FB2020_01, released Feb 12, 2020

Gene: Dmel\CoRest

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General Information
Symbol
Dmel\CoRest
Species
D. melanogaster
Name
CoRest
Annotation Symbol
CG42687
Feature Type
protein_coding_gene
FlyBase ID
FBgn0261573
Gene Model Status
Current
Stock Availability
12 publicly available
Gene Snapshot
CoRest (CoRest) encodes a DNA binding factor that controls transcription in cooperation with other transcriptional regulators. It positively modulates Notch signaling as well as showing co-repressor activity via histone modification regulation. [Date last reviewed: 2019-02-28]
Other Summaries
Also Known As

dCoREST

Key Links
Genomic Location
Cytogenetic map
18C8-18C8
Sequence location
X:19,521,929..19,530,896 [+]
Recombination map

1-62

RefSeq locus
NC_004354 REGION:19521929..19530896
Sequence
Get Decorated FASTA
Genomic Maps
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
NCBI
UCSC
Ensembl
PopFly
Function
GO Summary Ribbons
Gene Group (FlyBase)
Protein Family (UniProt)
Belongs to the CoREST family. (Q59E36)
Protein Signatures (InterPro)
Molecular Function (GO)
[Detailed GO annotations]
Experimental Evidence
chromatin binding; protein binding; transcription corepressor activity
Predictions / Assertions
DNA-binding transcription factor activity; transcription corepressor activity; transcription factor binding; transcription regulatory region DNA binding
Summaries
Gene Group (FlyBase)
SANT-MYB DOMAIN TRANSCRIPTION REGULATORS -
The SANT-MYB domain transcription regulators are essentially part of chromatin remodelling complexes and co-repressors. The SANT domain shows similarity with DNA-binding helix-turn-helix of Myb domain, and are involved in protein-protein interactions in the chromatin complexes. (Adapted from PMID:15040448).
Protein Function (UniProtKB)
Essential component of a corepressor complex that represses transcription of neuron-specific genes in non-neuronal cells. The BHC complex is recruited by Ttk88 and probably acts by deacetylating and demethylating specific sites on histones, thereby acting as a chromatin modifier. May serve as a molecular beacon for the recruitment of molecular machinery that imposes silencing across a chromosomal interval.
(UniProt, Q59E36)
Summary (Interactive Fly)
Gene Model and Products
Number of Transcripts
10
Number of Unique Polypeptides
6

Please see the GBrowse view of Dmel\CoRest or the JBrowse view of Dmel\CoRest for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Comments on Gene Model

Gene model includes transcripts encoding non-overlapping portions of the full CDS.

Low-frequency RNA-Seq exon junction(s) not annotated.

Supported by strand-specific RNA-Seq data.

Gene model reviewed during 5.48

Sequence Ontology: Class of Gene
nuclear_gene
protein_coding_gene
Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
CoRest-RA
FBtr0302860
NM_001014756
1839
273
CoRest-RC
FBtr0302861
NM_001014754
1800
273
CoRest-RD
FBtr0302859
NM_001014755
2085
273
CoRest-RE
FBtr0302862
NM_001014753
3290
588
CoRest-RF
FBtr0302864
NM_001014752
3296
590
CoRest-RG
FBtr0302863
NM_001201742
3998
824
CoRest-RH
FBtr0307901
NM_001258824
3155
824
CoRest-RI
FBtr0307902
NM_001258825
3255
824
CoRest-RJ
FBtr0307903
NM_001258826
2203
336
CoRest-RK
FBtr0336667
NM_001272777
1834
268
Additional Transcript Data and Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
RefSeq ID
GenBank
CoRest-PA
FBpp0292000
30.5
273
6.97
NP_001014756
AAF48966
CoRest-PC
FBpp0292001
30.5
273
6.97
NP_001014754
AAN09498
CoRest-PD
FBpp0291999
30.5
273
6.97
NP_001014755
AAN09497
CoRest-PE
FBpp0292002
62.5
588
5.36
NP_001014753
AAX52508
CoRest-PF
FBpp0292004
62.7
590
5.36
NP_001014752
AAX52507
CoRest-PG
FBpp0292003
87.3
824
6.42
NP_001188671
ADV37753
CoRest-PH
FBpp0300335
87.3
824
6.42
NP_001245753
AFH07465
CoRest-PI
FBpp0300336
87.3
824
6.42
NP_001245754
AFH07466
CoRest-PJ
FBpp0300337
34.4
336
4.53
NP_001245755
AFH07467
CoRest-PK
FBpp0307648
30.0
268
6.89
NP_001259706
AGB95546
Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

