13
accessory gland, mated 4-day male
 
 31
Expression Level Scale
 Very low 
 Low 
 Moderate 
 Moderately high 
 High 
 Very high 
Linear, scaled to Extremely high expression
Tissue   Expression Level
imaginal disc, larvae L3 wandering
 
 60
central nervous system, larvae L3
 
 57
central nervous system, pupae P8
 
 2
head, virgin 1-day female
 
 48
head, virgin 4-day female
 
 106
head, virgin 20-day female
 
 238
head, mated 1-day female
 
 88
head, mated 4-day female
 
 51
head, mated 20-day female
 
 183
head, mated 1-day male
 
 42
head, mated 4-day male
 
 22
head, mated 20-day male
 
 56
salivary gland, larvae L3 wandering
 
 388
salivary gland, white prepupae
 
 69
digestive system, larvae L3 wandering
 
 108
digestive system, 1-day adult
 
 77
digestive system, 4-day adult
 
 38
digestive system, 20-day adult
 
 63
fat body, larvae L3 wandering
 
 228
fat body, white prepupae
 
 243
fat body, pupae P8
 
 13
carcass, larvae L3 wandering
 
 66
carcass, 1-day adult
 
 167
carcass, 4-day adult
 
 114
carcass, 20-day adult
 
 220
ovary, virgin 4-day female
 
 14
ovary, mated 4-day female
 
 13
testis, mated 4-day male
 
 13
accessory gland, mated 4-day male
 
 31
Expression Level Scale
 Extremely high 
log, scaled to maximum expression level
Tissue   Expression Level
imaginal disc, larvae L3 wandering
 
 60
central nervous system, larvae L3
 
 57
central nervous system, pupae P8
 
 2
head, virgin 1-day female
 
 48
head, virgin 4-day female
 
 106
head, virgin 20-day female
 
 238
head, mated 1-day female
 
 88
head, mated 4-day female
 
 51
head, mated 20-day female
 
 183
head, mated 1-day male
 
 42
head, mated 4-day male
 
 22
head, mated 20-day male
 
 56
salivary gland, larvae L3 wandering
 
 388
salivary gland, white prepupae
 
 69
digestive system, larvae L3 wandering
 
 108
digestive system, 1-day adult
 
 77
digestive system, 4-day adult
 
 38
digestive system, 20-day adult
 
 63
fat body, larvae L3 wandering
 
 228
fat body, white prepupae
 
 243
fat body, pupae P8
 
 13
carcass, larvae L3 wandering
 
 66
carcass, 1-day adult
 
 167
carcass, 4-day adult
 
 114
carcass, 20-day adult
 
 220
ovary, virgin 4-day female
 
 14
ovary, mated 4-day female
 
 13
testis, mated 4-day male
 
 13
accessory gland, mated 4-day male
 
 31
Expression Level Scale
 Very low 
 Low 
 Moderate 
 Moderately high 
 High 
 Very high 
log, scaled to Moderate expression
Tissue   Expression Level
imaginal disc, larvae L3 wandering
 (60)
central nervous system, larvae L3
 (57)
central nervous system, pupae P8
 
 2
head, virgin 1-day female
 (48)
head, virgin 4-day female
 (106)
head, virgin 20-day female
 (238)
head, mated 1-day female
 (88)
head, mated 4-day female
 (51)
head, mated 20-day female
 (183)
head, mated 1-day male
 (42)
head, mated 4-day male
 
 22
head, mated 20-day male
 (56)
salivary gland, larvae L3 wandering
 (388)
salivary gland, white prepupae
 (69)
digestive system, larvae L3 wandering
 (108)
digestive system, 1-day adult
 (77)
digestive system, 4-day adult
 (38)
digestive system, 20-day adult
 (63)
fat body, larvae L3 wandering
 (228)
fat body, white prepupae
 (243)
fat body, pupae P8
 
 13
carcass, larvae L3 wandering
 (66)
carcass, 1-day adult
 (167)
carcass, 4-day adult
 (114)
carcass, 20-day adult
 (220)
ovary, virgin 4-day female
 
 14
ovary, mated 4-day female
 
 13
testis, mated 4-day male
 
 13
accessory gland, mated 4-day male
 31
Expression Level Scale
 Very low 
 Low 
 Moderate 
 Moderately high 
log, scaled to High expression
Tissue   Expression Level
imaginal disc, larvae L3 wandering
 
 60
central nervous system, larvae L3
 
 57
central nervous system, pupae P8
 
 2
head, virgin 1-day female
 
 48
head, virgin 4-day female
 106
head, virgin 20-day female
 (238)
head, mated 1-day female
 
 88
head, mated 4-day female
 
 51
head, mated 20-day female
 (183)
head, mated 1-day male
 
 42
head, mated 4-day male
 
 22
head, mated 20-day male
 
 56
salivary gland, larvae L3 wandering
 (388)
salivary gland, white prepupae
 
 69
digestive system, larvae L3 wandering
 108
digestive system, 1-day adult
 
 77
digestive system, 4-day adult
 
 38
digestive system, 20-day adult
 
 63
fat body, larvae L3 wandering
 (228)
fat body, white prepupae
 (243)
fat body, pupae P8
 
 13
carcass, larvae L3 wandering
 
 66
carcass, 1-day adult
 (167)
carcass, 4-day adult
 114
carcass, 20-day adult
 (220)
ovary, virgin 4-day female
 
 14
ovary, mated 4-day female
 
 13
testis, mated 4-day male
 
 13
accessory gland, mated 4-day male
 
 31
Expression Level Scale
 Very low 
 Low 
 Moderate 
 Moderately high 
 High 
 Very high 
log, scaled to Extremely high expression
Tissue   Expression Level
imaginal disc, larvae L3 wandering
 
 60
central nervous system, larvae L3
 
 57
central nervous system, pupae P8
 
 2
head, virgin 1-day female
 
 48
head, virgin 4-day female
 
 106
head, virgin 20-day female
 
 238
head, mated 1-day female
 
 88
head, mated 4-day female
 
 51
head, mated 20-day female
 
 183
head, mated 1-day male
 
 42
head, mated 4-day male
 
 22
head, mated 20-day male
 
 56
salivary gland, larvae L3 wandering
 
 388
salivary gland, white prepupae
 
 69
digestive system, larvae L3 wandering
 
 108
digestive system, 1-day adult
 
 77
digestive system, 4-day adult
 
 38
digestive system, 20-day adult
 
 63
fat body, larvae L3 wandering
 
 228
fat body, white prepupae
 
 243
fat body, pupae P8
 
 13
carcass, larvae L3 wandering
 
 66
carcass, 1-day adult
 
 167
carcass, 4-day adult
 
 114
carcass, 20-day adult
 
 220
ovary, virgin 4-day female
 
 14
ovary, mated 4-day female
 
 13
testis, mated 4-day male
 
 13
accessory gland, mated 4-day male
 
 31
Expression Level Scale
 Very low 
 Low 
 Moderate 
 Moderately high 
 High 
 Very high 
 Extremely high 
Heatmap
Tissue   Expression Level
imaginal disc, larvae L3 wandering
 
 
central nervous system, larvae L3
 
 
central nervous system, pupae P8
 
 
head, virgin 1-day female
 
 
head, virgin 4-day female
 
 
head, virgin 20-day female
 
 
head, mated 1-day female
 
 
head, mated 4-day female
 
 
head, mated 20-day female
 
 
head, mated 1-day male
 
 
head, mated 4-day male
 
 
head, mated 20-day male
 
 
salivary gland, larvae L3 wandering
 
 
salivary gland, white prepupae
 
 
digestive system, larvae L3 wandering
 
 
digestive system, 1-day adult
 
 
digestive system, 4-day adult
 
 
digestive system, 20-day adult
 
 
fat body, larvae L3 wandering
 
 
fat body, white prepupae
 
 
fat body, pupae P8
 
 
carcass, larvae L3 wandering
 
 
carcass, 1-day adult
 
 
carcass, 4-day adult
 
 
carcass, 20-day adult
 
 
ovary, virgin 4-day female
 
 
ovary, mated 4-day female
 
 
testis, mated 4-day male
 
 
accessory gland, mated 4-day male
 
 

hide modENCODE Development RNA-Seq

modENCODE Temporal Expression Data

(modENCODE_mRNA-Seq_U)


   Styles
   Scales

Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of very high expression to a trough of moderate expression. Peak expression observed within 18-24 hour embryonic stages, at stages throughout the larval period, during early pupal stages, in stages of adults of both sexes.
[download data (TSV)]

Guide to modENCODE expression level colors
 
 No/Extremely low expression (0 - 0)
 
 Very low expression (1 - 3)
 
 Low expression (4 - 10)
 
 Moderate expression (11 - 25)
 
 Moderately high expression (26 - 50)
 
 High expression (51 - 100)
 
 Very high expression (101 - 1000)
 
 Extremely high expression (>1000)

Linear, scaled to maximum expression level
Developmental Stage   Expression Level
embryo 00-02hr
 
 15
embryo 02-04hr
 
 33
embryo 04-06hr
 
 100
embryo 06-08hr
 
 88
embryo 08-10hr
 
 61
embryo 10-12hr
 
 77
embryo 12-14hr
 
 101
embryo 14-16hr
 
 112
embryo 16-18hr
 
 126
embryo 18-20hr
 
 341
embryo 20-22hr
 
 323
embryo 22-24hr
 
 371
larva L1
 
 121
larva L2
 
 86
larva L3 12hr old
 
 195
larva L3 puffstage 1-2
 
 327
larva L3 puffstage 3-6
 
 697
larva L3 puffstage 7-9
 
 701
white prepupae new
 
 305
white prepupae 12hr
 
 651
white prepupae 24hr
 
 115
pupae 2d postWPP
 
 106
pupae 3d postWPP
 
 60
pupae 4d postWPP
 
 102
adult male 01day
 
 204
adult male 05day
 
 220
adult male 30day
 
 244
adult female 01day
 
 191
adult female 05day
 
 139
adult female 30day
 
 110
Expression Level Scale
 Very low 
 Low 
 Moderate 
 Moderately high 
 High 
 Very high 
Linear, scaled to Moderate expression
Developmental Stage   Expression Level
embryo 00-02hr
 
