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Gene Dmel\Dbx

General Information
Symbol	Dmel\Dbx	Species	D. melanogaster
Name	Dbx	Annotation symbol	CG42234
Feature type	protein_coding_gene	FlyBase ID	FBgn0261723
Gene Model Status	Current	Stock availability	6 publicly available
Genomic Location
Chromosome (arm)	3L	Recombination map
Cytogenetic map	62B10-62B11	Sequence location	3L:1,921,307..1,933,448 [+]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents modENCODE GBrowse	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene Dbx is referred to in FlyBase by the symbol Dmel\Dbx (CG42234, FBgn0261723). It is a protein_coding_gene from Drosophila melanogaster. Based on sequence similarity, it is predicted to have molecular function: sequence-specific DNA binding transcription factor activity. There is experimental evidence that it is involved in the biological process: axon guidance; neuron fate commitment; nervous system development. 9 alleles are reported. The phenotypes of these alleles are annotated with: tract; SNc; intersegmental nerve; longitudinal connective; ISNb. It has one annotated transcript and one annotated polypeptide. Protein features are: Helix-turn-helix motif, lambda-like repressor; Homeobox; Homeobox, conserved site; Homeodomain-like; Homeodomain-related. Gene sequence location is 3L:1921307..1933448.
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
Update Feed	Click the icon below to subscribe to this FlyBase record and receive updates automatically through your feed reader.
FB2012_01	Sequence features BKN28137 HFA08270 HFA08271 HFA08394 BKN30526
FB2011_10
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 62B10-62B11   Limits computationally determined from genome sequence between P{PZ}dlt04276 and P{PZ}slsrL182
Experimentally Determined Cytological Location
Cytogenetic map Notes References
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\Dbx for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
	Gene merge based on EST/cDNA data
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) Dbx-RC FBtr0290136  NM_139420   2334   741
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein Dbx-PC   FBpp0288576   81.2   741   7.00     NP_647677   AAF47594
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Homeobox, conserved site (IPR017970) Homeodomain-related (IPR012287) Homeodomain-like (IPR009057) Homeobox (IPR001356) Helix-turn-helix motif, lambda-like repressor (IPR000047)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AE014296 AAF47594   CK661628   EY198911
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL	Q9W064
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
Polypeptide Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
High-Throughput Expression Data
or
See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes. modENCODE Temporal Expression Data (Graveley et al., 2011) FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
Expression Clusters
External Data & Images
Linkouts
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele viable DbxΔ48 viable, with Scer\GAL4pnr-MD237 DbxGD4315 Sterility Allele fertile DbxΔ48 Other Phenotypes Allele flightless DbxΔ48 locomotor behavior defective DbxΔ48 neuroanatomy defective, with Scer\GAL4elav-C155 DbxScer\UAS.fl Phenotype manifest in Allele intersegmental nerve, with Scer\GAL4elav-C155 DbxScer\UAS.fl ISNb, with Scer\GAL4elav-C155 DbxScer\UAS.fl longitudinal connective, with Scer\GAL4elav-C155 DbxScer\UAS.fl SNc, with Scer\GAL4elav-C155 DbxScer\UAS.fl tract, with Scer\GAL4elav-C155 DbxScer\UAS.fl
Classical Alleles ( 3 )
For All Classical Alleles Show
Allele of Dbx Class Mutagen Stocks Known lesion DbxKG00100 1 Yes DbxMB10238 1 -- DbxΔ48 P-element activity 0 Yes
Alleles Carried on Transgenic Constructs ( 6 )
For All Alleles Carried on Transgenic Constructs Show
Allele of Dbx Class Mutagen Stocks Known lesion DbxGD4315 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes DbxJF02193 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes DbxKK108137 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes DbxKK110526 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes DbxGD8170 in vitro construct - RNAi in vitro construct - regulatory fusion 0 Yes DbxScer\UAS.fl in vitro construct - regulatory fusion 0 Yes
