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Gene Dmel\mbl

General Information
Symbol	Dmel\mbl	Species	D. melanogaster
Name	muscleblind	Annotation symbol	CG33197
Feature type	protein_coding_gene	FlyBase ID	FBgn0261642
Gene Model Status	Current	Stock availability	27 publicly available
Also Known As	mm, cht, l(2)01038, l(2)k01212
Genomic Location
Chromosome (arm)	2R	Recombination map	2-
Cytogenetic map	54B1-54B5	Sequence location	2R:13,104,005..13,266,470 [+]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents modENCODE GBrowse	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene muscleblind is referred to in FlyBase by the symbol Dmel\mbl (CG33197, FBgn0261642). It is a protein_coding_gene from Drosophila melanogaster. It is reported to have molecular function: DNA binding; nucleic acid binding. There is experimental evidence that it is involved in the biological process: apoptotic process; compound eye photoreceptor cell differentiation; muscle organ development; embryo development; regulation of female receptivity. 67 alleles are reported. The phenotypes of these alleles are annotated with: organ system subdivision; external compound sense organ; adult segment; organ system; cytoplasmic part; peripheral nervous system; sarcomere; thoracic segment; organelle; histaminergic neuron. It has 15 annotated transcripts and 15 annotated polypeptides. Protein features are: Zinc finger, CCCH-type. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderate expression to a trough of very low expression. Peak expression observed within 12-24 hour embryonic stages, at stages throughout the pupal period. Summary of FlyAtlas Anatomical Expression Data: Two or more Affy2 ProbeSets identify exons of this gene. This is a summary of the tissue expression peaks exhibited in at least one of these ProbeSets. Expression in all larval and adult organs/tissues ranges from low to undetected. Expression at moderate levels in the following post-embryonic organs or tissues: adult central nervous system. Gene sequence location is 2R:13104005..13266470.
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2011_10	Clones 78876 EP14358 CK01.63A.E6 EK056456 CK01.76D.G5 EK009214 EK093063 CK01.71A.F8 CK01.121D.H6 EK160540 45226 MIP22634 EK153409 CK01.6A.D3 CK01.106A.H6 EK088563 Polypeptides mbl-PQ mbl-PN mbl-PP mbl-PO Transcripts mbl-RQ mbl-RO mbl-RP mbl-RN References Knowles-Barley, 2011.8.24, BrainTrap expression curation.
FB2012_01	Clones MIP22406 References García-López et al., 2011, Proc. Natl. Acad. Sci. U.S.A. 108(29): 11866--11871 Carreira et al., 2011, BMC Dev. Biol. 11: 32 Zwarts et al., 2011, Proc. Natl. Acad. Sci. U.S.A. 108(41): 17070--17075 Cunha et al., 2010, PLoS Genet. 6: e1001014 Sequence features BKN46168 HFA05657 BKN27778 HFA07651 HFA06449
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 54B1-54B5   Limits computationally determined from genome sequence between P{PZ}l(2)0712907129&P{PZ}mbl01038 and P{EP}EP1061&P{EP}cnkEP576
Experimentally Determined Cytological Location
Cytogenetic map Notes References 54A-54A     (Juni, 1999.9.1) 54B1-54B2     (Prokopenko, 1999.8.5) 54A1-54A3     (Paricio, 1997.4.29) 54A1-54A3     (Paricio, 1997.4.28) 54A1-54A3     (Begemann, 1997.4.15) 54B1-54B2   (determined by in situ hybridisation)   (Spradling et al., 1999) 54A-54A     (Juni et al., 1999) 54B1-54B2   (determined by in situ hybridisation)   (Semeshin et al., 1998) 54A1-54A3   (determined by in situ hybridisation)   (Begemann et al., 1997) 54A1-54A3   (determined by in situ hybridisation)   (Paricio, 1997.4.19) 54A-54A   (determined by in situ hybridisation)   (Kania et al., 1995) 54B1-54B2     (BDGP Project Members, 1994-1999)
Experimentally Determined Recombination Data
Location	2- (Paricio et al., 1997)
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\mbl for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
	Annotated transcripts may not represent all possible combinations of alternative exons and/or alternative promoters. Gene model reviewed during 5.42 Noncanonical short transcripts for mbl containing a partial tandem exon 2 repetition are described in FBrf0193093. Gene merge based on mRNA data
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) mbl-RA FBtr0086991  NM_176212   2919   203 mbl-RB FBtr0086992  NM_176211   3842   297 mbl-RC FBtr0086993  NM_176213   4039   84 mbl-RD FBtr0086994  NM_176210   3958   243 mbl-RG FBtr0301482  NM_001169702   1559   77 mbl-RH FBtr0306601     5222   951 mbl-RI FBtr0306602     8247   313 mbl-RJ FBtr0306603     6774   789 mbl-RK FBtr0306604     4936   803 mbl-RL FBtr0306605     7340   391 mbl-RM FBtr0306606     4988   873 mbl-RN FBtr0310058     3831   535 mbl-RO FBtr0310059     3975   583 mbl-RP FBtr0310346     4193   667 mbl-RQ FBtr0310347     4074   697
Additional Transcript Data & Comments
Reported size (kB)	3.846, 3.037, 2.990, 2.936 (longest cDNA) (Begemann et al., 1997)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein mbl-PA   FBpp0086143   22.7   203   9.55     NP_788392   AAO41359 mbl-PB   FBpp0086144   32.3   297   9.16     NP_788391   AAO41358 mbl-PC   FBpp0086145   9.6   84   8.38     NP_788393   AAO41360 mbl-PD   FBpp0086146   26.9   243   9.47     NP_788390   AAO41357 mbl-PG   FBpp0290697   8.6   77   8.33     NP_001163173   ACZ94445 mbl-PH   FBpp0297556   99.5   951   8.06       mbl-PI   FBpp0297557   33.7   313   9.68       mbl-PJ   FBpp0297558   82.5   789   7.53       mbl-PK   FBpp0297559   84.2   803   7.30       mbl-PL   FBpp0297560   42.2   391   9.42       mbl-PM   FBpp0297561   91.0   873   7.63       mbl-PN   FBpp0301759   58.2   535   8.84       mbl-PO   FBpp0301760   63.4   583   8.55       mbl-PP   FBpp0302029   71.9   667   8.55       mbl-PQ   FBpp0302030   75.1   697   8.83
Additional Polypeptide Data & Comments