 15
embryo 02-04hr
 (33)
embryo 04-06hr
 (100)
embryo 06-08hr
 (88)
embryo 08-10hr
 (61)
embryo 10-12hr
 (77)
embryo 12-14hr
 (101)
embryo 14-16hr
 (112)
embryo 16-18hr
 (126)
embryo 18-20hr
 (341)
embryo 20-22hr
 (323)
embryo 22-24hr
 (371)
larva L1
 (121)
larva L2
 (86)
larva L3 12hr old
 (195)
larva L3 puffstage 1-2
 (327)
larva L3 puffstage 3-6
 (697)
larva L3 puffstage 7-9
 (701)
white prepupae new
 (305)
white prepupae 12hr
 (651)
white prepupae 24hr
 (115)
pupae 2d postWPP
 (106)
pupae 3d postWPP
 (60)
pupae 4d postWPP
 (102)
adult male 01day
 (204)
adult male 05day
 (220)
adult male 30day
 (244)
adult female 01day
 (191)
adult female 05day
 (139)
adult female 30day
 (110)
Expression Level Scale
 Very low 
 Low 
 Moderate 
 Moderately high 
Linear, scaled to High expression
Developmental Stage   Expression Level
embryo 00-02hr
 
 15
embryo 02-04hr
 
 33
embryo 04-06hr
 
 100
embryo 06-08hr
 
 88
embryo 08-10hr
 
 61
embryo 10-12hr
 
 77
embryo 12-14hr
 101
embryo 14-16hr
 (112)
embryo 16-18hr
 (126)
embryo 18-20hr
 (341)
embryo 20-22hr
 (323)
embryo 22-24hr
 (371)
larva L1
 (121)
larva L2
 
 86
larva L3 12hr old
 (195)
larva L3 puffstage 1-2
 (327)
larva L3 puffstage 3-6
 (697)
larva L3 puffstage 7-9
 (701)
white prepupae new
 (305)
white prepupae 12hr
 (651)
white prepupae 24hr
 (115)
pupae 2d postWPP
 106
pupae 3d postWPP
 
 60
pupae 4d postWPP
 102
adult male 01day
 (204)
adult male 05day
 (220)
adult male 30day
 (244)
adult female 01day
 (191)
adult female 05day
 (139)
adult female 30day
 (110)
Expression Level Scale
 Very low 
 Low 
 Moderate 
 Moderately high 
 High 
 Very high 
Linear, scaled to Extremely high expression
Developmental Stage   Expression Level
embryo 00-02hr
 
 15
embryo 02-04hr
 
 33
embryo 04-06hr
 
 100
embryo 06-08hr
 
 88
embryo 08-10hr
 
 61
embryo 10-12hr
 
 77
embryo 12-14hr
 
 101
embryo 14-16hr
 
 112
embryo 16-18hr
 
 126
embryo 18-20hr
 
 341
embryo 20-22hr
 
 323
embryo 22-24hr
 
 371
larva L1
 
 121
larva L2
 
 86
larva L3 12hr old
 
 195
larva L3 puffstage 1-2
 
 327
larva L3 puffstage 3-6
 
 697
larva L3 puffstage 7-9
 
 701
white prepupae new
 
 305
white prepupae 12hr
 
 651
white prepupae 24hr
 
 115
pupae 2d postWPP
 
 106
pupae 3d postWPP
 
 60
pupae 4d postWPP
 
 102
adult male 01day
 
 204
adult male 05day
 
 220
adult male 30day
 
 244
adult female 01day
 
 191
adult female 05day
 
 139
adult female 30day
 
 110
Expression Level Scale
 Extremely high 
log, scaled to maximum expression level
Developmental Stage   Expression Level
embryo 00-02hr
 
 15
embryo 02-04hr
 
 33
embryo 04-06hr
 
 100
embryo 06-08hr
 
 88
embryo 08-10hr
 
 61
embryo 10-12hr
 
 77
embryo 12-14hr
 
 101
embryo 14-16hr
 
 112
embryo 16-18hr
 
 126
embryo 18-20hr
 
 341
embryo 20-22hr
 
 323
embryo 22-24hr
 
 371
larva L1
 
 121
larva L2
 
 86
larva L3 12hr old
 
 195
larva L3 puffstage 1-2
 
 327
larva L3 puffstage 3-6
 
 697
larva L3 puffstage 7-9
 
 701
white prepupae new
 
 305
white prepupae 12hr
 
 651
white prepupae 24hr
 
 115
pupae 2d postWPP
 
 106
pupae 3d postWPP
 
 60
pupae 4d postWPP
 
 102
adult male 01day
 
 204
adult male 05day
 
 220
adult male 30day
 
 244
adult female 01day
 
 191
adult female 05day
 
 139
adult female 30day
 
 110
Expression Level Scale
 Very low 
 Low 
 Moderate 
 Moderately high 
 High 
 Very high 
 Extremely high 
log, scaled to Moderate expression
Developmental Stage   Expression Level
embryo 00-02hr
 
 15
embryo 02-04hr
 (33)
embryo 04-06hr
 (100)
embryo 06-08hr
 (88)
embryo 08-10hr
 (61)
embryo 10-12hr
 (77)
embryo 12-14hr
 (101)
embryo 14-16hr
 (112)
embryo 16-18hr
 (126)
embryo 18-20hr
 (341)
embryo 20-22hr
 (323)
embryo 22-24hr
 (371)
larva L1
 (121)
larva L2
 (86)
larva L3 12hr old
 (195)
larva L3 puffstage 1-2
 (327)
larva L3 puffstage 3-6
 (697)
larva L3 puffstage 7-9
 (701)
white prepupae new
 (305)
white prepupae 12hr
 (651)
white prepupae 24hr
 (115)
pupae 2d postWPP
 (106)
pupae 3d postWPP
 (60)
pupae 4d postWPP
 (102)
adult male 01day
 (204)
adult male 05day
 (220)
adult male 30day
 (244)
adult female 01day
 (191)
adult female 05day
 (139)
adult female 30day
 (110)
Expression Level Scale
 Very low 
 Low 
 Moderate 
 Moderately high 
log, scaled to High expression
Developmental Stage   Expression Level
embryo 00-02hr
 
 15
embryo 02-04hr
 
 33
embryo 04-06hr
 
 100
embryo 06-08hr
 
 88
embryo 08-10hr
 
 61
embryo 10-12hr
 
 77
embryo 12-14hr
 101
embryo 14-16hr
 112
embryo 16-18hr
 126
embryo 18-20hr
 (341)
embryo 20-22hr
 (323)
embryo 22-24hr
 (371)
larva L1
 121
larva L2
 
 86
larva L3 12hr old
 (195)
larva L3 puffstage 1-2
 (327)
larva L3 puffstage 3-6
 (697)
larva L3 puffstage 7-9
 (701)
white prepupae new
 (305)
white prepupae 12hr
 (651)
white prepupae 24hr
 115
pupae 2d postWPP
 106
pupae 3d postWPP
 
 60
pupae 4d postWPP
 102
adult male 01day
 (204)
adult male 05day
 (220)
adult male 30day
 (244)
adult female 01day
 (191)
adult female 05day
 139
adult female 30day
 110
Expression Level Scale
 Very low 
 Low 
 Moderate 
 Moderately high 
 High 
 Very high 
log, scaled to Extremely high expression
Developmental Stage   Expression Level
embryo 00-02hr
 
 15
embryo 02-04hr
 
 33
embryo 04-06hr
 
 100
embryo 06-08hr
 
 88
embryo 08-10hr
 
 61
embryo 10-12hr
 
 77
embryo 12-14hr
 
 101
embryo 14-16hr
 
 112
embryo 16-18hr
 
 126
embryo 18-20hr
 
 341
embryo 20-22hr
 
 323
embryo 22-24hr
 
 371
larva L1
 
 121
larva L2
 
 86
larva L3 12hr old
 
 195
larva L3 puffstage 1-2
 
 327
larva L3 puffstage 3-6
 
 697
larva L3 puffstage 7-9
 
 701
white prepupae new
 
 305
white prepupae 12hr
 
 651
white prepupae 24hr
 
 115
pupae 2d postWPP
 
 106
pupae 3d postWPP
 
 60
pupae 4d postWPP
 
 102
adult male 01day
 
 204
adult male 05day
 
 220
adult male 30day
 
 244
adult female 01day
 
 191
adult female 05day
 
 139
adult female 30day
 
 110
Expression Level Scale
 Very low 
 Low 
 Moderate 
 Moderately high 
 High 
 Very high 
 Extremely high 
Heatmap
Developmental Stage   Expression Level
embryo 00-02hr
 
 
embryo 02-04hr
 
 
embryo 04-06hr
 
 
embryo 06-08hr
 
 
embryo 08-10hr
 
 
embryo 10-12hr
 
 
embryo 12-14hr
 
 
embryo 14-16hr
 
 
embryo 16-18hr
 
 
embryo 18-20hr
 
 
embryo 20-22hr
 
 
embryo 22-24hr
 
 
larva L1
 
 
larva L2
 
 
larva L3 12hr old
 
 
larva L3 puffstage 1-2
 
 
larva L3 puffstage 3-6
 
 
larva L3 puffstage 7-9
 
 
white prepupae new
 
 
white prepupae 12hr
 
 
white prepupae 24hr
 
 
pupae 2d postWPP
 
 
pupae 3d postWPP
 
 
pupae 4d postWPP
 
 
adult male 01day
 
 
adult male 05day
 
 
adult male 30day
 
 
adult female 01day
 
 
adult female 05day
 
 
adult female 30day
 
 

modENCODE Temporal Expression Data (Graveley et al., 2011)
hide modENCODE Cell Lines RNA-Seq

modENCODE Cell Line Expression Data

(modENCODE_mRNA-Seq_cell.A)

