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Gene Dmel\RpS6

General Information
Symbol	Dmel\RpS6	Species	D. melanogaster
Name	Ribosomal protein S6	Annotation symbol	CG10944
Feature type	protein_coding_gene	FlyBase ID	FBgn0261592
Gene Model Status	Current	Stock availability	2 publicly available
Also Known As	S6, air8, l(1)air8, hen
Genomic Location
Chromosome (arm)	X	Recombination map	1-[21]
Cytogenetic map	7C1-7C2	Sequence location	X:7,793,653..7,795,362 [-]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents modENCODE GBrowse	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene Ribosomal protein S6 is referred to in FlyBase by the symbol Dmel\RpS6 (CG10944, FBgn0261592). It is a protein_coding_gene from Drosophila melanogaster. Based on sequence similarity, it is predicted to have molecular function: structural constituent of ribosome. There is experimental evidence that it is involved in the biological process: mitotic spindle elongation; mitotic spindle organization; centrosome duplication. 8 alleles are reported. The phenotype of these alleles is annotated with: embryonic/larval lymph gland. It has 2 annotated transcripts and 2 annotated polypeptides. Protein features are: Ribosomal protein S6, eukaryotic; Ribosomal protein S6e; Ribosomal protein S6e, conserved site. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of extremely high expression to a trough of very high expression. Peak expression observed at stages throughout embryogenesis, at stages throughout the larval period, during early pupal stages, in adult female stages. Summary of FlyAtlas Anatomical Expression Data: High levels of expression observed in all larval and adult organs/tissues. Expression at high levels in the following post-embryonic organs or tissues: adult head, adult eye, larval/adult central nervous system, adult crop, larval/adult midgut, larval/adult hindgut, larval/adult Malpighian tubules, adult heart, larval/adult fat body, larval/adult salivary gland, larval trachea, adult female reproductive system, adult male reproductive system, larval/adult carcass. Comments on Affy2 ProbeSet: ProbeSet 1626924_a_at completely aligns to an exonic region common to each of the 2 FlyBase-annotated transcript isoforms of RpS6. Gene sequence location is X:7793653..7795362.
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2011_10	References Alonso and Santaren, 2006, J. Proteome Res. 5(8): 2025--2032
FB2012_01	Controlled Vocabulary Terms centrosome duplication Sequence features BKN27652 HFA18712 BKN46529 References Müller et al., 2010, EMBO J. 29(19): 3344--3357
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 7C1-7C2   Left limit from inclusion within Df(1)hl-c (FBrf0052091) Right limit from inclusion within Df(1)hl-a (FBrf0052091); Limits computationally determined from genome sequence between P{EP}EP1209 and P{EP}CG10777EP1347&P{EP}CG10777EP1363
Experimentally Determined Cytological Location
Cytogenetic map Notes References 7C5-7C9     (Stewart, 1994.3.23) 7B-7C     (Spencer, 1992) 7C-7C   (determined by in situ hybridisation) 7C5--D1 (determined by in situ hybridisation)   (Stewart and Denell, 1993) 7C-7C   (determined by in situ hybridisation)   (Spencer and Mackie, 1993) 7C3-7D2   (determined by in situ hybridisation)   (Watson et al., 1992)
Experimentally Determined Recombination Data
Location	1-20.45 (Stewart and Denell, 1993, Stewart, 1994.3.23) 1-[21]
Left of (cM)	v (Stewart and Denell, 1993)
Right of (cM)	ct (Stewart and Denell, 1993)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\RpS6 for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
	EST data suggest additional 5' exon(s)
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) RpS6-RA FBtr0071136  NM_167136   1130   217 RpS6-RB FBtr0071135  NM_078518   962   248
Additional Transcript Data & Comments
Reported size (kB)	1.1 (northern blot) (Watson et al., 1992)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein RpS6-PA   FBpp0071088   24.7   217   11.70     NP_727213   AAF46288 RpS6-PB   FBpp0071087   28.4   248   11.43     NP_511073   AAN09218
Additional Polypeptide Data & Comments
Reported size (kDa)	248 (aa) (Watson et al., 1992)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Ribosomal protein S6e, conserved site (IPR018282) Ribosomal protein S6e (IPR001377) Ribosomal protein S6, eukaryotic (IPR014401)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA202280   AA246839   AA247025   AA391608   AA392757   AA439428   AA540023   AA541044   AA541107   AA567764   AA694873   AA695404   AA695488   AA695869   AA696567   AA697352   AA698617   AA735269   AA735349   AA735615   AA735913   AA801551   AA802506   AA802715   AA802766   AA803703   AA816437   AA817253   AA820201   AA820878   AA940921   AA940973   AA941880   AA942450   AA951028   AA951242   AA951385   AA951753   AA951821   AA951849   AA990769   AE014298 AAF46288   AE014298 AAN09218   AI063437   AI107214   AI107487   AI108102   AI113368   AI134160   AI135661   AI135772   AI238893   AI239035   AI257347   AI257560   AI260008   AI260904   AI260916   AI292497   AI293179   AI294412   AI295094   AI296423   AI296488   AI296781   AI297837   AI387131   AI388024   AI388087   AI388615   AI389783   AI403532   AI404532   AI405067   AI405264   AI405704   AI406113   AI455803   AI456353   AI456427   AI456508   AI511876   AI514835   AI515430   AI515495   AI515899   AI515913   AI516647   AI516702   AI517713   AI517801   AI518741   AI518850   AI519830   AI519887   AI520554   AI534717   AI544219   AW943078   AX664487   AY058620 AAL13849   AY231781   AY232048   BE977151   BF488042   BF489238   BF490638   BF503489   BG633061   BG633377   BG635447   BG635610   BG635942   BG635985   BG636225   BG637202   BG637285   BG637404   BG640167   BG640449   BG640669   BI141977   BI164236   BI165364   BI166256   BI168937   