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Gene Dmel\wb

General Information
Symbol	Dmel\wb	Species	D. melanogaster
Name	wing blister	Annotation symbol	CG42677
Feature type	protein_coding_gene	FlyBase ID	FBgn0261563
Gene Model Status	Current	Stock availability	28 publicly available
Also Known As	l(2)br1, CG15288, BG:DS03792.2, l(2)34Fb, A1, BG:DS03792.1
Genomic Location
Chromosome (arm)	2L	Recombination map
Cytogenetic map	35A3-35A4	Sequence location	2L:14,263,027..14,328,262 [+]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents Beta	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene wing blister is referred to in FlyBase by the symbol Dmel\wb (CG42677, FBgn0261563). It is a protein_coding_gene from Drosophila melanogaster. An electronic pipeline based on InterPro domains suggests that it has the molecular function: receptor binding. There is experimental evidence that it is involved in the biological process: digestive tract mesoderm development; gonad development; imaginal disc-derived wing morphogenesis. 83 alleles are reported. The phenotypes of these alleles are annotated with: embryonic/larval dorsal vessel; gastrula embryo; embryonic/larval pericardial cell; ventral oblique muscle; embryonic/larval dorsal trunk; wing; embryonic/larval somatic muscle. It has 6 annotated transcripts and 6 annotated polypeptides. Protein features are: Concanavalin A-like lectin/glucanase, subgroup; Concanavalin A-like lectin/glucanases superfamily; EGF-like, conserved site; EGF-like, laminin; Laminin B type IV; Laminin G domain; Laminin I; Laminin II; Laminin, N-terminal. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of very low expression. Peak expression observed within 00-18 hour embryonic stages. Summary of FlyAtlas Anatomical Expression Data: Two or more Affy2 ProbeSets identify exons of this gene. This is a summary of the tissue expression peaks exhibited in at least one of these ProbeSets. Expression at moderate levels in the following post-embryonic organs or tissues: adult heart, adult salivary gland, adult male accessory gland. Gene sequence location is 2L:14263027..14328262.
User Contributed Data
	Beta version, feedback welcome
Phenotypic Description from the Red Book (Lindsley & Zimm 1992)
Gene/Allele symbols may differ from current usage	wb: wing blister Most of the mutants are characterized by homo- or hemizygous lethality, but a visible phenotype has also been reported. O'Donnell et al., 1977, describe a bent-down-wing phenotype occurring when one of their lethals is crossed to other lethals in the same complementation group and the same phenotype when three of their lethals are crossed to deletions for the locus. Woodruff and Ashburner, 1979, describe the viable and fertile wing blister phenotype (a roughly circular area around the crossveins of the wing, forming a blister which often collapses soon after eclosion, distorting the wing blade). The allele showing this phenotype (wb1) is viable and fertile in homozygotes and hemizygotes as well as in heteroallelic combinations with lethal alleles.
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 35A3-35A4   Limits computationally determined from genome sequence between P{lacW}l(2)34Fak00811&P{PZ}wb09437 and P{EP}elBEP2039&P{PZ}osprJ571
Experimentally Determined Cytological Location
Cytogenetic map Notes References 35A1-35A2     (Martin, 1999.3.16) 34F1-34F4   (determined by in situ hybridisation) 35A1--2 (determined by in situ hybridisation)   (Ashburner et al., 1999) 35A1-35A2   (determined by in situ hybridisation)   (Spradling et al., 1999) 35A1-35A2     (BDGP Project Members, 1994-1999)
Experimentally Determined Recombination Data
Location	2-50 (Ashburner et al., 1980) 2-49.9 (Lindsley and Zimm, 1992)
Left of (cM)	Pgant35A (Woodruff and Ashburner, 1979) elB elA (Ashburner et al., 1980) Adh (Woodruff and Ashburner, 1979, Lindsley and Zimm, 1992)
Right of (cM)
Notes	Maps 0.1 cM to the left of Tp(2;2)Sco. (Woodruff and Ashburner, 1979)
Gene Model & Products
Please see the GBrowse view of Dmel\wb for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
	Gene model reviewed during 5.42 Gene model reviewed during 5.51 Gene merge based on protein alignment (BLASTX) and RNAseq data.
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) wb-RB FBtr0302731  NM_165086   11333   3375 wb-RC FBtr0302732  NM_001201877   8975   2567 wb-RD FBtr0302733  NM_001201878   9057   2567 wb-RE FBtr0302734  NM_001201879   9183   2567 wb-RF FBtr0302735  NM_001201880   8996   2567 wb-RG FBtr0305063  NM_057442   10270   3001
Additional Transcript Data & Comments
Reported size (kB)	11 (northern blot) (Martin et al., 1999)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein wb-PB   FBpp0291871   374.7   3375   6.79     NP_723870   AAN10875 wb-PC   FBpp0291872   287.7   2567   8.40     NP_001188806   ADV37056 wb-PD   FBpp0291873   287.7   2567   8.40     NP_001188807   ADV37057 wb-PE   FBpp0291874   287.7   2567   8.40     NP_001188808   ADV37058 wb-PF   FBpp0291875   287.7   2567   8.40     NP_001188809   ADV37059 wb-PG   FBpp0293600   332.7   3001   6.61     NP_476790   AAF53381
Additional Polypeptide Data & Comments
Reported size (kDa)	3367 (aa); 360 (kD observed); 374 (kD predicted) (Martin et al., 1999)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Laminin B type IV (IPR000034) Laminin G domain (IPR001791) EGF-like, laminin (IPR002049) Laminin, N-terminal (IPR008211) Concanavalin A-like lectin/glucanases superfamily (IPR008985) Laminin I (IPR009254) Laminin II (IPR010307) EGF-like, conserved site (IPR013032) Concanavalin A-like lectin/glucanase, subgroup (IPR013320)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA140696   AA140697   AA141179   AA141691   AA141692   AE014134 AAF53381   AE014134 AAN10875   AC092248   AE014134 ADV37056   AE014134 ADV37057   AE014134 ADV37058   AE014134 ADV37059   AE003409 AAF44861   AE003409 AAF44862   AF135118 AAD31714   AQ025808   AQ026114   AQ026440   AQ026443   BH011482   BI568280   BP554790   BP556354   BP556355   BP558124   BP558125   BP559354   BP559355   BT025150   BT025926   BT025928   BT120062   CL844479   CO283939   CO316030   CO330019   CO338233   CZ467753   CZ468884   CZ472234   CZ473412   CZ473479   CZ477975   CZ478020   CZ480408   CZ486441   CZ486442   CZ486508   CZ486509   CZ488951   CZ488952   EC203963   EC204610   EC250757   EC263474   EL871879   EL874807   EL882842   G00417
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL	Q8IP51 Q9XZC9 Q7KT92
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
in situ Stage Tissue/Position (including subcellular localization) Reference embryonic stage 1 -- 4   organism | ubiquitous & uniform   (Martin et al., 1999) embryonic stage 13 -- 17   visceral mesoderm   (Martin et al., 1999) northern blot Stage Tissue/Position (including subcellular localization) Reference embryonic stage | early   organism | ubiquitous   (Martin et al., 1999) embryonic stage -- adult stage     (Martin et al., 1999) embryonic stage 9 -- 11   organism | ubiquitous   (Martin et al., 1999) embryonic stage 13 -- 17   muscle attachment site | vicinity of   (Martin et al., 1999) embryonic stage 14   alary cell   (Martin et al., 1999) adult stage & oogenesis   oocyte   (Martin et al., 1999) nurse cell   (Martin et al., 1999)
Additional Descriptive Data
	11kb wb trancripts are first detected in early stages of embryogenesis and peak in 6-12hr embryos on northern blots. Transcripts are barely detectable in third instar larvae and increase again in pupal stages. A weak 10.5kb is also detected in later embryos. wb transcripts are first detected by in situ hybridization during oogenesis in nurse cells and growing oocytes. Transcripts are uniformly distributed in cleavage stage embryos and are enriched in cells of the trunk region in blastoderm embryos. During germ band extension, wb tr nscripts are uniformly distributed. After germ band retraction, transcripts accumulate in the visceral mesoderm, near muscle attachment sites, and in cardiac cells. (Martin et al., 1999)
Marker for
Subcellular Localization
CV Term
Polypeptide Expression
immunolocalization Stage Tissue/Position (including subcellular localization) Reference embryonic stage 10   mesectoderm   (Martin et al., 1999) embryonic stage 12 -- 17   visceral mesoderm   (Martin et al., 1999) embryonic stage 14   muscle attachment site   (Martin et al., 1999) embryonic stage 15 -- 17   ventral nerve cord | dorsal   (Martin et al., 1999) third instar larval stage   wing disc | restricted   (Martin et al., 1999) wing pouch | restricted   (Martin et al., 1999) Comment:in a spot pattern
Additional Descriptive Data
	wb protein is first observed in stage 10 embryos as a weak diffusive stripe between the ectoderm and the mesoderm. During germ band retraction, the protein is localized diffusely in the visceral mesoderm. At stage 14, strong staining is observed in the basement membranes that surround the digestive system and at muscle attachment sites. In later stages, staining is observed in dorsal structures along the ventral nerve cord and in basement membranes around the digestive system. wb protein is also observed in developing wing imaginal d scs in a spot pattern on the presumptive wing dorsal and ventral region. (Martin et al., 1999)
Marker for
Subcellular Localization (GO Cellular Component)
CV term Evidence References
basal lamina inferred from direct assay (Baumgartner and Martin, 1997)
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools
Reference	See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes.
