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Gene Dmel\gce

General Information
Symbol	Dmel\gce	Species	D. melanogaster
Name	germ cell-expressed bHLH-PAS	Annotation symbol	CG42739
Feature type	protein_coding_gene	FlyBase ID	FBgn0261703
Gene Model Status	Current	Stock availability	8 publicly available
Also Known As	CG6211, CG15032
Genomic Location
Chromosome (arm)	X	Recombination map
Cytogenetic map	13B6-13B6	Sequence location	X:15,191,798..15,213,107 [+]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents modENCODE GBrowse	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene germ cell-expressed bHLH-PAS is referred to in FlyBase by the symbol Dmel\gce (CG42739, FBgn0261703). It is a protein_coding_gene from Drosophila melanogaster. There is experimental evidence that it has the molecular function: transcription factor binding; protein heterodimerization activity. There is experimental evidence that it is involved in the biological process: positive regulation of transcription from RNA polymerase II promoter. 7 alleles are reported. No phenotypic data is available. It has 4 annotated transcripts and 4 annotated polypeptides. Protein features are: Helix-loop-helix DNA-binding; Nuclear translocator; PAC motif; PAS; PAS fold-3. Gene sequence location is X:15191798..15213107.
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2011_10	References Svetec et al., 2009, Mol. Biol. Evol. 26(7): 1549--1556 Polypeptides gce-PF gce-PE Clones CK01.60A.A10 EK047426 EK066029 119540 Transcripts gce-RF gce-RE
FB2012_01	Controlled Vocabulary Terms positive regulation of transcription from RNA polymerase II promoter protein heterodimerization activity transcription factor binding References Li et al., 2011, Proc. Natl. Acad. Sci. U.S.A. 108(2): 638--643 Dubrovsky et al., 2011, J. Biol. Chem. 286(38): 33689--33700 Sequence features BKN32917 BKN29764 HFA19613 HFA19974
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 13B6-13B6   Limits computationally determined from genome sequence between P{EP}hiwEP1308 and P{EP}Ahcy13EP1007
Experimentally Determined Cytological Location
Cytogenetic map Notes References
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\gce for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
	Gene model reviewed during 5.42 Gene merge based on RNA-Seq data.
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) gce-RC FBtr0303198  NM_078605   5524   959 gce-RD FBtr0303199  NM_001201664   5063   959 gce-RE FBtr0310308     5121   959 gce-RF FBtr0310309     5186   918
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein gce-PC   FBpp0292296   105.8   959   6.20     NP_511160   AAF48439 gce-PD   FBpp0292297   105.8   959   6.20     NP_001188593   ADV37675 gce-PE   FBpp0301991   105.8   959   6.20       gce-PF   FBpp0301992   101.1   918   6.35
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • PAS (IPR000014) Nuclear translocator (IPR001067) Helix-loop-helix DNA-binding (IPR011598) PAS fold-3 (IPR013655) PAC motif (IPR001610)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA567788   AE014298 AAF48439   AE014298 ADV37675   BI627073   BP546537   BT100238   BT132669   CO190222   CO262948   CO263024   CO277293   CO278306   CO286068   CO286131   CO286157   CO287502   CO287797   CO287879   CO288722   CO289343   CO291432   CO291481   CO300860   CO302229   DQ327768   DQ327769   EC061093   EC082083   EC083181   EC088437   EC195563   EC195950   EC195954   EC207539   EC207640   EC219521   EC230356   EC230524   EC231163   EC231186   EC234701   EC241384   EC242176   FL502704   FL502752
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL	Q9VXW7 Q9VXW8
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
Polypeptide Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
High-Throughput Expression Data
or
See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes. modENCODE Temporal Expression Data (Graveley et al., 2011) FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
Expression Clusters
External Data & Images
Linkouts
