FlyBase Gene Report: Dmel\Ank2

General Information

Symbol

Dmel\Ank2

Species

D. melanogaster

Name

Ankyrin 2

Annotation Symbol

CG42734

Feature Type

protein_coding_gene

FlyBase ID

FBgn0261788

Gene Model Status

Stock Availability

17 publicly available

Gene Summary

Ankyrin 2 (Ank2) encodes a cytoskeletal binding protein required for proper function of the product of β-Spec via direct interaction. It contributes to the regulation of short-term memory, sound perception, microtubule cytoskeleton and neuromuscular junction development and synapsis. [Date last reviewed: 2019-03-07] (FlyBase Gene Snapshot)

All Summaries

Gene Snapshot
Alliance
Auto summary
Interactive Fly

Also Known As

SP2523, Dank2, ESTS:149B10S

Key Links

Genomic Location

Cytogenetic map

Sequence location

3L:7,655,389..7,718,395 [-]

Recombination map

3-21

RefSeq locus

NT_037436 REGION:7655389..7718395

Sequence

Get Decorated FASTA

Genomic Maps

JBrowse GBrowse

Other Genome Views

The following external sites may use different assemblies or annotations than FlyBase.

Function

GO Summary Ribbons

Gene Ontology (GO) Annotations (14 terms)

Molecular Function (0 terms)

Terms Based on Experimental Evidence (0 terms)

Terms Based on Predictions or Assertions (0 terms)

Biological Process (9 terms)

Terms Based on Experimental Evidence (8 terms)

CV Term

Evidence

References

involved_in axon extension

inferred from mutant phenotype

(Yamamoto et al., 2006)

involved_in microtubule cytoskeleton organization

inferred from mutant phenotype

(Koch et al., 2008, Pielage et al., 2008)

involved_in negative regulation of neuromuscular synaptic transmission

inferred from mutant phenotype

(Keller et al., 2011)

involved_in neuromuscular junction development

inferred from mutant phenotype

(Koch et al., 2008, Pielage et al., 2008)

involved_in neuron cellular homeostasis

inferred from genetic interaction with FLYBASE:Ank2; FB:FBgn0261788

(Keller et al., 2011)

involved_in positive regulation of synaptic assembly at neuromuscular junction

inferred from mutant phenotype

(Iqbal et al., 2013)

involved_in sensory perception of sound

inferred from mutant phenotype

(Senthilan et al., 2012)

involved_in short-term memory

inferred from mutant phenotype

(Iqbal et al., 2013)

Terms Based on Predictions or Assertions (1 term)

CV Term

Evidence

References

involved_in signal transduction

inferred from electronic annotation with InterPro:IPR000488

(assigned by InterPro )

(FlyBase Curators et al., 2004-)

Cellular Component (5 terms)

Terms Based on Experimental Evidence (5 terms)

CV Term

Evidence

References

located_in neuromuscular junction

inferred from direct assay

(Koch et al., 2008)

located_in plasma membrane

inferred from high throughput direct assay

(Tan et al., 2009)

located_in presynaptic membrane

inferred from direct assay

(Koch et al., 2008, Pielage et al., 2008)

located_in presynaptic periactive zone

inferred from direct assay

(Koch et al., 2008)

located_in terminal bouton

inferred from direct assay

(Pielage et al., 2008)

Terms Based on Predictions or Assertions (0 terms)

Gene Group (FlyBase)

Protein Family (UniProt)

-

Protein Signatures (InterPro)

Summaries

Gene Snapshot

Ankyrin 2 (Ank2) encodes a cytoskeletal binding protein required for proper function of the product of β-Spec via direct interaction. It contributes to the regulation of short-term memory, sound perception, microtubule cytoskeleton and neuromuscular junction development and synapsis. [Date last reviewed: 2019-03-07]

Summary (Interactive Fly)

Interactive Fly

Gene Model and Products

Number of Transcripts

20

Number of Unique Polypeptides

20

Please see the JBrowse view of Dmel\Ank2 for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)

Isoform displayed:

Pfam protein domains

InterPro name

classification

start

end

Protein Domains (via SMART)

Isoform displayed:

SMART protein domains

InterPro name

classification

start

end

Comments on Gene Model

Gene model reviewed during 5.48

Gene model reviewed during 5.46

Low-frequency RNA-Seq exon junction(s) not annotated.

Annotated transcripts do not represent all possible combinations of alternative exons and/or alternative promoters.

Gene model reviewed during 5.53

May be component of a dicistronic gene; available data inconclusive.

Complex/atypical overlap: 3' coding exons overlap 3' UTR of nested gene.

Sequence Ontology: Class of Gene

gene_with_edited_transcript

(Rodriguez et al., 2012, Graveley et al., 2011)

protein_coding_gene

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Assoc. CDS (aa)

FBtr0344224

38548

11634

FBtr0303120

2780

697

FBtr0303121

13793

4114

FBtr0303122

8886

2532

FBtr0303123

14018

4189

FBtr0303124

14309

4264

FBtr0303117

13700

4083

FBtr0303118

7820

2404

FBtr0303119

4752

1159

FBtr0303111

13764

4230

FBtr0303112

14130

4352

FBtr0303115

15005

4496

FBtr0303113

14438

4329

FBtr0303114

14120

4223

FBtr0303125

42128

13559

FBtr0334060

14636

4373

FBtr0334061

5268

1309

FBtr0334062

2261

547

FBtr0344222

8988

2566

FBtr0344223

14216

4233

Additional Transcript Data and Comments

Reported size (kB)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kDa)

Length (aa)

Theoretical pI

RefSeq ID

GenBank

FBpp0310630

1277.4

11634

4.80

FBpp0292239

75.7

697

7.85

FBpp0292240

452.5

4114

4.64

FBpp0292241

279.2

2532

5.69

FBpp0292242

460.7

4189

4.61

FBpp0292243

468.9

4264

4.83

FBpp0292236

448.9

4083

4.65

FBpp0292237

264.7

2404

6.12

FBpp0292238

125.8

1159

7.33

FBpp0292230

464.8

4230

4.63

FBpp0292231

478.7

4352

4.59

FBpp0292234

494.3

4496

4.74

FBpp0292232

475.7

4329

4.58

FBpp0292233

463.9

4223

4.62

FBpp0292244

1488.3

13559

4.65

FBpp0306185

480.4

4373

4.79

FBpp0306186

142.2

1309

7.50

FBpp0306187

59.3

547

7.74

FBpp0310628

282.5

2566

5.72

FBpp0310629

465.3

4233

4.83

Polypeptides with Identical Sequences

None of the polypeptides share 100% sequence identity.