273 aa isoforms: CoRest-PA, CoRest-PC, CoRest-PD
824 aa isoforms: CoRest-PG, CoRest-PH, CoRest-PI
Additional Polypeptide Data and Comments
Reported size (kDa)
Comments
External Data
Subunit Structure (UniProtKB)

Component of a complex that contains at least Rpd3, CoRest and Su(var)3-3/Hdm. Interacts with neuronal repressor ttk/Ttk88.

(UniProt, Q59E36)
Crossreferences
InterPro - A database of protein families, domains and functional sites
Linkouts
Sequences Consistent with the Gene Model
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\CoRest using the Feature Mapper tool.

External Data
Crossreferences
Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
Linkouts
Gene Ontology (13 terms)
Molecular Function (6 terms)
Terms Based on Experimental Evidence (3 terms)
CV Term
Evidence
References
chromatin binding
inferred from direct assay
(Dallman et al., 2004)
protein binding
inferred from physical interaction with FLYBASE:chn; FB:FBgn0015371
(Tsuda et al., 2006)
inferred from physical interaction with FLYBASE:ttk; FB:FBgn0003870
(Dallman et al., 2004)
transcription corepressor activity
inferred from direct assay
(Dallman et al., 2004)
Terms Based on Predictions or Assertions (4 terms)
CV Term
Evidence
References
DNA-binding transcription factor activity
inferred from biological aspect of ancestor with PANTHER:PTN001043031
(assigned by GO_Central )
(Gaudet et al., 2011)
transcription corepressor activity
inferred from biological aspect of ancestor with PANTHER:PTN000412750
(assigned by GO_Central )
(Gaudet et al., 2011)
transcription factor binding
inferred from biological aspect of ancestor with PANTHER:PTN001043031
(assigned by GO_Central )
(Gaudet et al., 2011)
transcription regulatory region DNA binding
inferred from biological aspect of ancestor with PANTHER:PTN001043031
(assigned by GO_Central )
(Gaudet et al., 2011)
Biological Process (5 terms)
Terms Based on Experimental Evidence (4 terms)
CV Term
Evidence
References
negative regulation of histone H3-K27 methylation
inferred from mutant phenotype
(Domanitskaya and Schüpbach, 2012)
negative regulation of histone H4-K16 acetylation
inferred from mutant phenotype
(Domanitskaya and Schüpbach, 2012)
negative regulation of transcription, DNA-templated
inferred from direct assay
(Dallman et al., 2004)
positive regulation of methylation-dependent chromatin silencing
inferred from mutant phenotype
(Yu et al., 2015)
Terms Based on Predictions or Assertions (1 term)
CV Term
Evidence
References
negative regulation of transcription by RNA polymerase II
inferred from sequence or structural similarity with HGNC:17441
(Dallman et al., 2004)
Cellular Component (2 terms)
Terms Based on Experimental Evidence (2 terms)
CV Term
Evidence
References
nucleus
inferred from direct assay
(Dallman et al., 2004)
transcriptional repressor complex
inferred from physical interaction with FLYBASE:inferred from high throughput direct assayC1; FB:FBgn0015805
(Dallman et al., 2004)
inferred from physical interaction with FLYBASE:Su(var)3-3; FB:FBgn0260397
(Dallman et al., 2004)
Terms Based on Predictions or Assertions (2 terms)
CV Term
Evidence
References
nucleus
inferred from biological aspect of ancestor with PANTHER:PTN001043031
(assigned by GO_Central )
(Gaudet et al., 2011)
transcriptional repressor complex
inferred from biological aspect of ancestor with PANTHER:PTN000412750
(assigned by GO_Central )
(Gaudet et al., 2011)
Expression Data
Expression Summary Ribbons
Colored tiles in ribbon indicate that expression data has been curated by FlyBase for that anatomical location. Colorless tiles indicate that there is no curated data for that location.
For complete stage-specific expression data, view the modENCODE Development RNA-Seq section under High-Throughput Expression below.
Transcript Expression
in situ
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage 1 -- 3
organism

