FlyBase Gene Report: Dmel\CG42750

General Information

Symbol

Dmel\CG42750

Species

D. melanogaster

Name

Annotation Symbol

CG42750

Feature Type

protein_coding_gene

FlyBase ID

FBgn0261804

Gene Model Status

Current

Stock Availability

14 publicly available

Gene Summary

Contribute a Gene Snapshot for this gene.

All Summaries

Alliance
Auto summary
Gene Group
Interactive Fly

Key Links

Genomic Location

Cytogenetic map

36E6-36F2

Sequence location

2L:18,159,811..18,275,770 [-]

Recombination map

2-53

RefSeq locus

NT_033779 REGION:18159811..18275770

Sequence

Get Decorated FASTA

Genomic Maps

JBrowse

Other Genome Views

The following external sites may use different assemblies or annotations than FlyBase.

Function

Gene Ontology (GO) Annotations (2 terms)

Molecular Function (1 term)

Terms Based on Experimental Evidence (0 terms)

Terms Based on Predictions or Assertions (1 term)

CV Term

Evidence

References

enables metallodipeptidase activity

inferred from electronic annotation with InterPro:IPR000180, InterPro:IPR008257

(InterPro Project Members, 2004-)

Biological Process (1 term)

Terms Based on Experimental Evidence (0 terms)

Terms Based on Predictions or Assertions (1 term)

CV Term

Evidence

References

involved_in proteolysis

inferred from electronic annotation with InterPro:IPR000180, InterPro:IPR008257

(InterPro Project Members, 2004-)

Cellular Component (0 terms)

Terms Based on Experimental Evidence (0 terms)

Terms Based on Predictions or Assertions (0 terms)

Gene Group (FlyBase)

M19 METALLODIPEPTIDASES

Protein Family (UniProt)

Protein Signatures (InterPro)

Summaries

Gene Group (FlyBase)

M19 METALLODIPEPTIDASES -: M19 metallodipeptidases belong to MEROPS family M19. These enzymes cleave both dipeptides and beta-lactams. (Adapted from FBrf0239469.)

Gene Model and Products

Number of Transcripts

Number of Unique Polypeptides

Please see the JBrowse view of Dmel\CG42750 for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)

Isoform displayed:

Pfam protein domains

InterPro name

classification

start

end

Protein Domains (via SMART)

Isoform displayed:

SMART protein domains

InterPro name

classification

start

end

Structure

Protein 3D structure (Predicted by AlphaFold) (AlphaFold entry Q9VJ94)

If you don't see a structure in the viewer, refresh your browser.

Model Confidence:

Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Experimentally Determined Structures

Crossreferences

Comments on Gene Model

Gene model reviewed during 5.52

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Assoc. CDS (aa)

CG42750-RB

FBtr0303280

NM_165245

6066

1068

CG42750-RC

FBtr0343817

NM_001299103

6913

1067

Additional Transcript Data and Comments

Reported size (kB)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kDa)

Length (aa)

Theoretical pI

UniProt

RefSeq ID

GenBank

CG42750-PB

FBpp0292372

116.0

1068

8.32

FBpp0310369

115.9

1067

8.32

X2JA84

NP_001286032

AHN54546

Polypeptides with Identical Sequences

None of the polypeptides share 100% sequence identity.

Additional Polypeptide Data and Comments

Reported size (kDa)

Comments

External Data

Crossreferences

InterPro - A database of protein families, domains and functional sites

Linkouts

Sequences Consistent with the Gene Model

Nucleotide / Polypeptide Records

UniProt

Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\CG42750 using the Feature Mapper tool.

External Data

Crossreferences

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

CG42750_1

Linkouts

Expression Data

Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

-0.56

Transcript Expression

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Polypeptide Expression

mass spectroscopy

Stage

Tissue/Position (including subcellular localization)

Reference

adult stage

adult head

• membrane

(Aradska et al., 2015)

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Evidence

References

Expression Deduced from Reporters

High-Throughput Expression Data

Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\CG42750 in JBrowse

RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region

View exonic expression by developmental stage for Dmel\CG42750

View exonic expression by tissue for Dmel\CG42750

Bulk Downloads

RNA-Seq RPKM values for all genes

Reference

See Gelbart and Emmert, 2013 for analysis details and data files for all genes.

Developmental Proteome: Life Cycle

Developmental Proteome: Embryogenesis

External Data and Images

Linkouts

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

35090/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0261804

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0261804

Flygut - An atlas of the Drosophila adult midgut

FBgn0261804

Images

FlyBase Wiki

Image Based Resources

Alleles, Insertions, Transgenic Constructs, and Aberrations

Classical and Insertion Alleles ( 8 )

For All Classical and Insertion Alleles Show

Other relevant insertions

Transgenic Constructs ( 8 )

For All Alleles Carried on Transgenic Constructs Show

Transgenic constructs containing/affecting coding region of CG42750

Transgenic constructs containing regulatory region of CG42750

Aberrations (Deficiencies and Duplications) ( 1 )

Inferred from experimentation ( 1 )

Gene disrupted in

Df(2L)Exel8038

(Ryder, 2004.4.26)

Inferred from location ( 6 )

Variants

Variant Molecular Consequences

Alleles Representing Disease-Implicated Variants

Phenotypes

For more details about a specific phenotype click on the relevant allele symbol.

