FlyBase Gene Report: Dmel\RpS26

General Information

Symbol

Dmel\RpS26

Species

D. melanogaster

Name

Ribosomal protein S26

Annotation Symbol

CG10305

Feature Type

protein_coding_gene

FlyBase ID

FBgn0261597

Gene Model Status

Current

Stock Availability

10 publicly available

Gene Summary

Contribute a Gene Snapshot for this gene.

All Summaries

Alliance
Auto summary
Gene Group
Red Book
Interactive Fly

Also Known As

M(2)m, l(2)04553, M(2)36F

Key Links

Genomic Location

Cytogenetic map

36F4-36F4

Sequence location

2L:18,441,335..18,443,277 [-]

Recombination map

2-53

RefSeq locus

NT_033779 REGION:18441335..18443277

Sequence

Get Decorated FASTA

Genomic Maps

JBrowse

Other Genome Views

The following external sites may use different assemblies or annotations than FlyBase.

Function

Gene Ontology (GO) Annotations (8 terms)

Molecular Function (2 terms)

Terms Based on Experimental Evidence (1 term)

CV Term

Evidence

References

enables structural constituent of ribosome

inferred from direct assay

(Anger et al., 2013)

Terms Based on Predictions or Assertions (2 terms)

CV Term

Evidence

References

enables mRNA binding

inferred from biological aspect of ancestor with PANTHER:PTN000283756

(GO Reference Genome Project, 2011-)

enables structural constituent of ribosome

inferred from electronic annotation with InterPro:IPR000892

(InterPro Project Members, 2004-)

traceable author statement

(Marygold et al., 2007)

inferred from biological aspect of ancestor with PANTHER:PTN000283756

(GO Reference Genome Project, 2011-)

Biological Process (2 terms)

Terms Based on Experimental Evidence (0 terms)

Terms Based on Predictions or Assertions (2 terms)

CV Term

Evidence

References

involved_in cytoplasmic translation

traceable author statement

(Marygold et al., 2007)

inferred from sequence or structural similarity with UniProtKB:P62854

(Gene Ontology Curators, 2002-)

inferred by curator from GO:0022626

(Anger et al., 2013)

involved_in translation

inferred from electronic annotation with InterPro:IPR000892

(InterPro Project Members, 2004-)

Cellular Component (4 terms)

Terms Based on Experimental Evidence (2 terms)

CV Term

Evidence

References

located_in cytosolic ribosome

inferred from direct assay

(Anger et al., 2013)

part_of cytosolic small ribosomal subunit

inferred from direct assay

(Anger et al., 2013)

Terms Based on Predictions or Assertions (3 terms)

CV Term

Evidence

References

located_in cytoplasmic side of rough endoplasmic reticulum membrane

inferred from sequence or structural similarity with UniProtKB:P49171

(Gene Ontology Curators, 2002-)

part_of cytosolic small ribosomal subunit

traceable author statement

(Marygold et al., 2007)

inferred from biological aspect of ancestor with PANTHER:PTN000283756

(GO Reference Genome Project, 2011-)

located_in ribosome

inferred from electronic annotation with InterPro:IPR000892

(InterPro Project Members, 2004-)

inferred from sequence or structural similarity with UniProtKB:P62854

(Gene Ontology Curators, 2002-)

Gene Group (FlyBase)

CYTOPLASMIC SMALL RIBOSOMAL SUBUNIT

CYTOPLASMIC SMALL RIBOSOMAL SUBUNIT - TESTIS-SPECIFIC VARIANT

Protein Family (UniProt)

Belongs to the eukaryotic ribosomal protein eS26 family. (P13008)

Protein Signatures (InterPro)

Summaries

Gene Group (FlyBase)