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele semi-lethal | pupal stage, with Scer\GAL4pnr-MD237 gceGD4350 gceGD8522 Phenotype manifest in Allele
Classical Alleles ( 2 )
For All Classical Alleles Show
Allele of gce Class Mutagen Stocks Known lesion gced03433 1 -- gceMI02742 1 --
Alleles Carried on Transgenic Constructs ( 5 )
For All Alleles Carried on Transgenic Constructs Show
Allele of gce Class Mutagen Stocks Known lesion gceGD4350 in vitro construct - RNAi in vitro construct - regulatory fusion 2 Yes gceGD8522 in vitro construct - RNAi in vitro construct - regulatory fusion 2 Yes gceJF02097 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes gceKK109764 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes gcedsRNA.Scer\UAS.cWa in vitro construct - RNAi 0 --
Aneuploid Aberrations
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD4350} NA P{KK109764} NA P{TRiP.JF02097} NA P{UAS-gce.RNAi} NA
Insertions
	Type of insertions Name Expression data miscellaneous insertions Mi{MIC}gceMI02742 NA P{SUPor-P}Top1KG02463 NA insertion of mobile activating element P{XP}gced03433 NA
Gene Ontology: Function, Process & Cellular Component ( 8 unique terms )
Terms Based on Experimental Evidence ( 3 terms )
Molecular Function
CV term Evidence References
protein heterodimerization activity inferred from physical interaction with ftz-f1 (Dubrovsky et al., 2011) transcription factor binding inferred from physical interaction with ftz-f1 (Dubrovsky et al., 2011)
Biological Process
CV term Evidence References
positive regulation of transcription from RNA polymerase II promoter inferred from mutant phenotype (Dubrovsky et al., 2011)
Cellular Component ( 0 terms)
Terms Based on Predictions or Assertions ( 5 terms )
Molecular Function
CV term Evidence References
sequence-specific DNA binding transcription factor activity inferred from sequence or structural similarity with Met (Peyrefitte et al., 2001) signal transducer activity inferred from electronic annotation with InterPro:IPR000014 (FlyBase Curators et al., 2004-)
Biological Process
CV term Evidence References
regulation of transcription, DNA-dependent inferred from sequence or structural similarity with Met (Peyrefitte et al., 2001) signal transduction inferred from electronic annotation with InterPro:IPR000014, InterPro:IPR001610 (FlyBase Curators et al., 2004-)
Cellular Component
CV term Evidence References
nucleus inferred by curator from GO:0003700 (Peyrefitte et al., 2001) inferred from electronic annotation with InterPro:IPR001067 (FlyBase Curators et al., 2004-)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Protein-protein
Interacting group Assay References
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions gce allele Gene References
External Data
Linkouts	DroID - A comprehensive database of gene and protein interactions. • FBgn0261703
Orthologs
Genome-wide drosophilid orthologs	Dana\GF19756 Dana\GF21231 Dere\GG17872 Dere\GG17873 Dgri\GH17616 Dmoj\GI21773 Dper\GL15998 Dper\GL15999 Dpse\GA19443 Dpse\GA24355 Dsec\GM19668 Dsec\GM19712 Dsim\GD17203 Dsim\GD17204 Dvir\GJ16946 Dwil\GK16199 Dwil\GK17951 Dyak\GE17174 Dyak\GE17175
Curated drosophilid orthologs	Dpse\GA19443
Linkouts	OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • NV10215 LH23949 ISCW008805 FBgn0234654 FBgn0218201 FBgn0204124 FBgn0188768 FBgn0174612 JGI_V11_247693 FBgn0079439 FBgn0153603 FBgn0144503 FBgn0125086 FBgn0110093 FBgn0098233 CPIJ014157 BGIBMGA005416 BGIBMGA000657 ACYPI31575 GB10201 AGAP006022 AAEL001746 PB22749 PHUM501200 GLEAN_03908
Stocks & Reagents
Stocks Listed in FlyBase ( 8 )
Bloomington	26323 y1 v1; P{TRiP.JF02097}attP2 35131 y1 w* Mi{MIC}gceMI02742
Harvard	- P{XP}gced03433
VDRC	v101814 P{KK109764}VIE-260B v11176 w1118 P{GD4350}v11176 v11178 w1118; P{GD4350}v11178 v47465 w1118; P{GD8522}v47465 v47467 w1118; P{GD8522}v47467
Genomic Clones ( 1 )
	BACR48D17 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 35 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones
Other clones	HL01770 LP18592