FlyAtlas Anatomy Microarray
FlyAtlas Anatomical Expression Data (FlyAtlas-RNA.adult) (FlyAtlas-RNA.larva)    Styles Linear Logarithmic Heatmap Back-to-back    Scales gene max expression Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Two or more Affy2 ProbeSets identify exons of this gene. This is a summary of the tissue expression peaks exhibited in at least one of these ProbeSets. Expression at moderate levels in the following post-embryonic organs or tissues: adult heart, adult salivary gland, adult male accessory gland. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (>999.999) Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
modENCODE Anatomy RNA-Seq
modENCODE Tissue Expression Data (modENCODE_mRNA-Seq_tissues)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    3 central nervous system, larvae L3    3 central nervous system, pupae P8    4 head, virgin 1-day female    1 head, virgin 4-day female    0 head, virgin 20-day female    1 head, mated 1-day female    1 head, mated 4-day female    0 head, mated 20-day female    0 head, mated 1-day male    1 head, mated 4-day male    1 head, mated 20-day male    1 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    0 digestive system, larvae L3 wandering    1 digestive system, 1-day adult    1 digestive system, 4-day adult    1 digestive system, 20-day adult    1 fat body, larvae L3 wandering    0 fat body, white prepupae    1 fat body, pupae P8    3 carcass, larvae L3 wandering    2 carcass, 1-day adult    1 carcass, 4-day adult    1 carcass, 20-day adult    1 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    1 accessory gland, mated 4-day male    2 Expression Level Scale  Very low   Low   Moderate  Linear, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering    3 central nervous system, larvae L3    3 central nervous system, pupae P8    4 head, virgin 1-day female    1 head, virgin 4-day female    0 head, virgin 20-day female    1 head, mated 1-day female    1 head, mated 4-day female    0 head, mated 20-day female    0 head, mated 1-day male    1 head, mated 4-day male    1 head, mated 20-day male    1 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    0 digestive system, larvae L3 wandering    1 digestive system, 1-day adult    1 digestive system, 4-day adult    1 digestive system, 20-day adult    1 fat body, larvae L3 wandering    0 fat body, white prepupae    1 fat body, pupae P8    3 carcass, larvae L3 wandering    2 carcass, 1-day adult    1 carcass, 4-day adult    1 carcass, 20-day adult    1 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    1 accessory gland, mated 4-day male    2 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    3 central nervous system, larvae L3    3 central nervous system, pupae P8    4 head, virgin 1-day female    1 head, virgin 4-day female    0 head, virgin 20-day female    1 head, mated 1-day female    1 head, mated 4-day female    0 head, mated 20-day female    0 head, mated 1-day male    1 head, mated 4-day male    1 head, mated 20-day male    1 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    0 digestive system, larvae L3 wandering    1 digestive system, 1-day adult    1 digestive system, 4-day adult    1 digestive system, 20-day adult    1 fat body, larvae L3 wandering    0 fat body, white prepupae    1 fat body, pupae P8    3 carcass, larvae L3 wandering    2 carcass, 1-day adult    1 carcass, 4-day adult    1 carcass, 20-day adult    1 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    1 accessory gland, mated 4-day male    2 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    3 central nervous system, larvae L3    3 central nervous system, pupae P8    4 head, virgin 1-day female    1 head, virgin 4-day female    0 head, virgin 20-day female    1 head, mated 1-day female    1 head, mated 4-day female    0 head, mated 20-day female    0 head, mated 1-day male    1 head, mated 4-day male    1 head, mated 20-day male    1 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    0 digestive system, larvae L3 wandering    1 digestive system, 1-day adult    1 digestive system, 4-day adult    1 digestive system, 20-day adult    1 fat body, larvae L3 wandering    0 fat body, white prepupae    1 fat body, pupae P8    3 carcass, larvae L3 wandering    2 carcass, 1-day adult    1 carcass, 4-day adult    1 carcass, 20-day adult    1 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    1 accessory gland, mated 4-day male    2 Expression Level Scale  Extremely high  log, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    3 central nervous system, larvae L3    3 central nervous system, pupae P8    4 head, virgin 1-day female    1 head, virgin 4-day female    0 head, virgin 20-day female    1 head, mated 1-day female    1 head, mated 4-day female    0 head, mated 20-day female    0 head, mated 1-day male    1 head, mated 4-day male    1 head, mated 20-day male    1 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    0 digestive system, larvae L3 wandering    1 digestive system, 1-day adult    1 digestive system, 4-day adult    1 digestive system, 20-day adult    1 fat body, larvae L3 wandering    0 fat body, white prepupae    1 fat body, pupae P8    3 carcass, larvae L3 wandering    2 carcass, 1-day adult    1 carcass, 4-day adult    1 carcass, 20-day adult    1 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    1 accessory gland, mated 4-day male    2 Expression Level Scale  Very low   Low   Moderate  log, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering    3 central nervous system, larvae L3    3 central nervous system, pupae P8    4 head, virgin 1-day female    1 head, virgin 4-day female    0 head, virgin 20-day female    1 head, mated 1-day female    1 head, mated 4-day female    0 head, mated 20-day female    0 head, mated 1-day male    1 head, mated 4-day male    1 head, mated 20-day male    1 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    0 digestive system, larvae L3 wandering    1 digestive system, 1-day adult    1 digestive system, 4-day adult    1 digestive system, 20-day adult    1 fat body, larvae L3 wandering    0 fat body, white prepupae    1 fat body, pupae P8    3 carcass, larvae L3 wandering    2 carcass, 1-day adult    1 carcass, 4-day adult    1 carcass, 20-day adult    1 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    1 accessory gland, mated 4-day male    2 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    3 central nervous system, larvae L3    3 central nervous system, pupae P8    4 head, virgin 1-day female    1 head, virgin 4-day female    0 head, virgin 20-day female    1 head, mated 1-day female    1 head, mated 4-day female    0 head, mated 20-day female    0 head, mated 1-day male    1 head, mated 4-day male    1 head, mated 20-day male    1 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    0 digestive system, larvae L3 wandering    1 digestive system, 1-day adult    1 digestive system, 4-day adult    1 digestive system, 20-day adult    1 fat body, larvae L3 wandering    0 fat body, white prepupae    1 fat body, pupae P8    3 carcass, larvae L3 wandering    2 carcass, 1-day adult    1 carcass, 4-day adult    1 carcass, 20-day adult    1 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    1 accessory gland, mated 4-day male    2 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    3 central nervous system, larvae L3    3 central nervous system, pupae P8    4 head, virgin 1-day female    1 head, virgin 4-day female    0 head, virgin 20-day female    1 head, mated 1-day female    1 head, mated 4-day female    0 head, mated 20-day female    0 head, mated 1-day male    1 head, mated 