FB2025_05 , released December 11, 2025
Gene: Dmel\CngA
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General Information
Symbol
Dmel\CngA
Species
D. melanogaster
Name
Cyclic nucleotide-gated ion channel subunit A
Annotation Symbol
CG42701
Feature Type
protein_coding_gene
FlyBase ID
FBgn0261612
Gene Model Status
Current
Stock Availability
11 publicly available
Gene Summary
Cyclic nucleotide-gated ion channel subunit A (CngA) encodes a non-selective cation channel related to the superfamily of voltage-gated ion channels. It is involved in both excitation and adaptation of sensory cells, as well as in Ca[2+] response in the mushroom bodies. [Date last reviewed: 2019-02-28] (FlyBase Gene Snapshot)
All Summaries
Also Known As

Cng, DmCNGC, Cyclic-nucleotide-gated ion channel protein

Key Links
Genomic Location
Cytogenetic map
53A1-53A2
Sequence location
Recombination map
2-79
RefSeq locus
NT_033778 REGION:16243145..16259805
Sequence
Get Decorated FASTA
Genomic Maps
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
NCBI
UCSC
Ensembl
PopFly
Function
Gene Ontology (GO) Annotations (13 terms)
Molecular Function (5 terms)
Terms Based on Experimental Evidence (1 term)
CV Term
Evidence
References
enables intracellularly cyclic nucleotide-activated monoatomic cation channel activity
inferred from direct assay
(Dzeja et al., 1999, Finn et al., 1998, Baumann et al., 1994)
Terms Based on Predictions or Assertions (5 terms)
CV Term
Evidence
References
enables cGMP binding
inferred from biological aspect of ancestor with PANTHER:PTN000025806
(GO Reference Genome Project, 2011-)
enables intracellularly cAMP-activated cation channel activity
inferred from biological aspect of ancestor with PANTHER:PTN000025806
(GO Reference Genome Project, 2011-)
enables intracellularly cGMP-activated cation channel activity
inferred from biological aspect of ancestor with PANTHER:PTN000811708
(GO Reference Genome Project, 2011-)
enables intracellularly cyclic nucleotide-activated monoatomic cation channel activity
inferred from electronic annotation with InterPro:IPR050866
(InterPro Project Members, 2004-)
enables monoatomic ion channel activity
inferred from electronic annotation with InterPro:IPR005821
(InterPro Project Members, 2004-)
Biological Process (5 terms)
Terms Based on Experimental Evidence (2 terms)
CV Term
Evidence
References
involved_in monoatomic cation transmembrane transport
inferred from direct assay
(Dzeja et al., 1999, Finn et al., 1998, Baumann et al., 1994)
involved_in response to hypoxia
inferred from mutant phenotype
(Vermehren-Schmaedick et al., 2010)
inferred from genetic interaction with FLYBASE:Gyc89Da; FB:FBgn0038435,FLYBASE:Gyc89Db; FB:FBgn0038436
(Vermehren-Schmaedick et al., 2010)
Terms Based on Predictions or Assertions (4 terms)
CV Term
Evidence
References
involved_in monoatomic cation transmembrane transport
inferred from biological aspect of ancestor with PANTHER:PTN000811708
(GO Reference Genome Project, 2011-)
involved_in monoatomic ion transport
inferred from electronic annotation with InterPro:IPR005821
(InterPro Project Members, 2004-)
involved_in sensory perception of chemical stimulus
inferred from biological aspect of ancestor with PANTHER:PTN000025806
(GO Reference Genome Project, 2011-)
involved_in transmembrane transport
inferred from electronic annotation with InterPro:IPR005821
(InterPro Project Members, 2004-)
Cellular Component (3 terms)
Terms Based on Experimental Evidence (1 term)
CV Term
Evidence
References
part_of intracellular cyclic nucleotide activated cation channel complex
inferred from direct assay
(Dzeja et al., 1999, Finn et al., 1998, Baumann et al., 1994)
Terms Based on Predictions or Assertions (3 terms)
CV Term
Evidence
References
part_of intracellular cyclic nucleotide activated cation channel complex
inferred from biological aspect of ancestor with PANTHER:PTN000811708
(GO Reference Genome Project, 2011-)
non-traceable author statement
(MacPherson et al., 2001)
located_in membrane
inferred from electronic annotation with InterPro:IPR005821
(InterPro Project Members, 2004-)
is_active_in plasma membrane
inferred from biological aspect of ancestor with PANTHER:PTN000811708
(GO Reference Genome Project, 2011-)
Gene Group (FlyBase)
Protein Family (UniProt)
Belongs to the cyclic nucleotide-gated cation channel (TC 1.A.1.5) family. (Q24278)
Protein Signatures (InterPro)
Summaries
Gene Snapshot
Cyclic nucleotide-gated ion channel subunit A (CngA) encodes a non-selective cation channel related to the superfamily of voltage-gated ion channels. It is involved in both excitation and adaptation of sensory cells, as well as in Ca[2+] response in the mushroom bodies. [Date last reviewed: 2019-02-28]
Gene Group (FlyBase)
CYCLIC NUCLEOTIDE-GATED CHANNEL SUBUNITS -
Cyclic-nucleotide-gated channels (CNG) are non-selective cation channels activated by intracellular cAMP or cGMP. (Adapted from FBrf0149151 and FBrf0102034.)
Protein Function (UniProtKB)
Approximately 50-fold more sensitive to cGMP than to cAMP. May be involved in transduction cascades of both invertebrate photoreceptors and olfactory sensillae.
(UniProt, Q24278)
Gene Model and Products
Number of Transcripts
2
Number of Unique Polypeptides
2

