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General Information
Symbol
Dmel\ReepA
Species
D. melanogaster
Name
Receptor expression enhancing protein A
Annotation Symbol
CG42678
Feature Type
FlyBase ID
FBgn0261564
Gene Model Status
Stock Availability
Gene Summary
Receptor expression enhancing protein A (ReepA) encodes a member of the DP1/Yop1p family. It localizes to the endoplasmic reticulum (ER) and is involved in the prevention of ER-stress. [Date last reviewed: 2019-03-14] (FlyBase Gene Snapshot)
Also Known As

Reep1, REEP1 homolog

Key Links
Genomic Location
Cytogenetic map
Sequence location
Recombination map
2-101
RefSeq locus
NT_033778 REGION:22925107..22932044
Sequence
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
Function
GO Summary Ribbons
Gene Ontology (GO) Annotations (10 terms)
Molecular Function (1 term)
Terms Based on Experimental Evidence (0 terms)
Terms Based on Predictions or Assertions (1 term)
CV Term
Evidence
References
inferred from biological aspect of ancestor with PANTHER:PTN000959166
(assigned by GO_Central )
Biological Process (3 terms)
Terms Based on Experimental Evidence (2 terms)
CV Term
Evidence
References
inferred from mutant phenotype
inferred from mutant phenotype
Terms Based on Predictions or Assertions (1 term)
CV Term
Evidence
References
inferred from biological aspect of ancestor with PANTHER:PTN000959055
(assigned by GO_Central )
Cellular Component (6 terms)
Terms Based on Experimental Evidence (2 terms)
CV Term
Evidence
References
located_in presynapse
inferred from direct assay
Terms Based on Predictions or Assertions (4 terms)
CV Term
Evidence
References
inferred from biological aspect of ancestor with PANTHER:PTN000959166
(assigned by GO_Central )
inferred from biological aspect of ancestor with PANTHER:PTN000959166
(assigned by GO_Central )
inferred from biological aspect of ancestor with PANTHER:PTN000959055
(assigned by GO_Central )
is_active_in membrane
inferred from biological aspect of ancestor with PANTHER:PTN000959055
(assigned by GO_Central )
Gene Group (FlyBase)
Protein Family (UniProt)
-
Summaries
Gene Snapshot
Receptor expression enhancing protein A (ReepA) encodes a member of the DP1/Yop1p family. It localizes to the endoplasmic reticulum (ER) and is involved in the prevention of ER-stress. [Date last reviewed: 2019-03-14]
Gene Model and Products
Number of Transcripts
13
Number of Unique Polypeptides
12

Please see the JBrowse view of Dmel\ReepA for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Comments on Gene Model

Gene model reviewed during 5.53

Gene model includes transcripts encoding non-overlapping portions of the full CDS.

Alternative translation stop created by use of multiphasic reading frames within coding region.

Annotated transcripts do not represent all possible combinations of alternative exons and/or alternative promoters.

Annotated transcripts do not represent all supported alternative splices within 5' UTR.

Low-frequency RNA-Seq exon junction(s) not annotated.

Gene model reviewed during 5.48

Gene model reviewed during 5.55

Sequence Ontology: Class of Gene
Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
FBtr0302766
1573
435
FBtr0302767
1469
288
FBtr0302768
2534
288
FBtr0302769
2715
569
FBtr0302770
2755
716
FBtr0302771
2718
570
FBtr0302772
1931
408
FBtr0302773
1243
151
FBtr0336697
1321
291
FBtr0344190
2601
538
FBtr0345077
2641
685
FBtr0345078
1863
459
FBtr0345079
1823
312
Additional Transcript Data and Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
RefSeq ID
GenBank
FBpp0291906
49.5
435
8.40
FBpp0291907
32.8
288
9.08
FBpp0291908
32.8
288
9.08
FBpp0291909
63.9
569
5.26
FBpp0291910
80.7
716
5.40
FBpp0291911
64.0
570
5.26
FBpp0291912
45.3
408
4.79
FBpp0291913
16.3
151
10.91
FBpp0307678
33.7
291
8.93
FBpp0310602
60.4
538
5.23
FBpp0311307
77.2
685
5.38
FBpp0311308
51.7
459
9.48
FBpp0311309
34.9
312
10.05
Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