Additional Polypeptide Data and Comments

Reported size (kDa)

Comments

External Data

Crossreferences

InterPro - A database of protein families, domains and functional sites

Linkouts

Sequences Consistent with the Gene Model

Nucleotide / Polypeptide Records

Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Ank2 using the Feature Mapper tool.

External Data

Crossreferences

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

Linkouts

Expression Data

Expression Summary Ribbons

Colored tiles in ribbon indicate that expression data has been curated by FlyBase for that anatomical location. Colorless tiles indicate that there is no curated data for that location.

For complete stage-specific expression data, view the modENCODE Development RNA-Seq section under High-Throughput Expression below.

Transcript Expression

expression microarray

Stage

Tissue/Position (including subcellular localization)

Reference

(Xu et al., 2004)

in situ

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage 11 -- 12

ventral nerve cord primordium

(Fisher et al., 2012, Bouley et al., 2000)

embryonic neuroblast of ventral nerve cord primordium

(Fisher et al., 2012)

midline primordium

(Fisher et al., 2012)

embryonic stage 13 -- 14

larval ventral nerve cord

(Bouley et al., 2000)

embryonic brain

(Bouley et al., 2000)

presumptive embryonic/larval peripheral nervous system

(Bouley et al., 2000)

embryonic stage 13 -- 16

embryonic brain

(Fisher et al., 2012)

embryonic/larval nervous system

(Fisher et al., 2012)

ventral midline of embryo

(Fisher et al., 2012)

larval ventral nerve cord

(Fisher et al., 2012)

northern blot

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage 15 -- 17

Comment: reference states 12-24 hr AEL

(Bouley et al., 2000)

(Bouley et al., 2000)

Additional Descriptive Data

Eye-enriched transcripts determined by ratio of expression level in wild-type heads. versus expression level in so heads.

(Xu et al., 2004)

Marker for

Subcellular Localization

CV Term

Polypeptide Expression

immunolocalization

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage 11 -- 12

ventral nerve cord primordium

(Bouley et al., 2000)

embryonic stage 12 -- 15

presumptive embryonic/larval central nervous system

(Koch et al., 2008)

presumptive embryonic/larval peripheral nervous system

(Koch et al., 2008)

embryonic stage 13

(Bouley et al., 2000)

embryonic stage 13 -- 15

neuron of presumptive embryonic/larval central nervous system

(Hortsch et al., 2002)

embryonic stage 13 -- 17

larval ventral nerve cord

(Bouley et al., 2000)

embryonic brain

(Bouley et al., 2000)

presumptive embryonic/larval peripheral nervous system

(Bouley et al., 2000)

embryonic/larval neuron

• neuronal cell body

(Bouley et al., 2000)

embryonic/larval neuron

• axon

(Bouley et al., 2000)

embryonic stage 14 -- 17

• axon

(Bouley et al., 2000)

embryonic stage 15

scolopidial neuron

(Hortsch et al., 2002)

embryonic stage 16 -- 17

embryonic/larval central nervous system

(Koch et al., 2008)

embryonic/larval peripheral nervous system

(Koch et al., 2008)

neuromuscular junction

(Koch et al., 2008)

• neuromuscular junction

(Koch et al., 2008)

(Koch et al., 2008)

• terminal bouton

(Koch et al., 2008)

embryonic stage 17

larval segmental nerve

• axon

(Bouley et al., 2000)

larval intersegmental nerve

• axon

(Bouley et al., 2000)

second instar larval stage

embryonic/larval neuromuscular junction

• axon

(Pielage et al., 2008)

embryonic/larval neuromuscular junction

• terminal bouton

(Pielage et al., 2008)

wandering third instar larval stage

embryonic/larval neuromuscular junction

• axon

(Pielage et al., 2008)

embryonic/larval neuromuscular junction

• terminal bouton

(Pielage et al., 2008)

photoreceptor cell

(Hortsch et al., 2002)

mass spectroscopy

Stage

Tissue/Position (including subcellular localization)

Reference

• membrane

(Aradska et al., 2015)

day 5 of adulthood & male -- day 7 of adulthood & male

(Wasbrough et al., 2010)

western blot

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage

• membrane

(Bouley et al., 2000)

Additional Descriptive Data

Different Ank2 isoforms show different subcellular localizations. They are expressed in the embryonic central and peripheral nervous systems. Ank2 is found at neuromuscular junctions both between and within synaptic boutons. It is expressed in periactive zones in neruomuscular junctions.

(Koch et al., 2008)

Ank2 isoform Ank2-PL is expressed in the axon and presynaptic bouton at the neuromuscular junction. In the axon, expression of Ank2-PL is closely associated with the membrane and with the microtubule-associated protein futsch, and organised into a lattice-like structure. In the presynaptic boutons, Ank2-PL isoform is less abundant and found adjacent to the presynaptic active zone marker brp and in close proximity to the synaptic cell adhesion marker Fas2. In the areas between synaptic boutons, Ank2-PL protein is more abundant and organised into a lattice-like pattern.

(Pielage et al., 2008)

The short isoform of Ank2 protein, i.e., Ank-PI, is localized to neuronal cell bodies, whereas antibodies to long isoforms stain primarily axonal pathways.

(Hortsch et al., 2002)

Marker for

Subcellular Localization

CV Term

Evidence

References

located_in neuromuscular junction

inferred from direct assay

(Koch et al., 2008)

located_in plasma membrane

inferred from high throughput direct assay

(Tan et al., 2009)

located_in presynaptic membrane

inferred from direct assay

(Koch et al., 2008, Pielage et al., 2008)

located_in presynaptic periactive zone

inferred from direct assay

(Koch et al., 2008)

located_in terminal bouton

inferred from direct assay

(Pielage et al., 2008)

Expression Deduced from Reporters

High-Throughput Expression Data

Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\Ank2 in GBrowse 2

RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region

View exonic expression by developmental stage for Dmel\Ank2

View exonic expression by tissue for Dmel\Ank2

Bulk Downloads

RNA-Seq RPKM values for all genes

Reference

See Gelbart and Emmert, 2013 for analysis details and data files for all genes.