BI173086   BI214526   BI228273   BI230110   BI230187   BI232589   BI234026   BI237129   BI237898   BI239381   BI243012   BI354260   BI354301   BI354343   BI354345   BI354359   BI354368   BI354390   BI354403   BI358649   BI358690   BI358693   BI358715   BI358716   BI358718   BI362258   BI362540   BI364367   BI365953   BI367878   BI565457   BI566291   BI566331   BI566929   BI566944   BI566974   BI575323   BI576530   BI576791   BI582289   BI585729   BI587372   BI587913   BI588012   BI588066   BI604258   BI604917   BI607676   BI608200   BI608849   BI609123   BI611773   BI612418   BI616328   BI616510   BI617422   BI628923   BI631788   BI633141   BI633895   BI634239   BI635645   BI636672   BI637108   BI637787   BI637868   BI638310   BI639845   BI640027   BI640614   BI640765   BI641070   BI641359   BP541845   BP545561   BP545562   BP547750   BP548525   BP548732   BP548780   BP548781   BP548869   BP549107   BP549108   BP550563   BP550564   BP550981   BP550982   BP551418   BP551419   BP551871   BP551872   BP552117   BP552118   BP553822   BP553823   BP554692   BP554693   BP554737   BP554853   BP554854   BP555484   BP555485   BP555883   BP555884   BP556244   BP556245   BP556989   BP556990   BP557435   BP557436   BP559428   BP559429   BQ102778   BQ103018   BQ103020   BQ103024   BQ103390   BT023909   BT030942   BT120122   BX015062   BX017102   BX019556   BX047758   BX059515   CA803887   CA804457   CA804668   CA805601   CK132071   CK132444   CK604569   CK604570   CK605411   CK605412   CK657869   CK658319   CK660021   CK660833   CO153179   CO153185   CO154027   CO154882   CO156533   CO157067   CO180541   CO182723   CO183401   CO185273   CO191166   CO269957   CO275418   CO277115   CO296679   CO300040   CO306708   CO325054   CO333545   CO335363   CO335630   CO335714   CO335767   CO336049   CO336131   CO336252   CO336314   CO337745   CO337877   CO338702   CO338875   CO338877   CR938364   EC051350   EC052772   EC053119   EC067967   EC068392   EC081648   EC086362   EC211104   EC213110   EC214653   EC225395   EC229489   EC232717   EC248947   EC261286   EC261958   EC262123   EC262161   EC262259   EC262607   EC262668   EC262669   EC263173   EC263211   EC264103   EC264156   EC264183   EC264604   EC266262   EC266270   EC266847   EC267035   EC267093   EC268047   EL874659   EL880116   EL880198   EL880199   EL883520   EL883521   EL883546   ES688792   ES693576   ES694705   ES694717   ES694743   ES694756   ES695213   EV575006   EV575215   EV575536   EV576172   EV576211   EV576283   EV576505   EV576837   EV577021   EV577059   EV577242   EV577474   EV578155   EV578219   EV578336   EV578375   EV578799   EV579076   EV579138   EV579403   EV579443   EV580117   EV580322   EV580501   EV580511   EV580723   EV580728   EV581026   EV581099   EV581122   EV581565   EV581836   EV581846   EV581960   EV582235   EV582397   EV582515   EV582572   EV582739   EV582759   EV583210   EV583345   EV583356   EV583507   EV583935   EV584188   EV584450   EV584612   EV584840   EV585004   EV585010   EV585494   EV585773   EV586012   EV586195   EV586324   EV587400   EV588669   EV589924   EV589947   EV591006   EV591475   EV593232   EV593526   EV593896   EV594079   EV594697   EV595173   EV595394   EV595747   EV596801   EV597915   EV598159   EV598609   EV599534   EV599767   EV599782   GH778663   GH857392   GH884352   GH923095   L01658 AAC34306   L02074 AAB05982   L02074 AAB05983   L02074 AAB05984   L02075 AAB05985   L07881 AAA28871
UniProtKB/Swiss-Prot	P29327
UniProtKB/TrEMBL	Q95TP9
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
No Assay Recorded Stage Tissue/Position (including subcellular localization) Reference embryonic stage -- adult stage     (Watson et al., 1992) expression microarray Stage Tissue/Position (including subcellular localization) Reference adult stage | female     (Arbeitman et al., 2004)
Additional Descriptive Data
	Mutant RpS6 transcripts are barely detectable on northern blots of @RpS6air8 RNA. (Watson et al., 1992) RpS6 transcripts are abundant throughout development. (Watson et al., 1992)
Marker for
Subcellular Localization
CV Term
Notes
Polypeptide Expression
mass spectroscopy Stage Tissue/Position (including subcellular localization) Reference day 7 of adulthood -- day 49 of adulthood   adult heart   (Cammarato et al., 2011)
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
High-Throughput Expression Data
or
See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes. modENCODE Temporal Expression Data for FBgn0261592    Styles Linear Logarithmic Heatmap    Scales max expr for FBgn0261592 Very low expression bin max Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of extremely high expression to a trough of very high expression. Peak expression observed at stages throughout embryogenesis, at stages throughout the larval period, during early pupal stages, in adult female stages. [download data (TSV)] Guide to modENCODE expression level colors   No expression (0 - 0)   Extremely low expression (1 - 10)   Very low expression (11 - 100)   Low expression (101 - 400)   Moderate expression (401 - 1400)   Moderately high expression (1401 - 4000)   High expression (4001 - 10000)   Very high expression (10001 - 100000)   Extremely high expression (100001 - 2000000) Linear, scaled to maximum FBgn0261592 expression level Developmental Stage   Expression Level embryo 00-02hr    121878 embryo 02-04hr    202696 embryo 04-06hr    198793 embryo 06-08hr    221996 embryo 08-10hr    224998 embryo 10-12hr    274435 embryo 12-14hr    172028 embryo 14-16hr    222219 embryo 16-18hr    190024 embryo 18-20hr    201140 embryo 20-22hr    230914 embryo 22-24hr    171989 larva L1    217763 larva L2    179933 larva L3 12hr old    146209 larva L3 puffstage 1-2    119479 larva L3 puffstage 3-6    118190 larva L3 puffstage 7-9    112205 white prepupae new    110689 white