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Gene Dmel\Bsg

General Information
Symbol	Dmel\Bsg	Species	D. melanogaster
Name	Basigin	Annotation symbol	CG31605
Feature type	protein_coding_gene	FlyBase ID	FBgn0261822
Gene Model Status	Current	Stock availability	25 publicly available
Also Known As	gel, l(2)06243, l(2)k13638
Genomic Location
Chromosome (arm)	2L	Recombination map
Cytogenetic map	28E3-28E6	Sequence location	2L:8,083,420..8,116,531 [+]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents Beta	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene Basigin is referred to in FlyBase by the symbol Dmel\Bsg (CG31605, FBgn0261822). It is a protein_coding_gene from Drosophila melanogaster. Its molecular function is unknown. There is experimental evidence that it is involved in the biological process: inter-male aggressive behavior; spermatid development; mitochondrion localization; cell-cell adhesion; sarcomere organization; photoreceptor cell morphogenesis; endoplasmic reticulum localization; nucleus localization. 74 alleles are reported. The phenotypes of these alleles are annotated with: Z disc; NMJ bouton; epithelial glial cell; photoreceptor cell; mesothoracic tergum; wing; nucleus; synaptic vesicle; crystal cell. It has 10 annotated transcripts and 10 annotated polypeptides. Protein features are: Immunoglobulin subtype; Immunoglobulin subtype 2; Immunoglobulin-like domain; Immunoglobulin-like fold. Gene sequence location is 2L:8083420..8116531.
User Contributed Data
	Beta version, feedback welcome
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 28E3-28E6   Limits computationally determined from genome sequence between P{EP}poeEP737 and P{lacW}l(2)k16919k16919&P{lacW}Bsgk09030; Left limit from in situ hybridisation (FBrf0157097) Right limit from in situ hybridisation (FBrf0157097)
Experimentally Determined Cytological Location
Cytogenetic map Notes References 28D-28D   (determined by in situ hybridisation)   (Weber et al., 2005) 28E4-28E5     (Oh et al., 2003) 28E3-28E4   (determined by in situ hybridisation)   (Spradling et al., 1999) 28D1-28D12   28D3--4 28E3--4 28E4--5   (BDGP Project Members, 1994-1999)
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\Bsg for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
	Gene model reviewed during 5.45 Tissue-specific extension of 3' UTRs observed during later stages (FBrf0218523, FBrf0219848); all variants may not be annotated Annotated transcripts do not represent all supported alternative splices within 5' UTR.
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) Bsg-RA FBtr0079567  NM_164782   2859   265 Bsg-RB FBtr0079566  NM_164783   2744   265 Bsg-RC FBtr0079569  NM_164784   3068   265 Bsg-RD FBtr0079568  NM_164785   10026   265 Bsg-RE FBtr0079570  NM_164786   2792   265 Bsg-RF FBtr0079571  NM_164787   10170   265 Bsg-RG FBtr0079574  NM_164790   8453   648 Bsg-RH FBtr0079572  NM_164788   3001   265 Bsg-RI FBtr0079573  NM_164789   2829   265 Bsg-RJ FBtr0332498  NM_001273295   8658   266
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein Bsg-PA   FBpp0079189   29.2   265   4.79     NP_723338   AAN10653 Bsg-PB   FBpp0079188   29.2   265   4.79     NP_723339   AAN10654 Bsg-PC   FBpp0079191   29.2   265   4.79     NP_723340   AAN10655 Bsg-PD   FBpp0079190   29.2   265   4.79     NP_723341   AAN10656 Bsg-PE   FBpp0079192   29.2   265   4.79     NP_723342   AAN10657 Bsg-PF   FBpp0079193   29.2   265   4.79     NP_723343   AAN10658 Bsg-PG   FBpp0079196   70.5   648   6.89     NP_723346   AAN10661 Bsg-PH   FBpp0079194   29.2   265   4.79     NP_723344   AAN10659 Bsg-PI   FBpp0079195   29.2   265   4.79     NP_723345   AAN10660 Bsg-PJ   FBpp0304774   29.3   266   4.90     NP_001260224   AGB92760
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Immunoglobulin subtype 2 (IPR003598) Immunoglobulin subtype (IPR003599) Immunoglobulin-like domain (IPR007110) Immunoglobulin-like fold (IPR013783)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA141423   AA246956   AA391684   AA391925   AA392352   AA392826   AA438534   AA439007   AA440085   AA440287   AA540081   AA695150   AA695525   AA695969   AA696031   AA698540   AA802624   AA802626   AA803388   AA820055   AE014134 AAN10653   AE014134 AAN10654   AE014134 AAN10655   AE014134 AAN10656   AE014134 AAN10657   AE014134 AAN10658   AE014134 AAN10659   AE014134 AAN10660   AE014134 AAN10661   AB082425   AE014134 AGB92760   AI238192   AI257738   AI259402   AI402604   AI546593   AQ025647   AQ025790   AQ025881   AQ026062   AQ026419   AQ026466   AW940836   AW942532   AY051571 AAK92995   BG633445   BG637981   BG640360   BI163899   BI164849   BI165076   BI167397   BI172264   BI212308   BI215657   BI216219   BI228620   BI229101   BI229106   BI229170   BI229213   BI229276   BI229450   BI229660   BI232986   BI233024   BI235115   BI239555   BI239780   BI240681   BI241983   BI352762   BI356105   BI356875   BI357594   BI358138   BI366440   BI370065   BI371400   BI371497   BI372407   BI373307   BI375687   BI376006   BI482144   BI483173   BI486049   BI486399   BI486962   BI487038   BI580920   BI607276   BP546157   BP554399   BP558512   BT005198 AAO61755   BT006333   BT029561   BT081379   CA806769   CA807033   CL844323   CO153287   CO156798   CO177794   CO179160   CO183206   CO186022   CO186716   CO189618   CO190309   CO192334   CO193429   CO193903   CO196143   CO261978   CO267276   CO269748   CO270508   CO270676   CO272110   CO273766   CO277049   CO282326   CO283243   CO288126   CO288141   CO288657   CO288856   CO295328   CO297001   CO297647   CO299092   CO300594   CO300643   CO302345   CO304531   CO305320   CO305343   CO306338   CO306849   CO306961   CO308025   CO311025   CO313166   CO313295   CO313342   CO314447   CO314813   CO314900   CO315809   CO318389   CO319157   CO319653   CO325510   CO326246   CO326583   CO326635   CO330273   CO330643   CO332293   CO333146   CO333945   CO342107   CZ466591   CZ472776   CZ472777   CZ473533   CZ473534   CZ475188   CZ476037   CZ483810   CZ483811   CZ484518   CZ484519   CZ484607   CZ487277   DN154502   EC058642   EC062469   EC065474   EC066425   EC068895   EC069393   EC073177   EC074172   EC074182   EC074192   EC077733   EC078499   EC078917   EC078967   EC079425   EC080176   EC081582   EC081609   EC081638   EC082323   EC084655   EC085008   EC085344   EC087298   EC088311   EC088767   EC089058   EC194662   EC196179   EC197741   EC198069   EC198974   EC208737   EC209204   EC211431   EC212997   EC213944   EC214648   EC215609   EC218262   EC220171   EC225185   EC225615   EC225778   EC225890   EC225894   EC227164   EC227422   EC228193   EC229849   EC230297   EC233447   EC240068   EC241118   EC242857   EC244199   EC245339   EC248761   EC250113   EC260084   EC261041   EC264532   EC264901   EL885557   EL885787   ES688749   ES688754   ES688762   ES688763   ES688766   ES688776   ES688781   ES688794   ES688798   ES688815   ES688818   ES688826   ES688827   ES688836   ES688841   ES688844   ES688850   ES688855   ES688860   ES688867   ES688890   ES688894   ES688895   ES688904   ES688906   ES688907   ES688930   ES688933   ES688937   ES688941   ES688947   ES688948   ES688957   ES688960   ES688962   ES688964   ES688970   ES688972   ES688975   ES688982   ES688983   ES688985   ES688990   ES689004   ES689009   ES689012   ES689019   ES689024   ES689027   ES689030   ES689042   ES689043   ES689048   ES689058   ES689070   ES689071   ES689074   ES689081   ES689084   ES689087   ES689101   ES689110   ES689117   ES689120   ES689131   ES689143   ES689163   ES689168   ES689171   ES689187   ES689191   ES689192   ES689197   ES689198   ES689567   ES689590   ES689612   ES689616   ES689620   ES689631   ES689638   ES689640   ES689642   ES689649   ES689651   ES689664   ES689666   ES689670   ES689673   ES689682   ES689684   ES689706   ES689711   ES689714   ES689716   ES689719   ES689728   ES689732   ES689751   ES689752   ES689762   ES689763   ES689766   ES689769   ES689771   ES689783   ES689788   ES689790   ES689793   ES689795   ES689798   ES689800   ES689818   ES689821   ES689830   ES689831   ES689833   ES689836   ES692724   ES693560   ES693577   ES693585   ES693589   ES693591   ES693592   ES693593   ES693594   ES693595   ES693603   ES693608   ES693609   ES693613   ES693616   ES693617   ES693622   ES693627   ES693641   ES693647   ES693650   ES694130   ES694138   ES694141   ES694146   ES694159   ES694181   ES694183   ES694194   ES694198   ES695472   EV579804   EV583270   EV586856   EV587077   EV588134   EV589283   EV590952   EV595485   EV597846
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL	Q8IPG9 Q7KTJ7 Q961I4
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
in situ Stage Tissue/Position (including subcellular localization) Reference embryonic stage 1 -- 3   organism | ubiquitous   (Fisher et al., 2012) Comment:maternally deposited embryonic stage 4 -- 6   organism   (Fisher et al., 2012) organism | ubiquitous   • cytoplasm | basal (Fisher et al., 2012) Comment:apically cleared embryonic stage 7 -- 8   head mesoderm   (Fisher et al., 2012) hindgut anlage   (Fisher et al., 2012) organism | ubiquitous   (Fisher et al., 2012) embryonic stage 9 -- 10   anterior endoderm   (Fisher et al., 2012) head mesoderm   (Fisher et al., 2012) posterior endoderm   (Fisher et al., 2012) inclusive hindgut primordium   (Fisher et al., 2012) organism | ubiquitous   (Fisher et al., 2012) yolk nucleus   (Fisher et al., 2012) embryonic stage 11 -- 12   anterior midgut primordium   (Fisher et al., 2012) posterior midgut primordium   (Fisher et al., 2012) amnioserosa   (Fisher et al., 2012) organism | ubiquitous   (Fisher et al., 2012) plasmatocyte primordium   (Fisher et al., 2012) Comment:reported as plasmatocytes anlage yolk nucleus   (Fisher et al., 2012) embryonic stage 13 -- 16   amnioserosa   (Fisher et al., 2012) embryonic Malpighian tubule   (Fisher et al., 2012) embryonic/larval midgut   (Fisher et al., 2012) organism | ubiquitous   (Fisher et al., 2012) yolk nucleus   (Fisher et al., 2012)
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Polypeptide Expression
mass spectroscopy Stage Tissue/Position (including subcellular localization) Reference day 7 of adulthood -- day 49 of adulthood   adult heart   (Cammarato et al., 2011)
Additional Descriptive Data
Marker for
Subcellular Localization (GO Cellular Component)
CV term Evidence References
presynaptic active zone inferred from mutant phenotype (Besse et al., 2007) presynaptic cytoskeletal matrix assembled at active zones inferred from direct assay (Besse et al., 2007)
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools
Reference	See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes.
