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Gene Dmel\CG42684

General Information
Symbol	Dmel\CG42684	Species	D. melanogaster
Name		Annotation symbol	CG42684
Feature type	protein_coding_gene	FlyBase ID	FBgn0261570
Gene Model Status	Current	Stock availability	17 publicly available
Also Known As	CG32560, CG42270, CG5960, CG15816
Genomic Location
Chromosome (arm)	X	Recombination map
Cytogenetic map	16C5-16C8	Sequence location	X:17,604,178..17,645,718 [+]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents modENCODE GBrowse	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	This gene is referred to in FlyBase by the symbol Dmel\CG42684 (FBgn0261570). It is a protein_coding_gene from Drosophila melanogaster. Based on sequence similarity, it is predicted to have molecular function: Ras GTPase activator activity. There is experimental evidence that it is involved in the biological process: inter-male aggressive behavior. 30 alleles are reported. No phenotypic data is available. It has 5 annotated transcripts and 5 annotated polypeptides. Protein features are: C2 calcium-dependent membrane targeting; C2 calcium/lipid-binding domain, CaLB; Pleckstrin homology domain; Protein of unknown function DUF3498; Ras GTPase-activating protein; Ras GTPase-activating protein, conserved site; Rho GTPase activation protein. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of moderate expression. Peak expression observed within 06-12 hour embryonic stages. Summary of FlyAtlas Anatomical Expression Data: Two or more Affy2 ProbeSets identify exons of this gene. This is a summary of the tissue expression peaks exhibited in at least one of these ProbeSets. Expression at moderate levels in the following post-embryonic organs or tissues: larval/adult central nervous system, adult crop, larval/adult hindgut, larval trachea, adult ovary. Gene sequence location is X:17604178..17645718.
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2011_10	References Knowles-Barley, 2011.8.24, BrainTrap expression curation.
FB2012_01	References Reis et al., 2010, PLoS Genet. 6(11): e1001206 Carreira et al., 2011, BMC Dev. Biol. 11: 32 Sequence features BKN30101 HFA19964 BKN30384 HFA19202 BKN20916 HFA19967 HFA19731
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 16C5-16C8   Limits computationally determined from genome sequence between P{EP}EP1464 and P{EP}EP970
Experimentally Determined Cytological Location
Cytogenetic map Notes References
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\CG42684 for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
	Gene merge based on EST/cDNA data Gene merge based on EST/cDNA data.
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) CG42684-RA FBtr0302833  NM_001201733   7324   2009 CG42684-RB FBtr0302834  NM_133012   6000   1556 CG42684-RC FBtr0302835  NM_001103542   6072   1580 CG42684-RD FBtr0302836  NM_167576   5361   1583 CG42684-RE FBtr0302837  NM_001201734   6099   1589
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein CG42684-PA   FBpp0291973   218.7   2009   8.70     NP_001188662   ADV37744 CG42684-PB   FBpp0291974   170.8   1556   8.19     NP_573240   AAF48759 CG42684-PC   FBpp0291975   173.5   1580   8.13     NP_001097012   ABW09442 CG42684-PD   FBpp0291976   173.3   1583   8.97     NP_728095   AAN09593 CG42684-PE   FBpp0291977   174.5   1589   8.19     NP_001188663   ADV37745