Comment: maternally deposited

(Fisher et al., 2012)
embryonic stage 4 -- 6
organism | ubiquitous
(Fisher et al., 2012)
embryonic stage 7 -- 8
organism | ubiquitous
(Fisher et al., 2012)
embryonic stage 9 -- 10
organism | ubiquitous
(Fisher et al., 2012)
embryonic stage 11 -- 12
organism | ubiquitous
(Fisher et al., 2012)
embryonic stage 13 -- 16
organism | ubiquitous
(Fisher et al., 2012)
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Polypeptide Expression
immunolocalization
Stage
Tissue/Position (including subcellular localization)
Reference
adult stage | female & oogenesis
follicle cell
(Domanitskaya and Schüpbach, 2012)
female germline cell
(Domanitskaya and Schüpbach, 2012)
mass spectroscopy
Stage
Tissue/Position (including subcellular localization)
Reference
day 5 of adulthood & male -- day 7 of adulthood & male
spermatozoon
(Wasbrough et al., 2010)
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Evidence
References
nucleus
inferred from direct assay
(Dallman et al., 2004)
transcriptional repressor complex
inferred from physical interaction with FLYBASE:inferred from high throughput direct assayC1; FB:FBgn0015805
(Dallman et al., 2004)
inferred from physical interaction with FLYBASE:Su(var)3-3; FB:FBgn0260397
(Dallman et al., 2004)
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\CoRest in GBrowse 2
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Bulk Downloads
RNA-Seq RPKM values for all genes
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
FLIGHT - Cell culture data for RNAi and other high-throughput technologies
Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
Images
FlyBase Wiki
Image Based Resources
Alleles, Insertions, and Transgenic Constructs
Classical and Insertion Alleles ( 5 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 12 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of CoRest
Transgenic constructs containing regulatory region of CoRest
Deletions and Duplications ( 2 )
Phenotypes
Orthologs
Downloads
Download All DIOPT Orthologs
Download All OrthoDB Orthologs
Human Orthologs (via DIOPT v7.1)
Homo sapiens (Human) (4)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
eggNOG
Hieranoid
Homologene
Inparanoid
Isobase
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
RoundUp
TreeFam
ZFIN
Alignment
Complementation?
Transgene?
Hsap\RCOR2
11 of 15
Yes
Yes
Hsap\RCOR1
10 of 15
No
Yes
 
