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Gene Dmel\Bsg

General Information
Symbol	Dmel\Bsg	Species	D. melanogaster
Name	Basigin	Annotation symbol	CG31605
Feature type	protein_coding_gene	FlyBase ID	FBgn0261822
Gene Model Status	Current	Stock availability	25 publicly available
Also Known As	gel, l(2)06243, l(2)k13638
Genomic Location
Chromosome (arm)	2L	Recombination map
Cytogenetic map	28E3-28E5	Sequence location	2L:8,083,422..8,110,561 [+]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents modENCODE GBrowse	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene Basigin is referred to in FlyBase by the symbol Dmel\Bsg (CG31605, FBgn0261822). It is a protein_coding_gene from Drosophila melanogaster. Its molecular function is unknown. There is experimental evidence that it is involved in the biological process: inter-male aggressive behavior; spermatid development; mitochondrion localization; cell-cell adhesion; sarcomere organization; photoreceptor cell morphogenesis; endoplasmic reticulum localization; nucleus localization. 73 alleles are reported. The phenotypes of these alleles are annotated with: Z disc; NMJ bouton; epithelial glial cell; photoreceptor cell; mesothoracic tergum; wing; nucleus; synaptic vesicle; crystal cell. It has 9 annotated transcripts and 9 annotated polypeptides. Protein features are: Immunoglobulin I-set; Immunoglobulin subtype; Immunoglobulin subtype 2; Immunoglobulin-like; Immunoglobulin-like fold. Gene sequence location is 2L:8083422..8110561.
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2012_01	Insertions Mi{MIC}Bsg[MI03588] References Bellen, 2011.10.25, set956.xml Alleles Bsg[MI03588] Sequence features HFA01011 BKN28920 HFA01010
FB2011_10	References Knowles-Barley, 2011.8.24, BrainTrap expression curation. Controlled Vocabulary Terms day 42 of adulthood day 41 of adulthood day 30 of adulthood day 49 of adulthood day 17 of adulthood day 45 of adulthood day 8 of adulthood day 26 of adulthood day 21 of adulthood day 13 of adulthood day 25 of adulthood day 22 of adulthood day 20 of adulthood day 39 of adulthood day 7 of adulthood day 36 of adulthood day 11 of adulthood day 37 of adulthood day 27 of adulthood day 18 of adulthood day 19 of adulthood day 28 of adulthood day 9 of adulthood day 29 of adulthood adult heart day 40 of adulthood day 16 of adulthood day 24 of adulthood day 15 of adulthood day 33 of adulthood day 43 of adulthood day 47 of adulthood day 38 of adulthood day 32 of adulthood day 48 of adulthood day 23 of adulthood day 35 of adulthood day 12 of adulthood day 10 of adulthood day 31 of adulthood day 34 of adulthood day 44 of adulthood day 14 of adulthood day 46 of adulthood
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 28E3-28E5   Limits computationally determined from genome sequence between P{EP}poeEP737 and P{lacW}l(2)k16919k16919&P{lacW}Bsgk09030; Left limit from in situ hybridisation (FBrf0157097) Right limit from in situ hybridisation (FBrf0157097)
Experimentally Determined Cytological Location
Cytogenetic map Notes References 28D-28D   (determined by in situ hybridisation)   (Weber, 2005) 28E4-28E5     (Oh et al., 2003) 28E3-28E4   (determined by in situ hybridisation)   (Spradling et al., 1999) 28D1-28D12   28D3--4 28E3--4 28E4--5   (BDGP Project Members, 1994-1999)
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\Bsg for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) Bsg-RA FBtr0079567  NM_164782   2857   265 Bsg-RB FBtr0079566  NM_164783   2742   265 Bsg-RC FBtr0079569  NM_164784   3066   265 Bsg-RD FBtr0079568  NM_164785   2951   265 Bsg-RE FBtr0079570  NM_164786   2790   265 Bsg-RF FBtr0079571  NM_164787   3095   265 Bsg-RG FBtr0079574  NM_164790   2418   648 Bsg-RH FBtr0079572  NM_164788   2999   265 Bsg-RI FBtr0079573  NM_164789   2827   265