Lethality

Allele

viable

CG42750^f03296

viable, with Dcr-2^UAS.cDa, Scer\GAL4^elav.PLu

viable, with Scer\GAL4^Mef2.PR

viable, with Scer\GAL4^pnr-MD237

viable, with Scer\GAL4^tin.CΔ4

CG42750^GD13479

Sterility

Allele

fertile

CG42750^f03296

Other Phenotypes

Allele

visible, with Scer\GAL4^pnr-MD237

CG42750^GD10366

Phenotype manifest in

Allele

trichogen cell, with Scer\GAL4^pnr-MD237

CG42750^GD10366

Orthologs

Downloads

Download All DIOPT Orthologs

Human Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Homo sapiens (Human) (6)

Hsap\DPEP2

10 of 14

Yes

8 of 14

8 of 14

1 of 14

1 of 14

1 of 14

Model Organism Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Rattus norvegicus (Norway rat) (5)

Rnor\Dpep2

10 of 14

Yes

8 of 14

8 of 14

1 of 14

1 of 14

Mus musculus (laboratory mouse) (6)

Mmus\Dpep2

9 of 14

Yes

8 of 14

8 of 14

1 of 14

1 of 14

1 of 14

Xenopus tropicalis (Western clawed frog) (2)

Xtro\dpep2

8 of 13

Yes

Xtro\dpep1

6 of 13

Danio rerio (Zebrafish) (4)

Drer\dpep1

9 of 14

Yes

Drer\dpep2

7 of 14

Drer\cetn3

1 of 14

Drer\cetn4

1 of 14

Caenorhabditis elegans (Nematode, roundworm) (1)

Cele\R08D7.5

1 of 14

Yes

Anopheles gambiae (African malaria mosquito) (6)

Agam\AgaP_AGAP007854

8 of 12

Yes

5 of 12

5 of 12

5 of 12

3 of 12

1 of 12

Arabidopsis thaliana (thale-cress) (5)

Atha\AT2G46600

1 of 13

Yes

Atha\AT4G27280

1 of 13

Yes

Atha\CEN2

1 of 13

Yes

Atha\CEN2

1 of 13

Yes

Atha\PBP1

1 of 13

Yes

Saccharomyces cerevisiae (Brewer's yeast) (1)

Scer\CDC31

1 of 13

Yes

Schizosaccharomyces pombe (Fission yeast) (3)

Spom\SPCC965.12

8 of 12

Yes

Spom\SPAC3A11.10c

7 of 12

Spom\cdc31

1 of 12

Escherichia coli (enterobacterium) (0)

Other Organism Orthologs (via OrthoDB)

Data provided directly from OrthoDB:CG42750. Refer to their site for version information.

Paralogs

Downloads

Download All DIOPT Paralogs

Paralogs (via DIOPT v9.1)

Gene Symbol

Score

Source

Alignment

Drosophila melanogaster (Fruit fly) (5)

9 of 13

7 of 13

4 of 13

1 of 13

1 of 13

Human Disease Associations

FlyBase Human Disease Model Reports

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Allele

Disease

Evidence

References

Potential Models Based on Orthology ( 0 )

Human Ortholog

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Allele

Disease

Interaction

References

Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)

Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.

Homo sapiens (Human)

Gene name

Score

OMIM

OMIM Phenotype

DO term

Complementation?

Transgene?

10 of 14

8 of 14

8 of 14

Functional Complementation Data

Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.

Interactions

Summary of Physical Interactions

esyN Network Diagram

Other Interaction Browsers

Summary of Genetic Interactions

esyN Network Diagram

Other Interaction Browsers

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

External Data

Linkouts

DroID - A comprehensive database of gene and protein interactions.

FBgn0261804

Pathways

Signaling Pathways (FlyBase)

Metabolic Pathways

FlyBase

External Links

Reactome Metabolic Pathways - An open-source, open access, manually curated and peer-reviewed metabolic pathway database.

External Data

Linkouts

Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.

