General Information
Symbol
Dmel\Dhc64C
Species
D. melanogaster
Name
Dynein heavy chain 64C
Annotation Symbol
CG7507
Feature Type
FlyBase ID
FBgn0261797
Gene Model Status
Stock Availability
Enzyme Name (EC)
Adenosinetriphosphatase (3.6.1.3)
Minus-end-directed kinesin ATPase (3.6.4.5)
Gene Snapshot
Dynein heavy chain 64C (Dhc64C) is the heavy chain subunit of the cytoplasmic dynein motor complex. The Dhc64C heavy chain dimer binds and hydrolyzes ATP, providing the power for movement of dynein. Dhc64C has an essential function in oocyte polarity, mitotic cell division, embryonic development, and neuronal transport and neurogenesis. [Date last reviewed: 2016-08-18]
Also Known As
Dhc, Dhc64, cDhc64C, Su(Gl)77, Fs(3)Lab
Genomic Location
Cytogenetic map
Sequence location
3L:4,807,368..4,825,687 [-]
Recombination map
3-12
Sequence
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
GO Summary Ribbons
Families, Domains and Molecular Function
Gene Group Membership (FlyBase)
Protein Family (UniProt, Sequence Similarities)
Belongs to the dynein heavy chain family. (P37276)
Catalytic Activity (EC)
Experimental Evidence
ATP + H(2)O = ADP + phosphate (3.6.1.3)
Predictions / Assertions
ATP + H(2)O = ADP + phosphate (3.6.1.3)
ATP + H(2)O = ADP + phosphate (3.6.4.5)
Summaries
Gene Group Membership
CYTOPLASMIC DYNEIN HEAVY CHAINS -
Dynein heavy chains are minus end-directed microtubule motor proteins. Cytoplasmic dynein complexes are assembled from a cytoplasmic dynein heavy chain homodimer together with homodimeric intermediate chain, light-intermediate chain and light chain dynein subunits. Cytoplasmic dynein complexes participate in many cytoplasmic transport activities such as vesicle transport, organelle transport and mitotic spindle assembly. Some cytoplasmic dyneins specifically participate in intraflagellar transport. (Adapted from PMID:24064538).
UniProt Contributed Function Data
Cytoplasmic dynein acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. Dynein has ATPase activity; the force-producing power stroke is thought to occur on release of ADP.
(UniProt, P37276)
Phenotypic Description from the Red Book (Lindsley and Zimm 1992)
Su(Gl)77
Reduces the severity of Gl in flies raised at either 18 or 29. The most severe allele shows more normal facet arrays in the anterior than in the posterior part of the eye. The lamina cell body layer is thicker than normal in its posterior region and the lamina neuropil is somewhat misshapen, particularly anteriorly. The medulla is abnormally rotated, its posterior edge directly apposed to the lamina, but it is more normally organized than in Gl. The familiar abnormal projections from the posterior lamina through the medulla are present. The second optic chiasma is also divided into several tracts. In less extreme cases, the medulla is only slightly rotated and the second optic chiasma is normal.
Interactive Fly
a molecular motor that functions in axon transport - Dynein-Dynactin complex is essential for dendritic restriction of an isoform of Dscam
Gene Model and Products
Number of Transcripts
8
Number of Unique Polypeptides
8

Please see the GBrowse view of Dmel\Dhc64C or the JBrowse view of Dmel\Dhc64C for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Comments on Gene Model
Gene model reviewed during 5.45
Sequence Ontology: Class of Gene
Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
FBtr0073359
14153
4639
FBtr0273370
14150
4638
FBtr0332745
14371
4651
FBtr0332746
14177
4647
FBtr0332747
14192
4652
FBtr0332748
14362
4648
FBtr0332749
14398
4660
FBtr0332750
14401
4661
Additional Transcript Data and Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
RefSeq ID
GenBank
FBpp0073215
530.2
4639
6.25
FBpp0271878
529.9
4638
6.24
FBpp0304986
531.4
4651
6.28
FBpp0304987
530.8
4647
6.24
FBpp0304988
531.7
4652
6.29
FBpp0304989
531.1
4648
6.25
FBpp0304990
532.3
4660
6.28
FBpp0304991
532.6
4661
6.29
Polypeptides with Identical Sequences

None of the polypeptides share 100% sequence identity.