Developmental Proteome: Life Cycle

Developmental Proteome: Embryogenesis

External Data and Images

Linkouts

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0261788

DRscDB

38863/tissue=All

EMBL-EBI Single Cell Expression Atlas

FBgn0261788

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

Flygut - An atlas of the Drosophila adult midgut

FBgn0261788

Images

Image Based Resources

Alleles, Insertions, Transgenic Constructs, and Aberrations

Classical and Insertion Alleles ( 17 )

For All Classical and Insertion Alleles Show

Other relevant insertions

Transgenic Constructs ( 25 )

For All Alleles Carried on Transgenic Constructs Show

Transgenic constructs containing/affecting coding region of Ank2

Transgenic constructs containing regulatory region of Ank2

Aberrations (Deficiencies and Duplications) ( 7 )

Inferred from experimentation ( 7 )

Gene not disrupted in

(Koch et al., 2008)

(Koch et al., 2008)

(Koch et al., 2008)

(Koch et al., 2008)

Gene disrupted in

(Koch et al., 2008)

(Koch et al., 2008)

(Koch et al., 2008)

Gene partially disrupted in

(Koch et al., 2008)

Inferred from location ( 0 )

Alleles Representing Disease-Implicated Variants

Phenotypes

For more details about a specific phenotype click on the relevant allele symbol.

Lethality

Allele

Ank2^f00518

lethal, with Df(3L)RM5-2

Ank2^f02001

lethal (with Ank2^f00518)

Ank2^f02001

lethal (with Ank2^f02001)

Ank2^f00518

lethal | recessive

Ank2^f02001

lethal - all die before end of larval stage, with Df(3L)RM5-2

Ank2^f00518

lethal - all die before end of larval stage | recessive

Ank2^f00518

viable, with Dcr-2^UAS.cDa, Scer\GAL4^elav.PLu

viable, with Scer\GAL4^Mef2.PR

viable, with Scer\GAL4^pnr-MD237

viable, with Scer\GAL4^tin.CΔ4

Other Phenotypes

Allele

abnormal auditory perception | adult stage

Ank2^f02001

abnormal memory | adult stage, with Scer\GAL4^Mef2.247

Ank2^KK104937

abnormal neuroanatomy

abnormal neuroanatomy, with Df(3L)RM5-2

abnormal neuroanatomy, with Scer\GAL4^IG1-1

Ank2^dsRNA.UAS

abnormal neuroanatomy, with Scer\GAL4^unspecified

abnormal neuroanatomy (with Ank2^f00518)

Ank2^f02001

abnormal neuroanatomy (with Ank2^f02001)

Ank2^f00518

abnormal neuroanatomy | larval stage

abnormal neuroanatomy | larval stage, with Ank2^f00518

abnormal neuroanatomy | larval stage, with Ank2^XL-5xR

Ank2^f00518

abnormal neuroanatomy | larval stage, with Ank2^XL-20xR

Ank2^f00518

abnormal neuroanatomy | larval stage, with Ank2^XL-Δall

Ank2^f00518

abnormal neuroanatomy | larval stage, with Ank2^XL-ΔC

Ank2^f00518

abnormal neuroanatomy | larval stage, with Ank2^XL-ΔR

Ank2^f00518

abnormal neuroanatomy | larval stage, with Dcr-2^UAS.cDa, Scer\GAL4^elav.PLu

Ank2^KK104937

abnormal neuroanatomy | larval stage (with Ank2^K327)

Ank2^RM5-1

abnormal neuroanatomy | larval stage (with Ank2^RM5-1)

Ank2^K327

abnormal neuroanatomy | third instar larval stage

Ank2^f02001

abnormal neuroanatomy | third instar larval stage, with Scer\GAL4^ppk.PG

abnormal neuroanatomy | third instar larval stage (with Ank2^E380)

Ank2^K327

abnormal neuroanatomy | third instar larval stage (with Ank2^f02001)

Ank2^RM5-1

abnormal neuroanatomy | third instar larval stage (with Ank2^K327)

Ank2^E380

abnormal neuroanatomy | third instar larval stage (with Ank2^RM5-1)

Ank2^f02001

abnormal neurophysiology

Ank2^f02001

abnormal neurophysiology | second instar larval stage, with Df(3L)RM5-2

Ank2^f00518

abnormal neurophysiology | third instar larval stage, with Df(3L)RM5-2

Ank2^f02001

abnormal pain response | adult stage, with Dcr-2^UAS.cDa, Scer\GAL4^elav.PLu

Ank2^GD12247

some die during larval stage, with Df(3L)RM5-2

Ank2^f00518

some die during larval stage | recessive

Ank2^f00518

Phenotype manifest in

Allele

axon | larval stage

Ank2^XLΔ

axon | larval stage, with Ank2^f00518

axon | larval stage, with Ank2^XL-5xR

Ank2^f00518

axon | larval stage, with Ank2^XL-20xR

Ank2^f00518

axon | larval stage, with Ank2^XL-Δall

Ank2^f00518

axon | larval stage, with Ank2^XL-ΔC

Ank2^f00518

axon | larval stage, with Ank2^XL-ΔR

Ank2^f00518

axon | third instar larval stage

Ank2^f02001

dendritic tree | third instar larval stage, with Scer\GAL4^ppk.PG

Ank2^GD12247

dorsal multidendritic neuron ddaE & axon, with Scer\GAL4^IG1-1

Ank2^dsRNA.UAS

embryonic/larval neuromuscular junction (with Ank2^E380)

Ank2^K327

embryonic/larval neuromuscular junction (with Ank2^f02001)

