FlyBase Gene Report: Dmel\CoRest

General Information

Symbol

Dmel\CoRest

Species

D. melanogaster

Name

CoRest

Annotation Symbol

CG42687

Feature Type

protein_coding_gene

FlyBase ID

FBgn0261573

Gene Model Status

Current

Stock Availability

12 publicly available

Gene Snapshot

CoRest (CoRest) encodes a DNA binding factor that controls transcription in cooperation with other transcriptional regulators. It positively modulates Notch signaling as well as showing co-repressor activity via histone modification regulation. [Date last reviewed: 2019-02-28]

Other Summaries

Alliance
Auto summary
Gene Group
UniProtKB
Interactive Fly

Also Known As

dCoREST

Key Links

Genomic Location

Cytogenetic map

18C8-18C8

Sequence location

X:19,521,929..19,530,896 [+]

Recombination map

1-62

RefSeq locus

NC_004354 REGION:19521929..19530896

Sequence

Get Decorated FASTA

Genomic Maps

JBrowse GBrowse

Help me choose

Other Genome Views

The following external sites may use different assemblies or annotations than FlyBase.

Function

GO Summary Ribbons

Gene Ontology (GO) Annotations (15 terms)

Molecular Function (4 terms)

Terms Based on Experimental Evidence (3 terms)

CV Term

Evidence

References

enables chromatin binding

inferred from direct assay

(Dallman et al., 2004)

enables protein binding

inferred from physical interaction with FLYBASE:chn; FB:FBgn0015371

(Tsuda et al., 2006)

inferred from physical interaction with FLYBASE:ttk; FB:FBgn0003870

(Dallman et al., 2004)

enables transcription corepressor activity

inferred from direct assay

(Dallman et al., 2004)

Terms Based on Predictions or Assertions (2 terms)

CV Term

Evidence

References

enables DNA binding

inferred from electronic annotation with InterPro:IPR009057

(assigned by InterPro )

(FlyBase Curators et al., 2004-)

enables transcription corepressor activity

inferred from biological aspect of ancestor with PANTHER:PTN001043031

(assigned by GO_Central )

(Gaudet et al., 2011)

Biological Process (7 terms)

Terms Based on Experimental Evidence (4 terms)

CV Term

Evidence

References

involved_in negative regulation of histone H3-K27 methylation

inferred from mutant phenotype

(Domanitskaya and Schüpbach, 2012)

involved_in negative regulation of histone H4-K16 acetylation

inferred from mutant phenotype

(Domanitskaya and Schüpbach, 2012)

involved_in negative regulation of transcription, DNA-templated

inferred from direct assay

(Dallman et al., 2004)

involved_in positive regulation of DNA methylation-dependent heterochromatin assembly

inferred from mutant phenotype

(Yu et al., 2015)

Terms Based on Predictions or Assertions (4 terms)

CV Term

Evidence

References

involved_in histone deacetylation

inferred from biological aspect of ancestor with PANTHER:PTN001043031

(assigned by GO_Central )

(Gaudet et al., 2011)

involved_in negative regulation of transcription by RNA polymerase II

inferred from sequence or structural similarity with HGNC:17441

(Dallman et al., 2004)

involved_in negative regulation of transcription, DNA-templated

inferred from biological aspect of ancestor with PANTHER:PTN001043031

(assigned by GO_Central )

(Gaudet et al., 2011)

involved_in regulation of transcription by RNA polymerase II

inferred from biological aspect of ancestor with PANTHER:PTN001043031

(assigned by GO_Central )

(Gaudet et al., 2011)

Cellular Component (4 terms)

Terms Based on Experimental Evidence (2 terms)

CV Term

Evidence

References

located_in nucleus

inferred from direct assay

(Dallman et al., 2004)

part_of transcription repressor complex

inferred from physical interaction with FLYBASE:inferred from high throughput direct assayC1; FB:FBgn0015805

(Dallman et al., 2004)

inferred from physical interaction with FLYBASE:Su(var)3-3; FB:FBgn0260397

(Dallman et al., 2004)

Terms Based on Predictions or Assertions (2 terms)

CV Term

Evidence

References

part_of histone deacetylase complex

inferred from biological aspect of ancestor with PANTHER:PTN001043031

(assigned by GO_Central )