4-day male    1 head, mated 20-day male    1 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    0 digestive system, larvae L3 wandering    1 digestive system, 1-day adult    1 digestive system, 4-day adult    1 digestive system, 20-day adult    1 fat body, larvae L3 wandering    0 fat body, white prepupae    1 fat body, pupae P8    3 carcass, larvae L3 wandering    2 carcass, 1-day adult    1 carcass, 4-day adult    1 carcass, 20-day adult    1 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    1 accessory gland, mated 4-day male    2 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Tissue   Expression Level imaginal disc, larvae L3 wandering     central nervous system, larvae L3     central nervous system, pupae P8     head, virgin 1-day female     head, virgin 4-day female     head, virgin 20-day female     head, mated 1-day female     head, mated 4-day female     head, mated 20-day female     head, mated 1-day male     head, mated 4-day male     head, mated 20-day male     salivary gland, larvae L3 wandering     salivary gland, white prepupae     digestive system, larvae L3 wandering     digestive system, 1-day adult     digestive system, 4-day adult     digestive system, 20-day adult     fat body, larvae L3 wandering     fat body, white prepupae     fat body, pupae P8     carcass, larvae L3 wandering     carcass, 1-day adult     carcass, 4-day adult     carcass, 20-day adult     ovary, virgin 4-day female     ovary, mated 4-day female     testis, mated 4-day male     accessory gland, mated 4-day male
modENCODE Development RNA-Seq
modENCODE Temporal Expression Data (modENCODE_mRNA-Seq_U)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of very low expression. Peak expression observed within 00-18 hour embryonic stages. [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    6 embryo 04-06hr    19 embryo 06-08hr    21 embryo 08-10hr    20 embryo 10-12hr    16 embryo 12-14hr    19 embryo 14-16hr    19 embryo 16-18hr    13 embryo 18-20hr    6 embryo 20-22hr    2 embryo 22-24hr    2 larva L1    1 larva L2    1 larva L3 12hr old    1 larva L3 puffstage 1-2    1 larva L3 puffstage 3-6    2 larva L3 puffstage 7-9    4 white prepupae new    5 white prepupae 12hr    9 white prepupae 24hr    15 pupae 2d postWPP    14 pupae 3d postWPP    9 pupae 4d postWPP    3 adult male 01day    2 adult male 05day    2 adult male 30day    2 adult female 01day    2 adult female 05day    1 adult female 30day    1 Expression Level Scale  Very low   Low   Moderate  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    6 embryo 04-06hr    19 embryo 06-08hr    21 embryo 08-10hr    20 embryo 10-12hr    16 embryo 12-14hr    19 embryo 14-16hr    19 embryo 16-18hr    13 embryo 18-20hr    6 embryo 20-22hr    2 embryo 22-24hr    2 larva L1    1 larva L2    1 larva L3 12hr old    1 larva L3 puffstage 1-2    1 larva L3 puffstage 3-6    2 larva L3 puffstage 7-9    4 white prepupae new    5 white prepupae 12hr    9 white prepupae 24hr    15 pupae 2d postWPP    14 pupae 3d postWPP    9 pupae 4d postWPP    3 adult male 01day    2 adult male 05day    2 adult male 30day    2 adult female 01day    2 adult female 05day    1 adult female 30day    1 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    6 embryo 04-06hr    19 embryo 06-08hr    21 embryo 08-10hr    20 embryo 10-12hr    16 embryo 12-14hr    19 embryo 14-16hr    19 embryo 16-18hr    13 embryo 18-20hr    6 embryo 20-22hr    2 embryo 22-24hr    2 larva L1    1 larva L2    1 larva L3 12hr old    1 larva L3 puffstage 1-2    1 larva L3 puffstage 3-6    2 larva L3 puffstage 7-9    4 white prepupae new    5 white prepupae 12hr    9 white prepupae 24hr    15 pupae 2d postWPP    14 pupae 3d postWPP    9 pupae 4d postWPP    3 adult male 01day    2 adult male 05day    2 adult male 30day    2 adult female 01day    2 adult female 05day    1 adult female 30day    1 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    6 embryo 04-06hr    19 embryo 06-08hr    21 embryo 08-10hr    20 embryo 10-12hr    16 embryo 12-14hr    19 embryo 14-16hr    19 embryo 16-18hr    13 embryo 18-20hr    6 embryo 20-22hr    2 embryo 22-24hr    2 larva L1    1 larva L2    1 larva L3 12hr old    1 larva L3 puffstage 1-2    1 larva L3 puffstage 3-6    2 larva L3 puffstage 7-9    4 white prepupae new    5 white prepupae 12hr    9 white prepupae 24hr    15 pupae 2d postWPP    14 pupae 3d postWPP    9 pupae 4d postWPP    3 adult male 01day    2 adult male 05day    2 adult male 30day    2 adult female 01day    2 adult female 05day    1 adult female 30day    1 Expression Level Scale  Extremely high  log, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    6 embryo 04-06hr    19 embryo 06-08hr    21 embryo 08-10hr    20 embryo 10-12hr    16 embryo 12-14hr    19 embryo 14-16hr    19 embryo 16-18hr    13 embryo 18-20hr    6 embryo 20-22hr    2 embryo 22-24hr    2 larva L1    1 larva L2    1 larva L3 12hr old    1 larva L3 puffstage 1-2    1 larva L3 puffstage 3-6    2 larva L3 puffstage 7-9    4 white prepupae new    5 white prepupae 12hr    9 white prepupae 24hr    15 pupae 2d postWPP    14 pupae 3d postWPP    9 pupae 4d postWPP    3 adult male 01day    2 adult male 05day    2 adult male 30day    2 adult female 01day    2 adult female 05day    1 adult female 30day    1 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    6 embryo 04-06hr    19 embryo 06-08hr    21 embryo 08-10hr    20 embryo 10-12hr    16 embryo 12-14hr    19 embryo 14-16hr    19 embryo 16-18hr    13 embryo 18-20hr    6 embryo 20-22hr    2 embryo 22-24hr    2 larva L1    1 larva L2    1 larva L3 12hr old    1 larva L3 puffstage 1-2    1 larva L3 puffstage 3-6    2 larva L3 puffstage 7-9    4 white prepupae new    5 white prepupae 12hr    9 white prepupae 24hr    15 pupae 2d postWPP    14 pupae 3d postWPP    9 pupae 4d postWPP    3 adult male 01day    2 adult male 05day    2 adult male 30day    2 adult female 01day    2 adult female 05day    1 adult female 30day    1 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    6 embryo 04-06hr    19 embryo 06-08hr    21 embryo 08-10hr    20 embryo 10-12hr    16 embryo 12-14hr    19 embryo 14-16hr    19 embryo 16-18hr    13 embryo 18-20hr    6 embryo 20-22hr    2 embryo 22-24hr    2 larva L1    1 larva L2    1 larva L3 12hr old    1 larva L3 puffstage 1-2    1 larva L3 puffstage 3-6    2 larva L3 puffstage 7-9    4 white prepupae new    5 white prepupae 12hr    9 white prepupae 24hr    15 pupae 2d postWPP    14 pupae 3d postWPP    9 pupae 4d postWPP    3 adult male 01day    2 adult male 05day    2 adult male 30day    2 adult female 01day    2 adult female 05day    1 adult female 30day    1 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    6 embryo 04-06hr    19 embryo 06-08hr    21 embryo 08-10hr    20 embryo 10-12hr    16 embryo 12-14hr    19 embryo 14-16hr    19 embryo 16-18hr    13 embryo 18-20hr    6 embryo 20-22hr    2 embryo 22-24hr    2 larva L1    1 larva L2    1 larva L3 12hr old    1 larva L3 puffstage 1-2    1 larva L3 puffstage 3-6    2 larva L3 puffstage 7-9    4 white prepupae new    5 white prepupae 12hr    9 white prepupae 24hr    15 pupae 2d postWPP    14 pupae 3d postWPP    9 pupae 4d postWPP    3 adult male 01day    2 adult male 05day    2 adult male 30day    2 adult female 01day    2 adult female 05day    1 adult female 30day    1 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     modENCODE Temporal Expression Data (Graveley et al., 2011)
modENCODE Cell Lines RNA-Seq
