FlyBase Gene Report: Dmel\RpL37A

General Information

Symbol

Dmel\RpL37A

Species

D. melanogaster

Name

Ribosomal protein L37A

Annotation Symbol

CG5827

Feature Type

protein_coding_gene

FlyBase ID

FBgn0261608

Gene Model Status

Current

Stock Availability

5 publicly available

Gene Summary

Contribute a Gene Snapshot for this gene.

All Summaries

Alliance
Auto summary
Gene Group
Red Book
Interactive Fly

Also Known As

M(2)S1, L37A, M(2)25C

Key Links

Genomic Location

Cytogenetic map

25C4-25C4

Sequence location

2L:5,070,957..5,072,055 [+]

Recombination map

2-15

RefSeq locus

NT_033779 REGION:5070957..5072055

Sequence

Get Decorated FASTA

Genomic Maps

JBrowse

Other Genome Views

The following external sites may use different assemblies or annotations than FlyBase.

Function

Gene Ontology (GO) Annotations (6 terms)

Molecular Function (1 term)

Terms Based on Experimental Evidence (1 term)

CV Term

Evidence

References

enables structural constituent of ribosome

inferred from direct assay

(Anger et al., 2013)

Terms Based on Predictions or Assertions (1 term)

CV Term

Evidence

References

enables structural constituent of ribosome

traceable author statement

(Marygold et al., 2007)

inferred from biological aspect of ancestor with PANTHER:PTN008733936

(GO Reference Genome Project, 2011-)

inferred from electronic annotation with InterPro:IPR002674, InterPro:IPR011331

(InterPro Project Members, 2004-)

Biological Process (2 terms)

Terms Based on Experimental Evidence (0 terms)

Terms Based on Predictions or Assertions (2 terms)

CV Term

Evidence

References

involved_in cytoplasmic translation

traceable author statement

(Marygold et al., 2007)

inferred by curator from GO:0022626

(Anger et al., 2013)

involved_in translation

inferred from electronic annotation with InterPro:IPR002674, InterPro:IPR011331, InterPro:IPR011332

(InterPro Project Members, 2004-)

Cellular Component (3 terms)

Terms Based on Experimental Evidence (1 term)

CV Term

Evidence

References

located_in cytosolic ribosome

inferred from direct assay

(Anger et al., 2013)

Terms Based on Predictions or Assertions (3 terms)

CV Term

Evidence

References

part_of cytosolic large ribosomal subunit

traceable author statement

(Marygold et al., 2007)

is_active_in cytosolic ribosome

inferred from biological aspect of ancestor with PANTHER:PTN008733936

(GO Reference Genome Project, 2011-)

located_in ribosome

inferred from electronic annotation with InterPro:IPR002674, InterPro:IPR011331

(InterPro Project Members, 2004-)

Gene Group (FlyBase)

CYTOPLASMIC LARGE RIBOSOMAL PROTEINS

Protein Family (UniProt)

Belongs to the eukaryotic ribosomal protein eL43 family. (Q9VMU4)

Protein Signatures (InterPro)

Summaries

Gene Group (FlyBase)

CYTOPLASMIC LARGE RIBOSOMAL PROTEINS -: Cytoplasmic ribosomes are found on the endoplasmic reticulum and in the cytoplasm. They translate all mRNAs produced from nuclear genes and perform the majority of cellular protein synthesis. Ribosomes are formed by two ribonucleoprotein subunits, large and small. The principle function of the large subunit is to bind tRNA during the synthesis of polypeptides. (Adapted from FBrf0205398).

Phenotypic Description (Red Book; Lindsley and Zimm 1992)

*M(2)25C

Small-bristled Minute with heavy body. Classification good. Viability and fertility fairly good. RK2.

Gene Model and Products

Number of Transcripts

Number of Unique Polypeptides

Please see the JBrowse view of Dmel\RpL37A for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)

Isoform displayed:

Pfam protein domains

InterPro name

classification

start

end

Protein Domains (via SMART)

Isoform displayed:

SMART protein domains

InterPro name

classification

start

end

Structure

Protein 3D structure (Predicted by AlphaFold) (AlphaFold entry Q9VMU4)

If you don't see a structure in the viewer, refresh your browser.