Reported size (kDa)	316, 243, 203, 84 (aa) (Begemann et al., 1997)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Zinc finger, CCCH-type (IPR000571)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA567397   AA695692   AA696968   AA697537   AA698142   AA698266   AA698406   AA699286   AA801652   AE013599 AAO41357   AE013599 AAO41358   AE013599 AAO41359   AE013599 AAO41360   AB036794   AE013599 ACZ94445   AF001422 AAC01948   AF001536 AAC01949   AF001625 AAC47757   AF001626 AAC47758   AF175949   AF175950   AF175951   AF175952   AI063351   AI063381   AI107689   AI107943   AI113444   AI134977   AI238030   AI238172   AI257291   AI257513   AI257550   AI257730   AI258857   AI259834   AI259889   AI260504   AI261152   AI293019   AI293168   AI294011   AI294193   AI294391   AI295519   AI297186   AI387585   AI404153   AI406131   AI516928   AI517017   AI517325   AI531608   AI532745   AI533244   AI534123   AI534273   AI534592   AI534930   AI542234   AI542235   AI542523   AI543088   AI543200   AI543455   AQ025584   AQ025815   AQ034133   AW940611   AY089650   AY089662   BE978777   BG632011   BG632325   BG636039   BG641393   BI167919   BI168019   BI168164   BI170293   BI170847   BI172908   BI214816   BI215283   BI215374   BI227597   BI227635   BI236401   BI237587   BI238254   BI239895   BI363513   BI372395   BI374263   BI482625   BI482661   BI484605   BI565498   BI567733   BI571083   BI572036   BI572114   BI575675   BI577403   BI577737   BI583498   BI584544   BI587999   BI588462   BI589204   BI592160   BI593491   BI606034   BI606428   BI610993   BI611176   BI611279   BI613115   BI613209   BI613274   BI613581   BI616469   BI616860   BI617077   BI623047   BI628351   BI628385   BI628453   BI628593   BI629126   BI630637   BI632500   BI633327   BI633715   BI635066   BI635340   BI635522   BI635690   BI635718   BI635939   BI637349   BI637631   BI637730   BI637753   BI638148   BI638154   BI641482   BI641727   BI641956   BP543423   BP543424   BP548165   BP551648   BP553342   BP553343   BP560345   BT011050   BT024254   BT031021   BT124924   BT132664   BX029807   BZ665638   CK131504   CK132192   CK656963   CK657249   CK657590   CK659243   CK659578   CK659590   CK659681   CK660732   CK661116   CK661571   CK661903   CK661941   CK662076   CK662307   CK662482   CO152804   CO152948   CO153526   CO154046   CO154126   CO154251   CO154629   CO154640   CO154705   CO154880   CO154925   CO155342   CO155543   CO155583   CO155652   CO155672   CO155685   CO156116   CO156813   CO156877   CO157078   CO177240   CO177378   CO178347   CO178862   CO180689   CO180733   CO180964   CO180972   CO185408   CO186293   CO188319   CO188790   CO188926   CO191946   CO263458   CO263795   CO264032   CO264070   CO264249   CO265711   CO268743   CO268919   CO270000   CO273690   CO273941   CO276003   CO278876   CO279493   CO279675   CO280210   CO280755   CO282467   CO282479   CO282961   CO283387   CO285596   CO285728   CO287422   CO287518   CO288808   CO292338   CO292717   CO292830   CO293636   CO296976   CO297894   CO299400   CO299653   CO299708   CO299762   CO302522   CO306127   CO307470   CO307627   CO308336   CO308706   CO311789   CO312439   CO312958   CO313625   CO313668   CO314955   CO315454   CO317136   CO317548   CO319250   CO321394   CO322056   CO322058   CO322242   CO323368   CO323864   CO324062   CO324209   CO324380   CO325924   CO326270   CO327126   CO327498   CO328438   CO328741   CO328834   CO328936   CO328992   CO331470   CO335518   CO335567   CO335909   CO336076   CO336208   CO336590   CO337332   CO337536   CO337559   CO337826   CO337915   CO337961   CO338185   CO338385   CO338387   CO338436   CO338454   CO338470   CO338543   CO338928   CO340841   CO342197   CO342249   CO342279   CO342403   CZ469838   CZ470252   CZ470354   CZ478057   CZ478634   CZ478955   CZ488218   CZ489367   CZ489383   EC058120   EC063563   EC065510   EC065793   EC066135   EC066779   EC070828   EC071999   EC072343   EC072458   EC073689   EC075125   EC077636   EC078126   EC081141   EC082523   EC085088   EC086180   EC088121   EC088788   EC088975   EC195694   EC195865   EC197191   EC198431   EC198894   EC202237   EC203800   EC207133   EC211250   EC211304   EC211318   EC211731   EC214625   EC215686   EC216476   EC221384   EC222597   EC223681   EC225623   EC229795   EC230385   EC230415   EC231689   EC232843   EC233513   EC233793   EC233970   EC234065   EC235628   EC235747   EC238359   EC240384   EC244093   EC244216   EC244640   EC245248   EC245971   EC247506   EC248448   EC249406   EC250196   EC252231   EC252232   EC255229   EC256817   EC261471   EC262278   EL884467   EL886427   EL886709   GH944022   GH945471   GH948811   GH950256   GH951432   GH954271   GH955926   GH957133   GH960202   GH960276   GH960508   GH961231   GH961255   GH963453   GH964828   GH965921   GH967781   GH973618   GH977208   GH979077   GH982953
UniProtKB/Swiss-Prot	O16011
UniProtKB/TrEMBL
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
in situ Stage Tissue/Position (including subcellular localization) Reference larval stage   eye disc   (Begemann et al., 1997)
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
Polypeptide Expression
immunolocalization Stage Tissue/Position (including subcellular localization) Reference larval stage   imaginal disc   (Begemann et al., 1997) early ommatidial precursor cluster   (Begemann et al., 1997)
Additional Descriptive Data
	mbl protein is detected in the nuclei of ommatidial precluster cells and at lower levels in the nuclei of all imaginal disc cells. (Begemann et al., 1997)
Marker for
Subcellular Localization
CV Term	nucleus (Begemann et al., 1997)
Notes
High-Throughput Expression Data
or