Please see the JBrowse view of Dmel\CngA for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Structure
Protein 3D structure   (Predicted by AlphaFold)   (AlphaFold entry Q24278)

If you don't see a structure in the viewer, refresh your browser.
Model Confidence:
  • Very high (pLDDT > 90)
  • Confident (90 > pLDDT > 70)
  • Low (70 > pLDDT > 50)
  • Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Experimentally Determined Structures
Crossreferences
Comments on Gene Model

Gene model reviewed during 5.50

Gene model reviewed during 5.55

Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
CngA-RA
FBtr0302924
NM_057768
2975
665
CngA-RB
FBtr0302925
NM_001202031
3994
840
Additional Transcript Data and Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
UniProt
RefSeq ID
GenBank
CngA-PA
FBpp0292050
75.8
665
9.32
Q24278
NP_477116
AAF58033
CngA-PB
FBpp0292051
95.3
840
7.38
A0A0B4JCU4
NP_001188960
ADV37206
Polypeptides with Identical Sequences

None of the polypeptides share 100% sequence identity.

Additional Polypeptide Data and Comments
Reported size (kDa)
Comments
External Data
Crossreferences
InterPro - A database of protein families, domains and functional sites
Linkouts
Sequences Consistent with the Gene Model
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\CngA using the Feature Mapper tool.

External Data
Crossreferences
Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
Linkouts
Expression Data
Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