(modENCODE_mRNA-Seq_cell.B)


   Styles
   Scales


[download data (TSV)]

Guide to modENCODE expression level colors
 
 No/Extremely low expression (0 - 0)
 
 Very low expression (1 - 3)
 
 Low expression (4 - 10)
 
 Moderate expression (11 - 25)
 
 Moderately high expression (26 - 50)
 
 High expression (51 - 100)
 
 Very high expression (101 - 1000)
 
 Extremely high expression (>1000)

Linear, scaled to maximum expression level
Cell Line   Expression Level
Schneider line 2 S2R+
 
 35
Schneider line 2 Sg4
 
 61
embryonic 1182-4H
 
 31
embryonic GM2
 
 119
embryonic Kc167
 
 50
embryonic S1
 
 64
embryonic S3
 
 29
leg disc CME L1
 
 76
wing disc CME-W2
 
 78
wing disc ML-DmD8
 
 19
wing disc ML-DmD9
 
 67
wing disc ML-DmD16-c3
 
 32
wing disc ML-DmD21
 
 24
wing disc ML-DmD32
 
 84
haltere disc ML-DmD17-c3
 
 8
eye-antennal disc ML-DmD11
 
 55
antennal disc ML-DmD20-c5
 
 33
mixed discs ML-DmD4-c1
 
 32
CNS ML-DmBG1-c1
 
 27
CNS ML-DmBG2-c2
 
 256
tumorous blood cells mbn2
 
 259
ovary fGS/OSS
 
 109
ovary OSC
 
 23
ovary OSS
 
 8
Expression Level Scale
 Very low 
 Low 
 Moderate 
 Moderately high 
 High 
 Very high 
Linear, scaled to Moderate expression
Cell Line   Expression Level
Schneider line 2 S2R+
 (35)
Schneider line 2 Sg4
 (61)
embryonic 1182-4H
 (31)
embryonic GM2
 (119)
embryonic Kc167
 (50)
embryonic S1
 (64)
embryonic S3
 (29)
leg disc CME L1
 (76)
wing disc CME-W2
 (78)
wing disc ML-DmD8
 
 19
wing disc ML-DmD9
 (67)
wing disc ML-DmD16-c3
 (32)
wing disc ML-DmD21
 
 24
wing disc ML-DmD32
 (84)
haltere disc ML-DmD17-c3
 
 8
eye-antennal disc ML-DmD11
 (55)
antennal disc ML-DmD20-c5
 (33)
mixed discs ML-DmD4-c1
 (32)
CNS ML-DmBG1-c1
 (27)
CNS ML-DmBG2-c2
 (256)
tumorous blood cells mbn2
 (259)
ovary fGS/OSS
 (109)
ovary OSC
 
 23
ovary OSS
 
 8
Expression Level Scale
 Very low 
 Low 
 Moderate 
 Moderately high 
Linear, scaled to High expression
Cell Line   Expression Level
Schneider line 2 S2R+
 
 35
Schneider line 2 Sg4
 
 61
embryonic 1182-4H
 
 31
embryonic GM2
 (119)
embryonic Kc167
 
 50
embryonic S1
 
 64
embryonic S3
 
 29
leg disc CME L1
 
 76
wing disc CME-W2
 
 78
wing disc ML-DmD8
 
 19
wing disc ML-DmD9
 
 67
wing disc ML-DmD16-c3
 
 32
wing disc ML-DmD21
 
 24
wing disc ML-DmD32
 
 84
haltere disc ML-DmD17-c3
 
 8
eye-antennal disc ML-DmD11
 
 55
antennal disc ML-DmD20-c5
 
 33
mixed discs ML-DmD4-c1
 
 32
CNS ML-DmBG1-c1
 
 27
CNS ML-DmBG2-c2
 (256)
tumorous blood cells mbn2
 (259)
ovary fGS/OSS
 (109)
ovary OSC
 
 23
ovary OSS
 
 8
Expression Level Scale
 Very low 
 Low 
 Moderate 
 Moderately high 
 High 
 Very high 
Linear, scaled to Extremely high expression
Cell Line   Expression Level
Schneider line 2 S2R+
 
 35
Schneider line 2 Sg4
 
 61
embryonic 1182-4H
 
 31
embryonic GM2
 
 119
embryonic Kc167
 
 50
embryonic S1
 
 64
embryonic S3
 
 29
leg disc CME L1
 
 76
wing disc CME-W2
 
 78
wing disc ML-DmD8
 
 19
wing disc ML-DmD9
 
 67
wing disc ML-DmD16-c3
 
 32
wing disc ML-DmD21
 
 24
wing disc ML-DmD32
 
 84
haltere disc ML-DmD17-c3
 
 8
eye-antennal disc ML-DmD11
 
 55
antennal disc ML-DmD20-c5
 
 33
mixed discs ML-DmD4-c1
 
 32
CNS ML-DmBG1-c1
 
 27
CNS ML-DmBG2-c2
 
 256
tumorous blood cells mbn2
 
 259
ovary fGS/OSS
 
 109
ovary OSC
 
 23
ovary OSS
 
 8
Expression Level Scale
 Extremely high 
log, scaled to maximum expression level
Cell Line   Expression Level
Schneider line 2 S2R+
 
 35
Schneider line 2 Sg4
 
 61
embryonic 1182-4H
 
 31
embryonic GM2
 
 119
embryonic Kc167
 
 50
embryonic S1
 
 64
embryonic S3
 
 29
leg disc CME L1
 
 76
wing disc CME-W2
 
 78
wing disc ML-DmD8
 
 19
wing disc ML-DmD9
 
 67
wing disc ML-DmD16-c3
 
 32
wing disc ML-DmD21
 
 24
wing disc ML-DmD32
 
 84
haltere disc ML-DmD17-c3
 
 8
eye-antennal disc ML-DmD11
 
 55
antennal disc ML-DmD20-c5
 
 33
mixed discs ML-DmD4-c1
 
 32
CNS ML-DmBG1-c1
 
 27
CNS ML-DmBG2-c2
 
 256
tumorous blood cells mbn2
 
 259
ovary fGS/OSS
 
 109
ovary OSC
 
 23
ovary OSS
 
 8
Expression Level Scale
 Very low 
 Low 
 Moderate 
 Moderately high 
 High 
 Very high 
log, scaled to Moderate expression
Cell Line   Expression Level
Schneider line 2 S2R+
 (35)
Schneider line 2 Sg4
 (61)
embryonic 1182-4H
 31
embryonic GM2
 (119)
embryonic Kc167
 (50)
embryonic S1
 (64)
embryonic S3
 29
leg disc CME L1
 (76)
wing disc CME-W2
 (78)
wing disc ML-DmD8
 
 19
wing disc ML-DmD9
 (67)
wing disc ML-DmD16-c3
 32
wing disc ML-DmD21
 
 24
wing disc ML-DmD32
 (84)
haltere disc ML-DmD17-c3
 
 8
eye-antennal disc ML-DmD11
 (55)
antennal disc ML-DmD20-c5
 (33)
mixed discs ML-DmD4-c1
 32
CNS ML-DmBG1-c1
 27
CNS ML-DmBG2-c2
 (256)
tumorous blood cells mbn2
 (259)
ovary fGS/OSS
 (109)
ovary OSC
 
 23
ovary OSS
 
 8
Expression Level Scale
 Very low 
 Low 
 Moderate 
 Moderately high 
log, scaled to High expression
Cell Line   Expression Level
Schneider line 2 S2R+
 
 35
Schneider line 2 Sg4
 
 61
embryonic 1182-4H
 
 31
embryonic GM2
 119
embryonic Kc167
 
 50
embryonic S1
 
 64
embryonic S3
 
 29
leg disc CME L1
 
 76
wing disc CME-W2
 
 78
wing disc ML-DmD8
 
 19
wing disc ML-DmD9
 
 67
wing disc ML-DmD16-c3
 
 32
wing disc ML-DmD21
 
 24
wing disc ML-DmD32
 
 84
haltere disc ML-DmD17-c3
 
 8
eye-antennal disc ML-DmD11
 
 55
antennal disc ML-DmD20-c5
 
 33
mixed discs ML-DmD4-c1
 
 32
CNS ML-DmBG1-c1
 
 27
CNS ML-DmBG2-c2
 (256)
tumorous blood cells mbn2
 (259)
ovary fGS/OSS
 109
ovary OSC
 
 23
ovary OSS
 
 8
Expression Level Scale
 Very low 
 Low 
 Moderate 
 Moderately high 
 High 
 Very high 
log, scaled to Extremely high expression
Cell Line   Expression Level
Schneider line 2 S2R+
 
 35
Schneider line 2 Sg4
 
 61
embryonic 1182-4H
 
 31
embryonic GM2
 
 119
embryonic Kc167
 
 50
embryonic S1
 
 64
embryonic S3
 
 29
leg disc CME L1
 
 76
wing disc CME-W2
 
 78
wing disc ML-DmD8
 
 19
wing disc ML-DmD9
 
 67
wing disc ML-DmD16-c3
 
 32
wing disc ML-DmD21
 
 24
wing disc ML-DmD32
 
 84
haltere disc ML-DmD17-c3
 
 8
eye-antennal disc ML-DmD11
 
 55
antennal disc ML-DmD20-c5
 
 33
mixed discs ML-DmD4-c1
 
 32
CNS ML-DmBG1-c1
 
 27
CNS ML-DmBG2-c2
 
 256
tumorous blood cells mbn2
 
 259
ovary fGS/OSS
 
 109
ovary OSC
 
 23
ovary OSS
 
 8
Expression Level Scale
 Very low 
 Low 
 Moderate 
 Moderately high 
 High 
 Very high 
 Extremely high 
Heatmap
Cell Line   Expression Level
Schneider line 2 S2R+
 