Model Confidence:

Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Experimentally Determined Structures

Crossreferences

PDB - An information portal to biological macromolecular structures

Comments on Gene Model

Low-frequency RNA-Seq exon junction(s) not annotated.

Gene model reviewed during 5.45

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Assoc. CDS (aa)

FBtr0079016

511

FBtr0079017

583

FBtr0302570

705

Additional Transcript Data and Comments

Reported size (kB)

0.5 (northern blot)

(Gaines et al., 1999)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kDa)

Length (aa)

Theoretical pI

UniProt

RefSeq ID

GenBank

RpL37A-PA

FBpp0078655

10.3

11.27

FBpp0078656

10.3

11.27

FBpp0291726

10.3

11.27

Q9VMU4

NP_001188691

ADV36941

Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

92 aa isoforms: RpL37A-PA, RpL37A-PB, RpL37A-PC

Additional Polypeptide Data and Comments

Reported size (kDa)

92 (aa); 10.3 (kD predicted)

(Gaines et al., 1999)

Comments

External Data

Crossreferences

InterPro - A database of protein families, domains and functional sites

PDB - An information portal to biological macromolecular structures

Linkouts

Sequences Consistent with the Gene Model

Nucleotide / Polypeptide Records

UniProt

Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\RpL37A using the Feature Mapper tool.

External Data

Crossreferences

Linkouts

Expression Data

Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

-1.32

Transcript Expression

in situ

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage 1 -- 3

organism | ubiquitous

Comment: maternally deposited

(Fisher et al., 2012)

embryonic stage 4 -- 6

organism | ubiquitous

(Fisher et al., 2012)

embryonic stage 7 -- 8

organism | ubiquitous

(Fisher et al., 2012)

embryonic stage 9 -- 10

organism | ubiquitous

(Fisher et al., 2012)

embryonic stage 11 -- 12

organism | ubiquitous

(Fisher et al., 2012)

embryonic stage 13 -- 16

organism | ubiquitous

(Fisher et al., 2012)

adult stage

(Gaines et al., 1999)

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Polypeptide Expression

mass spectroscopy

Stage

Tissue/Position (including subcellular localization)

Reference

adult stage

adult head

• membrane

(Aradska et al., 2015)

day 7 of adulthood -- day 49 of adulthood

adult heart

(Cammarato et al., 2011)

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Evidence

References

located_in cytosolic ribosome

inferred from direct assay

(Anger et al., 2013)

Expression Deduced from Reporters

High-Throughput Expression Data

Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\RpL37A in JBrowse

RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region

View exonic expression by developmental stage for Dmel\RpL37A

View exonic expression by tissue for Dmel\RpL37A

Bulk Downloads

RNA-Seq RPKM values for all genes

Reference

See Gelbart and Emmert, 2013 for analysis details and data files for all genes.

Developmental Proteome: Life Cycle

Developmental Proteome: Embryogenesis

External Data and Images

Linkouts

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0261608

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

44783/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0261608

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0028696

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0261608

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG5827

Images

FlyBase Wiki

Image Based Resources

Alleles, Insertions, Transgenic Constructs, and Aberrations

Classical and Insertion Alleles ( 4 )

For All Classical and Insertion Alleles Show

Other relevant insertions

Transgenic Constructs ( 5 )

For All Alleles Carried on Transgenic Constructs Show

Transgenic constructs containing/affecting coding region of RpL37A

Transgenic constructs containing regulatory region of RpL37A

Aberrations (Deficiencies and Duplications) ( 61 )

Inferred from experimentation ( 61 )

Gene disrupted in

Gene not disrupted in

Df(2L)2802

(Kotarski et al., 1983)

Df(2L)cl1

(Szidonya and Reuter, 1988, Szidonya and Reuter, 1988, Kotarski et al., 1983)

Df(2L)cl2

(Szidonya and Reuter, 1988, Szidonya and Reuter, 1988, Kotarski et al., 1983)