CYTOPLASMIC SMALL RIBOSOMAL SUBUNIT -: Cytoplasmic ribosomes are found on the endoplasmic reticulum and in the cytosol. They translate all mRNAs produced from nuclear genes and perform the majority of cellular protein synthesis. Ribosomes are formed by two ribonucleoprotein subunits, large and small. The principle function of the small subunit is to bind mRNA. (Adapted from FBrf0205398.)
CYTOPLASMIC SMALL RIBOSOMAL SUBUNIT - TESTIS-SPECIFIC VARIANT -: Cytoplasmic ribosomes are found on the endoplasmic reticulum and in the cytosol. They translate all mRNAs produced from nuclear genes and perform the majority of cellular protein synthesis. Ribosomes are formed by two ribonucleoprotein subunits, large and small. The principle function of the small subunit is to bind mRNA. Tissue expression data from modENCODE has been used to infer the composition of the cytosolic small ribosomal subunit testis-specific variant. (Adapted from FBrf0205398.)

Phenotypic Description (Red Book; Lindsley and Zimm 1992)

M(2)36F

Medium to strong Minute. Eclosion of heterozygous deficiency delayed 30 hr (Ferrus, 1975, Genetics 79: 589-99).

Gene Model and Products

Number of Transcripts

Number of Unique Polypeptides

Please see the JBrowse view of Dmel\RpS26 for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)

Isoform displayed:

Pfam protein domains

InterPro name

classification

start

end

Protein Domains (via SMART)

Isoform displayed:

SMART protein domains

InterPro name

classification

start

end

Structure

Protein 3D structure (Predicted by AlphaFold) (AlphaFold entry P13008)

If you don't see a structure in the viewer, refresh your browser.

Model Confidence:

Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Experimentally Determined Structures

Crossreferences

PDB - An information portal to biological macromolecular structures

Comments on Gene Model

Gene model reviewed during 5.56

Gene model reviewed during 5.44

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Assoc. CDS (aa)

RpS26-RA

FBtr0081089

NM_165252

640

114

RpS26-RB

FBtr0081090

NM_078871

692

114

RpS26-RC

FBtr0081091

NM_165253

1112

114

RpS26-RD

FBtr0331455

NM_001273608

1046

114

RpS26-RE

FBtr0346591

NM_001299113

1812

114

Additional Transcript Data and Comments

Reported size (kB)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kDa)

Length (aa)

Theoretical pI

UniProt

RefSeq ID

GenBank

RpS26-PA

FBpp0080639

13.3

114

11.73

FBpp0080640

13.3

114

11.73

FBpp0080641

13.3

114

11.73

FBpp0303872

13.3

114

11.73

FBpp0312181

13.3

114

11.73

P13008

NP_001286042

AHN54556

Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

114 aa isoforms: RpS26-PA, RpS26-PB, RpS26-PC, RpS26-PD, RpS26-PE

Additional Polypeptide Data and Comments

Reported size (kDa)

Comments

External Data

Subunit Structure (UniProtKB)

Component of the 40S small ribosomal subunit.

(UniProt, P13008)

Crossreferences

InterPro - A database of protein families, domains and functional sites

PDB - An information portal to biological macromolecular structures

Linkouts

Sequences Consistent with the Gene Model

Nucleotide / Polypeptide Records

UniProt

Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\RpS26 using the Feature Mapper tool.

External Data

Crossreferences

Linkouts

Expression Data

Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

-0.74

Transcript Expression

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Polypeptide Expression

mass spectroscopy

Stage

Tissue/Position (including subcellular localization)

Reference

adult stage

adult head

• membrane

(Aradska et al., 2015)

day 7 of adulthood -- day 49 of adulthood

adult heart

(Cammarato et al., 2011)

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Evidence

References

located_in cytosolic ribosome

inferred from direct assay

(Anger et al., 2013)

part_of cytosolic small ribosomal subunit

inferred from direct assay

(Anger et al., 2013)

Expression Deduced from Reporters

High-Throughput Expression Data

Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\RpS26 in JBrowse

RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region

View exonic expression by developmental stage for Dmel\RpS26

View exonic expression by tissue for Dmel\RpS26

Bulk Downloads

RNA-Seq RPKM values for all genes

Reference

See Gelbart and Emmert, 2013 for analysis details and data files for all genes.