FlyAtlas Anatomy Microarray
FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
modENCODE Anatomy RNA-Seq
modENCODE Tissue Expression Data (modENCODE_mRNA-Seq_tissues)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    19 central nervous system, larvae L3    60 central nervous system, pupae P8    133 head, virgin 1-day female    88 head, virgin 4-day female    73 head, virgin 20-day female    28 head, mated 1-day female    88 head, mated 4-day female    68 head, mated 20-day female    33 head, mated 1-day male    102 head, mated 4-day male    118 head, mated 20-day male    79 salivary gland, larvae L3 wandering    19 salivary gland, white prepupae    52 digestive system, larvae L3 wandering    100 digestive system, 1-day adult    81 digestive system, 4-day adult    113 digestive system, 20-day adult    66 fat body, larvae L3 wandering    91 fat body, white prepupae    113 fat body, pupae P8    48 carcass, larvae L3 wandering    36 carcass, 1-day adult    64 carcass, 4-day adult    60 carcass, 20-day adult    45 ovary, virgin 4-day female    36 ovary, mated 4-day female    38 testis, mated 4-day male    5 accessory gland, mated 4-day male    9 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering    19 central nervous system, larvae L3  (60) central nervous system, pupae P8  (133) head, virgin 1-day female  (88) head, virgin 4-day female  (73) head, virgin 20-day female  (28) head, mated 1-day female  (88) head, mated 4-day female  (68) head, mated 20-day female  (33) head, mated 1-day male  (102) head, mated 4-day male  (118) head, mated 20-day male  (79) salivary gland, larvae L3 wandering    19 salivary gland, white prepupae  (52) digestive system, larvae L3 wandering  (100) digestive system, 1-day adult  (81) digestive system, 4-day adult  (113) digestive system, 20-day adult  (66) fat body, larvae L3 wandering  (91) fat body, white prepupae  (113) fat body, pupae P8  (48) carcass, larvae L3 wandering  (36) carcass, 1-day adult  (64) carcass, 4-day adult  (60) carcass, 20-day adult  (45) ovary, virgin 4-day female  (36) ovary, mated 4-day female  (38) testis, mated 4-day male    5 accessory gland, mated 4-day male    9 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    19 central nervous system, larvae L3    60 central nervous system, pupae P8  (133) head, virgin 1-day female    88 head, virgin 4-day female    73 head, virgin 20-day female    28 head, mated 1-day female    88 head, mated 4-day female    68 head, mated 20-day female    33 head, mated 1-day male  102 head, mated 4-day male  (118) head, mated 20-day male    79 salivary gland, larvae L3 wandering    19 salivary gland, white prepupae    52 digestive system, larvae L3 wandering    100 digestive system, 1-day adult    81 digestive system, 4-day adult  (113) digestive system, 20-day adult    66 fat body, larvae L3 wandering    91 fat body, white prepupae  (113) fat body, pupae P8    48 carcass, larvae L3 wandering    36 carcass, 1-day adult    64 carcass, 4-day adult    60 carcass, 20-day adult    45 ovary, virgin 4-day female    36 ovary, mated 4-day female    38 testis, mated 4-day male    5 accessory gland, mated 4-day male    9 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    19 central nervous system, larvae L3    60 central nervous system, pupae P8    133 head, virgin 1-day female    88 head, virgin 4-day female    73 head, virgin 20-day female    28 head, mated 1-day female    88 head, mated 4-day female    68 head, mated 20-day female    33 head, mated 1-day male    102 head, mated 4-day male    118 head, mated 20-day male    79 salivary gland, larvae L3 wandering    19 salivary gland, white prepupae    52 digestive system, larvae L3 wandering    100 digestive system, 1-day adult    81 digestive system, 4-day adult    113 digestive system, 20-day adult    66 fat body, larvae L3 wandering    91 fat body, white prepupae    113 fat body, pupae P8    48 carcass, larvae L3 wandering    36 carcass, 1-day adult    64 carcass, 4-day adult    60 carcass, 20-day adult    45 ovary, virgin 4-day female    36 ovary, mated 4-day female    38 testis, mated 4-day male    5 accessory gland, mated 4-day male    9 Expression Level Scale  Extremely high  log, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    19 central nervous system, larvae L3    60 central nervous system, pupae P8    133 head, virgin 1-day female    88 head, virgin 4-day female    73 head, virgin 20-day female    28 head, mated 1-day female    88 head, mated 4-day female    68 head, mated 20-day female    33 head, mated 1-day male    102 head, mated 4-day male    118 head, mated 20-day male    79 salivary gland, larvae L3 wandering    19 salivary gland, white prepupae    52 digestive system, larvae L3 wandering    100 digestive system, 1-day adult    81 digestive system, 4-day adult    113 digestive system, 20-day adult    66 fat body, larvae L3 wandering    91 fat body, white prepupae    113 fat body, pupae P8    48 carcass, larvae L3 wandering    36 carcass, 1-day adult    64 carcass, 4-day adult    60 carcass, 20-day adult    45 ovary, virgin 4-day female    36 ovary, mated 4-day female    38 testis, mated 4-day male    5 accessory gland, mated 4-day male    9 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering    19 central nervous system, larvae L3  (60) central nervous system, pupae P8  (133) head, virgin 1-day female  (88) head, virgin 4-day female  (73) head, virgin 20-day female  28 head, mated 1-day female  (88) head, mated 4-day female  (68) head, mated 20-day female  (33) head, mated 1-day male  (102) head, mated 4-day male  (118) head, mated 20-day male  (79) salivary gland, larvae L3 wandering    19 salivary gland, white prepupae  (52) digestive system, larvae L3 wandering  (100) digestive system, 1-day adult  (81) digestive system, 4-day adult  (113) digestive system, 20-day adult  (66) fat body, larvae L3 wandering  (91) fat body, white prepupae  (113) fat body, pupae P8  (48) carcass, larvae L3 wandering  (36) carcass, 1-day adult  (64) carcass, 4-day adult  (60) carcass, 20-day adult  (45) ovary, virgin 4-day female  (36) ovary, mated 4-day female  (38) testis, mated 4-day male    5 accessory gland, mated 4-day male    9 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    19 central nervous system, larvae L3    60 central nervous system, pupae P8  133 head, virgin 1-day female    88 head, virgin 4-day female    73 head, virgin 20-day female    28 head, mated 1-day female    88 head, mated 4-day female    68 head, mated 20-day female    33 head, mated 1-day male  102 head, mated 4-day male  118 head, mated 20-day male    79 salivary gland, larvae L3 wandering    19 salivary gland, white prepupae    52 digestive system, larvae L3 wandering    100 digestive system, 1-day adult    81 digestive system, 4-day adult  113 digestive system, 20-day adult    66 fat body, larvae L3 wandering    91 fat body, white prepupae  113 fat body, pupae P8    48 carcass, larvae L3 wandering    36 carcass, 1-day adult    64 carcass, 4-day adult    60 carcass, 20-day adult    45 ovary, virgin 4-day female    36 ovary, mated 4-day female    38 testis, mated 4-day male    5 accessory gland, mated 4-day male    9 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    19 central nervous system, larvae L3    60 central nervous system, pupae P8    133 head, virgin 1-day female    88 head, virgin 4-day female    73 head, virgin 20-day female    28 head, mated 1-day female    88 