Hsap\RCOR3
10 of 15
No
Yes
Hsap\NCOR1
1 of 15
No
No
 
Model Organism Orthologs (via DIOPT v7.1)
Mus musculus (laboratory mouse) (4)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
eggNOG
Hieranoid
Homologene
Inparanoid
Isobase
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
RoundUp
TreeFam
ZFIN
Alignment
Complementation?
Transgene?
Mmus\Rcor1
12 of 15
Yes
Yes
Mmus\Rcor2
10 of 15
No
Yes
Mmus\Rcor3
10 of 15
No
Yes
Mmus\Elmsan1
1 of 15
No
No
Rattus norvegicus (Norway rat) (8)
Rnor\LOC102552640
9 of 13
Yes
Yes
Rnor\Rcor1
7 of 13
No
Yes
Rnor\Rcor3
7 of 13
No
Yes
Rnor\Rcor2
4 of 13
No
Yes
Rnor\Elmsan1
1 of 13
No
No
Rnor\Mier2
1 of 13
No
No
Rnor\Mier3
1 of 13
No
No
Rnor\Rcor2l1
1 of 13
No
Yes
Xenopus tropicalis (Western clawed frog) (3)
Xtro\rcor1
11 of 12
Yes
Yes
Xtro\rcor2
10 of 12
No
Yes
Xtro\rcor3
6 of 12
No
Yes
Danio rerio (Zebrafish) (4)
Drer\rcor1
11 of 15
Yes
Yes
Drer\rcor2
11 of 15
Yes
Yes
Drer\rcor3
10 of 15
No
Yes
Drer\elmsan1a
1 of 15
No
No
Caenorhabditis elegans (Nematode, roundworm) (2)
Cele\spr-1
11 of 15
Yes
Yes
Cele\rcor-1
10 of 15
No
Yes
Arabidopsis thaliana (thale-cress) (0)
No records found.
Saccharomyces cerevisiae (Brewer's yeast) (1)
Scer\SNT1
2 of 15
Yes
No
Schizosaccharomyces pombe (Fission yeast) (0)
No records found.
Orthologs in Drosophila Species (via OrthoDB v9.1) ( EOG091907AQ )
Organism
Common Name
Gene
AAA Syntenic Ortholog
Multiple Dmel Genes in this Orthologous Group
Drosophila melanogaster
fruit fly
Dmel\CoRest
Drosophila suzukii
Spotted wing Drosophila
Dsuz\DS10_00004768
Drosophila simulans
Dsim\GD17446
Drosophila sechellia
Dsec\GM22965
Drosophila erecta
Dere\GG19230
Drosophila yakuba
Dyak\GE15848
Drosophila ananassae
Dana\GF20196
Drosophila pseudoobscura pseudoobscura
Dpse\GA22699
Drosophila persimilis
Dper\GL14535
Drosophila willistoni
Dwil\GK25833
Drosophila virilis
Dvir\GJ15743
Drosophila mojavensis
Dmoj\GI16095
Drosophila grimshawi
Dgri\GH17657
Orthologs in non-Drosophila Dipterans (via OrthoDB v9.1) ( EOG091504HE )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Musca domestica
House fly
Mdoa\17009135
Glossina morsitans
Tsetse fly
Gmor\GMOY004766
Lucilia cuprina
Australian sheep blowfly
Lcup\FF38_01107
Lucilia cuprina
Australian sheep blowfly
Lcup\FF38_05301
Mayetiola destructor
Hessian fly
Mdes\Mdes007322
Aedes aegypti
Yellow fever mosquito
Aaeg\AAEL001126
Anopheles darlingi
American malaria mosquito
Adar\ADAC004775
Anopheles gambiae
Malaria mosquito
Agam\AGAP002488
Culex quinquefasciatus
Southern house mosquito
Cqui\CPIJ009982
Orthologs in non-Dipteran Insects (via OrthoDB v9.1) ( EOG090W04B4 )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Bombyx mori
Silkmoth
Bmor\BGIBMGA008364
Danaus plexippus
Monarch butterfly
Dple\DPOGS211367-PA
Heliconius melpomene
Postman butterfly
Hmel\HMEL002792
Apis florea
Little honeybee
Aflo\2664494068
Apis mellifera
Western honey bee
Amel\GB52614
Bombus impatiens
Common eastern bumble bee
Bimp\BIMP12022
Bombus terrestris
Buff-tailed bumblebee
Bter\15213588
Linepithema humile
Argentine ant
Lhum\LH24381
Megachile rotundata
Alfalfa leafcutting bee
Mrot\MROTU:00251f
Nasonia vitripennis
Parasitic wasp
Nvit\Nasvi2EG021063
Tribolium castaneum
Red flour beetle
Tcas\GLEAN_07336
Pediculus humanus
Human body louse
Phum\PHUM256790
Rhodnius prolixus
Kissing bug
Rpro\RPRC007001
Cimex lectularius
Bed bug
Clec\CLEC002819
Acyrthosiphon pisum
Pea aphid
Apim\ACYPI004445
Acyrthosiphon pisum
Pea aphid
Apim\ACYPI24793
Zootermopsis nevadensis
Nevada dampwood termite
Znev\Znev_02708
Orthologs in non-Insect Arthropods (via OrthoDB v9.1) ( EOG090X04QV )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strigamia maritima
European centipede
Smar\SMAR003351
Ixodes scapularis
Black-legged tick
Isca\ISCW012950
Ixodes scapularis
Black-legged tick
Isca\ISCW007037
Stegodyphus mimosarum
African social velvet spider
Smim\KFM70515.1
Tetranychus urticae
Two-spotted spider mite
Turt\tetur37g00390
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_248217
Orthologs in non-Arthropod Metazoa (via OrthoDB v9.1) ( EOG091G096Y )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strongylocentrotus purpuratus
Purple sea urchin
Spur\SPU_017381gn
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Rcor3
Ciona intestinalis
Vase tunicate
Cint\ENSCING00000023994
Gallus gallus
Domestic chicken
Ggal\RCOR1
Gallus gallus
Domestic chicken
Ggal\ENSGALG00000009871
Paralogs
Downloads
Download All DIOPT Paralogs
Paralogs (via DIOPT v7.1)
Drosophila melanogaster (Fruit fly) (3)
Gene Symbol
Score
Source
Compara
eggNOG
Homologene
Inparanoid
Isobase
OrthoDB
OrthoFinder
orthoMCL
Panther
RoundUp
Alignment
CG31875
3 of 10
CG16779
1 of 10
Smr
1 of 10
Human Disease Associations
FlyBase Human Disease Model Reports
    Disease Model Summary Ribbon
    Disease Ontology (DO) Annotations
    Models Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Evidence
    References
    Potential Models Based on Orthology ( 0 )
    Human Ortholog
    Disease
    Evidence
    References
    Modifiers Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Interaction
    References
    Disease Associations of Human Orthologs (via DIOPT v7.1 and OMIM)
    Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
    Homo sapiens (Human)
    Gene name
    Score
    OMIM
    OMIM Phenotype
    DO term
    Complementation?
    Transgene?
    RCOR2; REST corepressor 2
    11 of 15
    616019
        RCOR1; REST corepressor 1
        10 of 15
        607675
             