Developmental Proteome: Life Cycle

Developmental Proteome: Embryogenesis

External Data and Images

Linkouts

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

35098/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0261597

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0004413

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0261597

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG10305

Images

FlyBase Wiki

Image Based Resources

Alleles, Insertions, Transgenic Constructs, and Aberrations

Classical and Insertion Alleles ( 9 )

For All Classical and Insertion Alleles Show

Other relevant insertions

Transgenic Constructs ( 7 )

For All Alleles Carried on Transgenic Constructs Show

Transgenic constructs containing/affecting coding region of RpS26

Transgenic constructs containing regulatory region of RpS26

Aberrations (Deficiencies and Duplications) ( 34 )

Inferred from experimentation ( 34 )

Gene duplicated in

Dp(2;2)M(2)m⁺

(Wright, 1995.12.1)

Dp(2;Y)G-M15

(Contamine et al., 1989)

Gene not duplicated in

Dp(2;Y)H

Inferred from location ( 5 )

Variants

Variant Molecular Consequences

Alleles Representing Disease-Implicated Variants

Phenotypes

For more details about a specific phenotype click on the relevant allele symbol.

Lethality

Allele

lethal, with Scer\GAL4^pnr-MD237

RpS26^GD6933

lethal | recessive

partially lethal, with Scer\GAL4^tin.CΔ4

RpS26^GD6933

viable, with Dcr-2^UAS.cDa, Scer\GAL4^elav.PLu

RpS26^GD6933

Other Phenotypes

Allele

decreased body size | larval stage

RpS26^unspecified

increased cell death | cell autonomous | larval stage | somatic clone - tissue specific

RpS26^cKO

Minute

Minute | dominant

Phenotype manifest in

Allele

imaginal disc posterior compartment | cell autonomous | somatic clone - tissue specific

RpS26^cKO

Orthologs

Downloads

Download All DIOPT Orthologs

Human Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Homo sapiens (Human) (3)

Hsap\RPS26

12 of 14

Yes

Hsap\RPS26P11

9 of 14

Yes

Hsap\LOC100996747

1 of 14

Yes

Model Organism Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Rattus norvegicus (Norway rat) (10)

Rnor\LOC100361854

13 of 14

Yes

Rnor\LOC100360508

12 of 14

Yes

Rnor\RGD1559808

12 of 14

Yes

Rnor\Rps26

12 of 14

Yes

Rnor\LOC688948

11 of 14

Yes

Rnor\RGD1562415

11 of 14

Yes

Rnor\RGD1565117

11 of 14

Yes

Rnor\LOC100363142

7 of 14

Yes

Rnor\LOC100361756

1 of 14

Yes

Rnor\LOC108349054

1 of 14

Yes

Mus musculus (laboratory mouse) (1)

Mmus\Rps26

13 of 14

Yes

Xenopus tropicalis (Western clawed frog) (1)

Xtro\rps26

8 of 13

Yes

Danio rerio (Zebrafish) (2)

Drer\rps26l

14 of 14

Yes

Drer\rps26

13 of 14

Yes

Caenorhabditis elegans (Nematode, roundworm) (1)

Cele\rps-26

14 of 14

Yes

Anopheles gambiae (African malaria mosquito) (1)

Agam\RS26_ANOGA

12 of 12

Yes

Arabidopsis thaliana (thale-cress) (3)

Atha\AT2G40510

13 of 13

Yes

Atha\AT2G40590

13 of 13

Yes

Atha\AT3G56340

13 of 13

Yes

Saccharomyces cerevisiae (Brewer's yeast) (2)

Scer\RPS26A

13 of 13

Yes

Scer\RPS26B

13 of 13

Yes

Schizosaccharomyces pombe (Fission yeast) (2)

Spom\rps2601

12 of 12

Yes

Spom\rps2602

12 of 12

Yes

Escherichia coli (enterobacterium) (0)

Other Organism Orthologs (via OrthoDB)

Data provided directly from OrthoDB:RpS26. Refer to their site for version information.