Ank2^RM5-1

embryonic/larval neuromuscular junction (with Ank2^K327)

embryonic/larval neuromuscular junction (with Ank2^RM5-1)

embryonic/larval neuromuscular junction | larval stage

embryonic/larval neuromuscular junction | larval stage, with Ank2^f00518

embryonic/larval neuromuscular junction | larval stage, with Ank2^XL-5xR

Ank2^f00518

embryonic/larval neuromuscular junction | larval stage, with Ank2^XL-20xR

Ank2^f00518

embryonic/larval neuromuscular junction | larval stage, with Ank2^XL-Δall

Ank2^f00518

embryonic/larval neuromuscular junction | larval stage, with Ank2^XL-ΔC

Ank2^f00518

embryonic/larval neuromuscular junction | larval stage, with Ank2^XL-ΔR

Ank2^f00518

embryonic/larval neuromuscular junction | larval stage, with Dcr-2^UAS.cDa, Scer\GAL4^elav.PLu

Ank2^KK104937

embryonic/larval neuromuscular junction | third instar larval stage

Ank2^f02001

embryonic/larval peripheral nervous system (with Ank2^E380)

Ank2^K327

embryonic/larval peripheral nervous system (with Ank2^K327)

Ank2^E380

larval multidendritic class IV neuron | third instar larval stage, with Scer\GAL4^ppk.PG

LL1 motor neuron | larval stage

microtubule | larval stage

microtubule | larval stage, with Ank2^f00518

microtubule | larval stage, with Ank2^XL-5xR

Ank2^f00518

microtubule | larval stage, with Ank2^XL-20xR

Ank2^f00518

microtubule | larval stage, with Ank2^XL-Δall

Ank2^f00518

microtubule | larval stage, with Ank2^XL-ΔC

Ank2^f00518

microtubule | larval stage, with Ank2^XL-ΔR

Ank2^f00518

microtubule | third instar larval stage

Ank2^f02001

neuromuscular junction

neuromuscular junction, with Df(3L)RM5-2

neuromuscular junction, with Scer\GAL4^unspecified

neuromuscular junction (with Ank2^f00518)

Ank2^f02001

neuromuscular junction (with Ank2^f02001)

Ank2^f00518

Ank2^f02001

NMJ bouton, with Df(3L)RM5-2

NMJ bouton, with Scer\GAL4^unspecified

Ank2^L8.UAS.Venus

NMJ bouton (with Ank2^E380)

Ank2^K327

NMJ bouton (with Ank2^f02001)

Ank2^RM5-1

NMJ bouton (with Ank2^K327)

Ank2^E380

NMJ bouton (with Ank2^RM5-1)

Ank2^f02001

NMJ bouton | larval stage

synapse | larval stage

synapse | larval stage, with Ank2^f00518

synapse | larval stage, with Ank2^XL-Δall

Ank2^f00518

synapse | larval stage, with Ank2^XL-ΔC

Ank2^f00518

type Ib motor neuron | larval stage

Ank2^XLΔ

type Ib motor neuron | larval stage, with Ank2^f00518

type Ib motor neuron | larval stage, with Ank2^XL-5xR

Ank2^f00518

type Ib motor neuron | larval stage, with Ank2^XL-20xR

Ank2^f00518

type Ib motor neuron | larval stage, with Ank2^XL-Δall

Ank2^f00518

type Ib motor neuron | larval stage, with Ank2^XL-ΔC

Ank2^f00518

type Ib motor neuron | larval stage, with Ank2^XL-ΔR

Ank2^f00518

Orthologs

Downloads

Download All DIOPT Orthologs

Download All OrthoDB Orthologs

Human Orthologs (via DIOPT v8.0)

Homo sapiens (Human) (29)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

6 of 15

Yes

No

5 of 15

No

No

1

5 of 15

No

No

1

3 of 15

No

Yes

2 of 15

No

Yes

2 of 15

No

Yes

1 of 15

No

Yes

1 of 15

No

Yes

1 of 15

No

Yes

1 of 15

No

Yes

1

1 of 15

No

No

1 of 15

No

Yes

1 of 15

No

Yes

1 of 15

No

No

1 of 15

No

Yes

1 of 15

No

Yes

1 of 15

No

Yes

1 of 15

No

Yes

Hsap\FPGT-TNNI3K

1 of 15

No

Yes

Hsap\GPR75-ASB3

1 of 15

No

Yes

1 of 15

No

No

1 of 15

No

Yes

1 of 15

No

Yes

1

1 of 15

No

No

1 of 15

No

Yes

1 of 15

No

No

1 of 15

No

No

1 of 15

No

No

1 of 15

No

No

Model Organism Orthologs (via DIOPT v8.0)

Mus musculus (laboratory mouse) (27)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

6 of 15

Yes

Yes

6 of 15

Yes

No

5 of 15

No

No

2 of 15

No

No

2 of 15

No

Yes

2 of 15

No

Yes

1 of 15

No

Yes

1 of 15

No

Yes

1 of 15

No

Yes

1 of 15

No

No

1 of 15

No

No

1 of 15

No

Yes

1 of 15

No

Yes

1 of 15

No

No

1 of 15

No

Yes

1 of 15

No

Yes

1 of 15

No

Yes

1 of 15

No

Yes

1 of 15

No

No

1 of 15

No

No

1 of 15

No

Yes

1 of 15

No

No

1 of 15

No

No

1 of 15

No

No

1 of 15

No

No

1 of 15

No

Yes

1 of 15

No

No

Rattus norvegicus (Norway rat) (18)

4 of 13

Yes

No

3 of 13

No

Yes

3 of 13

No

No

2 of 13

No

Yes

2 of 13

No

No

2 of 13

No

Yes

1 of 13

No

Yes

1 of 13

No

Yes

1 of 13

No

No

1 of 13

No

No

1 of 13

No

Yes

1 of 13

No

Yes

1 of 13

No

Yes

1 of 13

No

No

Rnor\LOC100911519

1 of 13

No

No

1 of 13

No

Yes

1 of 13

No

Yes

1 of 13

No

No

Xenopus tropicalis (Western clawed frog) (15)

4 of 12

Yes

No

3 of 12

No

No

3 of 12

No

No

Xtro\LOC100492885

2 of 12

No

No

1 of 12

No

Yes

1 of 12

No

Yes

1 of 12

No

No

1 of 12

No

Yes

1 of 12

No

Yes

1 of 12

No

Yes

1 of 12

No

Yes

1 of 12

No

No

Xtro\LOC100497775

1 of 12

No

Yes

1 of 12

No

No

1 of 12

No

Yes

Danio rerio (Zebrafish) (25)