0.19

Transcript Expression
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Polypeptide Expression
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Evidence
References
part_of intracellular cyclic nucleotide activated cation channel complex
inferred from direct assay
(Dzeja et al., 1999, Finn et al., 1998, Baumann et al., 1994)
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\CngA in JBrowse
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Bulk Downloads
RNA-Seq RPKM values for all genes
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
Flygut - An atlas of the Drosophila adult midgut
Images
FlyBase Wiki
Image Based Resources
Alleles, Insertions, Transgenic Constructs, and Aberrations
Classical and Insertion Alleles ( 6 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 7 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of CngA
Transgenic constructs containing regulatory region of CngA
Aberrations (Deficiencies and Duplications) ( 1 )
Inferred from experimentation ( 1 )
Gene disrupted in
Df(2R)Exel6063
(Ryder, 2004.4.26)
Inferred from location ( 7 )
Variants
Variant Molecular Consequences
Alleles Representing Disease-Implicated Variants
Phenotypes
Orthologs
Downloads
Download All DIOPT Orthologs
Human Orthologs (via DIOPT v9.1)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
Domainoid
eggNOG
Hieranoid
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Complementation?
Transgene?
Homo sapiens (Human) (21)
Hsap\CNGA1
13 of 14
Yes
Yes
Hsap\CNGA2
13 of 14
Yes
Yes
Hsap\CNGA3
13 of 14
Yes
Yes
1  
Hsap\CNGA4
10 of 14
No
Yes
Hsap\CNGB1
4 of 14
No
No
Hsap\CNGB3
4 of 14
No
No
Hsap\HCN1
2 of 14
No
No
Hsap\HCN2
2 of 14
No
No
2  
Hsap\HCN3
2 of 14
No
No
Hsap\HCN4
2 of 14
No
No
Hsap\KCNH2
2 of 14
No
No
Hsap\KCNH3
2 of 14
No
No
Hsap\KCNH4
2 of 14
No
No
Hsap\KCNH6
2 of 14
No
No
Hsap\KCNH7
2 of 14
No
No
1  
Hsap\KCNH8
2 of 14
No
No
1  
Hsap\KCNH1
1 of 14
No
No
Hsap\KCNH5
1 of 14
No
No
Hsap\PRKAR1A
1 of 14
No
No
1  
Hsap\PRKAR1B
1 of 14
No
No
1  
Hsap\PRKG2
1 of 14
No
No
1  
Model Organism Orthologs (via DIOPT v9.1)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
Domainoid
eggNOG
Hieranoid
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Complementation?
Transgene?
Rattus norvegicus (Norway rat) (18)
Rnor\Cnga1
13 of 14
Yes
Yes
Rnor\Cnga3
13 of 14
Yes
Yes
Rnor\Cnga2
11 of 14
No
Yes
Rnor\Cnga4
10 of 14
No
Yes
Rnor\Cngb1
4 of 14
No
No
Rnor\Cngb3
4 of 14
No
No
Rnor\Hcn1
2 of 14
No
No
Rnor\Hcn2
2 of 14
No
No
Rnor\Hcn3
2 of 14
No
No
Rnor\Hcn4
2 of 14
No
No
Rnor\Kcnh2
2 of 14
No
No
Rnor\Kcnh3
2 of 14
No
No
Rnor\Kcnh4
2 of 14
No
No
Rnor\Kcnh6
2 of 14
No
No
Rnor\Kcnh7
2 of 14
No
No
Rnor\Kcnh8
2 of 14
No
No
Rnor\Kcnh1
1 of 14
No
No
Rnor\Kcnh5
1 of 14
No
No
Mus musculus (laboratory mouse) (18)
Mmus\Cnga1
13 of 14
Yes
Yes
Mmus\Cnga3
13 of 14
Yes
Yes
Mmus\Cnga2
12 of 14
No
Yes
Mmus\Cnga4
10 of 14
No
Yes
Mmus\Cngb1
4 of 14
No
No
Mmus\Cngb3
4 of 14
No
No
Mmus\Hcn1
2 of 14
No
No
Mmus\Hcn2
2 of 14
No
No
Mmus\Hcn3
2 of 14
No
No
Mmus\Hcn4
2 of 14
No
No
Mmus\Kcnh2
2 of 14
No
No
Mmus\Kcnh3
2 of 14
No
No
Mmus\Kcnh4
2 of 14
No
No
Mmus\Kcnh6
2 of 14
No
No
Mmus\Kcnh7
2 of 14
No
No
Mmus\Kcnh8
2 of 14
No
No
Mmus\Kcnh1
1 of 14
No
No
Mmus\Kcnh5
1 of 14
No
No
Xenopus tropicalis (Western clawed frog) (24)
Xtro\cnga3
11 of 13
Yes
Yes
Xtro\cnga2
10 of 13
No
Yes
Xtro\cnga1
8 of 13
No
Yes
Xtro\cnga4
6 of 13
No
Yes
Xtro\cngb3
3 of 13
No
No
Xtro\cngb1
2 of 13
No
No
Xtro\epm2a
1 of 13
No
No
Xtro\fermt3
1 of 13
No
No
Xtro\hcn1
1 of 13
No
No
Xtro\hcn4
1 of 13
No
No
Xtro\kcnh1
1 of 13
No
No
Xtro\kcnh3
1 of 13
No
No
Xtro\kcnh4
1 of 13
No
No
Xtro\kcnh7
1 of 13
No
No
Xtro\kcnh8
1 of 13
No
No
Xtro\LOC100492237
1 of 13
No
No
Xtro\prkg1
1 of 13
No
No
Xtro\rhbdf1
1 of 13
No
No
Xtro\slc26a11
1 of 13
No
No
Xtro\slc38a7
1 of 13
No
No
Xtro\tcte1
1 of 13
No
No