Paralogs

Downloads

Download All DIOPT Paralogs

Paralogs (via DIOPT v9.1)

Gene Symbol

Score

Source

Alignment

Drosophila melanogaster (Fruit fly) (0)

Human Disease Associations

FlyBase Human Disease Model Reports

cardiomyopathy (postulated), translation-critical genes

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 1 )

Allele

Disease

Evidence

References

RpS26^cKO

model of Diamond-Blackfan anemia

CEA

(Recasens-Alvarez et al., 2021)

Potential Models Based on Orthology ( 1 )

Human Ortholog

Disease

Evidence

References

RPS26; ribosomal protein S26

model of Diamond-Blackfan anemia 10

IEA

(FlyBase, 2019-)

Modifiers Based on Experimental Evidence ( 0 )

Allele

Disease

Interaction

References

Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)

Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.

Homo sapiens (Human)

Gene name

Score

OMIM

OMIM Phenotype

DO term

Complementation?

Transgene?

RPS26; ribosomal protein S26

12 of 14

603701

DIAMOND-BLACKFAN ANEMIA 10; DBA10

Diamond-Blackfan anemia 10

RPS26P11; ribosomal protein S26 pseudogene 11

9 of 14

Functional Complementation Data

Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.

Interactions

Summary of Physical Interactions

Interaction Browsers

View in FlyBase Interactions Browser View in MIST tool (external link)

Please see the Physical Interaction reports below for full details

protein-protein

Physical Interaction

Assay

References

RpS26 - Pdk1

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

RpS26 - Pi3K92E

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

RpS26 - Rack1

cosedimentation, electron microscopy

(Anger et al., 2013)

RpS26 - Raf

anti tag coimmunoprecipitation, peptide massfingerprinting

(Friedman et al., 2011)

RpS26 - RpL10

cosedimentation, Identification by mass spectrometry, electron microscopy

(Anger et al., 2013)

RpS26 - RpL10Ab

cosedimentation, Identification by mass spectrometry, electron microscopy

(Anger et al., 2013)

RpS26 - RpL11

cosedimentation, Identification by mass spectrometry, electron microscopy

(Anger et al., 2013)

RpS26 - RpL12

cosedimentation, Identification by mass spectrometry, electron microscopy

(Anger et al., 2013)

RpS26 - RpL13

cosedimentation, Identification by mass spectrometry, electron microscopy

(Anger et al., 2013)

RpS26 - RpL13A

cosedimentation, Identification by mass spectrometry, electron microscopy

(Anger et al., 2013)

RpS26 - RpL14

cosedimentation, Identification by mass spectrometry, electron microscopy

(Anger et al., 2013)

RpS26 - RpL15

cosedimentation, Identification by mass spectrometry, electron microscopy

(Anger et al., 2013)

RpS26 - RpL17

cosedimentation, Identification by mass spectrometry, electron microscopy

(Anger et al., 2013)

RpS26 - RpL18

cosedimentation, Identification by mass spectrometry, electron microscopy

(Anger et al., 2013)

RpS26 - RpL18A

cosedimentation, Identification by mass spectrometry, electron microscopy

(Anger et al., 2013)

RpS26 - RpL19

cosedimentation, Identification by mass spectrometry, electron microscopy

(Anger et al., 2013)

RpS26 - RpL21

cosedimentation, Identification by mass spectrometry, electron microscopy

(Anger et al., 2013)

RpS26 - RpL22

cosedimentation, Identification by mass spectrometry, electron microscopy

(Anger et al., 2013)

RpS26 - RpL23

cosedimentation, Identification by mass spectrometry, electron microscopy

(Anger et al., 2013)

RpS26 - RpL23A

cosedimentation, Identification by mass spectrometry, electron microscopy

(Anger et al., 2013)

RpS26 - RpL24

cosedimentation, Identification by mass spectrometry, electron microscopy

(Anger et al., 2013)