 
Schneider line 2 Sg4
 
 
embryonic 1182-4H
 
 
embryonic GM2
 
 
embryonic Kc167
 
 
embryonic S1
 
 
embryonic S3
 
 
leg disc CME L1
 
 
wing disc CME-W2
 
 
wing disc ML-DmD8
 
 
wing disc ML-DmD9
 
 
wing disc ML-DmD16-c3
 
 
wing disc ML-DmD21
 
 
wing disc ML-DmD32
 
 
haltere disc ML-DmD17-c3
 
 
eye-antennal disc ML-DmD11
 
 
antennal disc ML-DmD20-c5
 
 
mixed discs ML-DmD4-c1
 
 
CNS ML-DmBG1-c1
 
 
CNS ML-DmBG2-c2
 
 
tumorous blood cells mbn2
 
 
ovary fGS/OSS
 
 
ovary OSC
 
 
ovary OSS
 
 

hide modENCODE Treatments RNA-Seq

modENCODE Treatment Expression Data

(modENCODE_mRNA-Seq_treatments)


   Styles
   Scales


[download data (TSV)]

Guide to modENCODE expression level colors
 
 No/Extremely low expression (0 - 0)
 
 Very low expression (1 - 3)
 
 Low expression (4 - 10)
 
 Moderate expression (11 - 25)
 
 Moderately high expression (26 - 50)
 
 High expression (51 - 100)
 
 Very high expression (101 - 1000)
 
 Extremely high expression (>1000)

Linear, scaled to maximum expression level
Treatment   Expression Level
extended cold, 4-day adult
 
 62
cold shock, 4-day adult
 
 42
heat shock, 4-day adult
 
 104
Cadmium 50 mM 6 hrs, larvae L3
 
 96
Cadmium 50 mM 12 hrs, larvae L3
 
 206
Cadmium 50 mM 48 hrs, 4-day adult
 
 191
Cadmium 100 mM 48 hrs, 4-day adult
 
 275
Copper 0.5 mM 12 hrs, larvae L3
 
 27
Copper 15 mM 48 hrs, 4-day adult
 
 137
Zinc 5 mM 12 hrs, larvae L3
 
 30
Zinc 4.5 mM 48 hrs, 4-day adult
 
 178
Ethanol 2.5% 3 hrs, larvae L3
 
 276
Ethanol 5% 3 hrs, larvae L3
 
 305
Ethanol 10% 3 hrs, larvae L3
 
 158
Caffeine 1.5 mg/ml 4 hrs, larvae L3
 
 334
Caffeine 2.5 mg/ml 48 hrs, 4-day adult
 
 298
Caffeine 25 mg/ml 48 hrs, 4-day adult
 
 59
Paraquat 5 mM 48 hrs, 4-day adult
 
 181
Paraquat 10 mM 48 hrs, 4-day adult
 
 458
Rotenone 2 μg 12 hrs, larvae L3
 
 162
Rotenone 8 μg 12 hrs, larvae L3
 
 136
Expression Level Scale
 Very low 
 Low 
 Moderate 
 Moderately high 
 High 
 Very high 
Linear, scaled to Moderate expression
Treatment   Expression Level
extended cold, 4-day adult
 (62)
cold shock, 4-day adult
 (42)
heat shock, 4-day adult
 (104)
Cadmium 50 mM 6 hrs, larvae L3
 (96)
Cadmium 50 mM 12 hrs, larvae L3
 (206)
Cadmium 50 mM 48 hrs, 4-day adult
 (191)
Cadmium 100 mM 48 hrs, 4-day adult
 (275)
Copper 0.5 mM 12 hrs, larvae L3
 (27)
Copper 15 mM 48 hrs, 4-day adult
 (137)
Zinc 5 mM 12 hrs, larvae L3
 (30)
Zinc 4.5 mM 48 hrs, 4-day adult
 (178)
Ethanol 2.5% 3 hrs, larvae L3
 (276)
Ethanol 5% 3 hrs, larvae L3
 (305)
Ethanol 10% 3 hrs, larvae L3
 (158)
Caffeine 1.5 mg/ml 4 hrs, larvae L3
 (334)
Caffeine 2.5 mg/ml 48 hrs, 4-day adult
 (298)
Caffeine 25 mg/ml 48 hrs, 4-day adult
 (59)
Paraquat 5 mM 48 hrs, 4-day adult
 (181)
Paraquat 10 mM 48 hrs, 4-day adult
 (458)
Rotenone 2 μg 12 hrs, larvae L3
 (162)
Rotenone 8 μg 12 hrs, larvae L3
 (136)
Expression Level Scale
 Very low 
 Low 
 Moderate 
 Moderately high 
Linear, scaled to High expression
Treatment   Expression Level
extended cold, 4-day adult
 
 62
cold shock, 4-day adult
 
 42
heat shock, 4-day adult
 104
Cadmium 50 mM 6 hrs, larvae L3
 
 96
Cadmium 50 mM 12 hrs, larvae L3
 (206)
Cadmium 50 mM 48 hrs, 4-day adult
 (191)
Cadmium 100 mM 48 hrs, 4-day adult
 (275)
Copper 0.5 mM 12 hrs, larvae L3
 
 27
Copper 15 mM 48 hrs, 4-day adult
 (137)
Zinc 5 mM 12 hrs, larvae L3
 
 30
Zinc 4.5 mM 48 hrs, 4-day adult
 (178)
Ethanol 2.5% 3 hrs, larvae L3
 (276)
Ethanol 5% 3 hrs, larvae L3
 (305)
Ethanol 10% 3 hrs, larvae L3
 (158)
Caffeine 1.5 mg/ml 4 hrs, larvae L3
 (334)
Caffeine 2.5 mg/ml 48 hrs, 4-day adult
 (298)
Caffeine 25 mg/ml 48 hrs, 4-day adult
 
 59
Paraquat 5 mM 48 hrs, 4-day adult
 (181)
Paraquat 10 mM 48 hrs, 4-day adult
 (458)
Rotenone 2 μg 12 hrs, larvae L3
 (162)
Rotenone 8 μg 12 hrs, larvae L3
 (136)
Expression Level Scale
 Very low 
 Low 
 Moderate 
 Moderately high 
 High 
 Very high 
Linear, scaled to Extremely high expression
Treatment   Expression Level
extended cold, 4-day adult
 
 62
cold shock, 4-day adult
 
 42
heat shock, 4-day adult
 
 104
Cadmium 50 mM 6 hrs, larvae L3
 
 96
Cadmium 50 mM 12 hrs, larvae L3
 
 206
Cadmium 50 mM 48 hrs, 4-day adult
 
 191
Cadmium 100 mM 48 hrs, 4-day adult
 
 275
Copper 0.5 mM 12 hrs, larvae L3
 
 27
Copper 15 mM 48 hrs, 4-day adult
 
 137
Zinc 5 mM 12 hrs, larvae L3
 
 30
Zinc 4.5 mM 48 hrs, 4-day adult
 
 178
Ethanol 2.5% 3 hrs, larvae L3
 
 276
Ethanol 5% 3 hrs, larvae L3
 
 305
Ethanol 10% 3 hrs, larvae L3
 
 158
Caffeine 1.5 mg/ml 4 hrs, larvae L3
 
 334
Caffeine 2.5 mg/ml 48 hrs, 4-day adult
 
 298
Caffeine 25 mg/ml 48 hrs, 4-day adult
 
 59
Paraquat 5 mM 48 hrs, 4-day adult
 
 181
Paraquat 10 mM 48 hrs, 4-day adult
 
 458
Rotenone 2 μg 12 hrs, larvae L3
 
 162
Rotenone 8 μg 12 hrs, larvae L3
 
 136
Expression Level Scale
 Extremely high 
log, scaled to maximum expression level
Treatment   Expression Level
extended cold, 4-day adult
 