head, mated 4-day female    68 head, mated 20-day female    33 head, mated 1-day male    102 head, mated 4-day male    118 head, mated 20-day male    79 salivary gland, larvae L3 wandering    19 salivary gland, white prepupae    52 digestive system, larvae L3 wandering    100 digestive system, 1-day adult    81 digestive system, 4-day adult    113 digestive system, 20-day adult    66 fat body, larvae L3 wandering    91 fat body, white prepupae    113 fat body, pupae P8    48 carcass, larvae L3 wandering    36 carcass, 1-day adult    64 carcass, 4-day adult    60 carcass, 20-day adult    45 ovary, virgin 4-day female    36 ovary, mated 4-day female    38 testis, mated 4-day male    5 accessory gland, mated 4-day male    9 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Tissue   Expression Level imaginal disc, larvae L3 wandering     central nervous system, larvae L3     central nervous system, pupae P8     head, virgin 1-day female     head, virgin 4-day female     head, virgin 20-day female     head, mated 1-day female     head, mated 4-day female     head, mated 20-day female     head, mated 1-day male     head, mated 4-day male     head, mated 20-day male     salivary gland, larvae L3 wandering     salivary gland, white prepupae     digestive system, larvae L3 wandering     digestive system, 1-day adult     digestive system, 4-day adult     digestive system, 20-day adult     fat body, larvae L3 wandering     fat body, white prepupae     fat body, pupae P8     carcass, larvae L3 wandering     carcass, 1-day adult     carcass, 4-day adult     carcass, 20-day adult     ovary, virgin 4-day female     ovary, mated 4-day female     testis, mated 4-day male     accessory gland, mated 4-day male
modENCODE Development RNA-Seq
modENCODE Temporal Expression Data (modENCODE_mRNA-Seq_U)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    16 embryo 02-04hr    23 embryo 04-06hr    21 embryo 06-08hr    26 embryo 08-10hr    29 embryo 10-12hr    27 embryo 12-14hr    34 embryo 14-16hr    18 embryo 16-18hr    32 embryo 18-20hr    30 embryo 20-22hr    40 embryo 22-24hr    54 larva L1    28 larva L2    30 larva L3 12hr old    23 larva L3 puffstage 1-2    18 larva L3 puffstage 3-6    34 larva L3 puffstage 7-9    56 white prepupae new    54 white prepupae 12hr    51 white prepupae 24hr    30 pupae 2d postWPP    33 pupae 3d postWPP    30 pupae 4d postWPP    25 adult male 01day    29 adult male 05day    21 adult male 30day    16 adult female 01day    21 adult female 05day    21 adult female 30day    18 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    16 embryo 02-04hr    23 embryo 04-06hr    21 embryo 06-08hr  26 embryo 08-10hr  (29) embryo 10-12hr  (27) embryo 12-14hr  (34) embryo 14-16hr    18 embryo 16-18hr  (32) embryo 18-20hr  (30) embryo 20-22hr  (40) embryo 22-24hr  (54) larva L1  (28) larva L2  (30) larva L3 12hr old    23 larva L3 puffstage 1-2    18 larva L3 puffstage 3-6  (34) larva L3 puffstage 7-9  (56) white prepupae new  (54) white prepupae 12hr  (51) white prepupae 24hr  (30) pupae 2d postWPP  (33) pupae 3d postWPP  (30) pupae 4d postWPP    25 adult male 01day  (29) adult male 05day    21 adult male 30day    16 adult female 01day    21 adult female 05day    21 adult female 30day    18 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    16 embryo 02-04hr    23 embryo 04-06hr    21 embryo 06-08hr    26 embryo 08-10hr    29 embryo 10-12hr    27 embryo 12-14hr    34 embryo 14-16hr    18 embryo 16-18hr    32 embryo 18-20hr    30 embryo 20-22hr    40 embryo 22-24hr    54 larva L1    28 larva L2    30 larva L3 12hr old    23 larva L3 puffstage 1-2    18 larva L3 puffstage 3-6    34 larva L3 puffstage 7-9    56 white prepupae new    54 white prepupae 12hr    51 white prepupae 24hr    30 pupae 2d postWPP    33 pupae 3d postWPP    30 pupae 4d postWPP    25 adult male 01day    29 adult male 05day    21 adult male 30day    16 adult female 01day    21 adult female 05day    21 adult female 30day    18 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    16 embryo 02-04hr    23 embryo 04-06hr    21 embryo 06-08hr    26 embryo 08-10hr    29 embryo 10-12hr    27 embryo 12-14hr    34 embryo 14-16hr    18 embryo 16-18hr    32 embryo 18-20hr    30 embryo 20-22hr    40 embryo 22-24hr    54 larva L1    28 larva L2    30 larva L3 12hr old    23 larva L3 puffstage 1-2    18 larva L3 puffstage 3-6    34 larva L3 puffstage 7-9    56 white prepupae new    54 white prepupae 12hr    51 white prepupae 24hr    30 pupae 2d postWPP    33 pupae 3d postWPP    30 pupae 4d postWPP    25 adult male 01day    29 adult male 05day    21 adult male 30day    16 adult female 01day    21 adult female 05day    21 adult female 30day    18 Expression Level Scale  Extremely high  log, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    16 embryo 02-04hr    23 embryo 04-06hr    21 embryo 06-08hr    26 embryo 08-10hr    29 embryo 10-12hr    27 embryo 12-14hr    34 embryo 14-16hr    18 embryo 16-18hr    32 embryo 18-20hr    30 embryo 20-22hr    40 embryo 22-24hr    54 larva L1    28 larva L2    30 larva L3 12hr old    23 larva L3 puffstage 1-2    18 larva L3 puffstage 3-6    34 larva L3 puffstage 7-9    56 white prepupae new    54 white prepupae 12hr    51 white prepupae 24hr    30 pupae 2d postWPP    33 pupae 3d postWPP    30 pupae 4d postWPP    25 adult male 01day    29 adult male 05day    21 adult male 30day    16 adult female 01day    21 adult female 05day    21 adult female 30day    18 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    16 embryo 02-04hr    23 embryo 04-06hr    21 embryo 06-08hr  26 embryo 08-10hr  29 embryo 10-12hr  27 embryo 12-14hr  (34) embryo 14-16hr    18 embryo 16-18hr  32 embryo 18-20hr  30 embryo 20-22hr  (40) embryo 22-24hr  (54) larva L1  28 larva L2  30 larva L3 12hr old    23 larva L3 puffstage 1-2    18 larva L3 puffstage 3-6  (34) larva L3 puffstage 7-9  (56) white prepupae new  (54) white prepupae 12hr  (51) white prepupae 24hr  30 pupae 2d postWPP  (33) pupae 3d postWPP  30 pupae 4d postWPP    25 adult male 01day  29 adult male 05day    21 adult male 30day    16 adult female 01day    21 adult female 05day    21 adult female 30day    18 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    16 embryo 02-04hr    23 embryo 04-06hr    21 embryo 06-08hr    26 embryo 08-10hr    29 embryo 10-12hr    27 embryo 12-14hr    34 embryo 14-16hr    18 embryo 16-18hr    32 embryo 18-20hr    30 embryo 20-22hr    40 embryo 22-24hr    54 larva L1    28 larva L2    30 larva L3 12hr old    23 larva L3 puffstage 1-2    18 larva L3 puffstage 3-6    34 larva L3 puffstage 7-9    56 white prepupae new    54 white prepupae 12hr    51 white prepupae 24hr    30 pupae 2d postWPP    33 pupae 3d postWPP    30 pupae 4d postWPP    25 adult male 01day    29 adult male 05day    21 adult male 30day    16 adult female 01day    21 adult female 05day    21 adult female 30day    18 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    16 embryo 02-04hr    23 embryo 04-06hr    21 embryo 06-08hr    26 embryo 08-10hr    29 embryo 10-12hr    27 embryo 12-14hr    34 embryo 14-16hr    18 embryo 16-18hr    32 embryo 18-20hr    30 embryo 20-22hr    40 embryo 22-24hr    54 larva L1    28 larva L2    30 larva L3 12hr old    23 larva L3 puffstage 1-2    18 larva L3 puffstage 3-6    34 larva L3 puffstage 7-9    56 white prepupae new    54 white prepupae 12hr    51 white prepupae 24hr    30 pupae 2d postWPP    33 pupae 3d postWPP    30 pupae 4d postWPP    25 adult male 01day    29 adult male 05day    21 adult male 30day    16 adult female 01day    21 adult female 05day    21 adult female 30day    18 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     modENCODE Temporal Expression Data (Graveley et al., 2011)