            RCOR3; REST corepressor 3
            10 of 15
                Functional Complementation Data
                Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
                Interactions
                Summary of Physical Interactions
                Summary of Genetic Interactions
                esyN Network Diagram
                esyN Network Key:
                Suppression
                Enhancement
                View in Interactions Browser
                Please look at the allele data for full details of the genetic interactions
                Starting gene(s)
                Interaction type
                Interacting gene(s)
                Reference
                Starting gene(s)
                Interaction type
                Interacting gene(s)
                Reference
                Dl
                enhanceable
                CoRest
                (Domanitskaya and Schüpbach, 2012)
                Ras85D
                suppressible
                CoRest
                (Friedman et al., 2011)
                External Data
                Subunit Structure (UniProtKB)
                Component of a complex that contains at least Rpd3, CoRest and Su(var)3-3/Hdm. Interacts with neuronal repressor ttk/Ttk88.
                (UniProt, Q59E36 )
                Linkouts
                DroID - A comprehensive database of gene and protein interactions.
                InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.
                MIST (protein-protein) - An integrated Molecular Interaction Database
                Pathways
                Signaling Pathways (FlyBase)
                Metabolic Pathways
                External Data
                Linkouts
                Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
                Genomic Location and Detailed Mapping Data
                Chromosome (arm)
                X
                Recombination map