4 of 15

Yes

Yes

4 of 15

Yes

No

3 of 15

No

No

3 of 15

No

No

3 of 15

No

No

3 of 15

No

Yes

2 of 15

No

Yes

2 of 15

No

Yes

2 of 15

No

Yes

2 of 15

No

Yes

2 of 15

No

No

1 of 15

No

Yes

1 of 15

No

Yes

1 of 15

No

Yes

1 of 15

No

Yes

1 of 15

No

No

1 of 15

No

No

1 of 15

No

Yes

1 of 15

No

No

Drer\LOC100535451

1 of 15

No

No

1 of 15

No

No

1 of 15

No

No

1 of 15

No

No

1 of 15

No

Yes

1 of 15

No

No

Caenorhabditis elegans (Nematode, roundworm) (19)

9 of 15

Yes

Yes

2 of 15

No

No

1 of 15

No

Yes

1 of 15

No

Yes

1 of 15

No

Yes

1 of 15

No

Yes

1 of 15

No

Yes

1 of 15

No

Yes

1 of 15

No

Yes

1 of 15

No

No

1 of 15

No

Yes

1 of 15

No

Yes

1 of 15

No

Yes

1 of 15

No

Yes

1 of 15

No

Yes

1 of 15

No

Yes

1 of 15

No

Yes

1 of 15

No

Yes

1 of 15

No

No

Arabidopsis thaliana (thale-cress) (31)

3 of 9

Yes

Yes

2 of 9

No

Yes

2 of 9

No

Yes

2 of 9

No

Yes

2 of 9

No

Yes

2 of 9

No

Yes

2 of 9

No

Yes

2 of 9

No

Yes

2 of 9

No

Yes

2 of 9

No

Yes

1 of 9

No

Yes

1 of 9

No

Yes

1 of 9

No

Yes

1 of 9

No

Yes

1 of 9

No

Yes

1 of 9

No

Yes

1 of 9

No

Yes

1 of 9

No

Yes

1 of 9

No

Yes

1 of 9

No

Yes

1 of 9

No

Yes

1 of 9

No

Yes

1 of 9

No

Yes

1 of 9

No

Yes

1 of 9

No

Yes

1 of 9

No

Yes

1 of 9

No

No

1 of 9

No

No

1 of 9

No

Yes

1 of 9

No

Yes

1 of 9

No

Yes

Saccharomyces cerevisiae (Brewer's yeast) (5)

2 of 15

Yes

No

2 of 15

Yes

Yes

1 of 15

No

Yes

1 of 15

No

No

1 of 15

No

No

Schizosaccharomyces pombe (Fission yeast) (2)

Spom\SPAC6C3.08

1 of 12

Yes

No

Spom\SPBP16F5.05c

1 of 12

Yes

Yes

Ortholog(s) in Drosophila Species (via OrthoDB v9.1) ( EOG09190034 )

Organism

Common Name

Gene

AAA Syntenic Ortholog

Multiple Dmel Genes in this Orthologous Group

Drosophila suzukii

Spotted wing Drosophila

Dsuz\DS10_00007790

Drosophila simulans

Drosophila sechellia

Drosophila sechellia

Drosophila erecta

Drosophila yakuba

Drosophila ananassae

Drosophila pseudoobscura pseudoobscura

Drosophila persimilis

Drosophila persimilis

Drosophila willistoni

Drosophila willistoni

Drosophila willistoni

Drosophila virilis

Drosophila virilis

Drosophila virilis

Drosophila mojavensis

Drosophila grimshawi

Drosophila grimshawi

Orthologs in non-Drosophila Dipterans (via OrthoDB v9.1) ( EOG091500AK )

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Musca domestica

House fly

Musca domestica

House fly

Glossina morsitans

Tsetse fly

Gmor\GMOY004046

Glossina morsitans

Tsetse fly

Gmor\GMOY007003

Lucilia cuprina

Australian sheep blowfly

Lcup\FF38_06100

Lucilia cuprina

Australian sheep blowfly

Lcup\FF38_00078

Mayetiola destructor

Hessian fly

Mdes\Mdes007490

Aedes aegypti

Yellow fever mosquito

Aaeg\AAEL014668

Aedes aegypti

Yellow fever mosquito

Aaeg\AAEL013466

Aedes aegypti

Yellow fever mosquito

Aaeg\AAEL014742

Aedes aegypti

Yellow fever mosquito

Aaeg\AAEL018218

Anopheles darlingi

American malaria mosquito

Adar\ADAC008153

Anopheles darlingi

American malaria mosquito

Adar\ADAC004422

Anopheles gambiae

Malaria mosquito

Agam\AGAP009937

Anopheles gambiae

Malaria mosquito

Agam\AGAP002272

Culex quinquefasciatus

Southern house mosquito

Cqui\CPIJ002592

Culex quinquefasciatus

Southern house mosquito

Cqui\CPIJ017435

Culex quinquefasciatus

Southern house mosquito

Cqui\CPIJ017156

Culex quinquefasciatus

Southern house mosquito

Cqui\CPIJ010503

Orthologs in non-Dipteran Insects (via OrthoDB v9.1) ( EOG090W01CK )

