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Gene Dmel\Cpn

General Information
Symbol	Dmel\Cpn	Species	D. melanogaster
Name	Calphotin	Annotation symbol	CG4795
Feature type	protein_coding_gene	FlyBase ID	FBgn0261714
Gene Model Status	Current	Stock availability	7 publicly available
Also Known As	cap
Genomic Location
Chromosome (arm)	3R	Recombination map	3-[51]
Cytogenetic map	87A9-87B5	Sequence location	3R:7,988,609..7,991,908 [-]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents Beta	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene Calphotin is referred to in FlyBase by the symbol Dmel\Cpn (CG4795, FBgn0261714). It is a protein_coding_gene from Drosophila melanogaster. There is experimental evidence that it has the molecular function: calcium ion binding. There is experimental evidence that it is involved in the biological process: rhabdomere development. 14 alleles are reported. The phenotype of these alleles is annotated with: trichogen cell. It has 2 annotated transcripts and 2 annotated polypeptides. Gene sequence location is 3R:7988609..7991908.
User Contributed Data
	Beta version, feedback welcome
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2013_03	Alleles Cpn[dsRNA.Scer\UAS.WIZ] Cpn[ninaE.T:Avic\GFP-EGFP] Transgenic Constructs P{ninaE-Cpn.GFP} P{UAS-Cpn.RNAi}
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 87A9-87B5   Left limit from in situ hybridisation (FBrf0050876) Right limit from in situ hybridisation (FBrf0050876)
Experimentally Determined Cytological Location
Cytogenetic map Notes References 87A-87B   Determined on the basis of RFLP's detected with Df(3R)T-47 and Df(3R)kar-Sz12 using cDNA as probe.   (Ballinger et al., 1993) 86E-87B   (determined by in situ hybridisation)   (Martin et al., 1993) 87A9-87B5   (determined by in situ hybridisation)   (Ballinger and Benzer, 1989)
Experimentally Determined Recombination Data
Location	3-[51]
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\Cpn for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
	Gene model reviewed during 5.49 Annotated transcripts do not represent all supported alternative splices within 5' UTR. Low-frequency RNA-Seq exon junction(s) not annotated.
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) Cpn-RA FBtr0082547  NM_169454   2787   842 Cpn-RB FBtr0082548  NM_169455   2853   864
Additional Transcript Data & Comments
Reported size (kB)	3 (northern blot) (Martin et al., 1993) 3.0 (northern blot) (Ballinger et al., 1993)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein Cpn-PA   FBpp0082020   82.2   842   3.31     NP_731673   AAF54755 Cpn-PB   FBpp0082021   84.6   864   3.32     NP_731674   AAF54754
Additional Polypeptide Data & Comments
Reported size (kDa)	873 (aa); 85 (kD) (Ballinger et al., 1993) 865 (aa); 85 (kD) (Martin et al., 1993)
Comments
External Data
Linkouts
Crossreferences
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA568088   AA698047   AA698970   AA698982   AE014297 AAF54754   AE014297 AAF54755   AI107583   AI108223   AI108764   AI108896   AI110041   AI113401   AI134487   AI135298   AI238838   AI292493   AI387079   AI387512   AI389621   AI402402   AI403181   AI403603   AI404579   AI516936   AI517351   AI517569   AW940288   AY058315 AAL13544   BI571300   BI571334   BI572086   BI572393   BT046129   CO186473   CO266317   CO277602   CO281015   CO282946   CO303510   CO308657   CO319318   CO319992   CO322825   DN154469   EC051251   EC051843   EC053351   EC054864   EC055840   EC058727   EC061194   EC061655   EC066893   EC072539   EC079917   EC084304   EC084485   EC198623   EC200615   EC203796   EC210988   EC226078   EC239130   EL874693   EL875058   EL884296   EL884428   L02111 AAA28405   L05080 AAA28420
UniProtKB/Swiss-Prot	Q02910
UniProtKB/TrEMBL
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
No Assay Recorded Stage Tissue/Position (including subcellular localization) Reference adult stage   head   (Ballinger et al., 1993) photoreceptor cell R1 -- photoreceptor cell R8   (Martin et al., 1993) in situ Stage Tissue/Position (including subcellular localization) Reference adult stage   ocellus   (Martin et al., 1993)
Additional Descriptive Data
	In adults, Cpn expression is head-specific. In eya mutants, which lack compound eyes, no expression is observed. (Ballinger et al., 1993) Cpn transcripts are found in photoreceptor cells and ocelli but not in photoreceptor axons or optic lobes. (Martin et al., 1993)
Marker for
Subcellular Localization
CV Term
Polypeptide Expression
No Assay Recorded Stage Tissue/Position (including subcellular localization) Reference adult stage   optic lobe   (Martin et al., 1993) immunolocalization Stage Tissue/Position (including subcellular localization) Reference larval stage & adult stage   ocellus   (Ballinger et al., 1993) third instar larval stage   eye-antennal disc   (Ballinger et al., 1993) adult stage   photoreceptor cell R1 -- photoreceptor cell R8   (Martin et al., 1993) ocellus   (Martin et al., 1993) western blot Stage Tissue/Position (including subcellular localization) Reference adult stage   adult head   (Weiss et al., 2012)
Additional Descriptive Data
	Cpn protein is detected in a defined cytoplasmic region that is relatively low in electron density. It occupies a part of the cell proximal to the rhabdomere and is not present in the rhabdomeres, nuclei, mitochondria, or rough ER. (Martin et al., 1993) Cpn protein is expressed in photoreceptor cell bodies and along their axons. (Ballinger et al., 1993)
Marker for
Subcellular Localization (GO Cellular Component)
CV term Evidence References
axon inferred from direct assay (Ballinger et al., 1993, Martin et al., 1993) cell body inferred from direct assay (Ballinger et al., 1993) cytoplasm inferred from direct assay (Weiss et al., 2012, Martin et al., 1993) NOT mitochondrion inferred from direct assay (Martin et al., 1993) NOT nucleus inferred from direct assay (Martin et al., 1993) NOT rhabdomere inferred from direct assay (Martin et al., 1993) NOT rough endoplasmic reticulum inferred from direct assay (Martin et al., 1993)
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools
Reference	See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes.