modENCODE Cell Line Expression Data (modENCODE_mRNA-Seq_cell.A) (modENCODE_mRNA-Seq_cell.B)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    2 Schneider line 2 Sg4    2 embryonic 1182-4H    5 embryonic GM2    0 embryonic Kc167    0 embryonic S1    1 embryonic S3    0 leg disc CME L1    2 wing disc CME-W2    0 wing disc ML-DmD8    8 wing disc ML-DmD9    5 wing disc ML-DmD16-c3    8 wing disc ML-DmD21    0 wing disc ML-DmD32    5 haltere disc ML-DmD17-c3    5 eye-antennal disc ML-DmD11    2 antennal disc ML-DmD20-c5    2 mixed discs ML-DmD4-c1    2 CNS ML-DmBG1-c1    5 CNS ML-DmBG2-c2    5 tumorous blood cells mbn2    3 ovary fGS/OSS    0 ovary OSC    0 ovary OSS    3 Expression Level Scale  Very low   Low   Moderate  Linear, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+    2 Schneider line 2 Sg4    2 embryonic 1182-4H    5 embryonic GM2    0 embryonic Kc167    0 embryonic S1    1 embryonic S3    0 leg disc CME L1    2 wing disc CME-W2    0 wing disc ML-DmD8    8 wing disc ML-DmD9    5 wing disc ML-DmD16-c3    8 wing disc ML-DmD21    0 wing disc ML-DmD32    5 haltere disc ML-DmD17-c3    5 eye-antennal disc ML-DmD11    2 antennal disc ML-DmD20-c5    2 mixed discs ML-DmD4-c1    2 CNS ML-DmBG1-c1    5 CNS ML-DmBG2-c2    5 tumorous blood cells mbn2    3 ovary fGS/OSS    0 ovary OSC    0 ovary OSS    3 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    2 Schneider line 2 Sg4    2 embryonic 1182-4H    5 embryonic GM2    0 embryonic Kc167    0 embryonic S1    1 embryonic S3    0 leg disc CME L1    2 wing disc CME-W2    0 wing disc ML-DmD8    8 wing disc ML-DmD9    5 wing disc ML-DmD16-c3    8 wing disc ML-DmD21    0 wing disc ML-DmD32    5 haltere disc ML-DmD17-c3    5 eye-antennal disc ML-DmD11    2 antennal disc ML-DmD20-c5    2 mixed discs ML-DmD4-c1    2 CNS ML-DmBG1-c1    5 CNS ML-DmBG2-c2    5 tumorous blood cells mbn2    3 ovary fGS/OSS    0 ovary OSC    0 ovary OSS    3 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    2 Schneider line 2 Sg4    2 embryonic 1182-4H    5 embryonic GM2    0 embryonic Kc167    0 embryonic S1    1 embryonic S3    0 leg disc CME L1    2 wing disc CME-W2    0 wing disc ML-DmD8    8 wing disc ML-DmD9    5 wing disc ML-DmD16-c3    8 wing disc ML-DmD21    0 wing disc ML-DmD32    5 haltere disc ML-DmD17-c3    5 eye-antennal disc ML-DmD11    2 antennal disc ML-DmD20-c5    2 mixed discs ML-DmD4-c1    2 CNS ML-DmBG1-c1    5 CNS ML-DmBG2-c2    5 tumorous blood cells mbn2    3 ovary fGS/OSS    0 ovary OSC    0 ovary OSS    3 Expression Level Scale  Extremely high  log, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    2 Schneider line 2 Sg4    2 embryonic 1182-4H    5 embryonic GM2    0 embryonic Kc167    0 embryonic S1    1 embryonic S3    0 leg disc CME L1    2 wing disc CME-W2    0 wing disc ML-DmD8    8 wing disc ML-DmD9    5 wing disc ML-DmD16-c3    8 wing disc ML-DmD21    0 wing disc ML-DmD32    5 haltere disc ML-DmD17-c3    5 eye-antennal disc ML-DmD11    2 antennal disc ML-DmD20-c5    2 mixed discs ML-DmD4-c1    2 CNS ML-DmBG1-c1    5 CNS ML-DmBG2-c2    5 tumorous blood cells mbn2    3 ovary fGS/OSS    0 ovary OSC    0 ovary OSS    3 Expression Level Scale  Very low   Low   Moderate  log, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+    2 Schneider line 2 Sg4    2 embryonic 1182-4H    5 embryonic GM2    0 embryonic Kc167    0 embryonic S1    1 embryonic S3    0 leg disc CME L1    2 wing disc CME-W2    0 wing disc ML-DmD8    8 wing disc ML-DmD9    5 wing disc ML-DmD16-c3    8 wing disc ML-DmD21    0 wing disc ML-DmD32    5 haltere disc ML-DmD17-c3    5 eye-antennal disc ML-DmD11    2 antennal disc ML-DmD20-c5    2 mixed discs ML-DmD4-c1    2 CNS ML-DmBG1-c1    5 CNS ML-DmBG2-c2    5 tumorous blood cells mbn2    3 ovary fGS/OSS    0 ovary OSC    0 ovary OSS    3 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    2 Schneider line 2 Sg4    2 embryonic 1182-4H    5 embryonic GM2    0 embryonic Kc167    0 embryonic S1    1 embryonic S3    0 leg disc CME L1    2 wing disc CME-W2    0 wing disc ML-DmD8    8 wing disc ML-DmD9    5 wing disc ML-DmD16-c3    8 wing disc ML-DmD21    0 wing disc ML-DmD32    5 haltere disc ML-DmD17-c3    5 eye-antennal disc ML-DmD11    2 antennal disc ML-DmD20-c5    2 mixed discs ML-DmD4-c1    2 CNS ML-DmBG1-c1    5 CNS ML-DmBG2-c2    5 tumorous blood cells mbn2    3 ovary fGS/OSS    0 ovary OSC    0 ovary OSS    3 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    2 Schneider line 2 Sg4    2 embryonic 1182-4H    5 embryonic GM2    0 embryonic Kc167    0 embryonic S1    1 embryonic S3    0 leg disc CME L1    2 wing disc CME-W2    0 wing disc ML-DmD8    8 wing disc ML-DmD9    5 wing disc ML-DmD16-c3    8 wing disc ML-DmD21    0 wing disc ML-DmD32    5 haltere disc ML-DmD17-c3    5 eye-antennal disc ML-DmD11    2 antennal disc ML-DmD20-c5    2 mixed discs ML-DmD4-c1    2 CNS ML-DmBG1-c1    5 CNS ML-DmBG2-c2    5 tumorous blood cells mbn2    3 ovary fGS/OSS    0 ovary OSC    0 ovary OSS    3 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Cell Line   Expression Level Schneider line 2 S2R+     Schneider line 2 Sg4     embryonic 1182-4H     embryonic GM2     embryonic Kc167     embryonic S1     embryonic S3     leg disc CME L1     wing disc CME-W2     wing disc ML-DmD8     wing disc ML-DmD9     wing disc ML-DmD16-c3     wing disc ML-DmD21     wing disc ML-DmD32     haltere disc ML-DmD17-c3     eye-antennal disc ML-DmD11     antennal disc ML-DmD20-c5     mixed discs ML-DmD4-c1     CNS ML-DmBG1-c1     CNS ML-DmBG2-c2     tumorous blood cells mbn2     ovary fGS/OSS     ovary OSC     ovary OSS
modENCODE Treatments RNA-Seq
modENCODE Treatment Expression Data (modENCODE_mRNA-Seq_treatments)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    1 cold shock, 4-day adult    1 heat shock, 4-day adult    0 Cadmium 50 mM 6 hrs, larvae L3    0 Cadmium 50 mM 12 hrs, larvae L3    0 Cadmium 50 mM 48 hrs, 4-day adult    1 Cadmium 100 mM 48 hrs, 4-day adult    1 Copper 0.5 mM 12 hrs, larvae L3    0 Copper 15 mM 48 hrs, 4-day adult    0 Zinc 5 mM 12 hrs, larvae L3    0 Zinc 4.5 mM 48 hrs, 4-day adult    0 Ethanol 2.5% 3 hrs, larvae L3    1 Ethanol 5% 3 hrs, larvae L3    0 Ethanol 10% 3 hrs, larvae L3    0 Caffeine 1.5 mg/ml 4 hrs, larvae L3    0 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    0 Caffeine 25 mg/ml 48 hrs, 4-day adult    1 Paraquat 5 mM 48 hrs, 4-day adult    0 Paraquat 10 mM 48 hrs, 4-day adult    1 Rotenone 2 μg 12 hrs, larvae L3    0 Rotenone 8 μg 12 hrs, larvae L3    0 Expression Level Scale  Very low   Low   Moderate  Linear, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult    1 cold shock, 4-day adult    1 heat shock, 4-day adult    0 Cadmium 50 mM 6 hrs, larvae L3    0 Cadmium 50 mM 12 hrs, larvae L3    0 Cadmium 50 mM 48 hrs, 4-day adult    1 Cadmium 100 mM 48 hrs, 4-day adult    1 Copper 0.5 mM 12 hrs, larvae L3    0 Copper 15 mM 48 hrs, 4-day adult    0 Zinc 5 mM 12 hrs, larvae L3    0 Zinc 4.5 mM 48 hrs, 4-day adult    0 Ethanol 2.5% 3 hrs, larvae L3    1 Ethanol 5% 3 hrs, larvae L3    0 Ethanol 10% 3 hrs, larvae L3    0 Caffeine 1.5 mg/ml 4 hrs, larvae L3    0 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    0 Caffeine 25 mg/ml 48 hrs, 4-day adult    1 Paraquat 5 mM 48 hrs, 4-day adult    0 Paraquat 10 mM 48 hrs, 4-day adult    1 Rotenone 2 μg 12 hrs, larvae L3    0 Rotenone 8 μg 12 hrs, larvae L3    0 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    1 cold shock, 4-day adult    1 heat shock, 4-day adult    0 Cadmium 50 mM 6 hrs, larvae L3    0 Cadmium 50 mM 12 hrs, larvae L3    0 Cadmium 50 mM 48 hrs, 4-day adult    1 Cadmium 100 mM 48 hrs, 4-day adult    1 Copper 0.5 mM 12 hrs, larvae L3    0 Copper 15 mM 48 hrs, 4-day adult    0 Zinc 5 mM 12 hrs, larvae L3    0 Zinc 4.5 mM 48 hrs, 4-day adult    0 Ethanol 2.5% 3 hrs, larvae L3    1 Ethanol 5% 3 hrs, larvae L3    0 Ethanol 