Df(2L)cl7

(Szidonya and Reuter, 1988, Szidonya and Reuter, 1988, Kotarski et al., 1983)

Df(2L)cl-h1

(Szidonya and Reuter, 1988, Szidonya and Reuter, 1988)

Df(2L)cl-h2

(Szidonya and Reuter, 1988, Szidonya and Reuter, 1988)

Df(2L)cl-h3

(Szidonya and Reuter, 1988, Szidonya and Reuter, 1988)

Df(2L)cl-h4

(Szidonya and Reuter, 1988, Szidonya and Reuter, 1988)

Df(2L)dp-h25

(Bryant et al., 1988)

Df(2L)dp-h28

(Bryant et al., 1988)

Df(2L)ed1

(Bryant et al., 1988, Reuter and Szidonya, 1983)

Df(2L)ed2

(Reuter and Szidonya, 1983)

Df(2L)Gpdh1-75

(Kotarski et al., 1983)

Df(2L)Gpdh1-78

(Kotarski et al., 1983)

Df(2L)Gpdh1-A

(Kotarski et al., 1983)

Df(2L)M24F11

(Bryant et al., 1988, Reuter and Szidonya, 1983)

Df(2L)M24F-B

(Bryant et al., 1988, Reuter and Szidonya, 1983)

Df(2L)sc19-3

(Bryant et al., 1988)

Df(2L)tkv2

(Szidonya and Reuter, 1988, Szidonya and Reuter, 1988, Reuter and Szidonya, 1983)

T(Y;2)P8

(Reuter and Szidonya, 1983)

Ts(YLt;2Lt)D6+Ts(YSt;2Rt)B137

(Kotarski et al., 1983)

Inferred from location ( 3 )

Variants

Variant Molecular Consequences

Alleles Representing Disease-Implicated Variants

Phenotypes

For more details about a specific phenotype click on the relevant allele symbol.

Lethality

Allele

lethal, with Scer\GAL4^pnr-MD237

RpL37A^GD13704

lethal | pupal stage, with Scer\GAL4^pnr-MD237

RpL37A^GD13704

lethal - all die during larval stage, with Scer\GAL4^Mef2.PR

RpL37A^GD13704

partially lethal, with Dcr-2^UAS.cDa, Scer\GAL4^elav.PLu

RpL37A^GD13704

partially lethal, with Scer\GAL4^tin.CΔ4

RpL37A^GD13704

Other Phenotypes

Allele

Minute | dominant

RpL37A¹

some die during larval stage, with Scer\GAL4^tin.CΔ4

RpL37A^GD13704

some die during pupal stage, with Dcr-2^UAS.cDa, Scer\GAL4^elav.PLu

RpL37A^GD13704

visible | dominant

RpL37A¹

Phenotype manifest in

Allele

larval somatic muscle cell, with Scer\GAL4^Mef2.PR

RpL37A^GD13704

macrochaeta

RpL37A¹

sarcomere, with Scer\GAL4^Mef2.PR

RpL37A^GD13704

Z disc, with Scer\GAL4^Mef2.PR

RpL37A^GD13704

Orthologs

Downloads

Download All DIOPT Orthologs

Human Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Homo sapiens (Human) (2)

Hsap\RPL37A

12 of 14

Yes

Hsap\RPL37AP8

6 of 14

Yes

Model Organism Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Rattus norvegicus (Norway rat) (7)

Rnor\Rpl37a

12 of 14

Yes

Rnor\LOC679823

9 of 14

Yes

Rnor\Rpl37a-ps1

9 of 14

Yes

Rnor\RGD1564849

8 of 14

Yes

Rnor\LOC689346

1 of 14

Yes

Rnor\LOC108348813

1 of 14

Yes

Rnor\RGD1559951

1 of 14

Yes

Mus musculus (laboratory mouse) (1)

Mmus\Rpl37a

11 of 14

Yes

Xenopus tropicalis (Western clawed frog) (2)

Xtro\rpl37a

10 of 13

Yes

Xtro\LOC100491346

2 of 13

Yes

Danio rerio (Zebrafish) (1)

