A Database of Drosophila Genes & Genomes

FB2012_01, released January 20th, 2012
 

Gene Dmel\kcc

General Information
SymbolDmel\kccSpeciesD. melanogaster
NamekazachocAnnotation symbolCG5594
Feature typeprotein_coding_geneFlyBase IDFBgn0261794
Gene Model StatusCurrent Stock availability 11 publicly available
Genomic Location
Chromosome (arm)2RRecombination map
Cytogenetic map60A9-60A11Sequence location2R:19,795,651..19,812,619 [+]

Genomic Maps

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Automatically generated summary

See sections below for more information
The gene kazachoc is referred to in FlyBase by the symbol Dmel\kcc (CG5594, FBgn0261794). It is a protein_coding_gene from Drosophila melanogaster. There is experimental evidence that it has the molecular function: potassium:chloride symporter activity. There is experimental evidence that it is involved in the biological process: response to mechanical stimulus; mechanosensory behavior. 15 alleles are reported. No phenotypic data is available. It has 4 annotated transcripts and 4 annotated polypeptides. Protein features are: Amino acid permease domain; K-Cl co-transporter; Na/K/Cl co-transporter superfamily. Gene sequence location is 2R:19795651..19812619.

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Description
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FB2011_10
Controlled Vocabulary Terms
FB2012_01
Sequence features
Controlled Vocabulary Terms
All updates Click here to see a list of all updates to this record from FB2010_08 and on.
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FlyBase Computed Cytological Location
Cytogenetic map
Evidence for location
60A9-60A11  
Limits computationally determined from genome sequence between P{lacW}kenk11035&P{EP}CG17658EP730 and P{EP}TalEP489&P{EP}CG3065EP316  
Experimentally Determined Cytological Location
Cytogenetic map
Notes
References
88A-88A  
(determined by in situ hybridisation)  
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
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Please see the GBrowse view of Dmel\kcc for information on other features
To submit a correction to a gene model please use the Contact FlyBase form
detailed view FBtr0305990 FBtr0305989 FBtr0072219 FBtr0072136 FBtr0072137 FBtr0072139 FBtr0072138 FBtr0072140 FBtr0072215 FBpp0297132 FBpp0072128 FBpp0297131 FBpp0072046 FBpp0072045 FBpp0072047 FBpp0072048 FBpp0072049 FBti0039767 FBti0103186 FBti0036886 FBti0036839 FBti0029428 FBti0111263 FBti0052838 FBti0067431 FBti0045212 FBti0021394 FBti0066819 FBti0066595 FBti0125404 FBti0043223 FBti0112960 FBti0047985 FBti0039524 FBti0021267 FBti0028492 FBti0040129 FBti0076288
Comments on Gene Model
hide Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Associated CDS (aa)
FBtr0072136
  3813
  1043
FBtr0072138
  3642
  1028
FBtr0072139
  3735
  1059
FBtr0072137
  3906
  1074
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
hide Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
RefSeq ID
GenBank protein
kcc-PA  
FBpp0072045  
115.7  
1043  
6.69  
kcc-PB  
FBpp0072047  
114.1  
1028  
7.11  
kcc-PC  
FBpp0072048  
117.6  
1059  
6.97  
kcc-PD  
FBpp0072046  
119.3  
1074  
6.65  
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences
InterPro domains - A database of protein families, domains, and functional sites
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DDBJ /
EMBL /
GenBank
DNA sequence
Protein sequence
Name
 
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL
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Mapped Features have been reorganized, please see this article for details.
Additional mapped features and mutations can be found on GBrowse or related reports.
Type
Symbol & Location
Additional Notes
References
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Crossreferences
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hideTranscript Expression
RT-PCR
Stage
Tissue/Position (including subcellular localization)
Reference
Comment:reference stages "body"
Comment:reference stages "body"
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
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mass spectroscopy
Stage
Tissue/Position (including subcellular localization)
Reference
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
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or
Untitled Document detailed view Nap1-RB Nap1-RA kcc-RD kcc-RA kcc-RC kcc-RB CG2812-RA
See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes.
modENCODE Temporal Expression Data (Graveley et al., 2011)
FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
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Lethality
Allele
Other Phenotypes
Allele
Phenotype manifest in
Allele
hide Classical Alleles ( 10 )
For All Classical Alleles Show