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • C2 calcium-dependent membrane targeting (IPR000008) Pleckstrin homology domain (IPR001849) Ras GTPase-activating protein (IPR001936) Rho GTPase activation protein (IPR008936) C2 calcium/lipid-binding domain, CaLB (IPR008973) Ras GTPase-activating protein, conserved site (IPR023152) Protein of unknown function DUF3498 (IPR021887)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA697498   AE014298 AAF48759   AE014298 AAN09593   AE014298 ABW09442   AE014298 ADV37744   AE014298 ADV37745   AI517910   AW943636   AY058706 AAL13935   AY089290 AAL90028   BF499910   BF506113   BH146119   BH809405   BH809419   BI173389   BP559531   BP559532   BT120111   CK660770   CK661843   CK662412   CL868541   CO154753   CO186536   CO266916   CO280389   CO293139   CO295260   CO299295   CO299605   CO302143   CO303828   CO305379   CO308014   CO309129   CO311591   CO320605   CO325893   CO326650   CO337299   CO340286   CO341042   CO343874   CZ466283   CZ467101   CZ471422   CZ471766   CZ474311   CZ475342   CZ477200   CZ477345   CZ487040   CZ488467   EC054351   EC063726   EC063762   EC075622   EC084553   EC084775   EC089276   EC203415   EC203698   EC217672   EC222652   EC222998   EC236805   EC249665   EC254133   EC255024   EC255824   EC256854   EC257168   EC257910   EC264672   EC266101   EV592201
UniProtKB/Swiss-Prot	Q8T498
UniProtKB/TrEMBL	Q9VX22 Q8IQZ6
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
Polypeptide Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
High-Throughput Expression Data
or
See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes. modENCODE Temporal Expression Data for FBgn0261570    Styles Linear Logarithmic Heatmap    Scales max expr for FBgn0261570 Very low expression bin max Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of moderate expression. Peak expression observed within 06-12 hour embryonic stages. [download data (TSV)] Guide to modENCODE expression level colors   No expression (0 - 0)   Extremely low expression (1 - 10)   Very low expression (11 - 100)   Low expression (101 - 400)   Moderate expression (401 - 1400)   Moderately high expression (1401 - 4000)   High expression (4001 - 10000)   Very high expression (10001 - 100000)   Extremely high expression (100001 - 2000000) Linear, scaled to maximum FBgn0261570 expression level Developmental Stage   Expression Level embryo 00-02hr    3093 embryo 02-04hr    1911 embryo 04-06hr    3812 embryo 06-08hr    4968 embryo 08-10hr    3118 embryo 10-12hr    2094 embryo 12-14hr    2050 embryo 14-16hr    2680 embryo 16-18hr    1504 embryo 18-20hr    1742 embryo 20-22hr    1381 embryo 22-24hr    1246 larva L1    796 larva L2    627 larva L3 12hr old    411 larva L3 puffstage 1-2    426 larva L3 puffstage 3-6    784 larva L3 puffstage 7-9    806 white prepupae new    1381 white prepupae 12hr    1986 white prepupae 24hr    1564 pupae 2d postWPP    1813 pupae 3d postWPP    895 pupae 4d postWPP    730 adult male 01day    670 adult male 05day    714 adult male 30day    638 adult female 01day    1275 adult female 05day    1559 adult female 30day    1707 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High  Linear, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (3093) embryo 02-04hr  (1911) embryo 04-06hr  (3812) embryo 06-08hr  (4968) embryo 08-10hr  (3118) embryo 10-12hr  (2094) embryo 12-14hr  (2050) embryo 14-16hr  (2680) embryo 16-18hr  (1504) embryo 18-20hr  (1742) embryo 20-22hr  (1381) embryo 22-24hr  (1246) larva L1  (796) larva L2  (627) larva L3 12hr old  (411) larva L3 puffstage 1-2  (426) larva L3 puffstage 3-6  (784) larva L3 puffstage 7-9  (806) white prepupae new  (1381) white prepupae 12hr  (1986) white prepupae 24hr  (1564) pupae 2d postWPP  (1813) pupae 3d postWPP  (895) pupae 4d postWPP  (730) adult male 01day  (670) adult male 05day  (714) adult male 30day  (638) adult female 01day  (1275) adult female 05day  (1559) adult female 30day  (1707) Expression Level Scale  None   Extremely low   Very low   Low  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (3093) embryo 02-04hr  (1911) embryo 04-06hr  (3812) embryo 06-08hr  (4968) embryo 08-10hr  (3118) embryo 10-12hr  (2094) embryo 