FlyAtlas Anatomy Microarray
FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
modENCODE Anatomy RNA-Seq
modENCODE Tissue Expression Data (modENCODE_mRNA-Seq_tissues)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    0 central nervous system, larvae L3    0 central nervous system, pupae P8    2 head, virgin 1-day female    238 head, virgin 4-day female    203 head, virgin 20-day female    125 head, mated 1-day female    195 head, mated 4-day female    128 head, mated 20-day female    110 head, mated 1-day male    315 head, mated 4-day male    202 head, mated 20-day male    145 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    0 digestive system, larvae L3 wandering    0 digestive system, 1-day adult    0 digestive system, 4-day adult    0 digestive system, 20-day adult    0 fat body, larvae L3 wandering    0 fat body, white prepupae    0 fat body, pupae P8    3 carcass, larvae L3 wandering    1 carcass, 1-day adult    0 carcass, 4-day adult    0 carcass, 20-day adult    0 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    0 accessory gland, mated 4-day male    0 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering    0 central nervous system, larvae L3    0 central nervous system, pupae P8    2 head, virgin 1-day female  (238) head, virgin 4-day female  (203) head, virgin 20-day female  (125) head, mated 1-day female  (195) head, mated 4-day female  (128) head, mated 20-day female  (110) head, mated 1-day male  (315) head, mated 4-day male  (202) head, mated 20-day male  (145) salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    0 digestive system, larvae L3 wandering    0 digestive system, 1-day adult    0 digestive system, 4-day adult    0 digestive system, 20-day adult    0 fat body, larvae L3 wandering    0 fat body, white prepupae    0 fat body, pupae P8    3 carcass, larvae L3 wandering    1 carcass, 1-day adult    0 carcass, 4-day adult    0 carcass, 20-day adult    0 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    0 accessory gland, mated 4-day male    0 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    0 central nervous system, larvae L3    0 central nervous system, pupae P8    2 head, virgin 1-day female  (238) head, virgin 4-day female  (203) head, virgin 20-day female  (125) head, mated 1-day female  (195) head, mated 4-day female  (128) head, mated 20-day female  (110) head, mated 1-day male  (315) head, mated 4-day male  (202) head, mated 20-day male  (145) salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    0 digestive system, larvae L3 wandering    0 digestive system, 1-day adult    0 digestive system, 4-day adult    0 digestive system, 20-day adult    0 fat body, larvae L3 wandering    0 fat body, white prepupae    0 fat body, pupae P8    3 carcass, larvae L3 wandering    1 carcass, 1-day adult    0 carcass, 4-day adult    0 carcass, 20-day adult    0 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    0 accessory gland, mated 4-day male    0 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    0 central nervous system, larvae L3    0 central nervous system, pupae P8    2 head, virgin 1-day female    238 head, virgin 4-day female    203 head, virgin 20-day female    125 head, mated 1-day female    195 head, mated 4-day female    128 head, mated 20-day female    110 head, mated 1-day male    315 head, mated 4-day male    202 head, mated 20-day male    145 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    0 digestive system, larvae L3 wandering    0 digestive system, 1-day adult    0 digestive system, 4-day adult    0 digestive system, 20-day adult    0 fat body, larvae L3 wandering    0 fat body, white prepupae    0 fat body, pupae P8    3 carcass, larvae L3 wandering    1 carcass, 1-day adult    0 carcass, 4-day adult    0 carcass, 20-day adult    0 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    0 accessory gland, mated 4-day male    0 Expression Level Scale  Extremely high  log, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    0 central nervous system, larvae L3    0 central nervous system, pupae P8    2 head, virgin 1-day female    238 head, virgin 4-day female    203 head, virgin 20-day female    125 head, mated 1-day female    195 head, mated 4-day female    128 head, mated 20-day female    110 head, mated 1-day male    315 head, mated 4-day male    202 head, mated 20-day male    145 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    0 digestive system, larvae L3 wandering    0 digestive system, 1-day adult    0 digestive system, 4-day adult    0 digestive system, 20-day adult    0 fat body, larvae L3 wandering    0 fat body, white prepupae    0 fat body, pupae P8    3 carcass, larvae L3 wandering    1 carcass, 1-day adult    0 carcass, 4-day adult    0 carcass, 20-day adult    0 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    0 accessory