Allele of kccClassMutagenStocksKnown lesion
kccAd-42 --
kccEY083042 --
kccc005341 --
kcce029191 --
kccKG02390
1 --
kccP20-1801 --
kccDHS10 Yes
kcce01150
0 --
kcce026010 --
kccML10 Yes
hide Alleles Carried on Transgenic Constructs ( 5 )
For All Alleles Carried on Transgenic Constructs Show

Allele of kccClassMutagenStocksKnown lesion
kccGD35651 Yes
kccHMS010581 Yes
kccKK1079651 Yes
kccScer\UAS.cHb0 Yes
kccScer\UAS.cHd0 Yes
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Not disrupted in
Disrupted in
Duplicated in
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Transgenic Constructs
Type of construct
Name
Expression data
Insertions
Type of insertions
Name
Expression data
insertion of mobile activating element
insertion of enhancer trap
hide Gene Ontology: Function, Process & Cellular Component ( 9 unique terms )
hide Terms Based on Experimental Evidence ( 3 terms )
Molecular Function
CV term
References
Biological Process
CV term
References
inferred from mutant phenotype
Cellular Component ( 0 terms)
hide Terms Based on Predictions or Assertions ( 7 terms )
Molecular Function
CV term
References
inferred from sequence or structural similarity with Eaat1
inferred from sequence or structural similarity with EMBL:AF047339 AND inferred from sequence or structural similarity with NCBI_gi:4826780
Biological Process
CV term
References
inferred from sequence or structural similarity with Eaat1
inferred from sequence or structural similarity with EMBL:AF047339
Cellular Component
CV term
References
inferred from sequence or structural similarity with mouse Slc12a4
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Protein-protein
Interacting group
Assay
References
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Interacts with
Please look at the allele data for full details of the genetic interactions
kcc allele
Gene
References
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Linkouts
DroID - A comprehensive database of gene and protein interactions.
InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets.
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Genome-wide drosophilid orthologs
Curated drosophilid orthologs
Linkouts
OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs.
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Bloomington
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VDRC
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Please Note
This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
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BDGP DGC clones
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cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones
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Source for database identity of
Source for database merge of
Source for merge of: BEST:CK01510 CG2768
Source for merge of: BEST:CK01510 CG5594
Additional comments
Source for merge of BEST:CK01510 CG5594 was a shared cDNA (date:010720).
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Identification: cDNA screen for secreted and transmembrane proteins expressed during embryogenesis.
Annotations CG2768, CG5594 merged as CG5594 in release 3 of the genome annotation, April 2002.
 
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Sequence Crossreferences
RefSeq (Transcripts)
RefSeq (Proteins)
Entrez Gene - A searchable database of RefSeq genes.
Other Crossreferences
InterPro domains - A database of protein families, domains, and functional sites
Linkouts
DroID - A comprehensive database of gene and protein interactions.
DRSC - Results from RNAi screens.
FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans
GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents
InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets.
modMine - Data generated by the modENCODE project.
OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs.
hide Synonyms & Secondary IDs ( 12 )
Reported As
Symbol Synonym
BEST:CK01510
CG2768
 
E(sda)J
 
unnamed
Name Synonym
E(sda)J
 
lethal (2) 60A-C
 
Secondary FlyBase IDs
  • FBgn0025698
  • FBgn0027189
  • FBgn0034929
  • FBgn0034930
  • FBgn0066124
  • FBgn0086754
hide References ( 35 )
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hide Recent research papers ( 3 )
Baycin-Hizal et al., 2011, J. Proteome Res. 10(6): 2777--2784
GlycoFly: A Database of Drosophila N-linked Glycoproteins Identified Using SPEG-MS Techniques. [FBrf0213834]
Leiserson et al., 2011, Glia 59(2): 320--332
Drosophila glia use a conserved cotransporter mechanism to regulate extracellular volume. [FBrf0212638]
Hekmat-Scafe et al., 2010, Genetics 184(1): 171--183
Seizure sensitivity is ameliorated by targeted expression of k+-cl- cotransporter function in the mushroom body of the Drosophila brain. [FBrf0209683]