Drer\zgc:171772

11 of 14

Yes

Caenorhabditis elegans (Nematode, roundworm) (1)

Cele\rpl-43

13 of 14

Yes

Anopheles gambiae (African malaria mosquito) (1)

Agam\AgaP_AGAP009920

11 of 12

Yes

Arabidopsis thaliana (thale-cress) (2)

Atha\AT3G10950

13 of 13

Yes

Atha\AT3G60245

11 of 13

Yes

Saccharomyces cerevisiae (Brewer's yeast) (2)

Scer\RPL43A

12 of 13

Yes

Scer\RPL43B

12 of 13

Yes

Schizosaccharomyces pombe (Fission yeast) (2)

Spom\rpl4301

11 of 12

Yes

Spom\rpl4302

11 of 12

Yes

Escherichia coli (enterobacterium) (0)

Other Organism Orthologs (via OrthoDB)

Data provided directly from OrthoDB:RpL37A. Refer to their site for version information.

Paralogs

Downloads

Download All DIOPT Paralogs

Paralogs (via DIOPT v9.1)

Gene Symbol

Score

Source

Alignment

Drosophila melanogaster (Fruit fly) (0)

Human Disease Associations

FlyBase Human Disease Model Reports

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Allele

Disease

Evidence

References

Potential Models Based on Orthology ( 0 )

Human Ortholog

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Allele

Disease

Interaction

References

Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)

Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.

Homo sapiens (Human)

Gene name

Score

OMIM

OMIM Phenotype

DO term

Complementation?

Transgene?

RPL37A; ribosomal protein L37a

12 of 14

613314

RPL37AP8; ribosomal protein L37a pseudogene 8

6 of 14

Functional Complementation Data

Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.

Interactions

Summary of Physical Interactions

esyN Network Diagram

Show neighbor-neighbor interactions:

Off

Show/hide secondary interactors
(data from AllianceMine provided by esyN)

Select Layout:

Force Directed

Circle

Concentric

Legend:

Protein

RNA

Selected Interactor(s)

Other Interaction Browsers

View in FlyBase Interactions Browser View in MIST tool (external link)

Please see the Physical Interaction reports below for full details

protein-protein

Physical Interaction

Assay

References

RpL37A - Rack1

cosedimentation, electron microscopy

(Anger et al., 2013)

RpL37A - RpL10

cosedimentation, Identification by mass spectrometry, electron microscopy

(Anger et al., 2013)

RpL37A - RpL10Ab

cosedimentation, Identification by mass spectrometry, electron microscopy

(Anger et al., 2013)

RpL37A - RpL11

cosedimentation, Identification by mass spectrometry, electron microscopy

(Anger et al., 2013)

RpL37A - RpL12

cosedimentation, Identification by mass spectrometry, electron microscopy

(Anger et al., 2013)

RpL37A - RpL13

cosedimentation, Identification by mass spectrometry, electron microscopy

(Anger et al., 2013)

RpL37A - RpL13A

cosedimentation, Identification by mass spectrometry, electron microscopy

(Anger et al., 2013)

RpL37A - RpL14

cosedimentation, Identification by mass spectrometry, electron microscopy

(Anger et al., 2013)

RpL37A - RpL15

cosedimentation, Identification by mass spectrometry, electron microscopy

(Anger et al., 2013)

RpL37A - RpL17

cosedimentation, Identification by mass spectrometry, electron microscopy

(Anger et al., 2013)

RpL37A - RpL18

cosedimentation, Identification by mass spectrometry, electron microscopy

(Anger et al., 2013)

RpL37A - RpL18A

cosedimentation, Identification by mass spectrometry, electron microscopy

(Anger et al., 2013)

RpL37A - RpL19

cosedimentation, Identification by mass spectrometry, electron microscopy

(Anger et al., 2013)

RpL37A - RpL21

cosedimentation, Identification by mass spectrometry, electron microscopy

(Anger et al., 2013)

RpL37A - RpL22

cosedimentation, Identification by mass spectrometry, electron microscopy

(Anger et al., 2013)

RpL37A - RpL23

cosedimentation, Identification by mass spectrometry, electron microscopy

(Anger et al., 2013)