modENCODE Cell Lines RNA-Seq
modENCODE Cell Line Expression Data (modENCODE_mRNA-Seq_cell.A) (modENCODE_mRNA-Seq_cell.B)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    71 Schneider line 2 Sg4    15 embryonic 1182-4H    31 embryonic GM2    86 embryonic Kc167    153 embryonic S1    27 embryonic S3    83 leg disc CME L1    18 wing disc CME-W2    42 wing disc ML-DmD8    69 wing disc ML-DmD9    23 wing disc ML-DmD16-c3    81 wing disc ML-DmD21    52 wing disc ML-DmD32    131 haltere disc ML-DmD17-c3    106 eye-antennal disc ML-DmD11    41 antennal disc ML-DmD20-c5    39 mixed discs ML-DmD4-c1    104 CNS ML-DmBG1-c1    37 CNS ML-DmBG2-c2    41 tumorous blood cells mbn2    116 ovary fGS/OSS    34 ovary OSC    73 ovary OSS    36 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+  (71) Schneider line 2 Sg4    15 embryonic 1182-4H  (31) embryonic GM2  (86) embryonic Kc167  (153) embryonic S1  (27) embryonic S3  (83) leg disc CME L1    18 wing disc CME-W2  (42) wing disc ML-DmD8  (69) wing disc ML-DmD9    23 wing disc ML-DmD16-c3  (81) wing disc ML-DmD21  (52) wing disc ML-DmD32  (131) haltere disc ML-DmD17-c3  (106) eye-antennal disc ML-DmD11  (41) antennal disc ML-DmD20-c5  (39) mixed discs ML-DmD4-c1  (104) CNS ML-DmBG1-c1  (37) CNS ML-DmBG2-c2  (41) tumorous blood cells mbn2  (116) ovary fGS/OSS  (34) ovary OSC  (73) ovary OSS  (36) Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    71 Schneider line 2 Sg4    15 embryonic 1182-4H    31 embryonic GM2    86 embryonic Kc167  (153) embryonic S1    27 embryonic S3    83 leg disc CME L1    18 wing disc CME-W2    42 wing disc ML-DmD8    69 wing disc ML-DmD9    23 wing disc ML-DmD16-c3    81 wing disc ML-DmD21    52 wing disc ML-DmD32  (131) haltere disc ML-DmD17-c3  106 eye-antennal disc ML-DmD11    41 antennal disc ML-DmD20-c5    39 mixed discs ML-DmD4-c1  104 CNS ML-DmBG1-c1    37 CNS ML-DmBG2-c2    41 tumorous blood cells mbn2  (116) ovary fGS/OSS    34 ovary OSC    73 ovary OSS    36 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    71 Schneider line 2 Sg4    15 embryonic 1182-4H    31 embryonic GM2    86 embryonic Kc167    153 embryonic S1    27 embryonic S3    83 leg disc CME L1    18 wing disc CME-W2    42 wing disc ML-DmD8    69 wing disc ML-DmD9    23 wing disc ML-DmD16-c3    81 wing disc ML-DmD21    52 wing disc ML-DmD32    131 haltere disc ML-DmD17-c3    106 eye-antennal disc ML-DmD11    41 antennal disc ML-DmD20-c5    39 mixed discs ML-DmD4-c1    104 CNS ML-DmBG1-c1    37 CNS ML-DmBG2-c2    41 tumorous blood cells mbn2    116 ovary fGS/OSS    34 ovary OSC    73 ovary OSS    36 Expression Level Scale  Extremely high  log, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    71 Schneider line 2 Sg4    15 embryonic 1182-4H    31 embryonic GM2    86 embryonic Kc167    153 embryonic S1    27 embryonic S3    83 leg disc CME L1    18 wing disc CME-W2    42 wing disc ML-DmD8    69 wing disc ML-DmD9    23 wing disc ML-DmD16-c3    81 wing disc ML-DmD21    52 wing disc ML-DmD32    131 haltere disc ML-DmD17-c3    106 eye-antennal disc ML-DmD11    41 antennal disc ML-DmD20-c5    39 mixed discs ML-DmD4-c1    104 CNS ML-DmBG1-c1    37 CNS ML-DmBG2-c2    41 tumorous blood cells mbn2    116 ovary fGS/OSS    34 ovary OSC    73 ovary OSS    36 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+  (71) Schneider line 2 Sg4    15 embryonic 1182-4H  31 embryonic GM2  (86) embryonic Kc167  (153) embryonic S1  27 embryonic S3  (83) leg disc CME L1    18 wing disc CME-W2  (42) wing disc ML-DmD8  (69) wing disc ML-DmD9    23 wing disc ML-DmD16-c3  (81) wing disc ML-DmD21  (52) wing disc ML-DmD32  (131) haltere disc ML-DmD17-c3  (106) eye-antennal disc ML-DmD11  (41) antennal disc ML-DmD20-c5  (39) mixed discs ML-DmD4-c1  (104) CNS ML-DmBG1-c1  (37) CNS ML-DmBG2-c2  (41) tumorous blood cells mbn2  (116) ovary fGS/OSS  (34) ovary OSC  (73) ovary OSS  (36) Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    71 Schneider line 2 Sg4    15 embryonic 1182-4H    31 embryonic GM2    86 embryonic Kc167  (153) embryonic S1    27 embryonic S3    83 leg disc CME L1    18 wing disc CME-W2    42 wing disc ML-DmD8    69 wing disc ML-DmD9    23 wing disc ML-DmD16-c3    81 wing disc ML-DmD21    52 wing disc ML-DmD32  131 haltere disc ML-DmD17-c3  106 eye-antennal disc ML-DmD11    41 antennal disc ML-DmD20-c5    39 mixed discs ML-DmD4-c1  104 CNS ML-DmBG1-c1    37 CNS ML-DmBG2-c2    41 tumorous blood cells mbn2  116 ovary fGS/OSS    34 ovary OSC    73 ovary OSS    36 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    71 Schneider line 2 Sg4    15 embryonic 1182-4H    31 embryonic GM2    86 embryonic Kc167    153 embryonic S1    27 embryonic S3    83 leg disc CME L1    18 wing disc CME-W2    42 wing disc ML-DmD8    69 wing disc ML-DmD9    23 wing disc ML-DmD16-c3    81 wing disc ML-DmD21    52 wing disc ML-DmD32    131 haltere disc ML-DmD17-c3    106 eye-antennal disc ML-DmD11    41 antennal disc ML-DmD20-c5    39 mixed discs ML-DmD4-c1    104 CNS ML-DmBG1-c1    37 CNS ML-DmBG2-c2    41 tumorous blood cells mbn2    116 ovary fGS/OSS    34 ovary OSC    73 ovary OSS    36 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Cell Line   Expression Level Schneider line 2 S2R+     Schneider line 2 Sg4     embryonic 1182-4H     embryonic GM2     embryonic Kc167     embryonic S1     embryonic S3     leg disc CME L1     wing disc CME-W2     wing disc ML-DmD8     wing disc ML-DmD9     wing disc ML-DmD16-c3     wing disc ML-DmD21     wing disc ML-DmD32     haltere disc ML-DmD17-c3     eye-antennal disc ML-DmD11     antennal disc ML-DmD20-c5     mixed discs ML-DmD4-c1     CNS ML-DmBG1-c1     CNS ML-DmBG2-c2     tumorous blood cells mbn2     ovary fGS/OSS     ovary OSC     ovary OSS
modENCODE Treatments RNA-Seq
modENCODE Treatment Expression Data (modENCODE_mRNA-Seq_treatments)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    19 cold shock, 4-day adult    16 heat shock, 4-day adult    23 Cadmium 50 mM 6 hrs, larvae L3    15 Cadmium 50 mM 12 hrs, larvae L3    41 Cadmium 50 mM 48 hrs, 4-day adult    32 Cadmium 100 mM 48 hrs, 4-day adult    53 Copper 0.5 mM 12 hrs, larvae L3    13 Copper 15 mM 48 hrs, 4-day adult    128 Zinc 5 mM 12 hrs, larvae L3    15 Zinc 4.5 mM 48 hrs, 4-day adult    102 Ethanol 2.5% 3 hrs, larvae L3    18 Ethanol 5% 3 hrs, larvae L3    30 Ethanol 10% 3 hrs, larvae L3    17 Caffeine 1.5 mg/ml 4 hrs, larvae L3    28 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    53 Caffeine 25 mg/ml 48 hrs, 4-day adult    28 Paraquat 5 mM 48 hrs, 4-day adult    44 Paraquat 10 mM 48 hrs, 4-day adult    27 Rotenone 2 μg 12 hrs, larvae L3    26 Rotenone 8 μg 12 hrs, larvae L3    10 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult    19 cold shock, 4-day adult    16 heat shock, 4-day adult    23 Cadmium 50 mM 6 hrs, larvae L3    15 Cadmium 50 mM 12 hrs, larvae L3  (41) Cadmium 50 mM 48 hrs, 4-day adult  (32) Cadmium 100 mM 48 hrs, 4-day adult  (53) Copper 0.5 mM 12 hrs, larvae L3    13 Copper 15 mM 48 hrs, 4-day adult  (128) Zinc 5 mM 12 hrs, larvae L3    15 Zinc 4.5 mM 48 hrs, 4-day adult  (102) Ethanol 2.5% 3 hrs, larvae L3    18 Ethanol 5% 3 hrs, larvae L3  (30) Ethanol 10% 3 hrs, larvae L3    17 Caffeine 1.5 mg/ml 4 hrs, larvae L3  (28) Caffeine 