gland, mated 4-day male    0 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering    0 central nervous system, larvae L3    0 central nervous system, pupae P8    2 head, virgin 1-day female  (238) head, virgin 4-day female  (203) head, virgin 20-day female  (125) head, mated 1-day female  (195) head, mated 4-day female  (128) head, mated 20-day female  (110) head, mated 1-day male  (315) head, mated 4-day male  (202) head, mated 20-day male  (145) salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    0 digestive system, larvae L3 wandering    0 digestive system, 1-day adult    0 digestive system, 4-day adult    0 digestive system, 20-day adult    0 fat body, larvae L3 wandering    0 fat body, white prepupae    0 fat body, pupae P8    3 carcass, larvae L3 wandering    1 carcass, 1-day adult    0 carcass, 4-day adult    0 carcass, 20-day adult    0 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    0 accessory gland, mated 4-day male    0 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    0 central nervous system, larvae L3    0 central nervous system, pupae P8    2 head, virgin 1-day female  (238) head, virgin 4-day female  (203) head, virgin 20-day female  125 head, mated 1-day female  (195) head, mated 4-day female  128 head, mated 20-day female  110 head, mated 1-day male  (315) head, mated 4-day male  (202) head, mated 20-day male  (145) salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    0 digestive system, larvae L3 wandering    0 digestive system, 1-day adult    0 digestive system, 4-day adult    0 digestive system, 20-day adult    0 fat body, larvae L3 wandering    0 fat body, white prepupae    0 fat body, pupae P8    3 carcass, larvae L3 wandering    1 carcass, 1-day adult    0 carcass, 4-day adult    0 carcass, 20-day adult    0 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    0 accessory gland, mated 4-day male    0 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    0 central nervous system, larvae L3    0 central nervous system, pupae P8    2 head, virgin 1-day female    238 head, virgin 4-day female    203 head, virgin 20-day female    125 head, mated 1-day female    195 head, mated 4-day female    128 head, mated 20-day female    110 head, mated 1-day male    315 head, mated 4-day male    202 head, mated 20-day male    145 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    0 digestive system, larvae L3 wandering    0 digestive system, 1-day adult    0 digestive system, 4-day adult    0 digestive system, 20-day adult    0 fat body, larvae L3 wandering    0 fat body, white prepupae    0 fat body, pupae P8    3 carcass, larvae L3 wandering    1 carcass, 1-day adult    0 carcass, 4-day adult    0 carcass, 20-day adult    0 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    0 accessory gland, mated 4-day male    0 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Tissue   Expression Level imaginal disc, larvae L3 wandering     central nervous system, larvae L3     central nervous system, pupae P8     head, virgin 1-day female     head, virgin 4-day female     head, virgin 20-day female     head, mated 1-day female     head, mated 4-day female     head, mated 20-day female     head, mated 1-day male     head, mated 4-day male     head, mated 20-day male     salivary gland, larvae L3 wandering     salivary gland, white prepupae     digestive system, larvae L3 wandering     digestive system, 1-day adult     digestive system, 4-day adult     digestive system, 20-day adult     fat body, larvae L3 wandering     fat body, white prepupae     fat body, pupae P8     carcass, larvae L3 wandering     carcass, 1-day adult     carcass, 4-day adult     carcass, 20-day adult     ovary, virgin 4-day female     ovary, mated 4-day female     testis, mated 4-day male     accessory gland, mated 4-day male
modENCODE Development RNA-Seq
modENCODE Temporal Expression Data (modENCODE_mRNA-Seq_U)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    0 embryo 04-06hr    0 embryo 06-08hr    0 embryo 08-10hr    0 embryo 10-12hr    0 embryo 12-14hr    0 embryo 14-16hr    0 embryo 16-18hr    0 embryo 18-20hr    0 embryo 20-22hr    0 embryo 22-24hr    0 larva L1    0 larva L2    0 larva L3 12hr old    0 larva L3 puffstage 1-2    0 larva L3 puffstage 3-6    0 larva L3 puffstage 7-9    0 white prepupae new    0 white prepupae 12hr    0 white prepupae 24hr    0 pupae 2d postWPP    2 pupae 3d postWPP    17 pupae 4d postWPP    104 adult male 01day    55 adult male 05day    22 adult male 30day    21 adult female 01day    34 adult female 05day    4 adult female 30day    4 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    0 embryo 04-06hr    0 embryo 06-08hr    0 embryo 08-10hr    0 embryo 10-12hr    0 embryo 12-14hr    0 embryo 14-16hr    0 embryo 16-18hr    0 embryo 18-20hr    0 embryo 20-22hr    0 embryo 22-24hr    0 larva L1    