 62
cold shock, 4-day adult
 
 42
heat shock, 4-day adult
 
 104
Cadmium 50 mM 6 hrs, larvae L3
 
 96
Cadmium 50 mM 12 hrs, larvae L3
 
 206
Cadmium 50 mM 48 hrs, 4-day adult
 
 191
Cadmium 100 mM 48 hrs, 4-day adult
 
 275
Copper 0.5 mM 12 hrs, larvae L3
 
 27
Copper 15 mM 48 hrs, 4-day adult
 
 137
Zinc 5 mM 12 hrs, larvae L3
 
 30
Zinc 4.5 mM 48 hrs, 4-day adult
 
 178
Ethanol 2.5% 3 hrs, larvae L3
 
 276
Ethanol 5% 3 hrs, larvae L3
 
 305
Ethanol 10% 3 hrs, larvae L3
 
 158
Caffeine 1.5 mg/ml 4 hrs, larvae L3
 
 334
Caffeine 2.5 mg/ml 48 hrs, 4-day adult
 
 298
Caffeine 25 mg/ml 48 hrs, 4-day adult
 
 59
Paraquat 5 mM 48 hrs, 4-day adult
 
 181
Paraquat 10 mM 48 hrs, 4-day adult
 
 458
Rotenone 2 μg 12 hrs, larvae L3
 
 162
Rotenone 8 μg 12 hrs, larvae L3
 
 136
Expression Level Scale
 Very low 
 Low 
 Moderate 
 Moderately high 
 High 
 Very high 
log, scaled to Moderate expression
Treatment   Expression Level
extended cold, 4-day adult
 (62)
cold shock, 4-day adult
 (42)
heat shock, 4-day adult
 (104)
Cadmium 50 mM 6 hrs, larvae L3
 (96)
Cadmium 50 mM 12 hrs, larvae L3
 (206)
Cadmium 50 mM 48 hrs, 4-day adult
 (191)
Cadmium 100 mM 48 hrs, 4-day adult
 (275)
Copper 0.5 mM 12 hrs, larvae L3
 27
Copper 15 mM 48 hrs, 4-day adult
 (137)
Zinc 5 mM 12 hrs, larvae L3
 30
Zinc 4.5 mM 48 hrs, 4-day adult
 (178)
Ethanol 2.5% 3 hrs, larvae L3
 (276)
Ethanol 5% 3 hrs, larvae L3
 (305)
Ethanol 10% 3 hrs, larvae L3
 (158)
Caffeine 1.5 mg/ml 4 hrs, larvae L3
 (334)
Caffeine 2.5 mg/ml 48 hrs, 4-day adult
 (298)
Caffeine 25 mg/ml 48 hrs, 4-day adult
 (59)
Paraquat 5 mM 48 hrs, 4-day adult
 (181)
Paraquat 10 mM 48 hrs, 4-day adult
 (458)
Rotenone 2 μg 12 hrs, larvae L3
 (162)
Rotenone 8 μg 12 hrs, larvae L3
 (136)
Expression Level Scale
 Very low 
 Low 
 Moderate 
 Moderately high 
log, scaled to High expression
Treatment   Expression Level
extended cold, 4-day adult
 
 62
cold shock, 4-day adult
 
 42
heat shock, 4-day adult
 104
Cadmium 50 mM 6 hrs, larvae L3
 
 96
Cadmium 50 mM 12 hrs, larvae L3
 (206)
Cadmium 50 mM 48 hrs, 4-day adult
 (191)
Cadmium 100 mM 48 hrs, 4-day adult
 (275)
Copper 0.5 mM 12 hrs, larvae L3
 
 27
Copper 15 mM 48 hrs, 4-day adult
 137
Zinc 5 mM 12 hrs, larvae L3
 
 30
Zinc 4.5 mM 48 hrs, 4-day adult
 (178)
Ethanol 2.5% 3 hrs, larvae L3
 (276)
Ethanol 5% 3 hrs, larvae L3
 (305)
Ethanol 10% 3 hrs, larvae L3
 (158)
Caffeine 1.5 mg/ml 4 hrs, larvae L3
 (334)
Caffeine 2.5 mg/ml 48 hrs, 4-day adult
 (298)
Caffeine 25 mg/ml 48 hrs, 4-day adult
 
 59
Paraquat 5 mM 48 hrs, 4-day adult
 (181)
Paraquat 10 mM 48 hrs, 4-day adult
 (458)
Rotenone 2 μg 12 hrs, larvae L3
 (162)
Rotenone 8 μg 12 hrs, larvae L3
 136
Expression Level Scale
 Very low 
 Low 
 Moderate 
 Moderately high 
 High 
 Very high 
log, scaled to Extremely high expression
Treatment   Expression Level
extended cold, 4-day adult
 
 62
cold shock, 4-day adult
 
 42
heat shock, 4-day adult
 
 104
Cadmium 50 mM 6 hrs, larvae L3
 
 96
Cadmium 50 mM 12 hrs, larvae L3
 
 206
Cadmium 50 mM 48 hrs, 4-day adult
 
 191
Cadmium 100 mM 48 hrs, 4-day adult
 
 275
Copper 0.5 mM 12 hrs, larvae L3
 
 27
Copper 15 mM 48 hrs, 4-day adult
 
 137
Zinc 5 mM 12 hrs, larvae L3
 
 30
Zinc 4.5 mM 48 hrs, 4-day adult
 
 178
Ethanol 2.5% 3 hrs, larvae L3
 
 276
Ethanol 5% 3 hrs, larvae L3
 
 305
Ethanol 10% 3 hrs, larvae L3
 
 158
Caffeine 1.5 mg/ml 4 hrs, larvae L3
 
 334
Caffeine 2.5 mg/ml 48 hrs, 4-day adult
 
 298
Caffeine 25 mg/ml 48 hrs, 4-day adult
 
 59
Paraquat 5 mM 48 hrs, 4-day adult
 
 181
Paraquat 10 mM 48 hrs, 4-day adult
 
 458
Rotenone 2 μg 12 hrs, larvae L3
 
 162
Rotenone 8 μg 12 hrs, larvae L3
 
 136
Expression Level Scale
 Very low 
 Low 
 Moderate 
 Moderately high 
 High 
 Very high 
 Extremely high 
Heatmap
Treatment   Expression Level
extended cold, 4-day adult
 
 
cold shock, 4-day adult
 
 
heat shock, 4-day adult
 
 
Cadmium 50 mM 6 hrs, larvae L3
 
 
Cadmium 50 mM 12 hrs, larvae L3
 
 
Cadmium 50 mM 48 hrs, 4-day adult
 
 
Cadmium 100 mM 48 hrs, 4-day adult
 
 
Copper 0.5 mM 12 hrs, larvae L3
 
 
Copper 15 mM 48 hrs, 4-day adult
 
 
Zinc 5 mM 12 hrs, larvae L3
 
 
Zinc 4.5 mM 48 hrs, 4-day adult
 
 
Ethanol 2.5% 3 hrs, larvae L3
 
 
Ethanol 5% 3 hrs, larvae L3
 
 
Ethanol 10% 3 hrs, larvae L3
 
 
Caffeine 1.5 mg/ml 4 hrs, larvae L3
 
 
Caffeine 2.5 mg/ml 48 hrs, 4-day adult
 
 
Caffeine 25 mg/ml 48 hrs, 4-day adult
 
 
Paraquat 5 mM 48 hrs, 4-day adult
 
 
Paraquat 10 mM 48 hrs, 4-day adult
 
 
Rotenone 2 μg 12 hrs, larvae L3
 
 
Rotenone 8 μg 12 hrs, larvae L3
 
 

hide Expression Clusters
A cluster of genes with similar mRNA expression dynamics across development.
(Graveley et al., 2011)
hide External Data & Images
Linkouts
BDGP expression data
•
FLIGHT - Cell culture data for RNAi and other high-throughput technologies
•
hide Alleles & Phenotypes
hide Summary of Allele Phenotypes
Lethality
Allele
lethal | recessive
viable
viable, with Scer\GAL4pnr-MD237
Sterility
Allele
fertile
Other Phenotypes
Allele
aging defective
aging defective, with Scer\GAL4arm.PS
aging defective, with Scer\GAL4Mhc.PW
cell size defective, with Scer\GAL4Act5C.PP
chemical resistant, with Scer\GAL4da.G32
chemical sensitive
decreased cell number, with Scer\GAL4Bx-MS1096
decreased cell number | somatic clone, with Scer\GAL4Act5C.PP
decreased cell size | somatic clone, with Scer\GAL4Act5C.PP
feeding behavior defective, with Scer\GAL4Mhc.PW
immune response defective
long lived, with Scer\GAL4Mhc.PW
neuroanatomy defective, with Scer\GAL4Mhc.PW
short lived
short lived, with Scer\GAL4hs.PB
stress response defective
stress response defective, with Scer\GAL4arm.PS
visible, with Scer\GAL4Bx-MS1096
visible, with Scer\GAL4dpp.blk1
visible, with Scer\GAL4en-e16E
wild-type
Phenotype manifest in
Allele
1st posterior cell, with Scer\GAL4dpp.blk1
abdominal adult fat mass, with Scer\GAL4Mhc.PW
adult brain, with Scer\GAL4Mhc.PW
embryonic/larval fat body, with Scer\GAL4Act5C.PP
muscle cell, with Scer\GAL4Mhc.PW
retina, with Scer\GAL4Mhc.PW
type I bouton, with Scer\GAL4Mhc.PW
wing, with Scer\GAL4Bx-MS1096
wing, with Scer\GAL4en-e16E
wing disc, with Scer\GAL4Bx-MS1096
wing disc | somatic clone, with Scer\GAL4Act5C.PP
hide Classical Alleles ( 15 )
For All Classical Alleles Show

Allele of ThorClassMutagenStocksKnown lesion
Thork077362 --
Thor062701 --
Thor2loss of function allele1 Yes
Thork13517hypomorphic allele - genetic evidence1 Yes
ThorNP0923
1 --
Thor1rv10 --
ThorCPTI0011370 Yes
ThorEP20200 --
ThorEP23500 Yes
ThorEP8180 Yes
ThorGX316310 --
Thork077300 --
Thork077390 --
ThorRv10 Yes
ThorΔ1034-26170 Yes
hide Alleles Carried on Transgenic Constructs ( 14 )
For All Alleles Carried on Transgenic Constructs Show