2.5 mg/ml 48 hrs, 4-day adult  (53) Caffeine 25 mg/ml 48 hrs, 4-day adult  (28) Paraquat 5 mM 48 hrs, 4-day adult  (44) Paraquat 10 mM 48 hrs, 4-day adult  (27) Rotenone 2 μg 12 hrs, larvae L3  26 Rotenone 8 μg 12 hrs, larvae L3    10 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    19 cold shock, 4-day adult    16 heat shock, 4-day adult    23 Cadmium 50 mM 6 hrs, larvae L3    15 Cadmium 50 mM 12 hrs, larvae L3    41 Cadmium 50 mM 48 hrs, 4-day adult    32 Cadmium 100 mM 48 hrs, 4-day adult    53 Copper 0.5 mM 12 hrs, larvae L3    13 Copper 15 mM 48 hrs, 4-day adult  (128) Zinc 5 mM 12 hrs, larvae L3    15 Zinc 4.5 mM 48 hrs, 4-day adult  102 Ethanol 2.5% 3 hrs, larvae L3    18 Ethanol 5% 3 hrs, larvae L3    30 Ethanol 10% 3 hrs, larvae L3    17 Caffeine 1.5 mg/ml 4 hrs, larvae L3    28 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    53 Caffeine 25 mg/ml 48 hrs, 4-day adult    28 Paraquat 5 mM 48 hrs, 4-day adult    44 Paraquat 10 mM 48 hrs, 4-day adult    27 Rotenone 2 μg 12 hrs, larvae L3    26 Rotenone 8 μg 12 hrs, larvae L3    10 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    19 cold shock, 4-day adult    16 heat shock, 4-day adult    23 Cadmium 50 mM 6 hrs, larvae L3    15 Cadmium 50 mM 12 hrs, larvae L3    41 Cadmium 50 mM 48 hrs, 4-day adult    32 Cadmium 100 mM 48 hrs, 4-day adult    53 Copper 0.5 mM 12 hrs, larvae L3    13 Copper 15 mM 48 hrs, 4-day adult    128 Zinc 5 mM 12 hrs, larvae L3    15 Zinc 4.5 mM 48 hrs, 4-day adult    102 Ethanol 2.5% 3 hrs, larvae L3    18 Ethanol 5% 3 hrs, larvae L3    30 Ethanol 10% 3 hrs, larvae L3    17 Caffeine 1.5 mg/ml 4 hrs, larvae L3    28 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    53 Caffeine 25 mg/ml 48 hrs, 4-day adult    28 Paraquat 5 mM 48 hrs, 4-day adult    44 Paraquat 10 mM 48 hrs, 4-day adult    27 Rotenone 2 μg 12 hrs, larvae L3    26 Rotenone 8 μg 12 hrs, larvae L3    10 Expression Level Scale  Extremely high  log, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    19 cold shock, 4-day adult    16 heat shock, 4-day adult    23 Cadmium 50 mM 6 hrs, larvae L3    15 Cadmium 50 mM 12 hrs, larvae L3    41 Cadmium 50 mM 48 hrs, 4-day adult    32 Cadmium 100 mM 48 hrs, 4-day adult    53 Copper 0.5 mM 12 hrs, larvae L3    13 Copper 15 mM 48 hrs, 4-day adult    128 Zinc 5 mM 12 hrs, larvae L3    15 Zinc 4.5 mM 48 hrs, 4-day adult    102 Ethanol 2.5% 3 hrs, larvae L3    18 Ethanol 5% 3 hrs, larvae L3    30 Ethanol 10% 3 hrs, larvae L3    17 Caffeine 1.5 mg/ml 4 hrs, larvae L3    28 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    53 Caffeine 25 mg/ml 48 hrs, 4-day adult    28 Paraquat 5 mM 48 hrs, 4-day adult    44 Paraquat 10 mM 48 hrs, 4-day adult    27 Rotenone 2 μg 12 hrs, larvae L3    26 Rotenone 8 μg 12 hrs, larvae L3    10 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult    19 cold shock, 4-day adult    16 heat shock, 4-day adult    23 Cadmium 50 mM 6 hrs, larvae L3    15 Cadmium 50 mM 12 hrs, larvae L3  (41) Cadmium 50 mM 48 hrs, 4-day adult  32 Cadmium 100 mM 48 hrs, 4-day adult  (53) Copper 0.5 mM 12 hrs, larvae L3    13 Copper 15 mM 48 hrs, 4-day adult  (128) Zinc 5 mM 12 hrs, larvae L3    15 Zinc 4.5 mM 48 hrs, 4-day adult  (102) Ethanol 2.5% 3 hrs, larvae L3    18 Ethanol 5% 3 hrs, larvae L3  30 Ethanol 10% 3 hrs, larvae L3    17 Caffeine 1.5 mg/ml 4 hrs, larvae L3  28 Caffeine 2.5 mg/ml 48 hrs, 4-day adult  (53) Caffeine 25 mg/ml 48 hrs, 4-day adult  28 Paraquat 5 mM 48 hrs, 4-day adult  (44) Paraquat 10 mM 48 hrs, 4-day adult  27 Rotenone 2 μg 12 hrs, larvae L3  26 Rotenone 8 μg 12 hrs, larvae L3    10 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    19 cold shock, 4-day adult    16 heat shock, 4-day adult    23 Cadmium 50 mM 6 hrs, larvae L3    15 Cadmium 50 mM 12 hrs, larvae L3    41 Cadmium 50 mM 48 hrs, 4-day adult    32 Cadmium 100 mM 48 hrs, 4-day adult    53 Copper 0.5 mM 12 hrs, larvae L3    13 Copper 15 mM 48 hrs, 4-day adult  128 Zinc 5 mM 12 hrs, larvae L3    15 Zinc 4.5 mM 48 hrs, 4-day adult  102 Ethanol 2.5% 3 hrs, larvae L3    18 Ethanol 5% 3 hrs, larvae L3    30 Ethanol 10% 3 hrs, larvae L3    17 Caffeine 1.5 mg/ml 4 hrs, larvae L3    28 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    53 Caffeine 25 mg/ml 48 hrs, 4-day adult    28 Paraquat 5 mM 48 hrs, 4-day adult    44 Paraquat 10 mM 48 hrs, 4-day adult    27 Rotenone 2 μg 12 hrs, larvae L3    26 Rotenone 8 μg 12 hrs, larvae L3    10 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    19 cold shock, 4-day adult    16 heat shock, 4-day adult    23 Cadmium 50 mM 6 hrs, larvae L3    15 Cadmium 50 mM 12 hrs, larvae L3    41 Cadmium 50 mM 48 hrs, 4-day adult    32 Cadmium 100 mM 48 hrs, 4-day adult    53 Copper 0.5 mM 12 hrs, larvae L3    13 Copper 15 mM 48 hrs, 4-day adult    128 Zinc 5 mM 12 hrs, larvae L3    15 Zinc 4.5 mM 48 hrs, 4-day adult    102 Ethanol 2.5% 3 hrs, larvae L3    18 Ethanol 5% 3 hrs, larvae L3    30 Ethanol 10% 3 hrs, larvae L3    17 Caffeine 1.5 mg/ml 4 hrs, larvae L3    28 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    53 Caffeine 25 mg/ml 48 hrs, 4-day adult    28 Paraquat 5 mM 48 hrs, 4-day adult    44 Paraquat 10 mM 48 hrs, 4-day adult    27 Rotenone 2 μg 12 hrs, larvae L3    26 Rotenone 8 μg 12 hrs, larvae L3    10 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Treatment   Expression Level extended cold, 4-day adult     cold shock, 4-day adult     heat shock, 4-day adult     Cadmium 50 mM 6 hrs, larvae L3     Cadmium 50 mM 12 hrs, larvae L3     Cadmium 50 mM 48 hrs, 4-day adult     Cadmium 100 mM 48 hrs, 4-day adult     Copper 0.5 mM 12 hrs, larvae L3     Copper 15 mM 48 hrs, 4-day adult     Zinc 5 mM 12 hrs, larvae L3     Zinc 4.5 mM 48 hrs, 4-day adult     Ethanol 2.5% 3 hrs, larvae L3     Ethanol 5% 3 hrs, larvae L3     Ethanol 10% 3 hrs, larvae L3     Caffeine 1.5 mg/ml 4 hrs, larvae L3     Caffeine 2.5 mg/ml 48 hrs, 4-day adult     Caffeine 25 mg/ml 48 hrs, 4-day adult     Paraquat 5 mM 48 hrs, 4-day adult     Paraquat 10 mM 48 hrs, 4-day adult     Rotenone 2 μg 12 hrs, larvae L3     Rotenone 8 μg 12 hrs, larvae L3
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010, Graveley et al., 2011) mE2_34_mRNA_expression_cluster_25 mE1_20_mRNA_expression_cluster_10
External Data & Images
Linkouts	BDGP expression data • LD05560 LD19437
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele lethal | embryonic stage | recessive Bsgex64 Bsgδ265 lethal | larval stage | recessive Bsg06243 Bsgk13638 lethal | partially | recessive BsgNP6293 lethal | recessive Bsg1217 Bsg06243 Bsgk04604 Bsgk06338 Bsgk07602 Bsgk09030 Bsgk09402 Bsgk09412 Bsgk13510 Bsgk13638 Bsgk14308 partially lethal - majority die | larval stage (with Df(2L)Exel7034) Bsg1217 Bsgk13638 Bsgk14308 BsgNP3198 BsgNP6293 partially lethal - majority die | late embryonic stage (with Df(2L)Exel7034) Bsg1217 Bsgk13638 Bsgk14308 BsgNP3198 BsgNP6293 viable BsgCA06978 BsgEY10523 BsgW16 viable, with Scer\GAL4pnr-MD237 BsgGD989 BsgGD15718 Sterility Allele fertile BsgEY10523 male sterile Bsggel Other Phenotypes Allele behavior defective | recessive BsgBG02539 body color defective, with Scer\GAL4pnr-MD237 BsgGD989 BsgGD15718 neuroanatomy defective Bsgδ265 neurophysiology defective (with Df(2L)Exel7034) BsgNP6293 stress response defective BsgBG02539 Phenotype manifest in Allele crystal cell Bsgk14308 epithelial glial cell Bsgδ265 mesothoracic tergum, with Scer\GAL4pnr-MD237 BsgGD15718 BsgGD989 mitochondrion & eye photoreceptor cell | somatic clone Bsgδ265 nerve terminal & eye photoreceptor cell | somatic clone Bsgδ265 neuron & eye photoreceptor cell | somatic clone Bsgδ265 Bsgk13638 NMJ bouton (with Df(2L)Exel7034) BsgNP6293 Bsg1217 nucleus Bsgδ265 photoreceptor cell Bsgδ265 rough endoplasmic reticulum & eye photoreceptor cell | somatic clone Bsgδ265 synaptic vesicle (with Df(2L)Exel7034) BsgNP6293 wing BsgW16 Z disc, with Scer\GAL4Mef2.PR BsgGD15718