(Gaudet et al., 2011)

part_of transcription regulator complex

inferred from biological aspect of ancestor with PANTHER:PTN001043031

(assigned by GO_Central )

(Gaudet et al., 2011)

Gene Group (FlyBase)

SANT-MYB DOMAIN TRANSCRIPTION REGULATORS

Protein Family (UniProt)

Belongs to the CoREST family. (Q59E36)

Protein Signatures (InterPro)

Summaries

Gene Group (FlyBase)

SANT-MYB DOMAIN TRANSCRIPTION REGULATORS -: The SANT-MYB domain transcription regulators are essentially part of chromatin remodelling complexes and co-repressors. The SANT domain shows similarity with DNA-binding helix-turn-helix of Myb domain, and are involved in protein-protein interactions in the chromatin complexes. (Adapted from PMID:15040448).

Protein Function (UniProtKB)

Essential component of a corepressor complex that represses transcription of neuron-specific genes in non-neuronal cells. The BHC complex is recruited by Ttk88 and probably acts by deacetylating and demethylating specific sites on histones, thereby acting as a chromatin modifier. May serve as a molecular beacon for the recruitment of molecular machinery that imposes silencing across a chromosomal interval.

(UniProt, Q59E36)

Summary (Interactive Fly)

Interactive Fly

Gene Model and Products

Number of Transcripts

Number of Unique Polypeptides

Please see the JBrowse view of Dmel\CoRest for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)

Isoform displayed:

Pfam protein domains

InterPro name

classification

start

end

Protein Domains (via SMART)

Isoform displayed:

SMART protein domains

InterPro name

classification

start

end

Comments on Gene Model

Gene model includes transcripts encoding non-overlapping portions of the full CDS.

Low-frequency RNA-Seq exon junction(s) not annotated.

Supported by strand-specific RNA-Seq data.

Gene model reviewed during 5.48

Sequence Ontology: Class of Gene

nuclear_gene

protein_coding_gene

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Assoc. CDS (aa)

CoRest-RA

FBtr0302860

NM_001014756

1839

273

CoRest-RC

FBtr0302861

NM_001014754

1800

273

CoRest-RD

FBtr0302859

NM_001014755

2085

273

CoRest-RE

FBtr0302862

NM_001014753

3290

588

CoRest-RF

FBtr0302864

NM_001014752

3296

590

CoRest-RG

FBtr0302863

NM_001201742

3998

824

CoRest-RH

FBtr0307901

NM_001258824

3155

824

CoRest-RI

FBtr0307902

NM_001258825

3255

824

CoRest-RJ

FBtr0307903

NM_001258826

2203

336

CoRest-RK

FBtr0336667

NM_001272777

1834

268

Additional Transcript Data and Comments

Reported size (kB)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kDa)

Length (aa)

Theoretical pI

RefSeq ID

GenBank

CoRest-PA

FBpp0292000

30.5

273

6.97

NP_001014756

AAF48966

CoRest-PC

FBpp0292001

30.5

273

6.97

NP_001014754

AAN09498

CoRest-PD

FBpp0291999

30.5

273

6.97

NP_001014755

AAN09497

CoRest-PE

FBpp0292002

62.5

588

5.36

NP_001014753

AAX52508

CoRest-PF

FBpp0292004

62.7

590

5.36

NP_001014752

AAX52507

CoRest-PG

FBpp0292003

87.3

824

6.42

NP_001188671

ADV37753

CoRest-PH

FBpp0300335

87.3

824

6.42

NP_001245753

AFH07465

CoRest-PI

FBpp0300336

87.3

824

6.42

NP_001245754

AFH07466

CoRest-PJ

FBpp0300337

34.4

336

4.53

NP_001245755

AFH07467

CoRest-PK

FBpp0307648

30.0

268

6.89

NP_001259706

AGB95546

Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

273 aa isoforms: CoRest-PA, CoRest-PC, CoRest-PD

824 aa isoforms: CoRest-PG, CoRest-PH, CoRest-PI

Additional Polypeptide Data and Comments

Reported size (kDa)

Comments

External Data

Subunit Structure (UniProtKB)

Component of a complex that contains at least Rpd3, CoRest and Su(var)3-3/Hdm. Interacts with neuronal repressor ttk/Ttk88.