RpL37A - RpL23A

cosedimentation, Identification by mass spectrometry, electron microscopy

(Anger et al., 2013)

RpL37A - RpL24

cosedimentation, Identification by mass spectrometry, electron microscopy

(Anger et al., 2013)

RpL37A - RpL26

cosedimentation, Identification by mass spectrometry, electron microscopy

(Anger et al., 2013)

RpL37A - RpL27

cosedimentation, Identification by mass spectrometry, electron microscopy

(Anger et al., 2013)

RpL37A - RpL27A

cosedimentation, Identification by mass spectrometry, electron microscopy

(Anger et al., 2013)

RpL37A - RpL28

cosedimentation, Identification by mass spectrometry, electron microscopy

(Anger et al., 2013)

RpL37A - RpL29

cosedimentation, Identification by mass spectrometry, electron microscopy

(Anger et al., 2013)

RpL37A - RpL3

cosedimentation, Identification by mass spectrometry, electron microscopy

(Anger et al., 2013)

RpL37A - RpL30

cosedimentation, Identification by mass spectrometry, electron microscopy

(Anger et al., 2013)

RpL37A - RpL31

cosedimentation, Identification by mass spectrometry, electron microscopy

(Anger et al., 2013)

RpL37A - RpL32

cosedimentation, Identification by mass spectrometry, electron microscopy

(Anger et al., 2013)

RpL37A - RpL34a

cosedimentation, Identification by mass spectrometry, electron microscopy

(Anger et al., 2013)

RpL37A - RpL35

cosedimentation, electron microscopy

(Anger et al., 2013)

RpL37A - RpL35A

cosedimentation, electron microscopy

(Anger et al., 2013)

RpL37A - RpL36

cosedimentation, Identification by mass spectrometry, electron microscopy

(Anger et al., 2013)

RpL37A - RpL36A

cosedimentation, Identification by mass spectrometry, electron microscopy

(Anger et al., 2013)

RpL37A - RpL37-1

cosedimentation, Identification by mass spectrometry, electron microscopy

(Anger et al., 2013)

RpL37A - RpL38

cosedimentation, Identification by mass spectrometry, electron microscopy

(Anger et al., 2013)

RpL37A - RpL39

cosedimentation, electron microscopy

(Anger et al., 2013)

RpL37A - RpL4

cosedimentation, Identification by mass spectrometry, electron microscopy

(Anger et al., 2013)

RpL37A - RpL40

cosedimentation, electron microscopy

(Anger et al., 2013)

RpL37A - RpL41

cosedimentation, electron microscopy

(Anger et al., 2013)

RpL37A - RpL5

cosedimentation, Identification by mass spectrometry, electron microscopy

(Anger et al., 2013)

RpL37A - RpL6

cosedimentation, Identification by mass spectrometry, electron microscopy

(Anger et al., 2013)

RpL37A - RpL7

cosedimentation, Identification by mass spectrometry, electron microscopy

(Anger et al., 2013)

RpL37A - RpL7A

cosedimentation, Identification by mass spectrometry, electron microscopy

(Anger et al., 2013)

RpL37A - RpL8

cosedimentation, Identification by mass spectrometry, electron microscopy

(Anger et al., 2013)

RpL37A - RpL9

cosedimentation, Identification by mass spectrometry, electron microscopy

(Anger et al., 2013)

RpL37A - RpLP0

cosedimentation, Identification by mass spectrometry, electron microscopy

(Anger et al., 2013)

RpL37A - RpLP1

cosedimentation, Identification by mass spectrometry, electron microscopy

(Anger et al., 2013)

RpL37A - RpLP2

cosedimentation, Identification by mass spectrometry, electron microscopy

(Anger et al., 2013)

RpL37A - RpS10a

cosedimentation, Identification by mass spectrometry, electron microscopy

(Anger et al., 2013)

RpL37A - RpS11

cosedimentation, Identification by mass spectrometry, electron microscopy

(Anger et al., 2013)

RpL37A - RpS12

cosedimentation, Identification by mass spectrometry, electron microscopy

(Anger et al., 2013)