0 larva L2    0 larva L3 12hr old    0 larva L3 puffstage 1-2    0 larva L3 puffstage 3-6    0 larva L3 puffstage 7-9    0 white prepupae new    0 white prepupae 12hr    0 white prepupae 24hr    0 pupae 2d postWPP    2 pupae 3d postWPP    17 pupae 4d postWPP  (104) adult male 01day  (55) adult male 05day    22 adult male 30day    21 adult female 01day  (34) adult female 05day    4 adult female 30day    4 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    0 embryo 04-06hr    0 embryo 06-08hr    0 embryo 08-10hr    0 embryo 10-12hr    0 embryo 12-14hr    0 embryo 14-16hr    0 embryo 16-18hr    0 embryo 18-20hr    0 embryo 20-22hr    0 embryo 22-24hr    0 larva L1    0 larva L2    0 larva L3 12hr old    0 larva L3 puffstage 1-2    0 larva L3 puffstage 3-6    0 larva L3 puffstage 7-9    0 white prepupae new    0 white prepupae 12hr    0 white prepupae 24hr    0 pupae 2d postWPP    2 pupae 3d postWPP    17 pupae 4d postWPP  104 adult male 01day    55 adult male 05day    22 adult male 30day    21 adult female 01day    34 adult female 05day    4 adult female 30day    4 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    0 embryo 04-06hr    0 embryo 06-08hr    0 embryo 08-10hr    0 embryo 10-12hr    0 embryo 12-14hr    0 embryo 14-16hr    0 embryo 16-18hr    0 embryo 18-20hr    0 embryo 20-22hr    0 embryo 22-24hr    0 larva L1    0 larva L2    0 larva L3 12hr old    0 larva L3 puffstage 1-2    0 larva L3 puffstage 3-6    0 larva L3 puffstage 7-9    0 white prepupae new    0 white prepupae 12hr    0 white prepupae 24hr    0 pupae 2d postWPP    2 pupae 3d postWPP    17 pupae 4d postWPP    104 adult male 01day    55 adult male 05day    22 adult male 30day    21 adult female 01day    34 adult female 05day    4 adult female 30day    4 Expression Level Scale  Extremely high  log, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    0 embryo 04-06hr    0 embryo 06-08hr    0 embryo 08-10hr    0 embryo 10-12hr    0 embryo 12-14hr    0 embryo 14-16hr    0 embryo 16-18hr    0 embryo 18-20hr    0 embryo 20-22hr    0 embryo 22-24hr    0 larva L1    0 larva L2    0 larva L3 12hr old    0 larva L3 puffstage 1-2    0 larva L3 puffstage 3-6    0 larva L3 puffstage 7-9    0 white prepupae new    0 white prepupae 12hr    0 white prepupae 24hr    0 pupae 2d postWPP    2 pupae 3d postWPP    17 pupae 4d postWPP    104 adult male 01day    55 adult male 05day    22 adult male 30day    21 adult female 01day    34 adult female 05day    4 adult female 30day    4 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    0 embryo 04-06hr    0 embryo 06-08hr    0 embryo 08-10hr    0 embryo 10-12hr    0 embryo 12-14hr    0 embryo 14-16hr    0 embryo 16-18hr    0 embryo 18-20hr    0 embryo 20-22hr    0 embryo 22-24hr    0 larva L1    0 larva L2    0 larva L3 12hr old    0 larva L3 puffstage 1-2    0 larva L3 puffstage 3-6    0 larva L3 puffstage 7-9    0 white prepupae new    0 white prepupae 12hr    0 white prepupae 24hr    0 pupae 2d postWPP    2 pupae 3d postWPP    17 pupae 4d postWPP  (104) adult male 01day  (55) adult male 05day    22 adult male 30day    21 adult female 01day  (34) adult female 05day    4 adult female 30day    4 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    0 embryo 04-06hr    0 embryo 06-08hr    0 embryo 08-10hr    0 embryo 10-12hr    0 embryo 12-14hr    0 embryo 14-16hr    0 embryo 16-18hr    0 embryo 18-20hr    0 embryo 20-22hr    0 embryo 22-24hr    0 larva L1    0 larva L2    0 larva L3 12hr old    0 larva L3 puffstage 1-2    0 larva L3 puffstage 3-6    0 larva L3 puffstage 7-9    0 white prepupae new    0 white prepupae 12hr    0 white prepupae 24hr    0 pupae 2d postWPP    2 pupae 3d postWPP    17 pupae 4d postWPP  104 adult male 01day    55 adult male 05day    22 adult male 30day    21 adult female 01day    34 adult female 05day    4 adult female 30day    4 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    0 embryo 04-06hr    0 embryo 06-08hr    0 embryo 08-10hr    0 embryo 10-12hr    0 embryo 12-14hr    0 embryo 14-16hr    0 embryo 16-18hr    0 embryo 18-20hr    0 embryo 20-22hr    0 embryo 22-24hr    0 larva L1    0 larva L2    0 larva L3 12hr old    0 larva L3 puffstage 1-2    0 larva L3 puffstage 3-6    0 larva L3 puffstage 7-9    0 white prepupae new    0 white prepupae 12hr    0 white prepupae 24hr    0 pupae 2d postWPP    2 pupae 3d postWPP    17 pupae 4d postWPP    104 adult male 01day    55 adult male 05day    22 adult male 30day    21 adult female 01day    34 adult female 05day    4 adult female 30day    4 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     modENCODE Temporal Expression Data (Graveley et al., 2011)
modENCODE Cell Lines RNA-Seq
modENCODE Treatments RNA-Seq