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Bombyx mori

Silkmoth

Bmor\BGIBMGA013427

Danaus plexippus

Monarch butterfly

Dple\DPOGS215446-PA

Danaus plexippus

Monarch butterfly

Dple\DPOGS208611-PA

Danaus plexippus

Monarch butterfly

Dple\DPOGS208612-PA

Heliconius melpomene

Postman butterfly

Hmel\HMEL016592

Heliconius melpomene

Postman butterfly

Hmel\HMEL022584

Apis florea

Little honeybee

Aflo\2173067572

Apis florea

Little honeybee

Aflo\2645637412

Apis florea

Little honeybee

Aflo\2147549443

Apis mellifera

Western honey bee

Apis mellifera

Western honey bee

Bombus impatiens

Common eastern bumble bee

Bombus impatiens

Common eastern bumble bee

Bombus terrestris

Buff-tailed bumblebee

Bombus terrestris

Buff-tailed bumblebee

Linepithema humile

Argentine ant

Linepithema humile

Argentine ant

Linepithema humile

Argentine ant

Linepithema humile

Argentine ant

Megachile rotundata

Alfalfa leafcutting bee

Mrot\MROTU:000088

Megachile rotundata

Alfalfa leafcutting bee

Mrot\MROTU:00160e

Nasonia vitripennis

Parasitic wasp

Nvit\Nasvi2EG010051

Nasonia vitripennis

Parasitic wasp

Nvit\Nasvi2EG011994

Nasonia vitripennis

Parasitic wasp

Nvit\Nasvi2EG011990

Dendroctonus ponderosae

Mountain pine beetle

Dendroctonus ponderosae

Mountain pine beetle

Dendroctonus ponderosae

Mountain pine beetle

Dendroctonus ponderosae

Mountain pine beetle

Tribolium castaneum

Red flour beetle

Tribolium castaneum

Red flour beetle

Pediculus humanus

Human body louse

Phum\PHUM596790

Pediculus humanus

Human body louse

Phum\PHUM570530

Rhodnius prolixus

Kissing bug

Rpro\RPRC013282

Rhodnius prolixus

Kissing bug

Rpro\RPRC005328

Cimex lectularius

Bed bug

Clec\CLEC008268

Cimex lectularius

Bed bug

Clec\CLEC008267

Cimex lectularius

Bed bug

Clec\CLEC006601

Acyrthosiphon pisum

Pea aphid

Apim\ACYPI000387

Acyrthosiphon pisum

Pea aphid

Apim\ACYPI38268

Zootermopsis nevadensis

Nevada dampwood termite

Znev\Znev_13436

Zootermopsis nevadensis

Nevada dampwood termite

Znev\Znev_11206

Orthologs in non-Insect Arthropods (via OrthoDB v9.1) ( EOG090X02VS )

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Strigamia maritima

European centipede

Smar\SMAR009688

Ixodes scapularis

Black-legged tick

Isca\ISCW018406

Stegodyphus mimosarum

African social velvet spider

Smim\KFM71126.1

Stegodyphus mimosarum

African social velvet spider

Smim\KFM62264.1

Tetranychus urticae

Two-spotted spider mite

Turt\tetur15g02730

Daphnia pulex

Water flea

Dpux\DAPPUDRAFT_5038

Daphnia pulex

Water flea

Dpux\DAPPUDRAFT_115883

Daphnia pulex

Water flea

Dpux\DAPPUDRAFT_57940

Daphnia pulex

Water flea

Dpux\DAPPUDRAFT_34645

Daphnia pulex

Water flea

Dpux\DAPPUDRAFT_6634

Daphnia pulex

Water flea

Dpux\DAPPUDRAFT_17028

Daphnia pulex

Water flea

Dpux\DAPPUDRAFT_36579

Daphnia pulex

Water flea

Dpux\DAPPUDRAFT_237748

Daphnia pulex

Water flea

Dpux\DAPPUDRAFT_95004

Daphnia pulex

Water flea

Dpux\DAPPUDRAFT_1835

Daphnia pulex

Water flea

Dpux\DAPPUDRAFT_63811

Daphnia pulex

Water flea

Dpux\DAPPUDRAFT_17024

Daphnia pulex

Water flea

Dpux\DAPPUDRAFT_98757

Daphnia pulex

Water flea

Dpux\DAPPUDRAFT_6638

Daphnia pulex

Water flea

Dpux\DAPPUDRAFT_333611

Daphnia pulex

Water flea

Dpux\DAPPUDRAFT_257448

Orthologs in non-Arthropod Metazoa (via OrthoDB v9.1) ( EOG091G00GN )

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Strongylocentrotus purpuratus

Purple sea urchin

Strongylocentrotus purpuratus

Purple sea urchin

Spur\Sp-Sema/Fn3

Strongylocentrotus purpuratus

Purple sea urchin

Spur\Sp-Sema/Psi_2

Strongylocentrotus purpuratus

Purple sea urchin

Spur\Sp-Unc44_161

Strongylocentrotus purpuratus

Purple sea urchin

Spur\SPU_019638gn

Strongylocentrotus purpuratus

Purple sea urchin

Spur\Sp-Unc44_173

Strongylocentrotus purpuratus

Purple sea urchin

Strongylocentrotus purpuratus

Purple sea urchin

Spur\Sp-Unc44_210

Strongylocentrotus purpuratus

Purple sea urchin

Spur\Sp-Unc44_284

Strongylocentrotus purpuratus

Purple sea urchin

Spur\Sp-Plxna4L_1

Strongylocentrotus purpuratus

Purple sea urchin

Spur\Sp-PlxnaL_1

Strongylocentrotus purpuratus

Purple sea urchin

Spur\Sp-Sema/Psi

Strongylocentrotus purpuratus

Purple sea urchin

Spur\Sp-Unc44L_57

Strongylocentrotus purpuratus

Purple sea urchin

Strongylocentrotus purpuratus

Purple sea urchin

Spur\Sp-Unc44_128

Strongylocentrotus purpuratus

Purple sea urchin

Spur\Sp-Unc44_341

Strongylocentrotus purpuratus

Purple sea urchin

Spur\Sp-Plxnb2L

Strongylocentrotus purpuratus

Purple sea urchin

Strongylocentrotus purpuratus

Purple sea urchin

Strongylocentrotus purpuratus

Purple sea urchin

Spur\Sp-Unc44L_15

Strongylocentrotus purpuratus

Purple sea urchin

Spur\Sp-Unc44_333

Strongylocentrotus purpuratus

Purple sea urchin

Spur\Sp-Sema/Psi_3

Ciona intestinalis

Vase tunicate

Cint\LOC100176624

Ciona intestinalis

Vase tunicate

Cint\ENSCING00000022838

Gallus gallus

Domestic chicken

Ggal\ENSGALG00000003594

Gallus gallus

Domestic chicken

Ggal\ENSGALG00000007815

Gallus gallus

Domestic chicken

Gallus gallus

Domestic chicken

Paralogs

Downloads

Download All DIOPT Paralogs

Paralogs (via DIOPT v8.0)

Drosophila melanogaster (Fruit fly) (13)