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein Bsg-PA   FBpp0079189   29.2   265   4.79     NP_723338   AAN10653 Bsg-PB   FBpp0079188   29.2   265   4.79     NP_723339   AAN10654 Bsg-PC   FBpp0079191   29.2   265   4.79     NP_723340   AAN10655 Bsg-PD   FBpp0079190   29.2   265   4.79     NP_723341   AAN10656 Bsg-PE   FBpp0079192   29.2   265   4.79     NP_723342   AAN10657 Bsg-PF   FBpp0079193   29.2   265   4.79     NP_723343   AAN10658 Bsg-PG   FBpp0079196   70.5   648   6.89     NP_723346   AAN10661 Bsg-PH   FBpp0079194   29.2   265   4.79     NP_723344   AAN10659 Bsg-PI   FBpp0079195   29.2   265   4.79     NP_723345   AAN10660
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Immunoglobulin subtype 2 (IPR003598) Immunoglobulin subtype (IPR003599) Immunoglobulin-like (IPR007110) Immunoglobulin-like fold (IPR013783) Immunoglobulin I-set (IPR013098)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA141423   AA246956   AA391684   AA391925   AA392352   AA392826   AA438534   AA439007   AA440085   AA440287   AA540081   AA695150   AA695525   AA695969   AA696031   AA802624   AA802626   AA803388   AA820055   AE014134 AAN10653   AE014134 AAN10654   AE014134 AAN10655   AE014134 AAN10656   AE014134 AAN10657   AE014134 AAN10658   AE014134 AAN10659   AE014134 AAN10660   AE014134 AAN10661   AB082425   AI238192   AI257738   AI259402   AI402604   AI546593   AQ025647   AQ025790   AQ025881   AQ026062   AQ026419   AQ026466   AW940836   AW942532   AY051571 AAK92995   BG637981   BG640360   BI163899   BI164849   BI165076   BI167397   BI172264   BI212308   BI215657   BI216219   BI228620   BI229101   BI229106   BI229170   BI229213   BI229276   BI229450   BI229660   BI232986   BI233024   BI235115   BI239555   BI239780   BI240681   BI241983   BI352762   BI356105   BI356875   BI357594   BI358138   BI366440   BI370065   BI371400   BI371497   BI372407   BI373307   BI375687   BI376006   BI482144   BI483173   BI486049   BI486399   BI486962   BI487038   BI580920   BP546157   BP554399   BP558512   BT005198 AAO61755   BT006333   BT029561   BT081379   CA806769   CA807033   CL844323   CO153287   CO156798   CO177794   CO179160   CO183206   CO186022   CO186716   CO190309   CO192334   CO193429   CO193903   CO196143   CO261978   CO267276   CO270508   CO270676   CO272110   CO273766   CO277049   CO282326   CO283243   CO288126   CO288141   CO288657   CO288856   CO295328   CO297001   CO297647   CO299092   CO305320   CO305343   CO306338   CO306849   CO306961   CO308025   CO311025   CO313166   CO313295   CO313342   CO314447   CO314813   CO315809   CO318389   CO319157   CO319653   CO326246   CO330273   CO330643   CO332293   CO333146   CO333945   CO342107   CZ466591   CZ472776   CZ472777   CZ473533   CZ473534   CZ475188   CZ476037   CZ483810   CZ483811   CZ484518   CZ484519   CZ484607   CZ487277   DN154502   EC058642   EC065474   EC066425   EC068895   EC073177   EC074192   EC077733   EC078499   EC078917   EC078967   EC079425   EC080176   EC081582   EC081609   EC081638   EC082323   EC084655   EC085008   EC085344   EC087298   EC088311   EC088767   EC089058   EC194662   EC196179   EC197741   EC198069   EC198974   EC208737   EC209204   EC212997   EC213944   EC214648   EC215609   EC218262   EC225185   EC225615   EC225890   EC227164   EC227422   EC228193   EC230297   EC233447   EC240068   EC241118   EC242857   EC244199   EC245339   EC248761   EC250113   EC260084   