Additional Polypeptide Data and Comments
Reported size (kDa)
Comments
External Data
Subunit Structure (UniProtKB)
Consists of at least two heavy chains and a number of intermediate and light chains.
(UniProt, P37276)
Domain
Dynein heavy chains probably consist of an N-terminal stem (which binds cargo and interacts with other dynein components), and the head or motor domain. The motor contains six tandemly-linked AAA domains in the head, which form a ring. A stalk-like structure (formed by two of the coiled coil domains) protrudes between AAA 4 and AAA 5 and terminates in a microtubule-binding site. A seventh domain may also contribute to this ring; it is not clear whether the N-terminus or the C-terminus forms this extra domain. There are four well-conserved and two non-conserved ATPase sites, one per AAA domain. Probably only one of these (within AAA 1) actually hydrolyzes ATP, the others may serve a regulatory function.
(UniProt, P37276)
Linkouts
Sequences Consistent with the Gene Model
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Dhc64C using the Feature Mapper tool.

External Data
Crossreferences
Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
Linkouts
Gene Ontology (58 terms)
Molecular Function (7 terms)
Terms Based on Experimental Evidence (2 terms)
CV Term
Evidence
References
inferred from direct assay
inferred from direct assay
Terms Based on Predictions or Assertions (6 terms)
CV Term
Evidence
References
inferred from electronic annotation with InterPro:IPR011704
(assigned by InterPro )
inferred from sequence or structural similarity with UniProtKB:A8JDH8
inferred from biological aspect of ancestor with PANTHER:PTN000743491
(assigned by GO_Central )
inferred from sequence or structural similarity
inferred from biological aspect of ancestor with PANTHER:PTN000743491
(assigned by GO_Central )
inferred from sequence or structural similarity with UniProtKB:P34036
inferred from biological aspect of ancestor with PANTHER:PTN000743491
(assigned by GO_Central )
inferred from biological aspect of ancestor with PANTHER:PTN000743491
(assigned by GO_Central )
inferred from sequence or structural similarity with UniProtKB:Q14204
Biological Process (41 terms)
Terms Based on Experimental Evidence (34 terms)
CV Term
Evidence
References
inferred from mutant phenotype
inferred from mutant phenotype
inferred from mutant phenotype
inferred from mutant phenotype
inferred from mutant phenotype
inferred from mutant phenotype
inferred from mutant phenotype
(assigned by UniProt )
inferred from direct assay
inferred from mutant phenotype
inferred from mutant phenotype
inferred from mutant phenotype
inferred from mutant phenotype
inferred from mutant phenotype
inferred from mutant phenotype
inferred from mutant phenotype
inferred from mutant phenotype
inferred from mutant phenotype
inferred from mutant phenotype
inferred from mutant phenotype
(assigned by BHF-UCL )
Terms Based on Predictions or Assertions (8 terms)
CV Term
Evidence
References
inferred from biological aspect of ancestor with PANTHER:PTN000072732
(assigned by GO_Central )
traceable author statement
traceable author statement
inferred from biological aspect of ancestor with PANTHER:PTN000743491
(assigned by GO_Central )
inferred from sequence or structural similarity
inferred from biological aspect of ancestor with PANTHER:PTN000072732
(assigned by GO_Central )
Cellular Component (10 terms)
Terms Based on Experimental Evidence (8 terms)
CV Term
Evidence
References
inferred from direct assay
inferred from direct assay
inferred from direct assay
inferred from physical interaction with FLYBASE:Dlic; FB:FBgn0030276
inferred from direct assay
inferred from direct assay
Terms Based on Predictions or Assertions (3 terms)
CV Term
Evidence
References
inferred from sequence or structural similarity
inferred from sequence or structural similarity with UniProtKB:P36022
inferred from biological aspect of ancestor with PANTHER:PTN000072732
(assigned by GO_Central )
inferred from biological aspect of ancestor with PANTHER:PTN000743491
(assigned by GO_Central )
traceable author statement
Expression Data
Expression Summary Ribbons
Colored tiles in ribbon indicate that expression data has been curated by FlyBase for that anatomical location. Colorless tiles indicate that there is no curated data for that location.
For complete stage-specific expression data, view the modENCODE Development RNA-Seq section under High-Throughput Expression below.
Transcript Expression
northern blot
Stage
Tissue/Position (including subcellular localization)
Reference
Additional Descriptive Data
Dhc64C is the main dynein transcript expressed in ovaries and embryos. It is also detected in male testis.
Marker for
 