modENCODE Treatment Expression Data (modENCODE_mRNA-Seq_treatments)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    11 cold shock, 4-day adult    7 heat shock, 4-day adult    6 Cadmium 50 mM 6 hrs, larvae L3    0 Cadmium 50 mM 12 hrs, larvae L3    0 Cadmium 50 mM 48 hrs, 4-day adult    5 Cadmium 100 mM 48 hrs, 4-day adult    19 Copper 0.5 mM 12 hrs, larvae L3    0 Copper 15 mM 48 hrs, 4-day adult    5 Zinc 5 mM 12 hrs, larvae L3    0 Zinc 4.5 mM 48 hrs, 4-day adult    16 Ethanol 2.5% 3 hrs, larvae L3    14 Ethanol 5% 3 hrs, larvae L3    0 Ethanol 10% 3 hrs, larvae L3    0 Caffeine 1.5 mg/ml 4 hrs, larvae L3    0 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    10 Caffeine 25 mg/ml 48 hrs, 4-day adult    6 Paraquat 5 mM 48 hrs, 4-day adult    20 Paraquat 10 mM 48 hrs, 4-day adult    20 Rotenone 2 μg 12 hrs, larvae L3    0 Rotenone 8 μg 12 hrs, larvae L3    0 Expression Level Scale  Very low   Low   Moderate  Linear, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult    11 cold shock, 4-day adult    7 heat shock, 4-day adult    6 Cadmium 50 mM 6 hrs, larvae L3    0 Cadmium 50 mM 12 hrs, larvae L3    0 Cadmium 50 mM 48 hrs, 4-day adult    5 Cadmium 100 mM 48 hrs, 4-day adult    19 Copper 0.5 mM 12 hrs, larvae L3    0 Copper 15 mM 48 hrs, 4-day adult    5 Zinc 5 mM 12 hrs, larvae L3    0 Zinc 4.5 mM 48 hrs, 4-day adult    16 Ethanol 2.5% 3 hrs, larvae L3    14 Ethanol 5% 3 hrs, larvae L3    0 Ethanol 10% 3 hrs, larvae L3    0 Caffeine 1.5 mg/ml 4 hrs, larvae L3    0 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    10 Caffeine 25 mg/ml 48 hrs, 4-day adult    6 Paraquat 5 mM 48 hrs, 4-day adult    20 Paraquat 10 mM 48 hrs, 4-day adult    20 Rotenone 2 μg 12 hrs, larvae L3    0 Rotenone 8 μg 12 hrs, larvae L3    0 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    11 cold shock, 4-day adult    7 heat shock, 4-day adult    6 Cadmium 50 mM 6 hrs, larvae L3    0 Cadmium 50 mM 12 hrs, larvae L3    0 Cadmium 50 mM 48 hrs, 4-day adult    5 Cadmium 100 mM 48 hrs, 4-day adult    19 Copper 0.5 mM 12 hrs, larvae L3    0 Copper 15 mM 48 hrs, 4-day adult    5 Zinc 5 mM 12 hrs, larvae L3    0 Zinc 4.5 mM 48 hrs, 4-day adult    16 Ethanol 2.5% 3 hrs, larvae L3    14 Ethanol 5% 3 hrs, larvae L3    0 Ethanol 10% 3 hrs, larvae L3    0 Caffeine 1.5 mg/ml 4 hrs, larvae L3    0 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    10 Caffeine 25 mg/ml 48 hrs, 4-day adult    6 Paraquat 5 mM 48 hrs, 4-day adult    20 Paraquat 10 mM 48 hrs, 4-day adult    20 Rotenone 2 μg 12 hrs, larvae L3    0 Rotenone 8 μg 12 hrs, larvae L3    0 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    11 cold shock, 4-day adult    7 heat shock, 4-day adult    6 Cadmium 50 mM 6 hrs, larvae L3    0 Cadmium 50 mM 12 hrs, larvae L3    0 Cadmium 50 mM 48 hrs, 4-day adult    5 Cadmium 100 mM 48 hrs, 4-day adult    19 Copper 0.5 mM 12 hrs, larvae L3    0 Copper 15 mM 48 hrs, 4-day adult    5 Zinc 5 mM 12 hrs, larvae L3    0 Zinc 4.5 mM 48 hrs, 4-day adult    16 Ethanol 2.5% 3 hrs, larvae L3    14 Ethanol 5% 3 hrs, larvae L3    0 Ethanol 10% 3 hrs, larvae L3    0 Caffeine 1.5 mg/ml 4 hrs, larvae L3    0 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    10 Caffeine 25 mg/ml 48 hrs, 4-day adult    6 Paraquat 5 mM 48 hrs, 4-day adult    20 Paraquat 10 mM 48 hrs, 4-day adult    20 Rotenone 2 μg 12 hrs, larvae L3    0 Rotenone 8 μg 12 hrs, larvae L3    0 Expression Level Scale  Extremely high  log, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    11 cold shock, 4-day adult    7 heat shock, 4-day adult    6 Cadmium 50 mM 6 hrs, larvae L3    0 Cadmium 50 mM 12 hrs, larvae L3    0 Cadmium 50 mM 48 hrs, 4-day adult    5 Cadmium 100 mM 48 hrs, 4-day adult    19 Copper 0.5 mM 12 hrs, larvae L3    0 Copper 15 mM 48 hrs, 4-day adult    5 Zinc 5 mM 12 hrs, larvae L3    0 Zinc 4.5 mM 48 hrs, 4-day adult    16 Ethanol 2.5% 3 hrs, larvae L3    14 Ethanol 5% 3 hrs, larvae L3    0 Ethanol 10% 3 hrs, larvae L3    0 Caffeine 1.5 mg/ml 4 hrs, larvae L3    0 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    10 Caffeine 25 mg/ml 48 hrs, 4-day adult    6 Paraquat 5 mM 48 hrs, 4-day adult    20 Paraquat 10 mM 48 hrs, 4-day adult    20 Rotenone 2 μg 12 hrs, larvae L3    0 Rotenone 8 μg 12 hrs, larvae L3    0 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult    11 cold shock, 4-day adult    7 heat shock, 4-day adult    6 Cadmium 50 mM 6 hrs, larvae L3    0 Cadmium 50 mM 12 hrs, larvae L3    0 Cadmium 50 mM 48 hrs, 4-day adult    5 Cadmium 100 mM 48 hrs, 4-day adult    19 Copper 0.5 mM 12 hrs, larvae L3    0 Copper 15 mM 48 hrs, 4-day adult    5 Zinc 5 mM 12 hrs, larvae L3    0 Zinc 4.5 mM 48 hrs, 4-day adult    16 Ethanol 2.5% 3 hrs, larvae L3    14 Ethanol 5% 3 hrs, larvae L3    0 Ethanol 10% 3 hrs, larvae L3    0 Caffeine 1.5 mg/ml 4 hrs, larvae L3    0 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    10 Caffeine 25 mg/ml 48 hrs, 4-day adult    6 Paraquat 5 mM 48 hrs, 4-day adult    20 Paraquat 10 mM 48 hrs, 4-day adult    20 Rotenone 