EC261041   EC264532   EC264901   EL885557   EL885787   ES688749   ES688754   ES688762   ES688763   ES688766   ES688776   ES688781   ES688794   ES688798   ES688815   ES688818   ES688826   ES688827   ES688836   ES688841   ES688844   ES688850   ES688855   ES688860   ES688867   ES688890   ES688894   ES688895   ES688904   ES688906   ES688907   ES688930   ES688933   ES688937   ES688941   ES688947   ES688948   ES688957   ES688960   ES688962   ES688964   ES688970   ES688972   ES688975   ES688982   ES688983   ES688985   ES688990   ES689004   ES689009   ES689012   ES689019   ES689024   ES689027   ES689030   ES689042   ES689043   ES689048   ES689058   ES689070   ES689071   ES689074   ES689081   ES689084   ES689087   ES689101   ES689110   ES689117   ES689120   ES689131   ES689143   ES689163   ES689168   ES689171   ES689187   ES689191   ES689192   ES689197   ES689198   ES689567   ES689590   ES689612   ES689616   ES689620   ES689631   ES689638   ES689640   ES689642   ES689649   ES689651   ES689664   ES689666   ES689670   ES689673   ES689682   ES689684   ES689706   ES689711   ES689714   ES689716   ES689719   ES689728   ES689732   ES689751   ES689752   ES689762   ES689763   ES689766   ES689769   ES689771   ES689783   ES689788   ES689790   ES689793   ES689795   ES689798   ES689800   ES689818   ES689821   ES689830   ES689831   ES689833   ES689836   ES692724   ES693560   ES693577   ES693585   ES693589   ES693591   ES693592   ES693593   ES693594   ES693595   ES693603   ES693608   ES693609   ES693613   ES693616   ES693617   ES693622   ES693627   ES693641   ES693647   ES693650   ES694130   ES694138   ES694141   ES694146   ES694159   ES694181   ES694183   ES694194   ES694198   ES695472   EV579804   EV583270   EV588134   EV590952   EV595485   EV597846
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL	Q8IPG9 Q961I4 Q7KTJ7
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
Polypeptide Expression
mass spectroscopy Stage Tissue/Position (including subcellular localization) Reference day 7 of adulthood -- day 49 of adulthood   adult heart   (Cammarato et al., 2011)
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
High-Throughput Expression Data
or
See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes. modENCODE Temporal Expression Data (Graveley et al., 2011) FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010) mE2_34_mRNA_expression_cluster_25
External Data & Images
Linkouts
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele lethal | embryonic stage | recessive Bsgex64 Bsgδ265 lethal | larval stage | recessive Bsg06243 Bsgk13638 lethal | partially | recessive BsgNP6293 lethal | recessive Bsg1217 Bsg06243 Bsgk04604 Bsgk06338 Bsgk07602 Bsgk09030 Bsgk09402 Bsgk09412 Bsgk13510 Bsgk13638 Bsgk14308 semi-lethal | larval stage (with Df(2L)Exel7034) Bsg1217 Bsgk13638 Bsgk14308 BsgNP3198 BsgNP6293 semi-lethal | late embryonic stage (with Df(2L)Exel7034) Bsg1217 Bsgk13638 Bsgk14308 BsgNP3198 BsgNP6293 viable BsgCA06978 BsgEY10523 BsgW16 viable, with Scer\GAL4pnr-MD237 BsgGD989 BsgGD15718 Sterility Allele fertile BsgEY10523 male sterile Bsggel Other Phenotypes Allele behavior defective | recessive BsgBG02539 body color defective, with Scer\GAL4pnr-MD237 BsgGD989 BsgGD15718 neuroanatomy defective Bsgδ265 neurophysiology defective (with Df(2L)Exel7034) BsgNP6293 stress response defective BsgBG02539 Phenotype manifest in Allele crystal cell Bsgk14308 epithelial glial cell Bsgδ265 mesothoracic tergum, with Scer\GAL4pnr-MD237 BsgGD15718 BsgGD989 mitochondrion & eye photoreceptor cell | somatic clone Bsgδ265 nerve terminal & eye photoreceptor cell | somatic clone Bsgδ265 neuron & eye photoreceptor cell | somatic clone Bsgδ265 Bsgk13638 NMJ bouton (with Df(2L)Exel7034) BsgNP6293 Bsg1217 nucleus Bsgδ265 photoreceptor cell Bsgδ265 rough endoplasmic reticulum & eye photoreceptor cell | somatic clone Bsgδ265 synaptic vesicle (with Df(2L)Exel7034) BsgNP6293 wing BsgW16 Z disc, with Scer\GAL4Mef2.PR BsgGD15718