Subcellular Localization
CV Term
Polypeptide Expression
distribution deduced from reporter or direct label
Stage
Tissue/Position (including subcellular localization)
Reference
immunolocalization
Stage
Tissue/Position (including subcellular localization)
Reference
mass spectroscopy
Stage
Tissue/Position (including subcellular localization)
Reference
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Evidence
References
inferred from direct assay
inferred from direct assay
inferred from direct assay
inferred from physical interaction with FLYBASE:Dlic; FB:FBgn0030276
inferred from direct assay
inferred from direct assay
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\Dhc64C in GBrowse 2
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
Images
Alleles, Insertions, and Transgenic Constructs
Classical and Insertion Alleles ( 38 )
For All Classical and Insertion Alleles Show
 
Allele of Dhc64C
Class
Mutagen
Associated Insertion
Stocks
Known lesion
Other relevant insertions
Transgenic Constructs ( 24 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of Dhc64C
Allele of Dhc64C
Mutagen
Associated Transgenic Construct
Stocks
Transgenic constructs containing regulatory region of Dhc64C
reporter construct
Name
Expression Data
Deletions and Duplications ( 5 )
Phenotypes
For more details about a specific phenotype click on the relevant allele symbol.
Lethality
Allele
Sterility
Allele
Other Phenotypes
Allele
Phenotype manifest in
Allele
posterior fascicle & axon
Orthologs
Human Orthologs (via DIOPT v7.1)
Homo sapiens (Human) (17)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Alignment
Complementation?
Transgene?
15 of 15
Yes
Yes
2 of 15
No
No
2 of 15
No
No
2 of 15
No
No
2 of 15
No
No
2 of 15
No
No
2 of 15
No
No
2 of 15
No
No
2 of 15
No
No
2 of 15
No
No
2 of 15
No
No
2 of 15
No
No
2 of 15
No
No
2 of 15
No
No
1 of 15
No
No
1 of 15
No
Yes
1 of 15
No
No
Model Organism Orthologs (via DIOPT v7.1)
Mus musculus (laboratory mouse) (16)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Alignment
Complementation?
Transgene?
14 of 15
Yes
Yes
2 of 15
No
No
2 of 15
No
No
2 of 15
No
No
2 of 15
No
No
2 of 15
No
No
2 of 15
No
No
2 of 15
No
No
2 of 15
No
No
2 of 15
No
No
2 of 15
No
No
2 of 15
No
No
2 of 15
No
No
1 of 15
No
No
1 of 15
No
No
1 of 15
No
Yes
Rattus norvegicus (Norway rat) (8)
11 of 13
Yes
Yes
2 of 13
No
No
2 of 13
No
No
1 of 13
No
No
1 of 13
No
No
1 of 13
No
No
1 of 13
No
No
1 of 13
No
No
Xenopus tropicalis (Western clawed frog) (3)
1 of 12
Yes
No
1 of 12
Yes
No
1 of 12
Yes
No
Danio rerio (Zebrafish) (11)
9 of 15
Yes
Yes
2 of 15
No
No
2 of 15
No
No
2 of 15
No
No
2 of 15
No
No
2 of 15
No
No
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
Caenorhabditis elegans (Nematode, roundworm) (3)
14 of 15
Yes
Yes
2 of 15
No
No
1 of 15
No
Yes
Arabidopsis thaliana (thale-cress) (0)
No orthologs reported.
Saccharomyces cerevisiae (Brewer's yeast) (1)
12 of 15
Yes
Yes
Schizosaccharomyces pombe (Fission yeast) (1)
9 of 12
Yes
Yes
Orthologs in Drosophila Species (via OrthoDB v9.1) ( EOG0919000J )