See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes. modENCODE Temporal Expression Data for FBgn0261642    Styles Linear Logarithmic Heatmap    Scales max expr for FBgn0261642 Very low expression bin max Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderate expression to a trough of very low expression. Peak expression observed within 12-24 hour embryonic stages, at stages throughout the pupal period. [download data (TSV)] Guide to modENCODE expression level colors   No expression (0 - 0)   Extremely low expression (1 - 10)   Very low expression (11 - 100)   Low expression (101 - 400)   Moderate expression (401 - 1400)   Moderately high expression (1401 - 4000)   High expression (4001 - 10000)   Very high expression (10001 - 100000)   Extremely high expression (100001 - 2000000) Linear, scaled to maximum FBgn0261642 expression level Developmental Stage   Expression Level embryo 00-02hr    17 embryo 02-04hr    24 embryo 04-06hr    17 embryo 06-08hr    104 embryo 08-10hr    275 embryo 10-12hr    259 embryo 12-14hr    629 embryo 14-16hr    761 embryo 16-18hr    772 embryo 18-20hr    647 embryo 20-22hr    459 embryo 22-24hr    515 larva L1    377 larva L2    264 larva L3 12hr old    271 larva L3 puffstage 1-2    122 larva L3 puffstage 3-6    289 larva L3 puffstage 7-9    292 white prepupae new    337 white prepupae 12hr    400 white prepupae 24hr    447 pupae 2d postWPP    658 pupae 3d postWPP    467 pupae 4d postWPP    231 adult male 01day    318 adult male 05day    355 adult male 30day    377 adult female 01day    174 adult female 05day    71 adult female 30day    84 Expression Level Scale  None   Extremely low   Very low   Low   Moderate  Linear, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr    17 embryo 02-04hr    24 embryo 04-06hr    17 embryo 06-08hr  104 embryo 08-10hr  (275) embryo 10-12hr  (259) embryo 12-14hr  (629) embryo 14-16hr  (761) embryo 16-18hr  (772) embryo 18-20hr  (647) embryo 20-22hr  (459) embryo 22-24hr  (515) larva L1  (377) larva L2  (264) larva L3 12hr old  (271) larva L3 puffstage 1-2  (122) larva L3 puffstage 3-6  (289) larva L3 puffstage 7-9  (292) white prepupae new  (337) white prepupae 12hr  (400) white prepupae 24hr  (447) pupae 2d postWPP  (658) pupae 3d postWPP  (467) pupae 4d postWPP  (231) adult male 01day  (318) adult male 05day  (355) adult male 30day  (377) adult female 01day  (174) adult female 05day    71 adult female 30day    84 Expression Level Scale  None   Extremely low   Very low   Low  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    17 embryo 02-04hr    24 embryo 04-06hr    17 embryo 06-08hr    104 embryo 08-10hr    275 embryo 10-12hr    259 embryo 12-14hr    629 embryo 14-16hr    761 embryo 16-18hr    772 embryo 18-20hr    647 embryo 20-22hr    459 embryo 22-24hr    515 larva L1    377 larva L2    264 larva L3 12hr old    271 larva L3 puffstage 1-2    122 larva L3 puffstage 3-6    289 larva L3 puffstage 7-9    292 white prepupae new    337 white prepupae 12hr    400 white prepupae 24hr    447 pupae 2d postWPP    658 pupae 3d postWPP    467 pupae 4d postWPP    231 adult male 01day    318 adult male 05day    355 adult male 30day    377 adult female 01day    174 adult female 05day    71 adult female 30day    84 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    17 embryo 02-04hr    24 embryo 04-06hr    17 embryo 06-08hr    104 embryo 08-10hr    275 embryo 10-12hr    259 embryo 12-14hr    629 embryo 14-16hr    761 embryo 16-18hr    772 embryo 18-20hr    647 embryo 20-22hr    459 embryo 22-24hr    515 larva L1    377 larva L2    264 larva L3 12hr old    271 larva L3 puffstage 1-2    122 larva L3 puffstage 3-6    289 larva L3 puffstage 7-9    292 white prepupae new    337 white prepupae 12hr    400 white prepupae 24hr    447 pupae 2d postWPP    658 pupae 3d postWPP    467 pupae 4d postWPP    231 adult male 01day    318 adult male 05day    355 adult male 30day    377 adult female 01day    174 adult female 05day    71 adult female 30day    84 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    17 embryo 02-04hr    24 embryo 04-06hr    17 embryo 06-08hr    104 embryo 08-10hr    275 embryo 10-12hr    259 embryo 12-14hr    629 embryo 14-16hr    761 embryo 16-18hr    772 embryo 18-20hr    647 embryo 20-22hr    459 embryo 22-24hr    515 larva L1    377 larva L2    264 larva L3 12hr old    271 larva L3 puffstage 1-2    122 larva L3 puffstage 3-6    289 larva L3 puffstage 7-9    292 white prepupae new    337 white prepupae 12hr    400 white prepupae 24hr    447 pupae 2d postWPP    658 pupae 3d postWPP    467 pupae 4d postWPP    231 adult male 01day    318 adult male 05day    355 adult male 30day    377 adult female 01day    174 adult female 05day    71 adult female 30day    84 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  log, scaled to maximum FBgn0261642 expression level Developmental Stage   Expression Level embryo 00-02hr    17 embryo 02-04hr    24 embryo 04-06hr    17 embryo 06-08hr    104 embryo 08-10hr    275 embryo 10-12hr    259 embryo 12-14hr    629 embryo 14-16hr    761 embryo 16-18hr    772 embryo 18-20hr    647 embryo 20-22hr    459 embryo 22-24hr    515 larva L1    377 larva L2    264 larva L3 12hr old    271 larva L3 puffstage 1-2    122 larva L3 puffstage 3-6    289 larva L3 puffstage 7-9    292 white prepupae new    337 white prepupae 12hr    400 white prepupae 24hr    447 pupae 2d postWPP    658 pupae 3d postWPP    467 pupae 4d postWPP    231 adult male 01day    318 adult male 05day    355 adult male 30day    377 adult female 01day    174 adult female 05day    71 adult female 30day    84 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  log, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr    17 embryo 02-04hr    24 embryo 04-06hr    17 embryo 06-08hr  104 embryo 08-10hr  (275) embryo 10-12hr  (259) embryo 12-14hr  (629) embryo 14-16hr  (761) embryo 16-18hr  (772) embryo 18-20hr  (647) embryo 20-22hr  (459) embryo 22-24hr  (515) larva L1  (377) larva L2  (264) larva L3 12hr