prepupae 12hr    101116 white prepupae 24hr    98925 pupae 2d postWPP    85456 pupae 3d postWPP    70070 pupae 4d postWPP    85196 adult male 01day    61895 adult male 05day    59711 adult male 30day    69052 adult female 01day    157657 adult female 05day    136654 adult female 30day    137039 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Linear, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (121878) embryo 02-04hr  (202696) embryo 04-06hr  (198793) embryo 06-08hr  (221996) embryo 08-10hr  (224998) embryo 10-12hr  (274435) embryo 12-14hr  (172028) embryo 14-16hr  (222219) embryo 16-18hr  (190024) embryo 18-20hr  (201140) embryo 20-22hr  (230914) embryo 22-24hr  (171989) larva L1  (217763) larva L2  (179933) larva L3 12hr old  (146209) larva L3 puffstage 1-2  (119479) larva L3 puffstage 3-6  (118190) larva L3 puffstage 7-9  (112205) white prepupae new  (110689) white prepupae 12hr  (101116) white prepupae 24hr  (98925) pupae 2d postWPP  (85456) pupae 3d postWPP  (70070) pupae 4d postWPP  (85196) adult male 01day  (61895) adult male 05day  (59711) adult male 30day  (69052) adult female 01day  (157657) adult female 05day  (136654) adult female 30day  (137039) Expression Level Scale  None   Extremely low   Very low   Low  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (121878) embryo 02-04hr  (202696) embryo 04-06hr  (198793) embryo 06-08hr  (221996) embryo 08-10hr  (224998) embryo 10-12hr  (274435) embryo 12-14hr  (172028) embryo 14-16hr  (222219) embryo 16-18hr  (190024) embryo 18-20hr  (201140) embryo 20-22hr  (230914) embryo 22-24hr  (171989) larva L1  (217763) larva L2  (179933) larva L3 12hr old  (146209) larva L3 puffstage 1-2  (119479) larva L3 puffstage 3-6  (118190) larva L3 puffstage 7-9  (112205) white prepupae new  (110689) white prepupae 12hr  (101116) white prepupae 24hr  (98925) pupae 2d postWPP  (85456) pupae 3d postWPP  (70070) pupae 4d postWPP  (85196) adult male 01day  (61895) adult male 05day  (59711) adult male 30day  (69052) adult female 01day  (157657) adult female 05day  (136654) adult female 30day  (137039) Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr  (121878) embryo 02-04hr  (202696) embryo 04-06hr  (198793) embryo 06-08hr  (221996) embryo 08-10hr  (224998) embryo 10-12hr  (274435) embryo 12-14hr  (172028) embryo 14-16hr  (222219) embryo 16-18hr  (190024) embryo 18-20hr  (201140) embryo 20-22hr  (230914) embryo 22-24hr  (171989) larva L1  (217763) larva L2  (179933) larva L3 12hr old  (146209) larva L3 puffstage 1-2  (119479) larva L3 puffstage 3-6  (118190) larva L3 puffstage 7-9  (112205) white prepupae new  (110689) white prepupae 12hr  (101116) white prepupae 24hr  (98925) pupae 2d postWPP  (85456) pupae 3d postWPP  (70070) pupae 4d postWPP  (85196) adult male 01day  (61895) adult male 05day  (59711) adult male 30day  (69052) adult female 01day  (157657) adult female 05day  (136654) adult female 30day  (137039) Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    121878 embryo 02-04hr    202696 embryo 04-06hr    198793 embryo 06-08hr    221996 embryo 08-10hr    224998 embryo 10-12hr    274435 embryo 12-14hr    172028 embryo 14-16hr    222219 embryo 16-18hr    190024 embryo 18-20hr    201140 embryo 20-22hr    230914 embryo 22-24hr    171989 larva L1    217763 larva L2    179933 larva L3 12hr old    146209 larva L3 puffstage 1-2    119479 larva L3 puffstage 3-6    118190 larva L3 puffstage 7-9    112205 white prepupae new    110689 white prepupae 12hr    101116 white prepupae 24hr    98925 pupae 2d postWPP    85456 pupae 3d postWPP    70070 pupae 4d postWPP    85196 adult male 01day    61895 adult male 05day    59711 adult male 30day    69052 adult female 01day    157657 adult female 05day    136654 adult female 30day    137039 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  log, scaled to maximum FBgn0261592 expression level Developmental Stage   Expression Level embryo 00-02hr    121878 embryo 02-04hr    202696 embryo 04-06hr    198793 embryo 06-08hr    221996 embryo 08-10hr    224998 embryo 10-12hr    274435 embryo 12-14hr    172028 embryo 14-16hr    222219 embryo 16-18hr    190024 embryo 18-20hr    201140 embryo 20-22hr    230914 embryo 22-24hr    171989 larva L1    217763 larva L2    179933 larva L3 12hr old    146209 larva L3 puffstage 1-2    119479 larva L3 puffstage 3-6    118190 larva L3 puffstage 7-9    112205 white prepupae new    110689 white prepupae 12hr    101116 white prepupae 24hr    98925 pupae 2d postWPP    85456 pupae 3d postWPP    70070 pupae 4d postWPP    85196 adult male 01day    61895 adult male 05day    59711 adult male 30day    69052 adult female 01day    157657 adult female 05day    136654 adult female 30day    137039 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  log, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (121878) embryo 02-04hr  (202696) embryo 04-06hr  (198793) embryo 06-08hr  (221996) embryo 08-10hr  (224998) embryo 10-12hr  (274435) embryo 12-14hr  (172028) embryo 14-16hr  (222219) embryo 16-18hr  (190024) embryo 18-20hr  (201140) embryo 20-22hr  (230914) embryo 22-24hr  (171989) larva L1  (217763) larva L2  (179933) larva L3 12hr old  (146209) larva L3 puffstage 1-2  (119479) larva L3 puffstage 3-6  (118190) larva L3 puffstage 7-9  (112205) white prepupae new  (110689) white prepupae 12hr  (101116) white prepupae 24hr  (98925) pupae 2d postWPP  (85456) pupae 3d postWPP  (70070) pupae 4d postWPP  (85196) adult male 01day  (61895) adult male 05day  (59711) adult male 30day  (69052) adult female 01day  (157657) adult female 05day  (136654) adult female 30day  (137039) Expression Level Scale  None   Extremely low   Very low   Low  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (121878) embryo 02-04hr  (202696) embryo 04-06hr  (198793) embryo 06-08hr  (221996) embryo 08-10hr  (224998) embryo 10-12hr  (274435) embryo 12-14hr  (172028) embryo 14-16hr  (222219) embryo 16-18hr  (190024) embryo 18-20hr  (201140) embryo 20-22hr  (230914) embryo 22-24hr  (171989) larva L1  (217763) larva L2  (179933) larva L3 12hr old  (146209) larva L3 puffstage 1-2  (119479) larva L3 puffstage 3-6  (118190) larva L3 puffstage 7-9  (112205) white prepupae new  (110689) white prepupae 12hr  (101116) white prepupae 24hr  (98925) pupae 2d postWPP  (85456) pupae 3d postWPP  (70070) pupae 4d postWPP  (85196) adult male 01day  (61895) adult male 05day  (59711) adult male 30day  (69052) adult female 01day  (157657) adult female 05day  (136654) adult female 30day  (137039) Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr  (121878) embryo 02-04hr  (202696) embryo 04-06hr  (198793) embryo 06-08hr  (221996) embryo 08-10hr  (224998) embryo 10-12hr  (274435) embryo 12-14hr  (172028) embryo 14-16hr  (222219) embryo 16-18hr  (190024) embryo 18-20hr  (201140) embryo 20-22hr  (230914) embryo 22-24hr  (171989) larva L1  (217763) larva L2  (179933) larva L3 12hr old  (146209) larva L3 puffstage 1-2  (119479) larva L3 puffstage 3-6  (118190) larva L3 puffstage 7-9  (112205) white prepupae new  (110689) white prepupae 12hr  (101116) white prepupae 24hr  (98925) pupae 2d postWPP  (85456) pupae 3d postWPP  (70070) pupae 4d postWPP  (85196) adult male 01day  (61895) adult male 05day  (59711) adult male 30day  (69052) adult female 01day  (157657) adult female 05day  (136654) adult female 30day  (137039) Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    121878 embryo 02-04hr    202696 embryo 04-06hr    198793 embryo 06-08hr    221996 embryo 08-10hr    224998 embryo 10-12hr    274435 embryo 12-14hr    172028 embryo 14-16hr    222219 embryo 16-18hr    190024 embryo 18-20hr    201140 embryo 20-22hr    230914 embryo 22-24hr    171989 larva L1    217763 larva L2    179933 larva L3 12hr old    146209 larva L3 puffstage 1-2    119479 larva L3 puffstage 3-6    118190 larva L3 puffstage 7-9    112205 white prepupae new    110689 white prepupae 12hr    101116 white prepupae 24hr    98925 pupae 2d postWPP    85456 pupae 3d postWPP    70070 pupae 4d postWPP    85196 adult male 01day    61895 adult male 05day    59711 adult male 30day    69052 adult female 01day    157657 adult female 05day    136654 adult female 30day    137039 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     FlyAtlas Anatomical Expression Data for FBgn0261592    Styles Linear Logarithmic Heatmap Back-to-back    Scales max expr for FBgn0261592 Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: High levels of expression observed in all larval and adult organs/tissues. Expression at high levels in the following post-embryonic organs or tissues: adult head, adult eye, larval/adult central nervous system, adult crop, larval/adult midgut, larval/adult hindgut, larval/adult Malpighian tubules, adult heart, larval/adult fat body, larval/adult salivary gland, larval trachea, adult female reproductive system, adult male reproductive system, larval/adult carcass. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (1000 - 25000) Linear, scaled to maximum FBgn0261592 expression level Tissue   Expression Level Larval Central Nervous System    2330.15 Larval Midgut    3114.7 Larval Hindgut    3479.3 Larval Malpighian Tubules    3663.3 Larval Fat Body    5566.6 Larval Salivary Gland    5240.9 Larval Trachea    5615.75 Larval Carcass    3874.425 Adult Head    3630.9 Adult Eye    5823.95 Adult Brain    2687.7 Adult Thoracic-Abdominal Ganglion    3768.5 Adult Crop    4897 Adult Midgut    4095.8 Adult Hindgut    4012.8 Adult Malpighian Tubules    4058.3 Adult Fat Body    4467.1 Adult Salivary Gland    7510.6 Adult Heart    5860.2 Adult VirginFemale Spermatheca    4271.1 Adult InseminatedFemale Spermatheca    4240.7 Adult Ovary    2557 Adult Testis    632.5 Adult Male Accessory Gland    6574 Adult Carcass    4517.2 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System  (2330.15) Larval Midgut  (3114.7) Larval Hindgut  (3479.3) Larval Malpighian Tubules  (3663.3) Larval Fat Body  (5566.6) Larval Salivary Gland  (5240.9) Larval Trachea  (5615.75) Larval Carcass  (3874.425) Adult Head  (3630.9) Adult Eye  (5823.95) Adult Brain  (2687.7) Adult Thoracic-Abdominal Ganglion  (3768.5) Adult Crop  (4897) Adult Midgut  (4095.8) Adult Hindgut  (4012.8) Adult Malpighian Tubules  (4058.3) Adult Fat Body  (4467.1) Adult Salivary Gland  (7510.6) Adult Heart  (5860.2) Adult VirginFemale Spermatheca  (4271.1) Adult InseminatedFemale Spermatheca  (4240.7) Adult Ovary  (2557) Adult Testis  (632.5) Adult Male Accessory Gland  (6574) Adult Carcass  (4517.2) Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System  (2330.15) Larval Midgut  (3114.7) Larval Hindgut  (3479.3) Larval Malpighian Tubules  (3663.3) Larval Fat Body  (5566.6) Larval Salivary Gland  (5240.9) Larval Trachea  (5615.75) Larval Carcass  (3874.425) Adult Head  (3630.9) Adult Eye  (5823.95) Adult Brain  (2687.7) Adult Thoracic-Abdominal Ganglion  (3768.5) Adult Crop  (4897) Adult Midgut  (4095.8) Adult Hindgut  (4012.8) Adult Malpighian Tubules  (4058.3) Adult Fat Body  (4467.1) Adult Salivary Gland  (7510.6) Adult Heart  (5860.2) Adult VirginFemale Spermatheca  (4271.1) Adult InseminatedFemale Spermatheca  (4240.7) Adult Ovary  (2557) Adult Testis    632.5 Adult Male Accessory Gland  (6574) Adult Carcass  (4517.2) Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    2330.15 Larval Midgut    3114.7 Larval Hindgut    3479.3 Larval Malpighian Tubules    3663.3 Larval Fat Body    5566.6 Larval Salivary Gland    5240.9 Larval Trachea    5615.75 Larval Carcass    3874.425 Adult Head    3630.9 Adult Eye    5823.95 Adult Brain    2687.7 Adult Thoracic-Abdominal Ganglion    3768.5 Adult Crop    4897 Adult Midgut    4095.8 Adult Hindgut    4012.8 Adult