Xtro\wnt8b
1 of 13
No
No
Xtro\XB972976
1 of 13
No
No
Xtro\yy1
1 of 13
No
No
Danio rerio (Zebrafish) (29)
Drer\cnga3a
14 of 14
Yes
Yes
Drer\cnga1a
13 of 14
No
Yes
Drer\cnga1b
13 of 14
No
Yes
Drer\cnga2a
12 of 14
No
Yes
Drer\LOC100334711
11 of 14
No
Yes
Drer\cnga2b
10 of 14
No
Yes
Drer\cnga4
9 of 14
No
Yes
Drer\cngb1a
4 of 14
No
No
Drer\cngb3.1
4 of 14
No
No
Drer\LOC562466
4 of 14
No
No
Drer\hcn2b
2 of 14
No
No
Drer\hcn3
2 of 14
No
No
Drer\hcn4
2 of 14
No
No
Drer\hcn4l
2 of 14
No
No
Drer\kcnh2a
2 of 14
No
No
Drer\kcnh4a
2 of 14
No
No
Drer\kcnh4b
2 of 14
No
No
Drer\kcnh6a
2 of 14
No
No
Drer\kcnh7
2 of 14
No
No
Drer\kcnh8
2 of 14
No
No
Drer\LOC100334297
2 of 14
No
No
Drer\cngk
1 of 14
No
No
Drer\hcn5
1 of 14
No
No
Drer\kcnh1a
1 of 14
No
No
Drer\kcnh1b
1 of 14
No
No
Drer\kcnh3
1 of 14
No
No
Drer\kcnh5a
1 of 14
No
No
Drer\kcnh5b
1 of 14
No
No
Drer\kcnh6b
1 of 14
No
No
Caenorhabditis elegans (Nematode, roundworm) (8)
Cele\tax-4
14 of 14
Yes
Yes
Cele\che-6
6 of 14
No
Yes
Cele\cng-3
6 of 14
No
Yes
Cele\cng-1
4 of 14
No
Yes
Cele\cng-2
4 of 14
No
Yes
Cele\tax-2
3 of 14
No
No
Cele\egl-2
1 of 14
No
No
Cele\unc-103
1 of 14
No
No
Anopheles gambiae (African malaria mosquito) (12)
Agam\AgaP_AGAP009050
12 of 12
Yes
Yes
Agam\AgaP_AGAP007008
4 of 12
No
No
Agam\AgaP_AGAP003349
3 of 12
No
No
Agam\AgaP_AGAP011459
3 of 12
No
No
Agam\AgaP_AGAP002150
2 of 12
No
No
Agam\AgaP_AGAP002719
1 of 12
No
No
Agam\AgaP_AGAP005251
1 of 12
No
No
Agam\AgaP_AGAP005463
1 of 12
No
No
Agam\AgaP_AGAP007709
1 of 12
No
No
Agam\AgaP_AGAP007800
1 of 12
No
No
Agam\AgaP_AGAP008976
1 of 12
No
No
Agam\AgaP_AGAP010000
1 of 12
No
No
Arabidopsis thaliana (thale-cress) (29)
Atha\KAT3
4 of 13
Yes
No
Atha\CNGC13
3 of 13
No
Yes
Atha\CNGC14
3 of 13
No
Yes
Atha\CNGC15
3 of 13
No
Yes
Atha\CNGC17
3 of 13
No
Yes
Atha\CNGC18
3 of 13
No
Yes
Atha\DND1
3 of 13
No
Yes
Atha\GORK
3 of 13
No
No
Atha\KT5
3 of 13
No
No
Atha\SKOR
3 of 13
No
No
Atha\SPIK
3 of 13
No
No
Atha\CNGC1
2 of 13
No
No
Atha\CNGC3
2 of 13
No
No
Atha\CNGC4
2 of 13
No
No
Atha\CNGC5
2 of 13
No
No
Atha\CNGC6
2 of 13
No
No
Atha\CNGC7
2 of 13
No
No
Atha\CNGC8
2 of 13
No
No
Atha\CNGC9
2 of 13
No
No
Atha\CNGC10
2 of 13
No
No
Atha\CNGC11
2 of 13
No
No
Atha\CNGC12
2 of 13
No
No
Atha\CNGC16
2 of 13
No
No
Atha\KAT1
2 of 13
No
No
Atha\KAT2
2 of 13
No
No
Atha\KT1
2 of 13
No
No
Atha\KT2/3
2 of 13
No
No
Atha\CNBT1
1 of 13
No
No
Atha\CNGC19
1 of 13
No
No
Saccharomyces cerevisiae (Brewer's yeast) (0)
Schizosaccharomyces pombe (Fission yeast) (0)
Escherichia coli (enterobacterium) (0)
Other Organism Orthologs (via OrthoDB)
Data provided directly from OrthoDB:CngA. Refer to their site for version information.
Paralogs
Downloads
Download All DIOPT Paralogs
Paralogs (via DIOPT v9.1)
Gene Symbol
Score
Source
Compara
Domainoid
eggNOG
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Drosophila melanogaster (Fruit fly) (9)
CG42260
8 of 13
Cngl
8 of 13
CngB
6 of 13
Ih
5 of 13
eag
3 of 13
Elk
3 of 13
sei
3 of 13
CG6026
1 of 13
for
1 of 13
Human Disease Associations
FlyBase Human Disease Model Reports
    Disease Ontology (DO) Annotations
    Models Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Evidence
    References
    Potential Models Based on Orthology ( 2 )
    Modifiers Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Interaction
    References
    Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)
    Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
    Homo sapiens (Human)
    Gene name
    Score
    OMIM
    OMIM Phenotype
    DO term
    Complementation?
    Transgene?
    CNGA1; cyclic nucleotide gated channel subunit alpha 1
    13 of 14
    123825
    CNGA2; cyclic nucleotide gated channel subunit alpha 2
    13 of 14
    300338
        CNGA3; cyclic nucleotide gated channel subunit alpha 3
        13 of 14
        600053
         