old  (271) larva L3 puffstage 1-2  122 larva L3 puffstage 3-6  (289) larva L3 puffstage 7-9  (292) white prepupae new  (337) white prepupae 12hr  (400) white prepupae 24hr  (447) pupae 2d postWPP  (658) pupae 3d postWPP  (467) pupae 4d postWPP  (231) adult male 01day  (318) adult male 05day  (355) adult male 30day  (377) adult female 01day  (174) adult female 05day    71 adult female 30day    84 Expression Level Scale  None   Extremely low   Very low   Low  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    17 embryo 02-04hr    24 embryo 04-06hr    17 embryo 06-08hr    104 embryo 08-10hr    275 embryo 10-12hr    259 embryo 12-14hr    629 embryo 14-16hr    761 embryo 16-18hr    772 embryo 18-20hr    647 embryo 20-22hr    459 embryo 22-24hr    515 larva L1    377 larva L2    264 larva L3 12hr old    271 larva L3 puffstage 1-2    122 larva L3 puffstage 3-6    289 larva L3 puffstage 7-9    292 white prepupae new    337 white prepupae 12hr    400 white prepupae 24hr    447 pupae 2d postWPP    658 pupae 3d postWPP    467 pupae 4d postWPP    231 adult male 01day    318 adult male 05day    355 adult male 30day    377 adult female 01day    174 adult female 05day    71 adult female 30day    84 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    17 embryo 02-04hr    24 embryo 04-06hr    17 embryo 06-08hr    104 embryo 08-10hr    275 embryo 10-12hr    259 embryo 12-14hr    629 embryo 14-16hr    761 embryo 16-18hr    772 embryo 18-20hr    647 embryo 20-22hr    459 embryo 22-24hr    515 larva L1    377 larva L2    264 larva L3 12hr old    271 larva L3 puffstage 1-2    122 larva L3 puffstage 3-6    289 larva L3 puffstage 7-9    292 white prepupae new    337 white prepupae 12hr    400 white prepupae 24hr    447 pupae 2d postWPP    658 pupae 3d postWPP    467 pupae 4d postWPP    231 adult male 01day    318 adult male 05day    355 adult male 30day    377 adult female 01day    174 adult female 05day    71 adult female 30day    84 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    17 embryo 02-04hr    24 embryo 04-06hr    17 embryo 06-08hr    104 embryo 08-10hr    275 embryo 10-12hr    259 embryo 12-14hr    629 embryo 14-16hr    761 embryo 16-18hr    772 embryo 18-20hr    647 embryo 20-22hr    459 embryo 22-24hr    515 larva L1    377 larva L2    264 larva L3 12hr old    271 larva L3 puffstage 1-2    122 larva L3 puffstage 3-6    289 larva L3 puffstage 7-9    292 white prepupae new    337 white prepupae 12hr    400 white prepupae 24hr    447 pupae 2d postWPP    658 pupae 3d postWPP    467 pupae 4d postWPP    231 adult male 01day    318 adult male 05day    355 adult male 30day    377 adult female 01day    174 adult female 05day    71 adult female 30day    84 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     FlyAtlas Anatomical Expression Data for FBgn0261642    Styles Linear Logarithmic Heatmap Back-to-back    Scales max expr for FBgn0261642 Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Two or more Affy2 ProbeSets identify exons of this gene. This is a summary of the tissue expression peaks exhibited in at least one of these ProbeSets. Expression in all larval and adult organs/tissues ranges from low to undetected. Expression at moderate levels in the following post-embryonic organs or tissues: adult central nervous system. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (1000 - 25000) Heatmap Tissue   Expression Level Larval Central Nervous System no informative data Larval Midgut no informative data Larval Hindgut no informative data Larval Malpighian Tubules no informative data Larval Fat Body     Larval Salivary Gland no informative data Larval Trachea no informative data Larval Carcass no informative data Adult Head no informative data Adult Eye no informative data Adult Brain no informative data Adult Thoracic-Abdominal Ganglion no informative data Adult Crop no informative data Adult Midgut no informative data Adult Hindgut no informative data Adult Malpighian Tubules no informative data Adult Fat Body no informative data Adult Salivary Gland no informative data Adult Heart no informative data Adult VirginFemale Spermatheca no informative data Adult InseminatedFemale Spermatheca no informative data Adult Ovary     Adult Testis     Adult Male Accessory Gland no informative data Adult Carcass no informative data modENCODE Temporal Expression Data (Graveley et al., 2011) FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
Expression Clusters
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0053197
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele lethal (with mblchst-exC3) mblchst-exC45 mblchst-exC110 mblchst-exS31 mblE27 mblE127 mblk05507b lethal (with mblchst-exC45) mblchst-exC3 mblE27 mblE127 mblk05507b lethal (with mblchst-exC110) mblchst-exC3 mblE27 mblE127 mblk05507b lethal (with mblchst-exS31) mblchst-exC3 mblE27 mblE127 mblk05507b lethal (with mblE27) mblchst-exC3 mblchst-exC45 mblchst-exC110 mblchst-exS31 mblE127 mblk05507b lethal (with mblE127) mblchst-exC3 mblchst-exC45 mblchst-exC110 mblchst-exS31 mblE27 mblk05507b lethal (with mblk05507b) mblchst-exC3 mblchst-exC45 mblchst-exC110 mblchst-exS31 mblE27 mblE127 lethal | embryonic stage, with Scer\GAL4da.G32 mblB.Scer\UAS lethal | embryonic stage (with mblE16) mblE27 lethal | embryonic stage (with mblE27) mblE16 lethal | embryonic stage | recessive mblE2 mblE16 mblE27 mblk05507b lethal | recessive mbl01038 mbl2563 mblchst-exC3 mblchst-exC20 mblchst-exC24 mblchst-exC45 mblchst-exC92 mblchst-exC99 mblchst-exC110 mblchst-exS31 mblchst-exS86 mblE2 mblE27 mblE127 mblk01212 mblk05507b mblk07103 semi-lethal (with mblchst) mblE27 semi-lethal (with mblE27) mblchst mblE2563-12 mblk07110 semi-lethal (with mblE127) mblk07110 semi-lethal (with mblE2563-12) mblE27 mblk05507b semi-lethal (with mblk05507b) mblE2563-12 