Organism
Common Name
Gene
AAA Syntenic Ortholog
Multiple Dmel Genes in this Orthologous Group
Drosophila melanogaster
fruit fly
Drosophila suzukii
Spotted wing Drosophila
Drosophila simulans
Drosophila sechellia
Drosophila erecta
Drosophila yakuba
Drosophila ananassae
Drosophila pseudoobscura pseudoobscura
Drosophila persimilis
Drosophila willistoni
Drosophila virilis
Drosophila mojavensis
Drosophila grimshawi
Orthologs in non-Drosophila Dipterans (via OrthoDB v9.1) ( EOG0915000E )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Musca domestica
House fly
Glossina morsitans
Tsetse fly
Lucilia cuprina
Australian sheep blowfly
Mayetiola destructor
Hessian fly
Aedes aegypti
Yellow fever mosquito
Anopheles darlingi
American malaria mosquito
Anopheles gambiae
Malaria mosquito
Culex quinquefasciatus
Southern house mosquito
Orthologs in non-Dipteran Insects (via OrthoDB v9.1) ( EOG090W00D5 )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Bombyx mori
Silkmoth
Danaus plexippus
Monarch butterfly
Heliconius melpomene
Postman butterfly
Apis florea
Little honeybee
Apis florea
Little honeybee
Apis mellifera
Western honey bee
Apis mellifera
Western honey bee
Bombus impatiens
Common eastern bumble bee
Bombus terrestris
Buff-tailed bumblebee
Linepithema humile
Argentine ant
Megachile rotundata
Alfalfa leafcutting bee
Nasonia vitripennis
Parasitic wasp
Nasonia vitripennis
Parasitic wasp
Nasonia vitripennis
Parasitic wasp
Nasonia vitripennis
Parasitic wasp
Nasonia vitripennis
Parasitic wasp
Nasonia vitripennis
Parasitic wasp
Dendroctonus ponderosae
Mountain pine beetle
Tribolium castaneum
Red flour beetle
Pediculus humanus
Human body louse
Rhodnius prolixus
Kissing bug
Cimex lectularius
Bed bug
Acyrthosiphon pisum
Pea aphid
Zootermopsis nevadensis
Nevada dampwood termite
Orthologs in non-Insect Arthropods (via OrthoDB v9.1) ( EOG090X00CC )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strigamia maritima
European centipede
Ixodes scapularis
Black-legged tick
Ixodes scapularis
Black-legged tick
Stegodyphus mimosarum
African social velvet spider
Stegodyphus mimosarum
African social velvet spider
Stegodyphus mimosarum
African social velvet spider
Tetranychus urticae
Two-spotted spider mite
Daphnia pulex
Water flea
Orthologs in non-Arthropod Metazoa (via OrthoDB v9.1) ( EOG091G00JH )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strongylocentrotus purpuratus
Purple sea urchin
Strongylocentrotus purpuratus
Purple sea urchin
Strongylocentrotus purpuratus
Purple sea urchin
Strongylocentrotus purpuratus
Purple sea urchin
Strongylocentrotus purpuratus
Purple sea urchin
Strongylocentrotus purpuratus
Purple sea urchin
Ciona intestinalis
Vase tunicate
Ciona intestinalis
Vase tunicate
Gallus gallus
Domestic chicken
Human Disease Model Data
FlyBase Human Disease Model Reports
    Alleles Reported to Model Human Disease (Disease Ontology)
    Download
    Models ( 1 )
    Allele
    Disease
    Evidence
    References
    inferred from mutant phenotype
    Interactions ( 3 )
    Comments ( 0 )
     