        CNGA4; cyclic nucleotide gated channel subunit alpha 4
        10 of 14
        609472
            CNGB1; cyclic nucleotide gated channel subunit beta 1
            4 of 14
            600724
            CNGB3; cyclic nucleotide gated channel subunit beta 3
            4 of 14
            605080
            Functional Complementation Data
            Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
            Interactions
            Summary of Physical Interactions
            Interaction Browsers
            Summary of Genetic Interactions
            Interaction Browsers
            Starting gene(s)
            Interaction type
            Interacting gene(s)
            Reference
            Starting gene(s)
            Interaction type
            Interacting gene(s)
            Reference
            External Data
            Linkouts
            DroID - A comprehensive database of gene and protein interactions.
            Pathways
            Signaling Pathways (FlyBase)
            Metabolic Pathways
            FlyBase
            External Links
            External Data
            Class of Gene
            Genomic Location and Detailed Mapping Data
            Chromosome (arm)
            2R
            Recombination map
            2-79
            Cytogenetic map
            53A1-53A2
            Sequence location
            FlyBase Computed Cytological Location
            Cytogenetic map
            Evidence for location
            53A1-53A2
            Limits computationally determined from genome sequence between P{lacW}Lis-1k11702&P{EP}CG8443EP969 and P{lacW}l(2)k07824k07824&P{lacW}vegk03402
            Experimentally Determined Cytological Location
            Cytogenetic map
            Notes
            References
            Experimentally Determined Recombination Data
            Location