Allele of ThorClassMutagenStocksKnown lesion
ThorGD125332 Yes
ThorLL.Scer\UAS2 Yes
ThorScer\UAS.cMa2 Yes
ThorGL010341 Yes
ThorHMS015551 Yes
ThorKK1082721 Yes
ThorAALL.Act5C0 Yes
ThorLL.Act5C0 Yes
ThorScer\UAS.cTa0 Yes
ThorScer\UAS.cTb0 Yes
ThorT37A.T46A.Scer\UAS0 Yes
ThorTA.Scer\UAS0 Yes
ThorTE.Scer\UAS0 Yes
ThorY54A.M59A.Scer\UAS0 Yes
hide Aneuploid Aberrations
Not disrupted in
(BDGP Project Members, 1994-1999)
(BDGP Project Members, 1994-1999)
(BDGP Project Members, 1994-1999)
(Spradling et al., 1999, BDGP Project Members, 1994-1999)
Disrupted in
(Ryder, 2004.4.26)
hide Transgenic Constructs & Insertions
Transgenic Constructs
Type of construct
Name
Expression data
UAS construct
P{GD12533}
NA
P{KK108272}
NA
P{TRiP.GL01034}
NA
P{TRiP.HMS01555}
NA
P{UAS-Thor.LL}
NA
P{UAS-Thor.T37A.T46A}
NA
P{UAS-Thor.T}
NA
P{UAS-Thor.TA}
NA
P{UAS-Thor.TE}
NA
P{UAS-Thor.wt}
NA
P{UAS-Thor.Y54A.M59A}
NA
P{UAS-Thor-HA}
NA
Insertions
Type of insertions
Name
Expression data
insertion of mobile activating element
P{EP}EP1010
NA
P{EP}EP2085
NA
P{EP}EP2244
NA
P{EP}EP2255
NA
P{EP}EP2266
NA
P{EP}ThorEP818
NA
P{EP}ThorEP2020
NA
P{EP}ThorEP2350
NA
P{EP}ThorGX31631
NA
insertion of enhancer trap
P{lacW}l(2)SH0490SH0490
No
P{lacW}Thork07730
No
P{lacW}Thork07736
No
P{lacW}Thork07739
No
P{lacW}Thork13517
No
P{PZ}Thor06270
No
insertion of enhancer trap binary system
P{GawB}ThorNP0923
No
miscellaneous insertions
P{?'lacW}Thor2
NA
P{(loxP.en.8)w}10
NA
P{SUPor-P}KG08448
NA
P{UAST-YFP.Rab6.T26N}01
NA
P{UAST-YFP.RabX4.T40N}03
NA
PBac{681.P.FSVS-1}ThorCPTI001137
NA
hide Gene Ontology: Function, Process & Cellular Component ( 13 unique terms )
hide Terms Based on Experimental Evidence ( 11 terms )
Molecular Function
CV term
Evidence
References
eukaryotic initiation factor 4E binding
inferred from direct assay
(Miron et al., 2001)
inferred from physical interaction with eIF4E-3
(Hernandez et al., 2005)
inferred from physical interaction with eIF4E-4
(Hernandez et al., 2005)
inferred from physical interaction with eIF4E-5
(Hernandez et al., 2005)
inferred from physical interaction with eIF4E-7
(Hernandez et al., 2005)
inferred from physical interaction with eIF-4E
(Hernandez et al., 2005)
Biological Process
CV term
Evidence
References
antibacterial humoral response
inferred from mutant phenotype
(Bernal and Kimbrell, 2000)
determination of adult lifespan
inferred from direct assay
(Zid et al., 2009)
immune response
inferred from expression pattern AND inferred from mutant phenotype
(Bernal and Kimbrell, 2000)
negative regulation of cell size
inferred from mutant phenotype
(Cully et al., 2010)
regulation of cell growth
inferred from genetic interaction with Akt1 AND inferred from genetic interaction with Pi3K92E AND inferred from mutant phenotype
(Miron et al., 2001)
regulation of mitochondrial translation
inferred from direct assay
(Zid et al., 2009)
response to oxidative stress
inferred from mutant phenotype
(Tettweiler et al., 2005)
response to starvation
inferred from direct assay
(Zid et al., 2009)
inferred from mutant phenotype
(Tettweiler et al., 2005)
response to stress
inferred from expression pattern
(Junger et al., 2003)
triglyceride metabolic process
inferred from mutant phenotype
(Teleman et al., 2005)
Cellular Component ( 0 terms)
hide Terms Based on Predictions or Assertions ( 5 terms )
Molecular Function
CV term
Evidence
References
eukaryotic initiation factor 4E binding
inferred from sequence or structural similarity
(Bernal and Kimbrell, 1998)
inferred from sequence or structural similarity with human EIF4EBP1
(Bernal and Kimbrell, 2000)
non-traceable author statement
(Bernal, 2000.3.10)
Biological Process
CV term
Evidence
References
defense response
non-traceable author statement
(Lemaitre, 2000.12.20)
immune response
non-traceable author statement
(Bernal, 2000.3.10)
negative regulation of cell size
traceable author statement
(Jacinto and Hall, 2003)
negative regulation of translational initiation
inferred from electronic annotation with InterPro:IPR008606
(FlyBase Curators et al., 2004-)
Cellular Component ( 0 terms)
hide Sequence Ontology: Class of Gene
gene
 
nuclear_gene
 
protein_coding_gene
 
hide Interactions & Pathways
hide Summary of Physical Interactions
protein-protein
Interacting group
Assay
References
Thor - CG2199
anti tag coimmunoprecipitation, peptide massfingerprinting
(Mintseris et al., 2009.11.23)
Thor - Rrp46
anti tag coimmunoprecipitation, peptide massfingerprinting
(Mintseris et al., 2009.11.23)
Thor - eIF-4E
two hybrid, anti bait coimmunoprecipitation, western blot
(Hernandez et al., 2012)
Thor - eIF4E-4
two hybrid
(Hernandez et al., 2012)
Thor - eIF4E-5
two hybrid
(Hernandez et al., 2012)
Thor - sick
anti tag coimmunoprecipitation, peptide massfingerprinting
(Mintseris et al., 2009.11.23)
hide Summary of Genetic Interactions
Interacts with
Please look at the allele data for full details of the genetic interactions
Thor allele
Gene
References
ThorLL.Scer\UAS
BacA\p35
(Miron et al., 2001)
ThorScer\UAS.cMa
Akt1
(Miron et al., 2001)
unspecified
Akt1
(Junger et al., 2003)
foxo
(Tettweiler et al., 2005, Tettweiler, 2005)
hide External Data
Linkouts
DroID - A comprehensive database of gene and protein interactions.
•
InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets.
•
hide Orthologs
hide OrthoDB Orthologs (50) - based on analysis using Dmel annotation version 5.41
OrthoDB Ortholog Groups
OrthoDB orthology group searches
(Waterhouse et al., 2011, Nucleic Acids Res. 39(Database issue): D283--D288)
Drosophila inclusive ortholog search
EOG6FFDNH
Dipteran inclusive ortholog search
EOG6WM54B
Insect inclusive ortholog search
EOG6ZW47X
Arthropod inclusive ortholog search
EOG6SQVDF
Metazoa inclusive ortholog search
EOG6T7N02
hideOrthologs in Drosophila Species (EOG6FFDNH)
Organism
Common Name
Gene
AAA Syntenic Ortholog
Multiple Dmel Genes in this Orthologous Group
Drosophila melanogaster
fruit fly 
 
 
Drosophila simulans
 
Y
 
Drosophila sechellia
 
Y
 
Drosophila erecta
 
Y
 
Drosophila yakuba
 
Y
 
Drosophila ananassae
 
Y
 
Drosophila pseudoobscura pseudoobscura
 
Y
 
Drosophila persimilis
 
Y
 
Drosophila willistoni
 
Y
 
Drosophila willistoni
 
 
 
Drosophila virilis
 
 
 
Drosophila virilis
 
Y
 
Drosophila mojavensis
 
 
 
Drosophila mojavensis
 
Y
 
Drosophila grimshawi
 
 
 
Drosophila grimshawi
 
Y
 
hideOrthologs in non-Drosophila Dipterans (EOG6WM54B)
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Aedes aegypti
Yellow fever mosquito 
 
Anopheles gambiae
Malaria mosquito 
 
Culex quinquefasciatus
Southern house mosquito 
 
hideOrthologs in non-Dipteran Insects (EOG6ZW47X)
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Apis mellifera
Western honey bee 
Amel\GB51712
 
Nasonia vitripennis
Parasitic wasp 
Nvit\Nasvi2EG002633
 
Acromyrmex echinatior
Panamanian leafcutter ant 
Aech\AECH11961
 
Atta cephalotes
Leafcutter ant 
Acep\ACEP23670
 
Camponotus floridanus
Florida carpenter ant 
Cflo\CFLO18320
 
Harpegnathos saltator
Jerdons jumping ant 
Hsal\HSAL20645
 
Linepithema humile
Argentine ant 
Lhum\LH24354
 
Pogonomyrmex barbatus
Red harvester ant 
Pbar\PB16575
 
Bombyx mori
Silkmoth 
 
Pediculus humanus
Human body louse 
 
Pediculus humanus
Human body louse 
 
Tribolium castaneum
Red flour beetle 
 
hideOrthologs in non-Insect Arthropods (EOG6SQVDF)
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Daphnia pulex
Water flea 
 
Ixodes scapularis
Deer tick 
 
hideOrthologs in non-Arthropod Metazoa (EOG6T7N02)
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strongylocentrotus purpuratus
Purple sea urchin 
 
Danio rerio
Zebrafish 
 
Danio rerio
Zebrafish 
 
Danio rerio
Zebrafish 
 
Danio rerio
Zebrafish 
 
Xenopus tropicalis
Western clawed frog 
 
Gallus gallus
Domestic chicken 
 
Gallus gallus
Domestic chicken 
 
Mus musculus
House mouse 
 
Mus musculus
House mouse 
 
Mus musculus
House mouse 
 
Rattus norvegicus
Norway rat 
 
Rattus norvegicus
Norway rat 
 
Rattus norvegicus
Norway rat 
 
Homo sapiens
Human 
 
Homo sapiens
Human 
 
Homo sapiens
Human 
 
hide Human Orthologs (3)
Gene
OMIM
HGNC
 
 
 