Aneuploid Aberrations
Disrupted in	Df(3L)R-G7 (Lacin et al., 2009)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{TRiP.JF02193} NA P{UAS-dbx.fl} NA
Insertions
	Type of insertions Name Expression data miscellaneous insertions P{SUPor-P}DbxKG00100 NA insertion of enhancer trap binary system Mi{ET1}DbxMB10238 No
Gene Ontology: Function, Process & Cellular Component ( 7 unique terms )
Terms Based on Experimental Evidence ( 3 terms )
Molecular Function ( 0 terms)
Biological Process
CV term Evidence References
axon guidance inferred from mutant phenotype (Lacin et al., 2009) nervous system development inferred from mutant phenotype (Broihier et al., 2002) neuron fate commitment inferred from mutant phenotype (Lacin et al., 2009)
Cellular Component ( 0 terms)
Terms Based on Predictions or Assertions ( 4 terms )
Molecular Function
CV term Evidence References
sequence-specific DNA binding transcription factor activity inferred from sequence or structural similarity with InterPro:IPR001356 (FlyBase, 1992-) transcription regulatory region sequence-specific DNA binding inferred from electronic annotation with InterPro:IPR000047 (FlyBase Curators et al., 2004-)
Biological Process
CV term Evidence References
regulation of transcription, DNA-dependent inferred from sequence or structural similarity with InterPro:IPR001356 (FlyBase, 1992-)
Cellular Component
CV term Evidence References
nucleus inferred from sequence or structural similarity with InterPro:IPR001356 (FlyBase, 1992-)
Sequence Ontology: Class of Gene
	gene   nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Protein-protein
Interacting group Assay References
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions Dbx allele Gene References
External Data
Linkouts	DroID - A comprehensive database of gene and protein interactions. • FBgn0261723 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 38254
Orthologs
Genome-wide drosophilid orthologs	Dana\GF20095 Dana\GF24846 Dere\GG14835 Dere\GG14836 Dgri\GH16165 Dgri\GH16166 Dmoj\GI13318 Dmoj\GI13319 Dper\GL25317 Dpse\GA11582 Dpse\GA25523 Dsec\GM14458 Dsec\GM14459 Dsim\GD13657 Dvir\GJ12088 Dvir\GJ12089 Dwil\GK12527 Dwil\GK12528 Dyak\GE21200 Dyak\GE21201
Curated drosophilid orthologs	Dpse\GA11582   Dpse\GA12630
Linkouts	OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • LH22527 ISCW020093 FBgn0238476 FBgn0214538 FBgn0199341 FBgn0169382 JGI_V11_37379 FBgn0071633 FBgn0162901 FBgn0136076 FBgn0123637 FBgn0107091 FBgn0097102 CPIJ016099 BGIBMGA011355 AGAP005727 AAEL005974 PB21561 PHUM365830 GLEAN_15146
Stocks & Reagents
Stocks Listed in FlyBase ( 6 )
Bloomington	29104 w1118; Mi{ET1}DbxMB10238 31904 y1 v1; P{TRiP.JF02193}attP2 13038 y1 w67c23; ry506 P{SUPor-P}DbxKG00100
VDRC	v102396 P{KK110526}VIE-260B v104389 P{KK108137}VIE-260B v10513 w1118; P{GD4315}v10513
Genomic Clones ( 1 )
	BACR16A03 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 1 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones
Other clones
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	LP21251
Other clones
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0261723 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 38253 38254
Antibody Information
	polyclonal (Lacin et al., 2009)
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of
Source for database merge of	Source for merge of: CG13925 CG12361 (FlyBase Genome Annotators, 2008) Source for merge of: Dbx CG42234 (Lacin et al., 2009)
Additional comments	Annotations CG13925 and CG12361 merged as CG42234 in release 5.6 of the genome annotation. (FlyBase Genome Annotators, 2008)
Other Comments
	Misexpression of Dbx severely disrupts neuronal fates. (Broihier et al., 2002) Identification: Comparative genomic approach to identify and screen potential regulators of eve and exex. (Broihier et al., 2002)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_139420 RefSeq (Proteins) • NP_647677 DDBJ / EMBL / GenBank • AAF47594 Entrez Gene - A searchable database of RefSeq genes. • 38254 UniProtKB/TrEMBL • Q9W064