    Human Orthologs (via DIOPT v7.1)
    Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
    Functional Complementation Data
    Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
    Interactions
    Summary of Physical Interactions
    esyN Network Diagram
    Show neighbor-neighbor interactions:
    Select Layout:
    Legend:
    Protein
    RNA
    Selected Interactor(s)
    Interactions Browser

    Please look at the Interaction Group reports for full details of the physical interactions
    protein-protein
    Interacting group
    Assay
    References
    RNA-protein
    Interacting group
    Assay
    References
    Summary of Genetic Interactions
    esyN Network Diagram
    esyN Network Key:
    Suppression
    Enhancement

    Please look at the allele data for full details of the genetic interactions
    Starting gene(s)
    Interaction type
    Interacting gene(s)
    Reference
    Starting gene(s)
    Interaction type
    Interacting gene(s)
    Reference
    External Data
    Subunit Structure (UniProtKB)
    Consists of at least two heavy chains and a number of intermediate and light chains.
    (UniProt, P37276 )
    Linkouts
    DroID - A comprehensive database of gene and protein interactions.
    InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.
    Pathways
    Gene Group - Pathway Membership (FlyBase)
    External Data
    Linkouts
    KEGG Pathways - Wiring diagrams of molecular interactions, reactions and relations.
    Genomic Location and Detailed Mapping Data
    Chromosome (arm)
    3L
    Recombination map
    3-12
    Cytogenetic map
    Sequence location
    3L:4,807,368..4,825,687 [-]
    FlyBase Computed Cytological Location
    Cytogenetic map
    Evidence for location
    64B17-64C1
    Limits computationally determined from genome sequence between P{PZ}l(3)rG166rG166 and P{PZ}sinu06524
    Experimentally Determined Cytological Location
    Cytogenetic map
    Notes
    References
    64C-64C
    (determined by in situ hybridisation)
    Experimentally Determined Recombination Data
    Notes
    Stocks and Reagents
    Stocks (17)
    Genomic Clones (21)
    cDNA Clones (23)
     

    Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

    cDNA clones, fully sequences
    BDGP DGC clones
    Other clones
    Drosophila Genomics Resource Center cDNA clones

    For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

    cDNA Clones, End Sequenced (ESTs)
    RNAi and Array Information
    Linkouts
    DRSC - Results frm RNAi screens
    GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
    Antibody Information
    Laboratory Generated Antibodies
     