288 aa isoforms: ReepA-PE, ReepA-PG
Additional Polypeptide Data and Comments
Reported size (kDa)
Comments
External Data
Crossreferences
InterPro - A database of protein families, domains and functional sites
Linkouts
Sequences Consistent with the Gene Model
Nucleotide / Polypeptide Records
 
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\ReepA using the Feature Mapper tool.

External Data
Crossreferences
Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
Linkouts
Expression Data
Expression Summary Ribbons
Colored tiles in ribbon indicate that expression data has been curated by FlyBase for that anatomical location. Colorless tiles indicate that there is no curated data for that location.
For complete stage-specific expression data, view the modENCODE Development RNA-Seq section under High-Throughput Expression below.
Transcript Expression
in situ
Stage
Tissue/Position (including subcellular localization)
Reference
organism

Comment: maternally deposited

northern blot
Stage
Tissue/Position (including subcellular localization)
Reference
adult head

Comment: isoform expression analyzed

adult thorax

Comment: assayed together with abdomen, isoform expression analyzed

adult abdomen

Comment: assayed together with abdomen, isoform expression analyzed

Additional Descriptive Data

The expression of multiple ReepA isoforms was analyzed in adult heads and bodies.

Marker for
 
Subcellular Localization
CV Term
Polypeptide Expression
immunolocalization
Stage
Tissue/Position (including subcellular localization)
Reference
mass spectroscopy
Stage
Tissue/Position (including subcellular localization)
Reference
Additional Descriptive Data

ReepA expression is observed in endoplasmic reticulum in larval motor neurons and muscle cells.

Marker for
 
Subcellular Localization
CV Term
Evidence
References
located_in presynapse
inferred from direct assay
Expression Deduced from Reporters
Stage
Tissue/Position (including subcellular localization)
Reference
High-Throughput Expression Data
Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\ReepA in GBrowse 2
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
Images
Alleles, Insertions, Transgenic Constructs, and Aberrations
Classical and Insertion Alleles ( 12 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 11 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of ReepA
Transgenic constructs containing regulatory region of ReepA
Aberrations (Deficiencies and Duplications) ( 1 )
Inferred from experimentation ( 1 )
Gene disrupted in
Inferred from location ( 0 )
Alleles Representing Disease-Implicated Variants
Phenotypes
Orthologs
Human Orthologs (via DIOPT v8.0)
Homo sapiens (Human) (6)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Alignment
Complementation?
Transgene?
9 of 15
Yes
Yes
8 of 15
No
Yes
 