(UniProt, Q59E36)

Crossreferences

InterPro - A database of protein families, domains and functional sites

Linkouts

Sequences Consistent with the Gene Model

Nucleotide / Polypeptide Records

UniProt

Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\CoRest using the Feature Mapper tool.

External Data

Crossreferences

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

Linkouts

Expression Data

Expression Summary Ribbons

Colored tiles in ribbon indicate that expression data has been curated by FlyBase for that anatomical location. Colorless tiles indicate that there is no curated data for that location.

For complete stage-specific expression data, view the modENCODE Development RNA-Seq section under High-Throughput Expression below.

Transcript Expression

in situ

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage 1 -- 3

organism

Comment: maternally deposited

(Fisher et al., 2012)

embryonic stage 4 -- 6

organism | ubiquitous

(Fisher et al., 2012)

embryonic stage 7 -- 8

organism | ubiquitous

(Fisher et al., 2012)

embryonic stage 9 -- 10

organism | ubiquitous

(Fisher et al., 2012)

embryonic stage 11 -- 12

organism | ubiquitous

(Fisher et al., 2012)

embryonic stage 13 -- 16

organism | ubiquitous

(Fisher et al., 2012)

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Polypeptide Expression

immunolocalization

Stage

Tissue/Position (including subcellular localization)

Reference

adult stage | female & oogenesis

follicle cell

(Domanitskaya and Schüpbach, 2012)

female germline cell

(Domanitskaya and Schüpbach, 2012)

mass spectroscopy

Stage

Tissue/Position (including subcellular localization)

Reference

day 5 of adulthood & male -- day 7 of adulthood & male

spermatozoon

(Wasbrough et al., 2010)

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Evidence

References

located_in nucleus

inferred from direct assay

(Dallman et al., 2004)

part_of transcription repressor complex

inferred from physical interaction with FLYBASE:inferred from high throughput direct assayC1; FB:FBgn0015805

(Dallman et al., 2004)

inferred from physical interaction with FLYBASE:Su(var)3-3; FB:FBgn0260397

(Dallman et al., 2004)

Expression Deduced from Reporters

High-Throughput Expression Data

Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\CoRest in GBrowse 2

RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region

View exonic expression by developmental stage for Dmel\CoRest

View exonic expression by tissue for Dmel\CoRest

Bulk Downloads

RNA-Seq RPKM values for all genes

Reference

See Gelbart and Emmert, 2013 for analysis details and data files for all genes.

Developmental Proteome: Life Cycle

Developmental Proteome: Embryogenesis

External Data and Images

Linkouts

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0261573

FLIGHT - Cell culture data for RNAi and other high-throughput technologies

FBgn0052534

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG33525

Images

FlyBase Wiki

Image Based Resources

Alleles, Insertions, and Transgenic Constructs

Classical and Insertion Alleles ( 5 )

For All Classical and Insertion Alleles Show

Other relevant insertions

Transgenic Constructs ( 12 )

For All Alleles Carried on Transgenic Constructs Show

Transgenic constructs containing/affecting coding region of CoRest

Transgenic constructs containing regulatory region of CoRest

Deletions and Duplications ( 2 )

Duplicated in

Dp(1;Y)BSC134

(Domanitskaya and Schüpbach, 2012)

Dp(1;Y)BSC135

(Domanitskaya and Schüpbach, 2012)

Phenotypes

For more details about a specific phenotype click on the relevant allele symbol.

Lethality

Allele

viable

viable, with Dcr-2^UAS.cDa, Scer\GAL4^elav.PLu

viable, with Scer\GAL4^Mef2.PR

viable, with Scer\GAL4^pnr-MD237

Sterility

Allele

fertile

Other Phenotypes

Allele

visible, with Scer\GAL4^Bx-MS1096

CoRest^HM04053

visible, with Scer\GAL4^pnr-MD237

CoRest^GD15897

visible | adult stage, with Scer\GAL4^GMR.PF

CoRest^HM04053

Phenotype manifest in

Allele

eye, with Scer\GAL4^GMR.PF

CoRest^HM04053

follicle cell | somatic clone

CoRest^GF60

mesothoracic tergum, with Scer\GAL4^pnr-MD237

CoRest^GD15897

wing, with Scer\GAL4^Bx-MS1096

CoRest^HM04053

wing vein | ectopic, with Scer\GAL4^Bx-MS1096

CoRest^HM04053

Orthologs

Downloads

Download All DIOPT Orthologs

Download All OrthoDB Orthologs

Human Orthologs (via DIOPT v8.0)