Malpighian Tubules    4058.3 Adult Fat Body    4467.1 Adult Salivary Gland    7510.6 Adult Heart    5860.2 Adult VirginFemale Spermatheca    4271.1 Adult InseminatedFemale Spermatheca    4240.7 Adult Ovary    2557 Adult Testis    632.5 Adult Male Accessory Gland    6574 Adult Carcass    4517.2 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to maximum FBgn0261592 expression level Tissue   Expression Level Larval Central Nervous System    2330.15 Larval Midgut    3114.7 Larval Hindgut    3479.3 Larval Malpighian Tubules    3663.3 Larval Fat Body    5566.6 Larval Salivary Gland    5240.9 Larval Trachea    5615.75 Larval Carcass    3874.425 Adult Head    3630.9 Adult Eye    5823.95 Adult Brain    2687.7 Adult Thoracic-Abdominal Ganglion    3768.5 Adult Crop    4897 Adult Midgut    4095.8 Adult Hindgut    4012.8 Adult Malpighian Tubules    4058.3 Adult Fat Body    4467.1 Adult Salivary Gland    7510.6 Adult Heart    5860.2 Adult VirginFemale Spermatheca    4271.1 Adult InseminatedFemale Spermatheca    4240.7 Adult Ovary    2557 Adult Testis    632.5 Adult Male Accessory Gland    6574 Adult Carcass    4517.2 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System  (2330.15) Larval Midgut  (3114.7) Larval Hindgut  (3479.3) Larval Malpighian Tubules  (3663.3) Larval Fat Body  (5566.6) Larval Salivary Gland  (5240.9) Larval Trachea  (5615.75) Larval Carcass  (3874.425) Adult Head  (3630.9) Adult Eye  (5823.95) Adult Brain  (2687.7) Adult Thoracic-Abdominal Ganglion  (3768.5) Adult Crop  (4897) Adult Midgut  (4095.8) Adult Hindgut  (4012.8) Adult Malpighian Tubules  (4058.3) Adult Fat Body  (4467.1) Adult Salivary Gland  (7510.6) Adult Heart  (5860.2) Adult VirginFemale Spermatheca  (4271.1) Adult InseminatedFemale Spermatheca  (4240.7) Adult Ovary  (2557) Adult Testis  632.5 Adult Male Accessory Gland  (6574) Adult Carcass  (4517.2) Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System  (2330.15) Larval Midgut  (3114.7) Larval Hindgut  (3479.3) Larval Malpighian Tubules  (3663.3) Larval Fat Body  (5566.6) Larval Salivary Gland  (5240.9) Larval Trachea  (5615.75) Larval Carcass  (3874.425) Adult Head  (3630.9) Adult Eye  (5823.95) Adult Brain  (2687.7) Adult Thoracic-Abdominal Ganglion  (3768.5) Adult Crop  (4897) Adult Midgut  (4095.8) Adult Hindgut  (4012.8) Adult Malpighian Tubules  (4058.3) Adult Fat Body  (4467.1) Adult Salivary Gland  (7510.6) Adult Heart  (5860.2) Adult VirginFemale Spermatheca  (4271.1) Adult InseminatedFemale Spermatheca  (4240.7) Adult Ovary  (2557) Adult Testis    632.5 Adult Male Accessory Gland  (6574) Adult Carcass  (4517.2) Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    2330.15 Larval Midgut    3114.7 Larval Hindgut    3479.3 Larval Malpighian Tubules    3663.3 Larval Fat Body    5566.6 Larval Salivary Gland    5240.9 Larval Trachea    5615.75 Larval Carcass    3874.425 Adult Head    3630.9 Adult Eye    5823.95 Adult Brain    2687.7 Adult Thoracic-Abdominal Ganglion    3768.5 Adult Crop    4897 Adult Midgut    4095.8 Adult Hindgut    4012.8 Adult Malpighian Tubules    4058.3 Adult Fat Body    4467.1 Adult Salivary Gland    7510.6 Adult Heart    5860.2 Adult VirginFemale Spermatheca    4271.1 Adult InseminatedFemale Spermatheca    4240.7 Adult Ovary    2557 Adult Testis    632.5 Adult Male Accessory Gland    6574 Adult Carcass    4517.2 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    3630.9   NA  Eye    5823.95   NA  Brain    2687.7   2330.15  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    3768.5   NA  Crop    4897   3114.7  Midgut    4095.8   3479.3  Hindgut    4012.8   3663.3  Malpighian Tubules    4058.3   5566.6  Fat Body    4467.1   5240.9  Salivary Gland    7510.6   NA  Heart    5860.2   5615.75  Trachea    NA   NA  VirginFemale Spermatheca    4271.1   NA  InseminatedFemale Spermatheca    4240.7   NA  Ovary    2557   NA  Testis    632.5   NA  Male Accessory Gland    6574   3874.425  Carcass    4517.2 modENCODE Temporal Expression Data (Graveley et al., 2011) FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
Expression Clusters
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0004922
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele lethal RpS6air8 lethal | larval stage | recessive RpS6air8 RpS6WG1288 lethal | recessive RpS6hen1 RpS6WG1288 Other Phenotypes Allele hyperplasia | recessive RpS6air8 Phenotype manifest in Allele embryonic/larval lymph gland RpS6air8 RpS6hen1 RpS6WG1288
Classical Alleles ( 4 )
For All Classical Alleles Show
Allele of RpS6 Class Mutagen Stocks Known lesion RpS62rev Js 0 Yes RpS6air8 loss of function allele P-element activity PM hybrid dysgenesis 0 Yes RpS6hen1 P-element activity 0 Yes RpS6WG1288 loss of function allele Delta2-3 P-element activity 0 Yes
Alleles Carried on Transgenic Constructs ( 4 )
For All Alleles Carried on Transgenic Constructs Show
Allele of RpS6 Class Mutagen Stocks Known lesion RpS6HMS00413 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes RpS6KK107652 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes RpS6GD16544 in vitro construct - RNAi in vitro construct - regulatory fusion 0 Yes RpS6GD7137 in vitro construct - RNAi in vitro construct - regulatory fusion 0 Yes
Aneuploid Aberrations
Disrupted in	Df(1)hl-a (Andersson and Lambertsson, 1990) Df(1)hl-b (Andersson and Lambertsson, 1990) Df(1)hl-c (Andersson and Lambertsson, 1990) Df(1)hl-d (Andersson and Lambertsson, 1990) Df(1)sn+72d (Dorer et al., 1991)
Not duplicated in	Dp(1;Y)ct+y+ (Watson et al., 1991)
Duplicated in	Dp(1;2)sn+72d (Stewart and Denell, 1993, Watson et al., 1991) Dp(1;3)sn13a1 (Watson et al., 1991)
Not disrupted in	Dp(1;2)ct+90f (Stewart and Denell, 1993)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD7137} NA P{GD16544} NA P{KK107652} NA P{TRiP.HMS00413} NA
Insertions