Gene Symbol

Score

Source

Alignment

5 of 10

2 of 10

2 of 10

1 of 10

1 of 10

1 of 10

1 of 10

1 of 10

1 of 10

1 of 10

1 of 10

1 of 10

1 of 10

Human Disease Associations

FlyBase Human Disease Model Reports

intellectual disability, autosomal recessive 37

Disease Model Summary Ribbon

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 2 )

Allele

Disease

Evidence

References

model of intellectual disability

CEA

(Iqbal et al., 2013)

model of Alzheimer's disease

CEA

(Higham et al., 2019)

model of Alzheimer's disease

CEA

(Higham et al., 2019)

Potential Models Based on Orthology ( 1 )

Human Ortholog

Disease

Evidence

References

ANK2; ankyrin 2

model of ankyrin-B-related cardiac arrhythmia

IEA

(FlyBase, 2019-)

Modifiers Based on Experimental Evidence ( 0 )

Allele

Disease

Interaction

References

Disease Associations of Human Orthologs (via DIOPT v8.0 and OMIM)

Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.

Homo sapiens (Human)

Gene name

Score

OMIM

OMIM Phenotype

DO term

Complementation?

Transgene?

ANK2; ankyrin 2

6 of 15

CARDIAC ARRHYTHMIA, ANKYRIN-B-RELATED

ankyrin-B-related cardiac arrhythmia

ANK1; ankyrin 1

5 of 15

SPHEROCYTOSIS, TYPE 1; SPH1

hereditary spherocytosis type 1

ANK3; ankyrin 3

5 of 15

MENTAL RETARDATION, AUTOSOMAL RECESSIVE 37; MRT37

autosomal recessive non-syndromic intellectual disability

ANKRD44; ankyrin repeat domain 44

3 of 15

Functional Complementation Data

Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.

Interactions

Summary of Physical Interactions

esyN Network Diagram

Interactions Browser

View in Interactions Browser

Please see the Physical Interaction reports below for full details

protein-protein

Physical Interaction

Assay

References

(Hu et al., 2017.6.13)

(Hu et al., 2017.6.13)

(Hu et al., 2017.6.13)

two hybrid, pull down, western blot

(Lüchtenborg et al., 2014)

anti tag coimmunoprecipitation, anti tag western blot, anti bait coimmunoprecipitation, western blot

(Enneking et al., 2013)

(Hu et al., 2017.6.13)

(Hu et al., 2017.6.13)

(Hu et al., 2017.6.13)

anti bait coimmunoprecipitation, western blot

(Stephan et al., 2015)

(Hu et al., 2017.6.13)

(Hu et al., 2017.6.13)

(Hu et al., 2017.6.13)

(Hu et al., 2017.6.13)

Summary of Genetic Interactions

esyN Network Diagram

esyN Network Key:

Suppression

Enhancement

View in Interactions Browser

Please look at the allele data for full details of the genetic interactions

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

suppressible

(Bulat et al., 2014)

enhanceable

(Bulat et al., 2014)

suppressible

(Migh et al., 2018)

enhanceable

(Migh et al., 2018)

suppressible

(Keller et al., 2011)

suppressible

(Keller et al., 2011)

suppressible

(Keller et al., 2011)

suppressible

(Keller et al., 2011)

suppressible

(Stephan et al., 2015)

suppressible

(Keller et al., 2011)

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

enhanceable

(Bulat et al., 2014)

suppressible

(Migh et al., 2018)

enhanceable

(Migh et al., 2018)

suppressible

(Stephan et al., 2015)

enhanceable

(Stephan et al., 2015)

External Data

Linkouts

DroID - A comprehensive database of gene and protein interactions.

FBgn0261788

MIST (genetic) - An integrated Molecular Interaction Database

Ank2

MIST (protein-protein) - An integrated Molecular Interaction Database

Ank2

Pathways

Signaling Pathways (FlyBase)

Metabolic Pathways

External Data

Linkouts

KEGG Pathways - Wiring diagrams of molecular interactions, reactions and relations.

Toll and Imd signaling pathway

Genomic Location and Detailed Mapping Data

Chromosome (arm)

3L

Recombination map

3-21

Cytogenetic map

Sequence location

3L:7,655,389..7,718,395 [-]

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

66A10-66A10

Limits computationally determined from genome sequence between P{PZ}l(3)07217⁰⁸²²³&P{EP}Rac2^EP3118 and P{lacW}Nmt^j1C7

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

66A-66A

(Hortsch, 1999.9.28)

66A8-66A9

(Serano, 2000.2.28)

66A-66A

(determined by in situ hybridisation)

(EDGP Project Members, 1994-)

Experimentally Determined Recombination Data

Location

3-21

(FlyBase, 2016)

3-17.8

(Comeron et al., 2012)

Left of (cM)

Right of (cM)

Notes

Stocks and Reagents

Stocks (17)

29438

y¹ v¹; P{TRiP.JF03374}attP2

23488

w¹¹¹⁸; Mi{ET1}CG32373^MB02773 Ank2^MB02773

24715

w¹¹¹⁸; Mi{ET1}Ank2^MB04517 CG32373^MB04517

35964

y¹ w^*; Mi{MIC}Ank2^MI02111 CG32373^MI02111

36140

y¹ w^*; Mi{MIC}Ank2^MI01704 CG32373^MI01704

36144

y¹ w^*; Mi{MIC}Ank2^MI02275 CG32373^MI02275

57963

y¹ w^*; Mi{MIC}Ank2^MI12604 CG32373^MI12604

22665

y¹ w^67c23; Mi{ET1}CG32373^MB00005 Ank2^MB00005

v104833

P{KK113612}VIE-260B

v107238

P{KK104937}VIE-260B

v107369

P{KK106729}VIE-260B

v26121

w¹¹¹⁸; P{GD10869}v26121

More stocks available...