Classical Alleles ( 46 )
For All Classical Alleles Show
Allele of Bsg Class Mutagen Stocks Known lesion BsgB39.1M2 P-element activity 2 -- Bsgk13638 hypomorphic allele - genetic evidence P-element activity 2 Yes Bsgk14308 P-element activity 2 -- BsgCB-5104-3 1 -- Bsgd02378 P-element activity 1 -- Bsgd03746 P-element activity 1 -- Bsgd06523 P-element activity 1 -- Bsgd08020 P-element activity 1 -- BsgDG30112 P-element activity 1 -- Bsgf01337 piggyBac transposase 1 -- Bsgf02023 piggyBac transposase 1 -- Bsggel P-element activity 1 -- Bsgk04604 P-element activity 1 -- Bsgk06338 P-element activity 1 -- Bsgk13510 P-element activity 1 -- BsgNP1571 1 -- BsgNP3198 1 -- BsgNP6293 1 -- Bsg06243 P-element activity 0 Yes Bsg1217 P-element activity 0 -- BsgBG02539 0 Yes Bsgc00246 0 -- Bsgc00599 piggyBac transposase 0 -- BsgCA06978 P-element activity 0 Yes BsgCPTI001762 piggyBac transposase 0 Yes BsgCPTI100005 piggyBac transposase 0 Yes BsgCPTI100050 piggyBac transposase 0 Yes BsgCPTI100062 piggyBac transposase 0 Yes Bsgd07278 0 -- BsgEP2434 P-element activity 0 -- BsgEP2588 P-element activity 0 -- BsgEP363 P-element activity 0 -- BsgEP649a P-element activity 0 -- Bsgex64 P-element activity 0 Yes BsgEY10523 P-element activity 0 -- Bsgf02104 piggyBac transposase 0 -- Bsgf04725 piggyBac transposase 0 -- BsgG00413 0 -- Bsgk07602 P-element activity 0 -- Bsgk09030 P-element activity 0 -- Bsgk09402 P-element activity 0 -- Bsgk09412 P-element activity 0 -- BsgMI03588 0 -- BsgSH1215 0 -- BsgW16 P-element activity 0 Yes Bsgδ265 P-element activity 0 Yes
Alleles Carried on Transgenic Constructs ( 27 )
For All Alleles Carried on Transgenic Constructs Show
Allele of Bsg Class Mutagen Stocks Known lesion BsgGD15718 in vitro construct - RNAi in vitro construct - regulatory fusion 2 Yes BsgGD989 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes BsgKK108920 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes Bsg265.GMR in vitro construct - regulatory fusion 0 Yes BsgD188N.Scer\UAS.T:SV5\V5 in vitro construct - regulatory fusion in vitro construct - site directed mutagenesis 0 Yes BsgDRGEY188AVRES.Scer\UAS.T:SV5\V5 in vitro construct - regulatory fusion in vitro construct - site directed mutagenesis 0 Yes BsgE235G.Scer\UAS.T:SV5\V5 in vitro construct - regulatory fusion in vitro construct - site directed mutagenesis 0 Yes BsgEG132GV.Scer\UAS.T:SV5\V5 in vitro construct - regulatory fusion in vitro construct - site directed mutagenesis 0 Yes BsgEIE113GFG.Scer\UAS.T:SV5\V5 0 Yes BsgI178T.Scer\UAS.T:SV5\V5 in vitro construct - regulatory fusion in vitro construct - site directed mutagenesis 0 Yes BsgKRR248MGG.Scer\UAS.T:SV5\V5 in vitro construct - regulatory fusion in vitro construct - site directed mutagenesis 0 Yes BsgN.Scer\UAS.T:Avic\GFP in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes BsgNGG.Scer\UAS.T:Avic\GFP in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes BsgP147L.Scer\UAS.T:SV5\V5 in vitro construct - regulatory fusion in vitro construct - site directed mutagenesis 0 Yes BsgPFL228LFT.Scer\UAS.T:SV5\V5 in vitro construct - regulatory fusion in vitro construct - site directed mutagenesis 0 Yes BsgRVK218LVT.Scer\UAS.T:SV5\V5 in vitro construct - regulatory fusion in vitro construct - site directed