	Type of insertions Name Expression data insertion of enhancer trap P{lArB}RpS6WG1288 No miscellaneous insertions P{}RpS6air8 NA P{}RpS6hen1 NA
Gene Ontology: Function, Process & Cellular Component ( 9 unique terms )
Terms Based on Experimental Evidence ( 5 terms )
Molecular Function ( 0 terms)
Biological Process
CV term Evidence References
centrosome duplication inferred from mutant phenotype (Müller et al., 2010) mitotic spindle elongation inferred from mutant phenotype (Goshima et al., 2007) mitotic spindle organization inferred from mutant phenotype (Goshima et al., 2007)
Cellular Component
CV term Evidence References
lipid particle inferred from direct assay (Cermelli et al., 2006) ribosome inferred from direct assay (Alonso and Santaren, 2006)
Terms Based on Predictions or Assertions ( 5 terms )
Molecular Function
CV term Evidence References
structural constituent of ribosome inferred from sequence or structural similarity with Saccharomyces RPS6A (FlyBase, 1992-) non-traceable author statement (Spencer, 1992, Stewart, 1994.3.23, Swiss-Prot Project Members, 1992.12.1)
Biological Process
CV term Evidence References
immune response traceable author statement (Kimbrell and Beutler, 2001) translation inferred from sequence or structural similarity with Saccharomyces RPS6A (FlyBase, 1992-) non-traceable author statement (Spencer, 1992, Stewart, 1994.3.23, Swiss-Prot Project Members, 1992.12.1)
Cellular Component
CV term Evidence References
cytosolic small ribosomal subunit inferred from sequence or structural similarity with Saccharomyces RPS6A (FlyBase, 1992-) non-traceable author statement (Spencer, 1992, Stewart, 1994.3.23) ribosome non-traceable author statement (Swiss-Prot Project Members, 1992.12.1)
Sequence Ontology: Class of Gene
	gene   nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Protein-protein
Interacting group Assay References
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions RpS6 allele Gene References RpS6air8 CycE (Brumby et al., 2004)
External Data
Linkouts	DroID - A comprehensive database of gene and protein interactions. • FBgn0261592 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 31700
Orthologs
Genome-wide drosophilid orthologs	Dana\GF21093 Dere\GG17600 Dgri\GH24620 Dmoj\GI11119 Dper\GL18222 Dpse\GA10657 Dsec\GM11965 Dsim\GD16145 Dvir\GJ15976 Dwil\GK25015 Dyak\RpS6
Curated drosophilid orthologs	Dmau\RpS6 (Zeng et al., 2000) Dpse\GA10657   Dsim\RpS6 (Zeng et al., 2000) Dyak\RpS6
Linkouts	OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • PB17494 NV17814 LH16260 ISCW024315 FBgn0068047 FBgn0226974 FBgn0203161 FBgn0187778 FBgn0166906 JGI_V11_230511 FBgn0070713 FBgn0155824 FBgn0133880 FBgn0132076 FBgn0109824 FBgn0098098 FBgn0087460 CPIJ016021 CPIJ014118 CPIJ011287 CPIJ010779 CPIJ000154 CPIJ018780 CPIJ006436 BGIBMGA001501 ACYPI003298 GB18619 AGAP002919 RS6_AEDAE PHUM244160 GLEAN_10830 GLEAN_01281
Stocks & Reagents
Stocks Listed in FlyBase ( 2 )
Bloomington	32418 y1 sc* v1; P{TRiP.HMS00413}attP2
VDRC	v105279 P{KK107652}VIE-260B
Genomic Clones ( 1 )
	BACR39C15 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 394 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	GH04784 LD31286
Other clones	IP19982 TA01224 yak-ad_RpS6
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	AT19484 AT23290 AT25178 AT27174 GH05189 GH06543 GH06844 GH06944 GH11537 GH13493 GH15030 GH15205 GH15417 GH16290 GH17573 GH18856 GH19423 GH19572 GH21043 GH22992 GH24979 GH25215 GH25784 GH25817 GH26312 GH28765 GH28863 GM01708 GM02762 GM02909 GM04681 GM05720 GM06204 GM06273 GM07901 GM10088 GM14036 GM15039 GM15379 GM16548 GM19918 GM22090 GM22220 GM23203 GM23724 GM24741 GM25766 GM28811 GM30729 GM30879 GM32239 GM32291 GM32346 HL06640 LD10635 LD20828 LD20910 LD21621 LD23352 LD23691 LD24804 LD26679 LD27195 LD31611 LD31818 LD32546 LD32582 LD34633 LD35255 LD35503 LD36312 LD36447 LD36550 LD38449 LD39649 LD39724 LD40748 LD41255 LD41595 LD41617 LD42582 LD42682 LD43426 LD47259 LD47352 LD47676 LP04908 LP04934 LP05677 LP05964 LP07776 LP08623 LP10301 LP10415 LP10856 LP12253 LP13308 LP13973 LP15167 LP18239 LP19751 LP24496 RE03867 RE06320 RE09849 RE15825 RE29644 RE33293 RE34229 RE35856 RE40538 RE47130 RE49460 RE51360 RE53743 RH12380 RH13558 RH13867 RH18177 RH20257 RH25368 RH28833 RH29005 RH33114 RH36753 RH37661 RH40879 RH46243 RH46475 RH57690 RH61436 RH70419 RH74782 SD07718 SD11130 SD11468 SD11807 SD12857 SD13066 SD13476 SD13537 SD13841 SD15081 SD15405 SD15958 SD17058 SD18446 SD19028 SD19865 SD19991 SD20563 SD22541 SD22792 SD23546 SD23759 SD24178 SD24592 SD27137 SD28079
Other clones	14827 51054 67310 81181 103748 121126 144656 282064 295090 473606 522131 522140 523060 524214 528022 533619 542566 542657 556936 557034 557152 557728 569592 569951 575621 576525 576527 bs60d02 CK01.2C.E2 CK01.33B.D10 CK01.90D.H11 Dmel_dig_000070_0643_3745 Dmel_dig_000283_0666_3619 Dmel_dig_000887_0649_0330 Dmel_dig_001165_0665_0296 Dmel_dig_001167_0693_2875 Dmel_dig_001949_0593_3625 Dmel_dig_001965_0687_0685 Dmel_dig_002079_0601_3728 Dmel_dig_002118_0719_0834 Dmel_dig_002828_0697_3468 Dmel_dig_002991_0717_1228 Dmel_dig_003887_0660_1491 Dmel_dig_004257_0712_0775 Dmel_dig_004805_0649_3539 Dmel_dig_004817_0660_0753 Dmel_dig_005032_0710_2506 Dmel_dig_005498_0616_0846 Dmel_dig_005531_0702_2596 Dmel_dig_006208_0620_1576 Dmel_dig_006320_0698_2420 Dmel_dig_006965_0585_2618 Dmel_dig_007328_0670_2521 Dmel_dig_007358_0709_1661 Dmel_dig_007399_0642_3201 Dmel_dig_007481_0588_2714 Dmel_dig_007574_0636_2685 Dmel_dig_007585_0661_3303 Dmel_dig_007785_0642_2208 Dmel_dig_008025_0715_1160 Dmel_dig_008776_0586_1341 Dmel_dig_009096_0594_2139 Dmel_dig_009712_0664_0659 Dmel_dig_010233_0707_2414 Dmel_dig_010693_0601_0698 Dmel_dig_010791_0602_2115 Dmel_dig_010936_0598_2524 Dmel_dig_011038_0630_1222 Dmel_dig_011414_0618_0546 Dmel_dig_011688_0694_0806 Dmel_dig_012041_0603_0568 Dmel_dig_012281_0599_0456 