12-14hr  (2050) embryo 14-16hr  (2680) embryo 16-18hr  1504 embryo 18-20hr  (1742) embryo 20-22hr    1381 embryo 22-24hr    1246 larva L1    796 larva L2    627 larva L3 12hr old    411 larva L3 puffstage 1-2    426 larva L3 puffstage 3-6    784 larva L3 puffstage 7-9    806 white prepupae new    1381 white prepupae 12hr  (1986) white prepupae 24hr  (1564) pupae 2d postWPP  (1813) pupae 3d postWPP    895 pupae 4d postWPP    730 adult male 01day    670 adult male 05day    714 adult male 30day    638 adult female 01day    1275 adult female 05day  (1559) adult female 30day  (1707) Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    3093 embryo 02-04hr    1911 embryo 04-06hr    3812 embryo 06-08hr    4968 embryo 08-10hr    3118 embryo 10-12hr    2094 embryo 12-14hr    2050 embryo 14-16hr    2680 embryo 16-18hr    1504 embryo 18-20hr    1742 embryo 20-22hr    1381 embryo 22-24hr    1246 larva L1    796 larva L2    627 larva L3 12hr old    411 larva L3 puffstage 1-2    426 larva L3 puffstage 3-6    784 larva L3 puffstage 7-9    806 white prepupae new    1381 white prepupae 12hr    1986 white prepupae 24hr    1564 pupae 2d postWPP    1813 pupae 3d postWPP    895 pupae 4d postWPP    730 adult male 01day    670 adult male 05day    714 adult male 30day    638 adult female 01day    1275 adult female 05day    1559 adult female 30day    1707 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    3093 embryo 02-04hr    1911 embryo 04-06hr    3812 embryo 06-08hr    4968 embryo 08-10hr    3118 embryo 10-12hr    2094 embryo 12-14hr    2050 embryo 14-16hr    2680 embryo 16-18hr    1504 embryo 18-20hr    1742 embryo 20-22hr    1381 embryo 22-24hr    1246 larva L1    796 larva L2    627 larva L3 12hr old    411 larva L3 puffstage 1-2    426 larva L3 puffstage 3-6    784 larva L3 puffstage 7-9    806 white prepupae new    1381 white prepupae 12hr    1986 white prepupae 24hr    1564 pupae 2d postWPP    1813 pupae 3d postWPP    895 pupae 4d postWPP    730 adult male 01day    670 adult male 05day    714 adult male 30day    638 adult female 01day    1275 adult female 05day    1559 adult female 30day    1707 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  log, scaled to maximum FBgn0261570 expression level Developmental Stage   Expression Level embryo 00-02hr    3093 embryo 02-04hr    1911 embryo 04-06hr    3812 embryo 06-08hr    4968 embryo 08-10hr    3118 embryo 10-12hr    2094 embryo 12-14hr    2050 embryo 14-16hr    2680 embryo 16-18hr    1504 embryo 18-20hr    1742 embryo 20-22hr    1381 embryo 22-24hr    1246 larva L1    796 larva L2    627 larva L3 12hr old    411 larva L3 puffstage 1-2    426 larva L3 puffstage 3-6    784 larva L3 puffstage 7-9    806 white prepupae new    1381 white prepupae 12hr    1986 white prepupae 24hr    1564 pupae 2d postWPP    1813 pupae 3d postWPP    895 pupae 4d postWPP    730 adult male 01day    670 adult male 05day    714 adult male 30day    638 adult female 01day    1275 adult female 05day    1559 adult female 30day    1707 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (3093) embryo 02-04hr  (1911) embryo 04-06hr  (3812) embryo 06-08hr  (4968) embryo 08-10hr  (3118) embryo 10-12hr  (2094) embryo 12-14hr  (2050) embryo 14-16hr  (2680) embryo 16-18hr  (1504) embryo 18-20hr  (1742) embryo 20-22hr  (1381) embryo 22-24hr  (1246) larva L1  (796) larva L2  (627) larva L3 12hr old  (411) larva L3 puffstage 1-2  (426) larva L3 puffstage 3-6  (784) larva L3 puffstage 7-9  (806) white prepupae new  (1381) white prepupae 12hr  (1986) white prepupae 24hr  (1564) pupae 2d postWPP  (1813) pupae 3d postWPP  (895) pupae 4d postWPP  (730) adult male 01day  (670) adult male 05day  (714) adult male 30day  (638) adult female 01day  (1275) adult female 05day  (1559) adult female 30day  (1707) Expression Level Scale  