mblk07110 semi-lethal (with mblk07110) mblE27 mblE127 mblk05507b viable mblchst mblchst-exC16 mblchst-exC71 mblchst-exC100 mblchst-exS5 mblchst-exS14 mblchst-exS45 mblPP2 viable (with mblchst) mblchst-exC3 mblE127 mblE2563-12 mblk05507b mblk07103 mblk07110 viable (with mblchst-exC3) mblchst mblE2563-12 mblk07103 mblk07110 viable (with mblchst-exC45) mblE2563-12 mblk07103 mblk07110 viable (with mblchst-exC110) mblE2563-12 mblk07103 mblk07110 viable (with mblchst-exS31) mblE2563-12 mblk07103 mblk07110 viable (with mblE27) mblk07103 viable (with mblE127) mblchst mblE2563-12 mblk07103 viable (with mblE2563-12) mblchst mblchst-exC3 mblchst-exC45 mblchst-exC110 mblchst-exS31 mblE127 mblk07103 mblk07110 viable (with mblk05507b) mblchst mblk07103 viable (with mblk07103) mblchst mblchst-exC3 mblchst-exC45 mblchst-exC110 mblchst-exS31 mblE27 mblE127 mblE2563-12 mblk05507b mblk07110 viable (with mblk07110) mblchst mblchst-exC3 mblchst-exC45 mblchst-exC110 mblchst-exS31 mblE2563-12 mblk07103 Other Phenotypes Allele courtship behavior defective | female (with mblchst) mblchst-exC3 mblchst-exC18 mblchst-exC24 mblchst-exC45 mblchst-exC67 mblchst-exC71 mblchst-exC106 mblchst-exC110 mblE27 mblE127 mblk05507b mblk07103 mblk07110 courtship behavior defective | female (with mblchst-exC3) mblchst courtship behavior defective | female (with mblchst-exC18) mblchst courtship behavior defective | female (with mblchst-exC24) mblchst courtship behavior defective | female (with mblchst-exC45) mblchst courtship behavior defective | female (with mblchst-exC67) mblchst courtship behavior defective | female (with mblchst-exC71) mblchst courtship behavior defective | female (with mblchst-exC106) mblchst courtship behavior defective | female (with mblchst-exC110) mblchst courtship behavior defective | female (with mblE27) mblchst courtship behavior defective | female (with mblE127) mblchst courtship behavior defective | female (with mblk05507b) mblchst courtship behavior defective | female (with mblk07103) mblchst courtship behavior defective | female (with mblk07110) mblchst courtship behavior defective | female | recessive mblchst planar polarity defective, with Scer\GAL4hs.2sev mblA.Scer\UAS mblC.Scer\UAS visible, with Scer\GAL469B mblC.Scer\UAS visible, with Scer\GAL4ap-md544 mblA.Scer\UAS visible, with Scer\GAL4hs.2sev mblA.Scer\UAS mblC.Scer\UAS Phenotype manifest in Allele abdomen | embryonic stage (with mblE16) mblE27 abdomen | embryonic stage (with mblE27) mblE16 chordotonal organ | lateral mblk07103 eye, with Scer\GAL4hs.2sev mblA.Scer\UAS mblC.Scer\UAS eye photoreceptor cell mbl2563 mblE2 mblE27 eye photoreceptor cell, with Scer\GAL4hs.2sev mblC.Scer\UAS fascicle mblk07103 I band mblE16 mblE2 mblE27 ommatidium, with Scer\GAL4hs.2sev mblA.Scer\UAS mblC.Scer\UAS presumptive embryonic/larval peripheral nervous system mblk07103 rhabdomere R2 mblk05507b mblE127 mbl2563 mblE2 mblE27 rhabdomere R3 mblk05507b mblE127 mbl2563 mblE2 mblE27 rhabdomere R4 mblk05507b mblE127 mbl2563 mblE2 mblE27 rhabdomere R5 mblk05507b mblE127 mbl2563 mblE2 mblE27 striated muscle myosin thick filament mblE16 mblE2 mblE27 striated muscle thin filament mblE16 mblE2 mblE27 tendon cell mblE16 mblE2 mblE27 wing, with Scer\GAL469B mblC.Scer\UAS wing, with Scer\GAL4T80 mblB.Scer\UAS wing (with mblE27) mblk07103 wing (with mblk07103) mblE27 wing cell, with Scer\GAL4e22c mblC.Scer\UAS wing vein, with Scer\GAL4ap-md544 mblA.Scer\UAS wing vein, with Scer\GAL4T80 mblA.Scer\UAS wing vein (with mblE27) mblk07103 wing vein (with mblk07103) mblE27 wing vein | ectopic, with Scer\GAL469B mblC.Scer\UAS wing vein L4, with Scer\GAL4e22c mblC.Scer\UAS wing vein L5, with Scer\GAL4e22c mblC.Scer\UAS
Classical Alleles ( 54 )
For All Classical Alleles Show
Allele of mbl Class Mutagen Stocks Known lesion mblk01212 P-element activity 2 -- mblKG08885 P-element activity 2 -- mbl01038 P-element activity 1 Yes mblc05273 piggyBac transposase 1 -- mblc05916 piggyBac transposase 1 -- mblchst-exC3 Delta2-3 1 Yes mblchst 1 Yes mble00160 piggyBac transposase 1 -- mble01138 piggyBac transposase 1 -- mble02656 1 -- mblE127 P-element activity 1 Yes mblE27 P-element activity 1 Yes mblf05616 piggyBac transposase 1 -- mblf06670 piggyBac transposase 1 -- mblk07103 P-element activity 1 Yes mblk07110 P-element activity 1 -- mblMB06084 1 -- mblMI00139 1 -- mblMI00976 1 -- mblNP0420 1 -- mblNP1161 1 -- mbl2563 P-element activity 0 Yes mblc05785 piggyBac transposase 0 -- mblc05921b 0 -- mblc07147 0 -- mblchst-exC100 Delta2-3 0 Yes mblchst-exC106 Delta2-3 0 Yes mblchst-exC110 Delta2-3 0 Yes mblchst-exC16 Delta2-3 0 Yes mblchst-exC18 Delta2-3 0 Yes mblchst-exC1 Delta2-3 0 Yes mblchst-exC20 Delta2-3 0 Yes mblchst-exC24 Delta2-3 0 Yes mblchst-exC2 Delta2-3 0 Yes mblchst-exC45 Delta2-3 0 Yes mblchst-exC67 Delta2-3 0 Yes mblchst-exC71 Delta2-3 0 Yes mblchst-exC92 Delta2-3 0 Yes mblchst-exC99 Delta2-3 0 Yes mblchst-exS14 Delta2-3 0 Yes mblchst-exS31 Delta2-3 0 Yes mblchst-exS45 Delta2-3 0 Yes mblchst-exS5 Delta2-3 0 Yes mblchst-exS86 Delta2-3 0 Yes mblchst-r1 Delta2-3 0 Yes mblCPTI001991 piggyBac transposase 0 Yes mblCPTI003555 piggyBac transposase 0 Yes mble00790 piggyBac transposase 0 -- mblE16 P-element activity 0 Yes mblE2563-12 0 Yes mblE2 P-element activity 0 Yes mblf06658 piggyBac transposase 0 -- mblk05507b hypomorphic allele - genetic evidence P-element activity 0 Yes mblPP2 P-element activity 0 Yes
Alleles Carried on Transgenic Constructs ( 13 )
For All Alleles Carried on Transgenic Constructs Show