Dmel_dig_012641_0602_1522 Dmel_dig_014522_0673_1229 Dmel_dig_014680_0660_2470 Dmel_dig_014705_0705_3026 Dmel_dig_015042_0717_1630 Dmel_dig_015291_0584_1582 Dmel_dig_015955_0692_1268 Dmel_dig_017624_0690_3312 Dmel_dig_017871_0652_2763 Dmel_dig_018226_0645_3041 Dmel_dig_018285_0583_3070 Dmel_dig_018778_0635_2432 Dmel_dig_019035_0708_1424 Dmel_dig_019534_0707_3116 Dmel_neb_002195_0897_0282 Dmel_neb_002962_0595_3632 Dmel_neb_004833_0912_3510 Dmel_neb_007472_0950_3669 Dmel_neb_007852_0344_2803 Dmel_neb_008066_0933_2672 Dmel_neb_008404_0104_3412 Dmel_neb_008685_0410_3511 Dmel_neb_010056_0864_1892 Dmel_neb_010646_0610_1069 Dmel_neb_011865_0361_0690 Dmel_neb_012722_0666_2279 Dmel_neb_012850_0153_3391 Dmel_neb_012877_0148_1431 Dmel_neb_013448_0428_2961 Dmel_neb_013859_0631_0807 Dmel_neb_014015_0938_2735 Dmel_neb_014051_0636_2245 Dmel_neb_014981_0695_3230 Dmel_neb_015291_0895_0899 Dmel_neb_015524_0597_0516 Dmel_neb_015882_0667_1033 EC02024 EC23816 EC25653 EC30116 EC30280 EC051350 EC052772 EC053119 EK097009 EK117539 EK123003 EK177259 EK195457 EK214627 EK252020 EK307234 EN01428 EN01437 EN03331 EN04957 EN08242 EN09854 EN10203 EN10853 EN11042 EN11148 EN11725 EN11912 EN12142 EN12262 EN15217 EN15505 EN17432 EN17843 EN17846 ESG0111a.B21_D10 ESG0113c.B21_G01 ESG0114c.B21_H08 ESG0118d.B21_F03 FGC006A07 FGC032A02 FGH120C10 FGH128F12 FGM001E04 FGM001G05 FGM002C07 FGM003F11 FGM207H02 FGM210C08 FGM212G05 FGM215C12 FGM216H09 FGM226E02 FGM231C02 FGM231E01 FGM232A12 FGM235E07 FGM237F11 FGM302C05 FGM306F11 FGM309C08 FGM320H08 GH03251 GH13640 GH18754 GH24278 HL01739 HL02302 HL05342 IP09952 IP10021 IP13181 IP13208 IP14744 LD01701 LD02428 LD02685 LD05830 LD06128 LD11864 LD14002 LD19347 LD21157 LD22458 LD23258 LD32457 LP03645 RC0-DA0001-120700-021-G05 RC0-DL0001-140700-022-F03 RC0-DL0001-140700-023-C06 RC0-DL0001-140700-023-H12 RC0-DL0001-140700-026-A09 RC0-DL0001-140700-028-B01 RC0-DL0001-140700-211-G03 RE05244 RE20360 RE25755 RE28678 RE46775 RH28035 RH29078 RH30625 RH33429 RH35502 RH35544 RH36734 RH36790 RH47754 RH63233 RH69564 RP003168705 RP003245550 RP003335271 RP003483222 SD15208 UT01285 UT01917 UUGC0165 UUGC0414 UUGC0416 UUGC0420 UUGC0794
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0261592 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 31700 45993 47871
Antibody Information
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of	Source for identity of: RpS6 CG10944 (Zhang, 1999.11)
Source for database merge of	Source for merge of: RpS6 anon-WO02059370.61 (FlyBase, 1996-) Source for merge of: RpS6 M(1)7BC M(1)7C (Marygold et al., 2007)
Additional comments	Source for merge of RpS6 anon-WO02059370.61 was sequence comparison (date:051113). (FlyBase, 1996-)
Other Comments
	RNAi screen using dsRNA made from templates generated with primers directed against this gene results in aberrantly short, monopolar spindles when assayed in S2 cells. This phenotype can be observed when the screen is performed with or without Cdc27 dsRNA. (Goshima et al., 2007) Minute gene. (Marygold et al., 2007) Deletions removing RpS6 but no other cytoplasmic ribosomal protein-encoding genes show Minute phenotypes. (Marygold et al., 2007) Molecularly-defined mutations in RpS6 result in Minute phenotypes. (Marygold et al., 2007) Expression of transcript changes with adult age. (Shikama and Brack, 1996) Mutants display a blood cell neoplastic phenotype. (Mechler, 1994) Isolated from a Drosophila embryonic cDNA library using a human S6 cDNA as a probe, under intermediate stringency conditions. (Spencer and Mackie, 1993) An RpS6 cDNA has been cloned and sequenced. (Spencer and Mackie, 1993) Genetic and molecular analysis of RpS6 and phenotypic characterisation of two lethal mutations which result in hypertrophy of the larval haematopoietic organs because of overproliferation and aberrant development of haemocytes. (Stewart and Denell, 1993) Comparison of cDNA with genomic DNA identifies a transcription unit including three exons. Two tandem repeats downstream of this transcription unit reiterate divergent copies of the third exon and flanking regions. Comparison of these three repeats with respect to nucleotide sequence shows they clearly arose via a duplication and subsequent crossing over between misaligned copies. Although no direct evidence exists that the downstream exons are transcribed the maintenance of open reading frames in spite of extensive genetic changes is consistent with a protein-coding function. (Stewart and Denell, 1993) When mutated RpS6 causes overproliferation of the larval haemopoietic cells, tumour formation and an increase in the nuclear DNA content of haemopoietic cells. (Stewart and Denell, 1992) Mutations cause overgrowth of lymph glands, abnormal blood cell differentiation, melanotic tumour formation, delayed larval growth, larval organ development retardation and larval death. Clonal analysis reveals wild type RpS6 required for clone survival in germ line and imaginal discs. Regulatory role of RpS6 in the hematopoeitic system may be related to its developmentally regulated phosphorylation. (Watson et al., 1992) A deficiency chromosome that removes RpS14A and RpS14B does not display the Minute phenotype associated with the M(1)7C locus: RpS14A and RpS14B do not correspond to the M(1)7C locus. (Dorer et al., 1991) Mutations that exhibit melanotic tumor phenotypes have been initially characterized. (Watson et al., 1991) Deficiency mapping suggests that M(1)7C, a novel minute locus, is in the same region as RpS14A and RpS14B. (Andersson and Lambertsson, 1990) Dysgenic revertants were generated using jumpstarter mutagenesis for P-element excision.   One of a class of genes (see MIN record) that when present in one, rather than two, copies, produce a characteristic phenotype consisting of short slender bristles and delayed development.