mutagenesis 0 Yes BsgScer\UAS.cBa in vitro construct - regulatory fusion 0 Yes BsgScer\UAS.T:SV5\V5 in vitro construct - regulatory fusion 0 Yes BsgT128A.Scer\UAS.T:SV5\V5 in vitro construct - regulatory fusion in vitro construct - site directed mutagenesis 0 Yes Bsgtrunc.Scer\UAS.T:SV5\V5 in vitro construct - regulatory fusion 0 Yes BsgW151G.Scer\UAS.T:SV5\V5 in vitro construct - regulatory fusion in vitro construct - site directed mutagenesis 0 Yes BsgWKK64LKT.Scer\UAS.T:SV5\V5 in vitro construct - regulatory fusion in vitro construct - site directed mutagenesis 0 Yes BsgY103S.Scer\UAS.T:SV5\V5 in vitro construct - regulatory fusion in vitro construct - site directed mutagenesis 0 Yes BsgYE246SG.Scer\UAS.T:SV5\V5 in vitro construct - regulatory fusion in vitro construct - site directed mutagenesis 0 Yes BsgΔextra.Scer\UAS.T:Avic\GFP in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes BsgΔextra.Scer\UAS.T:Rnor\CD2,T:Avic\GFP in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes BsgΔintra.Scer\UAS.T:Avic\GFP in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes
Aneuploid Aberrations
Not disrupted in	Df(2L)spd (BDGP Project Members, 1994-1999) Df(2L)XE-2750 (BDGP Project Members, 1994-1999, Spradling et al., 1999) Df(2L)XE-3801 (BDGP Project Members, 1994-1999)
Disrupted in	Df(2L)Exel7034 (Ryder, 2004.4.26) Df(2L)TE29Aa-11 (BDGP Project Members, 1994-1999, Spradling et al., 1999) Df(2L)Trf-C6R31 (BDGP Project Members, 1994-1999)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD989} NA P{GD15718} NA P{KK108920} NA P{UAS-Bsg.B} NA P{UAS-Bsg.D188N} NA P{UAS-Bsg.DRGEY188AVRES} NA P{UAS-Bsg.E235G} NA P{UAS-Bsg.EG132GV} NA P{UAS-Bsg.EIE113GFG} NA P{UAS-Bsg.I178T} NA P{UAS-Bsg.KRR248MGG} NA P{UAS-Bsg.NGG} NA P{UAS-Bsg.P147L} NA P{UAS-Bsg.PFL228LFT} NA P{UAS-Bsg.RVK218LVT} NA P{UAS-Bsg.T128A} NA P{UAS-Bsg.trunc} NA P{UAS-Bsg.V5} NA P{UAS-Bsg.W151G} NA P{UAS-Bsg.WKK64LKT} NA P{UAS-Bsg.Y103S} NA P{UAS-Bsg.YE246SG} NA P{UAS-Bsg.Δintra} NA P{UAS-GFP-Bsg.Δextra} NA P{UAS-GFP-Bsg} NA P{UAS-GFP-Bsg-CD2.Δextra} NA characterization construct P{GMR-Bsg.265} NA
Insertions
	Type of insertions Name Expression data insertion of enhancer trap P{lacW}Bsgk04604 No P{lacW}Bsgk06338 No P{lacW}Bsgk07602 No P{lacW}Bsgk09030 No P{lacW}Bsgk09402 No P{lacW}Bsgk09412 No P{lacW}Bsgk13510 No P{lacW}Bsgk13638 No P{lacW}Bsgk14308 No P{lacW}BsgSH1215 No P{lacW}BsgSH1217 No P{lacW}BsgW16 No P{lArB}BsgB39.1M2 No P{PZ}Bsg06243 No P{PZ}Bsggel No insertion of mobile activating element P{EP}BsgEP363 NA P{EP}BsgEP649a NA P{EP}BsgEP2434 NA P{EP}BsgEP2588 NA P{EPgy2}BsgEY10523 NA P{XP}Bsgd02378 NA P{XP}Bsgd03746 NA P{XP}Bsgd06523 NA P{XP}Bsgd07278 NA P{XP}Bsgd08020 NA miscellaneous insertions Mi{MIC}BsgMI03588 NA P{GT1}BsgBG02539 NA P{PTT-GA}BsgCA06978 NA P{PTT-GA}BsgG00413 NA P{RS3}BsgCB-5104-3 NA P{wHy}BsgDG30112 NA PBac{544.SVS-1}BsgCPTI100050 NA PBac{544.SVS-1}BsgCPTI100062 NA PBac{566.P.SVS-1}BsgCPTI100005 NA PBac{681.P.FSVS-1}BsgCPTI001762 NA PBac{PB}Bsgc00246 NA PBac{PB}Bsgc00599 NA PBac{WH}Bsgf01337 NA PBac{WH}Bsgf02023 NA PBac{WH}Bsgf02104 NA PBac{WH}Bsgf04725 NA insertion of enhancer trap binary system P{GawB}BsgNP1571 No P{GawB}BsgNP3198 No P{GawB}BsgNP6293 No
Gene Ontology: Function, Process & Cellular Component ( 10 unique terms )
Terms Based on Experimental Evidence ( 10 terms )
Molecular Function ( 0 terms)
Biological Process
CV term Evidence References