Allele of mbl Class Mutagen Stocks Known lesion mblGD13374 in vitro construct - RNAi in vitro construct - regulatory fusion 2 Yes mblJF03264 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes mblKK107778 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes mblA.GMR in vitro construct - regulatory fusion 0 Yes mblA.Scer\UAS in vitro construct - regulatory fusion 0 Yes mblA.sev in vitro construct - regulatory fusion 0 Yes mblB.GMR in vitro construct - regulatory fusion 0 Yes mblB.hs in vitro construct - regulatory fusion 0 Yes mblB.Scer\UAS in vitro construct - regulatory fusion 0 Yes mblB.sev in vitro construct - regulatory fusion 0 Yes mblC.hs in vitro construct - regulatory fusion 0 Yes mblC.Scer\UAS in vitro construct - regulatory fusion 0 Yes mblD.Scer\UAS in vitro construct - regulatory fusion 0 Yes
Aneuploid Aberrations
Disrupted in	Df(2R)BSC44 (Bloomington Drosophila Stock Center, 2003.12.2) Df(2R)BSC49 (Deal-Herr and Cook, 2004.1.20) Df(2R)Exel6066 (Ryder, 2004.4.26) Df(2R)Exel7147 (Ryder, 2004.4.26) In(2R)k05507 (BDGP Project Members, 1994-1999)
Not disrupted in	Df(2R)42 (BDGP Project Members, 1994-1999) Df(2R)cn88b (BDGP Project Members, 1994-1999)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data heat-shock construct P{hs-mblB} NA P{hs-mblC} NA UAS construct P{GD13374} NA P{KK107778} NA P{TRiP.JF03264} NA P{UAS-mbl.B} NA
Insertions
	Type of insertions Name Expression data insertion of enhancer trap P{lacW}l(2)SH2036SH2036 No P{lacW}mbl2563 No P{lacW}mblk01212 No P{lacW}mblk05507b No P{lacW}mblk07103 No P{lacW}mblk07110 No P{lArB}mblPP2 No P{PZ}l(2)0712907129 No P{PZ}mbl01038 No miscellaneous insertions Mi{MIC}mblMI00139 NA Mi{MIC}mblMI00976 NA P{?BmΔ-w}mblchst-exC18 NA P{?BmΔ-w}mblchst-exC67 NA P{?BmΔ-w}mblchst-exC106 NA P{BmΔ-w}mblchst NA P{SUPor-P}mblKG08885 NA PBac{681.P.FSVS-1}mblCPTI001991 NA PBac{768.FSVS-0}mblCPTI003555 NA PBac{PB}mblc05273 NA PBac{PB}mblc05785 NA PBac{PB}mblc05916 NA PBac{PB}mblc05921b NA PBac{PB}mblc07147 NA PBac{RB}mble00160 NA PBac{RB}mble00790 NA PBac{RB}mble01138 NA PBac{RB}mble02656 NA PBac{WH}mblf05616 NA PBac{WH}mblf06658 NA PBac{WH}mblf06670 NA insertion of enhancer trap binary system Mi{ET1}mblMB06084 No P{GawB}mblNP0420 No P{GawB}mblNP1161 No
Gene Ontology: Function, Process & Cellular Component ( 13 unique terms )
Terms Based on Experimental Evidence ( 8 terms )
Molecular Function ( 0 terms)
Biological Process
CV term Evidence References
apoptotic process inferred from direct assay (Vicente-Crespo et al., 2008) compound eye photoreceptor cell differentiation inferred from mutant phenotype (Begemann et al., 1997) embryo development inferred from mutant phenotype (assigned by UniProtKB) (Begemann et al., 1997) muscle organ development inferred from mutant phenotype (assigned by UniProtKB) (Begemann et al., 1997) regulation of female receptivity inferred from mutant phenotype (Juni and Yamamoto, 2009)
Cellular Component
CV term Evidence References
cytoplasm inferred from direct assay (Fernandez-Costa and Artero, 2010) nucleus inferred from direct assay (Fernandez-Costa and Artero, 2010) inferred from direct assay (assigned by UniProtKB) (Begemann et al., 1997) perinuclear region of cytoplasm inferred from direct assay (Fernandez-Costa and Artero, 2010)
Terms Based on Predictions or Assertions ( 8 terms )
Molecular Function
CV term Evidence References
DNA binding traceable author statement (Prokopenko et al., 2000) nucleic acid binding inferred from electronic annotation with InterPro:IPR000571 (FlyBase Curators et al., 2004-) non-traceable author statement (assigned by UniProtKB) (Begemann et al., 1997) zinc ion binding inferred from electronic annotation with InterPro:IPR000571 (FlyBase Curators et al., 2004-)
Biological Process
CV term Evidence References
compound eye photoreceptor cell differentiation non-traceable author statement (Juni, 1999.9.1, Swiss-Prot Project Members, 2002.3.1) traceable author statement (Prokopenko et al., 2000) peripheral nervous system development traceable author statement (Prokopenko et al., 2000) regulation of female receptivity non-traceable author statement (Billeter et al., 2002) somatic muscle development traceable author statement (Prokopenko et al., 2000)
Cellular Component
CV term Evidence References
nucleus non-traceable author statement (Swiss-Prot Project Members, 2002.3.1)
Sequence Ontology: Class of Gene
	gene   nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Protein-protein
Interacting group Assay References
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions mbl allele Gene References mbl2563 Jra (Begemann et al., 1997) mblA.sev svp (Begemann et al., 1997) mblB.sev svp (Begemann et al., 1997) mblE27 Jra (Begemann et al., 1997) svp (Begemann et al., 1997) mblE127 Jra (Begemann et al., 1997) mblk05507b Jra (Begemann et al., 1997) svp (Begemann et al., 1997) unspecified svp (Paricio et al., 1997)
External Data
Linkouts	DroID - A comprehensive database of gene and protein interactions. • FBgn0261642 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 36945
Orthologs
Genome-wide drosophilid orthologs	Dana\GF11449 Dere\GG20672 Dgri\GH21019 Dper\GL17250 Dsec\GM21767 Dvir\GJ21630 Dwil\GK17876 Dyak\GE11656
Curated drosophilid orthologs	Dpse\GA13012   Dpse\GA17359
Linkouts	OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • PB13598 PB10996 NV11130 LH21865 LH21856 ISCW014803 ISCW014804 ISCW001013 FBgn0229453 FBgn0219875 FBgn0208749 FBgn0183008 FBgn0183007 FBgn0176645 FBgn0250103 FBgn0250104 JGI_V11_51833 FBgn0157162 FBgn0154853 FBgn0141358 FBgn0112859 CPIJ002209 CPIJ002207 BGIBMGA005961 BGIBMGA005962 ACYPI006283 GB13919 AGAP011555 AGAP011554 AAEL001531 AAEL001527 PHUM586820 PHUM586930 GLEAN_14149
Stocks & Reagents
Stocks Listed in FlyBase ( 27 )
Bloomington	25317 w1118; Mi{ET1}mblMB06084
Harvard	- PBac{PB}mblc05273 - PBac{PB}mblc05916 - PBac{RB}mble00160 - PBac{RB}mble01138 - PBac{RB}mble02656 - PBac{WH}mblf05616 - PBac{WH}mblf06670
Kyoto	103612 w*; P{GawB}mblNP0420 / CyO
VDRC	v105486 P{KK107778}VIE-260B v28731 w1118; P{GD13374}v28731 v28732 w1118; P{GD13374}v28732
	More stocks available...