RpS26 - RpL26

cosedimentation, Identification by mass spectrometry, electron microscopy

(Anger et al., 2013)

RpS26 - RpL27

cosedimentation, Identification by mass spectrometry, electron microscopy

(Anger et al., 2013)

RpS26 - RpL27A

cosedimentation, Identification by mass spectrometry, electron microscopy

(Anger et al., 2013)

RpS26 - RpL28

cosedimentation, Identification by mass spectrometry, electron microscopy

(Anger et al., 2013)

RpS26 - RpL29

cosedimentation, Identification by mass spectrometry, electron microscopy

(Anger et al., 2013)

RpS26 - RpL3

cosedimentation, Identification by mass spectrometry, electron microscopy

(Anger et al., 2013)

RpS26 - RpL30

cosedimentation, Identification by mass spectrometry, electron microscopy

(Anger et al., 2013)

RpS26 - RpL31

cosedimentation, Identification by mass spectrometry, electron microscopy

(Anger et al., 2013)

RpS26 - RpL32

cosedimentation, Identification by mass spectrometry, electron microscopy

(Anger et al., 2013)

RpS26 - RpL34a

cosedimentation, Identification by mass spectrometry, electron microscopy

(Anger et al., 2013)

RpS26 - RpL35

cosedimentation, electron microscopy

(Anger et al., 2013)

RpS26 - RpL35A

cosedimentation, electron microscopy

(Anger et al., 2013)

RpS26 - RpL36

cosedimentation, Identification by mass spectrometry, electron microscopy

(Anger et al., 2013)

RpS26 - RpL36A

cosedimentation, Identification by mass spectrometry, electron microscopy

(Anger et al., 2013)

RpS26 - RpL37-1

cosedimentation, Identification by mass spectrometry, electron microscopy

(Anger et al., 2013)

RpS26 - RpL37A

cosedimentation, Identification by mass spectrometry, electron microscopy

(Anger et al., 2013)

RpS26 - RpL38

cosedimentation, Identification by mass spectrometry, electron microscopy

(Anger et al., 2013)

RpS26 - RpL39

cosedimentation, electron microscopy

(Anger et al., 2013)

RpS26 - RpL4

cosedimentation, Identification by mass spectrometry, electron microscopy

(Anger et al., 2013)

RpS26 - RpL40

cosedimentation, electron microscopy

(Anger et al., 2013)

RpS26 - RpL41

cosedimentation, electron microscopy

(Anger et al., 2013)

RpS26 - RpL5

cosedimentation, Identification by mass spectrometry, electron microscopy

(Anger et al., 2013)

RpS26 - RpL6

cosedimentation, Identification by mass spectrometry, electron microscopy

(Anger et al., 2013)

RpS26 - RpL7

cosedimentation, Identification by mass spectrometry, electron microscopy

(Anger et al., 2013)

RpS26 - RpL7A

cosedimentation, Identification by mass spectrometry, electron microscopy

(Anger et al., 2013)

RpS26 - RpL8

cosedimentation, Identification by mass spectrometry, electron microscopy

(Anger et al., 2013)

RpS26 - RpL9

cosedimentation, Identification by mass spectrometry, electron microscopy

(Anger et al., 2013)

RpS26 - RpLP0

cosedimentation, Identification by mass spectrometry, electron microscopy

(Anger et al., 2013)

RpS26 - RpLP1

cosedimentation, Identification by mass spectrometry, electron microscopy

(Anger et al., 2013)

RpS26 - RpLP2

cosedimentation, Identification by mass spectrometry, electron microscopy

(Anger et al., 2013)

RpS26 - RpS10a

cosedimentation, Identification by mass spectrometry, electron microscopy

(Anger et al., 2013)

RpS26 - RpS11

cosedimentation, Identification by mass spectrometry, electron microscopy

(Anger et al., 2013)

RpS26 - RpS12

cosedimentation, Identification by mass spectrometry, electron microscopy

(Anger et al., 2013)

RpS26 - RpS13

cosedimentation, Identification by mass spectrometry, electron microscopy

(Anger et al., 2013)