10% 3 hrs, larvae L3    0 Caffeine 1.5 mg/ml 4 hrs, larvae L3    0 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    0 Caffeine 25 mg/ml 48 hrs, 4-day adult    1 Paraquat 5 mM 48 hrs, 4-day adult    0 Paraquat 10 mM 48 hrs, 4-day adult    1 Rotenone 2 μg 12 hrs, larvae L3    0 Rotenone 8 μg 12 hrs, larvae L3    0 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    1 cold shock, 4-day adult    1 heat shock, 4-day adult    0 Cadmium 50 mM 6 hrs, larvae L3    0 Cadmium 50 mM 12 hrs, larvae L3    0 Cadmium 50 mM 48 hrs, 4-day adult    1 Cadmium 100 mM 48 hrs, 4-day adult    1 Copper 0.5 mM 12 hrs, larvae L3    0 Copper 15 mM 48 hrs, 4-day adult    0 Zinc 5 mM 12 hrs, larvae L3    0 Zinc 4.5 mM 48 hrs, 4-day adult    0 Ethanol 2.5% 3 hrs, larvae L3    1 Ethanol 5% 3 hrs, larvae L3    0 Ethanol 10% 3 hrs, larvae L3    0 Caffeine 1.5 mg/ml 4 hrs, larvae L3    0 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    0 Caffeine 25 mg/ml 48 hrs, 4-day adult    1 Paraquat 5 mM 48 hrs, 4-day adult    0 Paraquat 10 mM 48 hrs, 4-day adult    1 Rotenone 2 μg 12 hrs, larvae L3    0 Rotenone 8 μg 12 hrs, larvae L3    0 Expression Level Scale  Extremely high  log, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    1 cold shock, 4-day adult    1 heat shock, 4-day adult    0 Cadmium 50 mM 6 hrs, larvae L3    0 Cadmium 50 mM 12 hrs, larvae L3    0 Cadmium 50 mM 48 hrs, 4-day adult    1 Cadmium 100 mM 48 hrs, 4-day adult    1 Copper 0.5 mM 12 hrs, larvae L3    0 Copper 15 mM 48 hrs, 4-day adult    0 Zinc 5 mM 12 hrs, larvae L3    0 Zinc 4.5 mM 48 hrs, 4-day adult    0 Ethanol 2.5% 3 hrs, larvae L3    1 Ethanol 5% 3 hrs, larvae L3    0 Ethanol 10% 3 hrs, larvae L3    0 Caffeine 1.5 mg/ml 4 hrs, larvae L3    0 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    0 Caffeine 25 mg/ml 48 hrs, 4-day adult    1 Paraquat 5 mM 48 hrs, 4-day adult    0 Paraquat 10 mM 48 hrs, 4-day adult    1 Rotenone 2 μg 12 hrs, larvae L3    0 Rotenone 8 μg 12 hrs, larvae L3    0 Expression Level Scale  Very low   Low   Moderate  log, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult    1 cold shock, 4-day adult    1 heat shock, 4-day adult    0 Cadmium 50 mM 6 hrs, larvae L3    0 Cadmium 50 mM 12 hrs, larvae L3    0 Cadmium 50 mM 48 hrs, 4-day adult    1 Cadmium 100 mM 48 hrs, 4-day adult    1 Copper 0.5 mM 12 hrs, larvae L3    0 Copper 15 mM 48 hrs, 4-day adult    0 Zinc 5 mM 12 hrs, larvae L3    0 Zinc 4.5 mM 48 hrs, 4-day adult    0 Ethanol 2.5% 3 hrs, larvae L3    1 Ethanol 5% 3 hrs, larvae L3    0 Ethanol 10% 3 hrs, larvae L3    0 Caffeine 1.5 mg/ml 4 hrs, larvae L3    0 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    0 Caffeine 25 mg/ml 48 hrs, 4-day adult    1 Paraquat 5 mM 48 hrs, 4-day adult    0 Paraquat 10 mM 48 hrs, 4-day adult    1 Rotenone 2 μg 12 hrs, larvae L3    0 Rotenone 8 μg 12 hrs, larvae L3    0 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    1 cold shock, 4-day adult    1 heat shock, 4-day adult    0 Cadmium 50 mM 6 hrs, larvae L3    0 Cadmium 50 mM 12 hrs, larvae L3    0 Cadmium 50 mM 48 hrs, 4-day adult    1 Cadmium 100 mM 48 hrs, 4-day adult    1 Copper 0.5 mM 12 hrs, larvae L3    0 Copper 15 mM 48 hrs, 4-day adult    0 Zinc 5 mM 12 hrs, larvae L3    0 Zinc 4.5 mM 48 hrs, 4-day adult    0 Ethanol 2.5% 3 hrs, larvae L3    1 Ethanol 5% 3 hrs, larvae L3    0 Ethanol 10% 3 hrs, larvae L3    0 Caffeine 1.5 mg/ml 4 hrs, larvae L3    0 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    0 Caffeine 25 mg/ml 48 hrs, 4-day adult    1 Paraquat 5 mM 48 hrs, 4-day adult    0 Paraquat 10 mM 48 hrs, 4-day adult    1 Rotenone 2 μg 12 hrs, larvae L3    0 Rotenone 8 μg 12 hrs, larvae L3    0 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    1 cold shock, 4-day adult    1 heat shock, 4-day adult    0 Cadmium 50 mM 6 hrs, larvae L3    0 Cadmium 50 mM 12 hrs, larvae L3    0 Cadmium 50 mM 48 hrs, 4-day adult    1 Cadmium 100 mM 48 hrs, 4-day adult    1 Copper 0.5 mM 12 hrs, larvae L3    0 Copper 15 mM 48 hrs, 4-day adult    0 Zinc 5 mM 12 hrs, larvae L3    0 Zinc 4.5 mM 48 hrs, 4-day adult    0 Ethanol 2.5% 3 hrs, larvae L3    1 Ethanol 5% 3 hrs, larvae L3    0 Ethanol 10% 3 hrs, larvae L3    0 Caffeine 1.5 mg/ml 4 hrs, larvae L3    0 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    0 Caffeine 25 mg/ml 48 hrs, 4-day adult    1 Paraquat 5 mM 48 hrs, 4-day adult    0 Paraquat 10 mM 48 hrs, 4-day adult    1 Rotenone 2 μg 12 hrs, larvae L3    0 Rotenone 8 μg 12 hrs, larvae L3    0 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Treatment   Expression Level extended cold, 4-day adult     cold shock, 4-day adult     heat shock, 4-day adult     Cadmium 50 mM 6 hrs, larvae L3     Cadmium 50 mM 12 hrs, larvae L3     Cadmium 50 mM 48 hrs, 4-day adult     Cadmium 100 mM 48 hrs, 4-day adult     Copper 0.5 mM 12 hrs, larvae L3     Copper 15 mM 48 hrs, 4-day adult     Zinc 5 mM 12 hrs, larvae L3     Zinc 4.5 mM 48 hrs, 4-day adult     Ethanol 2.5% 3 hrs, larvae L3     Ethanol 5% 3 hrs, larvae L3     Ethanol 10% 3 hrs, larvae L3     Caffeine 1.5 mg/ml 4 hrs, larvae L3     Caffeine 2.5 mg/ml 48 hrs, 4-day adult     Caffeine 25 mg/ml 48 hrs, 4-day adult     Paraquat 5 mM 48 hrs, 4-day adult     Paraquat 10 mM 48 hrs, 4-day adult     Rotenone 2 μg 12 hrs, larvae L3     Rotenone 8 μg 12 hrs, larvae L3
Expression Clusters
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0004002
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele lethal wb09437 wbBMW22 wbBMW32 wbCH18 wbCH20 wbCH38 wbCH41 wbCH57 wbCH67 wbCH70 wbCR1 wbDM10 wbGM2 wbHG7 wbHG9 wbHG10 wbHG14 wbHG16 wbHG17 wbHG18 wbHG19 wbHG24 wbHG26 wbL412 wbOK14 wbPA43 wbPI5 wbSF11 wbSF19A wbSF20 wbSF25 wbSF30 lethal, with Scer\GAL4Act5C.PU wbGD1560 lethal | embryonic stage | recessive wb09437 wb10002 lethal | recessive wb09437 wb10002 wbCH18 wbCH20 wbCH38 wbCH41 wbCH57 wbCH67 wbCH70 wbCR1 wbDM10 wbH155 wbk00805 wbk05612 wbk06511 wbk06520 wbk08909 wbk13507 wbk14208 wbOK14 wbSF11 wbSF19A wbSF20 wbSF25 wbSF30 viable wb1 wb3 wb4 viable, with Scer\GAL4pnr-MD237 wbGD1560 Sterility Allele fertile wb3 wb4 Other Phenotypes Allele neuroanatomy defective | third instar larval stage, with Scer\GAL4hh-Gal4 wbGD1560 visible, with Scer\GAL4pnr-MD237 wbGD1560 visible | recessive wb1 wbGT6 wbk06091 wbk16716 Phenotype manifest in Allele chaeta | supernumerary, with Scer\GAL4pnr-MD237 wbGD1560 dorsal multidendritic neuron ddaC | third instar larval stage, with Scer\GAL4hh-Gal4 wbGD1560 embryo | germline clone wb4Y18 embryonic/first instar larval cuticle | dorsal wbk05612 wbk00805 embryonic/larval dorsal trunk wbk05612 wbHG10 embryonic/larval dorsal vessel wbk05612 wbk00805 embryonic/larval pericardial cell wbk05612 wbk00805 embryonic/larval somatic muscle wbk05612 wbHG10 eye photoreceptor cell | somatic clone wbk05612 gastrula embryo wbk05612 wbHG10 germ band | germline clone wb4Y18 gonad | embryonic stage (with wb37.01) wb146.21 gonad | embryonic stage (with wb146.21) wb37.01 gonadal sheath proper primordium | embryonic stage (with wb37.01) wb146.21 gonadal sheath proper primordium | embryonic stage (with wb146.21) wb37.01 ventral oblique muscle wbk05612 wbHG10 visceral mesoderm | embryonic stage (with wb37.01) wb146.21 visceral mesoderm | embryonic stage (with wb146.21) wb37.01 wing wbGT6 wb1 wb09437 wb4 wb3 wbk16716 wing, with Scer\GAL4Bx-MS1096 wbGD1560
Classical Alleles ( 78 )
For All Classical Alleles Show