            2-79

            (FlyBase, 2016)

            2-81.9

            (Comeron et al., 2012)
            Left of (cM)
            Right of (cM)
            Notes
            Stocks and Reagents
            Stocks (11)
            Genomic Clones (22)
            cDNA Clones (6)
             

            Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

            cDNA clones, fully sequenced
            BDGP DGC clones
              Other clones
                Drosophila Genomics Resource Center cDNA clones

                For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

                  cDNA Clones, End Sequenced (ESTs)
                  BDGP DGC clones
                    Other clones
                      RNAi and Array Information
                      Linkouts
                      DRSC - Results frm RNAi screens
                      Antibody Information
                      Laboratory Generated Antibodies
                       
                      Commercially Available Antibodies
                       
                      Cell Line Information
                      Publicly Available Cell Lines
                       
                        Other Stable Cell Lines
                         
                          Other Comments

                          The use of a reporter gene fusion to study the topology of proteins in a membrane has been used to determine the topology of the Cng channel.

                          (Henn et al., 1995)

                          The Cng channel gene has been cloned and is expressed in the visual and olfactory system. The electrical properties of the cloned cyclic nucleotide gated (CNG) channel resemble those of light activated channels in photoreceptors. The channel is highly permeable to calcium ions suggesting that it mediates a light induced calcium ions entry into cells. These results support the notion that CNG channels are involved in the transduction of light and chemical stimuli in invertebrates.

                          (Baumann et al., 1994)
                          Relationship to Other Genes
                          Source for database merge of

                          Source for merge of: Cng CG15709

                          (FlyBase Genome Annotators, 2010)
                          Additional comments

                          Annotations CG7779 and CG15709 merged as CG42701 in release 5.26 of the genome annotation.

                          (FlyBase Genome Annotators, 2010)
                          Nomenclature History
                          Source for database identify of

                          Source for identity of: CngA Cng

                          (FlyBase, 2009-)
                          Nomenclature comments

                          Renamed from 'Cng' to 'CngA' to: i) better distinguish from the 'CngB' gene; ii) reflect the clear orthology to the mammalian CNGA genes; iii) reflect the nomenclature used in FBrf0102034 and FBrf0149151.

                          (FlyBase, 2009-)
                          Etymology
                          Synonyms and Secondary IDs (16)
                          Datasets (0)
                          Study focus (0)
                          Experimental Role
                          Project
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                          Title
                          Study result (0)
                          Result
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                          External Crossreferences and Linkouts ( 45 )
                          Sequence Crossreferences
                          NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
                          GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
                          GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
                          RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
                          UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.
                          UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information
                          UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information
                          Other crossreferences
                          AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.
                          DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
                          EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
                          FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
                          InterPro - A database of protein families, domains and functional sites
                          KEGG Genes - Molecular building blocks of life in the genomic space.
                          MARRVEL_MODEL - MARRVEL (model organism gene)
                          Linkouts
                          DroID - A comprehensive database of gene and protein interactions.
                          DRSC - Results frm RNAi screens
                          Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
                          FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
                          FlyCyc Genes - Genes from a BioCyc PGDB for Dmel
                          Flygut - An atlas of the Drosophila adult midgut
                          FlyMet - A comprehensive tissue-specific metabolomics resource for Drosophila.
                          iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)
                          Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
                          References (64)