RpS26 - RpS14a

cosedimentation, Identification by mass spectrometry, electron microscopy

(Anger et al., 2013)

RpS26 - RpS14b

cosedimentation, Identification by mass spectrometry, electron microscopy

(Anger et al., 2013)

RpS26 - RpS15

cosedimentation, Identification by mass spectrometry, electron microscopy

(Anger et al., 2013)

RpS26 - RpS15Aa

cosedimentation, Identification by mass spectrometry, electron microscopy

(Anger et al., 2013)

RpS26 - RpS16

cosedimentation, Identification by mass spectrometry, electron microscopy

(Anger et al., 2013)

RpS26 - RpS17

cosedimentation, Identification by mass spectrometry, electron microscopy

(Anger et al., 2013)

RpS26 - RpS18

cosedimentation, Identification by mass spectrometry, electron microscopy

(Anger et al., 2013)

RpS26 - RpS19a

cosedimentation, Identification by mass spectrometry, electron microscopy

(Anger et al., 2013)

RpS26 - RpS2

cosedimentation, Identification by mass spectrometry, electron microscopy

(Anger et al., 2013)

RpS26 - RpS20

cosedimentation, Identification by mass spectrometry, electron microscopy

(Anger et al., 2013)

RpS26 - RpS21

cosedimentation, Identification by mass spectrometry, electron microscopy

(Anger et al., 2013)

RpS26 - RpS23

cosedimentation, Identification by mass spectrometry, electron microscopy

(Anger et al., 2013)

RpS26 - RpS24

cosedimentation, Identification by mass spectrometry, electron microscopy

(Anger et al., 2013)

RpS26 - RpS25

cosedimentation, Identification by mass spectrometry, electron microscopy

(Anger et al., 2013)

RpS26 - RpS27

cosedimentation, Identification by mass spectrometry, electron microscopy

(Anger et al., 2013)

RpS26 - RpS27A

cosedimentation, Identification by mass spectrometry, electron microscopy

(Anger et al., 2013)

RpS26 - RpS28b

cosedimentation, Identification by mass spectrometry, electron microscopy

(Anger et al., 2013)

RpS26 - RpS29

cosedimentation, Identification by mass spectrometry, electron microscopy

(Anger et al., 2013)

RpS26 - RpS3

cosedimentation, Identification by mass spectrometry, electron microscopy

(Anger et al., 2013)

RpS26 - RpS30

cosedimentation, electron microscopy

(Anger et al., 2013)

RpS26 - RpS3A

cosedimentation, Identification by mass spectrometry, electron microscopy

(Anger et al., 2013)

RpS26 - RpS4

cosedimentation, Identification by mass spectrometry, electron microscopy

(Anger et al., 2013)

RpS26 - RpS5a

cosedimentation, Identification by mass spectrometry, electron microscopy

(Anger et al., 2013)

RpS26 - RpS6

cosedimentation, Identification by mass spectrometry, electron microscopy

(Anger et al., 2013)

RpS26 - RpS7

cosedimentation, Identification by mass spectrometry, electron microscopy

(Anger et al., 2013)

RpS26 - RpS8

cosedimentation, Identification by mass spectrometry, electron microscopy

(Anger et al., 2013)

RpS26 - RpS9

cosedimentation, Identification by mass spectrometry, electron microscopy

(Anger et al., 2013)

RpS26 - chico

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

RpS26 - eEF2

cosedimentation, Identification by mass spectrometry, electron microscopy

(Anger et al., 2013)

RpS26 - foxo

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

RpS26 - sta

cosedimentation, Identification by mass spectrometry, electron microscopy

(Anger et al., 2013)

RpS26 - vig2

cosedimentation, Identification by mass spectrometry, electron microscopy

(Anger et al., 2013)

RNA-protein

Physical Interaction

Assay

References

RpS26 - 18SrRNA

cosedimentation, electron microscopy

(Anger et al., 2013)