Genomic Clones ( 2 )
	BACR28O12 BACR48A11 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 380 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	RE67734 RH07382 RH25742 RH33825
Other clones	IP15861 MIP22406 MIP22634
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	GH01350 GH03103 GH03155 GH05506 GH05843 GH06559 GH09708 GH12578 GH14012 GH14173 GH16278 GH18146 GH23761 GH26336 GH27532 GH27637 GH28037 GM02076 GM04306 GM08816 HL01126 HL02733 HL03840 HL04073 HL04417 HL08090 LP02153 LP03339 LP03409 LP04393 LP05285 LP05607 LP05910 LP05952 LP06184 LP06726 LP07291 LP07513 LP07752 LP09178 LP11433 LP13525 LP16868 LP17435 LP17453 LP17610 LP19559 LP20276 LP21169 LP21694 LP21767 LP22030 LP22404 LP22737 LP22842 LP23389 LP24008 RE08421 RE08551 RE08733 RE11690 RE12447 RE15610 RE20945 RE21644 RE21758 RE24691 RE24739 RE32451 RE33836 RE34661 RE36512 RE48340 RE59347 RE61810 RE65339 RE65378 RE71071 RE71462 RH05901 RH07371 RH07451 RH09786 RH11572 RH17051 RH17329 RH17463 RH22126 RH23770 RH28968 RH29693 RH31447 RH31563 RH38292 RH42193 RH42315 RH42390 RH42765 RH46427 RH46966 RH47292 RH55113 RH56721 RH56761 RH56864 RH57068 RH57941 RH59918 RH63278 RH72114 RH72906 SD01220 SD02728 SD04346 SD04995 SD06638 SD07044 SD07502 SD08394 SD08395 SD08869 SD09683 SD09891 SD10211 SD12723 SD13621 SD16303 SD16663 SD16891 SD17116 SD17158 SD17481 SD19335 SD19684 SD19792 SD19822 SD20365 SD20373 SD24831 SD25303 SD25643 SD26294 SD27390 SD27862
Other clones	11337 15521 20805 28835 29251 29398 29505 31278 32016 33114 35056 39850 41639 43459 45226 45856 46983 50137 53436 54086 54262 56416 60212 64492 65045 71090 72306 72352 74089 78876 101621 105916 106691 107399 118866 124703 144243 145611 148567 148890 149263 153389 156345 158572 163966 166606 173063 214351.75 214409.82 214475.74 214509.6 273019 542847 558143 bs82g06 CK01.6A.D3 CK01.52B.F9 CK01.63A.E6 CK01.65A.A5 CK01.65C.C7 CK01.71A.F8 CK01.73B.F9 CK01.76D.G5 CK01.77C.H5 CK01.106A.H6 CK01.121B.A8 CK01.121D.H6 CK01.123A.D4 EC03305 EC03605 EC13256 EC13268 EC32466 EK009214 EK018502 EK039211 EK041922 EK042421 EK053003 EK053312 EK056456 EK057817 EK060531 EK065819 EK066059 EK069419 EK088563 EK092554 EK093063 EK097106 EK111923 EK112709 EK119362 EK131952 EK134727 EK135621 EK136446 EK137229 EK137323 EK138317 EK143439 EK153409 EK154764 EK160540 EK160555 EK161852 EK163023 EK169529 EK170843 EK175402 EK176057 EK176358 EK176502 EK184335 EK185608 EK187122 EK187125 EK187706 EK190327 EK191740 EK192440 EK193002 EK193421 EK199855 EK200820 EK201034 EK203936 EK215564 EK226501 EK228812 EK230808 EK233607 EK233705 EK238610 EK250321 EK254633 EK255125 EK257646 EK259146 EK261528 EK267205 EK268459 EK277440 EK291309 EK291506 EK291711 EK291816 EK299861 EN00461 EN00908 EN02304 EN03353 EN03539 EN03807 EN04508 EN04520 EN04631 EN04955 EN05038 EN05852 EN06303 EN06355 EN06509 EN06536 EN06551 EN07357 EN09346 EN09462 EN09906 EN10628 EN10733 EN11455 EN11755 EN12050 EN12838 EN14308 EN14739 EN14810 EN15355 EN15558 EN15658 EN16131 EN16663 EN16703 EN16812 EN16836 EN16858 EN17040 EP00332 EP02921 EP03541 EP05911 EP07402 EP09214 EP11436 EP14135 EP14301 EP14358 EP14838 FGC020D07 FGH124F12 FGM214A07 FGM223H09 FGX001B03 GH16081 IP15761 IP17654 IP17954 RP004064760 RP004089068 RP004116889 RP004158942 RP004173762 RP004193272 RP004215405 RP004230579 RP004247112 RP004254841 RP004298825 RP004378490 RP004462958 RP004485822 RP004499223 RP004514279 RP004537011 RP004537657 RP004544828 RP004546820 RP004547724
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0261642 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 36945 36946 44222
Antibody Information
	polyclonal (Begemann et al., 1997)
Other Information
Discoverer
Etymology
	Reflecting that the phenotype is the development of the visual system and the muscle the gene is named "mbl", "muscleblind". (Begemann et al., 1997)
Identification
Relationship to Other Genes
Source for database identity of
Source for database merge of	Source for merge of: mbl chaste (Juni and Yamamoto, 2009) Source for merge of: mbl l(2)01038 (Misra, 2000.8.25) Source for merge of: mbl mm (Prokopenko and Bellen, 1998.3.11) Source for merge of: mm l(2)k01212 (Spradling et al., 1999)
Additional comments	Annotations CG14477, CG10941 merged as CG33197 (mbl) in release 3 of the genome annotation. (FlyBase Genome Annotators, 2002-2003) "l(2)07129" may correspond to "mm"; the P{PZ} insertion in the "l(2)0712907129" allele maps 61bp upstream of the 5' end of the CT30649 transcript of "mm". However, "l(2)0712907129" complements "mmk07110" (these alleles are caused by P-element insertions at the same site, the elements are P{PZ} and P{lacW} respectively). (Misra, 2000.11.18) Relationship between "chaste" and "mm" is unclear. (Juni et al., 1999)
Other Comments
	Mef2 regulates mbl where they are coexpressed. (Artero et al., 1998) mbl function is required for tendon matrix deposition at muscle attachments and for Z-band formation. (Artero et al., 1998) Molecular analysis reveals the mbl locus is large and complex, giving rise to multiple different proteins with common 5' sequences but different carboxy termini. (Begemann et al., 1997) Mutant females persistently repel male approaches throughout their life. (Yamamoto et al., 1997)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_176210 NM_176211 NM_176212 NM_176213 NM_001169702 RefSeq (Proteins) • NP_788390 NP_788391 NP_788392 NP_788393 NP_001163173 DDBJ / EMBL / GenBank • AAC01948 AAC01949 AAC47757 AAC47758 AAO41357 AAO41358 AAO41359 AAO41360 AB036794 ACL83142 ACL83143 ACZ94445 AF001422 AF001536 AF001625 AF001626 AF175949 AF175950 AF175951 AF175952 AI293019 AQ025584 AQ025815 AQ034133 AW940611 BI484605 BZ665638 CZ469838 CZ470252 CZ470354 CZ478057 CZ478634 CZ478955 CZ488218 CZ489367 CZ489383 Entrez Gene - A searchable database of RefSeq genes. • 36945 UniProtKB/Swiss-Prot • O16011