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Homeobox, conserved site (IPR017970) Homeodomain-related (IPR012287) Homeodomain-like (IPR009057) Homeobox (IPR001356) Helix-turn-helix motif, lambda-like repressor (IPR000047)
Linkouts
	DroID - A comprehensive database of gene and protein interactions. • FBgn0261723 DRSC - Results from RNAi screens. • FBgn0261723 FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0261723 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 38253 38254 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 38254 modMine - Data generated by the modENCODE project. • FBgn0261723 OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • LH22527 ISCW020093 FBgn0238476 FBgn0214538 FBgn0199341 FBgn0169382 JGI_V11_37379 FBgn0071633 FBgn0162901 FBgn0136076 FBgn0123637 FBgn0107091 FBgn0097102 CPIJ016099 BGIBMGA011355 AGAP005727 AAEL005974 PB21561 PHUM365830 GLEAN_15146
Synonyms & Secondary IDs ( 6 )
Reported As
Symbol Synonym	CG12361   CG13925   CG42234 (FlyBase Genome Annotators, 2008, Keleman et al., 2009.8.5, Perkins et al., 2009) dbx (Lacin et al., 2009, Lacin et al., 2008) Dbx (Lacin et al., 2007) dDbx (Broihier et al., 2002)
Name Synonym	CG12361   CG13925   Dbx
Secondary FlyBase IDs
	FBgn0035291 FBgn0035292 FBgn0062390 FBgn0250756
References ( 18 )
Research paper	Lacin et al., 2009, Development 136(19): 3257--3266 dbx mediates neuronal specification and differentiation through cross-repressive, lineage-specific interactions with eve and hb9. [FBrf0210354]
Supplementary material	Mummery-Widmer et al., 2009, Nature 458(7241): Supplementary Table 2 - Genome-wide bristle screen results. [FBrf0214518] Dietzl et al., 2007, Nature 448(7150): Supplementary Table 1. [FBrf0202579] Giot et al., 2003, Science 302(5651): Tables S1 to S7. [FBrf0166452]
Personal communication to FlyBase	Bellen, 2009.10.19, BDGP_2009_1020.GDP.xml BDGP_2009_1020.GDP.xml [FBrf0208884] Keleman et al., 2009.8.5, RNAi-phiC31 construct and insertion data submitted by the Vienna Drosophila RNAi Center RNAi-phiC31 construct and insertion data submitted by the Vienna Drosophila RNAi Center [FBrf0208510] Perkins et al., 2009, Update to TRiP stock collection. Update to TRiP stock collection. [FBrf0208864] Dickson et al., 2007.7.18, RNAi construct and insertion data submitted by the Vienna Drosophila RNAi Center RNAi construct and insertion data submitted by the Vienna Drosophila RNAi Center [FBrf0200327] FlyBase Curators et al., 2004-, Gene Ontology annotation in FlyBase through association of InterPro records with GO terms. Gene Ontology annotation in FlyBase through association of InterPro records with GO terms. [FBrf0174215]
Abstract	Lacin et al., 2008, A. Dros. Res. Conf. 49: 581B Dbx represses Eve in the ventral nerve cord of Drosophila embryos. [FBrf0204087] Lacin et al., 2007, A. Dros. Res. Conf. 48: 586A Charecterizing the role of Dbx in the embryonic CNS development. [FBrf0198061] Broihier et al., 2002, A. Dros. Res. Conf. 43: 716B Coordinate regulation of neuronal fate by homeodomain factors Exex, dNkx6, and dDbx. [FBrf0146337]
FlyBase analysis	FlyBase Genome Annotators, 2008, Changes affecting gene model number or type in release 5.6 of the annotated D.melanogaster genome. Changes affecting gene model number or type in release 5.6 of the annotated D.melanogaster genome. [FBrf0202567] FlyBase, 1992-, FlyBase curation FlyBase curation. [FBrf0105495]
Computer file	Gene Disruption Project members, 2001-, [title not yet available] [title not yet available] [FBrf0132177] BDGP Project Members, 2000-, Berkeley Drosophila Genome Project. Berkeley Drosophila Genome Project. [FBrf0125078]
Automatic genome annotation	FamiliarityBreedsContempt, 1999.11, [Annotations performed at the Celera Jamboreee.] [Annotations performed at the Celera Jamboreee.] [FBrf0126705]
Curated genome annotation	Zhong, 1999.11, [Annotations performed at the Celera Jamboreee.] [Annotations performed at the Celera Jamboreee.] [FBrf0126703]