None   Extremely low   Very low   Low  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (3093) embryo 02-04hr  1911 embryo 04-06hr  (3812) embryo 06-08hr  (4968) embryo 08-10hr  (3118) embryo 10-12hr  2094 embryo 12-14hr  2050 embryo 14-16hr  (2680) embryo 16-18hr  1504 embryo 18-20hr  1742 embryo 20-22hr    1381 embryo 22-24hr    1246 larva L1    796 larva L2    627 larva L3 12hr old    411 larva L3 puffstage 1-2    426 larva L3 puffstage 3-6    784 larva L3 puffstage 7-9    806 white prepupae new    1381 white prepupae 12hr  1986 white prepupae 24hr  1564 pupae 2d postWPP  1813 pupae 3d postWPP    895 pupae 4d postWPP    730 adult male 01day    670 adult male 05day    714 adult male 30day    638 adult female 01day    1275 adult female 05day  1559 adult female 30day  1707 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    3093 embryo 02-04hr    1911 embryo 04-06hr    3812 embryo 06-08hr    4968 embryo 08-10hr    3118 embryo 10-12hr    2094 embryo 12-14hr    2050 embryo 14-16hr    2680 embryo 16-18hr    1504 embryo 18-20hr    1742 embryo 20-22hr    1381 embryo 22-24hr    1246 larva L1    796 larva L2    627 larva L3 12hr old    411 larva L3 puffstage 1-2    426 larva L3 puffstage 3-6    784 larva L3 puffstage 7-9    806 white prepupae new    1381 white prepupae 12hr    1986 white prepupae 24hr    1564 pupae 2d postWPP    1813 pupae 3d postWPP    895 pupae 4d postWPP    730 adult male 01day    670 adult male 05day    714 adult male 30day    638 adult female 01day    1275 adult female 05day    1559 adult female 30day    1707 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    3093 embryo 02-04hr    1911 embryo 04-06hr    3812 embryo 06-08hr    4968 embryo 08-10hr    3118 embryo 10-12hr    2094 embryo 12-14hr    2050 embryo 14-16hr    2680 embryo 16-18hr    1504 embryo 18-20hr    1742 embryo 20-22hr    1381 embryo 22-24hr    1246 larva L1    796 larva L2    627 larva L3 12hr old    411 larva L3 puffstage 1-2    426 larva L3 puffstage 3-6    784 larva L3 puffstage 7-9    806 white prepupae new    1381 white prepupae 12hr    1986 white prepupae 24hr    1564 pupae 2d postWPP    1813 pupae 3d postWPP    895 pupae 4d postWPP    730 adult male 01day    670 adult male 05day    714 adult male 30day    638 adult female 01day    1275 adult female 05day    1559 adult female 30day    1707 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     FlyAtlas Anatomical Expression Data for FBgn0261570    Styles Linear Logarithmic Heatmap Back-to-back    Scales max expr for FBgn0261570 Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Two or more Affy2 ProbeSets identify exons of this gene. This is a summary of the tissue expression peaks exhibited in at least one of these ProbeSets. Expression at moderate levels in the following post-embryonic organs or tissues: larval/adult central nervous system, adult crop, larval/adult hindgut, larval trachea, adult ovary. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (1000 - 25000) Heatmap Tissue   Expression Level Larval Central Nervous System no informative data Larval Midgut no informative data Larval Hindgut no informative data Larval Malpighian Tubules no informative data Larval Fat Body no informative data Larval Salivary Gland no informative data Larval Trachea no informative data Larval Carcass no informative data Adult Head no informative data Adult Eye no informative data Adult Brain no informative data Adult Thoracic-Abdominal Ganglion no informative data Adult Crop no informative data Adult Midgut no informative data Adult Hindgut no informative data Adult Malpighian Tubules no informative data Adult Fat Body no informative data Adult Salivary Gland no informative data Adult Heart no informative data Adult VirginFemale Spermatheca no informative data Adult InseminatedFemale Spermatheca no informative data Adult Ovary no informative data Adult Testis no informative data Adult Male Accessory Gland no informative data Adult Carcass no informative data modENCODE Temporal Expression Data (Graveley et al., 2011) FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
