SP2523, Dank2, ESTS:149B10S
Gene model reviewed during 5.48
Gene model reviewed during 5.46
Low-frequency RNA-Seq exon junction(s) not annotated.
Annotated transcripts do not represent all possible combinations of alternative exons and/or alternative promoters.
Gene model reviewed during 5.53
May be component of a dicistronic gene; available data inconclusive.
Complex/atypical overlap: 3' coding exons overlap 3' UTR of nested gene.
None of the polypeptides share 100% sequence identity.
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Ank2 using the Feature Mapper tool.
Different Ank2 isoforms show different subcellular localizations. They are expressed in the embryonic central and peripheral nervous systems. Ank2 is found at neuromuscular junctions both between and within synaptic boutons. It is expressed in periactive zones in neruomuscular junctions.
Ank2 isoform Ank2-PL is expressed in the axon and presynaptic bouton at the neuromuscular junction. In the axon, expression of Ank2-PL is closely associated with the membrane and with the microtubule-associated protein futsch, and organised into a lattice-like structure. In the presynaptic boutons, Ank2-PL isoform is less abundant and found adjacent to the presynaptic active zone marker brp and in close proximity to the synaptic cell adhesion marker Fas2. In the areas between synaptic boutons, Ank2-PL protein is more abundant and organised into a lattice-like pattern.
GBrowse - Visual display of RNA-Seq signalsView Dmel\Ank2 in GBrowse 2
Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
Source for identity of: SP2523 CG7493
Annotations CG34416 and CG32377 merged as CG42734 (which corresponds to Ank2) in release 5.27 of the genome annotation.
Annotations CG7462, CG32375, CG34158 and CG34121 merged as CG34416 in release 5.2 of the genome annotation.
FlyBase curator comment: The symbol "CG18768" has been used erroneously in FlyBase to name 2 adjacent annotations in different releases of the genome annotation. The two annotations have been renamed in release 5.1 to avoid confusion; they are CG34158 (which corresponds to SP2523) and CG34121. CG34121 was labelled "CG18768" in release 2 of the genome annotation and was not annotated in releases 3.0 through 4.3, but has been reinstated (as CG34121) in release 5.1 of the genome annotation. CG34158 (which corresponds to SP2523) was labelled "CG7493" in release 2 of the genome annotation, was labelled "CG18768" in releases 3.0 through 4.3, and has been renamed CG34158 in release 5.1 of the genome annotation.
Source for identity of SP2523 CG7493 was sequence comparison ( date:000414 ).
dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R+ cell morphology.
New annotation (CG32375) in release 3 of the genome annotation.
New annotation (CG32377) in release 3 of the genome annotation.
Identification: as a protein that interacts with both Nrg isoforms in a yeast two-hybrid assay.
The existence of this gene is tentative, and is based on a match of an STS sequence from a European Drosophila Genome Mapping Project cosmid.