cell-cell adhesion inferred from mutant phenotype (Besse et al., 2007, Munro et al., 2010) endoplasmic reticulum localization inferred from mutant phenotype (Curtin et al., 2005) inter-male aggressive behavior inferred from mutant phenotype (Edwards et al., 2009) mitochondrion localization inferred from mutant phenotype (Curtin et al., 2005) nucleus localization inferred from mutant phenotype (Curtin et al., 2005) photoreceptor cell morphogenesis inferred from mutant phenotype (Munro et al., 2010) sarcomere organization inferred from mutant phenotype (Schnorrer et al., 2010) spermatid development inferred from mutant phenotype (Castrillon et al., 1993)
Cellular Component
CV term Evidence References
presynaptic active zone inferred from mutant phenotype (Besse et al., 2007) presynaptic cytoskeletal matrix assembled at active zones inferred from direct assay (Besse et al., 2007)
Terms Based on Predictions or Assertions ( 0 terms )
Sequence Ontology: Class of Gene
	gene   nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Protein-protein
Interacting group Assay References
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions Bsg allele Gene References BsgNP6293 mys (Reed et al., 2004) unspecified mys (Curtin et al., 2005)
External Data
Linkouts	DroID - A comprehensive database of gene and protein interactions. • FBgn0261822 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 318841
Orthologs
Genome-wide drosophilid orthologs	Dana\GF14758 Dere\GG10513 Dgri\GH11616 Dmoj\GI17919 Dper\GL24757 Dpse\GA16333 Dsec\GM16732 Dsim\GD23503 Dvir\GJ17691 Dwil\GK15320 Dyak\GE18733
Curated drosophilid orthologs	Dpse\GA16333
Linkouts	OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • NV16633 LH21099 ISCW014557 ISCW008072 ISCW005893 FBgn0236125 FBgn0217325 FBgn0204860 FBgn0194882 FBgn0171645 JGI_V11_303160 FBgn0076349 FBgn0162345 FBgn0140660 FBgn0119096 FBgn0102821 FBgn0091785 CPIJ016571 ACYPI000956 GB11183 AGAP008408 AAEL012262 PB25869 PHUM371410 GLEAN_09413
Stocks & Reagents
Stocks Listed in FlyBase ( 25 )
Bloomington	11775 P{PZ}Bsggel cn1/CyO; ry506
Harvard	- P{XP}Bsgd02378 - P{XP}Bsgd03746 - P{XP}Bsgd06523 - P{XP}Bsgd08020 - PBac{WH}Bsgf01337 - PBac{WH}Bsgf02023
Kyoto	123461 w1118; P{RS3}BsgCB-5104-3
VDRC	v105293 P{KK108920}VIE-260B v2789 w1118; P{GD989}v2789 v43306 w1118; P{GD15718}v43306 v43307 w1118; P{GD15718}v43307
	More stocks available...
Genomic Clones ( 2 )
	BACR08I01 BACR14I17 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 192 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	GH21853 IP16831 LD05560 LD19437
Other clones	DPiM_GH21853 DPiM_LD19437 MIP09559
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	GH14202 GM02321 GM02966 GM04842 GM04937 GM06025 GM06027 GM10761 GM20628 LD01834 LD05978 LD10847 LD11617 LD11960 LD12332 LD13427 LD15166 LD15214 LP02809 LP06195 RE03425 RE04606 RE04883 RE07775 RE14578 RE17375 RE22236 RE23166 RE26217 RE26815 RE26820 RE26895 RE26947 RE27027 RE27230 RE27486 RE29246 RE29291 RE30925 RE36080 RE36366 RE37586 RE39192 RE42159 RE43143 RE44121 RE44817 RE51975 RE56447 RE58278 RE58405 RE59359 RE60566 RE63550 RE63925 RE64801 RE66022 RE69421 RE69825 RE70453 RE70543 RE75169 SD08033 SD11359
Other clones	1577 7938 11578 28895 34090 34257 38376 38404 43253 44759 53315 57875 79644 82279 100470 106293 106592 117397 118260 118294 118495 144560 145200 152973 156533 159660 166692 166815 166857 175230 192001 192772 275452 282699 286265 291312 295785 CK01.11A.G7 CK01.15A.B4 CK01.25A.H8 CK01.48D.G6 CK01.58D.A4 CK01.74C.A10 CK01.85D.A8 CK01.85D.C3 CK01.87B.G6 CK01.88B.H7 CK01.89C.G3 CK01.109D.B8 CK01.112A.C10 CK01.128D.E12 CK01722 Dmel_dig_008824_0679_3132 Dmel_dig_008993_0628_1103 Dmel_neb_008722_0658_2115 Dmel_neb_011399_0376_1578 Dmel_neb_012319_0077_2559 Dmel_neb_013479_0904_3408 EC25076 EC33546 EC35774 EC36974 