Expression Clusters
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0030866
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele viable CG42684BG02522 CG42684CA06772 CG42684EY12035 CG42684EY14562 viable, with Scer\GAL4pnr-MD237 CG42684GD9127 CG42684GD9889 CG42684GD13505 Sterility Allele fertile CG42684EY12035 CG42684EY14562 Other Phenotypes Allele behavior defective | recessive CG42684BG02522 smell perception defective CG42684BG02522 Phenotype manifest in Allele
Classical Alleles ( 26 )
For All Classical Alleles Show
Allele of CG42684 Class Mutagen Stocks Known lesion CG42684BG02522 P-element activity 1 -- CG42684d00162 P-element activity 1 -- CG42684d00724 P-element activity 1 -- CG42684d06773 P-element activity 1 -- CG42684EY12035 P-element activity 1 -- CG42684EY14562 P-element activity 1 -- CG42684f04504 piggyBac transposase 1 -- CG42684f05842 piggyBac transposase 1 -- CG42684f07383 1 -- CG42684KG01288 1 -- CG42684KG01795 P-element activity 1 -- CG42684KG02464 P-element activity 1 -- CG42684KG05436 1 -- CG426845-HA-2636 0 -- CG42684BG01568a P-element activity 0 -- CG42684c00219 piggyBac transposase 0 -- CG42684c01362 piggyBac transposase 0 -- CG42684CA06772 P-element activity 0 Yes CG42684CB-0079-3 0 -- CG42684CPTI001341 piggyBac transposase 0 Yes CG42684d05083 P-element activity 0 -- CG42684d10298 P-element activity 0 -- CG42684d10609 P-element activity 0 -- CG42684GG01470 0 -- CG42684GG01552 0 -- CG42684GG01604 0 --
Alleles Carried on Transgenic Constructs ( 4 )
For All Alleles Carried on Transgenic Constructs Show
Allele of CG42684 Class Mutagen Stocks Known lesion CG42684GD9889 in vitro construct - RNAi in vitro construct - regulatory fusion 2 Yes CG42684GD13505 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes CG42684GD9127 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes CG42684KK110101 in vitro construct - RNAi in vitro construct - regulatory fusion 0 Yes
Aneuploid Aberrations
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{KK110101} NA
Insertions
	Type of insertions Name Expression data miscellaneous insertions P{GT1}CG42684BG01568a NA P{GT1}CG42684BG02522 NA P{PTT-GA}CG42684CA06772 NA P{RS3}CG42684CB-0079-3 NA P{RS5}CG426845-HA-2636 NA P{SUPor-P}CG42684KG01288 NA P{SUPor-P}CG42684KG01795 NA P{SUPor-P}CG42684KG02464 NA P{SUPor-P}CG42684KG05436 NA PBac{681.P.FSVS-1}CG42684CPTI001341 NA PBac{PB}CG42684c00219 NA PBac{PB}CG42684c01362 NA PBac{WH}CG42684f04504 NA PBac{WH}CG42684f05842 NA PBac{WH}CG42684f07383 NA insertion of mobile activating element P{EPgy2}CG42684EY12035 NA P{EPgy2}CG42684EY14562 NA P{Mae-UAS.6.11}CG42684GG01470 NA P{Mae-UAS.6.11}CG42684GG01552 NA P{Mae-UAS.6.11}CG42684GG01604 NA P{XP}CG42684d00162 NA P{XP}CG42684d00724 NA P{XP}CG42684d05083 NA P{XP}CG42684d06773 NA P{XP}CG42684d10298 NA P{XP}CG42684d10609 NA
Gene Ontology: Function, Process & Cellular Component ( 5 unique terms )
Terms Based on Experimental Evidence ( 1 term )
Molecular Function ( 0 terms)
Biological Process
CV term Evidence References
inter-male aggressive behavior inferred from mutant phenotype (Edwards et al., 2009)
Cellular Component ( 0 terms)
Terms Based on Predictions or Assertions ( 4 terms )
Molecular Function
CV term Evidence References
Ras GTPase activator activity inferred from sequence or structural similarity with UniProtKB:Q9UAI0 (assigned by UniProtKB) (Swiss-Prot Project Members, 2003.9.15) inferred from sequence or structural similarity with UniProtKB:Q9UJF2 (FlyBase, 1992-)
Biological Process