2  
8 of 15
No
Yes
7 of 15
No
Yes
2 of 15
No
No
1  
2 of 15
No
No
1  
Model Organism Orthologs (via DIOPT v8.0)
Mus musculus (laboratory mouse) (6)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Alignment
Complementation?
Transgene?
9 of 15
Yes
Yes
8 of 15
No
Yes
7 of 15
No
Yes
7 of 15
No
Yes
2 of 15
No
No
2 of 15
No
No
Rattus norvegicus (Norway rat) (6)
6 of 13
Yes
Yes
6 of 13
Yes
Yes
5 of 13
No
Yes
4 of 13
No
Yes
2 of 13
No
No
2 of 13
No
No
Xenopus tropicalis (Western clawed frog) (6)
6 of 12
Yes
Yes
6 of 12
Yes
Yes
5 of 12
No
Yes
2 of 12
No
Yes
2 of 12
No
No
2 of 12
No
No
Danio rerio (Zebrafish) (7)
9 of 15
Yes
Yes
8 of 15
No
Yes
7 of 15
No
Yes
5 of 15
No
Yes
2 of 15
No
No
2 of 15
No
No
2 of 15
No
No
Caenorhabditis elegans (Nematode, roundworm) (6)
9 of 15
Yes
Yes
3 of 15
No
No
2 of 15
No
Yes
2 of 15
No
No
2 of 15
No
No
1 of 15
No
No
Arabidopsis thaliana (thale-cress) (14)
5 of 9
Yes
Yes
5 of 9
Yes
Yes
4 of 9
No
Yes
4 of 9
No
Yes
2 of 9
No
No
2 of 9
No
No
2 of 9
No
No
2 of 9
No
No
2 of 9
No
No
2 of 9
No
No
2 of 9
No
No
1 of 9
No
Yes
1 of 9
No
Yes
1 of 9
No
Yes
Saccharomyces cerevisiae (Brewer's yeast) (1)
2 of 15
Yes
No
Schizosaccharomyces pombe (Fission yeast) (2)
4 of 12
Yes
Yes
1 of 12
No
No
Ortholog(s) in Drosophila Species (via OrthoDB v9.1) ( EOG091905AE )
Organism
Common Name
Gene
AAA Syntenic Ortholog
Multiple Dmel Genes in this Orthologous Group
Drosophila suzukii
Spotted wing Drosophila
Drosophila simulans
Drosophila sechellia
Drosophila sechellia
Drosophila erecta
Drosophila yakuba
Drosophila ananassae
Drosophila pseudoobscura pseudoobscura
Drosophila persimilis
Drosophila willistoni
Drosophila virilis
Drosophila mojavensis
Drosophila grimshawi
Drosophila grimshawi
Orthologs in non-Drosophila Dipterans (via OrthoDB v9.1) ( EOG091502DV )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Musca domestica
House fly
Glossina morsitans
Tsetse fly
Lucilia cuprina
Australian sheep blowfly
Mayetiola destructor
Hessian fly
Aedes aegypti
Yellow fever mosquito
Anopheles darlingi
American malaria mosquito
Anopheles gambiae
Malaria mosquito
Culex quinquefasciatus
Southern house mosquito
Orthologs in non-Dipteran Insects (via OrthoDB v9.1) ( EOG090W0NY2 )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Bombyx mori
Silkmoth
Danaus plexippus
Monarch butterfly
Danaus plexippus
Monarch butterfly
Heliconius melpomene
Postman butterfly
Apis florea
Little honeybee
Apis mellifera
Western honey bee
Bombus impatiens
Common eastern bumble bee
Bombus terrestris
Buff-tailed bumblebee
Linepithema humile
Argentine ant
Megachile rotundata
Alfalfa leafcutting bee
Nasonia vitripennis
Parasitic wasp
Dendroctonus ponderosae
Mountain pine beetle
Tribolium castaneum
Red flour beetle
Pediculus humanus
Human body louse
Rhodnius prolixus
Kissing bug
Cimex lectularius
Bed bug
Acyrthosiphon pisum
Pea aphid
Acyrthosiphon pisum
Pea aphid
Zootermopsis nevadensis
Nevada dampwood termite
Orthologs in non-Insect Arthropods (via OrthoDB v9.1) ( EOG090X0O7Y )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strigamia maritima
European centipede
Ixodes scapularis
Black-legged tick
Stegodyphus mimosarum
African social velvet spider
Stegodyphus mimosarum
African social velvet spider
Tetranychus urticae
Two-spotted spider mite
Daphnia pulex
Water flea
Orthologs in non-Arthropod Metazoa (via OrthoDB v9.1) ( EOG091G136P )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strongylocentrotus purpuratus
Purple sea urchin
Strongylocentrotus purpuratus
Purple sea urchin
Paralogs
Paralogs (via DIOPT v8.0)
Drosophila melanogaster (Fruit fly) (5)
4 of 10
3 of 10
3 of 10
3 of 10
1 of 10
Human Disease Associations
FlyBase Human Disease Model Reports
Disease Model Summary Ribbon
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 1 )
Allele
Disease
Evidence
References
Potential Models Based on Orthology ( 3 )
Modifiers Based on Experimental Evidence ( 4 )
Disease Associations of Human Orthologs (via DIOPT v8.0 and OMIM)
Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
Functional Complementation Data
Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
Dmel gene
Ortholog showing functional complementation
Supporting References
Interactions
Summary of Physical Interactions
Summary of Genetic Interactions
esyN Network Diagram
esyN Network Key:
Suppression
Enhancement