Classical Alleles ( 46 )
For All Classical Alleles Show
Allele of Bsg Class Mutagen Stocks Known lesion BsgB39.1M2 P-element activity 2 -- Bsgk13638 hypomorphic allele - genetic evidence P-element activity 2 Yes Bsgk14308 P-element activity 2 -- BsgCB-5104-3 1 -- Bsgd02378 P-element activity 1 -- Bsgd03746 P-element activity 1 -- Bsgd06523 P-element activity 1 -- Bsgd08020 P-element activity 1 -- Bsgf01337 piggyBac transposase 1 -- Bsgf02023 piggyBac transposase 1 -- Bsggel P-element activity 1 -- Bsgk04604 P-element activity 1 -- Bsgk06338 P-element activity 1 -- Bsgk13510 P-element activity 1 -- BsgMI03588 1 -- BsgNP1571 1 -- BsgNP3198 1 -- BsgNP6293 1 -- Bsg06243 P-element activity 0 Yes Bsg1217 P-element activity 0 -- BsgBG02539 0 Yes Bsgc00246 0 -- Bsgc00599 piggyBac transposase 0 -- BsgCA06978 P-element activity 0 Yes BsgCPTI001762 piggyBac transposase 0 Yes BsgCPTI100005 piggyBac transposase 0 Yes BsgCPTI100050 piggyBac transposase 0 Yes BsgCPTI100062 piggyBac transposase 0 Yes Bsgd07278 0 -- BsgDG30112 P-element activity 0 -- BsgEP2434 P-element activity 0 -- BsgEP2588 P-element activity 0 -- BsgEP363 P-element activity 0 -- BsgEP649a P-element activity 0 -- Bsgex64 P-element activity 0 Yes BsgEY10523 P-element activity 0 -- Bsgf02104 piggyBac transposase 0 -- Bsgf04725 piggyBac transposase 0 -- BsgG00413 0 -- Bsgk07602 P-element activity 0 -- Bsgk09030 P-element activity 0 -- Bsgk09402 P-element activity 0 -- Bsgk09412 P-element activity 0 -- BsgSH1215 0 -- BsgW16 P-element activity 0 Yes Bsgδ265 P-element activity 0 Yes
Alleles Carried on Transgenic Constructs ( 28 )
For All Alleles Carried on Transgenic Constructs Show
Allele of Bsg Class Mutagen Stocks Known lesion BsgGD15718 in vitro construct - RNAi in vitro construct - regulatory fusion 2 Yes BsgGD989 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes BsgKK108920 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes Bsg265.GMR in vitro construct - regulatory fusion 0 Yes BsgD188N.Scer\UAS.T:SV5\V5 in vitro construct - regulatory fusion in vitro construct - site directed mutagenesis 0 Yes BsgDRGEY188AVRES.Scer\UAS.T:SV5\V5 in vitro construct - regulatory fusion in vitro construct - site directed mutagenesis 0 Yes BsgE235G.Scer\UAS.T:SV5\V5 in vitro construct - regulatory fusion in vitro construct - site directed mutagenesis 0 Yes BsgEG132GV.Scer\UAS.T:SV5\V5 in vitro construct - regulatory fusion in vitro construct - site directed mutagenesis 0 Yes BsgEIE113GFG.Scer\UAS.T:SV5\V5 0 Yes BsgI178T.Scer\UAS.T:SV5\V5 in vitro construct - regulatory fusion in vitro construct - site directed mutagenesis 0 Yes BsgKRR248MGG.Scer\UAS.T:SV5\V5 in vitro construct - regulatory fusion in vitro construct - site directed mutagenesis 0 Yes BsgN.Scer\UAS.T:Avic\GFP in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes BsgNGG.Scer\UAS.T:Avic\GFP in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes BsgNIG.31605R in vitro construct - RNAi in vitro construct - regulatory fusion 0 Yes BsgP147L.Scer\UAS.T:SV5\V5 in vitro construct - regulatory fusion in vitro construct - site directed mutagenesis 0 Yes BsgPFL228LFT.Scer\UAS.T:SV5\V5 in vitro construct - regulatory fusion in vitro construct - site directed mutagenesis 0 Yes BsgRVK218LVT.Scer\UAS.T:SV5\V5 in vitro construct - regulatory fusion in vitro construct - site directed mutagenesis 0 Yes BsgScer\UAS.cBa in vitro construct - regulatory fusion 0 Yes BsgScer\UAS.T:SV5\V5 in vitro construct - regulatory fusion 0 Yes BsgT128A.Scer\UAS.T:SV5\V5 in vitro construct - regulatory fusion in vitro construct - site directed mutagenesis 0 Yes Bsgtrunc.Scer\UAS.T:SV5\V5 in vitro construct - regulatory fusion 0 Yes BsgW151G.Scer\UAS.T:SV5\V5 in vitro construct - regulatory fusion in vitro construct - site directed mutagenesis 0 Yes BsgWKK64LKT.Scer\UAS.T:SV5\V5 in vitro construct - regulatory fusion in vitro construct - site directed mutagenesis 0 Yes BsgY103S.Scer\UAS.T:SV5\V5 in vitro construct - regulatory fusion in vitro construct - site directed mutagenesis 0 Yes BsgYE246SG.Scer\UAS.T:SV5\V5 in vitro construct - regulatory fusion in vitro construct - site directed mutagenesis 0 Yes BsgΔextra.Scer\UAS.T:Avic\GFP in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes BsgΔextra.Scer\UAS.T:Rnor\CD2,T:Avic\GFP in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes BsgΔintra.Scer\UAS.T:Avic\GFP in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes
Aneuploid Aberrations
Not disrupted in	Df(2L)spd (BDGP Project Members, 1994-1999) Df(2L)XE-2750 (BDGP Project Members, 1994-1999, Spradling et al., 1999) Df(2L)XE-3801 (BDGP Project Members, 1994-1999)
Disrupted in	Df(2L)Exel7034 (Ryder, 2004.4.26) Df(2L)TE29Aa-11 (BDGP Project Members, 1994-1999, Spradling et al., 1999) Df(2L)Trf-C6R31 (BDGP Project Members, 1994-1999)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD989} NA P{GD15718} NA P{KK108920} NA P{NIG.31605R} NA P{UAS-Bsg.B} NA P{UAS-Bsg.D188N} NA P{UAS-Bsg.DRGEY188AVRES} NA P{UAS-Bsg.E235G} NA P{UAS-Bsg.EG132GV} NA P{UAS-Bsg.EIE113GFG} NA P{UAS-Bsg.I178T} NA P{UAS-Bsg.KRR248MGG} NA P{UAS-Bsg.NGG} NA P{UAS-Bsg.P147L} NA P{UAS-Bsg.PFL228LFT} NA P{UAS-Bsg.RVK218LVT} NA P{UAS-Bsg.T128A} NA P{UAS-Bsg.trunc} NA P{UAS-Bsg.V5} NA P{UAS-Bsg.W151G} NA P{UAS-Bsg.WKK64LKT} NA P{UAS-Bsg.Y103S} NA P{UAS-Bsg.YE246SG} NA P{UAS-Bsg.Δintra} NA P{UAS-GFP-Bsg.Δextra} NA P{UAS-GFP-Bsg} NA P{UAS-GFP-Bsg-CD2.Δextra} NA characterization construct P{GMR-Bsg.265} NA
Insertions
	Type of insertions Name Expression data insertion of enhancer trap P{lacW}Bsgk04604 No P{lacW}Bsgk06338 No P{lacW}Bsgk07602 No P{lacW}Bsgk09030 No P{lacW}Bsgk09402 No P{lacW}Bsgk09412 No P{lacW}Bsgk13510 No P{lacW}Bsgk13638 No P{lacW}Bsgk14308 No P{lacW}BsgSH1215 No P{lacW}BsgSH1217 No P{lacW}BsgW16 No P{lArB}BsgB39.1M2 No P{PZ}Bsg06243 No P{PZ}Bsggel No insertion of mobile activating element P{EP}BsgEP363 NA P{EP}BsgEP649a NA P{EP}BsgEP2434 NA P{EP}BsgEP2588 NA P{EPgy2}BsgEY10523 NA P{XP}Bsgd02378 NA P{XP}Bsgd03746 NA P{XP}Bsgd06523 NA P{XP}Bsgd07278 NA P{XP}Bsgd08020 NA miscellaneous insertions Mi{MIC}BsgMI03588 NA P{GT1}BsgBG02539 NA P{PTT-GA}BsgCA06978 NA P{PTT-GA}BsgG00413 NA P{RS3}BsgCB-5104-3 NA P{wHy}BsgDG30112 NA PBac{544.SVS-1}BsgCPTI100050 NA PBac{544.SVS-1}BsgCPTI100062 NA PBac{566.P.SVS-1}BsgCPTI100005 NA PBac{681.P.FSVS-1}BsgCPTI001762 NA PBac{PB}Bsgc00246 NA PBac{PB}Bsgc00599 NA PBac{WH}Bsgf01337 NA PBac{WH}Bsgf02023 NA PBac{WH}Bsgf02104 NA PBac{WH}Bsgf04725 NA insertion of enhancer trap binary system P{GawB}BsgNP1571 No P{GawB}BsgNP3198 No P{GawB}BsgNP6293 No
Gene Ontology: Function, Process & Cellular Component ( 10 unique terms )
Terms Based on Experimental Evidence ( 10 terms )
Molecular Function ( 0 terms)
Biological Process
CV term Evidence References