2 μg 12 hrs, larvae L3    0 Rotenone 8 μg 12 hrs, larvae L3    0 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    11 cold shock, 4-day adult    7 heat shock, 4-day adult    6 Cadmium 50 mM 6 hrs, larvae L3    0 Cadmium 50 mM 12 hrs, larvae L3    0 Cadmium 50 mM 48 hrs, 4-day adult    5 Cadmium 100 mM 48 hrs, 4-day adult    19 Copper 0.5 mM 12 hrs, larvae L3    0 Copper 15 mM 48 hrs, 4-day adult    5 Zinc 5 mM 12 hrs, larvae L3    0 Zinc 4.5 mM 48 hrs, 4-day adult    16 Ethanol 2.5% 3 hrs, larvae L3    14 Ethanol 5% 3 hrs, larvae L3    0 Ethanol 10% 3 hrs, larvae L3    0 Caffeine 1.5 mg/ml 4 hrs, larvae L3    0 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    10 Caffeine 25 mg/ml 48 hrs, 4-day adult    6 Paraquat 5 mM 48 hrs, 4-day adult    20 Paraquat 10 mM 48 hrs, 4-day adult    20 Rotenone 2 μg 12 hrs, larvae L3    0 Rotenone 8 μg 12 hrs, larvae L3    0 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    11 cold shock, 4-day adult    7 heat shock, 4-day adult    6 Cadmium 50 mM 6 hrs, larvae L3    0 Cadmium 50 mM 12 hrs, larvae L3    0 Cadmium 50 mM 48 hrs, 4-day adult    5 Cadmium 100 mM 48 hrs, 4-day adult    19 Copper 0.5 mM 12 hrs, larvae L3    0 Copper 15 mM 48 hrs, 4-day adult    5 Zinc 5 mM 12 hrs, larvae L3    0 Zinc 4.5 mM 48 hrs, 4-day adult    16 Ethanol 2.5% 3 hrs, larvae L3    14 Ethanol 5% 3 hrs, larvae L3    0 Ethanol 10% 3 hrs, larvae L3    0 Caffeine 1.5 mg/ml 4 hrs, larvae L3    0 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    10 Caffeine 25 mg/ml 48 hrs, 4-day adult    6 Paraquat 5 mM 48 hrs, 4-day adult    20 Paraquat 10 mM 48 hrs, 4-day adult    20 Rotenone 2 μg 12 hrs, larvae L3    0 Rotenone 8 μg 12 hrs, larvae L3    0 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Treatment   Expression Level extended cold, 4-day adult     cold shock, 4-day adult     heat shock, 4-day adult     Cadmium 50 mM 6 hrs, larvae L3     Cadmium 50 mM 12 hrs, larvae L3     Cadmium 50 mM 48 hrs, 4-day adult     Cadmium 100 mM 48 hrs, 4-day adult     Copper 0.5 mM 12 hrs, larvae L3     Copper 15 mM 48 hrs, 4-day adult     Zinc 5 mM 12 hrs, larvae L3     Zinc 4.5 mM 48 hrs, 4-day adult     Ethanol 2.5% 3 hrs, larvae L3     Ethanol 5% 3 hrs, larvae L3     Ethanol 10% 3 hrs, larvae L3     Caffeine 1.5 mg/ml 4 hrs, larvae L3     Caffeine 2.5 mg/ml 48 hrs, 4-day adult     Caffeine 25 mg/ml 48 hrs, 4-day adult     Paraquat 5 mM 48 hrs, 4-day adult     Paraquat 10 mM 48 hrs, 4-day adult     Rotenone 2 μg 12 hrs, larvae L3     Rotenone 8 μg 12 hrs, larvae L3
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (Graveley et al., 2011) mE1_20_mRNA_expression_cluster_20
External Data & Images
Linkouts
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele viable, with Scer\GAL4pnr-MD237 CpnGD5175 Other Phenotypes Allele neuroanatomy defective | adult stage | progressive, with Scer\GAL4GMR.PU CpndsRNA.Scer\UAS.WIZ neurophysiology defective | adult stage, with Scer\GAL4GMR.PU CpndsRNA.Scer\UAS.WIZ visible, with Scer\GAL4pnr-MD237 CpnGD5175 visible | semidominant Cpn36 Cpn65 Cpn85 Cpn97 wild-type Cpn+t8 Phenotype manifest in Allele photoreceptor cell | P-stage Cpn36 Cpn97 Cpn85 Cpn65 photoreceptor cell pigment granule, with Scer\GAL4GMR.PU CpndsRNA.Scer\UAS.WIZ rhabdomere | progressive, with Scer\GAL4GMR.PU CpndsRNA.Scer\UAS.WIZ rhabdomere | P-stage Cpn58 Cpn51 Cpn107 Cpn68 Cpn115 trichogen cell, with Scer\GAL4pnr-MD237 CpnGD5175
Classical Alleles ( 9 )
For All Classical Alleles Show
Allele of Cpn Class Mutagen Stocks Known lesion Cpn107 hypomorphic allele - genetic evidence gamma ray 0 -- Cpn115 hypomorphic allele - genetic evidence gamma ray 0 -- Cpn36 antimorphic allele - genetic evidence gamma ray 0 -- Cpn51 hypomorphic allele - genetic evidence gamma ray 0 -- Cpn58 hypomorphic allele - genetic evidence gamma ray 0 -- Cpn65 antimorphic allele - genetic evidence gamma ray 0 -- Cpn68 hypomorphic allele - genetic evidence gamma ray 0 -- Cpn85 antimorphic allele - genetic evidence gamma ray 0 -- Cpn97 antimorphic allele - genetic evidence gamma ray 0 --
Alleles Carried on Transgenic Constructs ( 7 )
For All Alleles Carried on Transgenic Constructs Show
Allele of Cpn Class Mutagen Stocks Known lesion CpnninaE.T:Zzzz\His6 in vitro construct - regulatory fusion in vitro construct - coding region fusion 3 Yes CpnGD5175 in vitro construct - RNAi in vitro construct - regulatory fusion 2 Yes CpnJF02156 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes CpnKK110330 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes Cpn+t8 in vitro construct - genomic fragment 0 Yes CpndsRNA.Scer\UAS.WIZ in vitro construct - regulatory fusion in vitro construct - RNAi 0 Yes CpnninaE.T:Avic\GFP-EGFP in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes
Aneuploid Aberrations