Please look at the allele data for full details of the genetic interactions
Starting gene(s)
Interaction type
Interacting gene(s)
Reference
Starting gene(s)
Interaction type
Interacting gene(s)
Reference
External Data
Linkouts
DroID - A comprehensive database of gene and protein interactions.
MIST (protein-protein) - An integrated Molecular Interaction Database
Pathways
Signaling Pathways (FlyBase)
Metabolic Pathways
External Data
Linkouts
Genomic Location and Detailed Mapping Data
Chromosome (arm)
2R
Recombination map
2-101
Cytogenetic map
Sequence location
FlyBase Computed Cytological Location
Cytogenetic map
Evidence for location
59B6-59B6
Limits computationally determined from genome sequence between P{PZ}Nup21410444 and P{PZ}l(2)0649606496&P{lacW}l(2)k09913k09913
Experimentally Determined Cytological Location
Cytogenetic map
Notes
References
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Stocks and Reagents
Stocks (17)
Genomic Clones (20)
cDNA Clones (141)
 

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequenced
BDGP DGC clones
Drosophila Genomics Resource Center cDNA clones

For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

cDNA Clones, End Sequenced (ESTs)
RNAi and Array Information
Linkouts
DRSC - Results frm RNAi screens
GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
Antibody Information
Laboratory Generated Antibodies
 
Commercially Available Antibodies
 
Other Information
Relationship to Other Genes
Source for database identify of

Source for identity of: Reep1 CG42678

Source for identity of: ReepA Reep1

Source for database merge of

Source for merge of: CG30190 CG30193

Source for merge of: CG30193 BcDNA:RE29641

Source for merge of: CG30193 anon-WO0118547.113

Source for merge of: CG30193 BcDNA:LD42159

Additional comments

FlyBase curator comment: Renamed Reep1 to ReepA due to orthology to four mammalian genes (REEP1-REEP4), rather than solely REEP1.

Annotations CG30190 and CG30193 merged as CG42678 in release 5.25 of the genome annotation.

Source for merge of CG30193 BcDNA:RE29641 was a shared cDNA ( date:030728 ).

Source for merge of CG30193 anon-WO0118547.113 was sequence comparison ( date:051113 ).

Source for merge of CG30193 BcDNA:LD42159 was a shared cDNA ( date:030728 ).

Other Comments

Area matching Drosophila ESTs AA201303 and AA541066.

Origin and Etymology
Discoverer
Etymology

The gene is named 'ReepA' due to orthology to four mammalian REEP genes (REEP1-REEP4).

Identification
External Crossreferences and Linkouts ( 101 )
Sequence Crossreferences
NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information
Other crossreferences
BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones
DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
FlyMine - An integrated database for Drosophila genomics
GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
InterPro - A database of protein families, domains and functional sites
KEGG Genes - Molecular building blocks of life in the genomic space.
MARRVEL_MODEL - MARRVEL (model organism gene)
modMine - A data warehouse for the modENCODE project
Linkouts
DroID - A comprehensive database of gene and protein interactions.
DRSC - Results frm RNAi screens
MIST (protein-protein) - An integrated Molecular Interaction Database
Synonyms and Secondary IDs (15)
Datasets (0)
Study focus (0)
Experimental Role
Project
Project Type
Title
References (49)