DmXPD, l(2)SH2137, ERCC2
Low-frequency RNA-Seq exon junction(s) not annotated.
Gene model reviewed during 5.51
There is only one protein coding transcript and one polypeptide associated with this gene
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Xpd using the Feature Mapper tool.
Xpd protein is evenly distributed in the syncytial blastoderm embryo, and is not localized to the nucleus. At the cellular blastoderm stage, Xpd protein is mostly nuclear in somatic cells and is not found in pole cells. After the cellular blastoderm stage, Xpd protein is nuclear in both somatic and pole cells. In third instar larvae, Xpd protein is detected in the nuclei of tissues with polytene chromosomes. On the polytene chromosomes, Xpd protein is detected in interbands and are concentrated in specific zones of the puffs. Colocalization of Xpd protein with the protein detected with human anti-p62 antibody indicates that Xpd protein is part of the TFIIH RNA polymerase II transcription complex. Staining in salivary gland chromosomes increase following UV irradiation of larvae. Some cytoplasmic expression of Xpd is also detected in all developmental stages studied; in larval tissues, some cytoplasmic expression is detected in the fat body.
GBrowse - Visual display of RNA-Seq signalsView Dmel\Xpd in GBrowse 2
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
Named "Xpd" after the human ortholog.