Homo sapiens (Human) (10)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Hsap\RCOR1

11 of 15

Yes

Hsap\RCOR2

11 of 15

Yes

Hsap\RCOR3

10 of 15

Yes

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

Model Organism Orthologs (via DIOPT v8.0)

Mus musculus (laboratory mouse) (8)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Mmus\Rcor1

12 of 15

Yes

Mmus\Rcor2

11 of 15

Yes

Mmus\Rcor3

10 of 15

Yes

2 of 15

1 of 15

1 of 15

1 of 15

1 of 15

Rattus norvegicus (Norway rat) (12)

Rnor\LOC102552640

9 of 13

Yes

Rnor\Rcor3

8 of 13

Yes

Rnor\Rcor1

7 of 13

Yes

Rnor\Rcor2

3 of 13

Yes

Rnor\Elmsan1

2 of 13

Rnor\LOC102551140

2 of 13

Yes

2 of 13

2 of 13

1 of 13

1 of 13

Yes

Rnor\Trerf1

1 of 13

Rnor\Zfp541

1 of 13

Xenopus tropicalis (Western clawed frog) (8)

Xtro\rcor1

11 of 12

Yes

Xtro\rcor2

11 of 12

Yes

Xtro\rcor3

7 of 12

Yes

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

Danio rerio (Zebrafish) (12)

Drer\rcor1

11 of 15

Yes

Drer\rcor2

11 of 15

Yes

Drer\rcor3

10 of 15

Yes

2 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

Caenorhabditis elegans (Nematode, roundworm) (8)

Cele\spr-1

11 of 15

Yes

Cele\rcor-1

10 of 15

Yes

Cele\F28F8.7

2 of 15

Yes

Cele\Y73B3A.13

2 of 15

Yes

Cele\Y105C5A.1

2 of 15

Yes

Cele\F10E7.11

1 of 15

Cele\saeg-1

1 of 15

Cele\T07F8.4

1 of 15

Arabidopsis thaliana (thale-cress) (0)

No records found.

Saccharomyces cerevisiae (Brewer's yeast) (1)

Scer\SNT1

1 of 15

Yes

Schizosaccharomyces pombe (Fission yeast) (0)

No records found.

Ortholog(s) in Drosophila Species (via OrthoDB v9.1) ( EOG091907AQ )

Organism

Common Name

Gene

AAA Syntenic Ortholog

Multiple Dmel Genes in this Orthologous Group

Drosophila suzukii

Spotted wing Drosophila

Drosophila simulans

Drosophila sechellia

Drosophila erecta

Drosophila yakuba

Drosophila ananassae

Drosophila pseudoobscura pseudoobscura

Dpse\GA22699

Drosophila persimilis

Dper\GL14535

Drosophila willistoni

Dwil\GK25833

Drosophila virilis

Dvir\GJ15743

Drosophila mojavensis

Dmoj\GI16095

Drosophila grimshawi

Dgri\GH17657

Orthologs in non-Drosophila Dipterans (via OrthoDB v9.1) ( EOG091504HE )

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Musca domestica

House fly

Mdoa\17009135

Glossina morsitans

Tsetse fly

Gmor\GMOY004766

Lucilia cuprina

Australian sheep blowfly

Lcup\FF38_01107

Lucilia cuprina

Australian sheep blowfly

Lcup\FF38_05301

Mayetiola destructor

Hessian fly

Mdes\Mdes007322

Aedes aegypti

Yellow fever mosquito

Aaeg\AAEL001126

Anopheles darlingi

American malaria mosquito

Adar\ADAC004775

Anopheles gambiae

Malaria mosquito

Agam\AGAP002488

Culex quinquefasciatus

Southern house mosquito

Cqui\CPIJ009982

Orthologs in non-Dipteran Insects (via OrthoDB v9.1) ( EOG090W04B4 )