Allele of wb Class Mutagen Stocks Known lesion wbSF11 triethylenemelamine 2 -- wbSF20 ethyl methanesulfonate 2 -- wb09437 P-element activity 1 Yes wb3 ethyl methanesulfonate 1 -- wbBG02232 P-element activity 1 -- wbc02188 piggyBac transposase 1 -- wbc03899 piggyBac transposase 1 -- wbd03532 P-element activity 1 -- wbd03639 P-element activity 1 -- wbe00066 piggyBac transposase 1 -- wbe00123 piggyBac transposase 1 -- wbe02629 piggyBac transposase 1 -- wbEY11753 P-element activity 1 -- wbf03903 piggyBac transposase 1 -- wbf06277 piggyBac transposase 1 -- wbk06511 P-element activity 1 -- wbk13507 P-element activity 1 -- wbMB06467 1 -- wbMB09221 1 -- wbMI00260 1 -- wbMI07688 1 -- wbNP0862 1 -- wb10002 P-element activity 0 Yes wb146.21 ethyl methanesulfonate 0 -- wb1 ethyl methanesulfonate 0 -- wb37.01 ethyl methanesulfonate 0 -- wb4418 0 -- wb4 ethyl methanesulfonate 0 -- wb4Y18 loss of function allele 0 -- wb6r28 gamma ray 0 -- wb91g2 ethyl methanesulfonate 0 -- wbBMW22 ethyl methanesulfonate 0 -- wbBMW32 ethyl methanesulfonate 0 -- wbCH18 ethyl methanesulfonate 0 -- wbCH20 ethyl methanesulfonate 0 -- wbCH38 ethyl methanesulfonate 0 -- wbCH41 ethyl methanesulfonate 0 -- wbCH57 ethyl methanesulfonate 0 -- wbCH67 ethyl methanesulfonate 0 -- wbCH70 ethyl methanesulfonate 0 -- wbCR1 ethyl methanesulfonate 0 -- wbd01445 P-element activity 0 -- wbDM10 ethyl methanesulfonate 0 -- wbDTD121 0 -- wbf03847 piggyBac transposase 0 -- wbGM2 ethyl methanesulfonate 0 -- wbGR301 gamma ray 0 -- wbGT6 0 -- wbGV9 0 -- wbH155 P-element activity 0 -- wbH68 gamma ray 0 -- wbHG10 ethyl methanesulfonate 0 -- wbHG14 ethyl methanesulfonate 0 -- wbHG16 ethyl methanesulfonate 0 -- wbHG17 ethyl methanesulfonate 0 -- wbHG18 ethyl methanesulfonate 0 -- wbHG19 ethyl methanesulfonate 0 -- wbHG24 ethyl methanesulfonate 0 -- wbHG26 ethyl methanesulfonate 0 -- wbHG7 ethyl methanesulfonate 0 -- wbHG9 ethyl methanesulfonate 0 -- wbIK4 0 -- wbk00805 P-element activity 0 -- wbk05612 P-element activity 0 -- wbk06091 P-element activity 0 -- wbk06520 P-element activity 0 -- wbk08909 P-element activity 0 -- wbk14208 P-element activity 0 -- wbk16716 P-element activity 0 Yes wbL412 ethyl methanesulfonate 0 -- wbOK14 ethyl methanesulfonate 0 -- wbPA43 ethyl methanesulfonate 0 -- wbPI5 PM hybrid dysgenesis 0 -- wbrL918 P-element activity 0 Yes wbSF19A ethyl methanesulfonate 0 -- wbSF25 ethyl methanesulfonate 0 -- wbSF30 ethyl methanesulfonate X ray 0 -- wbunspecified 0 --
Alleles Carried on Transgenic Constructs ( 5 )
For All Alleles Carried on Transgenic Constructs Show
Allele of wb Class Mutagen Stocks Known lesion wbGD1560 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes wbJF03238 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes wbKK101561 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes wbKK113342 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes wbNIG.15288R in vitro construct - RNAi in vitro construct - regulatory fusion 0 Yes
Aneuploid Aberrations
Not disrupted in	Df(2L)A48 (Fossett et al., 1994, Gubb et al., 1990, Ashburner et al., 1982) Df(2L)A63 (Ashburner et al., 1982, Fossett et al., 1994) Df(2L)A72 (Fossett et al., 1994, Ashburner et al., 1982) Df(2L)A178 (Fossett et al., 1994, Ashburner et al., 1982) Df(2L)A217 (Roote, 2000.7.3, Roote, 2009.11.24, Ashburner et al., 1982, Fossett et al., 1994) Df(2L)A220 (Ashburner et al., 1982, Fossett et al., 1994) Df(2L)A245 (Fossett et al., 1994, Ashburner et al., 1982) Df(2L)A260 (Ashburner et al., 1982) Df(2L)A264 (Ashburner et al., 1982, Fossett et al., 1994) Df(2L)A266 (Fossett et al., 1994, Ashburner et al., 1982) Df(2L)A267 (Fossett et al., 1994, Ashburner et al., 1982) Df(2L)A379 (Fossett et al., 1994, Ashburner et al., 1982) Df(2L)A400 (Fossett et al., 1994, Ashburner et al., 1982) Df(2L)A445 (Ashburner et al., 1982, Fossett et al., 1994) Df(2L)Adh-nBR102 (Fossett et al., 1994) Df(2L)Adh-nBR105 (Fossett et al., 1994) Df(2L)Adh-nBR106 (Fossett et al., 1994) Df(2L)Adh-nBR107 (Fossett et al., 1994) Df(2L)Adh-nBR118 (Fossett et al., 1994) Df(2L)Adh-nBR119 (Fossett et al., 1994) Df(2L)Adh-nBR121 (Fossett et al., 1994) Df(2L)Adh-nBR122 (Fossett et al., 1994) Df(2L)Adh-nBR126 (Fossett et al., 1994) Df(2L)Adh-nBR127 (Fossett et al., 1994) Df(2L)Adh-nBR128 (Fossett et al., 1994) Df(2L)Adh-nBR129 (Fossett et al., 1994) Df(2L)b75 (Woodruff and Ashburner, 1979, Woodruff and Ashburner, 1979) Df(2L)b77c (Roote, 2000.7.3) Df(2L)b80c1 (Ashburner et al., 1982) Df(2L)b88f40 (Roote, 2000.7.3) Df(2L)b88f43 (Roote, 1996.8) Df(2L)b88g96 (Roote, 1996.8) Df(2L)b89e8 (Roote, 2000.7.3) Df(2L)b89e72 (Roote, 2000.7.3) Df(2L)EP(2)2039-rv4 (Roote, 2000.6.13) Df(2L)fn2 (Woodruff and Ashburner, 1979, O'Donnell et al., 1977, Ashburner et al., 1982) Df(2L)fn3 (O'Donnell et al., 1977, Ashburner et al., 1982, Woodruff and Ashburner, 1979, Woodruff and Ashburner, 1979) Df(2L)fn15 (Ashburner et al., 1982, O'Donnell et al., 1977) Df(2L)fn27 (Ashburner et al., 1982, O'Donnell et al., 1977) Df(2L)Scorv4 (Woodruff and Ashburner, 1979, Woodruff and Ashburner, 1979) Df(2L)TE35B-1 (Gubb et al., 1985) Df(2L)TE35B-6 (Gubb et al., 1985) Df(2L)TE35B-7 (Gubb et al., 1985) Df(2L)TE35B-11 (Gubb et al., 1985) Df(2L)TE35B-12 (Gubb et al., 1985) Df(2L)TE35BC-1 (Gubb et al., 1984) Df(2L)TE35BC-3 (Gubb et al., 1984) Df(2L)TE35BC-4 (Gubb et al., 1984) Df(2L)TE35BC-7 (Gubb et al., 1984) Df(2L)TE35BC-8 (Gubb et al., 1984) Df(2L)TE35BC-24 (Gubb et al., 1984) Df(2L)TE35BC-28 (Gubb et al., 1984) Df(2L)TE35BC-34 (Gubb et al., 1984) Df(2L)TE35BC-35 (Gubb et al., 1984) In(2L)TE35B-13 (Gubb et al., 1985) T(2;3)H147 (Roote, 1997.6.2) T(2;3)Scorv7 (Woodruff and Ashburner, 1979) T(Y;2)A80DR15P (Woodruff and Ashburner, 1979) T(Y;2)J165DP58P (Woodruff and Ashburner, 1979, Woodruff and Ashburner, 1979) T(Y;2)R15DJ165P (Woodruff and Ashburner, 1979, Woodruff and Ashburner, 1979) Tp(2;2)A446 (Fossett et al., 1994, Ashburner et al., 1982)
Disrupted in	Df(2L)64j (Woodruff and Ashburner, 1979, O'Donnell et al., 1977, Woodruff and Ashburner, 1979) Df(2L)A47 (Fossett et al., 1994, Gubb et al., 1990, Ashburner et al., 1982) Df(2L)A215 (Fossett et al., 1994, Ashburner et al., 1982) Df(2L)A246 (Fossett et al., 1994, Ashburner et al., 1982) Df(2L)A263 (Ashburner et al., 1982) Df(2L)A337 (Fossett et al., 1994) Df(2L)A376 (Fossett et al., 1994, Ashburner et al., 1982) Df(2L)A377 (Ashburner et al., 1982) Df(2L)Adh-nBR100 (Roote et al., 1996, Roote, 1996.1.11, Roote, 1996.8, Fossett et al., 1994) Df(2L)Adh-nBR101 (Fossett et al., 1994) Df(2L)Adh-nBR103 (Roote, 1996.8, Fossett et al., 1994, Roote, 1996.1.11) Df(2L)Adh-nBR117 (Fossett et al., 1994) Df(2L)Adh-nBR120 (Roote, 1996.1.11, Fossett et al., 1994, Roote, 1996.8) Df(2L)Adh-nBR125 (Roote, 1996.8, Roote, 1996.1.11, Fossett et al., 1994) Df(2L)Adh-nBR130 (Fossett et al., 1994) Df(2L)Adh-nBR131 (Fossett et al., 1994) Df(2L)b75 (Gubb et al., 1990, Roote, 2000.7.3) Df(2L)b78j (Roote, 2009.11.24, Roote, 1995.3.27, Roote, 2000.7.3, Alexandrova et al., 1996) Df(2L)b79b4 (Alexandrova et al., 1996, Roote, 1995.3.27, Roote, 2000.7.3) Df(2L)b84a7 (BDGP Project Members, 1994-1999) Df(2L)b84h50 (BDGP Project Members, 1994-1999) Df(2L)b85f1 (Roote, 1995.3.27, Roote, 2000.7.3) Df(2L)ED8185 (Roote, 2009.11.24, Roote, 2009.11.24) Df(2L)ED8186 (Roote, 2009.11.24, Roote, 2009.11.24) Df(2L)el17 (Roote et al., 1996) Df(2L)el77 (Roote et al., 1996, Woodruff and Ashburner, 1979, Woodruff and Ashburner, 1979) Df(2L)el80f1 (Schock and Perrimon, 2003) Df(2L)el81i1 (Roote et al., 1996) Df(2L)fn1 (Ashburner et al., 1982, O'Donnell et al., 1977, Woodruff and Ashburner, 1979, Woodruff and Ashburner, 1979) Df(2L)fn5 (Ashburner et al., 1982, O'Donnell et al., 1977) Df(2L)fn7 (Woodruff and Ashburner, 1979, Ashburner et al., 1982, Gubb et al., 1985, Martin et al., 1999, Woodruff and Ashburner, 1979, O'Donnell et al., 1977) Df(2L)fn12 (O'Donnell et al., 1977, Ashburner et al., 1982, Woodruff and Ashburner, 