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Zinc finger, CCCH-type (IPR000571)
Linkouts
	DroID - A comprehensive database of gene and protein interactions. • FBgn0261642 DRSC - Results from RNAi screens. • FBgn0261642 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0053197 FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0261642 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 36945 36946 44222 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 36945 modMine - Data generated by the modENCODE project. • FBgn0261642 OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • PB13598 PB10996 NV11130 LH21865 LH21856 ISCW014803 ISCW014804 ISCW001013 FBgn0229453 FBgn0219875 FBgn0208749 FBgn0183008 FBgn0183007 FBgn0176645 FBgn0250103 FBgn0250104 JGI_V11_51833 FBgn0157162 FBgn0154853 FBgn0141358 FBgn0112859 CPIJ002209 CPIJ002207 BGIBMGA005961 BGIBMGA005962 ACYPI006283 GB13919 AGAP011555 AGAP011554 AAEL001531 AAEL001527 PHUM586820 PHUM586930 GLEAN_14149
Synonyms & Secondary IDs ( 17 )
Reported As
Symbol Synonym	CG10941   CG14477 (BDGP Project Members, 2000-, ) CG33197 (Keleman et al., 2009.8.5, Perkins et al., 2009, Ellis and Carney, 2011) chaste (Juni, 1999.9.1, ) chst (Juni and Yamamoto, 2009) cht (Billeter et al., 2002, Nakano et al., 1999, Yamamoto et al., 1998, Yamamoto and Nakano, 1998, Yamamoto et al., 1997) l(2)01038 (Spradling et al., 1999, Zaiss and Belote, 1997, Artero, 1995.11.17, ) l(2)k01212 (Spradling et al., 1999, BDGP Project Members, 1994-1999, ) l(2)k05507 (Begemann et al., 1997) mbl (Garcia-Lopez et al., 2008, Aerts et al., 2007, Juni and Yamamoto, 2009, Edwards et al., 2006, Machuca-Tzili et al., 2006, Kucherenko et al., 2008, Nallamothu and Hsu, 2008, Sandmann et al., 2006, Li et al., 2008, Monferrer and Artero, 2006, Houseley et al., 2006, Vicente et al., 2007, Zeitlinger et al., 2007, Goers et al., 2008, de Haro et al., 2006, Morozova et al., 2007, Ellis and Carney, 2011, Cunha et al., 2010) Mbl (Fernandez-Costa and Artero, 2010) mm (Harbison et al., 2004, Deal-Herr and Cook, 2004.1.20, Prokopenko et al., 2000, Prokopenko, 1999.8.5, Prokopenko and Bellen, 1998.3.11, Kania et al., 1995, Giot et al., 2003, ) n(2)k07110 (Spradling, 1999.12.9) unnamed (Robertson, 2001.5.6)
Name Synonym	chaste (Yamamoto et al., 1997, Juni and Yamamoto, 2009) mindmelt (Huntley and Golding, 2004, ) Muscleblind (Garcia-Lopez et al., 2008, Vicente-Crespo et al., 2008, Frasch, 1999, Nallamothu and Hsu, 2008) muscleblind (Edwards et al., 2006, Robin et al., 2007, Burnette, 2005, Machuca-Tzili et al., 2006, Li et al., 2008, Monferrer and Artero, 2006, Houseley et al., 2006, Vicente et al., 2007, Goers et al., 2008, Houseley et al., 2005, Juni and Yamamoto, 2009, Morozova et al., 2007, Jordan et al., 2007, Pascual et al., 2005, Fernandez-Costa and Artero, 2010)
Secondary FlyBase IDs
	FBgn0010471 FBgn0015514 FBgn0020274 FBgn0020555 FBgn0022250 FBgn0034208 FBgn0053197
References ( 97 )
Generate a list of	All references relating to this gene ( 97 )
List References by type	Research paper  ( 40 ) Supplementary material  ( 3 ) Review  ( 7 ) Personal communication to FlyBase  ( 22 ) Abstract  ( 11 ) FlyBase analysis  ( 3 ) Computer file  ( 4 ) DNA/RNA sequence record  ( 5 ) Protein sequence record  ( 1 )
Recent research papers ( 8 )
	Carreira et al., 2011, BMC Dev. Biol. 11: 32 Genetic basis of wing morphogenesis in Drosophila: sexual dimorphism and non-allometric effects of shape variation. [FBrf0214273] Ellis and Carney, 2011, Genetics 187(1): 157--169 Socially-Responsive Gene Expression in Male Drosophila melanogaster Is Influenced by the Sex of the Interacting Partner. [FBrf0212780] García-López et al., 2011, Proc. Natl. Acad. Sci. U.S.A. 108(29): 11866--11871 In vivo discovery of a peptide that prevents CUG-RNA hairpin formation and reverses RNA toxicity in myotonic dystrophy models. [FBrf0214380] Kucherenko et al., 2011, Dev. Biol. 352(2): 228--242 Stress and muscular dystrophy: a genetic screen for dystroglycan and dystrophin interactors in Drosophila identifies cellular stress response components. [FBrf0214383] Morozova et al., 2011, Genetics 187(4): 1193--1205 Transcriptional networks for alcohol sensitivity in Drosophila melanogaster. [FBrf0214377] Zwarts et al., 2011, Proc. Natl. Acad. Sci. U.S.A. 108(41): 17070--17075 Complex genetic architecture of Drosophila aggressive behavior. [FBrf0216413] Cunha et al., 2010, PLoS Genet. 6: e1001014 Combinatorial binding leads to diverse regulatory responses: Lmd is a tissue-specific modulator of Mef2 activity. [FBrf0211225] Fernandez-Costa and Artero, 2010, Mol. Cells 30(1): 65--70 A conserved motif controls nuclear localization of Drosophila Muscleblind. [FBrf0211364] Show all research papers ...
Recent reviews (0)
	All reviews listed in FlyBase were published before 2010 Show reviews ...