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Bombyx mori

Silkmoth

Bmor\BGIBMGA008364

Danaus plexippus

Monarch butterfly

Dple\DPOGS211367-PA

Heliconius melpomene

Postman butterfly

Hmel\HMEL002792

Apis florea

Little honeybee

Aflo\2664494068

Apis mellifera

Western honey bee

Amel\GB52614

Bombus impatiens

Common eastern bumble bee

Bimp\BIMP12022

Bombus terrestris

Buff-tailed bumblebee

Bter\15213588

Linepithema humile

Argentine ant

Lhum\LH24381

Megachile rotundata

Alfalfa leafcutting bee

Mrot\MROTU:00251f

Nasonia vitripennis

Parasitic wasp

Nvit\Nasvi2EG021063

Tribolium castaneum

Red flour beetle

Tcas\GLEAN_07336

Pediculus humanus

Human body louse

Phum\PHUM256790

Rhodnius prolixus

Kissing bug

Rpro\RPRC007001

Cimex lectularius

Bed bug

Clec\CLEC002819

Acyrthosiphon pisum

Pea aphid

Apim\ACYPI004445

Acyrthosiphon pisum

Pea aphid

Apim\ACYPI24793

Zootermopsis nevadensis

Nevada dampwood termite

Znev\Znev_02708

Orthologs in non-Insect Arthropods (via OrthoDB v9.1) ( EOG090X04QV )

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Strigamia maritima

European centipede

Smar\SMAR003351

Ixodes scapularis

Black-legged tick

Isca\ISCW012950

Ixodes scapularis

Black-legged tick

Isca\ISCW007037

Stegodyphus mimosarum

African social velvet spider

Smim\KFM70515.1

Tetranychus urticae

Two-spotted spider mite

Turt\tetur37g00390

Daphnia pulex

Water flea

Dpux\DAPPUDRAFT_248217

Orthologs in non-Arthropod Metazoa (via OrthoDB v9.1) ( EOG091G096Y )

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Strongylocentrotus purpuratus

Purple sea urchin

Spur\SPU_017381gn

Strongylocentrotus purpuratus

Purple sea urchin

Spur\Sp-Rcor3

Ciona intestinalis

Vase tunicate

Cint\ENSCING00000023994

Gallus gallus

Domestic chicken

Ggal\RCOR1

Gallus gallus

Domestic chicken

Ggal\ENSGALG00000009871

Paralogs

Downloads

Download All DIOPT Paralogs

Paralogs (via DIOPT v8.0)

Drosophila melanogaster (Fruit fly) (3)

Gene Symbol

Score

Source

Alignment

3 of 10

3 of 10

1 of 10

Human Disease Associations

FlyBase Human Disease Model Reports

Disease Model Summary Ribbon

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Allele

Disease

Evidence

References

Potential Models Based on Orthology ( 0 )

Human Ortholog

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Allele

Disease

Interaction

References

Disease Associations of Human Orthologs (via DIOPT v8.0 and OMIM)

Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.

Homo sapiens (Human)

Gene name

Score

OMIM

OMIM Phenotype

DO term

Complementation?

Transgene?

RCOR1; REST corepressor 1

11 of 15

607675

RCOR2; REST corepressor 2

11 of 15

616019

RCOR3; REST corepressor 3

10 of 15

Functional Complementation Data

Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.

Interactions

Summary of Physical Interactions

esyN Network Diagram

Interactions Browser

View in Interactions Browser

Please see the Physical Interaction reports below for full details

protein-protein

Physical Interaction

Assay

References

CoRest - G9a

anti tag coimmunoprecipitation, western blot, molecular sieving, anti bait coimmunoprecipitation, Identification by mass spectrometry

(Mačinković et al., 2019)

CoRest - HDAC1

anti bait coimmunoprecipitation, Identification by mass spectrometry, molecular sieving, anti tag coimmunoprecipitation, western blot, experimental knowledge based

(Mačinković et al., 2019, Guruharsha et al., 2011)

CoRest - Lint-1

anti tag coimmunoprecipitation, western blot, anti bait coimmunoprecipitation, Identification by mass spectrometry, affinity technology, peptide massfingerprinting, molecular sieving, ion exchange chromatography, experimental knowledge based

(Mačinković et al., 2019, Meier et al., 2012, Guruharsha et al., 2011)

CoRest - Scm

tandem affinity purification, Identification by mass spectrometry

(Kang et al., 2015)