1979) Df(2L)fn26 (Ashburner et al., 1982, O'Donnell et al., 1977) Df(2L)fn30 (Ashburner et al., 1982, O'Donnell et al., 1977) Df(2L)fn31 (O'Donnell et al., 1977, Ashburner et al., 1982) Df(2L)fn36 (Ashburner et al., 1982, Martin et al., 1999, O'Donnell et al., 1977, Roote et al., 1996) Df(2L)GT4 (Gubb et al., 1990) Df(2L)GT5 (Gubb et al., 1990) Df(2L)k07245-mr11 (Roote, 2000.6.13) Df(2L)k11509-rv18 (Roote, 2000.6.13) Df(2L)noc13 (Roote et al., 1996) Df(2L)osp38 (Roote, 1996.8) Df(2L)rN149-rv3 (Roote, 2000.6.13) Df(2L)TE35B-2 (Gubb et al., 1985) Df(2L)TE35B-3 (Gubb et al., 1985) Df(2L)TE35B-4 (Gubb et al., 1985) Df(2L)TE35B-5 (Gubb et al., 1985) Df(2L)TE35B-8 (Gubb et al., 1985) Df(2L)TE35B-9 (Gubb et al., 1985) Df(2L)TE35B-10 (Gubb et al., 1985, Roote et al., 1996) Df(2L)TE35B-15 (Gubb et al., 1985, Roote et al., 1996) Df(2L)TE35B-300 (Roote et al., 1996) Df(2L)TE35BC-6 (Gubb et al., 1984) Df(2L)TE35BC-23 (Gubb et al., 1984) Df(2L)TE35BC-29 (Gubb et al., 1984) Df(2L)TE35BC-31 (Gubb et al., 1984) Df(2L)TE35D-24 (Roote, 1998.3.17) Df(2L)W (Woodruff and Ashburner, 1979, Woodruff and Ashburner, 1979) In(2L)75c (Woodruff and Ashburner, 1979, Woodruff and Ashburner, 1979) In(2L)75cLC158.1R (Woodruff and Ashburner, 1979, Woodruff and Ashburner, 1979, Roote et al., 1996, ) In(2L)75cLC163R   T(2;4)GT6 (Roote, 1998.6.3, Gubb et al., 1990) Ts(2Lt;3Lt)H147+Ts(2Rt;3Rt)TE35B-8 (Roote et al., 1996) Ts(YSt;2Lt)G74+Ts(YSt;2Rt)A80 (Woodruff and Ashburner, 1979)
Partially disrupted in	T(2;4)GT6 (Roote, 1999.6.8)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD1560} NA P{KK101561} NA P{NIG.15288R} NA P{TRiP.JF03238} NA
Insertions
	Type of insertions Name Expression data insertion of enhancer trap P{lacW}k06520 No P{lacW}l(2)SH0496SH0496 No P{lacW}wbH155 No P{lacW}wbk00805 No P{lacW}wbk05612 No P{lacW}wbk06091 No P{lacW}wbk06511 No P{lacW}wbk08909 No P{lacW}wbk13507 No P{lacW}wbk14208 No P{lacW}wbk16716 No P{MTW}313e No P{PZ}wb09437 No P{PZ}wb10002 No P{PZ}wbrL918 No miscellaneous insertions Mi{MIC}wbMI00260 NA Mi{MIC}wbMI07688 NA P{GT1}wbBG02232 NA PBac{PB}wbc02188 NA PBac{PB}wbc03899 NA PBac{RB}wbe00066 NA PBac{RB}wbe00123 NA PBac{RB}wbe02629 NA PBac{WH}wbf03847 NA PBac{WH}wbf03903 NA PBac{WH}wbf06277 NA insertion of enhancer trap binary system Mi{ET1}wbMB06467 No Mi{ET1}wbMB09221 No P{GawB}wbNP0862 No insertion of mobile activating element P{EPgy2}wbEY11753 NA P{XP}wbd01445 NA P{XP}wbd03532 NA P{XP}wbd03639 NA
Gene Ontology: Function, Process & Cellular Component ( 10 unique terms )
Terms Based on Experimental Evidence ( 4 terms )
Molecular Function ( 0 terms)
Biological Process
CV term Evidence References
digestive tract mesoderm development inferred from mutant phenotype (Weyers et al., 2011) gonad development inferred from mutant phenotype (Weyers et al., 2011) imaginal disc-derived wing morphogenesis inferred from mutant phenotype (Carreira et al., 2011)
Cellular Component
CV term Evidence References
basal lamina inferred from direct assay (Baumgartner and Martin, 1997)
Terms Based on Predictions or Assertions ( 7 terms )
Molecular Function
CV term Evidence References
receptor binding inferred from electronic annotation with InterPro:IPR009254 (FlyBase Curators et al., 2004-)
Biological Process
CV term Evidence References
regulation of cell adhesion inferred from electronic annotation with InterPro:IPR009254 (FlyBase Curators et al., 2004-) regulation of cell migration inferred from electronic annotation with InterPro:IPR009254 (FlyBase Curators et al., 2004-) regulation of embryonic development inferred from electronic annotation with InterPro:IPR009254 (FlyBase Curators et al., 2004-)
Cellular Component
CV term Evidence References
basal lamina inferred from sequence or structural similarity (Ashburner et al., 1999) non-traceable author statement (Martin, 1999.3.16) basement membrane inferred from sequence or structural similarity (Hynes and Zhao, 2000) laminin-1 complex inferred from electronic annotation with InterPro:IPR009254 (FlyBase Curators et al., 2004-)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions wb allele Gene References unspecified sli (MacMullin and Jacobs, 2006)
External Data
Linkouts	DroID - A comprehensive database of gene and protein interactions. • FBgn0261563 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 43946
Orthologs
OrthoDB Orthologs (31) - based on analysis using Dmel annotation version 5.41
OrthoDB Ortholog Groups
	OrthoDB orthology group searches (Waterhouse et al., 2011, Nucleic Acids Res. 39(Database issue): D283--D288) Drosophila inclusive ortholog search EOG6RR72M Dipteran inclusive ortholog search EOG65DWX9 Insect inclusive ortholog search EOG6V423H Arthropod inclusive ortholog search EOG659ZW9 Metazoa inclusive ortholog search EOG66QKK2
Orthologs in Drosophila Species (EOG6RR72M)
Organism Common Name Gene AAA Syntenic Ortholog Multiple Dmel Genes in this Orthologous Group Drosophila melanogaster fruit fly  Dmel\wb     Drosophila simulans   Dsim\GD23957 Y   Drosophila sechellia   Dsec\GM15516 Y   Drosophila erecta   Dere\GG23914 Y   Drosophila yakuba   Dyak\GE19027 Y   Drosophila ananassae   Dana\GF14282 Y   Drosophila pseudoobscura pseudoobscura   Dpse\GA13629 Y   Drosophila persimilis   Dper\GL21262 Y   Drosophila willistoni   Dwil\GK15035 Y   Drosophila virilis   Dvir\GJ18176 Y   Drosophila mojavensis   Dmoj\GI12813 Y   Drosophila grimshawi   Dgri\GH11139 Y
Orthologs in non-Drosophila Dipterans (EOG65DWX9)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Aedes aegypti Yellow fever mosquito  Aaeg\AAEL001477   Anopheles gambiae Malaria mosquito  Agam\AGAP007849   Culex quinquefasciatus Southern house mosquito  Cqui\CPIJ004683
Orthologs in non-Dipteran Insects (EOG6V423H)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Apis mellifera Western honey bee  Amel\GB53931   Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG011291   Acromyrmex echinatior Panamanian leafcutter ant  Aech\AECH14088   Atta cephalotes Leafcutter ant  Acep\ACEP27273   Camponotus floridanus Florida carpenter ant  Cflo\CFLO16327   Harpegnathos saltator Jerdons jumping ant  Hsal\HSAL20584   Linepithema humile Argentine ant  Lhum\LH10455   Pogonomyrmex barbatus Red harvester ant  Pbar\PB22276   Solenopsis invicta Red fire ant  Sinv\SINV22898   Acyrthosiphon pisum Pea aphid  Apim\ACYPI004055   Bombyx mori Silkmoth  Bmor\BGIBMGA006098   Pediculus humanus Human body louse  Phum\PHUM394240   Tribolium castaneum Red flour beetle  Tcas\TC014773
Orthologs in non-Insect Arthropods (EOG659ZW9)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Daphnia pulex Water flea  Dpux\Vav3
Orthologs in non-Arthropod Metazoa (EOG66QKK2)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Caenorhabditis elegans Nematode  Cele\lam-3   Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_003926gn
Human Orthologs (0)
Gene OMIM HGNC
AAA Orthologs (11) based on analysis using Dmel annotation version 4.3
Organism Gene Drosophila simulans Dsim\GD23957 Drosophila sechellia Dsec\GM15516 Drosophila erecta Dere\GG23914 Drosophila yakuba Dyak\GE19027 Drosophila ananassae Dana\GF14282 Drosophila pseudoobscura pseudoobscura Dpse\GA13629 Drosophila persimilis Dper\GL21262 Drosophila willistoni Dwil\GK15035 Drosophila virilis Dvir\GJ18176 Drosophila mojavensis Dmoj\GI12813 Drosophila grimshawi Dgri\GH11139
Stocks & Reagents
Stocks Listed in FlyBase ( 28 )
Harvard	- P{XP}wbd03532 - P{XP}wbd03639 - PBac{PB}wbc02188 - PBac{PB}wbc03899 - PBac{RB}wbe00066 - PBac{RB}wbe00123 - PBac{RB}wbe02629 - PBac{WH}wbf03903 - PBac{WH}wbf06277
VDRC	v102919 P{KK113342}VIE-260B v108020 P{KK101561}VIE-260B v3141 w1118; P{GD1560}v3141
	More stocks available...