    polyclonal
    Commercially Available Antibodies
     
    Developmental Studies Hybridoma Bank - Monoclonal antibodies for use in research
    Other Information
    Relationship to Other Genes
    Source for database identify of
    Source for database merge of
    Source for merge of: Dhc64C Laborc
    Source for merge of: Dhc64C Su(Gl)77
    Additional comments
    Allelism between Su(Gl)77, Su(Gl)102 and Su(Gl)160 has not been established. These are independent mutations with suppressing effects on Gl which all map between ru and h on the third chromosome.
    Other Comments
    Dhc64C is required for the rapid transport of grk, bcd AND osk RNAs from nurse cells to the oocyte by a mechanism distinct from the general flow of cytoplasm from nurse cells to oocyte.
    RNAi screen using dsRNA made from templates generated with primers directed against this gene causes spindle pole detachment when assayed in S2 cells. This phenotype can be observed when the screen is performed with or without Cdc27 dsRNA.
    dsRNA has been synthesised for this gene and transfected into S2 cells. S2 cells treated with this dsRNA arrest in metaphase, require 50% more time to form a metaphase plate than untreated cells and exhibit centrosome detachment and spindle focusing defects.
    Dhc64C activity is required to maintain localisation of bcd at the anterior cortex.
    Dhc64C is required to maintain mRNA at its apical localization, following transport, in the blastoderm embryo.
    S2 cells transfected with dsRNA made from templates generated with primers directed against this gene causes detachment of centrosomes from the spindle poles, resulting in a slight increase of spindle size.
    Mitotic S2 cells treated with dsRNA made from templates generated with primers directed against this gene display a striking detachment of centrosomes from spindles and a loss of spindle pole focusing, resulting in an increase in pole-pole spacing. There is also an increase in spindle length and an elevation of the mitotic index.
    dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R+ cell morphology.
    Dhc64C may be involved in the prevention of centrosome assembly in unfertilised eggs, and establishing harmony between the chromosome and centrosome cycles.
    Spindle pole movements in embryos are directed by a temporally coordinated balance of forces generated by three mitotic motors; cytoplasmic dynein, Klp61F and ncd. Dynein acts to move the poles apart throughout mitosis, and this activity is augmented by Klp61F after the fenestration of the nuclear envelope, which occurs at the onset of prometaphase. ncd generates forces that pull the poles together between interphase and metaphase, antagonising the activity of both cytoplasmic dynein and Klp61F and serving as a brake for spindle assembly.
    Mutations in Dhc64C disrupt fast organelle transport in both directions in axons.
    Dhc64C function is required for the attachment and migration of centrosomes along the nuclear envelope during interphase/prophase and to maintain the attachment of centrosomes to mitotic spindle poles.
    Identification: PCR screen for Dynein heavy chain genes.
    Mutant analysis of Dhc64C reveals cytoplasmic dynein is required at two stages of oogenesis. The localisation of dynein in mitotic cysts suggests spindle orientation is mediated by the microtubule motor cytoplasmic dynein. Later in oogenesis dynein function is necessary for proper differentiation.
    Early in oogenesis mutations disrupt spindle organisation in dividing cysts and block oocyte determination.
    Cytoplasmic dynein encoded by Dhc64C is essential for Drosophila viability and for cell viability in several tissues.
    Clonal analysis suggests that cytoplasmic dynein mutations are cell lethal, and maternal supplies are sufficient for development to larval stages.
    Cytoplasmic dynein is required for the proper formation of the oocyte early in oogenesis. Later, during oocyte growth, dynein is required for the transport of materials from the nurse cells to the developing oocyte.
    Dhc64C protein acts as a minus-end directed motor that promotes microtubule translocation in vitro.
    Dhc64C encodes a cytoplasmic dynein heavy chain polypeptide.
    Dhc64C has been cloned and characterised.
    Origin and Etymology
    Discoverer
    Etymology
    Mutation is named after a Hungarian clan that vanished by the beginning of the 14th century but their names survived in the names of settlements.
    "Laborc" named for a Hungarian family that vanished by the beginning of the 14th century.
    Identification
    External Crossreferences and Linkouts ( 74 )
    Sequence Crossreferences
    NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
    GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
    GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
    RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
    UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information
    UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information
    Linkouts
    Drosophila Genomics Resource Center - Drosophila Genomics Resource Center cDNA clones
    DroID - A comprehensive database of gene and protein interactions.
    DRSC - Results frm RNAi screens
    Developmental Studies Hybridoma Bank - Monoclonal antibodies for use in research
    Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
    Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
    FlyMine - An integrated database for Drosophila genomics
    GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
    Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution
    InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.
    KEGG Genes - Molecular building blocks of life in the genomic space.
    KEGG Pathways - Wiring diagrams of molecular interactions, reactions and relations.
    MIST (genetic) - An integrated Molecular Interaction Database
    MIST (protein-protein) - An integrated Molecular Interaction Database
    modMine - A data warehouse for the modENCODE project
    Synonyms and Secondary IDs (46)
    Reported As
    Symbol Synonym
    Fs(3)Sz18
    l(3)64Ca
    Name Synonyms
    Cytoplasmic dynein
    Cytoplasmic dynein heavy chain
    Dynein Heavy Chain
    Dynein heavy chain 64c
    Dynein heavy-chain
    Female sterile(3)Laborc
    Suppressor of Glued 77
    cytoplasmic Dynein heavy chain
    cytoplasmic dynenin
    dynein heavy chain at 64C
    dynein heavy-chain
    Secondary FlyBase IDs
    • FBgn0010349
    • FBgn0001059
    • FBgn0003565
    Datasets (0)
    Study focus (0)
    Experimental Role
    Project
    Project Type
    Title
    References (337)