EC260084 EK001131 EK015238 EK022364 EK047734 EK054318 EK058633 EK067810 EK067836 EK069059 EK069532 EK083240 EK099140 EK099752 EK105912 EK112125 EK122754 EK149319 EK160229 EK162659 EK170254 EK174463 EK209444 EK215715 EK223163 EK231804 EK232081 EK232161 EK236452 EK237845 EK248218 EK248250 EK250823 EK252601 EK252861 EK256445 EK262547 EK271856 EK276420 EK279846 EK294847 EK295811 EK303053 EK305909 EK308428 EN01646 EN05134 EN09330 EP03516 EP13846 ESG014d.E21_G12 ESG015d.B21_H10 FGH103D10 FGM229F07 FGM315D09 IP16931 IP17131 LD11223 RC0-DA0001-120700-027-D12
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0261822 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 318841
Antibody Information
	polyclonal (Munro et al., 2010)
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of
Source for database merge of	Source for merge of: Bsg l(2)SH1217 (Besse et al., 2007) Source for merge of: gel BcDNA:GH21853 (FlyBase, 1996-) Source for merge of: gel CG31605 (FlyBase, 1996-) Source for merge of: gel l(2)06243 l(2)k13638 (Spradling et al., 1999) Source for merge of: gel l(2)k06338 l(2)k09030 (Beaton, 1999.12.12)
Additional comments	Source for merge of gel BcDNA:GH21853 was a shared cDNA (date:030728). (Curtin et al., 2005.2.11, FlyBase, 1996-) "smi28E" may correspond to "gel"; the P{lArB}smi28E1 insertion is 286bp upstream of the transcription start site of "gel". "smi28E" may correspond to "Bsg"; the P{lArB}smi28E1 insertion is 286bp upstream of the transcription start site of "Bsg". (Anholt et al., 2003) Source for merge of gel CG31605 was location of gel P-insert alleles inside CG31605 (date:030408). (FlyBase, 1996-)
Other Comments
	Bsg is required within the presynaptic terminal to inhibit non-synchronized evoked vesicle release, (Besse et al., 2007) Bsg is part of a transsynaptic complex regulating synaptic compartmentalization and strength, and co-ordinating plasma membrane and cortical organization. (Besse et al., 2007) Loss of Bsg function from photoreceptors results in misplacement of nuclei, rough endoplasmic reticulum and mitochondria, as well as swollen axon terminals. (Curtin et al., 2005) There is conflicting complementation data concerning the Bsg locus and mutations in CG31605. These data indicate complex complementation, which is a likely scenerio given that CG31605 is predicted by Gadfly to produce nine different transcripts and two different proteins. (Reed, 2004.2.23) 2 alleles of l(2)SH1217 recovered in a P-insertion screen. (Oh et al., 2003) New annotation (CG31605) in release 3 of the genome annotation. (FlyBase Genome Annotators, 2002-2003) Mutants isolated in a screen of the second chromosome identifying genes affecting disc morphology. (Roch et al., 1998) Postmeiotic differentiation defect. (Castrillon et al., 1993)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_164782 NM_164783 NM_164784 NM_164785 NM_164786 NM_164787 NM_164788 NM_164789 NM_164790 RefSeq (Proteins) • NP_723338 NP_723339 NP_723340 NP_723341 NP_723342 NP_723343 NP_723344 NP_723345 NP_723346 DDBJ / EMBL / GenBank • AA540081 AA820055 AAK92995 AAN10653 AAN10654 AAN10655 AAN10656 AAN10657 AAN10658 AAN10659 AAN10660 AAN10661 AAO61755 AB082425 AI402604 AQ025647 AQ025790 AQ025881 AQ026062 AQ026419 AQ026466 AW940836 AW942532 AY051571 BT005198 CL844323 CZ466591 CZ472776 CZ472777 CZ473533 CZ473534 CZ475188 CZ476037 CZ483810 CZ483811 CZ484518 CZ484519 CZ484607 CZ487277 Entrez Gene - A searchable database of RefSeq genes. • 318841 UniProtKB/TrEMBL • Q7KTJ7 Q8IPG9 Q961I4