cell-cell adhesion inferred from mutant phenotype (Besse et al., 2007, Munro et al., 2010) endoplasmic reticulum localization inferred from mutant phenotype (Curtin et al., 2005) inter-male aggressive behavior inferred from mutant phenotype (Edwards et al., 2009) mitochondrion localization inferred from mutant phenotype (Curtin et al., 2005) nucleus localization inferred from mutant phenotype (Curtin et al., 2005) photoreceptor cell morphogenesis inferred from mutant phenotype (Munro et al., 2010) sarcomere organization inferred from mutant phenotype (Schnorrer et al., 2010) spermatid development inferred from mutant phenotype (Castrillon et al., 1993)
Cellular Component
CV term Evidence References
presynaptic active zone inferred from mutant phenotype (Besse et al., 2007) presynaptic cytoskeletal matrix assembled at active zones inferred from direct assay (Besse et al., 2007)
Terms Based on Predictions or Assertions ( 0 terms )
Sequence Ontology: Class of Gene
	gene   nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
protein-protein
Interacting group Assay References
Bsg - Arf79F anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Bsg - CG15098 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Bsg - CG3817 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Bsg - CG6937 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Bsg - Gp210 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Bsg - Pde8 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Bsg - RhoGEF3 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Bsg - RpS15Ab experimental knowledge based, anti tag coimmunoprecipitation, peptide massfingerprinting (Guruharsha et al., 2011, Mintseris et al., 2009.11.23) Bsg - Trap1 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Bsg - Vha68-2 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Bsg - sw anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Bsg - tmod anti tag coimmunoprecipitation, peptide massfingerprinting, experimental knowledge based (Mintseris et al., 2009.11.23, Guruharsha et al., 2011)
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions Bsg allele Gene References BsgNP6293 mys (Reed et al., 2004) unspecified mys (Curtin et al., 2005)
External Data
Linkouts	DroID - A comprehensive database of gene and protein interactions. • FBgn0261822 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 318841
Orthologs
OrthoDB Orthologs (33) - based on analysis using Dmel annotation version 5.41
OrthoDB Ortholog Groups
	OrthoDB orthology group searches (Waterhouse et al., 2011, Nucleic Acids Res. 39(Database issue): D283--D288) Drosophila inclusive ortholog search EOG666W68 Dipteran inclusive ortholog search EOG64F6K5 Insect inclusive ortholog search EOG647DPT Arthropod inclusive ortholog search EOG64F4RQ Metazoa inclusive ortholog search EOG6BKHXJ
Orthologs in Drosophila Species (EOG666W68)
Organism Common Name Gene AAA Syntenic Ortholog Multiple Dmel Genes in this Orthologous Group Drosophila melanogaster fruit fly  Dmel\Bsg     Drosophila simulans   Dsim\GD23503 Y   Drosophila sechellia   Dsec\GM16732 Y   Drosophila erecta   Dere\GG10513 Y   Drosophila yakuba   Dyak\GE18733 Y   Drosophila ananassae   Dana\GF14758 Y   Drosophila pseudoobscura pseudoobscura   Dpse\GA16333 Y   Drosophila persimilis   Dper\GL24757 Y   Drosophila willistoni   Dwil\GK15320 Y   Drosophila virilis   Dvir\GJ17691 Y   Drosophila virilis   Dvir\GJ20377     Drosophila mojavensis   Dmoj\GI17919 Y   Drosophila grimshawi   Dgri\GH11616 Y
Orthologs in non-Drosophila Dipterans (EOG64F6K5)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Aedes aegypti Yellow fever mosquito  Aaeg\AAEL012262   Anopheles gambiae Malaria mosquito  Agam\AGAP008408   Culex quinquefasciatus Southern house mosquito  Cqui\CPIJ802371
Orthologs in non-Dipteran Insects (EOG647DPT)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Apis mellifera Western honey bee  Amel\GB44726   Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG014305   Acromyrmex echinatior Panamanian leafcutter ant  Aech\AECH12337   Atta cephalotes Leafcutter ant  Acep\ACEP24897   Camponotus floridanus Florida carpenter ant  Cflo\CFLO17572   Harpegnathos saltator Jerdons jumping ant  Hsal\HSAL13037   Linepithema humile Argentine ant  Lhum\LH21099   Pogonomyrmex barbatus Red harvester ant  Pbar\PB25869   Solenopsis invicta Red fire ant  Sinv\SINV10185   Acyrthosiphon pisum Pea aphid  Apim\ACYPI000956   Pediculus humanus Human body louse  Phum\PHUM371410   Tribolium castaneum Red flour beetle  Tcas\TC009413
Orthologs in non-Insect Arthropods (EOG64F4RQ)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Daphnia pulex Water flea  Dpux\CP   Ixodes scapularis Deer tick  Isca\ISCW005893   Ixodes scapularis Deer tick  Isca\ISCW008072   Ixodes scapularis Deer tick  Isca\ISCW014557
Orthologs in non-Arthropod Metazoa (EOG6BKHXJ)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_026287gn
Human Orthologs (0)
Gene OMIM HGNC
AAA Orthologs (11) based on analysis using Dmel annotation version 4.3
Organism Gene Drosophila simulans Dsim\GD23503 Drosophila sechellia Dsec\GM16732 Drosophila erecta Dere\GG10513 Drosophila yakuba Dyak\GE18733 Drosophila ananassae Dana\GF14758 Drosophila pseudoobscura pseudoobscura Dpse\GA16333 Drosophila persimilis Dper\GL24757 Drosophila willistoni Dwil\GK15320 Drosophila virilis Dvir\GJ17691 Drosophila mojavensis Dmoj\GI17919 Drosophila grimshawi Dgri\GH11616
Stocks & Reagents
Stocks Listed in FlyBase ( 25 )
Bloomington	37061 y1 w*; Mi{MIC}BsgMI03588
Harvard	- P{XP}Bsgd02378 - P{XP}Bsgd03746 - P{XP}Bsgd06523 - P{XP}Bsgd08020 - PBac{WH}Bsgf01337 - PBac{WH}Bsgf02023
Kyoto	123461 w1118; P{RS3}BsgCB-5104-3
VDRC	v105293 P{KK108920}VIE-260B v2789 w1118; P{GD989}v2789 v43306 w1118; P{GD15718}v43306 v43307 w1118; P{GD15718}v43307
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Genomic Clones ( 2 )
	BACR08I01 BACR14I17 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 216 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	GH21853 IP16831 LD05560 LD19437
Other clones	DPiM_GH21853 DPiM_LD19437 MIP09559
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	GH14202 GH27162 GM02321 GM02966 GM04842 GM04937 GM06025 GM06027 GM10761 GM20628 HL04885 LD01834 LD05978 LD10847 LD11617 LD11960 LD12332 LD13427 LD15166 LD15214 LP02809 LP06195 RE03425 RE04606 RE04883 RE07775 RE14578 RE17375 RE22236 RE23166 RE26217 RE26815 RE26820 RE26895 RE26947 RE27027 RE27230 RE27486 RE29246 RE29291 RE30925 RE36080 RE36366 RE37586 RE39192 RE42159 RE43143 RE44121 RE44817 RE51975 RE56447 RE58278 RE58405 RE59359 RE60566 RE63550 RE63925 RE64801 RE66022 RE69421 RE69825 RE70453 RE70543 RE75169 RH74304 SD08033 SD11359
Other clones	1577 7938 11578 28895 34090 34257 38376 38404 43253 44759 53315 54120 55877 57617 57690 57875 79644 82279 100470 106293 106592 108593 117397 118260 118294 118495 118590 144560 145200 152973 156533 159660 166692 166815 166857 175230 192001 192772 275452 282699 286265 291312 295785 CK01.11A.G7 CK01.15A.B4 CK01.25A.H8 CK01.48D.G6 CK01.55D.H9 CK01.58D.A4 CK01.74C.A10 CK01.85D.A8 CK01.85D.C3 CK01.87B.G6 CK01.88B.H7 CK01.89C.G3 CK01.109D.B8 CK01.112A.C10 CK01.128D.E12 CK01.129B.H4 CK01722 Dmel_dig_008824_0679_3132 Dmel_dig_008993_0628_1103 Dmel_neb_008722_0658_2115 Dmel_neb_011399_0376_1578 Dmel_neb_012066_0094_1376 Dmel_neb_012319_0077_2559 Dmel_neb_013232_0171_2247 Dmel_neb_013479_0904_3408 Dmel_neb_015102_0333_0852 EC25076 EC33546 EC35774 EC36974 EC260084 EK001131 EK015238 EK022364 EK044729 EK047734 EK054318 EK058633 EK067810 EK067836 EK069059 EK069532 EK083240 EK095762 EK099140 EK099752 EK105912 EK112125 EK122754 EK149319 EK160229 EK162659 EK170254 EK174463 EK178650 EK178849 EK183948 EK196662 EK209444 EK215715 EK223163 EK231804 EK232081 EK232161 EK236452 EK237845 EK238258 EK245025 EK248218 EK248250 EK250823 EK252601 EK252861 EK256445 EK262547 EK271856 EK276420 EK279846 EK294847 EK295811 EK303053 EK305909 EK308428 EN01646 EN05134 EN09330 EP03516 EP04245 EP04345 EP13846 ESG014d.E21_G12 ESG015d.B21_H10 FGH103D10 FGM229F07 FGM315D09 IP16931 IP17131 LD11223 RC0-DA0001-120700-027-D12