RpS26 - 28SrRNA

cosedimentation, electron microscopy

(Anger et al., 2013)

RpS26 - 2SrRNA

cosedimentation, electron microscopy

(Anger et al., 2013)

RpS26 - 5.8SrRNA

cosedimentation, electron microscopy

(Anger et al., 2013)

RpS26 - 5SrRNA

cosedimentation, electron microscopy

(Anger et al., 2013)

Summary of Genetic Interactions

Interaction Browsers

View in FlyBase Interactions Browser View in MIST tool (external link)

Please look at the allele data for full details of the genetic interactions

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

suppressible

(Ida et al., 2009)

enhanceable

(Coelho et al., 2005)

External Data

Subunit Structure (UniProtKB)

Component of the 40S small ribosomal subunit.

(UniProt, P13008 )

Linkouts

DroID - A comprehensive database of gene and protein interactions.

FBgn0261597

MIST (protein-protein) - An integrated Molecular Interaction Database

35098

Pathways

Signaling Pathways (FlyBase)

Metabolic Pathways

FlyBase

External Links

External Data

Linkouts

KEGG Pathways - A collection of manually drawn pathway maps representing knowledge of molecular interaction, reaction and relation networks.

Ribosome

Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.

Class of Gene

gene

nuclear_gene

protein_coding_gene

Genomic Location and Detailed Mapping Data

Chromosome (arm)

Recombination map

2-53

Cytogenetic map

36F4-36F4

Sequence location

2L:18,441,335..18,443,277 [-]

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

36F4-36F4

Limits computationally determined from genome sequence between P{lacW}Aac11^k06710 and P{EP}CG10413^EP2164

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

36E1-36E4

(determined by in situ hybridisation)

(Spradling et al., 1999)

36E1-36E4

(BDGP Project Members, 1994-1999)

Experimentally Determined Recombination Data

Location

2-53

(FlyBase, 2016)

2-53.3

(Comeron et al., 2012)

2-50

(Schultz, 1929)

2-[53]

Left of (cM)

Right of (cM)

Notes

Stocks and Reagents

Stocks (10)

Aberrations including deletions of this gene Aberrations including duplications of this gene

Bloomington

12048

P{PZ}RpS26⁰⁴⁵⁵³/CyO; ry⁵⁰⁶

78195

y¹ sc^* v¹ sev²¹; P{TOE.GS01370}attP40

33393

y¹ sc^* v¹ sev²¹; P{TRiP.HMS00270}attP2

FlyORF

F001538

M{UAS-RpS26.ORF}ZH-86Fb

F000865

M{UAS-RpS26.ORF.3xHA}ZH-86Fb

Kyoto

114620

y^d2 w¹¹¹⁸ P{ey-FLP.N}2 P{5xglBS-lacZ.38-1}TPN1; P{SUPor-P}RpS26^KG00230 P{neoFRT}40A/CyO y⁺

NIG-Fly

HMS00270

y¹ sc^* v¹ sev²¹; P{TRiP.HMS00270}attP2

2LG-0752

y² VhaAC39-1^cho-1 v¹; P{U6-RpS26.NIG.sgRNA}attP40/CyO

VDRC

v109004

P{KK108888}VIE-260B

v16012

w¹¹¹⁸; P{GD6933}v16012

Genomic Clones (23)

Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

cDNA Clones (575)

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequenced

BDGP DGC clones

RE01079

Other clones

MIP08169

Drosophila Genomics Resource Center cDNA clones

For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

FBgn0261597

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

Other clones

RNAi and Array Information

Linkouts

DRSC - Results frm RNAi screens

FBgn0261597

Antibody Information

Laboratory Generated Antibodies

polyclonal

(Nishiyama et al., 2007)

Commercially Available Antibodies

Cell Line Information

Publicly Available Cell Lines

Other Stable Cell Lines

Other Comments

Minute gene.

(Marygold et al., 2007)

Deletions removing RpS26 but no other cytoplasmic ribosomal protein-encoding genes show Minute phenotypes.