                1-62

                Cytogenetic map
                18C8-18C8
                Sequence location
                X:19,521,929..19,530,896 [+]
                FlyBase Computed Cytological Location
                Cytogenetic map
                Evidence for location
                18C8-18C8
                Limits computationally determined from genome sequence between P{EP}EP1526&P{EP}PfrxEP1150 and P{EP}Tao-1EP1455
                Experimentally Determined Cytological Location
                Cytogenetic map
                Notes
                References
                Experimentally Determined Recombination Data
                Location

                1-62

                (FlyBase, 2016)

                1-62.1

                (Comeron et al., 2012)
                Left of (cM)
                Right of (cM)
                (Domanitskaya and Schüpbach, 2012)
                Notes
                Stocks and Reagents
                Stocks (12)
                Genomic Clones (21)
                cDNA Clones (132)
                 

                Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

                cDNA clones, fully sequences
                BDGP DGC clones
                Other clones
                Drosophila Genomics Resource Center cDNA clones

                For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

                cDNA Clones, End Sequenced (ESTs)
                BDGP DGC clones
                Other clones
                RNAi and Array Information
                Linkouts
                DRSC - Results frm RNAi screens
                GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
                Antibody Information
                Laboratory Generated Antibodies
                 
                Commercially Available Antibodies
                 
                Other Information
                Relationship to Other Genes
                Source for database identify of

                Source for identity of: CoRest CG33525

                (Dallman et al., 2004)
                Source for database merge of

                Source for merge of: CG3878 CG32535

                (Dallman, 2004.6.23)

                Source for merge of: CoRest CG32534

                (FlyBase Genome Annotators, 2010)

                Source for merge of: CG32535 BcDNA:GH01486

                (FlyBase, 1996-)

                Source for merge of: CG3878 BcDNA:LD11215

                (FlyBase, 1996-)
                Additional comments

                Annotations CG33525 and CG32534 merged as CG42687 in release 5.25 of the genome annotation.

                (FlyBase Genome Annotators, 2010)

                Annotations CG3878 and CG32535 merged as CG33525 in release 4.1 of the genome annotation.

                (FlyBase Genome Annotators, 2005)

                Source for merge of CG32535 BcDNA:GH01486 was a shared cDNA ( date:030728 ).

                (FlyBase, 1996-)

                Source for merge of CG3878 BcDNA:LD11215 was a shared cDNA ( date:020730 ).

                (FlyBase, 1996-)
                Other Comments

                CoRest positively regulates N signaling, acting downstream of the proteolytic cleavage of the N protein, but upstream of peb activity.

                (Domanitskaya and Schüpbach, 2012)

                New annotation (CG32535) in release 3 of the genome annotation.

                (FlyBase Genome Annotators, 2002-2003)

                New annotation (CG32534) in release 3 of the genome annotation.

                (FlyBase Genome Annotators, 2002-2003)
                Origin and Etymology
                Discoverer
                Etymology
                Identification

                As a putative ortholog for mammalian "CoREST" due to DNA sequence similarity.

                (Dallman et al., 2004)
                External Crossreferences and Linkouts ( 72 )
                Sequence Crossreferences
                NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
                GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
                GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
                RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
                UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information
                UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information
                Other crossreferences
                BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
                Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones
                Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
                Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
                FlyMine - An integrated database for Drosophila genomics
                GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
                iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)
                InterPro - A database of protein families, domains and functional sites
                KEGG Genes - Molecular building blocks of life in the genomic space.
                modMine - A data warehouse for the modENCODE project
                Linkouts
                DroID - A comprehensive database of gene and protein interactions.
                DRSC - Results frm RNAi screens
                FLIGHT - Cell culture data for RNAi and other high-throughput technologies
                Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution
                InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.
                MIST (protein-protein) - An integrated Molecular Interaction Database
                Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
                Synonyms and Secondary IDs (12)
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                References (65)