RpL37A - RpS13

cosedimentation, Identification by mass spectrometry, electron microscopy

(Anger et al., 2013)

RpL37A - RpS14a

cosedimentation, Identification by mass spectrometry, electron microscopy

(Anger et al., 2013)

RpL37A - RpS14b

cosedimentation, Identification by mass spectrometry, electron microscopy

(Anger et al., 2013)

RpL37A - RpS15

cosedimentation, Identification by mass spectrometry, electron microscopy

(Anger et al., 2013)

RpL37A - RpS15Aa

cosedimentation, Identification by mass spectrometry, electron microscopy

(Anger et al., 2013)

RpL37A - RpS16

cosedimentation, Identification by mass spectrometry, electron microscopy

(Anger et al., 2013)

RpL37A - RpS17

cosedimentation, Identification by mass spectrometry, electron microscopy

(Anger et al., 2013)

RpL37A - RpS18

cosedimentation, Identification by mass spectrometry, electron microscopy

(Anger et al., 2013)

RpL37A - RpS19a

cosedimentation, Identification by mass spectrometry, electron microscopy

(Anger et al., 2013)

RpL37A - RpS2

cosedimentation, Identification by mass spectrometry, electron microscopy

(Anger et al., 2013)

RpL37A - RpS20

cosedimentation, Identification by mass spectrometry, electron microscopy

(Anger et al., 2013)

RpL37A - RpS21

cosedimentation, Identification by mass spectrometry, electron microscopy

(Anger et al., 2013)

RpL37A - RpS23

cosedimentation, Identification by mass spectrometry, electron microscopy

(Anger et al., 2013)

RpL37A - RpS24

cosedimentation, Identification by mass spectrometry, electron microscopy

(Anger et al., 2013)

RpL37A - RpS25

cosedimentation, Identification by mass spectrometry, electron microscopy

(Anger et al., 2013)

RpL37A - RpS26

cosedimentation, Identification by mass spectrometry, electron microscopy

(Anger et al., 2013)

RpL37A - RpS27

cosedimentation, Identification by mass spectrometry, electron microscopy

(Anger et al., 2013)

RpL37A - RpS27A

cosedimentation, Identification by mass spectrometry, electron microscopy

(Anger et al., 2013)

RpL37A - RpS28b

cosedimentation, Identification by mass spectrometry, electron microscopy

(Anger et al., 2013)

RpL37A - RpS29

cosedimentation, Identification by mass spectrometry, electron microscopy

(Anger et al., 2013)

RpL37A - RpS3

cosedimentation, Identification by mass spectrometry, electron microscopy

(Anger et al., 2013)

RpL37A - RpS30

cosedimentation, electron microscopy

(Anger et al., 2013)

RpL37A - RpS3A

cosedimentation, Identification by mass spectrometry, electron microscopy

(Anger et al., 2013)

RpL37A - RpS4

cosedimentation, Identification by mass spectrometry, electron microscopy

(Anger et al., 2013)

RpL37A - RpS5a

cosedimentation, Identification by mass spectrometry, electron microscopy

(Anger et al., 2013)

RpL37A - RpS6

cosedimentation, Identification by mass spectrometry, electron microscopy

(Anger et al., 2013)

RpL37A - RpS7

cosedimentation, Identification by mass spectrometry, electron microscopy

(Anger et al., 2013)

RpL37A - RpS8

cosedimentation, Identification by mass spectrometry, electron microscopy

(Anger et al., 2013)

RpL37A - RpS9

cosedimentation, Identification by mass spectrometry, electron microscopy

(Anger et al., 2013)

RpL37A - cnk

anti tag coimmunoprecipitation, peptide massfingerprinting

(Friedman et al., 2011)

RpL37A - csw

anti tag coimmunoprecipitation, peptide massfingerprinting

(Friedman et al., 2011)

RpL37A - eEF2

cosedimentation, Identification by mass spectrometry, electron microscopy

(Anger et al., 2013)

RpL37A - sta

cosedimentation, Identification by mass spectrometry, electron microscopy

(Anger et al., 2013)