 
 
 
hideAAA Orthologs (11) based on analysis using Dmel annotation version 4.3
Organism
Gene
Drosophila simulans
Drosophila sechellia
Drosophila erecta
Drosophila yakuba
Drosophila ananassae
Drosophila pseudoobscura pseudoobscura
Drosophila persimilis
Drosophila willistoni
Drosophila virilis
Drosophila mojavensis
Drosophila grimshawi
hide Stocks & Reagents
hide Stocks Listed in FlyBase ( 15 )
Bloomington
9147
w*; P{UAS-Thor.wt}2
9559
y1 w*; Thor2
8651
w1118; P{UAS-p35.H}BH1; P{UAS-Thor.LL}s
8649
w*; wgSp-1/CyO; P{UAS-Thor.wt}3
9558
y1 w*; P{lacW}Thork13517
10681
y1 w67c23; P{lacW}Thork07736
11481
P{PZ}Thor06270 cn1/CyO; ry506
36815
y1 sc* v1; P{TRiP.GL01034}attP2
Kyoto
112399
w*; P{GawB}ThorNP0923 / CyO
VDRC
v100739
P{KK108272}VIE-260B
v35439
w1118; P{GD12533}v35439
v35440
w1118; P{GD12533}v35440
hide Genomic Clones ( 2 )

Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
hide cDNA Clones ( 74 )

Please Note
This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones
Other clones
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones
Other clones
hide RNAi & Array Information
Linkouts
DRSC - Results from RNAi screens.
•
GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents
•
hide Antibody Information
hide Other Information
hide Discoverer
hide Etymology
Ecol\lacZ reporter gene expression from the Thor enhancer trap insertion P{lacW}Thor[k13517] increases upon infection, and so the gene is named "Thor" after the Nordic legendary character that was often called upon to use his hammer to protect mankind from harm.
(Rodriguez et al., 1996)
hide Identification
hide Relationship to Other Genes
Source for database identity of
Source for database merge of
Source for merge of: Thor anon-WO0172774.158
(FlyBase, 1996-)
Source for merge of: Thor l(2)06270
(Mendes et al., 2009)
Additional comments
"l(2)06270" probably corresponds to "Thor"; the P{PZ} insertion in the "l(2)0627006270" allele maps 20bp upstream of the 5' end of the CT9265 transcript of "Thor".
(Misra, 2000.11.18, Misra, 2000.11.18)
Source for merge of Thor anon-WO0172774.158 was sequence comparison (date:051113).
(FlyBase, 1996-)
hide Other Comments
The Thor translational inhibitor is a relevant foxo target gene. Cellular stress may activate foxo and inhibit growth through the action of target genes such as Thor. Transcriptionally downregulated after 2h of insulin stimulation in Kc167 cells. Contains fkh response elements (FHREs) in the genomic upstream or intronic sequences.
(Junger et al., 2003)
Thor participates in host immune defence and connects a translational regulator with innate immunity.
(Bernal and Kimbrell, 2000)
The activity of eIF-4E is modulated by phosphorylation and by direct interaction with Thor.
(Lachance and Lasko, 1997)
Identified in a screen to find interactors with eIF-4E from a cDNA expression library. When bound to eIF-4E, Thor prevents the integration of eIF-4E into the translationally active eIF-4F complex. Thor may be involved in the translational regulation of specific mRNAs throughout development and adult fly life.
(Miron et al., 1997)
Cg25C is a member of the infection inducible enhancer detector strains.
(Rodriguez et al., 1996)
hide External Crossreferences & Linkouts
Sequence Crossreferences
RefSeq (Transcripts)
•
RefSeq (Proteins)
•
DDBJ / EMBL / GenBank
•
Entrez Gene - A searchable database of RefSeq genes.
•
UniProtKB/TrEMBL
•
Other Crossreferences
InterPro domains - A database of protein families, domains, and functional sites
•
Eukaryotic translation initiation factor 4E binding (IPR008606)
BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
•
Linkouts
DroID - A comprehensive database of gene and protein interactions.
•
DRSC - Results from RNAi screens.
•
FLIGHT - Cell culture data for RNAi and other high-throughput technologies
•
FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans
•
GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents
•
InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets.
•
modMine - Data generated by the modENCODE project.
•
hide Synonyms & Secondary IDs ( 38 )
Reported As
Symbol Synonym
4E-BP
(Teleman and Cohen, 2006, Colombani et al., 2005, Teleman et al., 2005, Hernandez et al., 2005, Jorgensen and Tyers, 2004, Pan et al., 2004, Nijhout, 2003, Jenkins and Lasko, 2004, Saucedo and Edgar, 2002, Oldham and Hafen, 2003, Adams et al., 2000, Lehner, 1999, Won et al., 1999, Miron et al., 1997, Lachance and Lasko, 1997, Hoshizaki and Gibbs, 2007, Ahrens et al., 2007, Fuss et al., 2006, Teleman et al., 2005, Yu et al., 2008, Hernandez et al., 2008, Hennig et al., 2006, Tadros et al., 2007, Harvey et al., 2008, Flatt et al., 2008, Lee et al., 2008, Imai et al., 2008, Lee et al., 2008, Teleman et al., 2008, Tain et al., 2009, Bolukbasi et al., 2012, Mesquita et al., 2010, Bauer et al., 2010, Söderberg et al., 2011, Alic et al., 2011, Wang et al., 2011, Wang et al., 2011, Poernbacher et al., 2012, Lee et al., 2010, Hernandez et al., 2012, King-Jones and Thummel, 2005, Xu et al., 2012, Grönke et al., 2010, Bryk et al., 2010, LaFever et al., 2010, Kim et al., 2010, Ottone et al., 2011, Gehrke et al., 2010, Lee et al., 2010, Alic et al., 2011, Wang et al., 2008, Lam et al., 2010, Demontis and Perrimon, 2010, Boyd et al., 2011, Liu et al., 2011, Stumpfe et al., 2010, Bjedov et al., 2010, Mahapatra et al., 2010, Duncan, 2008, Slack et al., 2011, Lee et al., 2012)
4EBP
(Lasko, 2000, Edgar, 2006, Wessells et al., 2007, Zid et al., 2007, Libert, 2007, Wang et al., 2008, Hietakangas and Cohen, 2007, Hall et al., 2007, Nuzhdin et al., 2009, Musselman et al., 2011, Hyun et al., 2009, McNeill et al., 2008, Francis et al., 2010, Wang et al., 2009, Cully et al., 2010, Birse et al., 2010, Okamoto et al., 2013, Wang et al., 2012)
4eBP
(Naylor and Tatar, 2007, Slack et al., 2010)
4e-bp
(Harvey et al., 2008)
4ebp
(Becker et al., 2010, Hsieh et al., 2010)
4E-BP1
(Findlay et al., 2005, McManus and Alessi, 2002, Findlay et al., 2007, Chakrabarti et al., 2012)
43-BP
(Hietakangas and Cohen, 2007)
153432_at
(Kristensen et al., 2005)
anon-WO0172774.158
 
BcDNA:HL08053
 
BcDNA.HL08053
(Tsang, 1999.3.2)
CG8846
(Pile et al., 2003, Pal et al., 2007, Keleman et al., 2009.8.5, Sun et al., 2010, Mosallanejad et al., 2010, Ni et al., 2011.7.19, Hernandez-Romano et al., 2008, Ellis and Carney, 2010)
CT8705
(Ceriani et al., 2002)
d4E-BP
(Tettweiler et al., 2005, Zhou et al., 2004, Junger et al., 2004, Junger et al., 2003, Jacinto and Hall, 2003, Miron et al., 2001, Kozma and Thomas, 2002, Miron et al., 2000, Miron et al., 1999, Bourouis et al., 2005, Marr et al., 2007, Lasko and Sonenberg, 2007, Song et al., 2010, Miron et al., 2003, Lee et al., 2008, Imai et al., 2008, Chang and Neufeld, 2009, Mendes et al., 2009, Agrawal et al., 2009, Zid et al., 2009, Tettweiler, 2005, Bülow et al., 2010, Curtis et al., 2007, Georgiev et al., 2010, Garrey et al., , Gehrke et al., 2010, Stumpfe et al., 2010, Kanao et al., 2010)
d4EBP
(Puig et al., 2003, Zid et al., 2007, Wittwer et al., 2005, Read et al., 2009, Luong et al., 2006, Delanoue et al., 2010)
d4e-bp
(Buch et al., 2008)
d4eBP
(Wessells et al., 2009)
d4E-BP1
(Jacinto and Hall, 2003)
Dm 4E-BP
(Miron et al., 1999)
dthor
(Wagner et al., 2009)
eIF4E-BP
(Ahmed and Duncan, 2004)
l(2)06270
(Mendes et al., 2009)
l(2)k07736
(Beaton, 2000.1.31, BDGP Project Members, 1994-1999, )
l(2)k13517
 
Phas1
(Kai et al., 2005, Coulier et al., 2000, Lemaitre, 2000.12.20, Misra, 2000.11.18, Spradling et al., 1999, )
pp20
(Won et al., 1999)
thor
(Wang et al., 2005, Seugnet et al., 2003, Lemaitre, 2000.12.20, Karpac et al., 2009, Buch et al., 2008, Hull-Thompson et al., 2009, Tohyama and Yamaguchi, 2010, Lee et al., 2010, Karpac et al., 2011, Wang et al., 2009, Fan et al., 2010, Sharma et al., 2011)
Thor
(Lasko and Sonenberg, 2007, Libert, 2007, Zhang et al., 2007, Bernal et al., 2004, Hall et al., 2007, Rynes et al., 2012, Alvarez-Ponce et al., 2009, Walkiewicz and Stern, 2009, Pezzulo et al., 2012, Roxstrom-Lindquist et al., 2004, Tain et al., 2009, Carpenter et al., 2009, Blanco et al., 2010, Sun et al., 2010, Bauer et al., 2010, Glatter et al., 2011, Lee et al., 2010, Mendes et al., 2009, Greene et al., 2005, Baker and Russell, 2009, Pedersen et al., 2008, Kapelnikov et al., 2008, Owusu-Ansah and Banerjee, 2009, Morozova et al., 2006, Fernández-Ayala et al., 2010, Becker et al., 2010, De Luca et al., 2010, Curtis et al., 2007, Nagoshi et al., 2010, LaFever et al., 2010, Ellis and Carney, 2010, Kim et al., 2010, Terashima and Bownes, 2005, Demontis and Perrimon, 2010, Mahapatra et al., 2010, Libert et al., 2008, Marcu et al., 2011, Tokusumi et al., 2012, Yampolsky et al., 2012, Okamoto et al., 2013, Zhang et al., 2012, Garelli et al., 2012, Wong et al., 2012, Paik et al., 2012, Ye et al., 2012)
Thor/EIF4EBP
(Zhang et al., 2012)
Name Synonym
eIF-4E-binding protein
(Miron et al., 1997, Lachance and Lasko, 1997, )
Eif4e-binding protein
(Wessells et al., 2009)
eif4e-binding protein 4EBP
(Wessells et al., 2007)
eukaryotic initiation factor 4E binding protein
(Hall et al., 2007)
eukaryotic initiation factor 4E-binding protein
(Wang et al., 2009)
eukaryotic translation initiation factor 4E-binding protein
(Lee et al., 2010)
eukaryotic translation initiation factor 4E binding protein
(LaFever et al., 2010)
insulin-stimulated eIF-4E binding protein
(Spradling et al., 1999)
lethal (2) 06270
 