CV term Evidence References
negative regulation of Ras protein signal transduction inferred from sequence or structural similarity with UniProtKB:Q9UAI0 (assigned by UniProtKB) (Swiss-Prot Project Members, 2003.9.15) Ras protein signal transduction inferred from sequence or structural similarity with UniProtKB:Q9UJF2 (FlyBase, 1992-)
Cellular Component
CV term Evidence References
cytoplasm inferred from sequence or structural similarity with UniProtKB:Q9UAI0 (assigned by UniProtKB) (Swiss-Prot Project Members, 2003.9.15)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Protein-protein
Interacting group Assay References
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions CG42684 allele Gene References
External Data
Linkouts	DroID - A comprehensive database of gene and protein interactions. • FBgn0261570 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 32754
Orthologs
Genome-wide drosophilid orthologs	Dana\GF19468 Dere\GG19129 Dgri\GH12821 Dmoj\GI15924 Dper\GL14748 Dpse\GA16990 Dsec\GM13523 Dsim\GD13084 Dsim\GD17363 Dvir\GJ16831 Dwil\GK25320 Dyak\GE17680 Dyak\GE17682
Curated drosophilid orthologs	Dmir\CG32560 (Thornton, 2005.12.20) Dpse\GA13967   Dpse\GA16989   Dpse\GA16990
Linkouts	OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • PB13852 NV14574 LH13410 ISCW015673 FBgn0235130 FBgn0227279 FBgn0204010 FBgn0188922 FBgn0168454 JGI_V11_31639 FBgn0077004 FBgn0152352 FBgn0138673 FBgn0120300 FBgn0111335 FBgn0096475 CPIJ013989 BGIBMGA007885 ACYPI010209 GB19097 AGAP004692 AAEL005847 PHUM297000
Stocks & Reagents
Stocks Listed in FlyBase ( 17 )
Bloomington	12700 w1118 P{GT1}CG42684BG02522 13920 y1 P{SUPor-P}CG42684KG01795
Harvard	- P{XP}CG42684d00162 - P{XP}CG42684d00724 - P{XP}CG42684d06773 - PBac{WH}CG42684f04504 - PBac{WH}CG42684f05842 - PBac{WH}CG42684f07383
VDRC	v20983 w1118; P{GD9889}v20983 v23432 w1118; P{GD13505}v23432 v19616 w1118; P{GD9127}v19616/TM3 v20984 w1118; P{GD9889}v20984/CyO
	More stocks available...
Genomic Clones ( 2 )
	BACR01N10 BACR42I14 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 54 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	AT08504 LD43050
Other clones	IP07223
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	AT14688 HL02651 LP19627 LP21591 LP22603 RE16295
Other clones	36884 40219 49909 55553 73236 73684 79231 102363 145888 153007 157291 158843 214377.34 214385.41 214409.48 214413.36 214511.41 214535.44 524085 568946 CK01.22D.E12 Dmel_neb_006863_0660_0462 EC054351 EK020752 EK147926 EK153940 EK175026 EK175924 EK183234 EK201916 EK209112 EK225515 EK242906 EK248412 EK256418 EK260361 EK286505 EN04730 EN14231 EP02852 EP04363 EP10342 EP11757 EP18254 FGM321E01
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0261570 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 32754 32755 318089
Antibody Information
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of
Source for database merge of	Source for merge of: CG5898 CG5960 (FlyBase, 1996-) Source for merge of: CG32559 CG32560 (FlyBase Genome Annotators, 2008) Source for merge of: CG42270 CG15816 (FlyBase Genome Annotators, 2010)
Additional comments	Annotations CG42270 and CG15816 merged as CG42684 in release 5.25 of the genome annotation. (FlyBase Genome Annotators, 2010) Annotations CG32559 and CG32560 merged as CG42270 in release 5.8 of the genome annotation. (FlyBase Genome Annotators, 2008) Annotations CG5898, CG5960 merged as CG32560 in release 3 of the genome annotation. (FlyBase Genome Annotators, 2002-2003) "CG15816" may correspond to "Scim5". Sequence analysis off ends of P{SUPor-P} in Scim insertion mutant places "Scim5" near/in "CG15816". (Dobie and Karpen, 2001.4.18) Source for merge of CG5898 CG5960 was a shared cDNA (date:010720). (FlyBase, 1996-)
Other Comments