Disrupted in	Df(3R)E229 (Yang and Ballinger, 1994) Df(3R)Exel6162 (Ryder, 2004.4.26) Df(3R)Exel7313 (Ryder, 2004.4.26) Df(3R)kar-D1 (Yang and Ballinger, 1994) Df(3R)kar-Sz12 (Yang and Ballinger, 1994) Df(3R)P-29 (Yang and Ballinger, 1994) Df(3R)T-47 (Ballinger et al., 1993)
Not disrupted in	Df(3R)T-47 (Yang and Ballinger, 1994)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD5175} NA P{KK110330} NA P{TRiP.JF02156} NA P{UAS-Cpn.RNAi} NA characterization construct P{ninaE-Cpn.GFP} NA P{ninaE-His.Cpn} NA P{W8-Xcap} NA
Insertions
	Type of insertions Name Expression data
Gene Ontology: Function, Process & Cellular Component ( 10 unique terms )
Terms Based on Experimental Evidence ( 10 terms )
Molecular Function
CV term Evidence References
calcium ion binding inferred from direct assay (Martin et al., 1993, Ballinger et al., 1993)
Biological Process
CV term Evidence References
rhabdomere development inferred from mutant phenotype (Yang and Ballinger, 1994) sequestering of calcium ion inferred from direct assay (Weiss et al., 2012) inferred from mutant phenotype (Weiss et al., 2012)
Cellular Component
CV term Evidence References
axon inferred from direct assay (Ballinger et al., 1993, Martin et al., 1993) cell body inferred from direct assay (Ballinger et al., 1993) cytoplasm inferred from direct assay (Weiss et al., 2012, Martin et al., 1993) NOT mitochondrion inferred from direct assay (Martin et al., 1993) NOT nucleus inferred from direct assay (Martin et al., 1993) NOT rhabdomere inferred from direct assay (Martin et al., 1993) NOT rough endoplasmic reticulum inferred from direct assay (Martin et al., 1993)
Terms Based on Predictions or Assertions ( 1 term )
Molecular Function ( 0 terms)
Biological Process
CV term Evidence References
sequestering of calcium ion inferred by curator from GO:0005509 (Martin et al., 1993)
Cellular Component ( 0 terms)
Sequence Ontology: Class of Gene
	gene   gene_with_edited_transcript (Stapleton et al., 2006, Graveley et al., 2011) nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions Cpn allele Gene References
External Data
Linkouts	DroID - A comprehensive database of gene and protein interactions. • FBgn0261714 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 41474
Orthologs
OrthoDB Orthologs (23) - based on analysis using Dmel annotation version 5.41
OrthoDB Ortholog Groups
	OrthoDB orthology group searches (Waterhouse et al., 2011, Nucleic Acids Res. 39(Database issue): D283--D288) Drosophila inclusive ortholog search EOG6GTKZP Dipteran inclusive ortholog search EOG6MKNQQ Insect inclusive ortholog search EOG67PW3F Arthropod inclusive ortholog search EOG61ZCTD Metazoa inclusive ortholog search No orthologs identified
Orthologs in Drosophila Species (EOG6GTKZP)
Organism Common Name Gene AAA Syntenic Ortholog Multiple Dmel Genes in this Orthologous Group Drosophila melanogaster fruit fly  Dmel\Cpn     Drosophila melanogaster fruit fly  Dmel\toc     Drosophila simulans   Dsim\GD22780   Y Drosophila sechellia   Dsec\GM18169   Y Drosophila erecta   Dere\GG24460   Y Drosophila yakuba   Dyak\GE14943   Y Drosophila ananassae   Dana\GF20582   Y Drosophila pseudoobscura pseudoobscura   Dpse\GA25463   Y Drosophila persimilis   Dper\GL25837   Y Drosophila willistoni   Dwil\GK15039   Y Drosophila virilis   Dvir\GJ19558   Y Drosophila virilis   Dvir\GJ11344   Y Drosophila mojavensis   Dmoj\GI17983   Y Drosophila mojavensis   Dmoj\GI17699   Y Drosophila grimshawi   Dgri\GH10288   Y
Orthologs in non-Drosophila Dipterans (EOG6MKNQQ)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Aedes aegypti Yellow fever mosquito  Aaeg\AAEL011678 Y Aedes aegypti Yellow fever mosquito  Aaeg\AAEL005505 Y Anopheles gambiae Malaria mosquito  Agam\AGAP008556 Y Culex quinquefasciatus Southern house mosquito  Cqui\CPIJ000422 Y
Orthologs in non-Dipteran Insects (EOG67PW3F)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Bombyx mori Silkmoth  Bmor\BGIBMGA010581 Y Pediculus humanus Human body louse  Phum\PHUM154330 Y Tribolium castaneum Red flour beetle  Tcas\TC012431 Y
Orthologs in non-Insect Arthropods (EOG61ZCTD)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Daphnia pulex Water flea  Dpux\FIGLA Y
Orthologs in non-Arthropod Metazoa (None identified)
No non-Arthropod Metazoa orthologies identified
Human Orthologs (0)
Gene OMIM HGNC
AAA Orthologs (9) based on analysis using Dmel annotation version 4.3
Organism Gene Drosophila simulans Dsim\GD20599 Drosophila sechellia Dsec\GM26038 Drosophila erecta Dere\GG17156 Drosophila yakuba Dyak\GE24546 Drosophila ananassae Dana\GF17743 Drosophila pseudoobscura pseudoobscura Dpse\GA26340 Drosophila willistoni Dwil\GK19196 Drosophila virilis Dvir\GJ10068 Drosophila grimshawi Dgri\GH15499
Stocks & Reagents
Stocks Listed in FlyBase ( 7 )
Bloomington	43332 P{ninaE-His.Cpn}1, y1 w* 31881 y1 v1; P{TRiP.JF02156}attP2 43330 y1 w*; P{ninaE-His.Cpn}5/SM6a 43331 y1 w*; P{ninaE-His.Cpn}3/TM3, Sb1