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_078518 NM_167136 RefSeq (Proteins) • NP_511073 NP_727213 DDBJ / EMBL / GenBank • AA951028 AAA28871 AAB05982 AAB05983 AAB05984 AAB05985 AAC34306 AAF46288 AAL13849 AAN09218 AW943078 AX664487 AY058620 L01658 L02074 L02075 L07881 Entrez Gene - A searchable database of RefSeq genes. • 31700 UniProtKB/Swiss-Prot • P29327 UniProtKB/TrEMBL • Q95TP9
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Ribosomal protein S6e, conserved site (IPR018282) Ribosomal protein S6e (IPR001377) Ribosomal protein S6, eukaryotic (IPR014401)
Linkouts
	DroID - A comprehensive database of gene and protein interactions. • FBgn0261592 DRSC - Results from RNAi screens. • FBgn0261592 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0004922 FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0261592 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 31700 45993 47871 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 31700 modMine - Data generated by the modENCODE project. • FBgn0261592 OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • PB17494 NV17814 LH16260 ISCW024315 FBgn0068047 FBgn0226974 FBgn0203161 FBgn0187778 FBgn0166906 JGI_V11_230511 FBgn0070713 FBgn0155824 FBgn0133880 FBgn0132076 FBgn0109824 FBgn0098098 FBgn0087460 CPIJ016021 CPIJ014118 CPIJ011287 CPIJ010779 CPIJ000154 CPIJ018780 CPIJ006436 BGIBMGA001501 ACYPI003298 GB18619 AGAP002919 RS6_AEDAE PHUM244160 GLEAN_10830 GLEAN_01281
Synonyms & Secondary IDs ( 28 )
Reported As
Symbol Synonym	(Rp)S6 (Rosby et al., 2009) air8 (Potter et al., 2000, Bryant, 1993, Watson et al., 1994, Bryant et al., 1993) air8 (Hoffmann and Reichhart, 1997) anon-WO02059370.61   CG10944 (Marygold et al., 2007, Arbeitman et al., 2004, Whitfield, 2000.12.19, Stewart, 2000.4.7, Cermelli et al., 2006, Huang et al., 2005, Goshima et al., 2007, Emberly et al., 2008, Larschan et al., 2007, Worringer et al., 2009, Keleman et al., 2009.8.5, Zhan et al., 2011, Ni et al., 2010.12.1, Cammarato et al., 2011) DS6 (Radimerski et al., 2000) hen (Stewart and Denell, 1992, Stewart and Denell, 1993, ) l(1)air8 (Watson and Bryant, 1991, Watson et al., 1991, ) l(1)air8 (Mechler, 1994) l(1)hen   M(1)7BC (Marygold et al., 2007, ) M(1)7C (Marygold et al., 2007, ) pp30 (Won et al., 1999) RpS6 (Marygold et al., 2007, Cermelli et al., 2006, Goshima et al., 2007, Lawniczak and Begun, 2004, Secombe et al., 2007, Isogai et al., 2007, Pierce et al., 2008, Chittaranjan et al., 2009, Alvarez-Ponce et al., 2009, Worringer et al., 2009, Nie et al., 2009, Rosby et al., 2009, Zhou et al., 2008, Delanoue et al., 2010) rps6 (Watson, 1993.1.27) rpS6 (Dearolf, 1998, Gateff, 1994, Stewart and Denell, 1993, Ruvinsky, 2006) RPS6 (Kaplan et al., 2008, Pinnola et al., 2007) Rps6 (Hill-Burns and Clark, 2009) Rp S6 (Alonso and Santaren, 2006) S6 (Thomas, 2000, Edgar, 1999, Spencer and Mackie, 1993, Watson et al., 1992, Rosby et al., 2009)
Name Synonym	hemocytes enlarged   lethal(1)aberrant immune response8 (Kimbrell and Beutler, 2001) lethal-(1)-haemocytes enlarged   lethal-aberrant-immune-response-8   Minute   Minute (1) 7BC   ribosomal protein S6 (Stewart, 1994.3.23, Stewart, 1994.3.23, Spencer, 1992) Ribosomal protein S6 (Cammarato et al., 2011)
Secondary FlyBase IDs
	FBgn0002584 FBgn0002585 FBgn0004371 FBgn0004388 FBgn0004405 FBgn0004922 FBgn0005276 FBgn0065997
References ( 86 )
Generate a list of	All references relating to this gene ( 86 )
List References by type	Research paper  ( 39 ) Supplementary material  ( 5 ) Review  ( 15 ) Personal communication to FlyBase  ( 5 ) Abstract  ( 9 ) FlyBase analysis  ( 2 ) DNA/RNA sequence record  ( 4 ) Curated genome annotation  ( 2 ) Patent  ( 1 ) Protein sequence record  ( 1 ) Computer file  ( 1 ) Automatic genome annotation  ( 1 ) Book  ( 1 )
Recent research papers ( 4 )
	Booker et al., 2011, BMC Genomics 12: 50 False negative rates in Drosophila cell-based RNAi screens: a case study. [FBrf0212969] Zhan et al., 2011, Gene 470(1-2): 1--6 Evolution of alternative splicing in newly evolved genes of Drosophila. [FBrf0212278] Delanoue et al., 2010, Dev. Cell 18(6): 1012--1021 The steroid hormone ecdysone controls systemic growth by repressing dMyc function in Drosophila fat cells. [FBrf0211284] Müller et al., 2010, EMBO J. 29(19): 3344--3357 Proteomic and functional analysis of the mitotic Drosophila centrosome. [FBrf0212030] Show all research papers ...
Recent reviews (0)
	All reviews listed in FlyBase were published before 2010 Show reviews ...