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Immunoglobulin subtype 2 (IPR003598) Immunoglobulin subtype (IPR003599) Immunoglobulin-like (IPR007110) Immunoglobulin-like fold (IPR013783) Immunoglobulin I-set (IPR013098)
Linkouts
	DroID - A comprehensive database of gene and protein interactions. • FBgn0261822 DRSC - Results from RNAi screens. • FBgn0261822 FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0261822 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 318841 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 318841 modMine - Data generated by the modENCODE project. • FBgn0261822 OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • NV16633 LH21099 ISCW014557 ISCW008072 ISCW005893 FBgn0236125 FBgn0217325 FBgn0204860 FBgn0194882 FBgn0171645 JGI_V11_303160 FBgn0076349 FBgn0162345 FBgn0140660 FBgn0119096 FBgn0102821 FBgn0091785 CPIJ016571 ACYPI000956 GB11183 AGAP008408 AAEL012262 PB25869 PHUM371410 GLEAN_09413
Synonyms & Secondary IDs ( 19 )
Reported As
Symbol Synonym	135/10 (Roch et al., 1998) BcDNA:GH21853   bsg (Munoz-Descalzo et al., 2005, Reed et al., 2004, Curtin et al., 2005, Vecomnskie et al., 2008) Bsg (Buszczak et al., 2007, Quinones-Coello, 2007, Haerty et al., 2007, Besse et al., 2007, Rathke et al., 2007, Schnorrer et al., 2010, Munro et al., 2010, Seong et al., 2011) CG31605 (Curtin et al., 2005, Weber, 2005, Anholt, 2004, Harbison et al., 2004, Vogel et al., 2003, Giot et al., 2003, Quinones-Coello, 2007, Besse et al., 2007, Keleman et al., 2009.8.5, Cammarato et al., 2011) gel (Weber, 2005, Anholt et al., 2003, Spradling et al., 1999, Castrillon et al., 1993, Rathke et al., 2007) l(2)06243 (Meister and Braun, 1995.10, BDGP Project Members, 1994-1999, ) l(2)k06338 (BDGP Project Members, 1994-1999, ) l(2)k09030 (BDGP Project Members, 1994-1999, ) l(2)k13638 (BDGP Project Members, 1994-1999, Besse et al., 2007) l(2)k14308 (Besse et al., 2007) l(2)SH2 1217 (Oh et al., 2002.3.25) l(2)SH1217 (Besse et al., 2007, ) ms(2)08318
Name Synonym	Basigin (Reed, 2004.2.23, Reed et al., 2004, Reed et al., 2004, Curtin and Wyman, 2004, Besse et al., 2007, Edwards et al., 2009, Schnorrer et al., 2010, Cammarato et al., 2011) basigin (Vecomnskie et al., 2008, Forster et al., 2010, Munro et al., 2010) D-basigin (Curtin et al., 2005) gelded (Castrillon et al., 1993, Rathke et al., 2007) lethal (2) SH1217
Secondary FlyBase IDs
	FBgn0010613 FBgn0011219 FBgn0021878 FBgn0022015 FBgn0022136 FBgn0046227 FBgn0051605 FBgn0065497
References ( 53 )
Generate a list of	All references relating to this gene ( 53 )
List References by type	Research paper  ( 22 ) Supplementary material  ( 6 ) Review  ( 1 ) Personal communication to FlyBase  ( 12 ) Abstract  ( 3 ) FlyBase analysis  ( 4 ) Computer file  ( 4 ) DNA/RNA sequence record  ( 1 )
Recent research papers ( 5 )
	Baycin-Hizal et al., 2011, J. Proteome Res. 10(6): 2777--2784 GlycoFly: A Database of Drosophila N-linked Glycoproteins Identified Using SPEG-MS Techniques. [FBrf0213834] Seong et al., 2011, Biogerontology 12(2): 93--107 Genome-wide analysis of low-dose irradiated male Drosophila melanogaster with extended longevity. [FBrf0213307] Forster et al., 2010, Curr. Biol. 20(1): 62--68 Sec24-Dependent Secretion Drives Cell-Autonomous Expansion of Tracheal Tubes in Drosophila. [FBrf0209657] Munro et al., 2010, Gene 449(1-2): 50--58 Mutational analysis of Drosophila basigin function in the visual system. [FBrf0209222] Schnorrer et al., 2010, Nature 464(7286): 287--291 Systematic genetic analysis of muscle morphogenesis and function in Drosophila. [FBrf0210226] Show all research papers ...
Recent reviews (0)
	All reviews listed in FlyBase were published before 2010 Show reviews ...