Thor
(Pal et al., 2007, Hall et al., 2007, Roxstrom-Lindquist et al., 2004, Becker et al., 2010, Terashima and Bownes, 2005, Marcu et al., 2011)
Secondary FlyBase IDs
  • FBgn0010616
  • FBgn0017459
  • FBgn0020516
  • FBgn0022073
  • FBgn0027067
  • FBgn0046442
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Okamoto et al., 2013, Genes Dev. 27(1): 87--97
A secreted decoy of InR antagonizes insulin/IGF signaling to restrict body growth in Drosophila. [FBrf0220509]
Bolukbasi et al., 2012, Open Biol. 2(1): 110031
Drosophila poly suggests a novel role for the Elongator complex in insulin receptor-target of rapamycin signalling. [FBrf0218466]
Chakrabarti et al., 2012, Cell Host Microbe 12(1): 60--70
Infection-induced host translational blockage inhibits immune responses and epithelial renewal in the Drosophila gut. [FBrf0218984]
Dragojlovic-Munther and Martinez-Agosto, 2012, Development 139(20): 3752--3763
Multifaceted roles of PTEN and TSC orchestrate growth and differentiation of Drosophila blood progenitors. [FBrf0219482]
Fuda et al., 2012, Mol. Cell. Biol. 32(17): 3428--3437
Fcp1 Dephosphorylation of the RNA Polymerase II C-Terminal Domain Is Required for Efficient Transcription of Heat Shock Genes. [FBrf0219151]
Garelli et al., 2012, Science 336(6081): 579--582
Imaginal discs secrete insulin-like peptide 8 to mediate plasticity of growth and maturation. [FBrf0218214]
Hernandez et al., 2012, Development 139(17): 3211--3220
Eukaryotic initiation factor 4E-3 is essential for meiotic chromosome segregation, cytokinesis and male fertility in Drosophila. [FBrf0219080]
Koh et al., 2012, J. Biol. Chem. 287(16): 12750--12758
Silent Information Regulator 2 (Sir2) and Forkhead Box O (FOXO) Complement Mitochondrial Dysfunction and Dopaminergic Neuron Loss in Drosophila PTEN-induced Kinase 1 (PINK1) Null Mutant. [FBrf0218041]
Lee et al., 2012, Oxid. Med. Cell. Longev. 2012: 854502
Overexpression of Fatty-Acid-β-Oxidation-Related Genes Extends the Lifespan of Drosophila melanogaster. [FBrf0219491]
Nakagawa-Yagi et al., 2012, BMC Complement. Altern. Med. 12: 101
Pharmacological modulation of histone demethylase activity by a small molecule isolated from subcritical water extracts of Sasa senanensis leaves prolongs the lifespan of Drosophila melanogaster. [FBrf0220678]
Paik et al., 2012, Mech. Ageing Dev. 133(5): 234--245
Misexpression screen delineates novel genes controlling Drosophila lifespan. [FBrf0218389]
Pezzulo et al., 2012, PLoS ONE 7(8): e43777
Expression of Human Paraoxonase 1 Decreases Superoxide Levels and Alters Bacterial Colonization in the Gut of Drosophila melanogaster. [FBrf0219363]
Poernbacher et al., 2012, Curr. Biol. 22(5): 389--396
Drosophila Pez acts in hippo signaling to restrict intestinal stem cell proliferation. [FBrf0217766]
Rynes et al., 2012, Mol. Cell. Biol. 32(19): 3949--3962
Activating transcription factor 3 regulates immune and metabolic homeostasis. [FBrf0219385]
Tokusumi et al., 2012, PLoS ONE 7(7): e41604
Gene regulatory networks controlling hematopoietic progenitor niche cell production and differentiation in the Drosophila lymph gland. [FBrf0219204]
Vesala et al., 2012, Insect Mol. Biol. 21(1): 107--118
Cold tolerance and cold-induced modulation of gene expression in two Drosophila virilis group species with different distributions. [FBrf0217233]
Wang et al., 2012, Sci. Rep. 2: 563
Akt signaling-associated metabolic effects of dietary gold nanoparticles in Drosophila. [FBrf0219113]
Wong et al., 2012, Curr. Biol. 22(17): 1616--1621
Drosophila TRPML Is Required for TORC1 Activation. [FBrf0219457]
Xu et al., 2012, PLoS Genet. 8(1): e1002478
Insulin Signaling Regulates Fatty Acid Catabolism at the Level of CoA Activation. [FBrf0217254]
Yampolsky et al., 2012, Mol. Ecol. 21(17): 4287--4299
Evolution of gene expression and expression plasticity in long-term experimental populations of Drosophila melanogaster maintained under constant and variable ethanol stress. [FBrf0219282]
Ye et al., 2012, Dev. Biol. 369(1): 115--123
Akt is negatively regulated by Hippo signaling for growth inhibition in Drosophila. [FBrf0219022]
Zhang et al., 2012, Cell Death Dis. 3: 266
The EIF4EBP3 translational repressor is a marker of CDC73 tumor suppressor haploinsufficiency in a parathyroid cancer syndrome. [FBrf0217356]
Alic et al., 2011, Mol. Syst. Biol. 7: 502
Genome-wide dFOXO targets and topology of the transcriptomic response to stress and insulin signalling. [FBrf0214014]
Alic et al., 2011, Aging Cell 10(1): 137--147
Lifespan extension by increased expression of the Drosophila homologue of the IGFBP7 tumour suppressor. [FBrf0212768]
Bono et al., 2011, Proc. Natl. Acad. Sci. U.S.A. 108(19): 7878--7883
Postmating transcriptional changes in reproductive tracts of con- and heterospecifically mated Drosophila mojavensis females. [FBrf0213680]
Boyd et al., 2011, Free Radical Biol. Med. 50(11): 1669--1678
Nectarine promotes longevity in Drosophila melanogaster. [FBrf0213612]
Cheng et al., 2011, Cell 146(3): 435--447
Anaplastic Lymphoma Kinase Spares Organ Growth during Nutrient Restriction in Drosophila. [FBrf0214599]
Glatter et al., 2011, Mol. Syst. Biol. 7: 547
Modularity and hormone sensitivity of the Drosophila melanogaster insulin receptor/target of rapamycin interaction proteome. [FBrf0216604]
Karpac et al., 2011, Dev. Cell 20(6): 841--854
Dynamic coordination of innate immune signaling and insulin signaling regulates systemic responses to localized DNA damage. [FBrf0213873]
Liu et al., 2011, J. Genet. Genomics 38(6): 225--234
Drosophila sbo regulates lifespan through its function in the synthesis of coenzyme Q in vivo. [FBrf0214012]
Marcu et al., 2011, PLoS ONE 6(1): e15361
Innate Immune Responses of Drosophila melanogaster Are Altered by Spaceflight. [FBrf0212851]
Morozova et al., 2011, Genetics 187(4): 1193--1205
Transcriptional networks for alcohol sensitivity in Drosophila melanogaster. [FBrf0214377]
Musselman et al., 2011, Dis. Model Mech. 4(6): 842--849
A high-sugar diet produces obesity and insulin resistance in wild-type Drosophila. [FBrf0216626]
Noyes et al., 2011, G3 (Bethesda) 1(6): 471--478
Modulation of the activity of a polycomb-group response element in Drosophila by a mutation in the transcriptional activator woc. [FBrf0217652]
Ottone et al., 2011, Gene 470(1-2): 12--19
Diminution of eIF4E activity suppresses parkin mutant phenotypes. [FBrf0212264]
Sharma et al., 2011, Chemosphere 82(3): 370--376
Transcriptome analysis provides insights for understanding the adverse effects of endosulfan in Drosophila melanogaster. [FBrf0212610]
Sinenko et al., 2011, EMBO Rep. 13(1): 83--89
Oxidative stress in the haematopoietic niche regulates the cellular immune response in Drosophila. [FBrf0217071]
Slack et al., 2011, Aging Cell 10(5): 735--748
dFOXO-independent effects of reduced insulin-like signaling in Drosophila. [FBrf0215229]
Söderberg et al., 2011, PLoS ONE 6(5): e19866
Insulin Production and Signaling in Renal Tubules of Drosophila Is under Control of Tachykinin-Related Peptide and Regulates Stress Resistance. [FBrf0213657]
Wang et al., 2011, Cell Cycle 10(16): 2628--2634
Regulation of adult stem cell behavior by nutrient signaling. [FBrf0214811]
Wang et al., 2011, Cell 145(4): 596--606
A hormone-dependent module regulating energy balance. [FBrf0213699]
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