Class of Gene

nuclear_gene

protein_coding_gene

Genomic Location and Detailed Mapping Data

Chromosome (arm)

Recombination map

2-53

Cytogenetic map

36E6-36F2

Sequence location

2L:18,159,811..18,275,770 [-]

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

36E6-36F2

Limits computationally determined from genome sequence between P{lacW}Aac11^k06710 and P{EP}CG10413^EP2164;

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

Experimentally Determined Recombination Data

Location

2-53

(FlyBase, 2016)

2-53.3

(Comeron et al., 2012)

Left of (cM)

Right of (cM)

Notes

Stocks and Reagents

Stocks (14)

Aberrations including deletions of this gene Aberrations including duplications of this gene

Bloomington

18637

w¹¹¹⁸; PBac{WH}CG42750^f03296

62804

w¹¹¹⁸; PBac{IT.GAL4}CG42750^0363-G4

43058

y¹ w^*; Mi{MIC}CG42750^MI06374

44815

y¹ w^*; Mi{MIC}CG42750^MI08755

55578

y¹ w^*; Mi{MIC}CG42750^MI11037

23074

y¹ w^67c23; Mi{ET1}CG42750^MB01359

37866

y¹ w^*; Mi{MIC}CG42750^MI04904/CyO

66804

y¹ w^*; Mi{Trojan-GAL4.0}CG42750^{MI06374-TG4.0}

31746R-2

31786R-1

v102258

v104049

More stocks available...

Genomic Clones (77)

Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

cDNA Clones (8)

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequenced

BDGP DGC clones

IP09988

Other clones

Drosophila Genomics Resource Center cDNA clones

For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

FBgn0261804

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

Other clones

RNAi and Array Information

Linkouts

DRSC - Results frm RNAi screens

FBgn0261804

Antibody Information

Laboratory Generated Antibodies

Commercially Available Antibodies

Cell Line Information

Publicly Available Cell Lines

Other Stable Cell Lines

Other Comments

RNAi generated by PCR using primers directed to this gene causes a cell growth and viability phenotype when assayed in Kc167 and S2R⁺ cells.

(Boutros et al., 2004)

dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R⁺ cell morphology.

(Kiger et al., 2003)

Relationship to Other Genes

Source for database merge of

Source for merge of: CG31746 CG15157

(FlyBase Genome Annotators, 2008)

Source for merge of: CG31786 CG42400

(FlyBase Genome Annotators, 2010)

Source for merge of: CG7167 CG7198

(FlyBase Genome Annotators, 2002-2003)

Additional comments

Annotations CG31786 and CG42400 merged as CG42750 in release 5.28 of the genome annotation.

(FlyBase Genome Annotators, 2010)

Annotations CG31746 and CG15157 merged as CG42400 in release 5.10 of the genome annotation.

(FlyBase Genome Annotators, 2008)

Annotation CG15158 split into CG31786 and CG31802 in release 3 of the genome annotation.

(FlyBase Genome Annotators, 2002-2003)

Annotations CG7167 and CG7198 merged as CG31746 in release 3 of the genome annotation.

(FlyBase Genome Annotators, 2002-2003)

Nomenclature History

Source for database identify of

Nomenclature comments

Etymology

Synonyms and Secondary IDs (8)

Reported As

Symbol Synonym

CG15157

(Keleman et al., 2009.8.5, Lawniczak and Begun, 2004)

CG15158

(Solano et al., 2003, Goldstein and Gunawardena, 2000)

CG31746

(Japanese National Institute of Genetics, 2012.5.21, Keleman et al., 2009.8.5, Geng and MacDonald, 2007)

CG31786

(Ashwal-Fluss et al., 2014, Japanese National Institute of Genetics, 2012.5.21)

CG42400

(Ashwal-Fluss et al., 2014, FlyBase Genome Annotators, 2008)

CG42750

(National Institute of Genetics Fly Stocks, 2022-, Huang et al., 2020, Meltzer et al., 2019, Croset et al., 2018, Clandinin and Owens, 2016-, Gene Disruption Project members, 2016-, Hosono et al., 2015, FlyBase Genome Annotators, 2010)

CG7167

CG7198

Name Synonyms

CG15157

CG31746

Secondary FlyBase IDs

FBgn0051786
FBgn0032676
FBgn0259819
FBgn0051746
FBgn0032672
FBgn0032674
FBgn0032675
CG31746
CG15157

Datasets (0)

Study focus (0)

Experimental Role

Project

Project Type

Title

Study result (0)

Result

Result Type

Title

External Crossreferences and Linkouts ( 34 )

Sequence Crossreferences

NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.

35090

GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.

BI641839

GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.

RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.

UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.

Q9VJ94

UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information

Other crossreferences

AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.

Q9VJ94

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

35090/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0261804

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0261804

InterPro - A database of protein families, domains and functional sites

KEGG Genes - Molecular building blocks of life in the genomic space.

dme:Dmel_CG42750

MARRVEL_MODEL - MARRVEL (model organism gene)

35090

Linkouts

Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones

FBgn0261804

DroID - A comprehensive database of gene and protein interactions.

FBgn0261804

DRSC - Results frm RNAi screens

FBgn0261804

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

CG42750_1

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FlyCyc Genes - Genes from a BioCyc PGDB for Dmel

FBGN0261804

Flygut - An atlas of the Drosophila adult midgut

FBgn0261804

FlyMet - A comprehensive tissue-specific metabolomics resource for Drosophila.

FBgn0261804

Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.

Reactome Metabolic Pathways - An open-source, open access, manually curated and peer-reviewed metabolic pathway database.

References (51)

The following external sites may use different assemblies or annotations than FlyBase.

-0.56

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