	RNAi generated by PCR using primers directed to this gene causes a cell growth and viability phenotype when assayed in Kc167 and S2R+ cells. (Boutros et al., 2004) dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R+ cell morphology. (Kiger et al., 2003) New annotation (CG32559) in release 3 of the genome annotation. (FlyBase Genome Annotators, 2002-2003)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_133012 NM_167576 NM_001103542 NM_001201733 NM_001201734 RefSeq (Proteins) • NP_573240 NP_728095 NP_001097012 NP_001188662 NP_001188663 DDBJ / EMBL / GenBank • AAF48759 AAF48760 AAL13935 AAL90028 AAN09593 ABW09442 ADV37744 ADV37745 AI517910 AW943636 AY058706 AY089290 BF506113 BH146119 BH809405 BH809419 CL868541 CZ466283 CZ467101 CZ471422 CZ471766 CZ474311 CZ475342 CZ477200 CZ477345 CZ487040 CZ488467 Entrez Gene - A searchable database of RefSeq genes. • 32754 32755 UniProtKB/Swiss-Prot • Q8T498 UniProtKB/TrEMBL • Q8IQZ6 Q9VX22
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • C2 calcium-dependent membrane targeting (IPR000008) Pleckstrin homology domain (IPR001849) Ras GTPase-activating protein (IPR001936) Rho GTPase activation protein (IPR008936) C2 calcium/lipid-binding domain, CaLB (IPR008973) Ras GTPase-activating protein, conserved site (IPR023152) Protein of unknown function DUF3498 (IPR021887)
Linkouts
	DroID - A comprehensive database of gene and protein interactions. • FBgn0261570 DRSC - Results from RNAi screens. • FBgn0261570 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0030866 FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0261570 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 32754 32755 318089 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 32754 modMine - Data generated by the modENCODE project. • FBgn0261570 OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • PB13852 NV14574 LH13410 ISCW015673 FBgn0235130 FBgn0227279 FBgn0204010 FBgn0188922 FBgn0168454 JGI_V11_31639 FBgn0077004 FBgn0152352 FBgn0138673 FBgn0120300 FBgn0111335 FBgn0096475 CPIJ013989 BGIBMGA007885 ACYPI010209 GB19097 AGAP004692 AAEL005847 PHUM297000
Synonyms & Secondary IDs ( 7 )
Reported As
Symbol Synonym	CG5898   CG5960 (Huntley and Golding, 2004, Boutros et al., 2004, Bernards, 2003, ) CG15816 (Sambandan et al., 2006, Kind et al., 2008, Keleman et al., 2009.8.5) CG32559 (Kind et al., 2008) CG32560 (Buszczak et al., 2007, Kankel et al., 2007, Kind et al., 2008, Kwon et al., 2008, Morozova et al., 2007, Reis et al., 2010) CG42270 (FlyBase Genome Annotators, 2008, Edwards et al., 2009, Kong et al., 2010) CG42684 (FlyBase Genome Annotators, 2010)
Name Synonym	CG32559   CG32560
Secondary FlyBase IDs
	FBgn0030865 FBgn0030866 FBgn0030867 FBgn0052559 FBgn0052560 FBgn0259165
References ( 34 )
Generate a list of	All references relating to this gene ( 34 )
List References by type	Research paper  ( 11 ) Supplementary material  ( 4 ) Review  ( 1 ) Personal communication to FlyBase  ( 5 ) FlyBase analysis  ( 6 ) Protein sequence record  ( 1 ) Computer file  ( 3 ) DNA/RNA sequence record  ( 1 ) Automatic genome annotation  ( 1 ) Curated genome annotation  ( 1 )
Recent research papers ( 3 )
	Carreira et al., 2011, BMC Dev. Biol. 11: 32 Genetic basis of wing morphogenesis in Drosophila: sexual dimorphism and non-allometric effects of shape variation. [FBrf0214273] Kong et al., 2010, Alcoholism, Clin. Exp. Res. 34(2): 302--316 Ethanol-regulated genes that contribute to ethanol sensitivity and rapid tolerance in Drosophila. [FBrf0209720] Reis et al., 2010, PLoS Genet. 6(11): e1001206 A buoyancy-based screen of Drosophila larvae for fat-storage mutants reveals a role for sir2 in coupling fat storage to nutrient availability. [FBrf0212335] Show all research papers ...
Recent reviews (0)
	All reviews listed in FlyBase were published before 2010 Show reviews ...