(Marygold et al., 2007)

Molecularly-defined mutations in RpS26 result in Minute phenotypes.

(Marygold et al., 2007)

RNAi generated by PCR using primers directed to this gene causes a cell growth and viability phenotype when assayed in Kc167 and S2R⁺ cells.

(Boutros et al., 2004)

RpS26 has been cloned and sequenced.

(Itoh et al., 1989)

An RpS26 cDNA has been cloned and sequenced.

(Itoh et al., 1989)

One of a class of genes (see MIN record) that when present in one, rather than two, copies, produce a characteristic phenotype consisting of short slender bristles and delayed development. Medium to strong Minute.

Relationship to Other Genes

Source for database merge of

Source for merge of: RpS26 l(2)04553

(Spradling et al., 1999)

Source for merge of: RpS26 anon- EST:fe2A3

(Bayraktaroglu, 2000.11.2)

Source for merge of: RpS26 M(2)36F

(Marygold et al., 2007)

Additional comments

Probably corresponds to RpS26.

(Marygold, 2005.1.19)

Nomenclature History

Source for database identify of

Nomenclature comments

Etymology

Synonyms and Secondary IDs (18)

Reported As

Symbol Synonym

CG10305

(National Institute of Genetics Fly Stocks, 2022-, Schertel et al., 2013, Cammarato et al., 2011, Ni et al., 2010.12.1, Ida et al., 2009, Keleman et al., 2009.8.5, Marygold et al., 2007)

M(2)36F

(Marygold et al., 2007)

M(2)S13

M(2)m

(Rizki et al., 1985, Wright et al., 1981, Wright et al., 1976, Lindsley et al., 1972, Seattle-La Jolla Drosophila Laboratories, 1971)

M_s

(Schultz, 1929)

RPS26

(Recasens-Alvarez et al., 2021)

Rps26

(Karam et al., 2022, Gerber et al., 2006)

S26e

(Anger et al., 2013)

anon-EST:fe2A3

l(2)04553

(Meister and Braun, 1995.10, BDGP Project Members, 1994-1999)

l(2)36Fa

rpS26

(Deliu et al., 2022, Nishiyama et al., 2007)

rpS31

Name Synonyms

Minute (2) 36F

Ribosomal protein S26

(Cammarato et al., 2011)

anon-fast-evolving-2A3

ribosomal protein S31

(Itoh, 1988.11.24)

Secondary FlyBase IDs

FBgn0005520
FBgn0002008
FBgn0002598
FBgn0004413
FBgn0003280
FBgn0004088
FBgn0011775
FBgn0025235

Datasets (0)

Study focus (0)

Experimental Role

Project

Project Type

Title

Study result (0)

Result

Result Type

Title

External Crossreferences and Linkouts ( 62 )

Sequence Crossreferences

NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.

35098

GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.

GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.

RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.

UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.

P13008

UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information

P13008

UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information

M9PG47

Other crossreferences

AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.

P13008

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

35098/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0261597

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0261597

InterPro - A database of protein families, domains and functional sites

KEGG Genes - Molecular building blocks of life in the genomic space.

dme:Dmel_CG10305

MARRVEL_MODEL - MARRVEL (model organism gene)

35098

PDB - An information portal to biological macromolecular structures

Linkouts

Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones

FBgn0261597

DroID - A comprehensive database of gene and protein interactions.

FBgn0261597

DRSC - Results frm RNAi screens

FBgn0261597

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0004413

FlyCyc Genes - Genes from a BioCyc PGDB for Dmel

FBGN0261597

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG10305

FlyMet - A comprehensive tissue-specific metabolomics resource for Drosophila.

FBgn0261597

iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)

TC005984

KEGG Pathways - A collection of manually drawn pathway maps representing knowledge of molecular interaction, reaction and relation networks.

Ribosome

MIST (protein-protein) - An integrated Molecular Interaction Database

35098

Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.

References (100)

The following external sites may use different assemblies or annotations than FlyBase.

-0.74

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