Genomic Clones (50)

Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

cDNA Clones (116)

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequenced

BDGP DGC clones

Other clones

Drosophila Genomics Resource Center cDNA clones

For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

FBgn0261788

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

Other clones

RNAi and Array Information

Linkouts

DRSC - Results frm RNAi screens

FBgn0261788

GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents

38863

Antibody Information

Laboratory Generated Antibodies

monoclonal

(Enneking et al., 2013)

polyclonal

(Koch et al., 2008, Hortsch et al., 2002, Bouley et al., 2000)

Commercially Available Antibodies

Other Information

Relationship to Other Genes

Source for database identify of

Source for identity of: SP2523 CG7493

(FlyBase, 1996-)

Source for database merge of

Source for merge of: Ank2 SP2523 CG32375 CG34121

(FlyBase Genome Annotators, 2007)

Source for merge of: Ank2 CG32377

(Koch et al., 2008)

Additional comments

Annotations CG34416 and CG32377 merged as CG42734 (which corresponds to Ank2) in release 5.27 of the genome annotation.

(FlyBase Genome Annotators, 2010)

Annotations CG7462, CG32375, CG34158 and CG34121 merged as CG34416 in release 5.2 of the genome annotation.

(FlyBase Genome Annotators, 2007)

FlyBase curator comment: The symbol "CG18768" has been used erroneously in FlyBase to name 2 adjacent annotations in different releases of the genome annotation. The two annotations have been renamed in release 5.1 to avoid confusion; they are CG34158 (which corresponds to SP2523) and CG34121. CG34121 was labelled "CG18768" in release 2 of the genome annotation and was not annotated in releases 3.0 through 4.3, but has been reinstated (as CG34121) in release 5.1 of the genome annotation. CG34158 (which corresponds to SP2523) was labelled "CG7493" in release 2 of the genome annotation, was labelled "CG18768" in releases 3.0 through 4.3, and has been renamed CG34158 in release 5.1 of the genome annotation.

(FlyBase Genome Annotators, 2006)

Source for identity of SP2523 CG7493 was sequence comparison ( date:000414 ).

(FlyBase, 1996-)

Other Comments

dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R⁺ cell morphology.

(Kiger et al., 2003)

New annotation (CG32375) in release 3 of the genome annotation.

(FlyBase Genome Annotators, 2002-2003)

New annotation (CG32377) in release 3 of the genome annotation.

(FlyBase Genome Annotators, 2002-2003)

Identification: as a protein that interacts with both Nrg isoforms in a yeast two-hybrid assay.

(Bouley et al., 2000)

The existence of this gene is tentative, and is based on a match of an STS sequence from a European Drosophila Genome Mapping Project cosmid.

Origin and Etymology

Discoverer

Etymology

Identification

External Crossreferences and Linkouts ( 134 )

Sequence Crossreferences

NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.

38863

GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.

GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.

RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.

UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information

Other crossreferences

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0261788

Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones

FBgn0261788

DRscDB

38863/tissue=All

EMBL-EBI Single Cell Expression Atlas

FBgn0261788

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

Flygut - An atlas of the Drosophila adult midgut

FBgn0261788

FlyMine - An integrated database for Drosophila genomics

FBgn0261788

GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents

38863

iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)

InterPro - A database of protein families, domains and functional sites

KEGG Genes - Molecular building blocks of life in the genomic space.

Dmel_CG42734

MARRVEL_MODEL

38863

modMine - A data warehouse for the modENCODE project

FBgn0261788

SignaLink - A signaling pathway resource with multi-layered regulatory networks.

A8JNM5

Linkouts

DroID - A comprehensive database of gene and protein interactions.

FBgn0261788

DRSC - Results frm RNAi screens

FBgn0261788

Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution

Interactive Fly

KEGG Pathways - Wiring diagrams of molecular interactions, reactions and relations.

Toll and Imd signaling pathway

MIST (genetic) - An integrated Molecular Interaction Database

Ank2

MIST (protein-protein) - An integrated Molecular Interaction Database

Ank2

Synonyms and Secondary IDs (26)

Reported As

Symbol Synonym

CG18025

CG18227

CG18768

CG32373

(Pielage et al., 2008)

CG32375

CG32377

(Huang et al., 2013, Japanese National Institute of Genetics, 2012.5.21, Rodriguez et al., 2012, Koch et al., 2008, Koch et al., 2007)

CG34121

CG34158

(FlyBase Genome Annotators, 2006)

CG34416

(Rodriguez et al., 2012, Khanna et al., 2010, Keleman et al., 2009.8.5, Perkins et al., 2009, FlyBase Genome Annotators, 2007)

CG42734

(Schwartz et al., 2016, FlyBase Genome Annotators, 2010, Ni et al., 2010.12.1)

CG7462

(Hortsch, 2002.5.1, Hortsch, 2002.5.1, Hortsch, 2002.5.1, Hortsch, 2002.5.1, Goldstein and Gunawardena, 2000, Vernooy et al., 2000)

CG7493

DAnk2

(Mazock et al., 2010)

Dank2

(Hortsch et al., 2002, Hortsch et al., 2002, Bouley et al., 2000)

ESTS:149B10S

(Bolshakov et al., 2002, EDGP Project Members, 1994-)

SP2523

(Koch et al., 2008, Pielage et al., 2008, Koch et al., 2007)

ank2

(Orr et al., 2020, Qu et al., 2017, Friedrich et al., 2016, Siegenthaler et al., 2015, Lüchtenborg et al., 2014, Westholm et al., 2014, Nechipurenko and Broihier, 2012, Keller et al., 2011, Kurshan et al., 2009, Koch et al., 2008, Pielage et al., 2008, Yamamoto et al., 2006)

ank2-L

(Massaro et al., 2009)

dank2

(Koch et al., 2007)

sp2523

(Michaut et al., 2003)

Name Synonyms

Ank2

Ankyrin 2

(Bodaleo and Gonzalez-Billault, 2016, Mossman et al., 2016, Pool et al., 2012, Banovic et al., 2010, Khanna et al., 2010)

Ankyrin2

(Stephan et al., 2015, Bulat et al., 2014, Enneking et al., 2013)

Ankyrin2 extra large

(Friedrich et al., 2016)

CG32375

CG34121

Dank2

(Hortsch et al., 2002)

SP2523

ankyrin2

(Keller et al., 2011)

ankyrin2-XL

(Kurshan et al., 2009)

Secondary FlyBase IDs

FBgn0085445
FBgn0042181
FBgn0035810
FBgn0035809
FBgn0035808
FBgn0017645
FBgn0083993
FBgn0052375
FBgn0083957
FBgn0052377
FBgn0261687

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Project

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Title

References (123)

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