Genomic Clones ( 2 )
	BACR20P10 BACR37K07 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 23 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	IP03706 IP12428 IP12628
Other clones	MIP16024
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	RH39691
Other clones	160350 176585 191845 571182 CK00390 CK01592 CK02229 EK164845 EK263360 EK294356 EN16259 FGM231G03 FGM303A05 FGM313B05 FGM320D09 IP03906 IP12528 IP14895
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0261563 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 43946
Antibody Information
	polyclonal (Martin et al., 1999)
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of
Source for database merge of	Source for merge of: CG32970 BG:DS03792.2 (FlyBase, 1996-) Source for merge of: wb BEST:CK02229 (Ashburner et al., 1999) Source for merge of: wb CG15288 (Misra, 2000.4.12) Source for merge of: wb CG32970 (FlyBase Genome Annotators, 2010)
Additional comments	Annotations CG15288 and CG32970 merged as CG42677 in release 5.25 of the genome annotation. (FlyBase Genome Annotators, 2010) "BG:DS03792.2" may correspond to "ms(2)34Fe". (Ashburner et al., 1999.10.12)
Other Comments
	One of 42 Drosophila genes identified as being most likely to reveal molecular and cellular mechanisms of nervous system development or plasticity relevant to human Mental Retardation disorders. (Inlow and Restifo, 2004) dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R+ cell morphology. (Kiger et al., 2003) New annotation (CG32970) in release 3 of the genome annotation. (FlyBase Genome Annotators, 2002-2003) wb is involved in processes requiring cell migration and cell adhesion. (Martin et al., 1999) wb has been characterised as a potential ligand of PS2 integrins by functional interaction in cell culture. (Graner et al., 1998) Identification: cDNA screen for secreted and transmembrane proteins expressed during embryogenesis. (Kopczynski et al., 1998) Mutants isolated in a screen of the second chromosome identifying genes affecting disc morphology. (Roch et al., 1998) One allele in this group has bent down wings when crossed to either the other lethals in the group or with deletions that included this locus. (O'Donnell et al., 1977) Most of the mutants are characterized by homo- or hemizygous lethality, but a visible phenotype has also been reported. O'Donnell et al., 1977 describe a bent-down-wing phenotype occurring when one of their lethals is crossed to other lethals in the same complementation group and the same phenotype when three of their lethals are crossed to deletions for the locus. Woodruff and Ashburner, 1979 describe the viable and fertile wing blister phenotype (a roughly circular area around the crossveins of the wing, forming a blister which often collapses soon after eclosion, distorting the wing blade). The allele showing this phenotype (wb1) is viable and fertile in homozygotes and hemizygotes as well as in heteroallelic combinations with lethal alleles.
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_057442 NM_165086 NM_001201877 NM_001201878 NM_001201879 NM_001201880 RefSeq (Proteins) • NP_476790 NP_723870 NP_001188806 NP_001188807 NP_001188808 NP_001188809 DDBJ / EMBL / GenBank • AA140696 AA140697 AA141179 AA141691 AA141692 AAD31714 AAF44861 AAF44862 AAF53381 AAN10875 AAO41191 AC092248 ACL83031 ADV37056 ADV37057 ADV37058 ADV37059 AE003409 AF135118 AQ025808 AQ026114 AQ026440 AQ026443 BH011482 CL844479 CZ467753 CZ468884 CZ472234 CZ473412 CZ473479 CZ477975 CZ478020 CZ480408 CZ486441 CZ486442 CZ486508 CZ486509 CZ488951 CZ488952 G00417 Entrez Gene - A searchable database of RefSeq genes. • 43946 318270 UniProtKB/TrEMBL • Q7KT92 Q8IP51 Q9XZC9
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Laminin B type IV (IPR000034) Laminin G domain (IPR001791) EGF-like, laminin (IPR002049) Laminin, N-terminal (IPR008211) Concanavalin A-like lectin/glucanases superfamily (IPR008985) Laminin I (IPR009254) Laminin II (IPR010307) EGF-like, conserved site (IPR013032) Concanavalin A-like lectin/glucanase, subgroup (IPR013320)
Linkouts
	DroID - A comprehensive database of gene and protein interactions. • FBgn0261563 DRSC - Results from RNAi screens. • FBgn0261563 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0004002 FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0261563 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 43946 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 43946 modMine - Data generated by the modENCODE project. • FBgn0261563
Synonyms & Secondary IDs ( 31 )
Reported As
Symbol Synonym	A1 (Ashburner et al., 1980, O'Donnell et al., 1977) BEST:CK02229   BG:DS03792.1 (Ashburner et al., 1999.10.12, Ashburner et al., 1999) BG:DS03792.2 (Bayraktaroglu, 2000.4.8, Ashburner et al., 1999.10.12, Ashburner et al., 1999, Ashburner et al., 1999, ) CG15288 (Keleman et al., 2009.8.5, Bhutkar et al., 2008, Ashburner, 2000.3.25, Perkins et al., 2009) CG32970 (Keleman et al., 2009.8.5) CG42677 (FlyBase Genome Annotators, 2010) CK02229 (Kopczynski et al., 1998) CT35236 (Hynes and Zhao, 2000) DLAM (Graner et al., 1998) fus5 (Weyers et al., 2011) l34Fb (Fossett et al., 1994) l(2)34Fb (Ashburner et al., 1999, The Moscow Regional Drosophila melanogaster Stock Center, Dubna, Alexandrova et al., 1996) l(2)09437   l(2)br1 (Ashburner et al., 1982, Ashburner et al., 1980, Woodruff and Ashburner, 1979, Woodruff and Ashburner, 1979, The Moscow Regional Drosophila melanogaster Stock Center, Dubna, Gubb et al., 1985, Gubb et al., 1984, Ashburner et al., 1982) LM-A/α2 (Hynes and Zhao, 2000) wb (Vanderploeg et al., 2012, Dietzl et al., 2007, Inoue and Hayashi, 2007, Kwon et al., 2008, Roote, 2009.11.24, Urbano et al., 2009, Tsai et al., 2008, Roote, 2009.11.24, Bhutkar et al., 2008, MacMullin and Jacobs, 2006, Morozova et al., 2007, Sorrosal et al., 2010, Burgler and Macdonald, 2005, Hazelett et al., 2009, Weyers et al., 2011, Han et al., 2012, Carreira et al., 2011, Garelli et al., 2012, Japanese National Institute of Genetics, 2012.5.21, Manning et al., 2012) α1,2 (Urbano et al., 2009)
Name Synonym	D-laminin α2 (Bunch et al., 1998, Graner et al., 1998) laminin (Stevens and Jacobs, 2000) Laminin A2 (Banyai and Patthy, 2004) LamininW (Urbano et al., 2011) laminin α1,2 (Brouzes and Farge, 2004, Martin et al., 1999) Laminin α1,2 (Brown et al., 2000) laminin α1,2 (Urbano et al., 2009) lethal 1 in the black-reduced region (Woodruff and Ashburner, 1979) lethal group A1 (O'Donnell et al., 1977) SGP cluster fusion defects 5 (Weyers et al., 2011) wing blister (Devenport et al., 2007, Inoue and Hayashi, 2007, Martin, 1999.3.16, Morozova et al., 2007, Sorrosal et al., 2010, Weyers et al., 2011, Han et al., 2012) wing blistered (Volk, 1999) α laminin (Inoue and Hayashi, 2007)
Secondary FlyBase IDs
	FBgn0004002 FBgn0025691 FBgn0028885 FBgn0032544 FBgn0052970
References ( 120 )
Generate a list of	All references relating to this gene ( 120 )
List References by type	Research paper  ( 51 ) Supplementary material  ( 8 ) Review  ( 7 ) Personal communication to FlyBase  ( 38 ) Abstract  ( 6 ) FlyBase analysis  ( 5 ) DNA/RNA sequence record  ( 1 ) Stock list  ( 2 ) Book  ( 1 ) Curated genome annotation  ( 1 )
Recent research papers ( 10 )
	Lindsley et al., 2013, PLoS ONE 8(2): e55915 Anent the Genomics of Spermatogenesis in Drosophila melanogaster. [FBrf0220812] Garelli et al., 2012, Science 336(6081): 579--582 Imaginal discs secrete insulin-like peptide 8 to mediate plasticity of growth and maturation. [FBrf0218214] Han et al., 2012, Neuron 73(1): 64--78 Integrins Regulate Repulsion-Mediated Dendritic Patterning of Drosophila Sensory Neurons by Restricting Dendrites in a 2D Space. [FBrf0217239] Manning et al., 2012, Cell Rep. 2(4): 1002--1013 A Resource for Manipulating Gene Expression and Analyzing cis-Regulatory Modules in the Drosophila CNS. [FBrf0219785] Vanderploeg et al., 2012, BMC Dev. Biol. 12: 8 Integrins are required for cardioblast polarisation in Drosophila. [FBrf0217831] Baycin-Hizal et al., 2011, J. Proteome Res. 10(6): 2777--2784 GlycoFly: A Database of Drosophila N-linked Glycoproteins Identified Using SPEG-MS Techniques. [FBrf0213834] Carreira et al., 2011, BMC Dev. Biol. 11: 32 Genetic basis of wing morphogenesis in Drosophila: sexual dimorphism and non-allometric effects of shape variation. [FBrf0214273] Morozova et al., 2011, Genetics 187(4): 1193--1205 Transcriptional networks for alcohol sensitivity in Drosophila melanogaster. [FBrf0214377] Urbano et al., 2011, PLoS ONE 6(9): e23893 PS Integrins and Laminins: Key Regulators of Cell Migration during Drosophila Embryogenesis. [FBrf0216260] Weyers et al., 2011, Dev. Biol. 353(2): 217--228 A genetic screen for mutations affecting gonad formation in Drosophila reveals a role for the slit/robo pathway. [FBrf0213539] Show all research papers ...
Recent reviews ( 1 )
	Broadie et al., 2011, Dev. Neurobiol. 71(11): 1102--1130 Extracellular matrix and its receptors in drosophila neural development. [FBrf0216377] Show all reviews ...