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones
Other clones	4768 17231 58201 119540 CK01.60A.A10 CK01.79B.G1 CK01.79D.C12 CK01.79D.H3 CK01.83D.H9 CK01.84C.H5 CK01.87D.G11 CK01.90A.F5 CK01.103C.C7 CK01.104A.D11 DMG4-chrX.28.001.pred.a EK047426 EK061625 EK061844 EK061930 EK066029 EK066829 EK067024 EK069228 EK070823 EK079312 EK079714 EK086912 EK087116 EK123738 EK129713 EK179542 EK183709 FGH107E01
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0261703 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 32456 32457
Antibody Information
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of	Source for identity of: gce CG6211 (Moore et al., 2000)
Source for database merge of	Source for merge of: gce CG15032 (FlyBase Genome Annotators, 2010)
Additional comments	Annotations CG6211 and CG15032 merged as CG42739 in release 5.27 of the genome annotation. (FlyBase Genome Annotators, 2010)
Other Comments
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_078605 NM_001201664 RefSeq (Proteins) • NP_511160 NP_001188593 DDBJ / EMBL / GenBank • AA567788 AAF48438 AAF48439 ABW09417 ADV37675 BI627073 DQ327768 DQ327769 Entrez Gene - A searchable database of RefSeq genes. • 32456 32457 UniProtKB/TrEMBL • Q9VXW7 Q9VXW8
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • PAS (IPR000014) Nuclear translocator (IPR001067) Helix-loop-helix DNA-binding (IPR011598) PAS fold-3 (IPR013655) PAC motif (IPR001610)
Linkouts
	DroID - A comprehensive database of gene and protein interactions. • FBgn0261703 DRSC - Results from RNAi screens. • FBgn0261703 FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0261703 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 32456 32457 modMine - Data generated by the modENCODE project. • FBgn0261703 OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • NV10215 LH23949 ISCW008805 FBgn0234654 FBgn0218201 FBgn0204124 FBgn0188768 FBgn0174612 JGI_V11_247693 FBgn0079439 FBgn0153603 FBgn0144503 FBgn0125086 FBgn0110093 FBgn0098233 CPIJ014157 BGIBMGA005416 BGIBMGA000657 ACYPI31575 GB10201 AGAP006022 AAEL001746 PB22749 PHUM501200 GLEAN_03908
Synonyms & Secondary IDs ( 10 )
Reported As
Symbol Synonym	CG6211 (Peyrefitte et al., 2001, Ledent and Vervoort, 2001, Moore et al., 2000, Perkins et al., 2009.3.31, Keleman et al., 2009.8.5, Baumann et al., 2010) CG15032 (Girard et al., 2006, Manak et al., 2006, Baumann et al., 2010, Svetec et al., 2009) CG42739 (FlyBase Genome Annotators, 2010) Dmgce (Wang et al., 2007) gce (Girard et al., 2006, Godlewski et al., 2006, Liu et al., 2009, Wang et al., 2007, Baumann et al., 2010, Dubrovsky et al., 2011) GCE (Li et al., 2011)
Name Synonym	germ-cell expressed (Godlewski et al., 2006, Wang et al., 2007, Dubrovsky et al., 2011) germ cell expressed (Baumann et al., 2010) germ cell-expressed bHLH-PAS (Moore et al., 2000, ) Germ-cell expressed bHLH-PAS (Liu et al., 2009)
Secondary FlyBase IDs
	FBgn0030626 FBgn0030627
References ( 27 )
Generate a list of	All references relating to this gene ( 27 )
List References by type	Research paper  ( 12 ) Supplementary material  ( 3 ) Personal communication to FlyBase  ( 5 ) FlyBase analysis  ( 3 ) Computer file  ( 2 ) Automatic genome annotation  ( 1 ) Curated genome annotation  ( 1 )
Recent research papers ( 4 )
	Dubrovsky et al., 2011, J. Biol. Chem. 286(38): 33689--33700 The Drosophila FTZ-F1 Nuclear Receptor Mediates Juvenile Hormone Activation of E75A Gene Expression through an Intracellular Pathway. [FBrf0215576] Li et al., 2011, Proc. Natl. Acad. Sci. U.S.A. 108(2): 638--643 Heterodimer of two bHLH-PAS proteins mediates juvenile hormone-induced gene expression. [FBrf0212776] Baumann et al., 2010, J. Insect Physiol. 56(10): 1445--1455 Evolutionary divergence of the paralogs Methoprene tolerant (Met) and germ cell expressed (gce) within the genus Drosophila. [FBrf0211455] Baumann et al., 2010, Genetics 185(4): 1327--1336 Paralogous Genes Involved in Juvenile Hormone Action in Drosophila melanogaster. [FBrf0211496] Show all research papers ...