RpL37A - vig2

cosedimentation, Identification by mass spectrometry, electron microscopy

(Anger et al., 2013)

RNA-protein

Physical Interaction

Assay

References

RpL37A - 18SrRNA

cosedimentation, electron microscopy

(Anger et al., 2013)

RpL37A - 28SrRNA

cosedimentation, electron microscopy

(Anger et al., 2013)

RpL37A - 2SrRNA

cosedimentation, electron microscopy

(Anger et al., 2013)

RpL37A - 5.8SrRNA

cosedimentation, electron microscopy

(Anger et al., 2013)

RpL37A - 5SrRNA

cosedimentation, electron microscopy

(Anger et al., 2013)

Summary of Genetic Interactions

esyN Network Diagram

Other Interaction Browsers

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

External Data

Linkouts

DroID - A comprehensive database of gene and protein interactions.

FBgn0261608

MIST (protein-protein) - An integrated Molecular Interaction Database

44783

Pathways

Signaling Pathways (FlyBase)

Metabolic Pathways

FlyBase

External Links

External Data

Linkouts

KEGG Pathways - A collection of manually drawn pathway maps representing knowledge of molecular interaction, reaction and relation networks.

Ribosome

Class of Gene

gene

nuclear_gene

protein_coding_gene

Genomic Location and Detailed Mapping Data

Chromosome (arm)

Recombination map

2-15

Cytogenetic map

25C4-25C4

Sequence location

2L:5,070,957..5,072,055 [+]

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

25C4-25C4

Limits computationally determined from genome sequence between P{lacW}vkg^k16721&P{lacW}Cg25C^k00405 and P{lacW}l(2)k11206^k11206

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

25C1-25C3

(determined by in situ hybridisation)

(Gaines et al., 1999)

Experimentally Determined Recombination Data

Location

2-15

(FlyBase, 2016)

2-16.5

(Comeron et al., 2012)

2-15.0

(Reuter and Szidonya, 1983)

2-15.03

(Curry, 1939)

Left of (cM)

(Curry, 1939)

Right of (cM)

(Curry, 1939)

Notes

Probably maps to the right of tkv.

(Curry, 1939)

Stocks and Reagents

Stocks (5)

Aberrations including deletions of this gene Aberrations including duplications of this gene

Bloomington

85969

w¹¹¹⁸; PBac{PB}RpL37A^c04777

FlyORF

F001766

M{UAS-RpL37A.ORF.3xHA}ZH-86Fb

NIG-Fly

2LG-1799

y² VhaAC39-1^cho-1 v¹; P{U6-RpL37A.NIG.sgRNA}attP40/CyO

VDRC

v107295

P{KK107718}VIE-260B

v23590

w¹¹¹⁸; P{GD13704}v23590

Genomic Clones (14)

Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

cDNA Clones (277)

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequenced

BDGP DGC clones

Other clones

Drosophila Genomics Resource Center cDNA clones

For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

FBgn0261608

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

Other clones

RNAi and Array Information

Linkouts

DRSC - Results frm RNAi screens

FBgn0261608

Antibody Information

Laboratory Generated Antibodies

Commercially Available Antibodies

Cell Line Information

Publicly Available Cell Lines

Other Stable Cell Lines

Other Comments

Haploinsufficient locus.

(Cook et al., 2012)

RNAi screen using dsRNA made from templates generated with primers directed against this gene results in aberrantly short, monopolar spindles when assayed in S2 cells. This phenotype can be observed when the screen is performed with or without Cdc27 dsRNA.

(Goshima et al., 2007)

Minute gene.

(Marygold et al., 2007)

Deletions removing RpL37A but no other cytoplasmic ribosomal protein-encoding genes show Minute phenotypes. The interval between flanking non-Minute deletions contains only RpL37A.

(Marygold et al., 2007)

"2-15.03" was stated as revision.

(Curry, 1939)

One of a class of genes (see MIN record) that when present in one, rather than two, copies, produce a characteristic phenotype consisting of short slender bristles and delayed development.