CoRest - Su(var)3-3

anti tag coimmunoprecipitation, western blot, molecular sieving, ion exchange chromatography, anti bait coimmunoprecipitation, Identification by mass spectrometry

(Mačinković et al., 2019, Meier et al., 2012)

CoRest - Ubx

bimolecular fluorescence complementation, fluorescence microscopy

(Bischof et al., 2018)

CoRest - abd-A

bimolecular fluorescence complementation, fluorescence microscopy

(Bischof et al., 2018)

CoRest - chn

anti tag coimmunoprecipitation, anti tag western blot

(Tsuda et al., 2006)

CoRest - l(3)mbt

anti tag coimmunoprecipitation, western blot, molecular sieving, ion exchange chromatography, anti bait coimmunoprecipitation, Identification by mass spectrometry

(Mačinković et al., 2019, Meier et al., 2012)

CoRest - stumps

two hybrid

(Battersby et al., 2003)

Summary of Genetic Interactions

esyN Network Diagram

esyN Network Key:

Suppression

Enhancement

View in Interactions Browser

Please look at the allele data for full details of the genetic interactions

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

enhanceable

CoRest

(Domanitskaya and Schüpbach, 2012)

Ras85D

suppressible

CoRest

(Friedman et al., 2011)

External Data

Subunit Structure (UniProtKB)

Component of a complex that contains at least Rpd3, CoRest and Su(var)3-3/Hdm. Interacts with neuronal repressor ttk/Ttk88.

(UniProt, Q59E36 )

Linkouts

DroID - A comprehensive database of gene and protein interactions.

FBgn0261573

InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.

32941

MIST (protein-protein) - An integrated Molecular Interaction Database

CoRest

Pathways

Signaling Pathways (FlyBase)

Metabolic Pathways

External Data

Linkouts

Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.

Factors involved in megakaryocyte development and platelet production

Genomic Location and Detailed Mapping Data

Chromosome (arm)

Recombination map

1-62

Cytogenetic map

18C8-18C8

Sequence location

X:19,521,929..19,530,896 [+]

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

18C8-18C8

Limits computationally determined from genome sequence between P{EP}EP1526&P{EP}Pfrx^EP1150 and P{EP}Tao-1^EP1455

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

Experimentally Determined Recombination Data

Location

1-62

(FlyBase, 2016)

1-62.1

(Comeron et al., 2012)

Left of (cM)

Right of (cM)

(Domanitskaya and Schüpbach, 2012)

Notes

Stocks and Reagents

Stocks (12)

Bloomington

31743

y¹ v¹; P{TRiP.HM04053}attP2

51221

y¹ w^* Mi{MIC}CoRest^MI08173

67386

y¹ w^*; PBac{CoRest-GFP.FPTB}VK00033

20793

y¹ w^67c23 P{EPgy2}CoRest^EY14216

52219

y¹ w^* CoRest^GF60 P{neoFRT}19A/FM7c, P{GAL4-Kr.C}DC1, P{UAS-GFP.S65T}DC5, sn⁺

FlyORF

F003270

M{UAS-CoRest.ORF-CC}ZH-21F

F000664

M{UAS-CoRest.ORF.3xHA.GW}ZH-86Fb

F004874

M{UAS-CoRest.ORF-VNshort}ZH-86Fb

VDRC

v102566

P{KK112017}VIE-260B

v104900

P{KK111943}VIE-260B

v34179

w¹¹¹⁸; P{GD10500}v34179

v34180

w¹¹¹⁸; P{GD10500}v34180

Genomic Clones (21)

Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

cDNA Clones (132)

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequenced

BDGP DGC clones

Other clones

Drosophila Genomics Resource Center cDNA clones

For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

FBgn0261573

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

Other clones

RNAi and Array Information

Linkouts

DRSC - Results frm RNAi screens

FBgn0261573

GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents

32941

Antibody Information

Laboratory Generated Antibodies

Commercially Available Antibodies

Other Information

Relationship to Other Genes

Source for database identify of

Source for identity of: CoRest CG33525

(Dallman et al., 2004)

Source for database merge of

Source for merge of: CG3878 CG32535

(Dallman, 2004.6.23)

Source for merge of: CoRest CG32534

(FlyBase Genome Annotators, 2010)

Source for merge of: CG32535 BcDNA:GH01486

(FlyBase, 1996-)

Source for merge of: CG3878 BcDNA:LD11215

(FlyBase, 1996-)

Additional comments

Annotations CG33525 and CG32534 merged as CG42687 in release 5.25 of the genome annotation.