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0261822 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 318841
Antibody Information
	polyclonal (Munro et al., 2010)
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of
Source for database merge of	Source for merge of: Bsg l(2)SH1217 (Besse et al., 2007) Source for merge of: gel BcDNA:GH21853 (FlyBase, 1996-) Source for merge of: gel CG31605 (FlyBase, 1996-) Source for merge of: gel l(2)06243 l(2)k13638 (Spradling et al., 1999) Source for merge of: gel l(2)k06338 l(2)k09030 (Beaton, 1999.12.12)
Additional comments	Source for merge of gel BcDNA:GH21853 was a shared cDNA (date:030728). (Curtin et al., 2005.2.11, FlyBase, 1996-) "smi28E" may correspond to "gel"; the P{lArB}smi28E1 insertion is 286bp upstream of the transcription start site of "gel". "smi28E" may correspond to "Bsg"; the P{lArB}smi28E1 insertion is 286bp upstream of the transcription start site of "Bsg". (Anholt et al., 2003) Source for merge of gel CG31605 was location of gel P-insert alleles inside CG31605 (date:030408). (FlyBase, 1996-)
Other Comments
	Bsg is required within the presynaptic terminal to inhibit non-synchronized evoked vesicle release, (Besse et al., 2007) Bsg is part of a transsynaptic complex regulating synaptic compartmentalization and strength, and co-ordinating plasma membrane and cortical organization. (Besse et al., 2007) Loss of Bsg function from photoreceptors results in misplacement of nuclei, rough endoplasmic reticulum and mitochondria, as well as swollen axon terminals. (Curtin et al., 2005) There is conflicting complementation data concerning the Bsg locus and mutations in CG31605. These data indicate complex complementation, which is a likely scenerio given that CG31605 is predicted by Gadfly to produce nine different transcripts and two different proteins. (Reed, 2004.2.23) 2 alleles of l(2)SH1217 recovered in a P-insertion screen. (Oh et al., 2003) New annotation (CG31605) in release 3 of the genome annotation. (FlyBase Genome Annotators, 2002-2003) Mutants isolated in a screen of the second chromosome identifying genes affecting disc morphology. (Roch et al., 1998) Postmeiotic differentiation defect. (Castrillon et al., 1993)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_164782 NM_164783 NM_164784 NM_164785 NM_164786 NM_164787 NM_164788 NM_164789 NM_164790 NM_001273295 RefSeq (Proteins) • NP_723338 NP_723339 NP_723340 NP_723341 NP_723342 NP_723343 NP_723344 NP_723345 NP_723346 NP_001260224 DDBJ / EMBL / GenBank • AA540081 AA820055 AAK92995 AAN10653 AAN10654 AAN10655 AAN10656 AAN10657 AAN10658 AAN10659 AAN10660 AAN10661 AAO61755 AB082425 AGB92760 AI402604 AQ025647 AQ025790 AQ025881 AQ026062 AQ026419 AQ026466 AW940836 AW942532 AY051571 BT005198 CL844323 CZ466591 CZ472776 CZ472777 CZ473533 CZ473534 CZ475188 CZ476037 CZ483810 CZ483811 CZ484518 CZ484519 CZ484607 CZ487277 Entrez Gene - A searchable database of RefSeq genes. • 318841 UniProtKB/TrEMBL • Q7KTJ7 Q8IPG9 Q961I4
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Immunoglobulin subtype 2 (IPR003598) Immunoglobulin subtype (IPR003599) Immunoglobulin-like domain (IPR007110) Immunoglobulin-like fold (IPR013783) BDGP expression data - Patterns of gene expression in Drosophila embryogenesis • LD05560 LD19437
Linkouts
	DroID - A comprehensive database of gene and protein interactions. • FBgn0261822 DRSC - Results from RNAi screens. • FBgn0261822 FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0261822 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 318841 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 318841 modMine - Data generated by the modENCODE project. • FBgn0261822
Synonyms & Secondary IDs ( 20 )
Reported As
Symbol Synonym	135/10 (Roch et al., 1998) BcDNA:GH21853   Bsg (Knowles-Barley et al., 2010, Buszczak et al., 2007, Quinones-Coello, 2007, Haerty et al., 2007, Besse et al., 2007, Rathke et al., 2007, Schnorrer et al., 2010, Munro et al., 2010, Seong et al., 2011, Japanese National Institute of Genetics, 2012.5.21) bsg (Belacortu et al., 2011, Munoz-Descalzo et al., 2005, Reed et al., 2004, Curtin et al., 2005, Vecomnskie et al., 2008) CG31605 (Castillo et al., 2011, Curtin et al., 2005, Weber et al., 2005, Anholt, 2004, Harbison et al., 2004, Vogel et al., 2003, Giot et al., 2003, Quinones-Coello, 2007, Besse et al., 2007, Keleman et al., 2009.8.5, Cammarato et al., 2011) gel (Weber et al., 2005, Anholt et al., 2003, Spradling et al., 1999, Castrillon et al., 1993, Rathke et al., 2007) l(2)06243 (Meister and Braun, 1995.10, BDGP Project Members, 1994-1999, ) l(2)k06338 (BDGP Project Members, 1994-1999, ) l(2)k09030 (BDGP Project Members, 1994-1999, ) l(2)k13638 (BDGP Project Members, 1994-1999, Besse et al., 2007) l(2)k14308 (Besse et al., 2007) l(2)SH2 1217 (Oh et al., 2002.3.25) l(2)SH1217 (Besse et al., 2007, ) ms(2)08318   NP6293 (Strand and Micchelli, 2011)
Name Synonym	Basigin (Reed, 2004.2.23, Reed et al., 2004, Reed et al., 2004, Curtin and Wyman, 2004, Besse et al., 2007, Edwards et al., 2009, Schnorrer et al., 2010, Cammarato et al., 2011) basigin (Vecomnskie et al., 2008, Forster et al., 2010, Munro et al., 2010, Belacortu et al., 2011) D-basigin (Curtin et al., 2005) gelded (Castrillon et al., 1993, Rathke et al., 2007) lethal (2) SH1217
Secondary FlyBase IDs
	FBgn0010613 FBgn0011219 FBgn0021878 FBgn0022015 FBgn0022136 FBgn0046227 FBgn0051605 FBgn0065497
References ( 66 )
Generate a list of	All references relating to this gene ( 66 )
List References by type	Research paper  ( 28 ) Supplementary material  ( 9 ) Review  ( 2 ) Personal communication to FlyBase  ( 17 ) Abstract  ( 3 ) FlyBase analysis  ( 4 ) DNA/RNA sequence record  ( 1 ) Stock list  ( 1 ) Website  ( 1 )
Recent research papers ( 7 )
	Melom and Littleton, 2013, J. Neurosci. 33(3): 1169--1178 Mutation of a NCKX Eliminates Glial Microdomain Calcium Oscillations and Enhances Seizure Susceptibility. [FBrf0220564] Menant and Karess, 2012, Cell Cycle 11(15): 2856--2863 Inducing "cytokinesis" without mitosis in unfertilized Drosophila eggs. [FBrf0219101] Baycin-Hizal et al., 2011, J. Proteome Res. 10(6): 2777--2784 GlycoFly: A Database of Drosophila N-linked Glycoproteins Identified Using SPEG-MS Techniques. [FBrf0213834] Belacortu et al., 2011, Gene Expr. Patterns 11(3-4): 190--201 Expression of Drosophila Cabut during early embryogenesis, dorsal closure and nervous system development. [FBrf0213309] Castillo et al., 2011, BMC Evol. Biol. 11: 258 Molecular evolution under increasing transposable element burden in Drosophila: A speed limit on the evolutionary arms race. [FBrf0216257] Seong et al., 2011, Biogerontology 12(2): 93--107 Genome-wide analysis of low-dose irradiated male Drosophila melanogaster with extended longevity. [FBrf0213307] Strand and Micchelli, 2011, Proc. Natl. Acad. Sci. U.S.A. 108(43): 17696--17701 Quiescent gastric stem cells maintain the adult Drosophila stomach. [FBrf0216495] Show all research papers ...
Recent reviews ( 1 )
	Broadie et al., 2011, Dev. Neurobiol. 71(11): 1102--1130 Extracellular matrix and its receptors in drosophila neural development. [FBrf0216377] Show all reviews ...