Relationship to Other Genes

Source for database merge of

Source for merge of: RpL37a CG5827

(Bayraktaroglu, 2000.11.2)

Source for merge of: RpL37A M(2)25C

(Marygold et al., 2007)

Source for merge of: RpL37a BcDNA:RH41593

(FlyBase, 1996-)

Source for merge of: RpL37a BcDNA:RE23595

(FlyBase, 1996-)

Additional comments

"RpL37a" maps very near to "M(2)25C".

(Gaines et al., 1999)

Source for merge of RpL37a BcDNA:RH41593 was TrEMBL update ( date:020807 ).

(FlyBase, 1996-)

Source for merge of RpL37a BcDNA:RE23595 was TrEMBL update ( date:020807 ).

(FlyBase, 1996-)

Nomenclature History

Source for database identify of

Nomenclature comments

Etymology

Synonyms and Secondary IDs (15)

Reported As

Symbol Synonym

BcDNA:RE23595

BcDNA:RH41593

CG5827

(National Institute of Genetics Fly Stocks, 2022-, Kolkhof et al., 2017, Fukuoh et al., 2014, Schertel et al., 2013, Cammarato et al., 2011, Keleman et al., 2009.8.5, Goshima et al., 2007, Marygold et al., 2007, Wang et al., 2004)

DmL37a

(Gaines et al., 1999)

L37A

(Ramond et al., 2020, Molnar et al., 2003)

L43e

(Anger et al., 2013)

M(2)25C

(Marygold et al., 2007)

M(2)S1

(Bryant et al., 1988, Szidonya and Reuter, 1988, Szidonya and Reuter, 1988, Kotarski et al., 1983, Reuter and Szidonya, 1983, Lindsley et al., 1972, Seattle-La Jolla Drosophila Laboratories, 1971, Curry, 1939)

RpL37A

(Ding et al., 2022, Loganathan et al., 2022, Rounds et al., 2022, Baumgartner et al., 2021, Polymenis, 2020, Housden et al., 2017, Joshi and Meller, 2017, Wei et al., 2015, Bischof and FlyORF project members, 2014.6.20, Handler et al., 2013, Kwon et al., 2013, Schertel et al., 2013, Cook et al., 2012, Tran et al., 2012, Friedman et al., 2011, Goshima et al., 2007, Marygold et al., 2007)

RpL37a

(Gaines et al., 2000)

chr2L:5071724..5071820

(Will et al., 2013)

l(2)25Cb

Name Synonyms

Minute (2) 25C

Ribosomal protein L37A

(Cammarato et al., 2011, Ashburner and Marygold, 2004.7.2)

Ribosomal protein L37a

(Gaines et al., 1999)

Secondary FlyBase IDs

FBgn0005510
FBgn0001921
FBgn0002596
FBgn0028696
FBgn0031680
FBgn0047015
FBgn0047145

Datasets (0)

Study focus (0)

Experimental Role

Project

Project Type

Title

Study result (0)

Result

Result Type

Title

External Crossreferences and Linkouts ( 44 )

Sequence Crossreferences

NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.

44783

GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.

GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.

RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.

UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.

Q9VMU4

UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information

Q9VMU4

UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information

M9MRF2

Other crossreferences

AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.

Q9VMU4

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0261608

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

44783/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0261608

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0261608

InterPro - A database of protein families, domains and functional sites

KEGG Genes - Molecular building blocks of life in the genomic space.

dme:Dmel_CG5827

MARRVEL_MODEL - MARRVEL (model organism gene)

44783

PDB - An information portal to biological macromolecular structures

Linkouts

Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones

FBgn0261608

DroID - A comprehensive database of gene and protein interactions.

FBgn0261608

DRSC - Results frm RNAi screens

FBgn0261608

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0028696

FlyCyc Genes - Genes from a BioCyc PGDB for Dmel

FBGN0261608

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG5827

iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)

TC006567

KEGG Pathways - A collection of manually drawn pathway maps representing knowledge of molecular interaction, reaction and relation networks.

Ribosome

MIST (protein-protein) - An integrated Molecular Interaction Database

44783

References (72)

The following external sites may use different assemblies or annotations than FlyBase.

-1.32

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