(FlyBase Genome Annotators, 2010)

Annotations CG3878 and CG32535 merged as CG33525 in release 4.1 of the genome annotation.

(FlyBase Genome Annotators, 2005)

Source for merge of CG32535 BcDNA:GH01486 was a shared cDNA ( date:030728 ).

(FlyBase, 1996-)

Source for merge of CG3878 BcDNA:LD11215 was a shared cDNA ( date:020730 ).

(FlyBase, 1996-)

Other Comments

CoRest positively regulates N signaling, acting downstream of the proteolytic cleavage of the N protein, but upstream of peb activity.

(Domanitskaya and Schüpbach, 2012)

New annotation (CG32535) in release 3 of the genome annotation.

(FlyBase Genome Annotators, 2002-2003)

New annotation (CG32534) in release 3 of the genome annotation.

(FlyBase Genome Annotators, 2002-2003)

Origin and Etymology

Discoverer

Etymology

Identification

As a putative ortholog for mammalian "CoREST" due to DNA sequence similarity.

(Dallman et al., 2004)

External Crossreferences and Linkouts ( 72 )

Sequence Crossreferences

NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.

32941

GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.

GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.

RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.

UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information

Q59E36

UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information

Other crossreferences

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0261573

Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones

FBgn0261573

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG33525

FlyMine - An integrated database for Drosophila genomics

FBgn0261573

GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents

32941

iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)

TC007336

InterPro - A database of protein families, domains and functional sites

KEGG Genes - Molecular building blocks of life in the genomic space.

Dmel_CG42687

modMine - A data warehouse for the modENCODE project

FBgn0261573

Linkouts

DroID - A comprehensive database of gene and protein interactions.

FBgn0261573

DRSC - Results frm RNAi screens

FBgn0261573

FLIGHT - Cell culture data for RNAi and other high-throughput technologies

FBgn0052534

Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution

Interactive Fly

InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.

32941

MIST (protein-protein) - An integrated Molecular Interaction Database

CoRest

Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.

Factors involved in megakaryocyte development and platelet production

Synonyms and Secondary IDs (12)

Reported As

Symbol Synonym

BcDNA:GH01486

BcDNA:LD11215

CG32534

(Ashwal-Fluss et al., 2014, Keleman et al., 2009.8.5)

CG32535

(Dallman, 2004.6.23, Giot et al., 2003)

CG33525

(Chen et al., 2012, Keleman et al., 2009.8.5, Haussmann et al., 2008, Ni et al., 2008, Morozova et al., 2006)

CG3878

(Bjorklund et al., 2006, Friedman and Perrimon, 2006)

CG42687

(Hosono et al., 2015, FlyBase Genome Annotators, 2010)

CoREST

(Horvath et al., 2016, Yu et al., 2015, Domanitskaya and Schüpbach, 2012, Xu and Gridley, 2012, Thompson and Travers, 2008, Tsuda et al., 2006, Dallman et al., 2004)

CoRESTG

(Das et al., 2013)

CoRest

(Bischof et al., 2018, Zhang et al., 2018, Yang and Xi, 2017, Dietz et al., 2015, Kang et al., 2015, Schertel et al., 2015, Ashwal-Fluss et al., 2014, Lee and Spradling, 2014, Curtis et al., 2013, Japanese National Institute of Genetics, 2012.5.21, Mackay et al., 2012, Meier et al., 2012, Friedman et al., 2011, Gan et al., 2010, Wasbrough et al., 2010)

dCoREST

(Meier et al., 2012, Dallman et al., 2004)

i169

(Battersby et al., 2003)

Name Synonyms

CG33525

CoRest

Secondary FlyBase IDs

FBpp0074493
FBtr0074726
FBpp0074495
FBgn0052534
FBgn0053525
FBgn0031025
FBgn0046809
FBgn0052535
FBgn0063163
FBtr0074722
FBpp0074491
FBtr0074723
FBpp0074492
FBtr0074724

Datasets (0)

Study focus (0)

Experimental Role

Project

Project Type

Title

References (66)

The following external sites may use different assemblies or annotations than FlyBase.

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