VDRC	v101962 P{KK110330}VIE-260B v13086 w1118; P{GD5175}v13086 v13422 w1118; P{GD5175}v13422
Genomic Clones ( 2 )
	BACR06O05 BACR30N15 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 63 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	GH08002
Other clones	FI03985
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	GH05334 GH07003 GH08209 GH09038 GH09480 GH11962 GH12977 GH14962 GH15413 GH17511 GH18059 GH20841 GH21620 GH22570 GH23076 GH24342 GH27542 GH28069 GH28575 HL01274 HL03676 HL06118 HL06171 RH06142 RH06183 RH07429 RH07893
Other clones	16517 16973 18500 32901 35394 37480 45764 63151 121802 156267 173402 176902 CK01.18A.F10 CK01.89D.G8 EC051251 EC051843 EC053351 EC054864 EC055840 EK020053 EK029903 EK125607 EK146023 EK155733 EK161827 EK189014 EK241913 EK259023 EK277629 EK281652 IP14809 IP15109 IP15624 IP15724
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0261714 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 41474
Antibody Information
	monoclonal (Ballinger et al., 1993)
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of
Source for database merge of
Additional comments
Other Comments
	Cpn is an immobile Ca[2+] buffer localised along the base of the rhabdomere, which is required to prevent light-induced retinal degeneration. (Weiss et al., 2012) Class I mutations of Cpn alter the structure of the rhabdomere, class II mutations have rough eyes due to misorientation of the rhabdomeres and photoreceptor cell death. These mutant phenotypes can be rescued by P-element mediated transformation of genomic Cpn DNA. Analysis of the mutants suggests the Cpn plays important roles in both rhadomere development and photoreceptor cell survival. (Yang and Ballinger, 1994) Class I mutations of Cpn alter the structure of the rhabdomere, class II mutations have rough eyes due to misorientation of the rhabdomeres and photoreceptor cell death. These mutant phenotypes can be rescued by P-element mediated transformation of genomic Cpn DNA. (Yang and Ballinger, 1994) The Cpn protein binds calcium, contains a long C-terminal leucine zipper and is expressed in the soma and axons of all photoreceptor cells, early in development, when cell-type decisions are being made. Cpn expression pattern is unaffected by mutations in the gl gene, which block photoreceptor development. (Ballinger et al., 1993) Monoclonal antibody 72H5 was used to isolate this protein, which is the same protein as isolated by Martin et al, PNAS 90: 1531--1535, isolated using a different monoclonal antibody, 23E9. (Ballinger et al., 1993) Monoclonal antibody 23E9 used to identify Cpn calcium binding protein in photoreceptor cells and ocelli: the location of the protein within a distinct cytoplasmic region suggests that it might function as a calcium sequestering "sponge" regulating the amount of free cytoplasmic calcium. (Martin et al., 1993)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_169454 NM_169455 RefSeq (Proteins) • NP_731673 NP_731674 DDBJ / EMBL / GenBank • AAA28405 AAA28420 AAF54754 AAF54755 AAL13544 AI108764 AW940288 AY058315 L02111 L05080 Entrez Gene - A searchable database of RefSeq genes. • 41474 UniProtKB/Swiss-Prot • Q02910
Other Crossreferences
Linkouts
	DroID - A comprehensive database of gene and protein interactions. • FBgn0261714 DRSC - Results from RNAi screens. • FBgn0261714 FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0261714 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 41474 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 41474 modMine - Data generated by the modENCODE project. • FBgn0261714
Synonyms & Secondary IDs ( 12 )
Reported As
Symbol Synonym	77H5 (Ballinger and Benzer, 1989) Ag 72H5 (Ballinger, 1991) Ag72H5   cap (Yang and Ballinger, 1994, Ballinger et al., 1993) CG4795 (Keleman et al., 2009.8.5, Perkins et al., 2009) Cpn (Weiss et al., 2012, Bao and Friedrich, 2009, Stapleton et al., 2006, Geng and MacDonald, 2007, Ranade et al., 2008, Fernández-Ayala et al., 2010, Weiss and Minke, 2013.1.25) cpn (Yang et al., 2005, Goldman and Arbeitman, 2007) Mab77H5
Name Synonym	calcium-binding protein (Martin, 1992) Calphotin (Bao and Friedrich, 2009, Goldman and Arbeitman, 2007) calphotin (Ballinger, 1993.5.7, Goldman and Arbeitman, 2007) Monoclonal antibody 77H5
Secondary FlyBase IDs
	FBgn0002637 FBgn0004451 FBgn0010218
References ( 35 )
Generate a list of	All references relating to this gene ( 35 )
List References by type	Research paper  ( 14 ) Supplementary material  ( 4 ) Personal communication to FlyBase  ( 7 ) Abstract  ( 3 ) FlyBase analysis  ( 2 ) DNA/RNA sequence record  ( 2 ) Curated genome annotation  ( 2 )
Recent research papers ( 1 )
	Weiss et al., 2012, J. Neurosci. 32(42): 14696--14708 Compartmentalization and Ca2+ Buffering Are Essential for Prevention of Light-Induced Retinal Degeneration. [FBrf0219751] Show all research papers ...